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Aliases for MTFR2 Gene

Aliases for MTFR2 Gene

  • Mitochondrial Fission Regulator 2 2 3 5
  • Family With Sequence Similarity 54, Member A 2 3
  • DUF729 Domain-Containing Protein 1 3 4
  • FAM54A 3 4
  • DUFD1 3 4
  • DUF729 Domain Containing 1 2

External Ids for MTFR2 Gene

Previous HGNC Symbols for MTFR2 Gene

  • DUFD1
  • FAM54A

Previous GeneCards Identifiers for MTFR2 Gene

  • GC06M136552

Summaries for MTFR2 Gene

GeneCards Summary for MTFR2 Gene

MTFR2 (Mitochondrial Fission Regulator 2) is a Protein Coding gene. An important paralog of this gene is MTFR1L.

UniProtKB/Swiss-Prot for MTFR2 Gene

  • May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTFR2 Gene

Genomics for MTFR2 Gene

Genomic Location for MTFR2 Gene

Chromosome:
6
Start:
136,231,024 bp from pter
End:
136,253,615 bp from pter
Size:
22,592 bases
Orientation:
Minus strand

Genomic View for MTFR2 Gene

Genes around MTFR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTFR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTFR2 Gene

No data available for Regulatory Elements for MTFR2 Gene

Proteins for MTFR2 Gene

  • Protein details for MTFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P444-MTFR2_HUMAN
    Recommended name:
    Mitochondrial fission regulator 2
    Protein Accession:
    Q6P444
    Secondary Accessions:
    • A8K8D8
    • E1P585
    • Q5JWR7
    • Q6ZUE8
    • Q7L3U6
    • Q9BZ39

    Protein attributes for MTFR2 Gene

    Size:
    385 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86277.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAI17908.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MTFR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTFR2 Gene

Proteomics data for MTFR2 Gene at MOPED

Post-translational modifications for MTFR2 Gene

  • Ubiquitination at Lys 125, Lys 141, and Lys 166
  • Modification sites at PhosphoSitePlus

Other Protein References for MTFR2 Gene

Antibody Products

No data available for DME Specific Peptides for MTFR2 Gene

Domains & Families for MTFR2 Gene

Protein Domains for MTFR2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6P444

UniProtKB/Swiss-Prot:

MTFR2_HUMAN :
  • Belongs to the MTFR1 family.
Family:
  • Belongs to the MTFR1 family.
genes like me logo Genes that share domains with MTFR2: view

No data available for Gene Families for MTFR2 Gene

Function for MTFR2 Gene

Molecular function for MTFR2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).
genes like me logo Genes that share phenotypes with MTFR2: view

Animal Model Products

CRISPR Products

miRNA for MTFR2 Gene

miRTarBase miRNAs that target MTFR2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTFR2 Gene

Localization for MTFR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTFR2 Gene

Mitochondrion. Note=Associated with membranes. {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MTFR2 Gene

Pathways & Interactions for MTFR2 Gene

SuperPathways for MTFR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission ISS --
genes like me logo Genes that share ontologies with MTFR2: view

No data available for Pathways by source and SIGNOR curated interactions for MTFR2 Gene

Drugs & Compounds for MTFR2 Gene

No Compound Related Data Available

Transcripts for MTFR2 Gene

Unigene Clusters for MTFR2 Gene

Mitochondrial fission regulator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTFR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for MTFR2 Gene

GeneLoc Exon Structure for
MTFR2
ECgene alternative splicing isoforms for
MTFR2

Expression for MTFR2 Gene

mRNA expression in normal human tissues for MTFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTFR2 Gene

This gene is overexpressed in Testis (x7.2).

Protein differential expression in normal tissues from HIPED for MTFR2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTFR2 Gene



SOURCE GeneReport for Unigene cluster for MTFR2 Gene Hs.121536

genes like me logo Genes that share expression patterns with MTFR2: view

Protein tissue co-expression partners for MTFR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MTFR2 Gene

Orthologs for MTFR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTFR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTFR2 35
  • 81.12 (n)
  • 71.1 (a)
MTFR2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM54A 35
  • 80.18 (n)
  • 72.82 (a)
MTFR2 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtfr2 35
  • 78.33 (n)
  • 67.93 (a)
Mtfr2 16
Mtfr2 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM54A 35
  • 98.53 (n)
  • 97.92 (a)
FAM54A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911069 35
  • 75.89 (n)
  • 65.99 (a)
oppossum
(Monodelphis domestica)
Mammalia MTFR2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTFR2 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM54A 35
  • 58.2 (n)
  • 48.3 (a)
MTFR2 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mtfr2 35
  • 52.73 (n)
  • 42.11 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153910 35
  • 50 (n)
  • 42.68 (a)
zgc:153910 36
  • 35 (a)
ManyToMany
Species with no ortholog for MTFR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTFR2 Gene

ENSEMBL:
Gene Tree for MTFR2 (if available)
TreeFam:
Gene Tree for MTFR2 (if available)

Paralogs for MTFR2 Gene

Paralogs for MTFR2 Gene

Pseudogenes.org Pseudogenes for MTFR2 Gene

genes like me logo Genes that share paralogs with MTFR2: view

Variants for MTFR2 Gene

Sequence variations from dbSNP and Humsavar for MTFR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs14215 -- 136,233,332(+) TTGAA(A/C/G)TTTCT reference, missense
rs515262 -- 136,230,805(+) CCTCA(A/G)CTCCC downstream-variant-500B
rs558284 -- 136,232,640(+) GACTT(G/T)AGATG intron-variant
rs797552 -- 136,248,499(+) tgtaa(A/G)atgtg intron-variant
rs797553 -- 136,250,327(+) CCCAG(A/G)ACGAA upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for MTFR2 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTFR2 Gene

HapMap Linkage Disequilibrium report
MTFR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTFR2 Gene

Disorders for MTFR2 Gene

Relevant External Links for MTFR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTFR2

No disorders were found for MTFR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTFR2 Gene

Publications for MTFR2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for MTFR2 Gene

Sources for MTFR2 Gene

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