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Aliases for MTFR2 Gene

Aliases for MTFR2 Gene

  • Mitochondrial Fission Regulator 2 2 3
  • Family With Sequence Similarity 54, Member A 2 3
  • DUF729 Domain-Containing Protein 1 3 4
  • DUF729 Domain Containing 1 2 3
  • FAM54A 3 4
  • DUFD1 3 4
  • Protein FAM54A 3

External Ids for MTFR2 Gene

Previous HGNC Symbols for MTFR2 Gene

  • DUFD1
  • FAM54A

Previous GeneCards Identifiers for MTFR2 Gene

  • GC06M136552

Summaries for MTFR2 Gene

GeneCards Summary for MTFR2 Gene

MTFR2 (Mitochondrial Fission Regulator 2) is a Protein Coding gene. An important paralog of this gene is MTFR1L.

UniProtKB/Swiss-Prot for MTFR2 Gene

  • May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTFR2 Gene

Genomics for MTFR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTFR2 Gene

Start:
136,231,024 bp from pter
End:
136,250,335 bp from pter
Size:
19,312 bases
Orientation:
Minus strand

Genomic View for MTFR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTFR2 Gene

No data available for Regulatory Elements for MTFR2 Gene

Proteins for MTFR2 Gene

  • Protein details for MTFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P444-MTFR2_HUMAN
    Recommended name:
    Mitochondrial fission regulator 2
    Protein Accession:
    Q6P444
    Secondary Accessions:
    • A8K8D8
    • E1P585
    • Q5JWR7
    • Q6ZUE8
    • Q7L3U6
    • Q9BZ39

    Protein attributes for MTFR2 Gene

    Size:
    385 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86277.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAI17908.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MTFR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTFR2 Gene

Proteomics data for MTFR2 Gene at MOPED

Post-translational modifications for MTFR2 Gene

  • Ubiquitination at Lys125, Lys141, and Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for MTFR2 Gene

No data available for DME Specific Peptides for MTFR2 Gene

Domains for MTFR2 Gene

Protein Domains for MTFR2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6P444

UniProtKB/Swiss-Prot:

MTFR2_HUMAN :
  • Q6P444
Family:
  • Belongs to the MTFR1 family.
genes like me logo Genes that share domains with MTFR2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MTFR2 Gene

Function for MTFR2 Gene

Molecular function for MTFR2 Gene

UniProtKB/Swiss-Prot Function: May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).

Gene Ontology (GO) - Molecular Function for MTFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MTFR2: view

Phenotypes for MTFR2 Gene

genes like me logo Genes that share phenotypes with MTFR2: view

Animal Model Products

CRISPR Products

miRNA for MTFR2 Gene

miRTarBase miRNAs that target MTFR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTFR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTFR2 Gene

Localization for MTFR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTFR2 Gene

Mitochondrion. Note=Associated with membranes. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MTFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with MTFR2: view

No data available for Subcellular locations from COMPARTMENTS for MTFR2 Gene

Pathways for MTFR2 Gene

SuperPathways for MTFR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission ISS --
GO:0007005 mitochondrion organization ISS --
GO:0009060 aerobic respiration ISS --
genes like me logo Genes that share ontologies with MTFR2: view

No data available for Pathways by source for MTFR2 Gene

Transcripts for MTFR2 Gene

Unigene Clusters for MTFR2 Gene

Mitochondrial fission regulator 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTFR2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MTFR2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTFR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for MTFR2 Gene

GeneLoc Exon Structure for
MTFR2
ECgene alternative splicing isoforms for
MTFR2

Expression for MTFR2 Gene

mRNA expression in normal human tissues for MTFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTFR2 Gene

This gene is overexpressed in Testis (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTFR2 Gene

SOURCE GeneReport for Unigene cluster for MTFR2 Gene Hs.121536

genes like me logo Genes that share expressions with MTFR2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MTFR2 Gene

Orthologs for MTFR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTFR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM54A 35
  • 98.53 (n)
  • 97.92 (a)
FAM54A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTFR2 35
  • 81.12 (n)
  • 71.1 (a)
MTFR2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM54A 35
  • 80.18 (n)
  • 72.82 (a)
MTFR2 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtfr2 35
  • 78.33 (n)
  • 67.93 (a)
Mtfr2 16
Mtfr2 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTFR2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTFR2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911069 35
  • 75.89 (n)
  • 65.99 (a)
chicken
(Gallus gallus)
Aves FAM54A 35
  • 58.2 (n)
  • 48.3 (a)
MTFR2 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mtfr2 35
  • 52.73 (n)
  • 42.11 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:153910 35
  • 50 (n)
  • 42.68 (a)
zgc:153910 36
  • 35 (a)
ManyToMany
Species with no ortholog for MTFR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTFR2 Gene

ENSEMBL:
Gene Tree for MTFR2 (if available)
TreeFam:
Gene Tree for MTFR2 (if available)

Paralogs for MTFR2 Gene

Paralogs for MTFR2 Gene

Pseudogenes.org Pseudogenes for MTFR2 Gene

genes like me logo Genes that share paralogs with MTFR2: view

Variants for MTFR2 Gene

Sequence variations from dbSNP and Humsavar for MTFR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14215 -- 136,233,332(+) TTGAA(A/G)TTTCT reference, missense
rs515262 -- 136,230,804(+) ACCTC(A/C/G)ACTCC downstream-variant-500B
rs558284 -- 136,232,640(+) GACTT(G/T)AGATG intron-variant
rs797552 -- 136,248,499(+) tgtaa(A/G)atgtg intron-variant, upstream-variant-2KB
rs797553 -- 136,250,327(+) CCCAG(A/G)ACGAA upstream-variant-2KB

Relevant External Links for MTFR2 Gene

HapMap Linkage Disequilibrium report
MTFR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTFR2 Gene

Disorders for MTFR2 Gene

No disorders were found for MTFR2 Gene.

No data available for UniProtKB/Swiss-Prot for MTFR2 Gene

Publications for MTFR2 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for MTFR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MTFR2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MTFR2
    • Block miRNA regulation of MTFR2 using miScript Target Protectors

    Sources for MTFR2 Gene

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