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MTFR1 Gene

protein-coding   GIFtS: 50
GCID: GC08P066556

Mitochondrial Fission Regulator 1

  Search for MTFR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Fission Regulator 11 2
Chondrocyte Protein With A Poly-Proline Region2 3
CHPPR2 3
FAM54A22 3
Likely Ortholog Of Chicken Chondrocyte Protein With A Poly Proline Region1
KIAA00093

External Ids:    HGNC: 295101   Entrez Gene: 96502   Ensembl: ENSG000000668557   UniProtKB: Q153903   

Export aliases for MTFR1 gene to outside databases

Previous GC identifers: GC08P066720 GC08P062046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTFR1 Gene:
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog
of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A
related pseudogene of this gene is found on chromosome X. (provided by RefSeq, Mar 2009)

GeneCards Summary for MTFR1 Gene:
MTFR1 (mitochondrial fission regulator 1) is a protein-coding gene. An important paralog of this gene is MTFR2.

UniProtKB/Swiss-Prot: MTFR1_HUMAN, Q15390
Function: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and
fission (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTFR1 gene promoter:
         Spz1   Pax-5   GATA-1   Evi-1   Meis-1b   FOXO1a   c-Myb   Meis-1a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTFR1 promoter sequence
   Search Chromatin IP Primers for MTFR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTFR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

MTFR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTFR1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P066556:  view genomic region     (about GC identifiers)

Start:
66,556,888 bp from pter      End:
66,683,496 bp from pter
Size:
126,609 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTFR1_HUMAN, Q15390 (See protein sequence)
Recommended Name: Mitochondrial fission regulator 1 precursor  
Size: 333 amino acids; 37000 Da
Sequence caution: Sequence=BAA02798.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: E7EP84 Q6IB94 Q7Z669 Q86XH5 Q8IVD7
Alternative splicing: 2 isoforms:  Q15390-1   Q15390-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTFR1: NX_Q15390

Explore proteomics data for MTFR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTFR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139310.1  NP_001139311.1  NP_055452.3  

    ENSEMBL proteins: 
     ENSP00000429450   ENSP00000262146   ENSP00000430621   ENSP00000429253   ENSP00000436928  
     ENSP00000391502  

    MTFR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MTFR1

     
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    LSBio Antibodies in human, mouse, rat for MTFR1

    MTFR1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007972 Mtfr1

    Graphical View of Domain Structure for InterPro Entry Q15390

    ProtoNet protein and cluster: Q15390

    UniProtKB/Swiss-Prot: MTFR1_HUMAN, Q15390
    Similarity: Belongs to the MTFR1 family


    Find genes that share domains with MTFR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTFR1_HUMAN, Q15390
    Function: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and
    fission (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for MTFR1:

     Decreased influenza A virus in 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Mtfr1):
     cellular 

    Find genes that share phenotypes with MTFR1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTFR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTFR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTFR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTFR1

    miRNA
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    miRTarBase miRNAs that target MTFR1:
    hsa-let-7e-5p (MIRT051560), hsa-mir-1227-3p (MIRT036394), hsa-mir-455-3p (MIRT037827)

    Block miRNA regulation of human, mouse, rat MTFR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTFR1 (see all 14):
    hsa-miR-4291 hsa-miR-31 hsa-miR-577 hsa-miR-448 hsa-miR-520f hsa-miR-429 hsa-miR-125a-3p hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmidMTFR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MTFR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTFR1_HUMAN, Q15390: Mitochondrion (By similarity). Note=May be associated with the inner and the outer
    mitochondrial membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion ISS--
    GO:0005886plasma membrane IDA10942595

    Find genes that share ontologies with MTFR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTFR1
    Interactions:

        Search GeneGlobe Interaction Network for MTFR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for MTFR1 (Q153902, 3 ENSP000002621464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUSP23Q9BVJ72, 3, ENSP000003570874MINT-8254710 I2D: score=2 STRING: ENSP00000357087
    PIN1Q135262, 3, ENSP000002479704MINT-64243 I2D: score=4 STRING: ENSP00000247970
    DDIT3P356383I2D: score=1 
    UVRAGQ9P2Y53I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000266mitochondrial fission ISS--
    GO:0007005mitochondrion organization ISS--
    GO:0009060aerobic respiration ISS--

    Find genes that share ontologies with MTFR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTFR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTFR1 gene (3 alternative transcripts): 
    NM_001145838.1  NM_001145839.1  NM_014637.3  

    Unigene Cluster for MTFR1:

    Mitochondrial fission regulator 1
    Hs.584788  [show with all ESTs]
    Unigene Representative Sequence: NM_014637
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523170 ENST00000523222 ENST00000522239 ENST00000424808(uc011lep.2)
    ENST00000262146(uc003xvm.2) ENST00000517944 ENST00000518800 ENST00000518636
    ENST00000521247 ENST00000527155 ENST00000518352 ENST00000523158 ENST00000520398
    ENST00000527553 ENST00000458689(uc003xvn.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTFR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTFR1 (see all 14):
    hsa-miR-4291 hsa-miR-31 hsa-miR-577 hsa-miR-448 hsa-miR-520f hsa-miR-429 hsa-miR-125a-3p hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmidMTFR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MTFR1
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    OriGene ORF clones in mouse, rat for MTFR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MTFR1 (NM_001145839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTFR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFR1
    Primer
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    OriGene qPCR primer pairs and template standards for MTFR1
    OriGene qSTAR qPCR primer pairs in human, mouse for MTFR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTFR1
      QuantiTect SYBR Green Assays in human, mouse, rat MTFR1
      QuantiFast Probe-based Assays in human, mouse, rat MTFR1

    Additional mRNA sequence: 

    AK024332.1 AK298945.1 AK304716.1 AK316202.1 BC036116.1 BC043498.2 BX537854.1 BX647507.1 
    CR456910.1 D13634.1 

    17 DOTS entries:

    DT.116228  DT.100818760  DT.92432665  DT.100722886  DT.92432659  DT.100818756  DT.452192  DT.102842971 
    DT.121473989  DT.75166608  DT.91822189  DT.100715111  DT.121474068  DT.40122152  DT.95148449  DT.95276427 
    DT.95276430 

    Selected AceView cDNA sequences (see all 216):

    BM894012 BX427552 BM719185 CR621667 BM894278 CA426649 AI568459 BU195839 
    BX113306 BC043498 BM557425 BQ224024 AA226795 AA761502 CD243122 BM466435 
    AW194480 AL548443 BM683140 BC036116 AA548186 BQ432449 BI829952 BP343528 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTFR1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:              -                 -                                                   
    SP2:        -     -                 -                                                   
    SP3:                                                                                    
    SP4:                                -     -                                             
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for MTFR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTFR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACCTCTC
    MTFR1 Expression
    About this image


    MTFR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    MTFR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTFR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584788
        Custom PCR Arrays for MTFR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MTFR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtfr11 , 5 mitochondrial fission regulator 11, 5 82.72(n)1
    77.13(a)1
      3 (5.36 cM)5
    674721  NM_001253391.11  NP_001240320.11 
     191873275 
    chicken
    (Gallus gallus)
    Aves MTFR11 mitochondrial fission regulator 1 69.81(n)
    65.99(a)
      395222  NM_204543.1  NP_989874.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTFR16
    mitochondrial fission regulator 1
    50(a)
    1 ↔ 1
    4(30539355-30556954)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mtfr11 mitochondrial fission regulator 1 63.94(n)
    62.58(a)
      100498377  XM_002940557.2  XP_002940603.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtfr11 mitochondrial fission regulator 1 56.29(n)
    51.9(a)
      494035  NM_001008578.1  NP_001008578.1 


    ENSEMBL Gene Tree for MTFR1 (if available)
    TreeFam Gene Tree for MTFR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTFR1 gene
    MTFR22  MTFR1L2  
    1 SIMAP similar gene for MTFR1 using alignment to 6 protein entries:     MTFR1_HUMAN (see all proteins):
    MTFR1L

    Find genes that share paralogs with MTFR1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MTFR1
    PGOHUM00000241365


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTFR1 (see all 1254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498602811,2
    --66554966(+) CATTTC/TGGCCT 2 -- us2k10--------
    rs58920341,2
    C--66555016(+) AGCCC-/TTTTTT 2 -- us2k1 trp30--------
    rs1475298791,2
    --66555132(+) CTGAGC/TAGCTG 2 -- us2k10--------
    rs100897081,2
    C,F,H--66555162(+) ccacaC/Ttcagc 2 -- us2k114Minor allele frequency- T:0.30NA WA CSA EA 378
    rs1161426021,2
    F--66555345(+) GGGCCA/GGGTGC 2 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1919298071,2
    --66555389(+) GAGTTC/GGCAGA 2 -- us2k10--------
    rs1824423371,2
    --66555428(+) CCAGGA/GAAGAC 2 -- us2k10--------
    rs668516661,2
    C--66555442(+) AGTAAC/GTTATC 2 -- us2k14Minor allele frequency- G:0.08WA NA EA 360
    rs69917311,2
    C,F,A,H--66555467(+) GTTCAG/ATTcaa 2 -- us2k116Minor allele frequency- A:0.33NS EA NA WA CSA 795
    rs1871394611,2
    --66555627(+) AGACAC/TTTTCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTFR1 (66556888 - 66683496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MTFR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676136CNV Deletion23128226
    esv1024224CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTFR1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTFR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    Find genes that share disorders with MTFR1           About GenesLikeMe

    Genetic Association Database (GAD): MTFR1
    Human Genome Epidemiology (HuGE) Navigator: MTFR1 (2 documents)

    Export disorders for MTFR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTFR1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with MTFR1)
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    1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission. (PubMed id 15389597)1, 3 Tonachini L....Castagnola P. (J. Cell. Physiol. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PubMed id 7584028)1, 3 Nomura N....Tabata S. (DNA Res. 1994)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of Mtfr1/Chppr-deficient mice. (PubMed id 17709566)1 Monticone M....Castagnola P. (Reproduction 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9650 HGNC: 29510 AceView: CHPPR Ensembl:ENSG00000066855 euGenes: HUgn9650
    ECgene: MTFR1 H-InvDB: MTFR1

    (According to HUGE)
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    HUGE: KIAA0009

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTFR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTFR1 gene:
    Search GeneIP for patents involving MTFR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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