MTFP1 Gene
protein-coding GIFtS: 41
GCID: GC22P030822
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mitochondrial fission process 1
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Aliases
for MTFP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Fission Process 11 2 | | Mitochondrial Fission Process Protein 12 | | MTP181 2 3 | | Mitochondrial Fission Protein MTP182 | | Mitochondrial 18 KDa Protein2 3 | | Mitochondrial Protein 18 KDa2 | | HSPC2421 | | |
Export aliases for MTFP1 gene to outside databasesPrevious GC identifer: GC22P013782 |
Summaries
for MTFP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MTFP1:
MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834)signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 (PubMed15155745)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: MTFP1_HUMAN, Q9UDX5Function: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces therelease of cytochrome c, which activates the caspase cascade and leads to apoptosis
Gene Wiki entry for MTFP1 (MTP18)
|
Genomic Views
for MTFP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MTFP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTFP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTFP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22qMTFP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P030822: view genomic region
(about GC identifiers)
Start:
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30,821,518 bp from pter |
End:
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30,825,045 bp from pter |
Size:
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3,528 bases |
Orientation:
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plus strand |
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Proteins
for MTFP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTFP1_HUMAN, Q9UDX5 (See
protein sequence)Recommended Name: Mitochondrial fission process protein 1 Size: 166 amino acids; 18010 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (Probable)
Sequence caution: Sequence=AAF36162.1; Type=Frameshift; Positions=Several; Sequence=AAG43136.1; Type=Frameshift;Positions=66, 84;
Secondary accessions: A6NFQ5 Q9H3K1 Q9P0N6Alternative splicing: 2 isoforms: Q9UDX5-1 Q9UDX5-2 Explore the universe of human proteins at neXtProt for MTFP1: NX_Q9UDX5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UDX5
MTFP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001003704.1 NP_057582.2
ENSEMBL proteins: ENSP00000266263 ENSP00000347267 ENSP00000393954 ENSP00000383926
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MTFP1 for ontologies About GeneDecksing
MTFP1 Antibody Products:
Assay Products for MTFP1: |
Protein
Domains /
Families
for MTFP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTFP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UDX5ProtoNet protein and cluster: Q9UDX5 UniProtKB/Swiss-Prot: MTFP1_HUMAN, Q9UDX5Similarity: Belongs to the MTFP1 family |
Function
for MTFP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MTFP1_HUMAN, Q9UDX5Function: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces therelease of cytochrome c, which activates the caspase cascade and leads to apoptosisInduction: Expression is regulated by the phosphatidylinositol (PI) 3-kinase pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTFP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTFP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MTFP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFP1 |
|
Pathways & Interactions
for MTFP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTFP1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for MTFP1 (Q9UDX53 ENSP000002662634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MTFP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTFP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTFP1
Search CenterWatch for drugs/clinical trials and news about MTFP1
|
Transcripts
for MTFP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTFP1 gene (2 alternative transcripts): NM_001003704.2 NM_016498.4 Unigene Cluster for MTFP1: Mitochondrial fission process 1 Hs.713636 [show with all ESTs]Unigene Representative Sequence: BF2145035 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000266263(uc003ahw.2 uc003ahx.2) ENST00000489658 ENST00000355143
ENST00000412752 ENST00000407550
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTFP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTFP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MTFP1 (NM_016498) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTFP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFP1 |
Additional cDNA sequence: AF060924.1 AF151076.1 AK026104.1 BC001608.1 BC009300.2 BC014446.1 BC030989.2 BC038831.2 BC046132.1 CR456345.1 11 DOTS entries: DT.453561 DT.91719797 DT.91890574 DT.315633 DT.120634089 DT.95173146 DT.100726535 DT.95173148 DT.95173149 DT.95280054 DT.120633972 24/195 AceView cDNA sequences (see all 195): AI640394 CR607289 AA953952 CR600583 CF528143 BQ889535 BC014446 AI220261 AA761033 AA613122 BQ187590 AI206006 AW296500 BQ184491 BM855670 BC009300 CB135302 AA775898 AI142521 BE312413 BI225399 BM808365 BU145885 BQ642342
GeneLoc Exon Structure
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Expression
for MTFP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTFP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGTATGGC
About this image
See MTFP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTFP1
SOURCE GeneReport for Unigene cluster: Hs.713636
SABiosciences Custom PCR Arrays for MTFP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTFP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTFP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTFP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTFP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFP1 |
Orthologs
for MTFP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MTFP1 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for MTFP1 (if available)
TreeFam Gene Tree for MTFP1 (if available) |
Paralogs
for MTFP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MTFP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTFP1 (30821518 - 30825045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTFP1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MTFP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTFP1 for disorders About GeneDecksing
OMIM gene information: 610235
OMIM disorders: --
4  diseases for MTFP1: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma atherosclerosis cholesterol
Export disorders for MTFP1 gene to outside databases
|
Publications
for MTFP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTFP1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MTFP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. (PubMed id 15155745)1, 2, 3, 9 Tondera D....Kaufmann J. (2004)
- The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells. (PubMed id 15985469)1, 2, 3 Tondera D....Santel A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for MTFP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTFP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTFP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTFP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MTFP1 gene:
Search GeneIP for patents involving MTFP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTFP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTFP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTFP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTFP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTFP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTFP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTFP1 |
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 | | | MTFP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for MTFP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFP1 |
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