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Aliases for MTFP1 Gene

Aliases for MTFP1 Gene

  • Mitochondrial Fission Process 1 2 3 5
  • Mitochondrial 18 KDa Protein 3 4
  • MTP18 3 4
  • Mitochondrial Fission Protein MTP18 3
  • Mitochondrial Protein 18 KDa 3
  • HSPC242 3

External Ids for MTFP1 Gene

Previous GeneCards Identifiers for MTFP1 Gene

  • GC22P013782
  • GC22P030822

Summaries for MTFP1 Gene

Entrez Gene Summary for MTFP1 Gene

  • MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MTFP1 Gene

MTFP1 (Mitochondrial Fission Process 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTFP1 Gene

  • Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.

Gene Wiki entry for MTFP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTFP1 Gene

Genomics for MTFP1 Gene

Genomic Location for MTFP1 Gene

30,425,530 bp from pter
30,429,054 bp from pter
3,525 bases
Plus strand

Genomic View for MTFP1 Gene

Genes around MTFP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTFP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTFP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTFP1 Gene

No data available for Regulatory Elements for MTFP1 Gene

Proteins for MTFP1 Gene

  • Protein details for MTFP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial fission process protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NFQ5
    • Q9H3K1
    • Q9P0N6

    Protein attributes for MTFP1 Gene

    166 amino acids
    Molecular mass:
    18010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF36162.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAG43136.1; Type=Frameshift; Positions=66, 84; Evidence={ECO:0000305};

    Alternative splice isoforms for MTFP1 Gene


neXtProt entry for MTFP1 Gene

Proteomics data for MTFP1 Gene at MOPED

Post-translational modifications for MTFP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTFP1 Gene

No data available for DME Specific Peptides for MTFP1 Gene

Domains & Families for MTFP1 Gene

Protein Domains for MTFP1 Gene

Suggested Antigen Peptide Sequences for MTFP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MTFP1 family.
  • Belongs to the MTFP1 family.
genes like me logo Genes that share domains with MTFP1: view

No data available for Gene Families for MTFP1 Gene

Function for MTFP1 Gene

Molecular function for MTFP1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.
UniProtKB/Swiss-Prot Induction:
Expression is regulated by the phosphatidylinositol (PI) 3-kinase pathway.

Phenotypes for MTFP1 Gene

genes like me logo Genes that share phenotypes with MTFP1: view

Animal Model Products

CRISPR Products

miRNA for MTFP1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTFP1 Gene

Localization for MTFP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTFP1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MTFP1 Gene COMPARTMENTS Subcellular localization image for MTFP1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MTFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IDA 15985469
genes like me logo Genes that share ontologies with MTFP1: view

Pathways & Interactions for MTFP1 Gene

SuperPathways for MTFP1 Gene

No Data Available

Interacting Proteins for MTFP1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000266263 Q9UDX5-MTFP1_HUMAN for MTFP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MTFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with MTFP1: view

No data available for Pathways by source and SIGNOR curated interactions for MTFP1 Gene

Drugs & Compounds for MTFP1 Gene

No Compound Related Data Available

Transcripts for MTFP1 Gene

Unigene Clusters for MTFP1 Gene

Mitochondrial fission process 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTFP1 Gene

No ASD Table

Relevant External Links for MTFP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTFP1 Gene

mRNA expression in normal human tissues for MTFP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTFP1 Gene

This gene is overexpressed in Retina (16.6), Breast (9.0), and Tlymphocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTFP1 Gene

SOURCE GeneReport for Unigene cluster for MTFP1 Gene Hs.713636

genes like me logo Genes that share expression patterns with MTFP1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MTFP1 Gene

Orthologs for MTFP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTFP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTFP1 35
  • 98.8 (n)
  • 100 (a)
MTFP1 36
  • 100 (a)
(Bos Taurus)
Mammalia MTP18 36
  • 91 (a)
MTFP1 35
  • 87.95 (n)
  • 90.96 (a)
(Canis familiaris)
Mammalia MTFP1 35
  • 86.75 (n)
  • 92.77 (a)
MTFP1 36
  • 68 (a)
(Mus musculus)
Mammalia Mtfp1 16
Mtfp1 36
  • 87 (a)
Mtfp1 35
  • 86.87 (n)
  • 87.27 (a)
(Monodelphis domestica)
Mammalia MTFP1 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Mtfp1 35
  • 86.87 (n)
  • 87.27 (a)
(Gallus gallus)
Aves MTFP1 35
  • 73.08 (n)
  • 72.44 (a)
(Anolis carolinensis)
Reptilia MTFP1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtfp1 35
  • 67.3 (n)
  • 72.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4958 35
(Danio rerio)
Actinopterygii MTFP1 36
  • 53 (a)
mtfp1 35
  • 73.97 (n)
  • 74.66 (a)
zgc63910 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001603 35
  • 55.63 (n)
  • 55.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7772 36
  • 43 (a)
CG7772 35
  • 57.31 (n)
  • 51.08 (a)
(Caenorhabditis elegans)
Secernentea mtp-18 35
  • 51.36 (n)
  • 51.57 (a)
mtp-18 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for MTFP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTFP1 Gene

Gene Tree for MTFP1 (if available)
Gene Tree for MTFP1 (if available)

Paralogs for MTFP1 Gene

No data available for Paralogs for MTFP1 Gene

Variants for MTFP1 Gene

Sequence variations from dbSNP and Humsavar for MTFP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2072159 -- 30,427,078(+) CCACT(A/G)GCCAC intron-variant
rs5753130 -- 30,427,209(+) GTGAC(C/T)GTGGC intron-variant, reference, synonymous-codon
rs11558623 -- 30,428,863(+) AGGAA(C/T)AGGCC utr-variant-3-prime
rs16988620 -- 30,429,545(+) AGGGA(A/G)TGGCC downstream-variant-500B
rs34217722 -- 30,427,713(+) GTGCA(-/C)CCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTFP1 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv914970 CNV Loss 21882294

Variation tolerance for MTFP1 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTFP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTFP1 Gene

Disorders for MTFP1 Gene

Relevant External Links for MTFP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MTFP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTFP1 Gene

Publications for MTFP1 Gene

  1. Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. (PMID: 15155745) Tondera D. … Kaufmann J. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells. (PMID: 15985469) Tondera D. … Santel A. (J. Cell Sci. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genetic variants associated with breast size also influence breast cancer risk. (PMID: 22747683) Eriksson N. … Tung J.Y. (BMC Med. Genet. 2012) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for MTFP1 Gene

Sources for MTFP1 Gene

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