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Aliases for MTFP1 Gene

Aliases for MTFP1 Gene

  • Mitochondrial Fission Process 1 2 3
  • Mitochondrial 18 KDa Protein 3 4
  • MTP18 3 4
  • Mitochondrial Fission Process Protein 1 3
  • Mitochondrial Fission Protein MTP18 3
  • Mitochondrial Protein 18 KDa 3
  • HSPC242 3

External Ids for MTFP1 Gene

Summaries for MTFP1 Gene

Entrez Gene Summary for MTFP1 Gene

  • MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MTFP1 Gene

MTFP1 (Mitochondrial Fission Process 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTFP1 Gene

  • Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.

Gene Wiki entry for MTFP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTFP1 Gene

Genomics for MTFP1 Gene

Genomic Location for MTFP1 Gene

30,425,530 bp from pter
30,429,054 bp from pter
3,525 bases
Plus strand

Genomic View for MTFP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTFP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTFP1 Gene

No data available for Regulatory Elements for MTFP1 Gene

Proteins for MTFP1 Gene

  • Protein details for MTFP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial fission process protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NFQ5
    • Q9H3K1
    • Q9P0N6

    Protein attributes for MTFP1 Gene

    166 amino acids
    Molecular mass:
    18010 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF36162.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAG43136.1; Type=Frameshift; Positions=66, 84; Evidence={ECO:0000305};

    Alternative splice isoforms for MTFP1 Gene


neXtProt entry for MTFP1 Gene

Proteomics data for MTFP1 Gene at MOPED

Post-translational modifications for MTFP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTFP1 Gene

No data available for DME Specific Peptides for MTFP1 Gene

Domains for MTFP1 Gene

Protein Domains for MTFP1 Gene

Suggested Antigen Peptide Sequences for MTFP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MTFP1 family.:
    • Q9UDX5
genes like me logo Genes that share domains with MTFP1: view

No data available for Gene Families for MTFP1 Gene

Function for MTFP1 Gene

Molecular function for MTFP1 Gene

UniProtKB/Swiss-Prot Function: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis.
UniProtKB/Swiss-Prot Induction: Expression is regulated by the phosphatidylinositol (PI) 3-kinase pathway.

miRNA for MTFP1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTFP1 Gene

Localization for MTFP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTFP1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MTFP1 Gene COMPARTMENTS Subcellular localization image for MTFP1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MTFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IDA 15985469
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MTFP1: view

Pathways for MTFP1 Gene

SuperPathways for MTFP1 Gene

No Data Available

Interacting Proteins for MTFP1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000266263 Q9UDX5-MTFP1_HUMAN for MTFP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MTFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IMP 15985469
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with MTFP1: view

No data available for Pathways by source for MTFP1 Gene

Transcripts for MTFP1 Gene

Unigene Clusters for MTFP1 Gene

Mitochondrial fission process 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTFP1 Gene

No ASD Table

Relevant External Links for MTFP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTFP1 Gene

mRNA expression in normal human tissues for MTFP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTFP1 Gene

SOURCE GeneReport for Unigene cluster for MTFP1 Gene Hs.713636

genes like me logo Genes that share expressions with MTFP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTFP1 Gene

Orthologs for MTFP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTFP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTFP1 35
  • 98.8 (n)
  • 100 (a)
MTFP1 36
  • 100 (a)
(Bos Taurus)
Mammalia MTFP1 35
  • 87.95 (n)
  • 90.96 (a)
MTP18 36
  • 91 (a)
(Canis familiaris)
Mammalia MTFP1 35
  • 86.75 (n)
  • 92.77 (a)
MTFP1 36
  • 68 (a)
(Mus musculus)
Mammalia Mtfp1 35
  • 86.87 (n)
  • 87.27 (a)
Mtfp1 16
Mtfp1 36
  • 87 (a)
(Monodelphis domestica)
Mammalia MTFP1 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Mtfp1 35
  • 86.87 (n)
  • 87.27 (a)
(Gallus gallus)
Aves MTFP1 35
  • 73.08 (n)
  • 72.44 (a)
(Anolis carolinensis)
Reptilia MTFP1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mtfp1 35
  • 67.3 (n)
  • 72.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4958 35
(Danio rerio)
Actinopterygii mtfp1 35
  • 73.97 (n)
  • 74.66 (a)
MTFP1 36
  • 53 (a)
zgc63910 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001603 35
  • 55.63 (n)
  • 55.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7772 35
  • 57.31 (n)
  • 51.08 (a)
CG7772 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea mtp-18 35
  • 51.36 (n)
  • 51.57 (a)
mtp-18 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for MTFP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTFP1 Gene

Gene Tree for MTFP1 (if available)
Gene Tree for MTFP1 (if available)

Paralogs for MTFP1 Gene

No data available for Paralogs for MTFP1 Gene

Variants for MTFP1 Gene

Sequence variations from dbSNP and Humsavar for MTFP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1046176 -- 30,428,499(+) GCAAG(C/T)TCTAC reference, missense
rs1062997 -- 30,428,710(+) GGGAG(A/T)CACAG utr-variant-3-prime
rs2072158 -- 30,426,473(+) AAGAC(C/G)AGGAA intron-variant
rs2072159 -- 30,427,078(+) CCACT(A/G)GCCAC intron-variant
rs2072160 -- 30,427,126(+) GGATT(G/T)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTFP1 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv914970 CNV Loss 21882294

Relevant External Links for MTFP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTFP1 Gene

Disorders for MTFP1 Gene

No disorders were found for MTFP1 Gene.

No data available for UniProtKB/Swiss-Prot for MTFP1 Gene

Publications for MTFP1 Gene

  1. Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. (PMID: 15155745) Tondera D. … Kaufmann J. (J. Biol. Chem. 2004) 2 3 4 23
  2. The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells. (PMID: 15985469) Tondera D. … Santel A. (J. Cell Sci. 2005) 2 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for MTFP1 Gene

Sources for MTFP1 Gene

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