MTFMT Gene
protein-coding GIFtS: 56
GCID: GC15M065293
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|
mitochondrial methionyl-tRNA formyltransferase
| |
Aliases for MTFMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mitochondrial Methionyl-TRNA Formyltransferase1 2 | | EC 2.1.2.93 | | FMT11 2 3 | | FMT3 | | COXPD152 | | MtFMT3 | | Methionyl-TRNA Formyltransferase, Mitochondrial2 | | |
Export aliases for MTFMT gene to outside databasesPrevious GC identifers: GC15M063082 GC15M042118 |
Summaries for MTFMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MTFMT: The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation ofmethionyl-tRNA. (provided by RefSeq, Jun 2011) UniProtKB/Swiss-Prot: FMT_HUMAN, Q96DP5Function: Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and anelongator species via an unknown mechanism (By similarity) Gene Wiki entry for MTFMT
|
Genomic Views for MTFMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MTFMT gene promoter: MIF-1 Nkx2-5 IRF-1 Cdc5 Evi-1 GATA-1 PPAR-alpha PPAR-gamma1 Sox9 PPAR-gamma2 Other transcription factors
Search SABiosciences Chromatin IP Primers for MTFMT
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTFMT |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.31MTFMT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M065293: view genomic region
(about GC identifiers)
Start:
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65,293,850 bp from pter |
End:
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65,321,977 bp from pter |
Size:
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28,128 bases |
Orientation:
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minus strand |
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Proteins for MTFMT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FMT_HUMAN, Q96DP5 (See
protein sequence)Recommended Name: Methionyl-tRNA formyltransferase, mitochondrial precursor Size: 389 amino acids; 43832 Da
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAH16630.2; Type=Erroneous initiation; Sequence=AAH33687.1; Type=Erroneous initiation;Sequence=BAB70984.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for MTFMT: NX_Q96DP5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96DP5 MTFMT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_640335.2 ENSEMBL proteins: ENSP00000220058 ENSP00000452646 ENSP00000457257 ENSP00000443754 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
MTFMT for ontologies About GeneDecksing
MTFMT Antibody Products: Assay Products for MTFMT: |
Protein
Domains / Families for MTFMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTFMT for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96DP5ProtoNet protein and cluster: Q96DP5 UniProtKB/Swiss-Prot: FMT_HUMAN, Q96DP5Domain: Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-bindingsite and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylationreactionSimilarity: Belongs to the fmt family |
Function for MTFMT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: FMT_HUMAN, Q96DP5Function: Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and anelongator species via an unknown mechanism (By similarity)Catalytic activity: 10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate +N-formylmethionyl-tRNA(fMet)Enzyme Number (IUBMB): EC 2.1.2.91
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTFMT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTFMT (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MTFMT (NM_139242) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTFMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFMT  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFMT |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004479 | methionyl-tRNA formyltransferase activity |
IEA | -- | | GO:0008168 | methyltransferase activity |
IEA | -- | | GO:0016742 | hydroxymethyl-, formyl- and related transferase activity |
-- | -- |
MTFMT for ontologies About GeneDecksing
Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mtfmt):
MTFMT for phenotypes About GeneDecksing
|
Pathways & Interactions for MTFMT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Methionine metabolism | | | 2 | One Carbon Metabolism | | | 3 | tRNA Aminoacylation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 EMD Millipore Pathway for MTFMT
1 GeneGo (Thomson Reuters) Pathway for MTFMT 1 BioSystems Pathway for MTFMT 
2
Kegg Pathways (Kegg details for MTFMT):
MTFMT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTFMT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
 5/17 Interacting proteins for MTFMT (Q96DP53 ENSP000002200584) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009058 | biosynthetic process |
-- | -- |
MTFMT for ontologies About GeneDecksing
|
Drugs & Compounds for MTFMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MTFMT
2 HMDB Compounds for MTFMT About this table
1 DrugBank Compound for MTFMT About this table
Search CenterWatch for drugs/clinical trials and news about MTFMT / FMT 
|
Transcripts for MTFMT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MTFMT gene: NM_139242.3 Unigene Cluster for MTFMT: Mitochondrial methionyl-tRNA formyltransferase Hs.531615 [show with all ESTs]Unigene Representative Sequence: NM_1392427 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000220058(uc002aof.4) ENST00000558460 ENST00000560717 ENST00000543678 ENST00000558614 ENST00000561025 ENST00000559633
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTFMT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTFMT (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MTFMT (NM_139242) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTFMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFMT  |
Additional cDNA sequence: AK055688.1 AK301390.1 BC016630.1 BC033687.1 4 DOTS entries: DT.305132 DT.75176931 DT.100021699 DT.100747233 24/44 AceView cDNA sequences (see all 44): BM849836 CR595154 BC016630 AI216362 AL529843 AL701820 BC033687 AK055688 NM_139242 BM785042 BQ707648 BX094075 AA912159 BM126929 BM993751 BG028642 CF128305 AW139851 BQ012033 BM127530 CK903193 BQ012730 BI753421 AI292236 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MTFMT About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MTFMT
|
Expression for MTFMT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTFMT expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTCATTTCAG
About this image See MTFMT Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MTFMT
SOURCE GeneReport for Unigene cluster: Hs.531615 SABiosciences Custom PCR Arrays for MTFMT
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTFMT Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MTFMT | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTFMT | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTFMT | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFMT |
Orthologs for MTFMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MTFMT gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for MTFMT (if available) TreeFam Gene Tree for MTFMT (if available)  |
Paralogs for MTFMT gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for MTFMT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 15 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MTFMT (65293850 - 65321977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MTFMT: -- Human Gene Mutation Database (HGMD): MTFMT
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTFMT |
|
Disorders
/ Diseases for MTFMT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTFMT for disorders About GeneDecksing
OMIM gene information: 611766
OMIM disorders: --
5 diseases for MTFMT: About MalaCardsfragile x syndrome leigh disease pneumonia tuberculosis mycobacterium tuberculosis 1 disease from the University of Copenhagen DISEASES database for MTFMT:Leigh disease Human Genome Epidemiology (HuGE) Navigator: MTFMT (1 document) Export disorders for MTFMT gene to outside databases
|
Publications for MTFMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTFMT gene integrated from 9 sources: (articles sorted by number of sources associating them with MTFMT) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mammalian mitochondrial methionyl-tRNA transformylase from bovine liver. Purification, characterization, and gene structure. (PubMed id 9614118)1, 3 Takeuchi N....Watanabe K. (1998)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mutations in MTFMT underlie a human disorder of formy lation causing impaired mitochondrial translation. (PubMed id 21907147)1 Tucker E.J....Mootha V.K. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Initiation of protein synthesis in Saccharomyces cere visiae mitochondria without formylation of the initiator tRNA. (PubMed id 10781559)7 Li Y....RajBhandary U.L. (2000)
- Modular organization of FDH: Exploring the basis of hydrolase catalysis. (PubMed id 16597835)9 Reuland S.N....Krupenko S.A. (2006)
|
External Searches for MTFMT gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MTFMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTFMT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTFMT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MTFMT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTFMT gene: Search GeneIP for patents involving MTFMT
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MTFMT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for MTFMT | | OriGene Custom Protein Services for MTFMT | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTFMT | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTFMT | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTFMT | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTFMT | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTFMT | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTFMT |
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 |  |  |  | |
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 | | MTFMT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTFMT |
|  |  |  | | | Search ThermoFisher Antibodies for MTFMT |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTFMT |
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