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MTF2 Gene

protein-coding   GIFtS: 54
GCID: GC01P093544

Metal Response Element Binding Transcription Factor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metal Response Element Binding Transcription Factor 21 2     hPCl22 3
PCL22 3 5     M962 5
Polycomb-Like 21 2     TDRD19A2
Tudor Domain Containing 19A1 2     dJ976O13.22
Metal Regulatory Transcription Factor 22 3     Metal Response Element-Binding Transcription Factor 22
Metal-Response Element DNA-Binding Protein M962 3     Metal-Response Element-Binding Transcription Factor 22
Polycomb-Like Protein 22 3     Putative DNA Binding Protein2

External Ids:    HGNC: 295351   Entrez Gene: 228232   Ensembl: ENSG000001430337   OMIM: 6098825   UniProtKB: Q9Y4833   

Export aliases for MTF2 gene to outside databases

Previous GC identifers: GC01P093258 GC01P093317 GC01P091666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTF2 Gene:
MTF2 (metal response element binding transcription factor 2) is a protein-coding gene. Diseases associated with MTF2 include endometrial stromal sarcoma, and cholera. GO annotations related to this gene include methylated histone residue binding. An important paralog of this gene is PHF19.

UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483
Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and
recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the
PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks
during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the
inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES
cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions
may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by
suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of
MT1A gene promoter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTF2 gene promoter:
         GCNF   p300   HSF1 (long)   MZF-1   CREB   GCNF-1   IRF-7A   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTF2 promoter sequence
   Search Chromatin IP Primers for MTF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

MTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P093544:  view genomic region     (about GC identifiers)

Start:
93,544,792 bp from pter      End:
93,604,638 bp from pter
Size:
59,847 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483 (See protein sequence)
Recommended Name: Metal-response element-binding transcription factor 2  
Size: 593 amino acids; 67106 Da
Subunit: Associated component of the PRC2 complex (By similarity)
Secondary accessions: A6NGQ9 A8K2Q3 B1AKT5 B1AKT6 Q9UES9 Q9UP40
Alternative splicing: 4 isoforms:  Q9Y483-1   Q9Y483-2   Q9Y483-3   Q9Y483-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTF2: NX_Q9Y483

Explore proteomics data for MTF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157863.1  NP_001157864.1  NP_001157865.1  NP_031384.1  

    ENSEMBL proteins: 
     ENSP00000359321   ENSP00000359326   ENSP00000444962   ENSP00000443295  
    Reactome Protein details: Q9Y483

    MTF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MTF2
    GenScript Custom Purified and Recombinant Proteins Services for MTF2
    Novus Biologicals MTF2 Protein
    Novus Biologicals MTF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTF2

    MTF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MTF2
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MTF2
    Novus Biologicals MTF2 Antibodies
    Abcam antibodies for MTF2 (Q96G26, Q9Y483)
    Cloud-Clone Corp. Antibodies for MTF2
    Search ThermoFisher Antibodies for MTF2
    LSBio Antibodies in human, mouse, rat for MTF2

    MTF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTF2
    Cloud-Clone Corp. CLIAs for MTF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 7):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR025894 Mtf2_C_dom
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y483

    ProtoNet protein and cluster: Q9Y483

    2 Blocks protein domains:
    IPB001965 Zn-finger-like
    IPB002999 Tudor domain


    UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483
    Domain: The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662)
    Similarity: Belongs to the Polycomblike family
    Similarity: Contains 2 PHD-type zinc fingers
    Similarity: Contains 1 Tudor domain


    MTF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTF2_HUMAN, Q9Y483
    Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and
    recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the
    PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks
    during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the
    inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES
    cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions
    may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by
    suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of
    MT1A gene promoter (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA--
         
    MTF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MTF2:
     Increased HPV18 LCR reporter a 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mtf2):
     cellular  craniofacial  embryogenesis  growth/size/body  limbs/digits/tail 
     mortality/aging  nervous system  reproductive system  skeleton 

    MTF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mtf2tm1.1Hko for MTF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTF2:
    hsa-mir-10a-5p (MIRT047578), hsa-mir-374a-5p (MIRT044014), hsa-mir-183-5p (MIRT047128), hsa-mir-98-5p (MIRT027495), hsa-mir-19a-3p (MIRT050645), hsa-mir-24-3p (MIRT030417)

    Block miRNA regulation of human, mouse, rat MTF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTF2 (see all 75):
    hsa-miR-124* hsa-miR-200a hsa-miR-485-3p hsa-miR-208b hsa-miR-4325 hsa-miR-29a* hsa-miR-155* hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidMTF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTF2
    Predesigned siRNA for gene silencing in human, mouse, rat MTF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTF2

    Clone
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    OriGene clones in human, mouse for MTF2 (see all 22)
    OriGene ORF clones in mouse, rat for MTF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MTF2 (NM_007358)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTF2_HUMAN, Q9Y483: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8619255
    GO:0005737cytoplasm IDA8619255
    GO:0035098colocalizes with ESC/E(Z) complex ISS--

    MTF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for MTF2
        PRC2 methylates histones and DNA



    MTF2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MTF2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTF2 (Q9Y4832, 3 ENSP000003593214) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-61716 I2D: score=3 STRING: ENSP00000332973
    GSK3BP498412, 3MINT-8257504 I2D: score=2 
    PRKD2Q9BZL62, 3MINT-61754 I2D: score=2 
    EZH2Q159103, ENSP000003201474I2D: score=5 STRING: ENSP00000320147
    EEDO755303, ENSP000002633604I2D: score=4 STRING: ENSP00000263360
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0007379segment specification ISS--
    GO:0016568chromatin modification IEA--
    GO:0019827stem cell maintenance ISS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ISS--

    MTF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTF2

    2 Novoseek inferred chemical compound relationships for MTF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 34 2 7866428 (1), 8288222 (1)
    zinc 21 1 7866428 (1)



    MTF2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTF2 gene (4 alternative transcripts): 
    NM_001164391.1  NM_001164392.1  NM_001164393.1  NM_007358.3  

    Unigene Cluster for MTF2:

    Metal response element binding transcription factor 2
    Hs.31016  [show with all ESTs]
    Unigene Representative Sequence: NM_007358
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370298(uc009wdj.3 uc009wdk.3 uc001dpi.4 uc001dpl.4 uc001dpm.4)
    ENST00000474314 ENST00000473430 ENST00000494963 ENST00000471953 ENST00000370303
    ENST00000467953 ENST00000497976 ENST00000468457 ENST00000476037 ENST00000487263
    ENST00000489480 ENST00000545708(uc010oth.2) ENST00000540243(uc010oti.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTF2 (see all 75):
    hsa-miR-124* hsa-miR-200a hsa-miR-485-3p hsa-miR-208b hsa-miR-4325 hsa-miR-29a* hsa-miR-155* hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidMTF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTF2
    Predesigned siRNA for gene silencing in human, mouse, rat MTF2
    Clone
    Products:
         
    OriGene clones in human, mouse for MTF2 (see all 22)
    OriGene ORF clones in mouse, rat for MTF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MTF2 (NM_007358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MTF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTF2
      QuantiTect SYBR Green Assays in human, mouse, rat MTF2
      QuantiFast Probe-based Assays in human, mouse, rat MTF2

    Additional mRNA sequence: 

    AF072814.1 AF073293.1 AF086050.1 AJ010014.1 AK290318.1 AK302776.1 AK302900.1 BC001897.1 
    BC010013.2 

    15 DOTS entries:

    DT.316179  DT.97805096  DT.91760618  DT.91760625  DT.100779621  DT.92007124  DT.100638816  DT.100658980 
    DT.97816959  DT.91760627  DT.121441792  DT.121441808  DT.70101948  DT.99996725  DT.99947352 

    Selected AceView cDNA sequences (see all 236):

    CR599562 H12670 BF594687 AI351621 AW197459 BE504302 AL704937 H10962 
    BU688255 BP367805 BF515850 BX509600 AI184381 CA843666 AI867226 BX951366 
    AA598589 AA594512 CA843415 BC001897 CA311156 BQ549270 AA804796 BU581154 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                          -                                                                                                                           
    SP2:                                                                                            -                                                         
    SP3:                          -                                                                                                                           
    SP4:                          -     -     -     -     -                                                                                                   
    SP5:                                                                                                                          -                           


    ECgene alternative splicing isoforms for MTF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGATGT
    MTF2 Expression
    About this image


    MTF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    MTF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31016
        Pathway & Disease-focused RT2 Profiler PCR Array including MTF2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MTF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTF2
    QuantiTect SYBR Green Assays in human, mouse, rat MTF2
    QuantiFast Probe-based Assays in human, mouse, rat MTF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTF2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtf21 , 5 metal response element binding transcription factor more1, 5 95.5(n)1
    97.64(a)1
      5 (52.41 cM)5
    177651  NM_013827.31  NP_038855.21 
     1080656745 
    chicken
    (Gallus gallus)
    Aves MTF21 metal response element binding transcription factor more 87.95(n)
    90.54(a)
      395174  NM_204508.1  NP_989839.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTF26
    metal response element binding transcription facto...
    88(a)
    1 ↔ 1
    4(88159460-88188244)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.119552 Xenopus laevis XPcl2 mRNA for polycomblike 2, complete more 79.88(n)    AB050540.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.135822 Transcribed sequence with moderate similarity to protein more 77.46(n)    BI839948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pcl6
    Polycomblike
    14(a)
    1 → many
    2R(14022919-14027495)


    ENSEMBL Gene Tree for MTF2 (if available)
    TreeFam Gene Tree for MTF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTF2 gene
    PHF192  PHF12  
    2 SIMAP similar genes for MTF2 using alignment to 3 protein entries:     MTF2_HUMAN (see all proteins):
    PHF19    PHF1

    MTF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTF2 (see all 1096)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18322501,2
    C,F,H--93542798(-) GCAGTC/TTGAGC 4 -- us2k110Minor allele frequency- T:0.01NS EA NA 964
    rs1836575981,2
    --93542939(+) GTCCTA/TAAATC 4 -- us2k10--------
    rs599733491,2
    C,F--93542983(+) CACACG/ATTTGC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1487088481,2
    --93543001(+) AATAAC/TACTTT 4 -- us2k10--------
    rs1395316871,2
    --93543032(+) TACTTC/TTCTAA 4 -- us2k10--------
    rs1873835731,2
    --93543068(+) TGTAGC/TCAAAG 4 -- us2k10--------
    rs1920866981,2
    C--93543112(+) GAATGA/CGTCTG 4 -- us2k10--------
    rs120670051,2
    C,F,A,H--93543119(+) TCTGAA/GGTATT 4 -- us2k126Minor allele frequency- G:0.13NS EA NA WA CSA 2468
    rs37541841,2
    C,F,H--93543483(+) CCCGAC/GTAGCT 4 -- us2k15Minor allele frequency- G:0.42NA 12
    rs1828428041,2
    --93543498(+) TTACAA/GGCATG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTF2 (93544792 - 93604638 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MTF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1866CNV Insertion18451855
    nsv508404CNV Loss20534489
    nsv830614CNV Loss17160897
    nsv830625CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTF2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609882    OMIM disorders: --

    6 diseases for MTF2:    
    About MalaCards
    endometrial stromal sarcoma    cholera    sarcoma    alzheimer's disease
    pancreatitis    cerebritis


    MTF2 for disorders           About GeneDecksing


    Export disorders for MTF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTF2 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with MTF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PubMed id 15563832)1, 3 Wang S.... Zhu J. (Gene 2004)
    2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    3. Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3. (PubMed id 23228662)2 Qin S.... Min J. (Biochem. Biophys. Res. Commun. 2013)
    4. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. (PubMed id 23142980)2 Musselman C.A.... Kutateladze T.G. (Nat. Struct. Mol. Biol. 2012)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Jarid2 and PRC2, partners in regulating gene expression. (PubMed id 20123894)1 Li G....Reinberg D. (amp 2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22823 HGNC: 29535 AceView: M96 Ensembl:ENSG00000143033 euGenes: HUgn22823
    ECgene: MTF2 H-InvDB: MTF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MTF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTF2 gene:
    Search GeneIP for patents involving MTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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