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Aliases for MTF2 Gene

Aliases for MTF2 Gene

  • Metal Response Element Binding Transcription Factor 2 2 3 5
  • Metal-Response Element DNA-Binding Protein M96 3 4
  • Metal Regulatory Transcription Factor 2 3 4
  • Tudor Domain Containing 19A 2 3
  • Polycomb-Like Protein 2 3 4
  • Polycomb-Like 2 2 3
  • HPCL2 3 4
  • PCL2 3 4
  • Metal-Response Element-Binding Transcription Factor 2 3
  • Putative DNA Binding Protein 3
  • DJ976O13.2 3
  • TDRD19A 3
  • M96 3

External Ids for MTF2 Gene

Previous GeneCards Identifiers for MTF2 Gene

  • GC01P093258
  • GC01P093317
  • GC01P093544
  • GC01P091666

Summaries for MTF2 Gene

GeneCards Summary for MTF2 Gene

MTF2 (Metal Response Element Binding Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Copper homeostasis and Mesodermal Commitment Pathway. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF19.

UniProtKB/Swiss-Prot for MTF2 Gene

  • Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTF2 Gene

Genomics for MTF2 Gene

Regulatory Elements for MTF2 Gene

Enhancers for MTF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G092975 1.5 FANTOM5 ENCODE dbSUPER 10.6 -102.8 -102826 5.3 HDGF ATF1 PKNOX1 MLX ZFP64 E2F7 TCF12 ZNF121 ZNF766 GATA2 RPL5 TRR-TCT1-1 DNTTIP2 ENSG00000230439 MTF2 EVI5 KIAA1107 SNORD21 FAM69A CCDC18-AS1
GH01G093032 1.2 Ensembl ENCODE 11 -45.5 -45493 1.5 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ZNF263 JUNB TBX21 RNU6-210P MTF2 RNU6-970P RPL5 ENSG00000207022 ENSG00000251837 GC01M093028 GC01M093059
GH01G093041 1 Ensembl ENCODE 11.3 -36.6 -36617 1.4 BCOR IRF2 FOXA2 ATF1 SAP130 ARNT ZNF316 POLR2A NFYB STAT2 FAM69A MTF2 SNORA66 SNORD21 RPL5 EVI5 ENSG00000251837 GC01M093028 GC01M093059
GH01G092973 1 ENCODE dbSUPER 10.6 -105.5 -105537 0.2 HDAC1 SMARCE1 TAL1 DPF2 ZEB2 ARID1B TCF12 ZNF766 GATA2 SMARCA4 MTF2 RPL5 RN7SL692P RNU6-970P
GH01G093221 0.9 ENCODE 10.1 +142.9 142909 1.1 FOXA2 MLX DMAP1 RAD21 ZEB1 RARA GATA2 ZNF366 CREM MIXL1 CCDC18 TMED5 MTF2 ENSG00000225297 LOC100130531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTF2 on UCSC Golden Path with GeneCards custom track

Promoters for MTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009901 765 2801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548

Genomic Location for MTF2 Gene

Chromosome:
1
Start:
93,079,235 bp from pter
End:
93,139,081 bp from pter
Size:
59,847 bases
Orientation:
Plus strand

Genomic View for MTF2 Gene

Genes around MTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTF2 Gene

Proteins for MTF2 Gene

  • Protein details for MTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y483-MTF2_HUMAN
    Recommended name:
    Metal-response element-binding transcription factor 2
    Protein Accession:
    Q9Y483
    Secondary Accessions:
    • A6NGQ9
    • A8K2Q3
    • B1AKT5
    • B1AKT6
    • Q9UES9
    • Q9UP40

    Protein attributes for MTF2 Gene

    Size:
    593 amino acids
    Molecular mass:
    67106 Da
    Quaternary structure:
    • Associated component of the PRC2 complex.

    Alternative splice isoforms for MTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTF2 Gene

Post-translational modifications for MTF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTF2 Gene

Domains & Families for MTF2 Gene

Gene Families for MTF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y483

UniProtKB/Swiss-Prot:

MTF2_HUMAN :
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).
  • Belongs to the Polycomblike family.
Domain:
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).
Family:
  • Belongs to the Polycomblike family.
genes like me logo Genes that share domains with MTF2: view

Function for MTF2 Gene

Molecular function for MTF2 Gene

UniProtKB/Swiss-Prot Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

Gene Ontology (GO) - Molecular Function for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 23142980
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MTF2: view
genes like me logo Genes that share phenotypes with MTF2: view

Animal Models for MTF2 Gene

MGI Knock Outs for MTF2:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTF2 Gene

Localization for MTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTF2 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 8619255
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 8619255
GO:0035098 colocalizes_with ESC/E(Z) complex IEA,ISS --
genes like me logo Genes that share ontologies with MTF2: view

Pathways & Interactions for MTF2 Gene

genes like me logo Genes that share pathways with MTF2: view

Gene Ontology (GO) - Biological Process for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0007379 segment specification IEA,ISS --
GO:0016569 covalent chromatin modification IEA --
GO:0019827 stem cell population maintenance ISS,IEA --
GO:0045814 negative regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with MTF2: view

No data available for SIGNOR curated interactions for MTF2 Gene

Drugs & Compounds for MTF2 Gene

(2) Drugs for MTF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTF2: view

Transcripts for MTF2 Gene

Unigene Clusters for MTF2 Gene

Metal response element binding transcription factor 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for MTF2 Gene

GeneLoc Exon Structure for
MTF2
ECgene alternative splicing isoforms for
MTF2

Expression for MTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTF2 Gene

This gene is overexpressed in Adipocyte (37.9), Peripheral blood mononuclear cells (10.0), and Testis (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTF2 Gene



Protein tissue co-expression partners for MTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTF2 Gene:

MTF2

SOURCE GeneReport for Unigene cluster for MTF2 Gene:

Hs.31016

Evidence on tissue expression from TISSUES for MTF2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with MTF2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTF2 Gene

Orthologs for MTF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTF2 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia MTF2 34 35
  • 97.98 (n)
cow
(Bos Taurus)
Mammalia MTF2 34 35
  • 97.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mtf2 34 16 35
  • 95.5 (n)
oppossum
(Monodelphis domestica)
Mammalia MTF2 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtf2 34
  • 94.04 (n)
chicken
(Gallus gallus)
Aves MTF2 34 35
  • 87.95 (n)
lizard
(Anolis carolinensis)
Reptilia MTF2 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtf2 34
  • 78.46 (n)
Str.16662 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11955 34
zebrafish
(Danio rerio)
Actinopterygii mtf2 34 35
  • 65.06 (n)
Dr.13582 34
fruit fly
(Drosophila melanogaster)
Insecta Pcl 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6624 35
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.880 34
Species where no ortholog for MTF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTF2 Gene

ENSEMBL:
Gene Tree for MTF2 (if available)
TreeFam:
Gene Tree for MTF2 (if available)

Paralogs for MTF2 Gene

Paralogs for MTF2 Gene

(2) SIMAP similar genes for MTF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTF2: view

Variants for MTF2 Gene

Sequence variations from dbSNP and Humsavar for MTF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000180798 -- 93,122,635(+) AATTA(C/T)TTCCA intron-variant, utr-variant-3-prime
rs1000195800 -- 93,096,171(+) TCACA(C/T)GTAAC intron-variant
rs1000211169 -- 93,078,480(+) GCATA(A/T)TATGG upstream-variant-2KB
rs1000243893 -- 93,078,164(+) AATTT(A/G)TGAGA upstream-variant-2KB
rs1000280735 -- 93,115,785(+) ATCTA(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTF2 Gene

Variant ID Type Subtype PubMed ID
nsv1008602 CNV gain 25217958
nsv1866 CNV insertion 18451855
nsv475764 CNV novel sequence insertion 20440878
nsv508404 CNV deletion 20534489
nsv830614 CNV loss 17160897
nsv830625 CNV loss 17160897

Variation tolerance for MTF2 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTF2 Gene

Disorders for MTF2 Gene

Relevant External Links for MTF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTF2

No disorders were found for MTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTF2 Gene

Publications for MTF2 Gene

  1. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. (PMID: 23142980) Musselman C.A. … Kutateladze T.G. (Nat. Struct. Mol. Biol. 2012) 3 4 64
  2. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PMID: 15563832) Wang S. … Zhu J. (Gene 2004) 2 3 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3. (PMID: 25923537) Gatchalian J. … Kutateladze T.G. (Epigenetics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MTF2 Gene

Sources for MTF2 Gene

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