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Aliases for MTF2 Gene

Aliases for MTF2 Gene

  • Metal Response Element Binding Transcription Factor 2 2 3 5
  • Metal-Response Element DNA-Binding Protein M96 3 4
  • Metal Regulatory Transcription Factor 2 3 4
  • Tudor Domain Containing 19A 2 3
  • Polycomb-Like Protein 2 3 4
  • Polycomb-Like 2 2 3
  • HPCL2 3 4
  • PCL2 3 4
  • Metal Response Element-Binding Transcription Factor 2 3
  • Putative DNA Binding Protein 3
  • DJ976O13.2 3
  • TDRD19A 3
  • M96 3

External Ids for MTF2 Gene

Previous GeneCards Identifiers for MTF2 Gene

  • GC01P093258
  • GC01P093317
  • GC01P093544
  • GC01P091666

Summaries for MTF2 Gene

GeneCards Summary for MTF2 Gene

MTF2 (Metal Response Element Binding Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF1.

UniProtKB/Swiss-Prot for MTF2 Gene

  • Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTF2 Gene

Genomics for MTF2 Gene

Regulatory Elements for MTF2 Gene

Promoters for MTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTF2 Gene

Chromosome:
1
Start:
93,079,235 bp from pter
End:
93,139,081 bp from pter
Size:
59,847 bases
Orientation:
Plus strand

Genomic View for MTF2 Gene

Genes around MTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTF2 Gene

Proteins for MTF2 Gene

  • Protein details for MTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y483-MTF2_HUMAN
    Recommended name:
    Metal-response element-binding transcription factor 2
    Protein Accession:
    Q9Y483
    Secondary Accessions:
    • A6NGQ9
    • A8K2Q3
    • B1AKT5
    • B1AKT6
    • Q9UES9
    • Q9UP40

    Protein attributes for MTF2 Gene

    Size:
    593 amino acids
    Molecular mass:
    67106 Da
    Quaternary structure:
    • Associated component of the PRC2 complex.

    Alternative splice isoforms for MTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTF2 Gene

Proteomics data for MTF2 Gene at MOPED

Post-translational modifications for MTF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTF2 Gene

No data available for DME Specific Peptides for MTF2 Gene

Domains & Families for MTF2 Gene

Gene Families for MTF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y483

UniProtKB/Swiss-Prot:

MTF2_HUMAN :
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).
  • Belongs to the Polycomblike family.
  • Contains 2 PHD-type zinc fingers.
Domain:
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).
  • Contains 1 Tudor domain.
Family:
  • Belongs to the Polycomblike family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with MTF2: view

Function for MTF2 Gene

Molecular function for MTF2 Gene

UniProtKB/Swiss-Prot Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
genes like me logo Genes that share phenotypes with MTF2: view

Animal Models for MTF2 Gene

MGI Knock Outs for MTF2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTF2 Gene

Localization for MTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTF2 Gene COMPARTMENTS Subcellular localization image for MTF2 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 8619255
genes like me logo Genes that share ontologies with MTF2: view

Pathways & Interactions for MTF2 Gene

genes like me logo Genes that share pathways with MTF2: view

Pathways by source for MTF2 Gene

Gene Ontology (GO) - Biological Process for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0010467 gene expression TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,ISS --
GO:0048863 stem cell differentiation IEA,ISS --
GO:0061086 negative regulation of histone H3-K27 methylation IEA,ISS --
genes like me logo Genes that share ontologies with MTF2: view

No data available for SIGNOR curated interactions for MTF2 Gene

Drugs & Compounds for MTF2 Gene

(2) Drugs for MTF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTF2: view

Transcripts for MTF2 Gene

Unigene Clusters for MTF2 Gene

Metal response element binding transcription factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for MTF2 Gene

GeneLoc Exon Structure for
MTF2
ECgene alternative splicing isoforms for
MTF2

Expression for MTF2 Gene

mRNA expression in normal human tissues for MTF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTF2 Gene

This gene is overexpressed in Adipocyte (37.9), Peripheral blood mononuclear cells (10.0), and Testis (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTF2 Gene



SOURCE GeneReport for Unigene cluster for MTF2 Gene Hs.31016

genes like me logo Genes that share expression patterns with MTF2: view

Protein tissue co-expression partners for MTF2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTF2 Gene

Orthologs for MTF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTF2 36
  • 100 (a)
OneToOne
MTF2 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia MTF2 36
  • 99 (a)
OneToOne
MTF2 35
  • 97.83 (n)
  • 99.39 (a)
dog
(Canis familiaris)
Mammalia MTF2 35
  • 97.98 (n)
  • 99.49 (a)
MTF2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtf2 16
Mtf2 35
  • 95.5 (n)
  • 97.64 (a)
Mtf2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTF2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mtf2 35
  • 94.04 (n)
  • 96.96 (a)
chicken
(Gallus gallus)
Aves MTF2 35
  • 87.95 (n)
  • 90.54 (a)
MTF2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTF2 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11955 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mtf2 35
  • 78.46 (n)
  • 76.75 (a)
Str.16662 35
zebrafish
(Danio rerio)
Actinopterygii mtf2 36
  • 63 (a)
OneToOne
Dr.13582 35
mtf2 35
  • 65.06 (n)
  • 66.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pcl 36
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.880 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6624 36
  • 37 (a)
OneToMany
Species with no ortholog for MTF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTF2 Gene

ENSEMBL:
Gene Tree for MTF2 (if available)
TreeFam:
Gene Tree for MTF2 (if available)

Paralogs for MTF2 Gene

Paralogs for MTF2 Gene

(2) SIMAP similar genes for MTF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTF2: view

Variants for MTF2 Gene

Sequence variations from dbSNP and Humsavar for MTF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2815427 - 93,115,024(+) TGATT(C/G)CAGTG reference, missense, utr-variant-5-prime
rs482122 -- 93,103,026(-) gcctc(C/T)caagt intron-variant
rs494745 -- 93,110,745(-) CTCCT(A/C)GGAAG intron-variant
rs556446 -- 93,101,960(-) TTTCA(A/G)TTTAA intron-variant
rs574855 -- 93,112,967(-) GGAAC(A/G)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTF2 Gene

Variant ID Type Subtype PubMed ID
nsv830614 CNV Loss 17160897
nsv508404 CNV Loss 20534489
nsv1866 CNV Insertion 18451855
nsv830625 CNV Loss 17160897

Variation tolerance for MTF2 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTF2 Gene

HapMap Linkage Disequilibrium report
MTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTF2 Gene

Disorders for MTF2 Gene

Relevant External Links for MTF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTF2

No disorders were found for MTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTF2 Gene

Publications for MTF2 Gene

  1. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. (PMID: 23142980) Musselman C.A. … Kutateladze T.G. (Nat. Struct. Mol. Biol. 2012) 3 4 67
  2. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PMID: 15563832) Wang S. … Zhu J. (Gene 2004) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for MTF2 Gene

Sources for MTF2 Gene

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