Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTF2 Gene

Aliases for MTF2 Gene

  • Metal Response Element Binding Transcription Factor 2 2 3
  • PCL2 3 4 6
  • Metal-Response Element DNA-Binding Protein M96 3 4
  • Metal Regulatory Transcription Factor 2 3 4
  • Tudor Domain Containing 19A 2 3
  • Polycomb-Like Protein 2 3 4
  • Polycomb-Like 2 2 3
  • HPCl2 3 4
  • M96 3 6
  • Metal Response Element-Binding Transcription Factor 2 3
  • Metal-Response Element-Binding Transcription Factor 2 3
  • Putative DNA Binding Protein 3
  • DJ976O13.2 3
  • TDRD19A 3

External Ids for MTF2 Gene

Previous GeneCards Identifiers for MTF2 Gene

  • GC01P093258
  • GC01P093317
  • GC01P093544
  • GC01P091666

Summaries for MTF2 Gene

GeneCards Summary for MTF2 Gene

MTF2 (Metal Response Element Binding Transcription Factor 2) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF19.

UniProtKB/Swiss-Prot for MTF2 Gene

  • Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTF2 Gene

Genomics for MTF2 Gene

Regulatory Elements for MTF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTF2 Gene

Start:
93,079,235 bp from pter
End:
93,139,081 bp from pter
Size:
59,847 bases
Orientation:
Plus strand

Genomic View for MTF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTF2 Gene

Proteins for MTF2 Gene

  • Protein details for MTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y483-MTF2_HUMAN
    Recommended name:
    Metal-response element-binding transcription factor 2
    Protein Accession:
    Q9Y483
    Secondary Accessions:
    • A6NGQ9
    • A8K2Q3
    • B1AKT5
    • B1AKT6
    • Q9UES9
    • Q9UP40

    Protein attributes for MTF2 Gene

    Size:
    593 amino acids
    Molecular mass:
    67106 Da
    Quaternary structure:
    • Associated component of the PRC2 complex.

    Alternative splice isoforms for MTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTF2 Gene

Proteomics data for MTF2 Gene at MOPED

Post-translational modifications for MTF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTF2 Gene

No data available for DME Specific Peptides for MTF2 Gene

Domains for MTF2 Gene

Gene Families for MTF2 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type
  • TDRD :Tudor domain containing

Graphical View of Domain Structure for InterPro Entry

Q9Y483

UniProtKB/Swiss-Prot:

MTF2_HUMAN :
  • Q9Y483
Domain:
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).
  • Contains 1 Tudor domain.
Family:
  • Belongs to the Polycomblike family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with MTF2: view

Function for MTF2 Gene

Molecular function for MTF2 Gene

UniProtKB/Swiss-Prot Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

Gene Ontology (GO) - Molecular Function for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0035064 methylated histone binding IDA 23142980
genes like me logo Genes that share ontologies with MTF2: view
genes like me logo Genes that share phenotypes with MTF2: view

Animal Models for MTF2 Gene

MGI Knock Outs for MTF2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTF2 Gene

Localization for MTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTF2 Gene COMPARTMENTS Subcellular localization image for MTF2 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8619255
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 8619255
GO:0035098 colocalizes_with ESC/E(Z) complex ISS --
genes like me logo Genes that share ontologies with MTF2: view

Pathways for MTF2 Gene

SuperPathways for MTF2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for MTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0007379 segment specification ISS --
GO:0010467 gene expression TAS --
GO:0016568 chromatin modification IEA --
GO:0019827 stem cell maintenance ISS --
genes like me logo Genes that share ontologies with MTF2: view

No data available for Pathways by source for MTF2 Gene

Compounds for MTF2 Gene

(2) Novoseek inferred chemical compound relationships for MTF2 Gene

Compound -log(P) Hits PubMed IDs
leucine 34 2
zinc 21 1
genes like me logo Genes that share compounds with MTF2: view

Transcripts for MTF2 Gene

Unigene Clusters for MTF2 Gene

Metal response element binding transcription factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: -
SP4: - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for MTF2 Gene

GeneLoc Exon Structure for
MTF2
ECgene alternative splicing isoforms for
MTF2

Expression for MTF2 Gene

mRNA expression in normal human tissues for MTF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MTF2 Gene

This gene is overexpressed in Adipocyte (37.9), Peripheral blood mononuclear cells (10.0), and Testis (10.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTF2 Gene

SOURCE GeneReport for Unigene cluster for MTF2 Gene Hs.31016

genes like me logo Genes that share expressions with MTF2: view

Expression partners for MTF2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTF2 Gene

Orthologs for MTF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTF2 35
  • 97.83 (n)
  • 99.39 (a)
MTF2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTF2 35
  • 97.98 (n)
  • 99.49 (a)
MTF2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtf2 35
  • 95.5 (n)
  • 97.64 (a)
Mtf2 16
Mtf2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTF2 35
  • 100 (n)
  • 100 (a)
MTF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtf2 35
  • 94.04 (n)
  • 96.96 (a)
oppossum
(Monodelphis domestica)
Mammalia MTF2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves MTF2 35
  • 87.95 (n)
  • 90.54 (a)
MTF2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTF2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtf2 35
  • 78.46 (n)
  • 76.75 (a)
Str.16662 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11955 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13582 35
mtf2 35
  • 65.06 (n)
  • 66.61 (a)
mtf2 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pcl 36
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.880 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6624 36
  • 37 (a)
OneToMany
Species with no ortholog for MTF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTF2 Gene

ENSEMBL:
Gene Tree for MTF2 (if available)
TreeFam:
Gene Tree for MTF2 (if available)

Paralogs for MTF2 Gene

Paralogs for MTF2 Gene

Selected SIMAP similar genes for MTF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTF2: view

Variants for MTF2 Gene

Sequence variations from dbSNP and Humsavar for MTF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs475120 -- 93,107,696(-) AAGGT(A/C)AATAT intron-variant
rs482122 -- 93,103,026(-) gcctc(C/T)caagt intron-variant
rs484126 -- 93,114,675(-) ATTTA(A/C)AACAC intron-variant
rs488345 -- 93,092,479(-) ACAGA(A/C)AAGAA intron-variant
rs489183 -- 93,127,135(-) AAGTG(A/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTF2 Gene

Variant ID Type Subtype PubMed ID
nsv830614 CNV Loss 17160897
nsv508404 CNV Loss 20534489
nsv1866 CNV Insertion 18451855
nsv830625 CNV Loss 17160897

Relevant External Links for MTF2 Gene

HapMap Linkage Disequilibrium report
MTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTF2 Gene

Disorders for MTF2 Gene

No disorders were found for MTF2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MTF2 Gene

Publications for MTF2 Gene

  1. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PMID: 15563832) Wang S. … Zhu J. (Gene 2004) 2 3
  2. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. (PMID: 23142980) Musselman C.A. … Kutateladze T.G. (Nat. Struct. Mol. Biol. 2012) 3 4
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for MTF2 Gene

Sources for MTF2 Gene

Back to Top

Content