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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTF2 Gene

protein-coding   GIFtS: 51
GCID: GC01P093544

metal response element binding transcription factor 2
 Explore 5 diseases affiliated with
MTF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MTF2    

Aliases
for MTF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metal Response Element Binding Transcription Factor 21 2     RP5-976O13.12
PCL21 2 3 5     DJ976O13.21
M961 2 5     Metal Response Element-Binding Transcription Factor 22
TDRD19A1 2     Metal-Response Element-Binding Transcription Factor 22
Metal Regulatory Transcription Factor 22 3     Polycomb-Like 22
Metal-Response Element DNA-Binding Protein M962 3     Putative DNA Binding Protein2
Polycomb-Like Protein 22 3     Tudor Domain Containing 19A2
HPCl21     

External Ids:    HGNC: 295351   Entrez Gene: 228232   Ensembl: ENSG000001430337   OMIM: 6098825   UniProtKB: Q9Y4833   

Export aliases for MTF2 gene to outside databases

Previous GC identifers: GC01P093258 GC01P093317 GC01P091666


Summaries
for MTF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483
Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the
PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex,
leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem
cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in
differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox
genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2
activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of
the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity)




Genomic Views
for MTF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTF2 gene promoter:
         GCNF   p300   HSF1 (long)   MZF-1   CREB   GCNF-1   IRF-7A   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MTF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

MTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P093544:  view genomic region     (about GC identifiers)

Start:
 93,544,792 bp from pter      End:
 93,604,638 bp from pter
Size:
 59,847 bases      Orientation:
 plus strand

Proteins
for MTF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483 (See protein sequence)
Recommended Name: Metal-response element-binding transcription factor 2  
Size: 593 amino acids; 67106 Da
Subunit: Associated component of the PRC2 complex (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: A6NGQ9 A8K2Q3 B1AKT5 Q9UES9 Q9UP40
Alternative splicing: 3 isoforms:  Q9Y483-1   Q9Y483-2   Q9Y483-3   

Explore the universe of human proteins at neXtProt for MTF2: NX_Q9Y483

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y483

    • MTF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157863.1  NP_001157864.1  NP_001157865.1  NP_031384.1  

    ENSEMBL proteins: 
     ENSP00000359321   ENSP00000359326   ENSP00000444962   ENSP00000443295  

    Human Recombinant Protein Products: 
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    Novus Biologicals MTF2 Protein
    Novus Biologicals MTF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTF2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8619255
    GO:0005737cytoplasm IDA8619255


    MTF2 for ontologies           About GeneDecksing



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    Uscn Antibodies for MTF2
    Search ThermoFisher Antibodies for MTF2

    Assay Products for MTF2: 
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    Uscn ELISAs and CLIAs for MTF2

    Protein Domains /
    Families
    for MTF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MTF2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR025894 Mtf2_C_dom
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y483

    ProtoNet protein and cluster: Q9Y483

    2 Blocks protein families:
    IPB001965 Zn-finger-like
    IPB002999 Tudor domain


    UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483
    Domain: The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662)
    Similarity: Belongs to the Polycomblike family
    Similarity: Contains 2 PHD-type zinc fingers
    Similarity: Contains 1 Tudor domain


    Function
    for MTF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MTF2_HUMAN, Q9Y483
    Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the
    PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex,
    leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem
    cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in
    differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox
    genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2
    activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of
    the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity)

    miRNA
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    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate MTF2 (see all 75):
    hsa-miR-124* hsa-miR-200a hsa-miR-485-3p hsa-miR-208b hsa-miR-4325 hsa-miR-29a* hsa-miR-155* hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: MTF2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTF2 (see all 7)
    OriGene shRNA RFP: MTF2
    OriGene siRNA: MTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTF2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MTF2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTF2 (see all 6)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF2 

    Cell Line
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    Search LifeMap BioReagents cell lines for MTF2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    MTF2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MTF2:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Mtf2tm1.1Hko for MTF2
         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mtf2):
     cellular  craniofacial  embryogenesis  growth/size  limbs/digits/tail 
     mortality/aging  nervous system  reproductive system  skeleton 

    MTF2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MTF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/26 Interacting proteins for MTF2 (Q9Y4832, 3 ENSP000003593214) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-61716 I2D: score=3 STRING: ENSP00000332973
    GSK3BP498412, 3MINT-8257504 I2D: score=2 
    PRKD2Q9BZL62, 3MINT-61754 I2D: score=2 
    EZH2Q159103, ENSP000003201474I2D: score=5 STRING: ENSP00000320147
    EEDO755303, ENSP000002633604I2D: score=4 STRING: ENSP00000263360
    About this table

    Drugs & Compounds
    for MTF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTF2
    2 Novoseek chemical compound relationships for MTF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 34 2 7866428 (1), 8288222 (1)
    zinc 21 1 7866428 (1)

    Search CenterWatch for drugs/clinical trials and news about MTF2 

    Transcripts
    for MTF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MTF2 gene (4 alternative transcripts): 
    NM_001164391.1  NM_001164392.1  NM_001164393.1  NM_007358.3  

    Unigene Cluster for MTF2:

    Metal response element binding transcription factor 2
    Hs.712767  [show with all ESTs]
    Unigene Representative Sequence: NM_007358
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370298(uc009wdj.3 uc009wdk.3 uc001dpi.4 uc001dpl.4 uc001dpm.4)
    ENST00000474314 ENST00000473430 ENST00000494963 ENST00000471953 ENST00000370303
    ENST00000467953 ENST00000497976 ENST00000468457 ENST00000476037 ENST00000487263
    ENST00000489480 ENST00000545708(uc010oth.2) ENST00000540243(uc010oti.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTF2
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate MTF2 (see all 75):
    hsa-miR-124* hsa-miR-200a hsa-miR-485-3p hsa-miR-208b hsa-miR-4325 hsa-miR-29a* hsa-miR-155* hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmid: MTF2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTF2 (see all 7)
    OriGene shRNA RFP: MTF2
    OriGene siRNA: MTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTF2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTF2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MTF2 (NM_007358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTF2

    Additional cDNA sequence: 

    AF072814.1 AF073293.1 AF086050.1 AJ010014.1 AK290318.1 AK302776.1 AK302900.1 BC001897.1 
    BC010013.2 

    15 DOTS entries:

    DT.316179  DT.97805096  DT.91760618  DT.91760625  DT.100779621  DT.92007124  DT.100638816  DT.100658980 
    DT.97816959  DT.91760627  DT.121441808  DT.70101948  DT.99996725  DT.121441792  DT.99947352 

    24/236 AceView cDNA sequences (see all 236):

    CR599562 AI351621 H12670 BF594687 AW197459 BE504302 H10962 AL704937 
    BU688255 BX509600 BF515850 BP367805 AI184381 AI867226 CA843666 BX951366 
    AA598589 AA594512 BC001897 CA843415 CA311156 BQ549270 AA804796 BU581154 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MTF2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                          -                                                                                                                           
    SP2:                                                                                            -                                                         
    SP3:                          -                                                                                                                           
    SP4:                          -     -     -     -     -                                                                                                   
    SP5:                                                                                                                          -                           


    ECgene alternative splicing isoforms for MTF2

    Expression
    for MTF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTCTGATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MTF2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MTF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTF2

    SOURCE GeneReport for Unigene cluster: Hs.712767
        SABiosciences Expression via Pathway-Focused PCR Array including MTF2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTF2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF2

    Orthologs
    for MTF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MTF2 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MTF21 metal response element binding transcription factor more 88.06(n)
    90.71(a)    		   395174  NM_204508.1  NP_989839.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MTF26
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(88171948-88184819)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.119552 Xenopus laevis XPcl2 mRNA for polycomblike 2, complete more 79.88(n)    AB050540.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.135822 Transcribed sequence with moderate similarity to protein more 77.46(n)    BI839948.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pcl1 Polycomblike 46.88(n)
    35.77(a)    		   37069  NM_057324.4  NP_476672.1 


    ENSEMBL Gene Tree for MTF2 (if available)
    TreeFam Gene Tree for MTF2 (if available) 

    Paralogs
    for MTF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTF2 gene
    PHF192  PHF12  
    2 SIMAP similar genes for MTF2 using alignment to 4 protein entries:     MTF2_HUMAN (see all proteins):
    PHF19    PHF1

    MTF2 for paralogs           About GeneDecksing



    Genomic Variants
    for MTF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/868 NCBI SNPs in MTF2 are shown (see all 868)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs676936281,2
    		C--91699503(+) TACAT-/AAAG  
                AAAAA     		1 -- int10--------
    rs18322501,2
    		C,F,H--93542798(-) GCAGTC/TTGAGC 4 -- us2k110Minor allele frequency- T:0.01NS EA NA 964
    rs1836575981,2
    		--93542939(+) GTCCTA/TAAATC 4 -- us2k10--------
    rs599733491,2
    		C,--93542983(+) CACACG/ATTTGC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1487088481,2
    		--93543001(+) AATAAC/TACTTT 4 -- us2k10--------
    rs1395316871,2
    		--93543032(+) TACTTC/TTCTAA 4 -- us2k10--------
    rs1873835731,2
    		--93543068(+) TGTAGC/TCAAAG 4 -- us2k10--------
    rs1920866981,2
    		--93543112(+) GAATGA/CGTCTG 4 -- us2k10--------
    rs120670051,2
    		C,F,A,H,--93543119(+) TCTGAA/GGTATT 4 -- us2k126Minor allele frequency- G:0.13NS EA NA WA CSA 2468
    rs37541841,2
    		C,F,H,--93543483(+) CCCGAC/GTAGCT 4 -- us2k15Minor allele frequency- G:0.42NA 12

    HapMap Linkage Disequilibrium report for MTF2 (93544792 - 93604638 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MTF2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTF2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTF2

    Disorders / Diseases
    for MTF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MTF2 for disorders           About GeneDecksing

    OMIM gene information: 609882    OMIM disorders: --

    5 diseases for MTF2:    About MalaCards
    endometrial stromal sarcoma    cholera    alzheimer's disease    sarcoma
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for MTF2:
    Endometrial stromal sarcoma

    Export disorders for MTF2 gene to outside databases

    Publications
    for MTF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTF2 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with MTF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PubMed id 15563832)1, 3 Wang S.... Zhu J. (2004)
    2. Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3. (PubMed id 23228662)2 Qin S.... Min J. (2013)
    3. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. (PubMed id 23142980)2 Musselman C.A.... Kutateladze T.G. (2012)
    4. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    5. Jarid2 and PRC2, partners in regulating gene expressi on. (PubMed id 20123894)1 Li G....Reinberg D. (2010)
    6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    External Searches for MTF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing MTF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22823 HGNC: 29535 AceView: M96 Ensembl:ENSG00000143033 euGenes: HUgn22823
    ECgene: MTF2 H-InvDB: MTF2

    Other Databases showing MTF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MTF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTF2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MTF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MTF2 gene:
    Search GeneIP for patents involving MTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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