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MTF1 Gene

protein-coding   GIFtS: 56
GCID: GC01M038275

Metal-Regulatory Transcription Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metal-Regulatory Transcription Factor 11 2     Metal Regulatory Transcription Factor 12
Transcription Factor MTF-12 3     Metal-Responsive Transcription Factor 12
MRE-Binding Transcription Factor2 3     MRE-Binding Transcription Factor-12
MTF-12     Zinc Regulatory Factor2
ZRF2     

External Ids:    HGNC: 74281   Entrez Gene: 45202   Ensembl: ENSG000001887867   OMIM: 6001725   UniProtKB: Q148723   

Export aliases for MTF1 gene to outside databases

Previous GC identifers: GC01M038114 GC01M037334 GC01M037706 GC01M9V0006 GC01M037948 GC01M038047 GC01M036393


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTF1 Gene:
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in
metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a
nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to
promoters containing a metal-responsive element (MRE). (provided by RefSeq, Jul 2008)

GeneCards Summary for MTF1 Gene:
MTF1 (metal-regulatory transcription factor 1) is a protein-coding gene. Diseases associated with MTF1 include enamel erosion, and dentine erosion. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872
Function: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)

Gene Wiki entry for MTF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTF1 gene promoter:
         p53   AP-1   AP-2alpha isoform 3   AP-2alpha isoform 2   CREB   deltaCREB   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTF1 promoter sequence
   Search Chromatin IP Primers for MTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p33

MTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038275:  view genomic region     (about GC identifiers)

Start:
38,275,239 bp from pter      End:
38,325,292 bp from pter
Size:
50,054 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872 (See protein sequence)
Recommended Name: Metal regulatory transcription factor 1  
Size: 753 amino acids; 80957 Da
Secondary accessions: B2RAK6 Q96CB1

Explore the universe of human proteins at neXtProt for MTF1: NX_Q14872

Explore proteomics data for MTF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005946.2  
    ENSEMBL proteins: 
     ENSP00000362127  

    MTF1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for MTF1

    MTF1 Assay Products:

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    Cloud-Clone Corp. CLIAs for MTF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q14872

    ProtoNet protein and cluster: Q14872

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872
    Similarity: Contains 6 C2H2-type zinc fingers


    MTF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTF1_HUMAN, Q14872
    Function: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)

         Genatlas biochemistry entry for MTF1:
    metal-regulatory transcription factor MTF-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001047core promoter binding IDA15735762
    GO:0003677DNA binding TAS8065932
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS3208749
         
    MTF1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mtf1):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  normal  tumorigenesis 

    MTF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mtf1tm1Wsc for MTF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTF1

    miRNA
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    miRTarBase miRNAs that target MTF1:
    hsa-mir-17-5p (MIRT051017), hsa-mir-103a-3p (MIRT026986), hsa-mir-590-3p (MIRT016162), hsa-mir-125b-5p (MIRT046066), hsa-mir-106a-5p (MIRT048354), hsa-mir-32-5p (MIRT028255)

    Block miRNA regulation of human, mouse, rat MTF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTF1 (see all 205):
    hsa-miR-194* hsa-miR-579 hsa-miR-100* hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat MTF1

    Gene Editing
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    Sino Biological Human cDNA Clone for MTF1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTF1_HUMAN, Q14872: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    MTF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTF1
    Interactions:

        Search GeneGlobe Interaction Network for MTF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MTF1 (Q148721, 2, 3 ENSP000003621274) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1M1Q9BXS51, 2, 3, ENSP000003889964EBI-747024,EBI-541426 MINT-66977 I2D: score=4 STRING: ENSP00000388996
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    NR4A3Q925703, ENSP000003331224I2D: score=1 STRING: ENSP00000333122
    CERS2Q96G233I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS3208749
    GO:0006979response to oxidative stress IEA--
    GO:0010038response to metal ion TAS8065932
    GO:0045893positive regulation of transcription, DNA-templated ----

    MTF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTF1

    Selected Novoseek inferred chemical compound relationships for MTF1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 77.5 119 17462582 (5), 14612393 (4), 10026134 (4), 8467794 (3) (see all 44)
    cadmium 67.5 23 10026134 (3), 19040355 (2), 19913599 (1), 11266553 (1) (see all 9)
    gamma-glutamylcysteine 58 4 11266553 (1), 15378601 (1), 18057785 (1)
    copper 57 37 15833915 (3), 19040355 (3), 11266553 (1), 20038716 (1) (see all 10)
    mercury 33.2 7 19040355 (2)
    cysteine 23.6 5 14610091 (2), 17409697 (1), 11735399 (1)
    h2o2 10.8 3 14612393 (2), 11306562 (1)
    cycloheximide 7.75 6 16615093 (2), 11306562 (1)
    proline 6.45 1 8467794 (1)
    oxygen 0 1 15544971 (1)



    MTF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTF1 gene: 
    NM_005955.2  

    Unigene Cluster for MTF1:

    Metal-regulatory transcription factor 1
    Hs.471991  [show with all ESTs]
    Unigene Representative Sequence: NM_005955
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373036(uc001cce.1 uc009vvj.1) ENST00000468190
    miRNA
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    Block miRNA regulation of human, mouse, rat MTF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTF1 (see all 205):
    hsa-miR-194* hsa-miR-579 hsa-miR-100* hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MTF1
      QuantiFast Probe-based Assays in human, mouse, rat MTF1

    Additional mRNA sequence: 

    AK125603.1 AK225923.1 AK298751.1 AK309584.1 AK314233.1 BC014454.1 X78710.1 

    6 DOTS entries:

    DT.441267  DT.101964233  DT.97770405  DT.91788107  DT.99969770  DT.87046565 

    Selected AceView cDNA sequences (see all 68):

    AI125324 BX097718 X78710 CA309684 BC014454 AA448256 NM_005955 AI024663 
    AI078549 AW057658 BP342212 BQ221975 CA748631 AA252540 AA743786 BE906486 
    BQ425250 AW057659 BI257931 AI016516 AI468051 BU664699 BF223778 BF508263 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13
    SP1:              -                                                                       -               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                      -               
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MTF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACAACGG
    MTF1 Expression
    About this image


    MTF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Hepatoblasts Liver Bud
     
     Liver (Hepatobiliary System)
             Hepatoblasts Liver Bud
    MTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471991
        Custom PCR Arrays for MTF1
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    QuantiFast Probe-based Assays in human, mouse, rat MTF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtf11 , 5 metal response element binding transcription factor more1, 5 91.23(n)1
    92.72(a)1
      4 (57.91 cM)5
    177641  NM_008636.41  NP_032662.31 
     1248021045 
    chicken
    (Gallus gallus)
    Aves MTF11 metal-regulatory transcription factor 1 78.44(n)
    80.33(a)
      428218  NM_001031495.1  NP_001026666.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTF16
    metal-regulatory transcription factor 1
    67(a)
    1 ↔ 1
    GL343426.1(567225-575736)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mtf11 metal-regulatory transcription factor 1 64.77(n)
    64.01(a)
      100495484  XM_002939479.2  XP_002939525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtf12 metal-regulatory transcription factor 1 79.51(n)   195821  AF458116.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MTF-16
    Metal response element-binding Transcription Facto...
    23(a)
    1 ↔ 1
    3L(9423412-9431811)


    ENSEMBL Gene Tree for MTF1 (if available)
    TreeFam Gene Tree for MTF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTF1 gene
    ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  ZIC12  GLIS22  GLI22  
    ZIC42  GLIS12  ZNF1432  GLIS32  ZIC52  GLI32  

    MTF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTF1 (see all 897)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850126181,2
    --38275905(+) CCTGGC/GTTTTG 1 -- ut310--------
    rs726618401,2
    --38275983(+) GACACC/TACATT 1 -- ut310--------
    rs588715861,2
    C--38276156(+) GTAAC-/AGTGAGA 1 -- ut310--------
    rs285950481,2
    F--38276380(+) AAAATC/GCTTCT 1 -- ut311Minor allele frequency- G:0.03NA 120
    rs4731861,2
    C,F,H--38276381(-) CAGAAA/GGATTT 1 -- ut3124Minor allele frequency- G:0.03EA NA MN NS WA CSA 1679
    rs1907020601,2
    --38276533(+) AGGCCC/TTTTTG 1 -- ut310--------
    rs1437031641,2
    C--38276667(+) AAATAC/TTGTTG 1 -- ut310--------
    rs1924271331,2
    C--38276678(+) CAGTTC/GCACAA 1 -- ut310--------
    rs1468056951,2
    --38276681(+) TTCCAC/GAAATC 1 -- ut310--------
    rs1396012391,2
    --38276699(+) TCAATA/CACTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTF1 (38275239 - 38325292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MTF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv506927CNV Insertion20534489
    nsv510CNV Insertion18451855
    nsv871810CNV Loss21882294
    nsv870730CNV Gain21882294

    Human Gene Mutation Database (HGMD): MTF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTF1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600172    OMIM disorders: --

    17 diseases for MTF1:    
    About MalaCards
    enamel erosion    dentine erosion    lymphosarcoma    menkes disease
    autism spectrum disorder    papillary thyroid carcinoma    hypothyroidism    hypoxia
    coronary heart disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma    thyroiditis
    neuroblastoma    cervicitis    hepatocellular carcinoma    breast cancer
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for MTF1:
    Enamel erosion     Dentine erosion

    MTF1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MTF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 15.6 4 11266553 (1), 11306562 (1), 18593933 (1), 12805380 (1)
    tumors 0 4 20087061 (1), 19956853 (1)
    lymphoma 0 4 15516976 (2), 17308060 (1)

    Genetic Association Database (GAD): MTF1
    Human Genome Epidemiology (HuGE) Navigator: MTF1 (5 documents)

    Export disorders for MTF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTF1 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with MTF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping and characterization of the human metal- regulatory transcription factor MTF-1. (PubMed id 8065932)1, 2, 3, 9 Brugnera E.... Schaffner W. (Nucleic Acids Res. 1994)
    2. Genetic susceptibility to environmental toxicants in ALS. (PubMed id 17503480)1, 4, 9 Morahan J.M....Pamphlett R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    3. Novel associations for hypothyroidism include known autoimmune risk loci. (PubMed id 22493691)1, 4 Eriksson N....Do C.B. (PLoS ONE 2012)
    4. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (PubMed id 19286843)1, 4 Akulevich N.M....Yamashita S. (Endocr. Relat. Cancer 2009)
    5. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain. (PubMed id 19797083)1, 9 Lindert U....Schaffner W. (Mol. Cell. Biol. 2009)
    10. Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. (PubMed id 11306562)1, 9 Saydam N....Schaffner W. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4520 HGNC: 7428 AceView: MTF1 Ensembl:ENSG00000188786 euGenes: HUgn4520
    ECgene: MTF1 H-InvDB: MTF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTF1 gene:
    Search GeneIP for patents involving MTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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