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Aliases for MTF1 Gene

Aliases for MTF1 Gene

  • Metal-Regulatory Transcription Factor 1 2 3 5
  • MRE-Binding Transcription Factor 3 4
  • Transcription Factor MTF-1 3 4
  • Metal-Responsive Transcription Factor 1 3
  • MRE-Binding Transcription Factor-1 3
  • Zinc Regulatory Factor 3
  • MTF-1 3
  • ZRF 3

External Ids for MTF1 Gene

Previous GeneCards Identifiers for MTF1 Gene

  • GC01M038114
  • GC01M037334
  • GC01M037706
  • GC01M9V0006
  • GC01M037948
  • GC01M038047
  • GC01M038275
  • GC01M036393

Summaries for MTF1 Gene

Entrez Gene Summary for MTF1 Gene

  • This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

GeneCards Summary for MTF1 Gene

MTF1 (Metal-Regulatory Transcription Factor 1) is a Protein Coding gene. Diseases associated with MTF1 include enamel erosion and dentine erosion. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for MTF1 Gene

  • Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Gene Wiki entry for MTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTF1 Gene

Genomics for MTF1 Gene

Regulatory Elements for MTF1 Gene

Enhancers for MTF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTF1 on UCSC Golden Path with GeneCards custom track

Promoters for MTF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTF1 Gene

Chromosome:
1
Start:
37,809,567 bp from pter
End:
37,859,624 bp from pter
Size:
50,058 bases
Orientation:
Minus strand

Genomic View for MTF1 Gene

Genes around MTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTF1 Gene

Proteins for MTF1 Gene

  • Protein details for MTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14872-MTF1_HUMAN
    Recommended name:
    Metal regulatory transcription factor 1
    Protein Accession:
    Q14872
    Secondary Accessions:
    • B2RAK6
    • Q96CB1

    Protein attributes for MTF1 Gene

    Size:
    753 amino acids
    Molecular mass:
    80957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTF1 Gene

Proteomics data for MTF1 Gene at MOPED

Post-translational modifications for MTF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTF1 Gene

Domains & Families for MTF1 Gene

Protein Domains for MTF1 Gene

Suggested Antigen Peptide Sequences for MTF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14872

UniProtKB/Swiss-Prot:

MTF1_HUMAN :
  • Contains 6 C2H2-type zinc fingers.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MTF1: view

No data available for Gene Families for MTF1 Gene

Function for MTF1 Gene

Molecular function for MTF1 Gene

GENATLAS Biochemistry:
metal-regulatory transcription factor MTF-1
UniProtKB/Swiss-Prot Function:
Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Gene Ontology (GO) - Molecular Function for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9582278
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 3208749
GO:0005515 protein binding IPI 16189514
GO:0035035 histone acetyltransferase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MTF1: view
genes like me logo Genes that share phenotypes with MTF1: view

Animal Models for MTF1 Gene

MGI Knock Outs for MTF1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTF1 Gene

Localization for MTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTF1 Gene COMPARTMENTS Subcellular localization image for MTF1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for MTF1 Gene

Pathways & Interactions for MTF1 Gene

genes like me logo Genes that share pathways with MTF1: view

Gene Ontology (GO) - Biological Process for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0046686 response to cadmium ion IEA --
genes like me logo Genes that share ontologies with MTF1: view

No data available for SIGNOR curated interactions for MTF1 Gene

Drugs & Compounds for MTF1 Gene

(8) Drugs for MTF1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LOR-253 Pharma 0

(6) Additional Compounds for MTF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MTF1: view

Transcripts for MTF1 Gene

Unigene Clusters for MTF1 Gene

Metal-regulatory transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for MTF1 Gene

GeneLoc Exon Structure for
MTF1
ECgene alternative splicing isoforms for
MTF1

Expression for MTF1 Gene

mRNA expression in normal human tissues for MTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTF1 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for MTF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.7) and Placenta (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTF1 Gene



SOURCE GeneReport for Unigene cluster for MTF1 Gene Hs.471991

genes like me logo Genes that share expression patterns with MTF1: view

Protein tissue co-expression partners for MTF1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MTF1 Gene

Orthologs for MTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTF1 35
  • 91.83 (n)
  • 91.34 (a)
MTF1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTF1 35
  • 93.83 (n)
  • 95.3 (a)
MTF1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtf1 35
  • 91.23 (n)
  • 92.72 (a)
Mtf1 16
Mtf1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTF1 35
  • 99.73 (n)
  • 99.73 (a)
MTF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtf1 35
  • 91.73 (n)
  • 93.16 (a)
oppossum
(Monodelphis domestica)
Mammalia MTF1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTF1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTF1 35
  • 78.44 (n)
  • 80.33 (a)
MTF1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTF1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtf1 35
  • 64.77 (n)
  • 64.01 (a)
zebrafish
(Danio rerio)
Actinopterygii mtf1 35
  • 63.07 (n)
  • 62.43 (a)
mtf1 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.308 35
fruit fly
(Drosophila melanogaster)
Insecta MTF-1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for MTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTF1 Gene

ENSEMBL:
Gene Tree for MTF1 (if available)
TreeFam:
Gene Tree for MTF1 (if available)

Paralogs for MTF1 Gene

genes like me logo Genes that share paralogs with MTF1: view

Variants for MTF1 Gene

Sequence variations from dbSNP and Humsavar for MTF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs473186 -- 37,810,709(-) CAGAA(A/G)GATTT utr-variant-3-prime
rs900679 -- 37,825,816(-) aaaaa(A/T)aaaat intron-variant
rs766588 -- 37,833,168(-) CCAAG(A/G)TTTAT intron-variant
rs2361033 -- 37,842,266(+) TAATA(A/C)CAATA intron-variant
rs3748682 -- 37,814,315(+) AGCGA(C/T)GTTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTF1 Gene

Variant ID Type Subtype PubMed ID
nsv871810 CNV Loss 21882294
nsv870730 CNV Gain 21882294
nsv510 CNV Insertion 18451855
nsv506927 CNV Insertion 20534489

Variation tolerance for MTF1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTF1 Gene

HapMap Linkage Disequilibrium report
MTF1
Human Gene Mutation Database (HGMD)
MTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTF1 Gene

Disorders for MTF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MTF1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
enamel erosion
dentine erosion
tooth erosion
  • generalized erosion
- elite association - COSMIC cancer census association via MalaCards
Search MTF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTF1

Genetic Association Database (GAD)
MTF1
Human Genome Epidemiology (HuGE) Navigator
MTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTF1
genes like me logo Genes that share disorders with MTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTF1 Gene

Publications for MTF1 Gene

  1. Cloning, chromosomal mapping and characterization of the human metal- regulatory transcription factor MTF-1. (PMID: 8065932) Brugnera E. … Schaffner W. (Nucleic Acids Res. 1994) 2 3 4 23 67
  2. Metal transcription factor-1 regulation via MREs in the transcribed regions of selenoprotein H and other metal-responsive genes. (PMID: 19913599) Stoytcheva Z.R. … Berry M.J. (Biochim. Biophys. Acta 2010) 3 23
  3. Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. (PMID: 19956853) Takamura M. … Aoyagi Y. (Int. J. Oncol. 2010) 3 23
  4. Divalent metal-dependent regulation of hepcidin expression by MTF-1. (PMID: 20026331) Balesaria S. … Srai S.K. (FEBS Lett. 2010) 3 23
  5. Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1. (PMID: 18990686) Bellingham S.A. … Hill A.F. (J. Biol. Chem. 2009) 3 23

Products for MTF1 Gene

Sources for MTF1 Gene

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