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Aliases for MTF1 Gene

Aliases for MTF1 Gene

  • Metal Regulatory Transcription Factor 1 2 3 5
  • MRE-Binding Transcription Factor 3 4
  • Transcription Factor MTF-1 3 4
  • Metal-Responsive Transcription Factor 1 3
  • MRE-Binding Transcription Factor-1 3
  • Zinc Regulatory Factor 3
  • MTF-1 3
  • ZRF 3

External Ids for MTF1 Gene

Previous GeneCards Identifiers for MTF1 Gene

  • GC01M038114
  • GC01M037334
  • GC01M037706
  • GC01M9V0006
  • GC01M037948
  • GC01M038047
  • GC01M038275
  • GC01M036393

Summaries for MTF1 Gene

Entrez Gene Summary for MTF1 Gene

  • This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

GeneCards Summary for MTF1 Gene

MTF1 (Metal Regulatory Transcription Factor 1) is a Protein Coding gene. Diseases associated with MTF1 include Enamel Erosion and Dentine Erosion. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF143.

UniProtKB/Swiss-Prot for MTF1 Gene

  • Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Gene Wiki entry for MTF1 Gene

Additional gene information for MTF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTF1 Gene

Genomics for MTF1 Gene

Regulatory Elements for MTF1 Gene

Enhancers for MTF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H037850 1.6 FANTOM5 Ensembl ENCODE dbSUPER 45.7 +7.7 7724 3 SOX6 HLF CEBPB CEBPG ZNF316 GATA2 ZNF366 NR2C1 HMBOX1 ZNF24 MTF1 INPP5B ZC3H12A YRDC C1orf122 ENSG00000233728 SNIP1 RPS2P13
GH01H037470 2.1 FANTOM5 Ensembl ENCODE dbSUPER 33.9 +380.3 380261 18 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZC3H12A LINC01137 MTF1 SNIP1 GNL2 DNALI1 SF3A3 FTH1P1 MEAF6 YRDC
GH01H037845 1.2 FANTOM5 Ensembl 29.8 +13.2 13224 2 PKNOX1 IRF2 ZNF316 GATA2 STAT2 TRIM24 NFE2 IKZF2 MTA2 CEBPB MTF1 ZC3H12A YRDC C1orf122 ENSG00000233728 CDCA8 C1orf109 FHL3 SNIP1 RPS2P13
GH01H037825 0.7 FANTOM5 Ensembl 37.7 +34.0 34024 0 EGR1 MTF1 INPP5B ZC3H12A ENSG00000230955 ENSG00000233728 SNIP1 YRDC PIR39326 GC01M037827 RPS2P13
GH01H038008 1.7 Ensembl ENCODE dbSUPER 10.2 -153.3 -153286 9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 SF3A3 C1orf109 INPP5B SNIP1 RNU6-510P RSPO1 ENSG00000230955 MTF1 YRDC C1orf122
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTF1 on UCSC Golden Path with GeneCards custom track

Promoters for MTF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004901 124 1801 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for MTF1 Gene

Chromosome:
1
Start:
37,809,567 bp from pter
End:
37,859,624 bp from pter
Size:
50,058 bases
Orientation:
Minus strand

Genomic View for MTF1 Gene

Genes around MTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTF1 Gene

Proteins for MTF1 Gene

  • Protein details for MTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14872-MTF1_HUMAN
    Recommended name:
    Metal regulatory transcription factor 1
    Protein Accession:
    Q14872
    Secondary Accessions:
    • B2RAK6
    • Q96CB1

    Protein attributes for MTF1 Gene

    Size:
    753 amino acids
    Molecular mass:
    80957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTF1 Gene

Post-translational modifications for MTF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTF1 Gene

Antibody Products

  • Abcam antibodies for MTF1

No data available for DME Specific Peptides for MTF1 Gene

Domains & Families for MTF1 Gene

Gene Families for MTF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MTF1 Gene

Suggested Antigen Peptide Sequences for MTF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MTF1: view

No data available for UniProtKB/Swiss-Prot for MTF1 Gene

Function for MTF1 Gene

Molecular function for MTF1 Gene

GENATLAS Biochemistry:
metal-regulatory transcription factor MTF-1
UniProtKB/Swiss-Prot Function:
Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Phenotypes From GWAS Catalog for MTF1 Gene

Gene Ontology (GO) - Molecular Function for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9582278
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001047 core promoter binding IDA 15735762
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9582278
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with MTF1: view
genes like me logo Genes that share phenotypes with MTF1: view

Animal Models for MTF1 Gene

MGI Knock Outs for MTF1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTF1 Gene

Localization for MTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTF1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 3208749
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MTF1: view

Pathways & Interactions for MTF1 Gene

genes like me logo Genes that share pathways with MTF1: view

Gene Ontology (GO) - Biological Process for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 3208749
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006979 response to oxidative stress IEA --
genes like me logo Genes that share ontologies with MTF1: view

No data available for SIGNOR curated interactions for MTF1 Gene

Drugs & Compounds for MTF1 Gene

(9) Drugs for MTF1 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma Carrier, binder 188
LOR-253 Pharma 0

(5) Additional Compounds for MTF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MTF1: view

Transcripts for MTF1 Gene

Unigene Clusters for MTF1 Gene

Metal-regulatory transcription factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MTF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for MTF1 Gene

GeneLoc Exon Structure for
MTF1
ECgene alternative splicing isoforms for
MTF1

Expression for MTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTF1 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for MTF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.7) and Placenta (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTF1 Gene



Protein tissue co-expression partners for MTF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTF1 Gene:

MTF1

SOURCE GeneReport for Unigene cluster for MTF1 Gene:

Hs.471991

Evidence on tissue expression from TISSUES for MTF1 Gene

  • Liver(4.3)
  • Muscle(4.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with MTF1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTF1 Gene

Orthologs for MTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTF1 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia MTF1 33 34
  • 93.83 (n)
cow
(Bos Taurus)
Mammalia MTF1 33 34
  • 91.83 (n)
rat
(Rattus norvegicus)
Mammalia Mtf1 33
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Mtf1 33 16 34
  • 91.23 (n)
oppossum
(Monodelphis domestica)
Mammalia MTF1 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTF1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTF1 33 34
  • 78.44 (n)
lizard
(Anolis carolinensis)
Reptilia MTF1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtf1 33
  • 64.77 (n)
zebrafish
(Danio rerio)
Actinopterygii mtf1 33 34
  • 63.07 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.308 33
fruit fly
(Drosophila melanogaster)
Insecta MTF-1 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 64 (a)
OneToOne
Species where no ortholog for MTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTF1 Gene

ENSEMBL:
Gene Tree for MTF1 (if available)
TreeFam:
Gene Tree for MTF1 (if available)

Paralogs for MTF1 Gene

Paralogs for MTF1 Gene

genes like me logo Genes that share paralogs with MTF1: view

Variants for MTF1 Gene

Sequence variations from dbSNP and Humsavar for MTF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000023763 -- 37,859,321(+) GGGGT(C/T)TCCAA intron-variant, upstream-variant-2KB
rs1000077481 -- 37,837,598(+) CCTCT(C/T)TGGTT intron-variant
rs1000091003 -- 37,852,640(+) TTTTT(-/C)TTTTT intron-variant
rs1000096267 -- 37,820,944(+) GAGAC(A/G)GAGGC intron-variant
rs1000145812 -- 37,810,872(+) CTTAA(G/T)GAACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTF1 Gene

Variant ID Type Subtype PubMed ID
nsv506927 OTHER sequence alteration 20534489
nsv510 CNV insertion 18451855
nsv945884 CNV duplication 23825009

Variation tolerance for MTF1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTF1 Gene

Human Gene Mutation Database (HGMD)
MTF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTF1 Gene

Disorders for MTF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MTF1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
enamel erosion
dentine erosion
tooth erosion
  • generalized erosion
- elite association - COSMIC cancer census association via MalaCards
Search MTF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTF1

Genetic Association Database (GAD)
MTF1
Human Genome Epidemiology (HuGE) Navigator
MTF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTF1
genes like me logo Genes that share disorders with MTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTF1 Gene

Publications for MTF1 Gene

  1. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. (PMID: 8065932) Brugnera E … Schaffner W (Nucleic acids research 1994) 2 3 4 22 60
  2. Genetic susceptibility to environmental toxicants in ALS. (PMID: 17503480) Morahan JM … Pamphlett R (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 45 60
  3. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N … Do CB (PloS one 2012) 3 45 60
  4. Divalent metal-dependent regulation of hepcidin expression by MTF-1. (PMID: 20026331) Balesaria S … Srai SK (FEBS letters 2010) 3 22 60
  5. Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. (PMID: 19956853) Takamura M … Aoyagi Y (International journal of oncology 2010) 3 22 60

Products for MTF1 Gene

Sources for MTF1 Gene

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