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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTF1 Gene

protein-coding   GIFtS: 52
GCID: GC01M038275

metal-regulatory transcription factor 1
 Explore 18 diseases affiliated with
MTF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MTF1    

Aliases
for MTF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metal-Regulatory Transcription Factor 11 2     Metal Regulatory Transcription Factor 12
Transcription Factor MTF-12 3     Metal-Responsive Transcription Factor 12
MRE-Binding Transcription Factor2 3     MRE-Binding Transcription Factor-12
MTF-12     Zinc Regulatory Factor2
ZRF2     

External Ids:    HGNC: 74281   Entrez Gene: 45202   Ensembl: ENSG000001887867   OMIM: 6001725   UniProtKB: Q148723   

Export aliases for MTF1 gene to outside databases

Previous GC identifers: GC01M038114 GC01M037334 GC01M037706 GC01M9V0006 GC01M037948 GC01M038047 GC01M036393


Summaries
for MTF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MTF1:
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal
homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic
shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a
metal-responsive element (MRE). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872
Function: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)

Gene Wiki entry for MTF1


Genomic Views
for MTF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTF1 gene promoter:
         p53   AP-1   AP-2alpha isoform 3   AP-2alpha isoform 2   CREB   deltaCREB   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MTF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p33

MTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M038275:  view genomic region     (about GC identifiers)

Start:
 38,275,239 bp from pter      End:
 38,325,292 bp from pter
Size:
 50,054 bases      Orientation:
 minus strand

Proteins
for MTF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872 (See protein sequence)
Recommended Name: Metal regulatory transcription factor 1  
Size: 753 amino acids; 80957 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B2RAK6 Q96CB1

Explore the universe of human proteins at neXtProt for MTF1: NX_Q14872

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14872

    • MTF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005946.2  
    ENSEMBL proteins: 
     ENSP00000362127  

    Human Recombinant Protein Products: 
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    Novus Biologicals MTF1 Protein
    Novus Biologicals MTF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTF1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    MTF1 for ontologies           About GeneDecksing



    MTF1 Antibody Products: 
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    Novus Biologicals MTF1 Antibodies
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    Uscn Antibodies for MTF1
    Search ThermoFisher Antibodies for MTF1

    Assay Products for MTF1: 
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    Uscn ELISAs and CLIAs for MTF1

    Protein Domains /
    Families
    for MTF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MTF1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q14872

    ProtoNet protein and cluster: Q14872

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872
    Similarity: Contains 6 C2H2-type zinc fingers


    Function
    for MTF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MTF1_HUMAN, Q14872
    Function: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)

         Genatlas biochemistry entry for MTF1:
    metal-regulatory transcription factor MTF-1

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTF1
    8/205 QIAGEN miScript miRNA Assays for microRNAs that regulate MTF1 (see all 205):
    hsa-miR-194* hsa-miR-579 hsa-miR-100* hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTF1 (see all 7)
    OriGene shRNA RFP: MTF1
    OriGene siRNA: MTF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTF1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MTF1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTF1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTF1
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    GenScript: all cDNA clones in your preferred vector: MTF1 (NM_005955)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF1 

    Cell Line
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    Search LifeMap BioReagents cell lines for MTF1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0001047core promoter binding IDA15735762
    GO:0003677DNA binding TAS8065932
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS3208749


    MTF1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mtf1tm1Wsc for MTF1
         9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mtf1):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  normal  tumorigenesis 

    MTF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MTF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTF1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for MTF1 (Q148721, 2, 3 ENSP000003621274) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1M1Q9BXS51, 2, 3, ENSP000003889964EBI-747024,EBI-541426 MINT-66977 I2D: score=4 STRING: ENSP00000388996
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    CERS2Q96G233I2D: score=1 
    NR4A3Q925703I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS3208749
    GO:0006979response to oxidative stress IEA--
    GO:0010038response to metal ion TAS8065932
    GO:0045893positive regulation of transcription, DNA-dependent ----


    MTF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MTF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTF1
    10/13 Novoseek chemical compound relationships for MTF1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 77.5 119 17462582 (5), 14612393 (4), 10026134 (4), 8467794 (3) (see all 44)
    cadmium 67.5 23 10026134 (3), 19040355 (2), 19913599 (1), 11266553 (1) (see all 9)
    gamma-glutamylcysteine 58 4 11266553 (1), 15378601 (1), 18057785 (1)
    copper 57 37 15833915 (3), 19040355 (3), 11266553 (1), 20038716 (1) (see all 10)
    mercury 33.2 7 19040355 (2)
    cysteine 23.6 5 14610091 (2), 17409697 (1), 11735399 (1)
    h2o2 10.8 3 14612393 (2), 11306562 (1)
    cycloheximide 7.75 6 16615093 (2), 11306562 (1)
    proline 6.45 1 8467794 (1)
    oxygen 0 1 15544971 (1)

    Search CenterWatch for drugs/clinical trials and news about MTF1 

    Transcripts
    for MTF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MTF1 gene: 
    NM_005955.2  

    Unigene Cluster for MTF1:

    Metal-regulatory transcription factor 1
    Hs.471991  [show with all ESTs]
    Unigene Representative Sequence: NM_005955
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373036(uc001cce.1 uc009vvj.1) ENST00000468190

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTF1
    8/205 QIAGEN miScript miRNA Assays for microRNAs that regulate MTF1 (see all 205):
    hsa-miR-194* hsa-miR-579 hsa-miR-100* hsa-miR-520f hsa-miR-1914* hsa-miR-106a hsa-miR-519a hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTF1 (see all 7)
    OriGene shRNA RFP: MTF1
    OriGene siRNA: MTF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTF1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTF1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTF1 (NM_005955)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTF1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTF1

    Additional cDNA sequence: 

    AK125603.1 AK225923.1 AK298751.1 AK309584.1 AK314233.1 BC014454.1 X78710.1 

    6 DOTS entries:

    DT.441267  DT.101964233  DT.97770405  DT.91788107  DT.99969770  DT.87046565 

    24/68 AceView cDNA sequences (see all 68):

    AI468051 X78710 AI016516 AW057659 BI257931 AI125324 BX097718 BC014454 
    CA309684 NM_005955 AA743786 BE906486 BQ425250 AA252540 BP342212 CA748631 
    AI078549 AW057658 BQ221975 AI024663 AA448256 AI803055 BF508263 BF108692 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13
    SP1:              -                                                                       -               
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                      -               
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MTF1

    Expression
    for MTF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAACAACGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MTF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudHepatoblastsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MTF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTF1

    SOURCE GeneReport for Unigene cluster: Hs.471991
        SABiosciences Custom PCR Arrays for MTF1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTF1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTF1

    Orthologs
    for MTF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MTF1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MTF11 metal-regulatory transcription factor 1 78.94(n)
    80.97(a)    		   428218  NM_001031495.1  NP_001026666.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MTF16
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343426.1(569511-575698)
    zebrafish
    (Danio rerio)    		 Actinopterygii mtf12 metal-regulatory transcription factor 1 79.51(n)   195821  AF458116.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MTF-16
    		 Metal response element-binding Transcription Facto...
    		 20(a)
    		 1 ↔ 1
    		 3L(9423412-9431811)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G066346
    		 uncharacterized zinc finger protein
    		 14(a)
    		 1 → many
    		 4(3764289-3766578)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ZOS5-01 - C2H2 zinc finger protein, expressed
    		 17(a)
    14(a)
    		 many ↔ many
    many ↔ many
    		 2(20795085-20798606)
    5(321102-324421)


    ENSEMBL Gene Tree for MTF1 (if available)
    TreeFam Gene Tree for MTF1 (if available) 

    Paralogs
    for MTF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTF1 gene
    YY22  ZIC32  ZNF4102  ZNF762  GLI12  ZIC22  YY12  ZIC12  
    GLIS22  GLI22  ZIC42  GLIS12  ZFP422  ZNF1432  GLIS32  ZIC52  
    GLI32  

    MTF1 for paralogs           About GeneDecksing



    Genomic Variants
    for MTF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/736 NCBI SNPs in MTF1 are shown (see all 736)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2003052761,2
    		--38274754(+) TCCCCA/GAGCAG 4 -- ds5001 us2k1 ut310--------
    rs1826861031,2
    		C,--38274765(+) AATACC/TCTGAC 4 -- ds5001 us2k1 ut310--------
    rs773801461,2
    		C,--38274880(+) GGCAGC/GTCTGC 4 -- ut31 us2k1 ds50010--------
    rs1879723441,2
    		--38275062(+) TTTTGG/TGGGCT 4 -- ds5001 us2k1 ut310--------
    rs10465201,2
    		C--38275077(+) GCCCCA/CCAAAA 4 -- ut31 us2k1 ds50011Minor allele frequency- C:0.00NA 2
    rs38062861,2
    		C,F,--38275277(+) CATTAG/CTATTT 4 -- ut31 us2k1 int11Minor allele frequency- C:0.02EA 120
    rs1506267711,2
    		--38275321(+) TTCACG/TTTTTA 4 -- int1 ut31 us2k10--------
    rs1396670311,2
    		--38275625(+) GGCTCC/TTGCCT 4 -- ut31 us2k1 int10--------
    rs1508391001,2
    		--38275672(+) AAATC-/TGTTTCC 2 -- ut31 us2k10--------
    rs1931591461,2
    		--38275767(+) TCTCCA/GAAACA 2 -- ut31 us2k10--------

    HapMap Linkage Disequilibrium report for MTF1 (38275239 - 38325292 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MTF1: --

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    Disorders / Diseases
    for MTF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MTF1 for disorders           About GeneDecksing

    OMIM gene information: 600172    OMIM disorders: --

    18 diseases for MTF1:    About MalaCards
    enamel erosion    dentine erosion    autism spectrum disorder    menkes disease
    papillary thyroid carcinoma    lymphosarcoma    thyroid carcinoma    cervical carcinoma
    thyroiditis    thrombosis    hepatocellular carcinoma    cervicitis
    carcinoma    cholangiocarcinoma    breast cancer    hypoxia
    neuroblastoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for MTF1:
    Enamel erosion     Dentine erosion

    3 Novoseek disease relationships for MTF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 15.6 4 11266553 (1), 11306562 (1), 18593933 (1), 12805380 (1)
    tumors 0 4 20087061 (1), 19956853 (1)
    lymphoma 0 4 15516976 (2), 17308060 (1)

    Human Genome Epidemiology (HuGE) Navigator: MTF1 (5 documents)

    Export disorders for MTF1 gene to outside databases

    Publications
    for MTF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTF1 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with MTF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping and characterization of the human metal- regulatory transcription factor MTF-1. (PubMed id 8065932)1, 2, 3, 9 Brugnera E.... Schaffner W. (1994)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Metal-responsive transcription factor 1 (MTF-1) activ ity is regulated by a nonconventional nuclear localization signal and a metal-r esponsive transactivation domain. (PubMed id 19797083)1, 9 Lindert U....Schaffner W. (2009)
    6. Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. (PubMed id 11306562)1, 9 Saydam N....Schaffner W. (2001)
    7. Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. (PubMed id 15318808)1, 9 Balamurugan K....Schaffner W. (2004)
    8. Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells. (PubMed id 19022893)1, 9 Nishimoto F....Kimura T. (2009)
    9. Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. (PubMed id 12716893)1, 9 Majumder S....Jacob S.T. (2003)
    10. Metal transcription factor-1 regulation via MREs in t he transcribed regions of selenoprotein H and other metal-responsive genes. (PubMed id 19913599)1, 9 Stoytcheva Z.R....Berry M.J. (2010)

    External Searches for MTF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MTF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4520 HGNC: 7428 AceView: MTF1 Ensembl:ENSG00000188786 euGenes: HUgn4520
    ECgene: MTF1 H-InvDB: MTF1

    Other Databases showing MTF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MTF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTF1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MTF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MTF1 gene:
    Search GeneIP for patents involving MTF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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