MTERFD3 Gene
protein-coding GIFtS: 43
GCID: GC12M107371
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|
MTERF domain containing 3
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Aliases
for MTERFD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MTERF Domain Containing 31 2 | | MTERFL1 | | Mitochondrial Transcription Termination Factor 22 3 | | FLJ140621 | | Mitochondrial Transcription Termination Factor-Like Protein2 3 | | MTERF Domain-Containing Protein 3, Mitochondrial2 | | MTERF21 | | |
Export aliases for MTERFD3 gene to outside databasesPrevious GC identifers: GC12M105874 GC12M104431 |
Summaries
for MTERFD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MTER3_HUMAN, Q49AM1Function: Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription,both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes andnormal mitochondrial function (By similarity)
|
Genomic Views
for MTERFD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTERFD3 gene promoter:
p53 STAT4 NF-YA MIF-1 NF-YB CBF-A CBF-B CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTERFD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTERFD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.1 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q24.1MTERFD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M107371: view genomic region
(about GC identifiers)
Start:
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107,371,069 bp from pter |
End:
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107,380,944 bp from pter |
Size:
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9,876 bases |
Orientation:
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minus strand |
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Proteins
for MTERFD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTER3_HUMAN, Q49AM1 (See
protein sequence)Recommended Name: mTERF domain-containing protein 3, mitochondrial precursor Size: 385 amino acids; 44414 Da
Subunit: Monomer. Homodimer (By similarity)
Subcellular location: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid (By similarity)
Secondary accessions: Q53HM2 Q9H4L6 Q9H7Y9Explore the universe of human proteins at neXtProt for MTERFD3: NX_Q49AM1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q49AM1
MTERFD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001028222.1 NP_079474.2
ENSEMBL proteins: ENSP00000376575 ENSP00000240050 ENSP00000447651 ENSP00000448343 ENSP00000448854 ENSP00000448246
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MTERFD3 for ontologies About GeneDecksing
MTERFD3 Antibody Products:
Assay Products for MTERFD3: |
Protein
Domains /
Families
for MTERFD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTERFD3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q49AM1ProtoNet protein and cluster: Q49AM1 UniProtKB/Swiss-Prot: MTER3_HUMAN, Q49AM1Similarity: Belongs to the mTERF family |
Function
for MTERFD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MTER3_HUMAN, Q49AM1Function: Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription,both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes andnormal mitochondrial function (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTERFD3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTERFD3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MTERFD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTERFD3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTERFD3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042803 | protein homodimerization activity |
IEA | -- | | GO:0044212 | transcription regulatory region DNA binding |
ISS | -- |
MTERFD3 for ontologies About GeneDecksing
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mterfd3):
MTERFD3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MTERFD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTERFD3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
ISS | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
ISS | -- |
MTERFD3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTERFD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MTERFD3
Search CenterWatch for drugs/clinical trials and news about MTERFD3 / MTER3
|
Transcripts
for MTERFD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTERFD3 gene (2 alternative transcripts): NM_001033050.2 NM_025198.4 Unigene Cluster for MTERFD3: MTERF domain containing 3 Hs.5009 [show with all ESTs]Unigene Representative Sequence: BC0503617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392830(uc001tmh.1) ENST00000240050(uc001tmf.1 uc001tmg.1)
ENST00000552029(uc001tme.1) ENST00000548101 ENST00000550736 ENST00000550496
ENST00000547115
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTERFD3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTERFD3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MTERFD3 (NM_025198) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTERFD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTERFD3 |
Additional cDNA sequence: AK024124.1 AK222558.1 AL832827.1 AY008301.1 BC008486.1 BC025984.1 BC036066.1 BC050361.1 BC068468.1 8 DOTS entries: DT.440857 DT.97784502 DT.100782463 DT.100782465 DT.97794020 DT.121190729 DT.86848655 DT.91910979 24/124 AceView cDNA sequences (see all 124): CA419710 BX280808 BF434578 AI167895 AI082605 BM717116 AI288331 BE674211 AK024124 AL832827 BU738437 BF509531 CB268445 BF512961 AI694029 C01702 CD364391 AI796550 BU631190 AI420599 AA682312 AW085154 AU120486 AW614918
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MTERFD3 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e |
|---|
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| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MTERFD3
|
Expression
for MTERFD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTERFD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTGAAGCA
About this image
See MTERFD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTERFD3
SOURCE GeneReport for Unigene cluster: Hs.5009
UniProtKB/Swiss-Prot: MTER3_HUMAN, Q49AM1Tissue specificity: Expressed in skeletal muscle, heart, liver and pancreas
SABiosciences Custom PCR Arrays for MTERFD3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTERFD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTERFD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTERFD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTERFD3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTERFD3 |
Orthologs
for MTERFD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MTERFD3 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for MTERFD3 (if available)
TreeFam Gene Tree for MTERFD3 (if available) |
Paralogs
for MTERFD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTERFD3 gene
- MTERF2
1 SIMAP similar gene for MTERFD3 using alignment to 4 protein entries: MTER3_HUMAN (see all proteins):MTERF
MTERFD3 for paralogs About GeneDecksing
|
Genomic Variants
for MTERFD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTERFD3 (107371069 - 107380944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MTERFD3
1 CNV: 1507 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTERFD3 |
|
Disorders
/ Diseases
for MTERFD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MTERFD3 for disorders About MalaCards
MTERFD3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: MTERFD3 (1 document)
Export disorders for MTERFD3 gene to outside databases
|
Publications
for MTERFD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTERFD3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MTERFD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. (PubMed id 16226716)1, 2, 9 Chen Y....Tan D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Overexpression of MTERFD1 or MTERFD3 impairs the comp letion of mitochondrial DNA replication. (PubMed id 20577816)1 HyvAorinen A.K....Jacobs H.T. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain. (PubMed id 20430012)1 SpAYhr H....Gustafsson C.M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
|
External Searches for MTERFD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTERFD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTERFD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTERFD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MTERFD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MTERFD3 gene:
Search GeneIP for patents involving MTERFD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTERFD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTERFD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTERFD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTERFD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTERFD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTERFD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTERFD3 |
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 | | | MTERFD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTERFD3 |
|  |  |  | | | | Search ThermoFisher Antibodies for MTERFD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTERFD3 |
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