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Aliases for MTERF4 Gene

Aliases for MTERF4 Gene

  • Mitochondrial Transcription Termination Factor 4 2 3 4 5
  • MTERF Domain-Containing Protein 2 3 4
  • MTERF Domain Containing 2 2 3
  • MTERFD2 3 4

External Ids for MTERF4 Gene

Previous HGNC Symbols for MTERF4 Gene

  • MTERFD2

Summaries for MTERF4 Gene

GeneCards Summary for MTERF4 Gene

MTERF4 (Mitochondrial Transcription Termination Factor 4) is a Protein Coding gene. GO annotations related to this gene include double-stranded DNA binding and rRNA binding.

UniProtKB/Swiss-Prot for MTERF4 Gene

  • Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF4 Gene

Genomics for MTERF4 Gene

Regulatory Elements for MTERF4 Gene

Enhancers for MTERF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTERF4 on UCSC Golden Path with GeneCards custom track

Promoters for MTERF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTERF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTERF4 Gene

Chromosome:
2
Start:
241,072,169 bp from pter
End:
241,102,359 bp from pter
Size:
30,191 bases
Orientation:
Minus strand

Genomic View for MTERF4 Gene

Genes around MTERF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTERF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTERF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF4 Gene

Proteins for MTERF4 Gene

  • Protein details for MTERF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    NP_872307.2
    Recommended name:
    Protein Accession:
    NP_872307.2

    Protein attributes for MTERF4 Gene

    Size:
    amino acids
    Molecular mass:
    Da
    Quaternary structure:
    No Data Available
  • Protein details for MTERF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6M4-MTEF4_HUMAN
    Recommended name:
    Transcription termination factor 4, mitochondrial
    Protein Accession:
    Q7Z6M4
    Secondary Accessions:
    • A8K6K0
    • Q9P0E0

    Protein attributes for MTERF4 Gene

    Size:
    381 amino acids
    Molecular mass:
    43958 Da
    Quaternary structure:
    • Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.
    SequenceCaution:
    • Sequence=AAF28919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MTERF4 Gene

neXtProt entry for MTERF4 Gene

Proteomics data for MTERF4 Gene at MOPED

Post-translational modifications for MTERF4 Gene

  • The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.
  • Ubiquitination at Lys 168
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTERF4 Gene

Domains & Families for MTERF4 Gene

Protein Domains for MTERF4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z6M4

UniProtKB/Swiss-Prot:

MTEF4_HUMAN :
  • The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.
  • Belongs to the mTERF family.
Domain:
  • The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction.
Family:
  • Belongs to the mTERF family.
genes like me logo Genes that share domains with MTERF4: view

No data available for Gene Families for MTERF4 Gene

Function for MTERF4 Gene

Molecular function for MTERF4 Gene

UniProtKB/Swiss-Prot Function:
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
genes like me logo Genes that share phenotypes with MTERF4: view

Animal Models for MTERF4 Gene

MGI Knock Outs for MTERF4:

Animal Model Products

miRNA for MTERF4 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTERF4 Gene

Localization for MTERF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF4 Gene

Mitochondrion.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MTERF4 Gene

Pathways & Interactions for MTERF4 Gene

SuperPathways for MTERF4 Gene

No Data Available

Interacting Proteins for MTERF4 Gene

Gene Ontology (GO) - Biological Process for MTERF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with MTERF4: view

No data available for Pathways by source and SIGNOR curated interactions for MTERF4 Gene

Drugs & Compounds for MTERF4 Gene

No Compound Related Data Available

Transcripts for MTERF4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - -
SP11: -

Relevant External Links for MTERF4 Gene

GeneLoc Exon Structure for
MTERF4
ECgene alternative splicing isoforms for
MTERF4

Expression for MTERF4 Gene

mRNA expression in normal human tissues for MTERF4 Gene

Protein differential expression in normal tissues from HIPED for MTERF4 Gene

This gene is overexpressed in Lung (46.4) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTERF4 Gene



genes like me logo Genes that share expression patterns with MTERF4: view

Protein tissue co-expression partners for MTERF4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTERF4 Gene

Orthologs for MTERF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTERF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTERFD2 35
  • 81.75 (n)
  • 74.62 (a)
MTERFD2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTERFD2 35
  • 75.73 (n)
  • 69.3 (a)
mouse
(Mus musculus)
Mammalia Mterfd2 35
  • 77.08 (n)
  • 66.56 (a)
Mterf4 16
Mterfd2 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTERFD2 35
  • 99.02 (n)
  • 97.64 (a)
MTERFD2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mterfd2 35
  • 78.01 (n)
  • 66.57 (a)
oppossum
(Monodelphis domestica)
Mammalia MTERFD2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTERFD2 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTERFD2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mterfd2 35
  • 50.81 (n)
  • 39.21 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-94h10.5 35
  • 52.19 (n)
  • 43.86 (a)
MTERFD2 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K11D2.5 36
  • 22 (a)
OneToOne
Species with no ortholog for MTERF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTERF4 Gene

ENSEMBL:
Gene Tree for MTERF4 (if available)
TreeFam:
Gene Tree for MTERF4 (if available)

Paralogs for MTERF4 Gene

No data available for Paralogs for MTERF4 Gene

Variants for MTERF4 Gene

Sequence variations from dbSNP and Humsavar for MTERF4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3796093 - 241,099,783(+) GGCTG(C/T)AGTCA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs2286323 - 241,097,382(+) GGCGC(A/G)TGGTG intron-variant, nc-transcript-variant, reference, missense
rs2240539 - 241,096,129(+) ATCCA(C/G)ACTTG intron-variant, nc-transcript-variant, reference, missense
rs10203977 - 241,096,103(+) tcctc(A/C)tcatc intron-variant, nc-transcript-variant, reference, missense
rs10167328 - 241,096,010(+) TCCtc(A/C/G)tcgtc intron-variant, nc-transcript-variant, reference, synonymous-codon, missense

Variation tolerance for MTERF4 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MTERF4 Gene

Disorders for MTERF4 Gene

Relevant External Links for MTERF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTERF4

No disorders were found for MTERF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTERF4 Gene

Publications for MTERF4 Gene

  1. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. (PMID: 21531335) Camara Y. … Larsson N.G. (Cell Metab. 2011) 2 3 4 67
  2. A family of putative transcription termination factors shared amongst metazoans and plants. (PMID: 16193327) Linder T. … Gustafsson C.M. (Curr. Genet. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. (PMID: 22675492) Prescott J. … De Vivo I. (PLoS ONE 2012) 3

Products for MTERF4 Gene

Sources for MTERF4 Gene

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