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Aliases for MTERF4 Gene

Aliases for MTERF4 Gene

  • Mitochondrial Transcription Termination Factor 4 2 3 4
  • MTERF Domain-Containing Protein 2 3 4
  • MTERF Domain Containing 2 2 3
  • MTERFD2 3 4
  • Transcription Termination Factor 4, Mitochondrial 3
  • MTERFD2, 6

External Ids for MTERF4 Gene

Previous HGNC Symbols for MTERF4 Gene

  • MTERFD2

Summaries for MTERF4 Gene

GeneCards Summary for MTERF4 Gene

MTERF4 (Mitochondrial Transcription Termination Factor 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTERF4 Gene

  • Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF4 Gene

Genomics for MTERF4 Gene

Genomic Location for MTERF4 Gene

Start:
241,072,168 bp from pter
End:
241,102,332 bp from pter
Size:
30,165 bases
Orientation:
Minus strand

Genomic View for MTERF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTERF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF4 Gene

No data available for Regulatory Elements for MTERF4 Gene

Proteins for MTERF4 Gene

  • Protein details for MTERF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    NP_872307.2
    Recommended name:
    Protein Accession:
    NP_872307.2
    Secondary Accessions:

    Protein attributes for MTERF4 Gene

    Size:
    amino acids
    Molecular mass:
    Da
    Quaternary structure:
    No Data Available
  • Protein details for MTERF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6M4-MTEF4_HUMAN
    Recommended name:
    Transcription termination factor 4, mitochondrial
    Protein Accession:
    Q7Z6M4
    Secondary Accessions:
    • A8K6K0
    • Q9P0E0

    Protein attributes for MTERF4 Gene

    Size:
    381 amino acids
    Molecular mass:
    43958 Da
    Quaternary structure:
    • Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.
    SequenceCaution:
    • Sequence=AAF28919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MTERF4 Gene

neXtProt entry for MTERF4 Gene

Proteomics data for MTERF4 Gene at MOPED

Post-translational modifications for MTERF4 Gene

  • The mature mitochondrial protein exists in 2 forms differing at the level of their N-terminus, one is starting at residue 43 and the other at residue 48.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTERF4 Gene

Domains for MTERF4 Gene

Protein Domains for MTERF4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z6M4

UniProtKB/Swiss-Prot:

MTEF4_HUMAN :
  • Q7Z6M4
Domain:
  • The MTERF repeats form a half-donut shaped, right-handed superhelix, where the concave side displays a positively charged path for nucleic acid interaction
Family:
  • Belongs to the mTERF family.
genes like me logo Genes that share domains with MTERF4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MTERF4 Gene

Function for MTERF4 Gene

Molecular function for MTERF4 Gene

UniProtKB/Swiss-Prot Function: Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).

Gene Ontology (GO) - Molecular Function for MTERF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0005515 protein binding IPI 21531335
GO:0019843 rRNA binding IDA 21531335
genes like me logo Genes that share ontologies with MTERF4: view
genes like me logo Genes that share phenotypes with MTERF4: view

Animal Models for MTERF4 Gene

MGI Knock Outs for MTERF4:

miRNA for MTERF4 Gene

miRTarBase miRNAs that target MTERF4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTERF4 Gene

Localization for MTERF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF4 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for MTERF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005762 mitochondrial large ribosomal subunit IDA 21531335
genes like me logo Genes that share ontologies with MTERF4: view

No data available for Subcellular locations from COMPARTMENTS for MTERF4 Gene

Pathways for MTERF4 Gene

SuperPathways for MTERF4 Gene

No Data Available

Interacting Proteins for MTERF4 Gene

Gene Ontology (GO) - Biological Process for MTERF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing IEA --
GO:0006390 transcription from mitochondrial promoter IEA --
GO:0006626 protein targeting to mitochondrion IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with MTERF4: view

No data available for Pathways by source for MTERF4 Gene

Transcripts for MTERF4 Gene

mRNA/cDNA for MTERF4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTERF4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MTERF4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - -
SP11: -

Relevant External Links for MTERF4 Gene

GeneLoc Exon Structure for
MTERF4
ECgene alternative splicing isoforms for
MTERF4

Expression for MTERF4 Gene

mRNA expression in normal human tissues for MTERF4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTERF4 Gene

genes like me logo Genes that share expressions with MTERF4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTERF4 Gene

Orthologs for MTERF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTERF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTERFD2 35
  • 99.02 (n)
  • 97.64 (a)
MTERFD2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTERFD2 35
  • 81.75 (n)
  • 74.62 (a)
MTERFD2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTERFD2 35
  • 75.73 (n)
  • 69.3 (a)
mouse
(Mus musculus)
Mammalia Mterfd2 35
  • 77.08 (n)
  • 66.56 (a)
Mterfd2 16
Mterfd2 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTERFD2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTERFD2 36
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mterfd2 35
  • 78.01 (n)
  • 66.57 (a)
lizard
(Anolis carolinensis)
Reptilia MTERFD2 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mterfd2 35
  • 50.81 (n)
  • 39.21 (a)
zebrafish
(Danio rerio)
Actinopterygii MTERFD2 36
  • 36 (a)
OneToOne
si:dkeyp-94h10.5 35
  • 52.19 (n)
  • 43.86 (a)
worm
(Caenorhabditis elegans)
Secernentea K11D2.5 36
  • 22 (a)
OneToOne
Species with no ortholog for MTERF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTERF4 Gene

ENSEMBL:
Gene Tree for MTERF4 (if available)
TreeFam:
Gene Tree for MTERF4 (if available)

Paralogs for MTERF4 Gene

No data available for Paralogs for MTERF4 Gene

Variants for MTERF4 Gene

Sequence variations from dbSNP and Humsavar for MTERF4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2240539 -- 241,096,129(+) ATCCA(C/G)ACTTG reference, missense, nc-transcript-variant, intron-variant
rs2286323 -- 241,097,382(+) GGCGC(A/G)TGGTG missense, reference, nc-transcript-variant, intron-variant
rs2286324 -- 241,102,313(+) AAGCA(A/G)CGGTC utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs3796093 -- 241,099,783(+) GGCTG(C/T)AGTCA reference, missense, nc-transcript-variant, intron-variant
rs4643537 -- 241,100,151(-) GTCCC(C/T)GCTCC intron-variant

Relevant External Links for MTERF4 Gene

HapMap Linkage Disequilibrium report
MTERF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTERF4 Gene

Disorders for MTERF4 Gene

No disorders were found for MTERF4 Gene.

No data available for UniProtKB/Swiss-Prot for MTERF4 Gene

Publications for MTERF4 Gene

  1. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. (PMID: 21531335) Camara Y. … Larsson N.G. (Cell Metab. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A family of putative transcription termination factors shared amongst metazoans and plants. (PMID: 16193327) Linder T. … Gustafsson C.M. (Curr. Genet. 2005) 2 3
  5. Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. (PMID: 22949673) Spahr H. … Hallberg B.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4

Products for MTERF4 Gene

Sources for MTERF4 Gene

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