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Aliases for MTERF3 Gene

Aliases for MTERF3 Gene

  • Mitochondrial Transcription Termination Factor 3 2 3 4
  • MTERF Domain-Containing Protein 1, Mitochondrial 3 4
  • MTERF Domain Containing 1 2 3
  • MTERFD1 3 4
  • Transcription Termination Factor 3, Mitochondrial 3
  • CGI-12 3
  • MTERF3 4

External Ids for MTERF3 Gene

Previous Symbols for MTERF3 Gene


Summaries for MTERF3 Gene

GeneCards Summary for MTERF3 Gene

MTERF3 (Mitochondrial Transcription Termination Factor 3) is a Protein Coding gene. Among its related pathways are Mitochondrial Gene Expression.

UniProtKB/Swiss-Prot for MTERF3 Gene

  • Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF3 Gene

Genomics for MTERF3 Gene

Genomic Location for MTERF3 Gene

96,239,398 bp from pter
96,261,613 bp from pter
22,216 bases
Minus strand

Genomic View for MTERF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTERF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF3 Gene

No data available for Regulatory Elements for MTERF3 Gene

Proteins for MTERF3 Gene

  • Protein details for MTERF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription termination factor 3, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B3KMG6
    • G3V130
    • Q9Y301

    Protein attributes for MTERF3 Gene

    417 amino acids
    Molecular mass:
    47971 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD27721.1; Type=Frameshift; Positions=261, 262; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MTERF3 Gene

    Alternative splice isoforms for MTERF3 Gene


neXtProt entry for MTERF3 Gene

Proteomics data for MTERF3 Gene at MOPED

Post-translational modifications for MTERF3 Gene

No Post-translational modifications

Other Protein References for MTERF3 Gene

No data available for DME Specific Peptides for MTERF3 Gene

Domains for MTERF3 Gene

Protein Domains for MTERF3 Gene



  • Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape.:
    • Q96E29
  • Belongs to the mTERF family.:
    • Q96E29
genes like me logo Genes that share domains with MTERF3: view

No data available for Gene Families for MTERF3 Gene

Function for MTERF3 Gene

Molecular function for MTERF3 Gene

UniProtKB/Swiss-Prot Function: Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).

Gene Ontology (GO) - Molecular Function for MTERF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0044212 transcription regulatory region DNA binding IDA 17662942
genes like me logo Genes that share ontologies with MTERF3: view
genes like me logo Genes that share phenotypes with MTERF3: view

Animal Models for MTERF3 Gene

MGI Knock Outs for MTERF3:

miRNA for MTERF3 Gene

miRTarBase miRNAs that target MTERF3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTERF3 Gene

Localization for MTERF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF3 Gene


Gene Ontology (GO) - Cellular Components for MTERF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 17662942
genes like me logo Genes that share ontologies with MTERF3: view

Pathways for MTERF3 Gene

SuperPathways for MTERF3 Gene

genes like me logo Genes that share pathways with MTERF3: view

Pathways by source for MTERF3 Gene

1 BioSystems pathway for MTERF3 Gene

Gene Ontology (GO) - Biological Process for MTERF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0045892 negative regulation of transcription, DNA-templated IMP 17662942
genes like me logo Genes that share ontologies with MTERF3: view

Transcripts for MTERF3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF3 Gene

No ASD Table

Relevant External Links for MTERF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MTERF3 Gene

mRNA expression in normal human tissues for MTERF3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTERF3 Gene

mRNA Expression by UniProt/SwissProt for MTERF3 Gene

Tissue specificity: Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.
genes like me logo Genes that share expressions with MTERF3: view

Orthologs for MTERF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTERF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MTERFD1 36
  • 99.76 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia MTERFD1 36
  • 86.81 (n)
  • 81.29 (a)
  • 81 (a)
(Canis familiaris)
Mammalia MTERFD1 36
  • 87.69 (n)
  • 85.61 (a)
  • 86 (a)
(Mus musculus)
Mammalia Mterfd1 36
  • 81.8 (n)
  • 76.94 (a)
Mterfd1 16
Mterfd1 37
  • 77 (a)
(Monodelphis domestica)
Mammalia MTERFD1 37
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MTERFD1 37
  • 67 (a)
(Rattus norvegicus)
Mammalia Mterfd1 36
  • 82.8 (n)
  • 78 (a)
(Gallus gallus)
Aves MTERFD1 36
  • 69.86 (n)
  • 63.47 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia MTERFD1 37
  • 45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24024 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394691 36
mterfd1 36
  • 67.27 (n)
  • 69.7 (a)
(Danio rerio)
Actinopterygii mterfd1 36
  • 60.85 (n)
  • 61.74 (a)
mterfd1 37
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012143 36
  • 48.02 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta mTerf3 36
  • 48.05 (n)
  • 40.51 (a)
mTerf3 37
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C50F4.12 37
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
Species with no ortholog for MTERF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTERF3 Gene

Gene Tree for MTERF3 (if available)
Gene Tree for MTERF3 (if available)

Paralogs for MTERF3 Gene

No data available for Paralogs for MTERF3 Gene

Variants for MTERF3 Gene

Sequence variations from dbSNP and Humsavar for MTERF3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs871798 -- 96,245,754(+) CTTAT(C/T)TTAAA intron-variant
rs1568224 -- 96,245,382(-) TGCCA(A/G)CTCTC intron-variant
rs1878638 -- 96,246,491(-) TGTAA(A/G)TGTTT intron-variant
rs2030219 -- 96,239,725(+) CACAC(A/G)GGAGG intron-variant
rs2319603 -- 96,258,763(+) AAAAC(A/G)GTATT intron-variant, upstream-variant-2KB

Relevant External Links for MTERF3 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for MTERF3 Gene

Disorders for MTERF3 Gene

No disorders were found for MTERF3 Gene.

No data available for UniProtKB/Swiss-Prot for MTERF3 Gene

Publications for MTERF3 Gene

  1. MTERF3 is a negative regulator of mammalian mtDNA transcription. (PMID: 17662942) Park C.B. … Larsson N.G. (Cell 2007) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A family of putative transcription termination factors shared amongst metazoans and plants. (PMID: 16193327) Linder T. … Gustafsson C.M. (Curr. Genet. 2005) 2 3

Products for MTERF3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MTERF3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MTERF3
    • Block miRNA regulation of MTERF3 using miScript Target Protectors

    Sources for MTERF3 Gene

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