Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTERF2 Gene

Aliases for MTERF2 Gene

  • Mitochondrial Transcription Termination Factor 2 2 3 4
  • Mitochondrial Transcription Termination Factor-Like Protein 3 4
  • MTERF Domain-Containing Protein 3, Mitochondrial 3 4
  • MTERF Domain Containing 3 2 3
  • MTERFD3 3 4
  • MTERFL 3 4
  • MTERF2 4

External Ids for MTERF2 Gene

Previous HGNC Symbols for MTERF2 Gene

  • MTERFD3

Summaries for MTERF2 Gene

GeneCards Summary for MTERF2 Gene

MTERF2 (Mitochondrial Transcription Termination Factor 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and double-stranded DNA binding. An important paralog of this gene is MTERF1.

UniProtKB/Swiss-Prot for MTERF2 Gene

  • Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF2 Gene

Genomics for MTERF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTERF2 Gene

Chromosome:
12
Start:
106,977,291 bp from pter
End:
106,987,166 bp from pter
Size:
9,876 bases
Orientation:
Minus strand

Genomic View for MTERF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTERF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF2 Gene

No data available for Regulatory Elements for MTERF2 Gene

Proteins for MTERF2 Gene

  • Protein details for MTERF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AM1-MTEF2_HUMAN
    Recommended name:
    Transcription termination factor 2, mitochondrial
    Protein Accession:
    Q49AM1
    Secondary Accessions:
    • Q53HM2
    • Q9H4L6
    • Q9H7Y9

    Protein attributes for MTERF2 Gene

    Size:
    385 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    • Monomer. Homodimer (By similarity).

neXtProt entry for MTERF2 Gene

Proteomics data for MTERF2 Gene at MOPED

Post-translational modifications for MTERF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTERF2 Gene

No data available for DME Specific Peptides for MTERF2 Gene

Domains & Families for MTERF2 Gene

Protein Domains for MTERF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTERF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q49AM1

UniProtKB/Swiss-Prot:

MTEF2_HUMAN :
  • Belongs to the mTERF family.
Family:
  • Belongs to the mTERF family.
genes like me logo Genes that share domains with MTERF2: view

No data available for Gene Families for MTERF2 Gene

Function for MTERF2 Gene

Molecular function for MTERF2 Gene

UniProtKB/Swiss-Prot Function:
Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity).

Gene Ontology (GO) - Molecular Function for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0003690 double-stranded DNA binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with MTERF2: view
genes like me logo Genes that share phenotypes with MTERF2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTERF2 Gene

Localization for MTERF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF2 Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Gene Ontology (GO) - Cellular Components for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix ISS --
GO:0042645 mitochondrial nucleoid IEA --
genes like me logo Genes that share ontologies with MTERF2: view

No data available for Subcellular locations from COMPARTMENTS for MTERF2 Gene

Pathways & Interactions for MTERF2 Gene

SuperPathways for MTERF2 Gene

No Data Available

Interacting Proteins for MTERF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000240050%0d%0a9606.ENSP00000400168%0d%0a9606.ENSP00000450995%0d%0a
Selected Interacting proteins: ENSP00000240050 for MTERF2 Gene via STRING

Gene Ontology (GO) - Biological Process for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated ISS --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006393 termination of mitochondrial transcription IBA --
genes like me logo Genes that share ontologies with MTERF2: view

No data available for Pathways by source and SIGNOR curated interactions for MTERF2 Gene

Drugs & Compounds for MTERF2 Gene

No Compound Related Data Available

Transcripts for MTERF2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTERF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: -
SP4: - - - - -
SP5:
SP6:

Relevant External Links for MTERF2 Gene

GeneLoc Exon Structure for
MTERF2
ECgene alternative splicing isoforms for
MTERF2

Expression for MTERF2 Gene

mRNA expression in normal human tissues for MTERF2 Gene

mRNA Expression by UniProt/SwissProt for MTERF2 Gene

Q49AM1-MTEF2_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, liver and pancreas.
genes like me logo Genes that share expression patterns with MTERF2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MTERF2 Gene

Orthologs for MTERF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTERF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTERFD3 35
  • 90.56 (n)
  • 87.79 (a)
MTERFD3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mterfd3 35
  • 80.09 (n)
  • 76.36 (a)
Mterfd3 16
Mterfd3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTERFD3 35
  • 99.65 (n)
  • 98.96 (a)
MTERFD3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mterfd3 35
  • 79.39 (n)
  • 75.58 (a)
dog
(Canis familiaris)
Mammalia MTERFD3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTERFD3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTERFD3 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTERFD3 35
  • 68.71 (n)
  • 67.41 (a)
MTERFD3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTERFD3 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485703 35
  • 61.14 (n)
  • 52.57 (a)
zebrafish
(Danio rerio)
Actinopterygii mterfd3 35
  • 54 (n)
  • 49.43 (a)
mterfd3 36
  • 48 (a)
OneToOne
Species with no ortholog for MTERF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTERF2 Gene

ENSEMBL:
Gene Tree for MTERF2 (if available)
TreeFam:
Gene Tree for MTERF2 (if available)

Paralogs for MTERF2 Gene

Paralogs for MTERF2 Gene

genes like me logo Genes that share paralogs with MTERF2: view

Variants for MTERF2 Gene

Sequence variations from dbSNP and Humsavar for MTERF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs714359 -- 106,985,067(+) CTCCC(A/G)TACAA intron-variant
rs1043156 -- 106,978,499(-) TTAGA(A/G)GATGA synonymous-codon, reference
rs1043157 - 106,978,123(-) TAGAT(A/G)TAGGT missense, reference
rs1990700 -- 106,988,381(-) CACCC(C/T)CCAGC upstream-variant-2KB
rs2287160 -- 106,987,397(-) TAAGC(A/C/G)TCAAA upstream-variant-2KB

Variation tolerance for MTERF2 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTERF2 Gene

HapMap Linkage Disequilibrium report
MTERF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTERF2 Gene

Disorders for MTERF2 Gene

Relevant External Links for MTERF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTERF2
genes like me logo Genes that share disorders with MTERF2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTERF2 Gene

Publications for MTERF2 Gene

  1. MTERF2 is a nucleoid component in mammalian mitochondria. (PMID: 19366608) Pellegrini M. … Gustafsson C.M. (Biochim. Biophys. Acta 2009) 2 67
  2. A family of putative transcription termination factors shared amongst metazoans and plants. (PMID: 16193327) Linder T. … Gustafsson C.M. (Curr. Genet. 2005) 2 67
  3. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. (PMID: 16226716) Chen Y. … Tan D. (Biochem. Biophys. Res. Commun. 2005) 23 67
  4. Identification of a transcription factor like protein at the TOR locus in Leishmania mexicana amazonensis. (PMID: 9476797) Detke S. (Mol. Biochem. Parasitol. 1997) 23 67
  5. Body axis determination during early development in amphibians. (PMID: 1363624) Savard P. (Biochem. Cell Biol. 1992) 23 67

Products for MTERF2 Gene

Sources for MTERF2 Gene

Back to Top

Content