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Aliases for MTERF2 Gene

Aliases for MTERF2 Gene

  • Mitochondrial Transcription Termination Factor 2 2 3 4 5
  • Mitochondrial Transcription Termination Factor-Like Protein 3 4
  • MTERF Domain-Containing Protein 3, Mitochondrial 3 4
  • MTERF Domain Containing 3 2 3
  • MTERF-Like 3 4
  • MTERFD3 3 4
  • MTERFL 3 4
  • Transcription Termination Factor 2, Mitochondrial 3
  • MTERF2 4

External Ids for MTERF2 Gene

Previous HGNC Symbols for MTERF2 Gene

  • MTERFD3

Summaries for MTERF2 Gene

GeneCards Summary for MTERF2 Gene

MTERF2 (Mitochondrial Transcription Termination Factor 2) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and double-stranded DNA binding. An important paralog of this gene is MTERF1.

UniProtKB/Swiss-Prot for MTERF2 Gene

  • Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF2 Gene

Genomics for MTERF2 Gene

Regulatory Elements for MTERF2 Gene

Enhancers for MTERF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G106073 1.6 Ensembl ENCODE dbSUPER 20.8 +907.5 907468 12.6 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF302 FOS ZNF263 JUNB MTERF2 ENSG00000260329 ENSG00000257890 CKAP4 GC12M106085
GH12G106299 1.8 FANTOM5 ENCODE dbSUPER 10.4 +684.8 684809 5.7 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 ENSG00000260329 POLR3B MTERF2 TCP11L2 TMEM263 CKAP4
GH12G107090 1.4 ENCODE dbSUPER 13.2 -105.8 -105808 4.3 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CRY1 MTERF2 ENSG00000257398 ENSG00000257548 PIR33339
GH12G107025 1.1 Ensembl ENCODE 15.2 -40.6 -40592 4.8 FOXA2 FEZF1 BMI1 RFX5 YY1 GATA2 ZSCAN5C SCRT2 FOS ZNF362 MTERF2 CRY1 GC12P107027 GC12M107024
GH12G106958 1 Ensembl 12.5 +28.4 28366 0.8 FOXA2 MLX ARID4B SIN3A ZNF48 SLC30A9 SP5 PPARG KAT8 NFIL3 MTERF2 GC12M106953 GC12P106984
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTERF2 on UCSC Golden Path with GeneCards custom track

Promoters for MTERF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056912 166 1201 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2

Genomic Location for MTERF2 Gene

Chromosome:
12
Start:
106,977,291 bp from pter
End:
106,987,166 bp from pter
Size:
9,876 bases
Orientation:
Minus strand

Genomic View for MTERF2 Gene

Genes around MTERF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTERF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTERF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF2 Gene

Proteins for MTERF2 Gene

  • Protein details for MTERF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AM1-MTEF2_HUMAN
    Recommended name:
    Transcription termination factor 2, mitochondrial
    Protein Accession:
    Q49AM1
    Secondary Accessions:
    • Q53HM2
    • Q9H4L6
    • Q9H7Y9

    Protein attributes for MTERF2 Gene

    Size:
    385 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    • Monomer. Homodimer (By similarity).

neXtProt entry for MTERF2 Gene

Post-translational modifications for MTERF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTERF2 Gene

Domains & Families for MTERF2 Gene

Protein Domains for MTERF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTERF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q49AM1

UniProtKB/Swiss-Prot:

MTEF2_HUMAN :
  • Belongs to the mTERF family.
Family:
  • Belongs to the mTERF family.
genes like me logo Genes that share domains with MTERF2: view

No data available for Gene Families for MTERF2 Gene

Function for MTERF2 Gene

Molecular function for MTERF2 Gene

UniProtKB/Swiss-Prot Function:
Binds promoter DNA and regulates mitochondrial transcription. Required for normal levels of transcription, both for mRNA and tRNA. Required for normal mitochondrial protein synthesis, assembly of respiratory complexes and normal mitochondrial function (By similarity).

Gene Ontology (GO) - Molecular Function for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0003690 double-stranded DNA binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with MTERF2: view
genes like me logo Genes that share phenotypes with MTERF2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MTERF2 Gene

Localization for MTERF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF2 Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTERF2 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix ISS,IBA --
GO:0042645 mitochondrial nucleoid IEA --
genes like me logo Genes that share ontologies with MTERF2: view

Pathways & Interactions for MTERF2 Gene

SuperPathways for MTERF2 Gene

No Data Available

Interacting Proteins for MTERF2 Gene

Gene Ontology (GO) - Biological Process for MTERF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated ISS --
GO:0006355 regulation of transcription, DNA-templated IEA,ISS --
GO:0006393 termination of mitochondrial transcription IBA --
genes like me logo Genes that share ontologies with MTERF2: view

No data available for Pathways by source and SIGNOR curated interactions for MTERF2 Gene

Transcripts for MTERF2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: -
SP4: - - - - -
SP5:
SP6:

Relevant External Links for MTERF2 Gene

GeneLoc Exon Structure for
MTERF2
ECgene alternative splicing isoforms for
MTERF2

Expression for MTERF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTERF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTERF2 Gene:

MTERF2

mRNA Expression by UniProt/SwissProt for MTERF2 Gene:

Q49AM1-MTEF2_HUMAN
Tissue specificity: Expressed in skeletal muscle, heart, liver and pancreas.

Evidence on tissue expression from TISSUES for MTERF2 Gene

  • Nervous system(4.3)
  • Bone marrow(4.1)
  • Lymph node(4.1)
genes like me logo Genes that share expression patterns with MTERF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTERF2 Gene

Orthologs for MTERF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTERF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTERFD3 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia MTERFD3 34 35
  • 90.56 (n)
dog
(Canis familiaris)
Mammalia MTERFD3 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mterfd3 34 35
  • 80.09 (n)
Mterf2 16
rat
(Rattus norvegicus)
Mammalia Mterfd3 34
  • 79.39 (n)
oppossum
(Monodelphis domestica)
Mammalia MTERFD3 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTERFD3 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTERFD3 34 35
  • 68.71 (n)
lizard
(Anolis carolinensis)
Reptilia MTERFD3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485703 34
  • 61.14 (n)
zebrafish
(Danio rerio)
Actinopterygii mterfd3 34 35
  • 54 (n)
Species where no ortholog for MTERF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTERF2 Gene

ENSEMBL:
Gene Tree for MTERF2 (if available)
TreeFam:
Gene Tree for MTERF2 (if available)

Paralogs for MTERF2 Gene

Paralogs for MTERF2 Gene

genes like me logo Genes that share paralogs with MTERF2: view

Variants for MTERF2 Gene

Sequence variations from dbSNP and Humsavar for MTERF2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000156561 -- 106,983,173(+) ATATA(A/C)ATAAC intron-variant
rs1000264003 -- 106,982,680(+) GCTAT(G/T)TGTAA intron-variant
rs1000446463 -- 106,982,767(+) TGACT(A/G)AAGAG intron-variant
rs1000710302 -- 106,988,809(+) ATCAG(-/A)AAAAA upstream-variant-2KB
rs1001717459 -- 106,984,460(+) ACCAC(A/T)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTERF2 Gene

Variant ID Type Subtype PubMed ID
nsv437155 CNV loss 16327808

Variation tolerance for MTERF2 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTERF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTERF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTERF2 Gene

Disorders for MTERF2 Gene

Relevant External Links for MTERF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTERF2

No disorders were found for MTERF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTERF2 Gene

Publications for MTERF2 Gene

  1. MTERF2 is a nucleoid component in mammalian mitochondria. (PMID: 19366608) Pellegrini M. … Gustafsson C.M. (Biochim. Biophys. Acta 2009) 2 3 4 64
  2. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. (PMID: 16226716) Chen Y. … Tan D. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  3. A family of putative transcription termination factors shared amongst metazoans and plants. (PMID: 16193327) Linder T. … Gustafsson C.M. (Curr. Genet. 2005) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MTERF2 Gene

Sources for MTERF2 Gene

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