Aliases for MTERF1 Gene
External Ids for MTERF1 Gene
Previous HGNC Symbols for MTERF1 Gene
This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
GeneCards Summary for MTERF1 Gene
MTERF1 (Mitochondrial Transcription Termination Factor 1) is a Protein Coding gene. Diseases associated with MTERF1 include melas syndrome. Among its related pathways are Gene Expression and Transcriptional activation of mitochondrial biogenesis. GO annotations related to this gene include poly(A) RNA binding and double-stranded DNA binding. An important paralog of this gene is MTERF2.
UniProtKB/Swiss-Prot for MTERF1 Gene
Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.