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Aliases for MTERF1 Gene

Aliases for MTERF1 Gene

  • Mitochondrial Transcription Termination Factor 1 2 3 4
  • MTERF 3 4 6
  • Transcription Termination Factor 1, Mitochondrial 3
  • Transcription Termination Factor, Mitochondrial 3
  • Mitochondrial Transcription Termination Factor 2
  • MTERF1 4

External Ids for MTERF1 Gene

Previous HGNC Symbols for MTERF1 Gene

  • MTERF

Summaries for MTERF1 Gene

Entrez Gene Summary for MTERF1 Gene

  • This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTERF1 Gene

MTERF1 (Mitochondrial Transcription Termination Factor 1) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase I Promoter Opening. An important paralog of this gene is MTERF2.

UniProtKB/Swiss-Prot for MTERF1 Gene

  • Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.

Gene Wiki entry for MTERF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTERF1 Gene

Genomics for MTERF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTERF1 Gene

Start:
91,692,008 bp from pter
End:
91,880,720 bp from pter
Size:
188,713 bases
Orientation:
Minus strand

Genomic View for MTERF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTERF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTERF1 Gene

No data available for Regulatory Elements for MTERF1 Gene

Proteins for MTERF1 Gene

  • Protein details for MTERF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99551-MTEF1_HUMAN
    Recommended name:
    Transcription termination factor 1, mitochondrial
    Protein Accession:
    Q99551
    Secondary Accessions:
    • A4D1E3
    • Q32NF8
    • Q53H51
    • Q9BVR7

    Protein attributes for MTERF1 Gene

    Size:
    399 amino acids
    Molecular mass:
    45778 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for MTERF1 Gene

neXtProt entry for MTERF1 Gene

Proteomics data for MTERF1 Gene at MOPED

Post-translational modifications for MTERF1 Gene

  • Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTERF1 Gene

No data available for DME Specific Peptides for MTERF1 Gene

Domains for MTERF1 Gene

Protein Domains for MTERF1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99551

UniProtKB/Swiss-Prot:

MTEF1_HUMAN :
  • Q99551
Domain:
  • Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA.
Family:
  • Belongs to the mTERF family.
genes like me logo Genes that share domains with MTERF1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MTERF1 Gene

Function for MTERF1 Gene

Molecular function for MTERF1 Gene

UniProtKB/Swiss-Prot Function:
Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.

Gene Ontology (GO) - Molecular Function for MTERF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IDA 20550934
GO:0005515 protein binding IPI 20195357
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MTERF1: view

Phenotypes for MTERF1 Gene

MGI mutant phenotypes for MTERF1:
inferred from 2 alleles
GenomeRNAi human phenotypes for MTERF1:
genes like me logo Genes that share phenotypes with MTERF1: view

Animal Models for MTERF1 Gene

MGI Knock Outs for MTERF1:

miRNA for MTERF1 Gene

miRTarBase miRNAs that target MTERF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTERF1 Gene

Localization for MTERF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTERF1 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for MTERF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9118945
GO:0005759 mitochondrial matrix TAS --
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with MTERF1: view

No data available for Subcellular locations from COMPARTMENTS for MTERF1 Gene

Pathways for MTERF1 Gene

genes like me logo Genes that share pathways with MTERF1: view

Interacting Proteins for MTERF1 Gene

Gene Ontology (GO) - Biological Process for MTERF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006353 DNA-templated transcription, termination IDA 20550934
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006390 transcription from mitochondrial promoter TAS --
GO:0006393 termination of mitochondrial transcription TAS --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with MTERF1: view

Compounds for MTERF1 Gene

(2) Novoseek inferred chemical compound relationships for MTERF1 Gene

Compound -log(P) Hits PubMed IDs
s-adenosylmethionine 47.2 1
rrna 43.7 1
genes like me logo Genes that share compounds with MTERF1: view

Transcripts for MTERF1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTERF1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTERF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - - - -
SP2: -
SP3: - - - - - -
SP4: - - - - -
SP5:

Relevant External Links for MTERF1 Gene

GeneLoc Exon Structure for
MTERF1
ECgene alternative splicing isoforms for
MTERF1

Expression for MTERF1 Gene

mRNA expression in normal human tissues for MTERF1 Gene

Protein differential expression in normal tissues for MTERF1 Gene

This gene is overexpressed in Lung (67.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTERF1 Gene

genes like me logo Genes that share expressions with MTERF1: view

Expression partners for MTERF1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTERF1 Gene

Orthologs for MTERF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTERF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTERF 35
  • 87.65 (n)
  • 80.05 (a)
MTERF 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTERF 35
  • 86.87 (n)
  • 81.09 (a)
MTERF 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mterf1b 35
  • 81.91 (n)
  • 76.06 (a)
Mterf 16
Gm9897 36
  • 75 (a)
OneToMany
Mterf 36
  • 75 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MTERF 35
  • 99.25 (n)
  • 98.75 (a)
MTERF 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTERF 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTERF 36
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15029 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536997 35
  • 51.66 (n)
  • 46.49 (a)
MTERF 36
  • 43 (a)
OneToOne
Species with no ortholog for MTERF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTERF1 Gene

ENSEMBL:
Gene Tree for MTERF1 (if available)
TreeFam:
Gene Tree for MTERF1 (if available)

Paralogs for MTERF1 Gene

Paralogs for MTERF1 Gene

Pseudogenes.org Pseudogenes for MTERF1 Gene

genes like me logo Genes that share paralogs with MTERF1: view

Variants for MTERF1 Gene

Sequence variations from dbSNP and Humsavar for MTERF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9008 -- 91,873,093(+) ATCAT(C/G)TACTT utr-variant-3-prime
rs1011372 -- 91,880,553(+) CCTCC(C/T)CCAAA intron-variant
rs2106745 -- 91,877,321(+) AATTC(C/T)TAACA intron-variant
rs2269810 -- 91,879,523(+) TCAGA(C/T)GAAAA intron-variant
rs2269811 -- 91,880,237(+) CCTCT(C/T)GCAAA intron-variant

Relevant External Links for MTERF1 Gene

HapMap Linkage Disequilibrium report
MTERF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTERF1 Gene

Disorders for MTERF1 Gene

(1) Novoseek inferred disease relationships for MTERF1 Gene

Disease -log(P) Hits PubMed IDs
heart failure 10.1 2
genes like me logo Genes that share disorders with MTERF1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for MTERF1 Gene

Publications for MTERF1 Gene

  1. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. (PMID: 9118945) Fernandez-Silva P. … Attardi G. (EMBO J. 1997) 3 4 23
  2. The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form. (PMID: 15899902) Asin-Cayuela J. … Gustafsson C.M. (J. Biol. Chem. 2005) 2 3 23
  3. Training response of mitochondrial transcription factors in human skeletal muscle. (PMID: 19681768) Norrbom J. … Sundberg C.J. (Acta Physiol (Oxf) 2010) 3 23
  4. Molecular characterization of the transcription termination factor from human mitochondria. (PMID: 7681833) Daga A. … Attardi G. (J. Biol. Chem. 1993) 2 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for MTERF1 Gene

Sources for MTERF1 Gene

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