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MTERF Gene

protein-coding   GIFtS: 56
GCID: GC07M091340

Mitochondrial Transcription Termination Factor

  See MTERF-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Transcription Termination Factor1 2
Mitochondrial Transcription Termination Factor 12 3
mTERF12 3
Transcription Termination Factor, Mitochondrial2
mTERF3

External Ids:    HGNC: 214631   Entrez Gene: 79782   Ensembl: ENSG000001279897   OMIM: 6023185   UniProtKB: Q995513   
ORGUL members:         

Export aliases for MTERF gene to outside databases

Previous GC identifers: GC07M090037 GC07M090766 GC07M091114 GC07M091112 GC07M091146 GC07M091500 GC07M086109


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTERF Gene:
This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating
transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal
RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by
two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers
participate in intramolecular interactions that establish the three-dimensional structure required for DNA
binding. (provided by RefSeq, Jul 2008)

GeneCards Summary for MTERF Gene:
MTERF (mitochondrial transcription termination factor) is a protein-coding gene. Diseases associated with MTERF include melas syndrome. GO annotations related to this gene include double-stranded DNA binding. An important paralog of this gene is MTERFD3.

UniProtKB/Swiss-Prot: MTERF_HUMAN, Q99551
Function: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position
immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical
for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial
unwinding. Promotes base flipping. Probably requires one or more components for termination activity

Gene Wiki entry for MTERF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTERF gene promoter:
         AhR   TBP   FOXD3   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   Arnt   TFIID   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MTERF promoter sequence
   Search Chromatin IP Primers for MTERF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTERF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21-q22

MTERF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTERF gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M091340:  view genomic region     (about GC identifiers)

Start:
91,321,323 bp from pter      End:
91,510,034 bp from pter
Size:
188,712 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 90,832,721-90,840,716     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MTERF_HUMAN, Q99551 (See protein sequence)
Recommended Name: Transcription termination factor, mitochondrial precursor  
Size: 399 amino acids; 45778 Da
Subunit: Monomer
4 PDB 3D structures from and Proteopedia for MTERF:
3MVA (3D)        3MVB (3D)        3N6S (3D)        3N7Q (3D)    
Secondary accessions: A4D1E3 Q32NF8 Q53H51 Q9BVR7

Explore the universe of human proteins at neXtProt for MTERF: NX_Q99551

Explore proteomics data for MTERF at MOPED

Post-translational modifications: 

  • Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the
    phosphorylation state, only the phosphorylated form of the protein is active for termination activity.
    Functioning seems to be regulated by phosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MTERF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008911.1  
    ENSEMBL proteins: 
     ENSP00000414116   ENSP00000248643   ENSP00000384986   ENSP00000402175   ENSP00000395097  
     ENSP00000400966  
    Reactome Protein details: Q99551

    MTERF Human Recombinant Protein Products:

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    antibodies-online proteins for MTERF (8 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003690 Mit_transcrip_term-rel

    Graphical View of Domain Structure for InterPro Entry Q99551

    ProtoNet protein and cluster: Q99551

    UniProtKB/Swiss-Prot: MTERF_HUMAN, Q99551
    Domain: Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The
    repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA
    Similarity: Belongs to the mTERF family


    Find genes that share domains with MTERF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTERF_HUMAN, Q99551
    Function: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position
    immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical
    for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial
    unwinding. Promotes base flipping. Probably requires one or more components for termination activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA--
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MTERF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MTERF:
     Increased S DNA content 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mterf):
     cellular  no phenotypic analysis 

    Find genes that share phenotypes with MTERF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MTERF: Mterf1atm1.2Lrsn Mterf1atm1.1Lrsn

       genOway: Develop your customized and physiologically relevant rodent model for MTERF

    miRNA
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    miRTarBase miRNAs that target MTERF:
    hsa-mir-26b-5p (MIRT029022)

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTERF_HUMAN, Q99551: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9118945
    GO:0005759mitochondrial matrix TAS--
    GO:0042645mitochondrial nucleoid IDA18063578

    Find genes that share ontologies with MTERF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTERF About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    Transcription from mitochondrial promoters0.00
    Mitochondrial transcription termination0.00
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with MTERF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for MTERF
        Mitochondrial transcription termination
    Transcriptional activation of mitochondrial biogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTERF
    Interactions:

        Search GeneGlobe Interaction Network for MTERF

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for MTERF (Q995511, 2, 3 ENSP000002486434) via UniProtKB, MINT, STRING, and/or I2D (see all 256)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJC21Q5F1R61, 3EBI-2690033,EBI-2654581 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PTCD1O751272, ENSP000002924784MINT-8079030 STRING: ENSP00000292478
    ANK2Q014843I2D: score=1 
    CTNNAL1Q9UBT73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006353DNA-templated transcription, termination IDA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006390transcription from mitochondrial promoter TAS--
    GO:0006393termination of mitochondrial transcription TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with MTERF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTERF

    2 Novoseek inferred chemical compound relationships for MTERF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 47.2 1 11809803 (1)
    rrna 43.7 1 1584755 (1)



    Find genes that share compounds with MTERF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTERF gene: 
    NM_006980.3  

    Unigene Cluster for MTERF:

    Mitochondrial transcription termination factor
    Hs.532216  [show with all ESTs]
    Unigene Representative Sequence: AL832861
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454222(uc010let.1) ENST00000419292(uc003ulc.1 uc011khm.1 uc010leu.1)
    ENST00000351870 ENST00000406735 ENST00000456229 ENST00000442961 ENST00000425936
    ENST00000481516
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MTERF
      QuantiFast Probe-based Assays in human, mouse, rat MTERF

    Additional mRNA sequence: 

    AK222730.1 AK298469.1 AK311568.1 AK313641.1 AL832861.1 BC000965.3 BC108648.1 BC130389.1 
    BC130391.1 Y09615.1 

    9 DOTS entries:

    DT.95189567  DT.210848  DT.121056782  DT.91744176  DT.100752012  DT.121056831  DT.95348269  DT.100734944 
    DT.121056789 

    Selected AceView cDNA sequences (see all 87):

    BU902561 BE219491 BU740531 BU689718 CR596059 CA446435 AL832861 BM722850 
    CB160953 AA988723 AI801961 BG940796 CA941517 AI041411 BQ221481 CR608572 
    CF529904 BG743431 BQ229464 BG942684 CA941224 BG180067 NM_006980 Y09615 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTERF    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:                    -     -           -     -     -                     
    SP2:                                      -                                 
    SP3:                    -     -     -     -     -     -                     
    SP4:                          -     -     -     -     -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for MTERF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTERF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MTERF Expression
    About this image

    MTERF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTERF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532216
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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MTERF gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mterf5
    Mterf1b1
    mitochondrial transcription termination factor5
    mitochondrial transcription termination factor 1b1
    81.91(n)1
    76.06(a)1
      5 (2.26 cM)5
    2085951  NM_001042670.11  NP_001036135.21 
     38905815 
    lizard
    (Anolis carolinensis)
    Reptilia MTERF6
    mitochondrial transcription termination factor
    45(a)
    1 ↔ 1
    6(20958382-20959572)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.150292 Xenopus laevis transcribed sequence with weak similarity more 70.51(n)    BJ068643.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005369971 transcription termination factor, mitochondrial-like 51.66(n)
    46.49(a)
      100536997  XM_003200502.2  XP_003200550.1 


    ENSEMBL Gene Tree for MTERF (if available)
    TreeFam Gene Tree for MTERF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTERF gene
    MTERFD32  
    1 SIMAP similar gene for MTERF using alignment to 5 protein entries:     MTERF_HUMAN (see all proteins):
    MTERFD3

    Find genes that share paralogs with MTERF           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MTERF
    PGOHUM00000238046


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTERF (see all 180)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437805411,2
    C--91501528(+) TGAACC/TGTGTT 1 -- ds50010--------
    rs77868891,2
    C,A--91501533(+) tgtgtC/Tagact 1 -- ds50010--------
    rs1481332451,2
    --91501567(+) GAATTA/GTGTAT 1 -- ds50010--------
    rs1419015041,2
    --91501851(+) GTATCA/GTTGAA 1 -- ds50010--------
    rs1845302871,2
    --91501861(+) ATATAC/TAAATG 1 -- ds50010--------
    rs1890669571,2
    --91501869(+) ATGGCC/TTTAGA 1 -- ds50010--------
    rs78077451,2
    A--91501886(+) GACATA/GTTGTT 1 -- ds50010--------
    rs78083371,2
    C,A,H--91502049(+) CTCACG/ATCTTT 1 -- ut31 ese36Minor allele frequency- A:0.00NS EA NA 422
    rs1813894471,2
    --91502069(+) TCAGAA/GCTAGA 1 -- ut310--------
    rs119833321,2
    C,H--91502250(+) TTTAGT/GTTTTT 1 -- ut314Minor allele frequency- G:0.00NS EA 386

    HapMap Linkage Disequilibrium report for MTERF (91321323 - 91510034 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MTERF: --
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602318    OMIM disorders: --

    1 disease for MTERF:    
    About MalaCards
    melas syndrome

    1 disease from the University of Copenhagen DISEASES database for MTERF:
    MELAS syndrome

    Find genes that share disorders with MTERF           About GenesLikeMe

    1 Novoseek inferred disease relationship for MTERF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 10.1 2 14660709 (1), 16043643 (1)

    Genetic Association Database (GAD): MTERF
    Human Genome Epidemiology (HuGE) Navigator: MTERF (2 documents)

    Export disorders for MTERF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTERF gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with MTERF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form. (PubMed id 15899902)1, 3, 9 Asin-Cayuela J....Gustafsson C.M. (J. Biol. Chem. 2005)
    2. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. (PubMed id 9118945)1, 2, 9 Fernandez-Silva P.... Attardi G. (EMBO J. 1997)
    3. Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. (PubMed id 20550934)1, 2 Yakubovskaya E.... Garcia-Diaz M. (Cell 2010)
    4. Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat. (PubMed id 20543826)1, 2 Jimenez-Menendez N.... Sola M. (Nat. Struct. Mol. Biol. 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Phosphorylation of rat mitochondrial transcription termination factor (mTERF) is required for transcription termination but not for binding to DNA. (PubMed id 15087485)1, 2 Prieto-Martin A.... Martinez-Azorin F. (Nucleic Acids Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity. (PubMed id 14744862)1, 3 Asin-Cayuela J....Attardi G. (J. Biol. Chem. 2004)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7978 HGNC: 21463 AceView: MTERF Ensembl:ENSG00000127989 euGenes: HUgn7978
    ECgene: MTERF H-InvDB: MTERF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTERF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTERF gene:
    Search GeneIP for patents involving MTERF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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