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MTDH Gene

protein-coding   GIFtS: 58
GCID: GC08P098658

Metadherin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
metadherin1 2     Metastasis Adhesion Protein2 3
Metadherin3     3D3/LYRIC2 3
AEG12 3 5     AEG-12 3
LYRIC2 3 5     3D32
Astrocyte Elevated Gene-1 Protein2 3     LYRIC/3D32
Lysine-Rich CEACAM1 Co-Isolated Protein2 3     Protein LYRIC2

External Ids:    HGNC: 296081   Entrez Gene: 921402   Ensembl: ENSG000001476497   OMIM: 6103235   UniProtKB: Q86UE43   

Export aliases for MTDH gene to outside databases

Previous GC identifers: GC08P098726 GC08P093862


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTDH Gene:
MTDH (metadherin) is a protein-coding gene. Diseases associated with MTDH include acute hemorrhagic conjunctivitis, and gallbladder adenocarcinoma. GO annotations related to this gene include transcription coactivator activity and NF-kappaB binding.

UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor
kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and
astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on
bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium.
Induces chemoresistance

Gene Wiki entry for MTDH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTDH gene promoter:
         GR   AP-1   ATF-2   Egr-4   MEF-2A   c-Jun   aMEF-2   GR-alpha   FOXO1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTDH promoter sequence
   Search Chromatin IP Primers for MTDH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

MTDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTDH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P098658:  view genomic region     (about GC identifiers)

Start:
98,656,407 bp from pter      End:
98,742,488 bp from pter
Size:
86,082 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4 (See protein sequence)
Recommended Name: Protein LYRIC  
Size: 582 amino acids; 63837 Da
Subunit: Interacts with BCCIP, CREBBP/CBP and RELA/p65
Miscellaneous: Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial
cells and the reciprocal effect is observed following overexpression
Caution: Was originally (PubMed:15093543) thought to be a type II membrane protein but this is inconsistent with
the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in
the lumen or extracellularly rather than in the cytoplasm
Secondary accessions: Q05DH2 Q52QU9 Q6PK07 Q8TCX3

Explore the universe of human proteins at neXtProt for MTDH: NX_Q86UE4

Explore proteomics data for MTDH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys107
  • Modification sites at PhosphoSitePlus

  • See MTDH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848927.2  
    ENSEMBL proteins: 
     ENSP00000338235   ENSP00000428168   ENSP00000428703   ENSP00000429289   ENSP00000429642  

    MTDH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MTDH
    OriGene Protein Over-expression Lysate for MTDH
    OriGene MassSpec for MTDH
    OriGene Custom Protein Services for MTDH
    GenScript Custom Purified and Recombinant Proteins Services for MTDH
    Novus Biologicals MTDH Protein
    Novus Biologicals MTDH Lysates
    Sino Biological Recombinant Protein for MTDH
    Sino Biological Cell Lysate for MTDH
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTDH

    MTDH Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MTDH
    R&D Systems Antibodies for MTDH (Metadherin)
    Cell Signaling Technology (CST) Antibodies for MTDH  (Lyric)
    OriGene Antibodies for MTDH
    OriGene Custom Antibody Services for MTDH
    Novus Biologicals MTDH Antibodies
    Abcam antibodies for MTDH
    Cloud-Clone Corp. Antibodies for MTDH
    ThermoFisher Antibody for MTDH
    LSBio Antibodies in human, mouse, rat for MTDH

    MTDH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTDH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTDH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTDH
    Cloud-Clone Corp. CLIAs for MTDH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q86UE4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYRIC_HUMAN, Q86UE4
    Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor
    kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and
    astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on
    bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium.
    Induces chemoresistance
    Induction: By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI18316612
    GO:0003713transcription coactivator activity IMP18316612
    GO:0003725double-stranded RNA binding IDA--
    GO:0005515protein binding IPI18316612
    GO:0044822poly(A) RNA binding IDA--
         
    MTDH for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTDH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTDH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTDH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTDH

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTDH:
    hsa-mir-192-5p (MIRT026149), hsa-mir-375 (MIRT006207), hsa-mir-30c-5p (MIRT047972), hsa-mir-26a-5p (MIRT005920), hsa-mir-215-5p (MIRT024500), hsa-mir-34a-5p (MIRT025258), hsa-mir-139-3p (MIRT038685), hsa-mir-30a-5p (MIRT028478), hsa-mir-136-5p (MIRT006867)

    Block miRNA regulation of human, mouse, rat MTDH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTDH (see all 210):
    hsa-miR-411* hsa-miR-579 hsa-miR-3938 hsa-miR-146a hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidMTDH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTDH
    Predesigned siRNA for gene silencing in human, mouse, rat MTDH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTDH

    Clone
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    OriGene clones in human, mouse for MTDH (see all 7)
    OriGene ORF clones in mouse, rat for MTDH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTDH (NM_178812)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTDH

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MTDH
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTDH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTDH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYRIC_HUMAN, Q86UE4: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
    membrane protein (By similarity). Cell junction, tight junction (By similarity). Nucleus, nucleolus (By
    similarity). Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during
    the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking
    the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane4
    cytosol2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16452207
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA19648967
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane ISS--

    MTDH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTDH About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    2Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    3Gastric cancer network 2
    Gastric cancer network 2
    4Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MTDH
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for MTDH
        Cell adhesion Tight junctions

    2 BioSystems Pathways for MTDH
        Gastric cancer network 2
    Validated targets of C-MYC transcriptional activation




    MTDH for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MTDH: 
              Liver Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for MTDH (Q86UE41, 3 ENSP000003382354) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927931, 3, ENSP000002623674EBI-1046588,EBI-81215 I2D: score=1 STRING: ENSP00000262367
    IL8P101453, ENSP000003065124I2D: score=1 STRING: ENSP00000306512
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    OTUD6BQ8N6M03, ENSP000002854204I2D: score=2 STRING: ENSP00000285420
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15927426
    GO:0010508positive regulation of autophagy IDA--
    GO:0031663lipopolysaccharide-mediated signaling pathway IMP19740331
    GO:0043066negative regulation of apoptotic process IDA17704808
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IDA16452207

    MTDH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTDH (LYRIC)

    2 Novoseek inferred chemical compound relationships for MTDH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agar 44.5 6 19940250 (1), 15927426 (1), 19633686 (1), 19304953 (1)
    glutamate 13.7 6 15927426 (2), 19770591 (2)



    MTDH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTDH gene: 
    NM_178812.3  

    Unigene Cluster for MTDH:

    Metadherin
    Hs.377155  [show with all ESTs]
    Unigene Representative Sequence: NM_178812
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336273(uc003yhz.3 uc010mbf.3) ENST00000519934 ENST00000522313
    ENST00000519293 ENST00000521933 ENST00000522104
    miRNA
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    Block miRNA regulation of human, mouse, rat MTDH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTDH (see all 210):
    hsa-miR-411* hsa-miR-579 hsa-miR-3938 hsa-miR-146a hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidMTDH 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MTDH
    Predesigned siRNA for gene silencing in human, mouse, rat MTDH
    Clone
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    OriGene ORF clones in mouse, rat for MTDH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTDH (NM_178812)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTDH
    Primer
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    OriGene qPCR primer pairs and template standards for MTDH
    OriGene qSTAR qPCR primer pairs in human, mouse for MTDH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTDH
      QuantiTect SYBR Green Assays in human, mouse, rat MTDH
      QuantiFast Probe-based Assays in human, mouse, rat MTDH

    Additional mRNA sequence: 

    AF411226.1 AF501310.1 AK000745.1 AK123083.1 AK308030.1 AL117594.1 AY082966.1 AY974040.1 
    BC001815.1 BC009324.2 BC014977.1 BC022825.1 BC023994.1 BC045642.1 

    Selected DOTS entries (see all 32):

    DT.97868107  DT.452696  DT.114634  DT.92463062  DT.95259727  DT.121491002  DT.121490997  DT.100830223 
    DT.100881571  DT.121491049  DT.100750198  DT.95259739  DT.100881573  DT.121490949  DT.121490958  DT.100881576 
    DT.121490954  DT.121490999  DT.121491022  DT.317999  DT.97806417  DT.100709738  DT.121490947  DT.121641383 

    Selected AceView cDNA sequences (see all 589):

    BE888553 BQ008391 CB162241 BQ549562 AA214518 AA648500 BM725072 AW241456 
    AY082966 BM354033 AI860548 BM667032 BG165164 BQ215420 BM854886 BM662963 
    AA064881 AU253373 BF476058 BC001815 BQ030087 AA064804 BU431420 NM_178812 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MTDH    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                            -                                       
    SP3:                                                                                    


    ECgene alternative splicing isoforms for MTDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MTDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAAGTTT
    MTDH Expression
    About this image


    MTDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    MTDH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTDH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377155

    UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
    Tissue specificity: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle,
    heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in
    various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme

        Pathway & Disease-focused RT2 Profiler PCR Array including MTDH: 
              Liver Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTDH
    OriGene qSTAR qPCR primer pairs in human, mouse for MTDH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTDH
    QuantiTect SYBR Green Assays in human, mouse, rat MTDH
    QuantiFast Probe-based Assays in human, mouse, rat MTDH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTDH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MTDH gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtdh1 , 5 metadherin1, 5 90.62(n)1
    91.19(a)1
      15 (13.98 cM)5
    671541  NM_026002.41  NP_080278.31 
     340826945 
    chicken
    (Gallus gallus)
    Aves MTDH1 metadherin 72.83(n)
    62.62(a)
      101751823  XM_004939973.1  XP_004940030.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    52(a)
    many → 1
    many → 1
    5(116041846-116042519)
    4(20473553-20503118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.251862 Xenopus laevis transcribed sequence with weak similarity more 73.79(n)    BU909155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtdha1 metadherin a 52.45(n)
    42.14(a)
      368910  NM_001007135.2  NP_001007136.2 


    ENSEMBL Gene Tree for MTDH (if available)
    TreeFam Gene Tree for MTDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTDH gene

    MTDH for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MTDH (see all 7)
    PGOHUM00000234237 PGOHUM00000256848 PGOHUM00000256849 PGOHUM00000256850 PGOHUM00000234619


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MTDH (see all 1704)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882444291,2
    --98654455(+) AGCACA/GATCTC 1 -- us2k10--------
    rs1161002781,2
    C,F--98654487(+) TCTGGG/TTTCAA 1 -- us2k11Minor allele frequency- T:0.19WA 118
    rs1170301871,2
    C,F--98654561(+) ATTATT/CGTAAT 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs117758831,2
    C,A,H--98654651(+) cgcggA/Ttcacg 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs25124451,2
    C,F,A,H--98654821(+) GAAATG/CTTATT 1 -- us2k1 tfbs315Minor allele frequency- C:0.43NS EA WA NA CSA 790
    rs1475835781,2
    C--98655151(+) AATAC-/AGAGTTT 1 -- us2k10--------
    rs1931644061,2
    --98655166(+) TATAGA/CAAAAT 1 -- us2k10--------
    rs24481651,2
    C,F,A,H--98655301(+) GTCAGG/AAGATC 1 -- us2k12Minor allele frequency- A:0.50NA WA 6
    rs1178193411,2
    F--98655454(+) GCAGTG/AAGCGG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs1499102711,2
    --98655458(+) TGAGCG/TGAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTDH (98656407 - 98742488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MTDH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526913CNV Loss19592680
    nsv6325CNV Loss18451855
    esv2752271CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing MTDH:
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing MTDH
    DNA2.0 Custom Variant and Variant Library Synthesis for MTDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610323    OMIM disorders: --

    Selected diseases for MTDH (see all 37):    
    About MalaCards
    acute hemorrhagic conjunctivitis    gallbladder adenocarcinoma    glioblastoma multiforme    conjunctivitis
    malignant glioma    oligodendroglioma    migraine    laryngeal squamous cell carcinoma
    diffuse large b-cell lymphoma    b-cell lymphomas    esophageal squamous cell carcinoma    peritonitis
    laryngitis    osteosarcoma    squamous cell carcinoma    neuroblastoma
    breast cancer    renal cell carcinoma    melanoma    prostate cancer


    MTDH for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for MTDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 62.6 11 15927426 (2), 18316612 (2), 20053777 (2)
    glioblastoma multiforme 52.6 2 16452207 (1)
    metastasis 51.8 19 19111877 (3), 19903854 (2), 15093543 (2), 19622726 (1) (see all 11)
    tumors 37.4 25 15927426 (4), 18519759 (3), 15093543 (3), 17397930 (1) (see all 12)
    breast cancer 30.2 26 18519759 (9), 19633686 (5), 15093543 (2), 19111877 (2) (see all 5)
    cancer 27.9 11 19903854 (3), 19622726 (2), 19940250 (2), 19304953 (1) (see all 5)
    melanoma 27.3 3 16452207 (1), 15927426 (1)
    breast carcinoma 20.9 1 15927426 (1)
    necrosis 16.5 6 19770591 (2), 17397930 (1), 16452207 (1), 19740331 (1) (see all 5)

    Genetic Association Database (GAD): MTDH
    Human Genome Epidemiology (HuGE) Navigator: MTDH (1 document)

    Export disorders for MTDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTDH gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with MTDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. (PubMed id 15093543)1, 2, 3, 9 Brown D.M. and Ruoslahti E. (Cancer Cell 2004)
    2. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PubMed id 16452207)1, 2, 9 Emdad L....Fisher P.B. (Cancer Res. 2006)
    3. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. (PubMed id 18316612)1, 2, 9 Sarkar D.... Fisher P.B. (Cancer Res. 2008)
    4. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. (PubMed id 15927426)1, 2, 9 Kang D.-C.... Fisher P.B. (Gene 2005)
    5. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. (PubMed id 19111877)1, 2, 9 Hu G.... Kang Y. (Cancer Cell 2009)
    6. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. (PubMed id 20802479)1, 4 Anttila V....Palotie A. (Nat. Genet. 2010)
    7. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. (PubMed id 18440304)1, 2 Ash S.C.... Britt D.E. (Biochem. Biophys. Res. Commun. 2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. (PubMed id 15383321)1, 2 Britt D.E.... Hixson D.C. (Exp. Cell Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 92140 HGNC: 29608 AceView: LYRIC Ensembl:ENSG00000147649 euGenes: HUgn92140
    ECgene: MTDH H-InvDB: MTDH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MTDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MTDH gene:
    Search GeneIP for patents involving MTDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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