Aliases for MTDH Gene
External Ids for MTDH Gene
Previous GeneCards Identifiers for MTDH Gene
GeneCards Summary for MTDH Gene
MTDH (Metadherin) is a Protein Coding gene. Diseases associated with MTDH include central nervous system disease and nervous system disease. Among its related pathways are Validated targets of C-MYC transcriptional activation and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding.
UniProtKB/Swiss-Prot for MTDH Gene
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.