Aliases for MTDH Gene
External Ids for MTDH Gene
Previous GeneCards Identifiers for MTDH Gene
GeneCards Summary for MTDH Gene
MTDH (Metadherin) is a Protein Coding gene. Among its related pathways are Adhesion and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include transcription coactivator activity and NF-kappaB binding.
UniProtKB/Swiss-Prot for MTDH Gene
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.