Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTDH Gene

Aliases for MTDH Gene

  • Metadherin 2 3 4
  • LYRIC 3 4 6
  • AEG1 3 4 6
  • Lysine-Rich CEACAM1 Co-Isolated Protein 3 4
  • Astrocyte Elevated Gene-1 Protein 3 4
  • Metastasis Adhesion Protein 3 4
  • Astrocyte Elevated Gene 1 2 3
  • 3D3/LYRIC 3 4
  • AEG-1 3 4
  • Protein LYRIC 3
  • LYRIC/3D3 3
  • 3D3 3

External Ids for MTDH Gene

Summaries for MTDH Gene

GeneCards Summary for MTDH Gene

MTDH (Metadherin) is a Protein Coding gene. Among its related pathways are Adhesion and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include transcription coactivator activity and NF-kappaB binding.

UniProtKB/Swiss-Prot for MTDH Gene

  • Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.

Gene Wiki entry for MTDH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTDH Gene

Genomics for MTDH Gene

Genomic Location for MTDH Gene

Start:
97,644,147 bp from pter
End:
97,730,260 bp from pter
Size:
86,114 bases
Orientation:
Plus strand

Genomic View for MTDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTDH Gene

Regulatory Elements for MTDH Gene

Proteins for MTDH Gene

  • Protein details for MTDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE4-LYRIC_HUMAN
    Recommended name:
    Protein LYRIC
    Protein Accession:
    Q86UE4
    Secondary Accessions:
    • Q05DH2
    • Q52QU9
    • Q6PK07
    • Q8TCX3

    Protein attributes for MTDH Gene

    Size:
    582 amino acids
    Molecular mass:
    63837 Da
    Quaternary structure:
    • Interacts with BCCIP, CREBBP/CBP and RELA/p65.
    Miscellaneous:
    • Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and the reciprocal effect is observed following overexpression

    Three dimensional structures from OCA and Proteopedia for MTDH Gene

neXtProt entry for MTDH Gene

Proteomics data for MTDH Gene at MOPED

Post-translational modifications for MTDH Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys107

Other Protein References for MTDH Gene

No data available for DME Specific Peptides for MTDH Gene

Domains for MTDH Gene

Protein Domains for MTDH Gene

ProtoNet:
genes like me logo Genes that share domains with MTDH: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MTDH Gene

Function for MTDH Gene

Molecular function for MTDH Gene

UniProtKB/Swiss-Prot Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
UniProtKB/Swiss-Prot Induction: By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes.

Gene Ontology (GO) - Molecular Function for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 18316612
GO:0003713 transcription coactivator activity IMP 18316612
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 18316612
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MTDH: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTDH Gene

Localization for MTDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTDH Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTDH Gene COMPARTMENTS Subcellular localization image for MTDH gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16452207
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 19648967
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with MTDH: view

Pathways for MTDH Gene

genes like me logo Genes that share pathways with MTDH: view

Pathways by source for MTDH Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for MTDH Gene
1 Cell Signaling Technology pathway for MTDH Gene

Gene Ontology (GO) - Biological Process for MTDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15927426
GO:0010508 positive regulation of autophagy IDA 21127263
GO:0031663 lipopolysaccharide-mediated signaling pathway IMP 19740331
GO:0043066 negative regulation of apoptotic process IDA 17704808
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 16452207
genes like me logo Genes that share ontologies with MTDH: view

Compounds for MTDH Gene

(2) Novoseek inferred chemical compound relationships for MTDH Gene

Compound -log(P) Hits PubMed IDs
agar 44.5 4
glutamate 13.7 4
genes like me logo Genes that share compounds with MTDH: view

Transcripts for MTDH Gene

Unigene Clusters for MTDH Gene

Metadherin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3:

Relevant External Links for MTDH Gene

GeneLoc Exon Structure for
MTDH
ECgene alternative splicing isoforms for
MTDH

Expression for MTDH Gene

mRNA expression in normal human tissues for MTDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTDH Gene

SOURCE GeneReport for Unigene cluster for MTDH Gene Hs.377155

mRNA Expression by UniProt/SwissProt for MTDH Gene

Q86UE4-LYRIC_HUMAN
Tissue specificity: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
genes like me logo Genes that share expressions with MTDH: view

Orthologs for MTDH Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTDH 36
  • 99.71 (n)
  • 99.48 (a)
MTDH 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTDH 36
  • 93.7 (n)
  • 92.78 (a)
MTDH 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTDH 36
  • 92.61 (n)
  • 90.72 (a)
MTDH 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtdh 36
  • 90.62 (n)
  • 91.19 (a)
Mtdh 16
Mtdh 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTDH 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTDH 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtdh 36
  • 90.3 (n)
  • 90.19 (a)
chicken
(Gallus gallus)
Aves MTDH 36
  • 72.83 (n)
  • 62.62 (a)
MTDH 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.25186 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75963 36
mtdh 36
  • 62.21 (n)
  • 55.81 (a)
zebrafish
(Danio rerio)
Actinopterygii mtdha 36
  • 52.45 (n)
  • 42.14 (a)
mtdha 37
  • 36 (a)
OneToMany
mtdhb 37
  • 35 (a)
OneToMany
Species with no ortholog for MTDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTDH Gene

ENSEMBL:
Gene Tree for MTDH (if available)
TreeFam:
Gene Tree for MTDH (if available)

Paralogs for MTDH Gene

genes like me logo Genes that share paralogs with MTDH: view

No data available for Paralogs for MTDH Gene

Variants for MTDH Gene

Sequence variations from dbSNP and Humsavar for MTDH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1311 -- 97,726,133(+) CAAAA(C/T)GGTTT utr-variant-3-prime
rs7754 -- 97,728,495(+) ATGTA(A/G)CTGCC utr-variant-3-prime
rs12247 -- 97,729,534(+) TTGTG(A/T)ATCTC utr-variant-3-prime
rs15041 -- 97,728,625(-) ACTTC(C/T)ATCTT utr-variant-3-prime
rs1045444 -- 97,729,477(+) gaaga(C/T)gagaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTDH Gene

Variant ID Type Subtype PubMed ID
esv2752271 CNV Gain 17911159
nsv6325 CNV Loss 18451855
nsv526913 CNV Loss 19592680

Relevant External Links for MTDH Gene

HapMap Linkage Disequilibrium report
MTDH

Disorders for MTDH Gene

(9) Novoseek inferred disease relationships for MTDH Gene

Disease -log(P) Hits PubMed IDs
malignant glioma 62.6 6
glioblastoma multiforme 52.6 1
metastasis 51.8 15
tumors 37.4 19
breast cancer 30.2 19

Relevant External Links for MTDH

Genetic Association Database (GAD)
MTDH
Human Genome Epidemiology (HuGE) Navigator
MTDH
genes like me logo Genes that share disorders with MTDH: view

No data available for UniProtKB/Swiss-Prot for MTDH Gene

Publications for MTDH Gene

  1. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. (PMID: 15093543) Brown D.M. … Ruoslahti E. (Cancer Cell 2004) 2 3 4 23
  2. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. (PMID: 15927426) Kang D.-C. … Fisher P.B. (Gene 2005) 3 4 23
  3. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PMID: 16452207) Emdad L. … Fisher P.B. (Cancer Res. 2006) 3 4 23
  4. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. (PMID: 18316612) Sarkar D. … Fisher P.B. (Cancer Res. 2008) 3 4 23
  5. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. (PMID: 19111877) Hu G. … Kang Y. (Cancer Cell 2009) 3 4 23

Products for MTDH Gene

Sources for MTDH Gene

Back to Top

Content