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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTDH Gene

protein-coding   GIFtS: 58
GCID: GC08P098658

Metadherin

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
metadherin1 2     Metastasis Adhesion Protein2 3
Metadherin3     3D3/LYRIC2 3
AEG12 3 5     AEG-12 3
LYRIC2 3 5     3D32
Astrocyte Elevated Gene-1 Protein2 3     LYRIC/3D32
Lysine-Rich CEACAM1 Co-Isolated Protein2 3     Protein LYRIC2

External Ids:    HGNC: 296081   Entrez Gene: 921402   Ensembl: ENSG000001476497   OMIM: 6103235   UniProtKB: Q86UE43   

Export aliases for MTDH gene to outside databases

Previous GC identifers: GC08P098726 GC08P093862


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTDH Gene: 
MTDH (metadherin) is a protein-coding gene. Diseases associated with MTDH include acute hemorrhagic conjunctivitis, and conjunctivitis, and among its related super-pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include transcription coactivator activity and NF-kappaB binding.

UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor
kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and
astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on
bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium.
Induces chemoresistance

Gene Wiki entry for MTDH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTDH gene promoter:
         GR   AP-1   ATF-2   Egr-4   MEF-2A   c-Jun   aMEF-2   GR-alpha   FOXO1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTDH promoter sequence
   Search SABiosciences Chromatin IP Primers for MTDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

MTDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTDH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P098658:  view genomic region     (about GC identifiers)

Start:
98,656,407 bp from pter      End:
98,742,488 bp from pter
Size:
86,082 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4 (See protein sequence)
Recommended Name: Protein LYRIC  
Size: 582 amino acids; 63837 Da
Subunit: Interacts with BCCIP, CREBBP/CBP and RELA/p65
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
membrane protein (By similarity). Cell junction, tight junction (By similarity). Nucleus, nucleolus (By
similarity). Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during
the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking
the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus
Miscellaneous: Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial
cells and the reciprocal effect is observed following overexpression
Caution: Was originally (PubMed:15093543) thought to be a type II membrane protein but this is inconsistent with
the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in
the lumen or extracellularly rather than in the cytoplasm
Secondary accessions: Q05DH2 Q52QU9 Q6PK07 Q8TCX3

Explore the universe of human proteins at neXtProt for MTDH: NX_Q86UE4

Explore proteomics data for MTDH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UE4

  • MTDH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTDH Protein Expression
    REFSEQ proteins: NP_848927.2  
    ENSEMBL proteins: 
     ENSP00000338235   ENSP00000428168   ENSP00000428703   ENSP00000429289   ENSP00000429642  

    Human Recombinant Protein Products for MTDH: 
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    Sino Biological Recombinant Protein for MTDH
    Sino Biological Cell Lysate for MTDH 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTDH 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16452207
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA19648967
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane ISS--

    MTDH for ontologies           About GeneDecksing



    MTDH Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MTDH 

    Assay Products for MTDH: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86UE4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYRIC_HUMAN, Q86UE4
    Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor
    kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and
    astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on
    bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium.
    Induces chemoresistance
    Induction: By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI18316612
    GO:0003713transcription coactivator activity IMP18316612
    GO:0005515protein binding IPI18316612
    GO:0051059NF-kappaB binding IPI16452207
         
    MTDH for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTDH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTDH 

    miRNA
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    miRTarBase miRNAs that target MTDH:
    hsa-mir-26a (MIRT005920)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTDH
    8/210 QIAGEN miScript miRNA Assays for microRNAs that regulate MTDH (see all 210):
    hsa-miR-411* hsa-miR-579 hsa-miR-3938 hsa-miR-146a hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidMTDH 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTDH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MTDH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    2Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    3Adhesion
    Adhesion
    4Gastric cancer network 2
    Gastric cancer network 2

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MTDH
        Cell adhesion Tight junctions


    1 Cell Signaling Technology (CST) Pathway for MTDH
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for MTDH
        Cell adhesion Tight junctions

    2 BioSystems Pathways for MTDH
        Gastric cancer network 2
    Validated targets of C-MYC transcriptional activation




    MTDH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/19 Interacting proteins for MTDH (Q86UE41, 3 ENSP000003382354) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927931, 3, ENSP000002623674EBI-1046588,EBI-81215 I2D: score=1 STRING: ENSP00000262367
    IL8P101453, ENSP000003065124I2D: score=1 STRING: ENSP00000306512
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    OTUD6BQ8N6M03, ENSP000002854204I2D: score=2 STRING: ENSP00000285420
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15927426
    GO:0010508positive regulation of autophagy IDA--
    GO:0031663lipopolysaccharide-mediated signaling pathway IMP19740331
    GO:0043066negative regulation of apoptotic process IDA17704808
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IDA16452207

    MTDH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTDH (LYRIC)

    2 Novoseek inferred chemical compound relationships for MTDH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agar 44.5 6 19940250 (1), 15927426 (1), 19633686 (1), 19304953 (1)
    glutamate 13.7 6 15927426 (2), 19770591 (2)

    Search CenterWatch for drugs/clinical trials and news about MTDH / LYRIC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTDH gene: 
    NM_178812.3  

    Unigene Cluster for MTDH:

    Metadherin
    Hs.377155  [show with all ESTs]
    Unigene Representative Sequence: NM_178812
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336273(uc003yhz.3 uc010mbf.3) ENST00000519934 ENST00000522313
    ENST00000519293 ENST00000521933 ENST00000522104

    miRNA
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    8/210 QIAGEN miScript miRNA Assays for microRNAs that regulate MTDH (see all 210):
    hsa-miR-411* hsa-miR-579 hsa-miR-3938 hsa-miR-146a hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidMTDH 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTDH
    Sirion Biotech Customized lentivirus for stable overexpression of MTDH 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTDH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTDH

    Additional mRNA sequence: 

    AF411226.1 AF501310.1 AK000745.1 AK123083.1 AK308030.1 AL117594.1 AY082966.1 AY974040.1 
    BC001815.1 BC009324.2 BC014977.1 BC022825.1 BC023994.1 BC045642.1 

    24/32 DOTS entries (see all 32):

    DT.97868107  DT.452696  DT.114634  DT.92463062  DT.95259727  DT.121491002  DT.121490997  DT.100830223 
    DT.100881571  DT.121491049  DT.100750198  DT.95259739  DT.100881573  DT.121490949  DT.121490958  DT.100881576 
    DT.121490954  DT.121490999  DT.121491022  DT.317999  DT.97806417  DT.100709738  DT.121490947  DT.121641383 

    24/589 AceView cDNA sequences (see all 589):

    AA620850 AA055442 AU253373 AA292657 BM511837 AA112884 BU169536 BQ549562 
    BQ774869 BC014977 AW241456 AY082966 AF501310 AI686385 AA844118 AA197167 
    BM725072 AA044887 H03449 AA765979 CB215625 BU431420 AI679643 BM475090 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MTDH    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                            -                                       
    SP3:                                                                                    


    ECgene alternative splicing isoforms for MTDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTDH expression in normal human tissues (normalized intensities)      MTDH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAAGTTT
    MTDH Expression
    About this image


    MTDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             lymphocytes   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See MTDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTDH

    SOURCE GeneReport for Unigene cluster: Hs.377155

    UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
    Tissue specificity: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle,
    heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in
    various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme

        SABiosciences Expression via Pathway-Focused PCR Array including MTDH: 
              Liver Cancer in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTDH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MTDH gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtdh1 , 5 metadherin1, 5 90.9(n)1
    91.54(a)1
      15 (13.98 cM)5
    671541  NM_026002.41  NP_080278.31 
     340826945 
    chicken
    (Gallus gallus)
    Aves MTDH6
    metadherin
    57(a)
    1 ↔ 1
    2(127057053-127088247)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    53(a)
    many → 1
    many → 1
    5(116041846-116042519)
    4(20473553-20503118)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.251862 Xenopus laevis transcribed sequence with weak similarity more 73.79(n)    BU909155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtdha1 metadherin a 55.37(n)
    45.45(a)
      368910  NM_001007135.2  NP_001007136.2 


    ENSEMBL Gene Tree for MTDH (if available)
    TreeFam Gene Tree for MTDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTDH gene

    MTDH for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for MTDH (see all 7)
    PGOHUM00000234237 PGOHUM00000256848 PGOHUM00000256849 PGOHUM00000256850 PGOHUM00000234619


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1704 SNPs in MTDH are shown (see all 1704)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882444291,2
    --98654455(+) AGCACA/GATCTC 1 -- us2k10--------
    rs1161002781,2
    C,F--98654487(+) TCTGGG/TTTCAA 1 -- us2k11Minor allele frequency- T:0.19WA 118
    rs1170301871,2
    C,F--98654561(+) ATTATT/CGTAAT 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs117758831,2
    C,A,H--98654651(+) cgcggA/Ttcacg 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs25124451,2
    C,F,A,H--98654821(+) GAAATG/CTTATT 1 -- us2k1 tfbs315Minor allele frequency- C:0.43NS EA WA NA CSA 790
    rs1475835781,2
    C--98655151(+) AATAC-/AGAGTTT 1 -- us2k10--------
    rs1931644061,2
    --98655166(+) TATAGA/CAAAAT 1 -- us2k10--------
    rs24481651,2
    C,F,A,H--98655301(+) GTCAGG/AAGATC 1 -- us2k12Minor allele frequency- A:0.50NA WA 6
    rs1178193411,2
    F--98655454(+) GCAGTG/AAGCGG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs1499102711,2
    --98655458(+) TGAGCG/TGAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTDH (98656407 - 98742488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MTDH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526913CNV Loss19592680
    nsv6325CNV Loss18451855
    esv2752271CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing MTDH:
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing MTDH
    DNA2.0 Custom Variant and Variant Library Synthesis for MTDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610323    OMIM disorders: --

    20/31 diseases for MTDH (see all 31):    About MalaCards
    acute hemorrhagic conjunctivitis    conjunctivitis    malignant glioma    oligodendroglioma
    prostate cancer, progression of    migraine    glioblastoma    esophageal squamous cell carcinoma
    diffuse large b-cell lymphoma    peritonitis    osteosarcoma    b-cell lymphomas
    ovarian cancer    renal cell carcinoma    esophagitis    prostate cancer
    squamous cell carcinoma    breast cancer    melanoma    neuroblastoma


    MTDH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for MTDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 62.6 11 15927426 (2), 18316612 (2), 20053777 (2)
    glioblastoma multiforme 52.6 2 16452207 (1)
    metastasis 51.8 19 19111877 (3), 19903854 (2), 15093543 (2), 19622726 (1) (see all 11)
    tumors 37.4 25 15927426 (4), 18519759 (3), 15093543 (3), 17397930 (1) (see all 12)
    breast cancer 30.2 26 18519759 (9), 19633686 (5), 15093543 (2), 19111877 (2) (see all 5)
    cancer 27.9 11 19903854 (3), 19622726 (2), 19940250 (2), 19304953 (1) (see all 5)
    melanoma 27.3 3 16452207 (1), 15927426 (1)
    breast carcinoma 20.9 1 15927426 (1)
    necrosis 16.5 6 19770591 (2), 17397930 (1), 16452207 (1), 19740331 (1) (see all 5)

    Genetic Association Database (GAD): MTDH
    Human Genome Epidemiology (HuGE) Navigator: MTDH (1 document)

    Export disorders for MTDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTDH gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with MTDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. (PubMed id 15093543)1, 2, 3, 9 Brown D.M. and Ruoslahti E. (2004)
    2. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PubMed id 16452207)1, 2, 9 Emdad L....Fisher P.B. (2006)
    3. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. (PubMed id 18316612)1, 2, 9 Sarkar D....Fisher P.B. (2008)
    4. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. (PubMed id 15927426)1, 2, 9 Kang D.-C.... Fisher P.B. (2005)
    5. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. (PubMed id 19111877)1, 2, 9 Hu G.... Kang Y. (2009)
    6. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. (PubMed id 20802479)1, 4 Anttila V....Palotie A. (2010)
    7. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. (PubMed id 18440304)1, 2 Ash S.C....Britt D.E. (2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. (PubMed id 15383321)1, 2 Britt D.E.... Hixson D.C. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92140 HGNC: 29608 AceView: LYRIC Ensembl:ENSG00000147649 euGenes: HUgn92140
    ECgene: MTDH H-InvDB: MTDH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTDH gene:
    Search GeneIP for patents involving MTDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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