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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTDH Gene

protein-coding   GIFtS: 54
GCID: GC08P098658

metadherin
 Explore 29 diseases affiliated with
MTDH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MTDH    

Aliases
for MTDH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metadherin3     Astrocyte Elevated Gene-1 Protein2 3
Metadherin3     Lysine-Rich CEACAM1 Co-Isolated Protein2 3
LYRIC1 2 3 5     Metastasis Adhesion Protein2 3
AEG-11 2 3     3D3/LYRIC2 3
AEG12 3 5     LYRIC/3D32
3D31 2     Protein LYRIC2

External Ids:    HGNC: 296081   Entrez Gene: 921402   Ensembl: ENSG000001476497   OMIM: 6103235   UniProtKB: Q86UE43   

Export aliases for MTDH gene to outside databases

Previous GC identifers: GC08P098726 GC08P093862


Summaries
for MTDH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B
(NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes
which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain
metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance

Gene Wiki entry for MTDH


Genomic Views
for MTDH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTDH gene promoter:
         GR   AP-1   ATF-2   Egr-4   MEF-2A   c-Jun   aMEF-2   GR-alpha   FOXO1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MTDH promoter sequence
   Search SABiosciences Chromatin IP Primers for MTDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

MTDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTDH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P098658:  view genomic region     (about GC identifiers)

Start:
 98,656,407 bp from pter      End:
 98,742,488 bp from pter
Size:
 86,082 bases      Orientation:
 plus strand

Proteins
for MTDH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4 (See protein sequence)
Recommended Name: Protein LYRIC  
Size: 582 amino acids; 63837 Da
Subunit: Interacts with BCCIP, CREBBP/CBP and RELA/p65
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
membrane protein (By similarity). Cell junction, tight junction (By similarity). Nucleus, nucleolus (By similarity).
Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of
the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain
(By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus
Miscellaneous: Knockdown significantly reduces the adhesion of cancer cells to lung microvascular endothelial cells and
the reciprocal effect is observed following overexpression
Caution: Was originally (PubMed:15093543) thought to be a type II membrane protein but this is inconsistent with the
results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen
or extracellularly rather than in the cytoplasm
Secondary accessions: Q05DH2 Q52QU9 Q6PK07 Q8TCX3

Explore the universe of human proteins at neXtProt for MTDH: NX_Q86UE4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UE4

    • MTDH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_848927.2  
    ENSEMBL proteins: 
     ENSP00000338235   ENSP00000428168   ENSP00000428703   ENSP00000429289   ENSP00000429642  

    Human Recombinant Protein Products: 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MTDH
    OriGene Protein Over-expression Lysate: MTDH
    OriGene Custom Protein Services for MTDH 
    GenScript Custom Purified and Recombinant Proteins Services for MTDH
    Novus Biologicals MTDH Protein
    Novus Biologicals MTDH Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTDH

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16452207
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA19648967
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane ISS--


    MTDH for ontologies           About GeneDecksing



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    ThermoFisher Antibody for MTDH

    Assay Products for MTDH: 
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    Uscn ELISAs and CLIAs for MTDH

    Protein Domains /
    Families
    for MTDH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86UE4


    Function
    for MTDH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
    Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B
    (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes
    which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain
    metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance
    Induction: By TNF (at protein level). By HIV-1 infection of primary fetal astrocytes

    miRNA
    Products:            		miRTarBase miRNAs that target MTDH:
    hsa-mir-26a (MIRT005920)

    OriGene 3'-UTR Clone: MTDH
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTDH
    8/210 QIAGEN miScript miRNA Assays for microRNAs that regulate MTDH (see all 210):
    hsa-miR-411* hsa-miR-579 hsa-miR-3938 hsa-miR-146a hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmid: MTDH 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTDH (see all 6)
    OriGene shRNA RFP: MTDH
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTDH

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MTDH

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTDH (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTDH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTDH (NM_178812)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTDH 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MTDH
    Search LifeMap BioReagents cell lines for MTDH

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTDH

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI18316612
    GO:0003713transcription coactivator activity IMP18316612
    GO:0005515protein binding IPI18316612
    GO:0051059NF-kappaB binding IPI16452207


    MTDH for ontologies           About GeneDecksing



    Pathways & Interactions
    for MTDH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    2Validated targets of C-MYC transcriptional activation
    		Validated targets of C-MYC transcriptional activation1.00
    3Adhesion
    		Adhesion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MTDH
        Cell adhesion Tight junctions


    1 Cell Signaling Technology (CST) Pathway for MTDH
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for MTDH
        Cell adhesion Tight junctions

    1 BioSystems Pathway for MTDH 
        Validated targets of C-MYC transcriptional activation



    MTDH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/19 Interacting proteins for MTDH (Q86UE41, 3 ENSP000003382354) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927931, 3, ENSP000002623674EBI-1046588,EBI-81215 I2D: score=1 STRING: ENSP00000262367
    IL8P101453, ENSP000003065124I2D: score=1 STRING: ENSP00000306512
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    OTUD6BQ8N6M03, ENSP000002854204I2D: score=2 STRING: ENSP00000285420
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15927426
    GO:0010508positive regulation of autophagy IDA--
    GO:0031663lipopolysaccharide-mediated signaling pathway IMP19740331
    GO:0043066negative regulation of apoptotic process IDA17704808
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IDA18316612


    MTDH for ontologies           About GeneDecksing



    Drugs & Compounds
    for MTDH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTDH
    2 Novoseek chemical compound relationships for MTDH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agar 44.5 6 19940250 (1), 15927426 (1), 19633686 (1), 19304953 (1)
    glutamate 13.7 6 15927426 (2), 19770591 (2)

    Search CenterWatch for drugs/clinical trials and news about MTDH / LYRIC 

    Transcripts
    for MTDH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MTDH gene: 
    NM_178812.3  

    Unigene Cluster for MTDH:

    Metadherin
    Hs.377155  [show with all ESTs]
    Unigene Representative Sequence: NM_178812
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336273(uc003yhz.3 uc010mbf.3) ENST00000519934 ENST00000522313
    ENST00000519293 ENST00000521933 ENST00000522104

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MTDH
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTDH
    8/210 QIAGEN miScript miRNA Assays for microRNAs that regulate MTDH (see all 210):
    hsa-miR-411* hsa-miR-579 hsa-miR-3938 hsa-miR-146a hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmid: MTDH 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTDH (see all 6)
    OriGene shRNA RFP: MTDH
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTDH
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTDH (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTDH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MTDH (NM_178812)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTDH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTDH 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTDH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTDH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTDH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTDH

    Additional cDNA sequence: 

    AF411226.1 AF501310.1 AK000745.1 AK123083.1 AK308030.1 AL117594.1 AY082966.1 AY974040.1 
    BC001815.1 BC009324.2 BC014977.1 BC022825.1 BC023994.1 BC045642.1 

    24/32 DOTS entries (see all 32):

    DT.97868107  DT.452696  DT.114634  DT.92463062  DT.95259727  DT.121491002  DT.121490997  DT.100830223 
    DT.100881571  DT.121491049  DT.100750198  DT.95259739  DT.100881573  DT.121490949  DT.121490958  DT.100881576 
    DT.121490954  DT.121490999  DT.121491022  DT.317999  DT.97806417  DT.100709738  DT.121490947  DT.121641383 

    24/589 AceView cDNA sequences (see all 589):

    AA262768 AI754495 BG434154 AI340213 AI961903 AW338693 BM068826 AA064881 
    AA876015 CB143812 AA197167 CB112343 AA481118 CD239967 AI523837 BQ271475 
    BU431420 BM452575 CF138090 BX498530 CB164319 AW150842 AA055442 AI380159 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MTDH    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                            -                                       
    SP3:                                                                                    


    ECgene alternative splicing isoforms for MTDH

    Expression
    for MTDH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGAAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MTDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTDH

    SOURCE GeneReport for Unigene cluster: Hs.377155

    UniProtKB/Swiss-Prot: LYRIC_HUMAN, Q86UE4
    Tissue specificity: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart,
    tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers
    including breast, brain, prostate, melanoma and glioblastoma multiforme

        SABiosciences Expression via Pathway-Focused PCR Array including MTDH: 
              Liver Cancer in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTDH
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTDH

    Orthologs
    for MTDH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MTDH gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mtdh1 , 5 metadherin1, 5 90.9(n)1
    91.54(a)1    		   15 (13.98 cM)5
    671541  NM_026002.41  NP_080278.31 
     340826945 
    chicken
    (Gallus gallus)    		 Aves MTDH6
    		 Uncharacterized protein
    		 58(a)
    		 1 ↔ 1
    		 2(132137538-132170015)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 55(a)
    53(a)
    		 many → 1
    many → 1
    		 5(116041846-116042519)
    4(20473553-20503118)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.251862 Xenopus laevis transcribed sequence with weak similarity more 73.79(n)    BU909155.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mtdha1 metadherin a 55.37(n)
    45.45(a)    		   368910  NM_001007135.2  NP_001007136.2 


    ENSEMBL Gene Tree for MTDH (if available)
    TreeFam Gene Tree for MTDH (if available) 

    Paralogs
    for MTDH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTDH gene

    MTDH for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for MTDH (see all 7)
    PGOHUM00000234237 PGOHUM00000256848 PGOHUM00000256849 PGOHUM00000256850 PGOHUM00000234619


    Genomic Variants
    for MTDH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1358 NCBI SNPs in MTDH are shown (see all 1358)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1882444291,2
    		--98654455(+) AGCACA/GATCTC 1 -- us2k10--------
    rs1161002781,2
    		C,F,--98654487(+) TCTGGG/TTTCAA 1 -- us2k11Minor allele frequency- T:0.19WA 118
    rs1170301871,2
    		C,F,--98654561(+) ATTATT/CGTAAT 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs117758831,2
    		C,A,H--98654651(+) cgcggA/Ttcacg 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs25124451,2
    		C,F,A,H,--98654821(+) GAAATG/CTTATT 1 -- us2k1 tfbs315Minor allele frequency- C:0.43NS EA WA NA CSA 790
    rs1475835781,2
    		C,--98655151(+) AATAC-/AGAGTTT 1 -- us2k10--------
    rs1931644061,2
    		--98655166(+) TATAGA/CAAAAT 1 -- us2k10--------
    rs24481651,2
    		C,F,A,H,--98655301(+) GTCAGG/AAGATC 1 -- us2k12Minor allele frequency- A:0.50NA WA 6
    rs1178193411,2
    		F,--98655454(+) GCAGTG/AAGCGG 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs1499102711,2
    		--98655458(+) TGAGCG/TGAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTDH (98656407 - 98742488 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MTDH
         1 CNV: 8611

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing MTDH:
    Breast Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTDH
    DNA2.0 Custom Variant and Variant Library Synthesis for MTDH

    Disorders / Diseases
    for MTDH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MTDH for disorders           About GeneDecksing

    OMIM gene information: 610323    OMIM disorders: --

    20/29 diseases for MTDH (see all 29):    About MalaCards
    acute hemorrhagic conjunctivitis    malignant glioma    esophageal squamous cell carcinoma    squamous cell carcinoma
    epithelial ovarian cancer    renal cell carcinoma    prostate cancer, progression of    ovarian cancer
    oligodendroglioma    carcinoma    prostate cancer    migraine
    breast cancer    conjunctivitis    endometrial cancer    glioblastoma
    liver cancer    hepatocellular carcinoma    ovarian carcinoma    esophagitis

    9 Novoseek disease relationships for MTDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 62.6 11 15927426 (2), 18316612 (2), 20053777 (2)
    glioblastoma multiforme 52.6 2 16452207 (1)
    metastasis 51.8 19 19111877 (3), 19903854 (2), 15093543 (2), 19622726 (1) (see all 11)
    tumors 37.4 25 15927426 (4), 18519759 (3), 15093543 (3), 17397930 (1) (see all 12)
    breast cancer 30.2 26 18519759 (9), 19633686 (5), 15093543 (2), 19111877 (2) (see all 5)
    cancer 27.9 11 19903854 (3), 19622726 (2), 19940250 (2), 19304953 (1) (see all 5)
    melanoma 27.3 3 16452207 (1), 15927426 (1)
    breast carcinoma 20.9 1 15927426 (1)
    necrosis 16.5 6 19770591 (2), 17397930 (1), 16452207 (1), 19740331 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: MTDH (1 document)

    Export disorders for MTDH gene to outside databases

    Publications
    for MTDH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTDH gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with MTDH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. (PubMed id 15093543)1, 2, 3, 9 Brown D.M. and Ruoslahti E. (2004)
    2. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. (PubMed id 16452207)1, 2, 9 Emdad L....Fisher P.B. (2006)
    3. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. (PubMed id 18316612)1, 2, 9 Sarkar D....Fisher P.B. (2008)
    4. Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1. (PubMed id 15927426)1, 2, 9 Kang D.-C.... Fisher P.B. (2005)
    5. MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. (PubMed id 19111877)1, 2, 9 Hu G.... Kang Y. (2009)
    6. LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. (PubMed id 18440304)1, 2 Ash S.C....Britt D.E. (2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. (PubMed id 15383321)1, 2 Britt D.E.... Hixson D.C. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. 3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. (PubMed id 14980505)1, 2 Sutherland H.G.E.... Bickmore W.A. (2004)

    External Searches for MTDH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MTDH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92140 HGNC: 29608 AceView: LYRIC Ensembl:ENSG00000147649 euGenes: HUgn92140
    ECgene: MTDH H-InvDB: MTDH

    Other Databases showing MTDH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MTDH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTDH Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MTDH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MTDH gene:
    Search GeneIP for patents involving MTDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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