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Aliases & Descriptions for MTCP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases C6.1B 3 OTTHUMP00000024241 2 OTTHUMP00000082776 2 P13MTCP1 1 , 2 , 3 p8MTCP1 3
Descriptions MTCP-1 type A 3 MTCP-1 type B1 3 Mature T-cell proliferation-1 type A 3 Mature T-cell proliferation-1 type B1 2 , 3 mature T-cell proliferation 1 2 mature T-cell proliferation 1 isoform p13 2
Search outside databases for aliases for MTCP1 genePrevious GC identifers: GC0XM148310 GC0XM150627 GC0XP9J0022 GC0XM152712
Summaries for MTCP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MTCP1 : This gene was identified by involvement in some t(X;14) translocations associated with matureT-cell proliferations. This region has a complex gene structure, with a common promoter and5' exon spliced to two different sets of 3' exons that encode two different proteins.This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This proteinmay be involved in leukemogenesis. [provided by RefSeq] UniProtKB/Swiss-Prot: MTCPB_HUMAN, P56278 Function : Enhances the phosphorylation and activation of AKT1 and AKT2
Gene Wiki entry for MTCP1
Genomic Location for MTCP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MTCP1 gene Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 MTCP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM153853:
(about GC identifiers )
Start:
153,943,080 bp from pter
End:
154,029,244 bp from pter
Size:
86,165 bases
Orientation:
minus strand
Proteins for MTCP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MTCPA_HUMAN, P56277 (See
protein sequence )Recommended Name: Protein p8 MTCP-1 Size : 68 amino acids; 7747 Da
Subcellular location : Mitochondrion
PDB structures from and Proteopedia : 1EI0 (3D)
 1HP8 (3D)
 2HP8 (3D)
 Alternative splicing : 2 isoforms : P56277-1 P56278-1
UniProtKB/Swiss-Prot: MTCPB_HUMAN, P56278 (See
protein sequence )Recommended Name: Protein p13 MTCP-1 Size : 107 amino acids; 12600 Da
Subunit : Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3
PDB structures from and Proteopedia : 1A1X (3D)
 1QTT (3D)
 1QTU (3D)
 
Secondary accessions : Q5HYP2Alternative splicing : 2 isoforms : P56278-1 P56277-1
REFSEQ proteins: NP_001018025.1 ENSEMBL proteins: ENSP00000329343 ENSP00000358488 ENSP00000355058 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IEA --
About this table Antibodies for MTCP1: Assays for MTCP1:
Protein
Domains/ Families for MTCP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P56277 Graphical View of Domain Structure for InterPro Entry P56278 ProtoNet protein and cluster: P56277
UniProtKB/Swiss-Prot: MTCPB_HUMAN, P56278 Similarity : Belongs to the TCL1 family
Gene Function for MTCP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014221 Applied Biosystems Silencer ® siRNAs for MTCP1 Sigma-Aldrich siRNA for MTCP1 Sigma-Aldrich shRNA for MTCP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001018024                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001018024                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001018024  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001018025 UniProtKB/Swiss-Prot: MTCPB_HUMAN, P56278 Function : Enhances the phosphorylation and activation of AKT1 and AKT2
Genatlas biochemistry entry for MTCP1 :mature T cell proliferation 1,altered in T cell prolymphocytic leukemia,likely 2 genes in head tohead orientation,also involved in rearrangement in rare forms of hemophilia Pathways & Interactions for MTCP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MTCP1 4 Interacting proteins for MTCP1 (ENSP00000355058 3 P56278 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
About this table
Drugs & Compounds for MTCP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MTCP1
Transcripts for MTCP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014221 Sigma-Aldrich siRNA for MTCP1 Sigma-Aldrich shRNA for MTCP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001018024 NM_001018025 NM_014221
REFSEQ mRNAs for MTCP1 gene: NM_001018025.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001018025
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001018024                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001018024                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001018024  
24/140 AceView cDNA sequences (see all 140
):AW518026 NM_014221 AI819276 W00551 BG183809 AA483835 AI583531 CR600926 BM562671 F27883 CA397733 AV652912 AA702563 AI806243 N76849 AA804650 BM990206 AA367037 AI589667 BQ435229 BX110834 CR613140 CR604905 AW665383
highest scoring ESTs for MTCP1 :AI798850 AJ713845 BC002600 BE314605 BE383807 BE905247 BF111928 BG575085 BI257681 BM740092 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000330425
ENST00000369476
ENST00000362018
Expression for MTCP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MTCP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MTCP1 1 / 2 / 3
12 probe-sets matching MTCP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --Expression variation in blood from EXPOLDB for MTCP1
UniProtKB/Swiss-Prot: MTCPA_HUMAN, P56277 Tissue specificity : Expressed in many tissues with a relatively high level in skeletal muscle
UniProtKB/Swiss-Prot: MTCPB_HUMAN, P56278 Tissue specificity : Not found at a significant level in any tissue
Orthologs for MTCP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MTCP1 gene from 5 species
About this table Species with no ortholog for MTCP1 ENSEMBL Gene Tree for MTCP1 Paralogs for MTCP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MTCP1 gene TCL1A 2
SNPs/Variants for MTCP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MTCP1 (up to first 250kb)
Disorders & Mutations for MTCP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300116 UniProtKB/Swiss-Prot: MTCPB_HUMAN, P56278
Overexpressed in T-cell leukemia bearing a t(X;14) translocation Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cellprolymphocytic leukemia
5 Novoseek disease relationships for MTCP1 gene
About this table 1 PharmGKB disease relationship for MTCP1 gene About this table Genatlas disease: MTCP1 prolymphocytic leukemia (T-PLL),with translocation t(X;14)(q28;q11) and breakpoint at MTCP1 locus
Medical News for MTCP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MTCP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/33 PubMed articles for MTCP1 gene (see all 33
): MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. (PubMed id 8361760) 2, 3, 4 Stern M.-H.... Kirsch I.R. (1993) Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP- 1 in T cell malignancies. (PubMed id 9520380) 1, 3, 4 Fu Z.Q.... Harrison R.W. (1998) Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. (PubMed id 8634440) 1, 2, 3 Madani A....Stern M.H. (1996) Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444) 1, 3, 4 Laine J....Noguchi M. (2002) Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. (PubMed id 10959629) 1, 3, 4 Guignard L....Roumestand C. (2000) The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986) 1, 3, 4 Laine J....Noguchi M. (2000) Solution structure of the recombinant human oncoprotein p13MTCP1. (PubMed id 9691281) 1, 2, 3 Yang Y.S....Roumestand C. (1998) Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. (PubMed id 9315101) 1, 3 Gritti C....Stern M.H. (1997) A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. (PubMed id 8152252) 1, 3 Thick J....Taylor A.M. (1994) The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice. (PubMed id 17136114) 3 Joiner M....Stern M.H. (2007)
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Genome Databases showing MTCP1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MTCP1
(According to HUGE )
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--
Specialized Databases showing MTCP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MTCP1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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