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MTCP1 Gene

protein-coding   GIFtS: 50
GCID: GC0XM154290

Mature T-Cell Proliferation 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mature T-Cell Proliferation 11 2     p8MTCP12
Mature T-Cell Proliferation-1 Type B12 3     Protein P13 MTCP-12
MTCP-1 Type B12 3     C6.1B3
P13MTCP12     p13MTCP13
Mature T-Cell Proliferation 1 Isoform P132     

External Ids:    HGNC: 74231   Entrez Gene: 45152   Ensembl: ENSG000002148277   OMIM: 3001165   UniProtKB: P562783   
ORGUL members:         

Export aliases for MTCP1 gene to outside databases

Previous GC identifers: GC0XM148310 GC0XM150627 GC0XP9J0022 GC0XM152712 GC0XM153853 GC0XM153946 GC0XM142838


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTCP1 Gene:
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell
proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two
different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein
that is a member of the TCL1 family. This protein may be involved in leukemogenesis. (provided by RefSeq, Mar
2009)

GeneCards Summary for MTCP1 Gene:
MTCP1 (mature T-cell proliferation 1) is a protein-coding gene. Diseases associated with MTCP1 include queensland tick typhus, and x-linked lymphoproliferative syndrome 1. An important paralog of this gene is TCL1A.

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

Gene Wiki entry for MTCP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MTCP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MTCP1 promoter sequence
   Search Chromatin IP Primers for MTCP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MTCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTCP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM154290:  view genomic region     (about GC identifiers)

Start:
154,289,897 bp from pter      End:
154,376,212 bp from pter
Size:
86,316 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278 (See protein sequence)
Recommended Name: Protein p13 MTCP-1  
Size: 107 amino acids; 12600 Da
Subunit: Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3
Caution: MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene
3 PDB 3D structures from and Proteopedia for MTCP1:
1A1X (3D)        1QTT (3D)        1QTU (3D)    
Secondary accessions: Q5HYP2
Alternative splicing: 2 isoforms:  P56278-1   P56277-1   (Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein)

Explore the universe of human proteins at neXtProt for MTCP1: NX_P56278

Explore proteomics data for MTCP1 at MOPED


See MTCP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001018025.1  
ENSEMBL proteins: 
 ENSP00000427132   ENSP00000358488   ENSP00000355058  

MTCP1 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for MTCP1
OriGene MassSpec for MTCP1
OriGene Custom Protein Services for MTCP1
GenScript Custom Purified and Recombinant Proteins Services for MTCP1
Novus Biologicals MTCP1 Proteins
Novus Biologicals MTCP1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for MTCP1

MTCP1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
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OriGene Custom Antibody Services for MTCP1
Novus Biologicals MTCP1 Antibodies
Abcam antibodies for MTCP1
Cloud-Clone Corp. Antibodies for MTCP1
Search ThermoFisher Antibodies for MTCP1
LSBio Antibodies in human, mouse, rat for MTCP1

MTCP1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for MTCP1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MTCP1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for MTCP1
Cloud-Clone Corp. CLIAs for MTCP1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004832 TCL1_MTCP1

Graphical View of Domain Structure for InterPro Entry P56278

ProtoNet protein and cluster: P56278

1 Blocks protein domain: IPB004832 TCL1/MTCP1 family

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Similarity: Belongs to the TCL1 family


MTCP1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MTCP1_HUMAN, P56278
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

     Genatlas biochemistry entry for MTCP1:
mature T cell proliferation 1,altered in T cell prolymphocytic leukemia,likely 2 genes in head to head
orientation,also involved in rearrangement in rare forms of hemophilia

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTCP1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTCP1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTCP1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTCP1

miRNA
Products:
    
miRTarBase miRNAs that target MTCP1:
hsa-mir-26b-5p (MIRT029913)

Block miRNA regulation of human, mouse, rat MTCP1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MTCP1 (see all 43):
hsa-miR-142-5p hsa-miR-4328 hsa-miR-3616-5p hsa-miR-200a hsa-miR-29a hsa-miR-624* hsa-miR-141 hsa-miR-1184
SwitchGear 3'UTR luciferase reporter plasmidMTCP1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for MTCP1
Predesigned siRNA for gene silencing in human, mouse, rat MTCP1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for MTCP1

Clone
Products:
     
OriGene clones in human, mouse for MTCP1 (see all 10)
OriGene ORF clones in mouse, rat for MTCP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MTCP1 (NM_001018025)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCP1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for MTCP1
Browse ESI BIO Cell Lines and PureStem Progenitors for MTCP1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCP1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
mitochondrion2
cytosol1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--

MTCP1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MTCP1 About    
See pathways by source

SuperPathContained pathways About
1PI3K-Akt signaling pathway
PI3K-Akt signaling pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for MTCP1):
    PI3K-Akt signaling pathway


MTCP1 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including MTCP1: 
          PI3K-AKT Signaling Pathway in human mouse rat

Interactions:

    GeneGlobe Interaction Network for MTCP1

Selected Interacting proteins for MTCP1 (P562782, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
AKT2P317513I2D: score=4 
AKT1P317493I2D: score=3 
EWSR1Q018443I2D: score=2 
GRK5P349473I2D: score=1 
--Q9BWA23, 2MINT-66837 I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008283cell proliferation TAS8361760

MTCP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MTCP1

1 Novoseek inferred chemical compound relationship for MTCP1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine 12.8 1 9405159 (1)



MTCP1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MTCP1 gene (2 alternative transcripts): 
NM_001018025.3  NM_014221.3  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000504061 ENST00000369476(uc004fmz.2) ENST00000482244 ENST00000476116
ENST00000362018
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat MTCP1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate MTCP1 (see all 43):
hsa-miR-142-5p hsa-miR-4328 hsa-miR-3616-5p hsa-miR-200a hsa-miR-29a hsa-miR-624* hsa-miR-141 hsa-miR-1184
SwitchGear 3'UTR luciferase reporter plasmidMTCP1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for MTCP1
Predesigned siRNA for gene silencing in human, mouse, rat MTCP1
Clone
Products:
     
OriGene clones in human, mouse for MTCP1 (see all 10)
OriGene ORF clones in mouse, rat for MTCP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: MTCP1 (NM_001018025)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCP1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCP1
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for MTCP1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTCP1
  QuantiTect SYBR Green Assays in human, mouse, rat MTCP1
  QuantiFast Probe-based Assays in human, mouse, rat MTCP1

Selected AceView cDNA sequences (see all 140):

BQ435229 AA804650 BM562671 AW665383 CR600926 AA746145 AA702563 H57713 
AA367037 AW518026 AI819276 AA744649 AI094565 AL555580 NM_014221 AI583531 
AI806243 CR604905 N76849 F27883 AV652912 CR613140 BC002600 BM990206 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MTCP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MTCP1 Expression
About this image

MTCP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MTCP1 Protein Expression

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Tissue specificity: Not found at a significant level in any tissue

    Pathway & Disease-focused RT2 Profiler PCR Array including MTCP1: 
          PI3K-AKT Signaling Pathway in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for MTCP1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTCP1
QuantiTect SYBR Green Assays in human, mouse, rat MTCP1
QuantiFast Probe-based Assays in human, mouse, rat MTCP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MTCP1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mtcp15 mature T cell proliferation 1   --   X (38.22 cM) 75404846 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
59(a)
1 → many
GL343528.1(421305-421616)


ENSEMBL Gene Tree for MTCP1 (if available)
TreeFam Gene Tree for MTCP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MTCP1 gene
TCL1A2  TCL1B2  
2 SIMAP similar genes for MTCP1 using alignment to 1 protein entry:     MTCP1_HUMAN:
TCL1A    TCL1B

MTCP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MTCP1 (see all 76)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1921476711,2
--154160594(+) ATTGTC/TATTTC 1 -- int10--------
rs1437390411,2
F--154161009(+) TCTGTA/GTCTCA 1 -- int11Minor allele frequency- G:0.00NA 4466
rs2022158821,2
C--154161095(+) TTTTTC/TCCATA 1 -- ut310--------
rs1833537821,2
C--154161100(+) TCCATA/GAAGAC 1 -- ut310--------
rs1878496561,2
--154161623(+) CTTTAC/TAAGTA 1 -- ut310--------
rs2021904861,2
--154162429(+) CCTGG-/AAAAAA 1 -- int10--------
rs1916187491,2
--154162478(+) CAAAGA/GGGGGG 1 -- int10--------
rs2014094951,2
--154162678(+) CGAGAC/GTTGTT 2 N K mis10--------
rs2006221081,2
--154162940(+) TTCCAC/GGACGG 2 L V mis10--------
rs1844412031,2
--154163215(+) CTAAAC/TAGAAC 1 -- int10--------

HapMap Linkage Disequilibrium report for MTCP1 (154289897 - 154376212 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MTCP1:    About this table    
Variant IDTypeSubtypePubMed ID
esv29972CNV Gain17803354
esv33784CNV Gain+Loss17666407

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MTCP1
DNA2.0 Custom Variant and Variant Library Synthesis for MTCP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300116    OMIM disorders: --

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
  • Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell
    prolymphocytic leukemia

  • 17 diseases for MTCP1:    
    About MalaCards
    queensland tick typhus    x-linked lymphoproliferative syndrome 1    lymphoproliferative disease, x-linked    lymphoproliferative syndrome 1
    african tick-bite fever    typhus    prolymphocytic leukemia    t-cell prolymphocytic leukemia
    ataxia telangiectasia    hemophilia    ataxia    t-cell leukemia
    leukemia    multiple myeloma    myeloma    prostate cancer
    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for MTCP1:
    Queensland tick typhus     Prolymphocytic leukemia     African tick-bite fever

    MTCP1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for MTCP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia prolymphocytic 94.9 6 9520380 (1), 9691281 (1), 10959629 (1), 11679718 (1) (see all 6)
    leukemia t-cell 75.3 3 8634440 (1), 9519406 (1)
    ataxia telangiectasia 60.6 1 8152252 (1)
    leukemia 44.5 1 9691281 (1)
    tumors 0 1 9315101 (1)

    Genatlas disease: MTCP1
    prolymphocytic leukemia (T-PLL),with translocation t(X;14)(q28;q11) and breakpoint at MTCP1 locus

    Genetic Association Database (GAD): MTCP1
    Human Genome Epidemiology (HuGE) Navigator: MTCP1 (4 documents)

    Export disorders for MTCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTCP1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MTCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. (PubMed id 8361760)1, 2, 3 Stern M.-H.... Kirsch I.R. (Oncogene 1993)
    2. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP- 1 in T cell malignancies. (PubMed id 9520380)1, 2, 9 Fu Z.Q.... Harrison R.W. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. (PubMed id 8634440)1, 3, 9 Madani A....Stern M.H. (Blood 1996)
    4. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (J. Biol. Chem. 2002)
    5. Backbone dynamics and solution structure refinement of the 15N- labeled human oncogenic protein p13MTCP1: comparison with X-ray data. (PubMed id 10959629)1, 2, 9 Guignard L.... Roumestand C. (J. Biomol. NMR 2000)
    6. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2, 9 Laine J.... Noguchi M. (Mol. Cell 2000)
    7. Solution structure of the recombinant human oncoprotein p13MTCP1. (PubMed id 9691281)1, 3, 9 Yang Y.S....Roumestand C. (J. Biomol. NMR 1998)
    8. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    9. Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. (PubMed id 9315101)1, 9 Gritti C....Stern M.H. (Oncogene 1997)
    10. A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. (PubMed id 8152252)1, 9 Thick J....Taylor A.M. (Leukemia 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4515 HGNC: 7423 AceView: MTCP1 Ensembl:ENSG00000214827 euGenes: HUgn4515
    ECgene: MTCP1 Kegg: 4515 H-InvDB: MTCP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTCP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTCP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTCP1 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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