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Aliases for MTCP1 Gene

Aliases for MTCP1 Gene

  • Mature T-Cell Proliferation 1 2 3 5
  • Mature T-Cell Proliferation-1 Type B1 3 4
  • MTCP-1 Type B1 3 4
  • P13MTCP1 3 4
  • Mature T-Cell Proliferation 1 Isoform P13 3
  • Protein P13 MTCP-1 3
  • P8MTCP1 3
  • C6.1B 4

External Ids for MTCP1 Gene

Previous GeneCards Identifiers for MTCP1 Gene

  • GC0XM148310
  • GC0XM150627
  • GC0XP9J0022
  • GC0XM152712
  • GC0XM153853
  • GC0XM153946
  • GC0XM154290
  • GC0XM142838

Summaries for MTCP1 Gene

Entrez Gene Summary for MTCP1 Gene

  • This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009]

GeneCards Summary for MTCP1 Gene

MTCP1 (Mature T-Cell Proliferation 1) is a Protein Coding gene. Diseases associated with MTCP1 include Prolymphocytic Leukemia and T-Cell Prolymphocytic Leukemia. Among its related pathways are PI3K-Akt signaling pathway. An important paralog of this gene is TCL1A.

UniProtKB/Swiss-Prot for MTCP1 Gene

  • Enhances the phosphorylation and activation of AKT1 and AKT2.

Gene Wiki entry for MTCP1 Gene

Additional gene information for MTCP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCP1 Gene

Genomics for MTCP1 Gene

Regulatory Elements for MTCP1 Gene

Enhancers for MTCP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH154917 1 Ensembl ENCODE 12 +229.7 229673 0 CTCF ZNF654 SP3 RB1 TRIM22 REST ZNF2 RAD21 ZNF217 CC2D1A BRCC3 CMC4 MTCP1 EEF1A1P31 ENSG00000224069
GH0XH155049 0.6 Ensembl 12.4 +98.7 98737 0 SCRT1 CTCF ZNF654 SCRT2 ZNF143 RAD21 F8A1 BRCC3 CMC4 MTCP1 F8
GH0XH155242 0.5 Ensembl 11.6 -94.6 -94648 0 SCRT1 SCRT2 ATF7 SPI1 MTCP1 RAB39B ENSG00000224978
GH0XH154544 1 ENCODE 3.8 +601.2 601150 4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ELK1 ATF7 RUNX3 SP3 SNORA56 HCFC1 DKC1 IKBKG FAM3A MTCP1 G6PD
GH0XH155137 0.3 FANTOM5 0.4 +10.7 10708 0 ENSG00000235991 MTCP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTCP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTCP1 Gene

Chromosome:
X
Start:
155,061,622 bp from pter
End:
155,147,937 bp from pter
Size:
86,316 bases
Orientation:
Minus strand

Genomic View for MTCP1 Gene

Genes around MTCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCP1 Gene

Proteins for MTCP1 Gene

  • Protein details for MTCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56278-MTCP1_HUMAN
    Recommended name:
    Protein p13 MTCP-1
    Protein Accession:
    P56278
    Secondary Accessions:
    • Q5HYP2

    Protein attributes for MTCP1 Gene

    Size:
    107 amino acids
    Molecular mass:
    12600 Da
    Quaternary structure:
    • Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.

    Three dimensional structures from OCA and Proteopedia for MTCP1 Gene

    Alternative splice isoforms for MTCP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTCP1 Gene

Post-translational modifications for MTCP1 Gene

No Post-translational modifications

Other Protein References for MTCP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTCP1 Gene

Domains & Families for MTCP1 Gene

Gene Families for MTCP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for MTCP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MTCP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56278

UniProtKB/Swiss-Prot:

MTCP1_HUMAN :
  • Belongs to the TCL1 family.
Family:
  • Belongs to the TCL1 family.
genes like me logo Genes that share domains with MTCP1: view

Function for MTCP1 Gene

Molecular function for MTCP1 Gene

GENATLAS Biochemistry:
mature T cell proliferation 1,altered in T cell prolymphocytic leukemia,likely 2 genes in head to head orientation,also involved in rearrangement in rare forms of hemophilia
UniProtKB/Swiss-Prot Function:
Enhances the phosphorylation and activation of AKT1 and AKT2.

Gene Ontology (GO) - Molecular Function for MTCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 10983986
GO:0043539 protein serine/threonine kinase activator activity IDA 10983986
genes like me logo Genes that share ontologies with MTCP1: view

Phenotypes for MTCP1 Gene

GenomeRNAi human phenotypes for MTCP1:
genes like me logo Genes that share phenotypes with MTCP1: view

Animal Model Products

CRISPR Products

miRNA for MTCP1 Gene

miRTarBase miRNAs that target MTCP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTCP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTCP1 Gene

Localization for MTCP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTCP1 gene
Compartment Confidence
extracellular 3
mitochondrion 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0043234 protein complex IDA 10983986
genes like me logo Genes that share ontologies with MTCP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MTCP1 Gene

Pathways & Interactions for MTCP1 Gene

SuperPathways for MTCP1 Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with MTCP1: view

Pathways by source for MTCP1 Gene

1 KEGG pathway for MTCP1 Gene

SIGNOR curated interactions for MTCP1 Gene

Activates:

Gene Ontology (GO) - Biological Process for MTCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 8361760
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 10983986
GO:0071902 positive regulation of protein serine/threonine kinase activity IDA 10983986
genes like me logo Genes that share ontologies with MTCP1: view

Drugs & Compounds for MTCP1 Gene

(1) Drugs for MTCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTCP1: view

Transcripts for MTCP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTCP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MTCP1 Gene

No ASD Table

Relevant External Links for MTCP1 Gene

GeneLoc Exon Structure for
MTCP1
ECgene alternative splicing isoforms for
MTCP1

Expression for MTCP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTCP1 Gene

Protein differential expression in normal tissues from HIPED for MTCP1 Gene

This gene is overexpressed in Fetal gut (28.7), NK cells (11.5), Ovary (8.9), Retina (7.8), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTCP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MTCP1 Gene:

MTCP1

mRNA Expression by UniProt/SwissProt for MTCP1 Gene:

P56278-MTCP1_HUMAN
Tissue specificity: Not found at a significant level in any tissue.

Evidence on tissue expression from TISSUES for MTCP1 Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with MTCP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTCP1 Gene

Orthologs for MTCP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTCP1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia MTCP1 33 34
  • 98.13 (n)
mouse
(Mus musculus)
Mammalia Mtcp1 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMC4 33 34
  • 93.15 (n)
oppossum
(Monodelphis domestica)
Mammalia MTCP1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTCP1 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
Species where no ortholog for MTCP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MTCP1 Gene

ENSEMBL:
Gene Tree for MTCP1 (if available)
TreeFam:
Gene Tree for MTCP1 (if available)

Paralogs for MTCP1 Gene

Paralogs for MTCP1 Gene

(2) SIMAP similar genes for MTCP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTCP1: view

Variants for MTCP1 Gene

Sequence variations from dbSNP and Humsavar for MTCP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs869312530 Likely benign 155,071,734(+) AGGGC(C/T)GCGGA intron-variant, upstream-variant-2KB
rs1000285506 -- 155,070,923(+) GAAAT(A/G)AAACA upstream-variant-2KB, utr-variant-5-prime
rs1003621099 -- 155,064,347(+) CAGAA(G/T)AAACC intron-variant, utr-variant-3-prime
rs1003913027 -- 155,064,867(+) CTCTA(A/C)ATACT intron-variant, utr-variant-3-prime
rs1004271514 -- 155,065,139(+) TTCTA(C/T)GGCAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTCP1 Gene

Variant ID Type Subtype PubMed ID
esv29972 CNV gain 17803354
esv33784 CNV gain+loss 17666407

Variation tolerance for MTCP1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTCP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCP1 Gene

Disorders for MTCP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MTCP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prolymphocytic leukemia
  • leukemia prolymphocytic
t-cell prolymphocytic leukemia
  • leukemia, t-cell, chronic
queensland tick typhus
  • australian tick typhus
- elite association - COSMIC cancer census association via MalaCards
Search MTCP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MTCP1_HUMAN
  • Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.

Genatlas disease for MTCP1 Gene

prolymphocytic leukemia (T-PLL),with translocation t(X;14)(q28;q11) and breakpoint at MTCP1 locus

Relevant External Links for MTCP1

Genetic Association Database (GAD)
MTCP1
Human Genome Epidemiology (HuGE) Navigator
MTCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTCP1
genes like me logo Genes that share disorders with MTCP1: view

Publications for MTCP1 Gene

  1. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J … Noguchi M (The Journal of biological chemistry 2002) 3 4 22 60
  2. The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J … Noguchi M (Molecular cell 2000) 3 4 22 60
  3. Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. (PMID: 10959629) Guignard L … Roumestand C (Journal of biomolecular NMR 2000) 3 4 22 60
  4. Solution structure of the recombinant human oncoprotein p13MTCP1. (PMID: 9691281) Yang YS … Roumestand C (Journal of biomolecular NMR 1998) 2 3 22 60
  5. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. (PMID: 9520380) Fu ZQ … Harrison RW (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 60

Products for MTCP1 Gene

Sources for MTCP1 Gene

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