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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTCP1 Gene

protein-coding   GIFtS: 46
GCID: GC0XM154290

mature T-cell proliferation 1

 Explore 11 diseases affiliated with
MTCP1 via our new
 Human Malady Compendium 
Biological research products
for MTCP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mature T-Cell Proliferation 11 2     Mature T-Cell Proliferation 1 Isoform P132
P13MTCP11 2     Protein P13 MTCP-12
P8MTCP11     C6.1B3
Mature T-Cell Proliferation-1 Type B12 3     P13MTCP11 2
MTCP-1 Type B12 3     

External Ids:    HGNC: 74231   Entrez Gene: 45152   Ensembl: ENSG000002148277   OMIM: 3001165   UniProtKB: P562783   

Export aliases for MTCP1 gene to outside databases

Previous GC identifers: GC0XM148310 GC0XM150627 GC0XP9J0022 GC0XM152712 GC0XM153853 GC0XM153946 GC0XM142838


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTCP1:
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations.
This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons
that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1
family. This protein may be involved in leukemogenesis. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

Gene Wiki entry for MTCP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MTCP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MTCP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTCP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MTCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTCP1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM154290:  view genomic region     (about GC identifiers)

Start:
154,289,897 bp from pter      End:
154,376,212 bp from pter
Size:
86,316 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278 (See protein sequence)
Recommended Name: Protein p13 MTCP-1  
Size: 107 amino acids; 12600 Da
Subunit: Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3
Caution: MTCP1 and MTCP1NB are transcribed from the same promoter and could be considered the same gene
3 PDB 3D structures from and Proteopedia for MTCP1:
1A1X (3D)        1QTT (3D)        1QTU (3D)    
Secondary accessions: Q5HYP2
Alternative splicing: 2 isoforms:  P56278-1   P56277-1   (Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein)

Explore the universe of human proteins at neXtProt for MTCP1: NX_P56278

MTCP1 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001018025.1  
ENSEMBL proteins: 
 ENSP00000427132   ENSP00000358488   ENSP00000355058  

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Uscn Proteins for MTCP1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--


MTCP1 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MTCP1 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR004832 TCL1_MTCP1

Graphical View of Domain Structure for InterPro Entry P56278

ProtoNet protein and cluster: P56278

1 Blocks protein family: IPB004832 TCL1/MTCP1 family

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Similarity: Belongs to the TCL1 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Function: Enhances the phosphorylation and activation of AKT1 and AKT2

     Genatlas biochemistry entry for MTCP1:
mature T cell proliferation 1,altered in T cell prolymphocytic leukemia,likely 2 genes in head to head orientation,also
involved in rearrangement in rare forms of hemophilia

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SwitchGear 3'UTR luciferase reporter plasmidMTCP1 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTCP1

5/7 Interacting proteins for MTCP1 (P562782, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
AKT2P317513I2D: score=4 
AKT1P317493I2D: score=3 
EWSR1Q018443I2D: score=2 
GRK5P349473I2D: score=1 
--Q9BWA23, 2MINT-66837 I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008283cell proliferation TAS8361760


MTCP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MTCP1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MTCP1
1 Novoseek chemical compound relationship for MTCP1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine 12.8 1 9405159 (1)

Search CenterWatch for drugs/clinical trials and news about MTCP1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MTCP1 gene (2 alternative transcripts): 
NM_001018025.3  NM_014221.3  

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000504061 ENST00000369476(uc004fmz.2) ENST00000482244 ENST00000476116
ENST00000362018

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8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate MTCP1 (see all 43):
hsa-miR-142-5p hsa-miR-4328 hsa-miR-3616-5p hsa-miR-200a hsa-miR-29a hsa-miR-624* hsa-miR-141 hsa-miR-1184
SwitchGear 3'UTR luciferase reporter plasmidMTCP1 3' UTR sequence
Inhib. RNA
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Clone
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24/140 AceView cDNA sequences (see all 140):

BF111928 W00551 AI819276 AA483835 AL555580 BM562671 CA397733 CR600926 
BG183809 AI589667 AW665383 AI055841 AA367037 CR613140 BX110834 AA804650 
BQ435229 BM990206 AA746145 AA702563 NM_014221 AV652912 AI583531 AI806243 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MTCP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
Genevestigator expression for MTCP1

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
Tissue specificity: Not found at a significant level in any tissue

    SABiosciences Expression via Pathway-Focused PCR Array including MTCP1: 
          PI3K-AKT Signaling Pathway in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTCP1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MTCP1 gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
61(a)
1 → many
4(2164580-2165779)
lizard
(Anolis carolinensis)
Reptilia --
--
59(a)
1 → many
GL343528.1(421305-421616)


ENSEMBL Gene Tree for MTCP1 (if available)
TreeFam Gene Tree for MTCP1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MTCP1 gene
TCL1A2  TCL1B2  
2 SIMAP similar genes for MTCP1 using alignment to 1 protein entry:     MTCP1_HUMAN:
TCL1A    TCL1B

MTCP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/48 NCBI SNPs in MTCP1 are shown (see all 48    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1921476711,2
--154291843(+) ATTGTC/TATTTC 2 -- int10--------
rs2022158821,2
--154292344(+) TTTTTC/TCCATA 2 -- int1 ut310--------
rs1833537821,2
--154292349(+) TCCATA/GAAGAC 2 -- int1 ut310--------
rs1878496561,2
--154292872(+) CTTTAC/TAAGTA 2 -- int1 ut310--------
rs2021904861,2
--154293678(+) CCTGG-/AAAAAA 2 -- int10--------
rs1916187491,2
--154293727(+) CAAAGA/GGGGGG 2 -- int10--------
rs2014094951,2
--154293927(+) CGAGAC/GTTGTT 3 N K int1 mis10--------
rs2006221081,2
--154294189(+) TTCCAC/GGACGG 3 L V int1 mis10--------
rs1844412031,2
--154294464(+) CTAAAC/TAGAAC 2 -- int10--------
rs1415734201,2
--154294717(+) GGCAGA/GAAGGC 2 -- int10--------

HapMap Linkage Disequilibrium report for MTCP1 (154289897 - 154376212 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MTCP1
     1 CNV: 23331

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MTCP1 for disorders           About GeneDecksing

OMIM gene information: 300116    OMIM disorders: --

UniProtKB/Swiss-Prot: MTCP1_HUMAN, P56278
  • Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic
  • leukemia

    11 diseases for MTCP1:    About MalaCards
    african tick-bite fever    queensland tick typhus    prolymphocytic leukemia    ataxia telangiectasia
    t-cell prolymphocytic leukemia    typhus    hemophilia    leukemia
    ataxia    t-cell leukemia    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for MTCP1:
    Queensland tick typhus     Prolymphocytic leukemia     African tick-bite fever

    5 Novoseek disease relationships for MTCP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia prolymphocytic 94.9 6 9520380 (1), 9691281 (1), 10959629 (1), 11679718 (1) (see all 6)
    leukemia t-cell 75.3 3 8634440 (1), 9519406 (1)
    ataxia telangiectasia 60.6 1 8152252 (1)
    leukemia 44.5 1 9691281 (1)
    tumors 0 1 9315101 (1)

    Genatlas disease: MTCP1
    prolymphocytic leukemia (T-PLL),with translocation t(X;14)(q28;q11) and breakpoint at MTCP1 locus

    Human Genome Epidemiology (HuGE) Navigator: MTCP1 (4 documents)

    Export disorders for MTCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTCP1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MTCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. (PubMed id 8361760)1, 2, 3 Stern M.-H.... Kirsch I.R. (1993)
    2. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP- 1 in T cell malignancies. (PubMed id 9520380)1, 2, 9 Fu Z.Q.... Harrison R.W. (1998)
    3. Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. (PubMed id 8634440)1, 3, 9 Madani A....Stern M.H. (1996)
    4. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PubMed id 11707444)1, 2, 9 Laine J.... Noguchi M. (2002)
    5. Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. (PubMed id 10959629)1, 2, 9 Guignard L....Roumestand C. (2000)
    6. The protooncogene TCL1 is an Akt kinase coactivator. (PubMed id 10983986)1, 2, 9 Laine J....Noguchi M. (2000)
    7. Solution structure of the recombinant human oncoprotein p13MTCP1. (PubMed id 9691281)1, 3, 9 Yang Y.S....Roumestand C. (1998)
    8. Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. (PubMed id 9315101)1, 9 Gritti C....Stern M.H. (1997)
    9. A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. (PubMed id 8152252)1, 9 Thick J....Taylor A.M. (1994)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4515 HGNC: 7423 AceView: MTCP1 Ensembl:ENSG00000214827 euGenes: HUgn4515
    ECgene: MTCP1 H-InvDB: MTCP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTCP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTCP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTCP1 gene:
    Search GeneIP for patents involving MTCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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