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Aliases for MTCL1 Gene

Aliases for MTCL1 Gene

  • Microtubule Crosslinking Factor 1 2 3 5
  • SOGA Family Member 2 2 3 4
  • KIAA0802 2 3 4
  • Coiled-Coil Domain-Containing Protein 165 3 4
  • Coiled-Coil Domain Containing 165 2 3
  • PAR-1-Interacting Protein 3 4
  • CCDC165 3 4
  • SOGA2 3 4
  • Microtubule Cross-Linking Factor 1 3

External Ids for MTCL1 Gene

Previous HGNC Symbols for MTCL1 Gene

  • KIAA0802
  • CCDC165
  • SOGA2

Summaries for MTCL1 Gene

GeneCards Summary for MTCL1 Gene

MTCL1 (Microtubule Crosslinking Factor 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and microtubule binding. An important paralog of this gene is SOGA1.

UniProtKB/Swiss-Prot for MTCL1 Gene

  • Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells.

Gene Wiki entry for MTCL1 Gene

Additional gene information for MTCL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCL1 Gene

Genomics for MTCL1 Gene

Regulatory Elements for MTCL1 Gene

Enhancers for MTCL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H008792 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +92.2 92244 10 ELF3 TBP FOXA2 SIN3A BRCA1 RAD21 RARA RFX5 GLIS2 SMARCC2 MTCL1 ENSG00000273368 ENSG00000272788 PIR49588
GH18H008703 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16 +1.0 972 6 HDGF SIN3A FEZF1 ZNF2 GLIS2 KLF7 ATF7 SP3 REST PPARG MTCL1 ENSG00000266708 ANKRD12 GACAT2
GH18H008728 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +25.0 24982 3 PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 TCF12 GLIS2 CBX5 GATA2 MTCL1 ENSG00000252319 PIR49588
GH18H009015 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +311.8 311754 3 HDGF PKNOX1 ATF1 ARNT ZNF766 CBX5 GATA2 ELK1 ZNF143 FOS ENSG00000266708 ANKRD12 MTCL1 RPS4XP19 PIR38562
GH18H008986 1.2 Ensembl ENCODE dbSUPER 17.2 +282.1 282078 1 CTCF HINFP CEBPG RAD21 CC2D1A CTBP1 POLR2A SMC3 ZNF143 ZNF654 MTCL1 RPS4XP19 PIR38562
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTCL1 on UCSC Golden Path with GeneCards custom track

Promoters for MTCL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000100409 622 3201 HDGF SIN3A FEZF1 ZNF2 GLIS2 KLF7 ATF7 SP3 REST SMARCB1

Genomic Location for MTCL1 Gene

Chromosome:
18
Start:
8,705,578 bp from pter
End:
8,832,778 bp from pter
Size:
127,201 bases
Orientation:
Plus strand

Genomic View for MTCL1 Gene

Genes around MTCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCL1 Gene

Proteins for MTCL1 Gene

  • Protein details for MTCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4B5-MTCL1_HUMAN
    Recommended name:
    Microtubule cross-linking factor 1
    Protein Accession:
    Q9Y4B5
    Secondary Accessions:
    • E9PAY7
    • Q6ZMQ9
    • Q8IWA9

    Protein attributes for MTCL1 Gene

    Size:
    1905 amino acids
    Molecular mass:
    209526 Da
    Quaternary structure:
    • Isoform 1 interacts with MARK2; the interaction increases MARK2 microtubule-binding ability (By similarity). Homodimer. Associates (via N- and C-terminus domains) with microtubule filaments. Isoform 2 interacts with MARK2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAA34522.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTCL1 Gene

Post-translational modifications for MTCL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTCL1 Gene

Domains & Families for MTCL1 Gene

Gene Families for MTCL1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MTCL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4B5

UniProtKB/Swiss-Prot:

MTCL1_HUMAN :
  • Belongs to the SOGA family.
Family:
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with MTCL1: view

Function for MTCL1 Gene

Molecular function for MTCL1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells.

Phenotypes From GWAS Catalog for MTCL1 Gene

Gene Ontology (GO) - Molecular Function for MTCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008017 microtubule binding IDA 23902687
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with MTCL1: view
genes like me logo Genes that share phenotypes with MTCL1: view

Animal Model Products

CRISPR Products

miRNA for MTCL1 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTCL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTCL1 Gene

Localization for MTCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCL1 Gene

Lateral cell membrane. Apical cell membrane. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton. Note=Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTCL1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
nucleus 4
extracellular 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MTCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 23902687
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA,IDA 23902687
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with MTCL1: view

Pathways & Interactions for MTCL1 Gene

SuperPathways for MTCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IBA,ISS --
GO:0010506 regulation of autophagy IEA --
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity ISS,IBA --
GO:0090314 positive regulation of protein targeting to membrane ISS --
GO:2000576 positive regulation of microtubule motor activity ISS --
genes like me logo Genes that share ontologies with MTCL1: view

No data available for Pathways by source and SIGNOR curated interactions for MTCL1 Gene

Drugs & Compounds for MTCL1 Gene

No Compound Related Data Available

Transcripts for MTCL1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTCL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MTCL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11: - -
SP12:

ExUns: 19b · 19c · 19d ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MTCL1 Gene

GeneLoc Exon Structure for
MTCL1
ECgene alternative splicing isoforms for
MTCL1

Expression for MTCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTCL1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x15.0) and Brain - Cerebellum (x14.6).

Protein differential expression in normal tissues from HIPED for MTCL1 Gene

This gene is overexpressed in Plasma (44.5), Cervix (12.1), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTCL1 Gene



Protein tissue co-expression partners for MTCL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTCL1 Gene:

MTCL1

Evidence on tissue expression from TISSUES for MTCL1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MTCL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTCL1 Gene

Orthologs for MTCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SOGA2 34 33
  • 99.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SOGA2 34 33
  • 85.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Soga2 33
  • 83.77 (n)
mouse
(Mus musculus)
Mammalia Soga2 34 33
  • 83.1 (n)
OneToOne
Mtcl1 16
cow
(Bos Taurus)
Mammalia CCDC165 33
  • 81.47 (n)
SOGA2 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SOGA2 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOGA2 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOGA2 33
  • 71.94 (n)
-- 34
  • 68 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101884972 33
  • 57.54 (n)
CABZ01050280.1 34
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18304 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-241 34
  • 12 (a)
OneToMany
Species where no ortholog for MTCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTCL1 Gene

ENSEMBL:
Gene Tree for MTCL1 (if available)
TreeFam:
Gene Tree for MTCL1 (if available)

Paralogs for MTCL1 Gene

Paralogs for MTCL1 Gene

Pseudogenes.org Pseudogenes for MTCL1 Gene

genes like me logo Genes that share paralogs with MTCL1: view

Variants for MTCL1 Gene

Sequence variations from dbSNP and Humsavar for MTCL1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000002519 -- 8,705,742(+) ACCAC(C/G)ACCTC intron-variant, upstream-variant-2KB, reference, missense
rs1000029746 -- 8,764,633(+) CCCCC(C/T)ACTTT intron-variant
rs1000030394 -- 8,799,695(+) ACCTC(G/T)CCACA intron-variant
rs1000033614 -- 8,705,538(+) CGCAG(A/C)CCGGG intron-variant, upstream-variant-2KB
rs1000077370 -- 8,780,475(+) TCCTT(A/G)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTCL1 Gene

Variant ID Type Subtype PubMed ID
dgv53n17 CNV loss 16327808
esv1962484 CNV deletion 18987734
esv2716759 CNV deletion 23290073
esv3308790 CNV mobile element insertion 20981092
esv3382058 CNV insertion 20981092
esv3417113 CNV insertion 20981092
esv3641725 CNV loss 21293372
esv3641726 CNV loss 21293372
nsv1131352 CNV deletion 24896259
nsv516355 CNV loss 19592680
nsv517204 CNV loss 19592680
nsv521231 CNV loss 19592680
nsv523589 CNV loss 19592680
nsv833584 CNV gain+loss 17160897
nsv960249 CNV duplication 23825009

Variation tolerance for MTCL1 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.55; 98.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCL1 Gene

Disorders for MTCL1 Gene

Relevant External Links for MTCL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTCL1

No disorders were found for MTCL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTCL1 Gene

Publications for MTCL1 Gene

  1. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. (PMID: 23902687) Sato Y … Suzuki A (Journal of cell science 2013) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 3 4 60

Products for MTCL1 Gene

Sources for MTCL1 Gene

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