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Aliases for MTCL1 Gene

Aliases for MTCL1 Gene

  • Microtubule Crosslinking Factor 1 2 3 5
  • SOGA Family Member 2 2 3 4
  • KIAA0802 2 3 4
  • Coiled-Coil Domain-Containing Protein 165 3 4
  • Coiled-Coil Domain Containing 165 2 3
  • PAR-1-Interacting Protein 3 4
  • CCDC165 3 4
  • SOGA2 3 4
  • Protein SOGA2 3

External Ids for MTCL1 Gene

Previous HGNC Symbols for MTCL1 Gene

  • KIAA0802
  • CCDC165
  • SOGA2

Summaries for MTCL1 Gene

GeneCards Summary for MTCL1 Gene

MTCL1 (Microtubule Crosslinking Factor 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and microtubule binding. An important paralog of this gene is SOGA1.

UniProtKB/Swiss-Prot for MTCL1 Gene

  • Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells.

Gene Wiki entry for MTCL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCL1 Gene

Genomics for MTCL1 Gene

Regulatory Elements for MTCL1 Gene

Promoters for MTCL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTCL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTCL1 Gene

Chromosome:
18
Start:
8,705,578 bp from pter
End:
8,832,778 bp from pter
Size:
127,201 bases
Orientation:
Plus strand

Genomic View for MTCL1 Gene

Genes around MTCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCL1 Gene

Proteins for MTCL1 Gene

  • Protein details for MTCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4B5-MTCL1_HUMAN
    Recommended name:
    Microtubule cross-linking factor 1
    Protein Accession:
    Q9Y4B5
    Secondary Accessions:
    • E9PAY7
    • Q6ZMQ9
    • Q8IWA9

    Protein attributes for MTCL1 Gene

    Size:
    1905 amino acids
    Molecular mass:
    209526 Da
    Quaternary structure:
    • Isoform 1 interacts with MARK2; the interaction increases MARK2 microtubule-binding ability (By similarity). Homodimer. Associates (via N- and C-terminus domains) with microtubule filaments. Isoform 2 interacts with MARK2; the interaction is direct.
    SequenceCaution:
    • Sequence=BAA34522.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTCL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTCL1 Gene

Proteomics data for MTCL1 Gene at MOPED

Post-translational modifications for MTCL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTCL1 Gene

No data available for DME Specific Peptides for MTCL1 Gene

Domains & Families for MTCL1 Gene

Protein Domains for MTCL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MTCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4B5

UniProtKB/Swiss-Prot:

MTCL1_HUMAN :
  • Belongs to the SOGA family.
Family:
  • Belongs to the SOGA family.
genes like me logo Genes that share domains with MTCL1: view

No data available for Gene Families for MTCL1 Gene

Function for MTCL1 Gene

Molecular function for MTCL1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells.

Gene Ontology (GO) - Molecular Function for MTCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MTCL1: view
genes like me logo Genes that share phenotypes with MTCL1: view

Animal Model Products

miRNA for MTCL1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MTCL1 Gene

Localization for MTCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCL1 Gene

Lateral cell membrane. Apical cell membrane. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm, cytoskeleton. Note=Colocalized with microtubules at the base of cilia. Gradually accumulates on the apicobasal microtubule bundles during epithelial cell polarization (By similarity). Colocalized with the apicobasal microtubule bundles running beneath the lateral membrane. Colocalized with microtubule bundles in the spindle pole in mitotic cells and in the midbodies at the end of cytokinesis. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MTCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 23902687
GO:0016324 apical plasma membrane IEA --
GO:0097427 microtubule bundle ISS --
genes like me logo Genes that share ontologies with MTCL1: view

No data available for Subcellular locations from COMPARTMENTS for MTCL1 Gene

Pathways & Interactions for MTCL1 Gene

SuperPathways for MTCL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010506 regulation of autophagy IEA --
GO:0090314 positive regulation of protein targeting to membrane ISS --
genes like me logo Genes that share ontologies with MTCL1: view

No data available for Pathways by source and SIGNOR curated interactions for MTCL1 Gene

Drugs & Compounds for MTCL1 Gene

No Compound Related Data Available

Transcripts for MTCL1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MTCL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11: - -
SP12:

ExUns: 19b · 19c · 19d ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MTCL1 Gene

GeneLoc Exon Structure for
MTCL1
ECgene alternative splicing isoforms for
MTCL1

Expression for MTCL1 Gene

mRNA expression in normal human tissues for MTCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTCL1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x15.0) and Brain - Cerebellum (x14.6).

Protein differential expression in normal tissues from HIPED for MTCL1 Gene

This gene is overexpressed in Plasma (44.5), Cervix (12.1), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MTCL1 Gene



genes like me logo Genes that share expression patterns with MTCL1: view

Protein tissue co-expression partners for MTCL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MTCL1 Gene

Orthologs for MTCL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC165 35
  • 81.47 (n)
  • 79.22 (a)
SOGA2 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Soga2 35
  • 83.1 (n)
  • 83.93 (a)
Mtcl1 16
Soga2 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SOGA2 35
  • 99.13 (n)
  • 99.3 (a)
SOGA2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Soga2 35
  • 83.77 (n)
  • 84.6 (a)
dog
(Canis familiaris)
Mammalia SOGA2 36
  • 73 (a)
OneToOne
SOGA2 35
  • 85.25 (n)
  • 84.67 (a)
oppossum
(Monodelphis domestica)
Mammalia SOGA2 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SOGA2 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves SOGA2 35
  • 71.94 (n)
  • 71.09 (a)
-- 36
  • 68 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101884972 35
  • 57.54 (n)
  • 52.35 (a)
CABZ01050280.1 36
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18304 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-241 36
  • 12 (a)
OneToMany
Species with no ortholog for MTCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MTCL1 Gene

ENSEMBL:
Gene Tree for MTCL1 (if available)
TreeFam:
Gene Tree for MTCL1 (if available)

Paralogs for MTCL1 Gene

Paralogs for MTCL1 Gene

Pseudogenes.org Pseudogenes for MTCL1 Gene

genes like me logo Genes that share paralogs with MTCL1: view

Variants for MTCL1 Gene

Sequence variations from dbSNP and Humsavar for MTCL1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1965665 - 8,784,614(+) GGAGC(A/G)GGGTG reference, missense
rs3744979 - 8,784,725(-) GGCCA(C/T)CCCCA reference, missense
rs12386117 - 8,798,187(+) ACCGA(A/G)GCTGT reference, missense
rs11874468 - 8,813,048(+) TGAAG(A/C)AGGAG reference, missense
rs35739383 - 8,783,837(-) CCCGC(A/G)TGTCC reference, missense

Variation tolerance for MTCL1 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.55; 98.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTCL1 Gene

HapMap Linkage Disequilibrium report
MTCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MTCL1 Gene

Disorders for MTCL1 Gene

Relevant External Links for MTCL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTCL1

No disorders were found for MTCL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTCL1 Gene

Publications for MTCL1 Gene

  1. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. (PMID: 23902687) Sato Y. … Suzuki A. (J. Cell. Sci. 2013) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H. … D'Andrea A.D. (Mol. Cell 2014) 3

Products for MTCL1 Gene

Sources for MTCL1 Gene

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