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Aliases for MTCH2 Gene

Aliases for MTCH2 Gene

  • Mitochondrial Carrier 2 2 3 5
  • Solute Carrier Family 25, Member 50 2 3
  • Met-Induced Mitochondrial Protein 3 4
  • MIMP 3 4
  • Mitochondrial Carrier Homolog 2 (C. Elegans) 2
  • Mitochondrial Carrier Homolog 2 3
  • 2310034D24Rik 3
  • SLC25A50 3
  • HSPC032 3

External Ids for MTCH2 Gene

Previous GeneCards Identifiers for MTCH2 Gene

  • GC11U990208
  • GC11M048517
  • GC11M047670
  • GC11M047604
  • GC11M047600
  • GC11M047595
  • GC11M047639
  • GC11M047341
  • GC11M047745
  • GC11M048081
  • GC11M048804
  • GC11M049909
  • GC11M047855
  • GC11M047959
  • GC11M050806
  • GC11M051601

Summaries for MTCH2 Gene

Entrez Gene Summary for MTCH2 Gene

  • This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

GeneCards Summary for MTCH2 Gene

MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. Diseases associated with MTCH2 include Obesity. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot for MTCH2 Gene

  • The substrate transported is not yet known. Induces mitochondrial depolarization.

Gene Wiki entry for MTCH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene

Genomics for MTCH2 Gene

Regulatory Elements for MTCH2 Gene

Enhancers for MTCH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F047506 1.7 FANTOM5 Ensembl ENCODE 10.4 +129.2 129154 14.6 HDGF PKNOX1 WRNIP1 ZFP64 ZNF493 SIN3A FEZF1 ZNF2 ZNF121 GATA2 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 DDB2 ZNF408 CELF1 SLC39A13 NDUFS3
GH11F047853 1.3 Ensembl ENCODE 9.8 -217.0 -217028 12.6 PKNOX1 BRCA1 GTF3C2 CBX5 FOS DEK JUNB ZNF623 ZNF518A MEF2D C1QTNF4 FNBP4 NUP160 ENSG00000270060 ENSG00000200090 DDB2 MYBPC3 KBTBD4 MTCH2 PTPRJ
GH11F047498 1.2 Ensembl ENCODE 10.3 +143.5 143454 2.4 ZNF493 WRNIP1 ZFP64 RAD21 ZNF155 YY1 ZEB1 ZNF354C ZNF138 KLF7 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 DDB2 ZNF408 SLC39A13 KBTBD4 NDUFS3 PTPMT1
GH11F047537 1.1 Ensembl ENCODE 10.8 +102.5 102454 6.0 PKNOX1 INSM2 KLF17 SIN3A FEZF1 RAD21 ZNF2 ZNF121 ZNF366 SCRT2 C1QTNF4 PTPMT1 NDUFS3 CELF1 KBTBD4 ENSG00000231880 RNU5E-10P MADD MTCH2 FNBP4
GH11F047454 1.1 Ensembl ENCODE 9.8 +188.3 188254 0.4 ELF3 ARID4B ZNF2 RAD21 RFX5 ZNF143 RCOR1 CREM DEK THAP11 NDUFS3 MTCH2 RAPSN GC11M053351
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTCH2 on UCSC Golden Path with GeneCards custom track

Promoters for MTCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000562217 354 2600 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for MTCH2 Gene

Chromosome:
11
Start:
47,605,204 bp from pter
End:
47,642,654 bp from pter
Size:
37,451 bases
Orientation:
Minus strand

Genomic View for MTCH2 Gene

Genes around MTCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH2 Gene

Proteins for MTCH2 Gene

  • Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6C9-MTCH2_HUMAN
    Recommended name:
    Mitochondrial carrier homolog 2
    Protein Accession:
    Q9Y6C9
    Secondary Accessions:
    • B2R7L8

    Protein attributes for MTCH2 Gene

    Size:
    303 amino acids
    Molecular mass:
    33331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTCH2 Gene

Post-translational modifications for MTCH2 Gene

  • Ubiquitination at Lys 90, Lys 100, Lys 122, Lys 293, and Lys 300
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTCH2 Gene

Domains & Families for MTCH2 Gene

Gene Families for MTCH2 Gene

Protein Domains for MTCH2 Gene

Suggested Antigen Peptide Sequences for MTCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6C9

UniProtKB/Swiss-Prot:

MTCH2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 2 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 2 Solcar repeats.
genes like me logo Genes that share domains with MTCH2: view

Function for MTCH2 Gene

Molecular function for MTCH2 Gene

UniProtKB/Swiss-Prot Function:
The substrate transported is not yet known. Induces mitochondrial depolarization.
genes like me logo Genes that share phenotypes with MTCH2: view

Animal Models for MTCH2 Gene

MGI Knock Outs for MTCH2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTCH2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTCH2 Gene

Localization for MTCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTCH2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA,IBA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with MTCH2: view

Pathways & Interactions for MTCH2 Gene

SuperPathways for MTCH2 Gene

No Data Available

SIGNOR curated interactions for MTCH2 Gene

Activates:

Gene Ontology (GO) - Biological Process for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006089 lactate metabolic process IEA --
GO:0006810 transport IEA --
GO:0010917 negative regulation of mitochondrial membrane potential IEA --
GO:0035701 hematopoietic stem cell migration IEA --
GO:0042775 mitochondrial ATP synthesis coupled electron transport IEA --
genes like me logo Genes that share ontologies with MTCH2: view

No data available for Pathways by source for MTCH2 Gene

Transcripts for MTCH2 Gene

Unigene Clusters for MTCH2 Gene

Mitochondrial carrier 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MTCH2 Gene

GeneLoc Exon Structure for
MTCH2
ECgene alternative splicing isoforms for
MTCH2

Expression for MTCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MTCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTCH2 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTCH2 Gene



Protein tissue co-expression partners for MTCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTCH2 Gene:

MTCH2

SOURCE GeneReport for Unigene cluster for MTCH2 Gene:

Hs.269944
genes like me logo Genes that share expression patterns with MTCH2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTCH2 Gene

Orthologs for MTCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTCH2 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia MTCH2 34
  • 94.33 (n)
-- 35
  • 82 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MTCH2 34 35
  • 92.63 (n)
mouse
(Mus musculus)
Mammalia Mtch2 34 16 35
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Mtch2 34
  • 90.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTCH2 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTCH2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTCH2 34 35
  • 70.41 (n)
lizard
(Anolis carolinensis)
Reptilia MTCH2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtch2 34
  • 68.81 (n)
MGC76005 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64562 34
zebrafish
(Danio rerio)
Actinopterygii mtch2 34 35
  • 66.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.100 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006963 34
  • 47.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mtch 36 34 35
  • 46.64 (n)
CG10920 36 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea mtch-1 34 35
  • 43.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 35
  • 35 (a)
OneToMany
Species where no ortholog for MTCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTCH2 Gene

ENSEMBL:
Gene Tree for MTCH2 (if available)
TreeFam:
Gene Tree for MTCH2 (if available)

Paralogs for MTCH2 Gene

Paralogs for MTCH2 Gene

(2) SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MTCH2 Gene

genes like me logo Genes that share paralogs with MTCH2: view

Variants for MTCH2 Gene

Sequence variations from dbSNP and Humsavar for MTCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1056027 -- 47,627,766(-) atgct(G/T)taatc intron-variant
rs1064608 -- 47,618,877(-) AGGTC(C/G)CCTTT intron-variant, reference, missense, utr-variant-3-prime
rs10769281 -- 47,604,538(+) tacat(C/G)ttatt utr-variant-3-prime
rs10769282 -- 47,604,940(+) TTTTG(G/T)TTTTT downstream-variant-500B, utr-variant-3-prime
rs10769283 -- 47,640,580(+) ccagc(C/T)aattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTCH2 Gene

Variant ID Type Subtype PubMed ID
nsv832142 CNV loss 17160897
nsv825872 CNV gain 20364138
nsv69 CNV insertion 15895083
nsv509405 CNV insertion 20534489
nsv469858 CNV gain 16826518
nsv315 CNV insertion 18451855
esv998557 CNV insertion 20482838
esv995881 CNV insertion 20482838
esv3626206 CNV loss 21293372
esv2744440 CNV deletion 23290073
esv1465053 CNV insertion 17803354

Variation tolerance for MTCH2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.52; 88.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTCH2 Gene

Human Gene Mutation Database (HGMD)
MTCH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene

Disorders for MTCH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTCH2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search MTCH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTCH2

Genetic Association Database (GAD)
MTCH2
Human Genome Epidemiology (HuGE) Navigator
MTCH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTCH2
genes like me logo Genes that share disorders with MTCH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTCH2 Gene

Publications for MTCH2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 22 46 64
  2. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PMID: 19746409) Brandys M.K. … Adan R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. (PMID: 19812171) Li S. … Loos R.J. (Am. J. Clin. Nutr. 2010) 3 46 64
  4. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. (PMID: 19910641) He M. … Qi L. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 46 64
  5. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study. (PMID: 19910938) Haupt A. … Staiger H. (Obesity (Silver Spring) 2010) 3 46 64

Products for MTCH2 Gene

Sources for MTCH2 Gene

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