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Aliases for MTCH2 Gene

Aliases for MTCH2 Gene

  • Mitochondrial Carrier 2 2 3
  • Met-Induced Mitochondrial Protein 3 4
  • MIMP 3 4
  • Mitochondrial Carrier Homolog 2 (C. Elegans) 2
  • Solute Carrier Family 25, Member 50 3
  • Mitochondrial Carrier Homolog 2 3
  • Solute Carrier Family 25 2
  • 2310034D24Rik 3
  • Member 50 2
  • SLC25A50 3
  • HSPC032 3

External Ids for MTCH2 Gene

Summaries for MTCH2 Gene

GeneCards Summary for MTCH2 Gene

MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot for MTCH2 Gene

  • The substrate transported is not yet known. Induces mitochondrial depolarization

Gene Wiki entry for MTCH2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene

Genomics for MTCH2 Gene

Genomic Location for MTCH2 Gene

Start:
47,617,306 bp from pter
End:
47,642,654 bp from pter
Size:
25,349 bases
Orientation:
Minus strand

Genomic View for MTCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH2 Gene

Regulatory Elements for MTCH2 Gene

Proteins for MTCH2 Gene

  • Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6C9-MTCH2_HUMAN
    Recommended name:
    Mitochondrial carrier homolog 2
    Protein Accession:
    Q9Y6C9
    Secondary Accessions:
    • B2R7L8

    Protein attributes for MTCH2 Gene

    Size:
    303 amino acids
    Molecular mass:
    33331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTCH2 Gene

Proteomics data for MTCH2 Gene at MOPED

Post-translational modifications for MTCH2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90, Lys100, Lys122, Lys293, and Lys300

Other Protein References for MTCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTCH2 Gene

Domains for MTCH2 Gene

Gene Families for MTCH2 Gene

HGNC:
  • SLC :Solute carriers

Protein Domains for MTCH2 Gene

UniProtKB/Swiss-Prot:

MTCH2_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q9Y6C9
Similarity:
  • Contains 2 Solcar repeats.:
    • Q9Y6C9
genes like me logo Genes that share domains with MTCH2: view

Function for MTCH2 Gene

Molecular function for MTCH2 Gene

UniProtKB/Swiss-Prot Function: The substrate transported is not yet known. Induces mitochondrial depolarization

miRNA for MTCH2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTCH2 Gene

Localization for MTCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTCH2 Gene COMPARTMENTS Subcellular localization image for MTCH2 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MTCH2: view

Pathways for MTCH2 Gene

SuperPathways for MTCH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0070585 protein localization to mitochondrion IMP 23744079
GO:0097284 hepatocyte apoptotic process IEA --
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IEA --
genes like me logo Genes that share ontologies with MTCH2: view

No data available for Pathways by source for MTCH2 Gene

Transcripts for MTCH2 Gene

Unigene Clusters for MTCH2 Gene

Mitochondrial carrier 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MTCH2 Gene

GeneLoc Exon Structure for
MTCH2
ECgene alternative splicing isoforms for
MTCH2

Expression for MTCH2 Gene

mRNA expression in normal human tissues for MTCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTCH2 Gene

SOURCE GeneReport for Unigene cluster for MTCH2 Gene Hs.269944

genes like me logo Genes that share expressions with MTCH2: view

Orthologs for MTCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTCH2 36
  • 100 (n)
  • 100 (a)
MTCH2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTCH2 36
  • 92.63 (n)
  • 94.39 (a)
MTCH2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
MTCH2 36
  • 94.33 (n)
  • 94.56 (a)
mouse
(Mus musculus)
Mammalia Mtch2 36
  • 91.09 (n)
  • 93.73 (a)
Mtch2 16
Mtch2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTCH2 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTCH2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtch2 36
  • 90.87 (n)
  • 92.41 (a)
chicken
(Gallus gallus)
Aves MTCH2 36
  • 70.41 (n)
  • 80.27 (a)
MTCH2 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTCH2 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64562 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76005 36
mtch2 36
  • 68.81 (n)
  • 71.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.100 36
zebrafish
(Danio rerio)
Actinopterygii mtch2 36
  • 66.78 (n)
  • 70.37 (a)
mtch2 37
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006963 36
  • 47.02 (n)
  • 40.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10920 37
  • 24 (a)
ManyToMany
Mtch 36
  • 46.64 (n)
  • 40.68 (a)
Mtch 37
  • 34 (a)
ManyToMany
CG10920 38
  • 34 (a)
Mtch 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea mtch-1 36
  • 43.35 (n)
  • 30.74 (a)
mtch-1 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 37
  • 35 (a)
OneToMany
Species with no ortholog for MTCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTCH2 Gene

ENSEMBL:
Gene Tree for MTCH2 (if available)
TreeFam:
Gene Tree for MTCH2 (if available)

Paralogs for MTCH2 Gene

Paralogs for MTCH2 Gene

Selected SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTCH2: view

Variants for MTCH2 Gene

Sequence variations from dbSNP and Humsavar for MTCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9089 -- 47,617,511(-) CTTCC(C/T)TCCCC utr-variant-3-prime
rs1056027 -- 47,627,766(-) atgct(G/T)taatc intron-variant
rs1064608 - 47,618,877(-) AGGTC(C/G)CCTTT reference, missense, utr-variant-3-prime
rs1568166 -- 47,643,639(+) AAAGG(A/C)ATTGT upstream-variant-2KB
rs3817334 -- 47,629,441(+) AAAGA(C/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTCH2 Gene

Variant ID Type Subtype PubMed ID
nsv832142 CNV Loss 17160897
nsv825872 CNV Gain 20364138
nsv509405 CNV Insertion 20534489
esv2744440 CNV Deletion 23290073
nsv469858 CNV Gain 16826518
nsv69 CNV Insertion 15895083
nsv315 CNV Insertion 18451855
esv995881 CNV Insertion 20482838
esv998557 CNV Insertion 20482838
esv1465053 CNV Insertion 17803354

Relevant External Links for MTCH2 Gene

HapMap Linkage Disequilibrium report
MTCH2
Human Gene Mutation Database (HGMD)
MTCH2

Disorders for MTCH2 Gene

Relevant External Links for MTCH2

Genetic Association Database (GAD)
MTCH2
Human Genome Epidemiology (HuGE) Navigator
MTCH2
genes like me logo Genes that share disorders with MTCH2: view

No data available for UniProtKB/Swiss-Prot for MTCH2 Gene

Publications for MTCH2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23 49
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization. (PMID: 12407445) Yerushalmi G.M. … Tsarfaty I. (Neoplasia 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer C.J. … Hirschhorn J.N. (Nat. Genet. 2009) 3 49

Products for MTCH2 Gene

Sources for MTCH2 Gene

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