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Aliases for MTCH2 Gene

Aliases for MTCH2 Gene

  • Mitochondrial Carrier 2 2 3 5
  • Met-Induced Mitochondrial Protein 3 4
  • MIMP 3 4
  • Mitochondrial Carrier Homolog 2 (C. Elegans) 2
  • Solute Carrier Family 25, Member 50 3
  • Solute Carrier Family 25 2
  • 2310034D24Rik 3
  • Member 50 2
  • SLC25A50 3
  • HSPC032 3

External Ids for MTCH2 Gene

Previous GeneCards Identifiers for MTCH2 Gene

  • GC11U990208
  • GC11M048517
  • GC11M047670
  • GC11M047604
  • GC11M047600
  • GC11M047595
  • GC11M047639
  • GC11M047341
  • GC11M047745
  • GC11M048081
  • GC11M048804
  • GC11M049909
  • GC11M047855
  • GC11M047959

Summaries for MTCH2 Gene

Entrez Gene Summary for MTCH2 Gene

  • This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

GeneCards Summary for MTCH2 Gene

MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. Diseases associated with MTCH2 include Obesity. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot for MTCH2 Gene

  • The substrate transported is not yet known. Induces mitochondrial depolarization.

Gene Wiki entry for MTCH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene

Genomics for MTCH2 Gene

Regulatory Elements for MTCH2 Gene

Enhancers for MTCH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTCH2 on UCSC Golden Path with GeneCards custom track

Promoters for MTCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MTCH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MTCH2 Gene

Chromosome:
11
Start:
47,605,204 bp from pter
End:
47,642,654 bp from pter
Size:
37,451 bases
Orientation:
Minus strand

Genomic View for MTCH2 Gene

Genes around MTCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH2 Gene

Proteins for MTCH2 Gene

  • Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6C9-MTCH2_HUMAN
    Recommended name:
    Mitochondrial carrier homolog 2
    Protein Accession:
    Q9Y6C9
    Secondary Accessions:
    • B2R7L8

    Protein attributes for MTCH2 Gene

    Size:
    303 amino acids
    Molecular mass:
    33331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTCH2 Gene

Proteomics data for MTCH2 Gene at MOPED

Post-translational modifications for MTCH2 Gene

  • Ubiquitination at Lys 90, Lys 100, Lys 122, Lys 293, and Lys 300
  • Modification sites at PhosphoSitePlus

Other Protein References for MTCH2 Gene

Antibody Products

  • Abcam antibodies for MTCH2

No data available for DME Specific Peptides for MTCH2 Gene

Domains & Families for MTCH2 Gene

Gene Families for MTCH2 Gene

Protein Domains for MTCH2 Gene

Suggested Antigen Peptide Sequences for MTCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6C9

UniProtKB/Swiss-Prot:

MTCH2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 2 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 2 Solcar repeats.
genes like me logo Genes that share domains with MTCH2: view

Function for MTCH2 Gene

Molecular function for MTCH2 Gene

UniProtKB/Swiss-Prot Function:
The substrate transported is not yet known. Induces mitochondrial depolarization.
genes like me logo Genes that share phenotypes with MTCH2: view

Animal Models for MTCH2 Gene

MGI Knock Outs for MTCH2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTCH2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTCH2 Gene

Localization for MTCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTCH2 Gene COMPARTMENTS Subcellular localization image for MTCH2 gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 4
cytosol 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MTCH2: view

Pathways & Interactions for MTCH2 Gene

SuperPathways for MTCH2 Gene

No Data Available

SIGNOR curated interactions for MTCH2 Gene

Activates:

Gene Ontology (GO) - Biological Process for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043065 positive regulation of apoptotic process IBA --
genes like me logo Genes that share ontologies with MTCH2: view

No data available for Pathways by source for MTCH2 Gene

Drugs & Compounds for MTCH2 Gene

No Compound Related Data Available

Transcripts for MTCH2 Gene

Unigene Clusters for MTCH2 Gene

Mitochondrial carrier 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MTCH2 Gene

GeneLoc Exon Structure for
MTCH2
ECgene alternative splicing isoforms for
MTCH2

Expression for MTCH2 Gene

mRNA expression in normal human tissues for MTCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTCH2 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTCH2 Gene



SOURCE GeneReport for Unigene cluster for MTCH2 Gene Hs.269944

genes like me logo Genes that share expression patterns with MTCH2: view

Protein tissue co-expression partners for MTCH2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MTCH2 Gene

Orthologs for MTCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTCH2 35
  • 92.63 (n)
  • 94.39 (a)
MTCH2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTCH2 35
  • 94.33 (n)
  • 94.56 (a)
-- 36
  • 82 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mtch2 35
  • 91.09 (n)
  • 93.73 (a)
Mtch2 16
Mtch2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTCH2 35
  • 100 (n)
  • 100 (a)
MTCH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtch2 35
  • 90.87 (n)
  • 92.41 (a)
oppossum
(Monodelphis domestica)
Mammalia MTCH2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTCH2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTCH2 35
  • 70.41 (n)
  • 80.27 (a)
MTCH2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTCH2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76005 35
mtch2 35
  • 68.81 (n)
  • 71.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64562 35
zebrafish
(Danio rerio)
Actinopterygii mtch2 35
  • 66.78 (n)
  • 70.37 (a)
mtch2 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.100 35
fruit fly
(Drosophila melanogaster)
Insecta CG10920 37
  • 34 (a)
Mtch 37
  • 38 (a)
Mtch 35
  • 46.64 (n)
  • 40.68 (a)
CG10920 36
  • 24 (a)
ManyToMany
Mtch 36
  • 34 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006963 35
  • 47.02 (n)
  • 40.3 (a)
worm
(Caenorhabditis elegans)
Secernentea mtch-1 35
  • 43.35 (n)
  • 30.74 (a)
mtch-1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 36
  • 35 (a)
OneToMany
Species with no ortholog for MTCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTCH2 Gene

ENSEMBL:
Gene Tree for MTCH2 (if available)
TreeFam:
Gene Tree for MTCH2 (if available)

Paralogs for MTCH2 Gene

Paralogs for MTCH2 Gene

(2) SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MTCH2: view

Variants for MTCH2 Gene

Sequence variations from dbSNP and Humsavar for MTCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs34072236 - 47,638,776(-) GGAGG(A/C/T)GCGGG reference, missense, utr-variant-5-prime
rs1064608 - 47,618,877(-) AGGTC(A/C/G)CCTTT intron-variant, reference, missense, utr-variant-3-prime
rs1056027 -- 47,627,766(-) atgct(G/T)taatc intron-variant
rs1474056 -- 47,611,155(-) ATAAT(C/T)TCCCT intron-variant
rs1568166 -- 47,643,639(+) AAAGG(A/C)ATTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MTCH2 Gene

Variant ID Type Subtype PubMed ID
nsv832142 CNV Loss 17160897
nsv825872 CNV Gain 20364138
nsv509405 CNV Insertion 20534489
esv2744440 CNV Deletion 23290073
nsv469858 CNV Gain 16826518
nsv69 CNV Insertion 15895083
nsv315 CNV Insertion 18451855
esv995881 CNV Insertion 20482838
esv998557 CNV Insertion 20482838
esv1465053 CNV Insertion 17803354

Variation tolerance for MTCH2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.52; 88.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTCH2 Gene

Human Gene Mutation Database (HGMD)
MTCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene

Disorders for MTCH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTCH2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search MTCH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTCH2

Genetic Association Database (GAD)
MTCH2
Human Genome Epidemiology (HuGE) Navigator
MTCH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTCH2
genes like me logo Genes that share disorders with MTCH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTCH2 Gene

Publications for MTCH2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MTCH2 Gene

Sources for MTCH2 Gene

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