Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTCH2 Gene

protein-coding   GIFtS: 54
GCID: GC11M048804

Mitochondrial Carrier 2

(Previous name: mitochondrial carrier homolog 2 (C. elegans))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Carrier 21 2     Solute Carrier Family 251
Met-Induced Mitochondrial Protein2 3     2310034D24Rik2
MIMP2 3     SLC25A502
Member 501     Mitochondrial Carrier Homolog 22
Mitochondrial Carrier Homolog 2 (C. Elegans)1     Solute Carrier Family 25, Member 502

External Ids:    HGNC: 175871   Entrez Gene: 237882   Ensembl: ENSG000001099197   OMIM: 6132215   UniProtKB: Q9Y6C93   

Export aliases for MTCH2 gene to outside databases

Previous GC identifers: GC11U990208 GC11M048517 GC11M047670 GC11M047604 GC11M047600 GC11M047595 GC11M047639 GC11M047341 GC11M047745 GC11M048081


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTCH2 Gene: 
MTCH2 (mitochondrial carrier 2) is a protein-coding gene. Diseases associated with MTCH2 include anorexia nervosa, and diabetes mellitus. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9
Function: The substrate transported is not yet known. Induces mitochondrial depolarization

Gene Wiki entry for MTCH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTCH2 gene promoter:
         NF-1   AML1a   Pax-2   MIF-1   Pax-2a   C/EBPalpha   MEF-2A   Pax-3   Pax-2b   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTCH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTCH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

MTCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTCH2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M048804:  view genomic region     (about GC identifiers)

Start:
47,638,858 bp from pter      End:
47,664,206 bp from pter
Size:
25,349 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9 (See protein sequence)
Recommended Name: Mitochondrial carrier homolog 2  
Size: 303 amino acids; 33331 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R7L8

Explore the universe of human proteins at neXtProt for MTCH2: NX_Q9Y6C9

Explore proteomics data for MTCH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6C9

  • MTCH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTCH2 Protein Expression
    REFSEQ proteins: NP_055157.1  
    ENSEMBL proteins: 
     ENSP00000303222   ENSP00000432043   ENSP00000439013  

    Human Recombinant Protein Products for MTCH2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MTCH2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MTCH2
    GenScript Custom Purified and Recombinant Proteins Services for MTCH2
    Novus Biologicals MTCH2 Proteins
    Novus Biologicals MTCH2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTCH2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    MTCH2 for ontologies           About GeneDecksing



    MTCH2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MTCH2
    GenScript Custom Superior Antibodies Services for MTCH2
    Novus Biologicals MTCH2 Antibodies
    Abcam antibodies for MTCH2
    Cloud-Clone Corp. Antibodies for MTCH2 
    ThermoFisher Antibody for MTCH2
    LSBio Antibodies in human, mouse, rat for MTCH2 

    Assay Products for MTCH2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTCH2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTCH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTCH2 
    Cloud-Clone Corp. CLIAs for MTCH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9Y6C9

    ProtoNet protein and cluster: Q9Y6C9

    UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 2 Solcar repeats


    MTCH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTCH2_HUMAN, Q9Y6C9
    Function: The substrate transported is not yet known. Induces mitochondrial depolarization

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MTCH2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MTCH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTCH2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTCH2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTCH2
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MTCH2 (see all 46):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-105 hsa-miR-4314 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidMTCH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MTCH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTCH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTCH2
    Sirion Biotech Customized adenovirus for overexpression of MTCH2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MTCH2 (see all 8)
    OriGene ORF clones in mouse, rat for MTCH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTCH2 (NM_014342)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH2
    Sirion Biotech Customized lentivirus for stable overexpression of MTCH2 
                         Customized lentivirus expression plasmids for stable overexpression of MTCH2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTCH2
    Search LifeMap BioReagents cell lines for MTCH2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTCH2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for MTCH2 (Q9Y6C93 ENSP000003032224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ESR1P033723I2D: score=2 
    YWHABP319463I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    MTCH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTCH2

    Search CenterWatch for drugs/clinical trials and news about MTCH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTCH2 gene: 
    NM_014342.3  

    Unigene Cluster for MTCH2:

    Mitochondrial carrier 2
    Hs.269944  [show with all ESTs]
    Unigene Representative Sequence: NM_014342
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539759 ENST00000302503(uc010rho.2 uc010rhp.2) ENST00000534074
    ENST00000525649 ENST00000530428 ENST00000533571 ENST00000542981
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTCH2
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MTCH2 (see all 46):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-105 hsa-miR-4314 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidMTCH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MTCH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTCH2
    Clone
    Products:
         
    OriGene clones in human, mouse for MTCH2 (see all 8)
    OriGene ORF clones in mouse, rat for MTCH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTCH2 (NM_014342)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH2
    Sirion Biotech Customized lentivirus for stable overexpression of MTCH2 
                         Customized lentivirus expression plasmids for stable overexpression of MTCH2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MTCH2
    OriGene qSTAR qPCR primer pairs in human, mouse for MTCH2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTCH2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTCH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTCH2

    Additional mRNA sequence: 

    AF085361.1 AF176008.1 AK223097.1 AK295218.1 AK313032.1 AY380792.1 BC000875.1 

    16 DOTS entries:

    DT.454735  DT.97862134  DT.100805067  DT.100833567  DT.100805069  DT.100805066  DT.92450572  DT.95099612 
    DT.95160519  DT.120745740  DT.92450569  DT.95160524  DT.100810427  DT.92471420  DT.95160523  DT.95202405 

    24/420 AceView cDNA sequences (see all 420):

    AI095805 AI798270 BU520979 BC000875 CR592236 AY380792 BG255456 AA111889 
    AI824162 AA312716 BM760097 BM827089 AI452396 BU535539 W79441 BI760664 
    CR618611 AW511451 CB144461 BQ960010 BU689100 AU280457 AI123520 BQ061976 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                -                                 
    SP2:                                            -                                   -                                 
    SP3:                                            -                                   -                                 
    SP4:                    -                                                                                             
    SP5:                                                                                -                 -               


    ECgene alternative splicing isoforms for MTCH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTCH2 expression in normal human tissues (normalized intensities)      MTCH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGCTCGG
    MTCH2 Expression
    About this image


    MTCH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Intestine (Gastrointestinal Tract)
             duodenum   
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Brain (Nervous System)
             Cerebellum
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)

    See MTCH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTCH2

    SOURCE GeneReport for Unigene cluster: Hs.269944
        SABiosciences Custom PCR Arrays for MTCH2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTCH2
    OriGene qSTAR qPCR primer pairs in human, mouse for MTCH2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTCH2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTCH2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTCH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MTCH2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtch21 , 5 mitochondrial carrier homolog 2 (C. elegans)1, 5 91.09(n)1
    93.73(a)1
      2 (50.41 cM)5
    564281  NM_019758.21  NP_062732.11 
     908471555 
    chicken
    (Gallus gallus)
    Aves MTCH21 mitochondrial carrier 2 70.41(n)
    80.27(a)
      395597  NM_204808.1  NP_990139.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTCH26
    mitochondrial carrier 2
    74(a)
    1 ↔ 1
    1(94133800-94155901)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC645622 mitochondrial carrier homolog 2 72.88(n)    BC054302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtch22 mitochondrial carrier homolog 2 73.67(n)   30655  BC055216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mtch1 , 3 carrier3
    Mitochondrial carrier homolog 11
    38(a)
    (best of 2)3
    46.64(n)1
    40.68(a)1
      61B23
    380261  NM_167800.21  NP_728482.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mtch-11 Protein MTCH-1 43.46(n)
    30.74(a)
      174207  NM_063144.4  NP_495545.3 


    ENSEMBL Gene Tree for MTCH2 (if available)
    TreeFam Gene Tree for MTCH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTCH2 gene
    MTCH12  
    2 SIMAP similar genes for MTCH2 using alignment to 3 protein entries:     MTCH2_HUMAN (see all proteins):
    PIG60    MTCH1

    MTCH2 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MTCH2
    PGOHUM00000239889 PGOHUM00000248894 PGOHUM00000259140 PGOHUM00000259141 PGOHUM00000237785


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/592 SNPs in MTCH2 are shown (see all 592)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169564781,2
    F--47638453(+) ATGGTC/TTCGAA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1484550051,2
    --47638480(+) AACCAC/TCTGCC 1 -- ds50010--------
    rs1427356841,2
    --47638488(+) GCCTCA/GGCCTC 1 -- ds50010--------
    rs2016987691,2
    C--47638555(+) ATGGC-/ACCTAC 1 -- ds50010--------
    rs1465200401,2
    C--47638628(+) ATGGAA/GGATCA 1 -- ds50010--------
    rs1399472601,2
    --47638634(+) GATCAC/TAGGTA 1 -- ds50010--------
    rs1431891251,2
    --47638905(+) TTTTGG/TGAGAA 1 -- ut310--------
    rs1896804161,2
    --47638953(+) GCAGAC/TAGTAA 1 -- ut310--------
    rs120991301,2
    C,F,A,H--47639010(+) AGAGAC/AATCAA 1 -- ut3117Minor allele frequency- A:0.10NS EA NA WA 1896
    rs1823117031,2
    --47639030(+) AAGCCA/GAGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTCH2 (47638858 - 47664206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MTCH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744440CNV Deletion23290073
    nsv509405CNV Insertion20534489
    esv995881CNV Insertion20482838
    esv1465053CNV Insertion17803354
    esv998557CNV Insertion20482838
    nsv69CNV Insertion15895083
    nsv315CNV Insertion18451855
    nsv832142CNV Loss17160897
    nsv469858CNV Gain16826518
    nsv825872CNV Gain20364138


    Human Gene Mutation Database (HGMD): MTCH2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MTCH2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTCH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613221    OMIM disorders: --

    4 diseases for MTCH2:    About MalaCards
    anorexia nervosa    diabetes mellitus    obesity    neuronitis


    MTCH2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTCH2
    Human Genome Epidemiology (HuGE) Navigator: MTCH2 (24 documents)

    Export disorders for MTCH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTCH2 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with MTCH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between obesity and polymorphisms in SEC1 6B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 4, 9 Hotta K....Nakamura Y. (2009)
    2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    3. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide assoc iation studies. (PubMed id 20724581)1, 4 den Hoed M....Loos R.J. (2010)
    4. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    5. Implication of genetic variants near NEGR1, SEC16B, T MEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, a nd KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (2010)
    6. Are recently identified genetic variants regulating B MI in the general population associated with anorexia nervosa? (PubMed id 19746409)1, 4 Brandys M.K....Adan R.A. (2010)
    7. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (2010)
    8. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    10. Obesity genotype score and cardiovascular risk in wom en with type 2 diabetes mellitus. (PubMed id 19910641)1, 4 He M....Qi L. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23788 HGNC: 17587 AceView: MTCH2 Ensembl:ENSG00000109919 euGenes: HUgn23788
    ECgene: MTCH2 H-InvDB: MTCH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTCH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTCH2 gene:
    Search GeneIP for patents involving MTCH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MTCH2  
     OriGene qPCR primer pairs and template standards for MTCH2   OriGene Protein Over-expression Lysate for MTCH2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MTCH2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MTCH2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MTCH2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTCH2   OriGene Custom Protein Services for MTCH2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTCH2
     QIAGEN SeqTarget long-range PCR primers for resequencing MTCH2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTCH2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTCH2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTCH2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTCH2
     GenScript Custom Purified and Recombinant Proteins Services for MTCH2 GenScript cDNA clones with any tag delivered in your preferred vector for MTCH2
     GenScript Custom Assay Services for MTCH2 GenScript Custom Superior Antibodies Services for MTCH2
     GenScript Custom overexpressing Cell Line Services for MTCH2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MTCH2 promoter
     Search Chromatin IP Primers for MTCH2
     RT2 qPCR Primer Assay in human, mouse, rat MTCH2
     Search GNC Networks for MTCH2
     SABiosciences Custom PCR Arrays for MTCH2
     Search Tocris compounds for MTCH2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MTCH2 antibodies
     MTCH2 proteins
     MTCH2 lysates
     Antibodies for MTCH2
     See all of Abcam's Antibodies, Kits and Proteins for MTCH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MTCH2
     Antibodies for MTCH2
     ELISAs for MTCH2
     CLIAs for MTCH2
     Search LifeMap BioReagents cell lines for MTCH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH2
     SwitchGear 3'UTR luciferase reporter plasmids for MTCH2
     SwitchGear Promoter luciferase reporter plasmids for MTCH2
     ThermoFisher Antibody for MTCH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MTCH2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MTCH2
    Customized:
     lentivirus for stable overexpression of MTCH2
     lentivirus expression plasmids for stable overexpression of MTCH2
     adenovirus for overexpression of MTCH2
     LSBio Antibodies in human, mouse, rat for MTCH2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTCH2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4