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Aliases for MTCH2 Gene

Aliases for MTCH2 Gene

  • Mitochondrial Carrier 2 2 3 5
  • Solute Carrier Family 25, Member 50 2 3
  • Met-Induced Mitochondrial Protein 3 4
  • MIMP 3 4
  • Mitochondrial Carrier Homolog 2 (C. Elegans) 2
  • Mitochondrial Carrier Homolog 2 3
  • 2310034D24Rik 3
  • SLC25A50 3
  • HSPC032 3

External Ids for MTCH2 Gene

Previous GeneCards Identifiers for MTCH2 Gene

  • GC11U990208
  • GC11M048517
  • GC11M047670
  • GC11M047604
  • GC11M047600
  • GC11M047595
  • GC11M047639
  • GC11M047341
  • GC11M047745
  • GC11M048081
  • GC11M048804
  • GC11M049909
  • GC11M047855
  • GC11M047959
  • GC11M050806
  • GC11M051601
  • GC11M052263
  • GC11M052923

Summaries for MTCH2 Gene

Entrez Gene Summary for MTCH2 Gene

  • This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

GeneCards Summary for MTCH2 Gene

MTCH2 (Mitochondrial Carrier 2) is a Protein Coding gene. Diseases associated with MTCH2 include Obesity. An important paralog of this gene is MTCH1.

UniProtKB/Swiss-Prot for MTCH2 Gene

  • The substrate transported is not yet known. Induces mitochondrial depolarization.

Gene Wiki entry for MTCH2 Gene

Additional gene information for MTCH2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH2 Gene

Genomics for MTCH2 Gene

Regulatory Elements for MTCH2 Gene

Enhancers for MTCH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H047506 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +129.1 129073 14 HDGF PKNOX1 ZFP64 FOS ZC3H11A JUNB REST SREBF1 SMARCA4 GLIS1 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 DDB2 ZNF408 SLC39A13 AMBRA1 CELF1
GH11H047537 1.4 Ensembl ENCODE dbSUPER 10.8 +103.3 103262 4 PKNOX1 INSM2 KLF17 SIN3A FEZF1 RAD21 ZNF2 ZNF366 SCRT2 ZNF391 C1QTNF4 NDUFS3 PTPMT1 CELF1 KBTBD4 ENSG00000231880 RNU5E-10P MADD MTCH2 FNBP4
GH11H047853 1.5 Ensembl ENCODE dbSUPER 9.8 -216.9 -216899 12 PKNOX1 BRCA1 TCF12 GTF3C2 ZNF143 ATF7 FOS RUNX3 DEK JUNB C1QTNF4 FNBP4 ARFGAP2 NUP160 ENSG00000270060 ENSG00000200090 DDB2 MADD MYBPC3 KBTBD4
GH11H047498 1.3 Ensembl ENCODE dbSUPER 10.3 +143.2 143169 1 FOXA2 NFIB TAF1 MAX RAD21 YY1 GATA3 POLR2A HNF4G PRDM10 CELF1 PTPMT1 NDUFS3 RAPSN KBTBD4 RNU5E-10P ENSG00000231880 FAM180B C1QTNF4 MTCH2
GH11H047495 1 ENCODE dbSUPER 10.1 +147.2 147181 0 TBP RFX1 SOX6 CEBPB ZEB2 CEBPG EP300 IRF9 ATF3 IKZF1 RAPSN NDUFS3 RNU5E-10P ENSG00000231880 MTCH2 AGBL2 GC11P047482 ENSG00000270072
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTCH2 on UCSC Golden Path with GeneCards custom track

Promoters for MTCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039718 354 1801 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for MTCH2 Gene

Chromosome:
11
Start:
47,605,204 bp from pter
End:
47,642,654 bp from pter
Size:
37,451 bases
Orientation:
Minus strand

Genomic View for MTCH2 Gene

Genes around MTCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH2 Gene

Proteins for MTCH2 Gene

  • Protein details for MTCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6C9-MTCH2_HUMAN
    Recommended name:
    Mitochondrial carrier homolog 2
    Protein Accession:
    Q9Y6C9
    Secondary Accessions:
    • B2R7L8

    Protein attributes for MTCH2 Gene

    Size:
    303 amino acids
    Molecular mass:
    33331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTCH2 Gene

Post-translational modifications for MTCH2 Gene

  • Ubiquitination at Lys90, posLast=100100, posLast=122122, posLast=293293, and posLast=300300
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MTCH2 Gene

Domains & Families for MTCH2 Gene

Gene Families for MTCH2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MTCH2 Gene

Suggested Antigen Peptide Sequences for MTCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6C9

UniProtKB/Swiss-Prot:

MTCH2_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with MTCH2: view

Function for MTCH2 Gene

Molecular function for MTCH2 Gene

UniProtKB/Swiss-Prot Function:
The substrate transported is not yet known. Induces mitochondrial depolarization.

Phenotypes From GWAS Catalog for MTCH2 Gene

genes like me logo Genes that share phenotypes with MTCH2: view

Animal Models for MTCH2 Gene

MGI Knock Outs for MTCH2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTCH2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTCH2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTCH2 Gene

Localization for MTCH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTCH2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MTCH2: view

Pathways & Interactions for MTCH2 Gene

SuperPathways for MTCH2 Gene

No Data Available

SIGNOR curated interactions for MTCH2 Gene

Activates:

Gene Ontology (GO) - Biological Process for MTCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0043065 positive regulation of apoptotic process IBA --
GO:0070585 protein localization to mitochondrion IMP 23744079
genes like me logo Genes that share ontologies with MTCH2: view

No data available for Pathways by source for MTCH2 Gene

Drugs & Compounds for MTCH2 Gene

No Compound Related Data Available

Transcripts for MTCH2 Gene

Unigene Clusters for MTCH2 Gene

Mitochondrial carrier 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTCH2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MTCH2 Gene

GeneLoc Exon Structure for
MTCH2
ECgene alternative splicing isoforms for
MTCH2

Expression for MTCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MTCH2 Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTCH2 Gene



Protein tissue co-expression partners for MTCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MTCH2 Gene:

MTCH2

SOURCE GeneReport for Unigene cluster for MTCH2 Gene:

Hs.269944

Evidence on tissue expression from TISSUES for MTCH2 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Blood(4.3)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with MTCH2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTCH2 Gene

Orthologs for MTCH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTCH2 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia MTCH2 33
  • 94.33 (n)
-- 34
  • 82 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MTCH2 33 34
  • 92.63 (n)
mouse
(Mus musculus)
Mammalia Mtch2 33 16 34
  • 91.09 (n)
rat
(Rattus norvegicus)
Mammalia Mtch2 33
  • 90.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTCH2 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTCH2 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTCH2 33 34
  • 70.41 (n)
lizard
(Anolis carolinensis)
Reptilia MTCH2 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtch2 33
  • 68.81 (n)
MGC76005 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64562 33
zebrafish
(Danio rerio)
Actinopterygii mtch2 33 34
  • 66.78 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.100 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006963 33
  • 47.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mtch 35 33 34
  • 46.64 (n)
CG10920 35 34
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea mtch-1 33 34
  • 43.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 34
  • 35 (a)
OneToMany
Species where no ortholog for MTCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTCH2 Gene

ENSEMBL:
Gene Tree for MTCH2 (if available)
TreeFam:
Gene Tree for MTCH2 (if available)

Paralogs for MTCH2 Gene

Paralogs for MTCH2 Gene

(2) SIMAP similar genes for MTCH2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MTCH2 Gene

genes like me logo Genes that share paralogs with MTCH2: view

Variants for MTCH2 Gene

Sequence variations from dbSNP and Humsavar for MTCH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000011411 -- 47,605,422(+) GCTGA(-/T)TTTTT utr-variant-3-prime
rs1000040260 -- 47,638,235(+) TTTCC(A/G)TATGT intron-variant
rs1000113549 -- 47,637,849(+) ATTCT(A/C)ATAGC intron-variant
rs1000149005 -- 47,626,712(+) GGTTC(C/T)AGTGA intron-variant
rs1000179993 -- 47,610,391(+) ACTCT(A/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTCH2 Gene

Variant ID Type Subtype PubMed ID
esv1465053 CNV insertion 17803354
esv2744440 CNV deletion 23290073
esv3626206 CNV loss 21293372
esv995881 CNV insertion 20482838
esv998557 CNV insertion 20482838
nsv315 CNV insertion 18451855
nsv469858 CNV gain 16826518
nsv509405 CNV insertion 20534489
nsv69 CNV insertion 15895083
nsv825872 CNV gain 20364138
nsv832142 CNV loss 17160897

Variation tolerance for MTCH2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.52; 88.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTCH2 Gene

Human Gene Mutation Database (HGMD)
MTCH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTCH2 Gene

Disorders for MTCH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MTCH2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search MTCH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MTCH2

Genetic Association Database (GAD)
MTCH2
Human Genome Epidemiology (HuGE) Navigator
MTCH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTCH2
genes like me logo Genes that share disorders with MTCH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTCH2 Gene

Publications for MTCH2 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K … Nakamura Y (Journal of human genetics 2009) 3 22 45 60
  2. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 45 60
  5. Obesity and diabetes genetic variants associated with gestational weight gain. (PMID: 20816152) Stuebe AM … Siega-Riz AM (American journal of obstetrics and gynecology 2010) 3 45 60

Products for MTCH2 Gene

Sources for MTCH2 Gene

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