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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTCH2 Gene

protein-coding   GIFtS: 52
GCID: GC11M048081

mitochondrial carrier 2

(Previous name: mitochondrial carrier homolog 2 (C. elegans) )
 Explore 6 diseases affiliated with
MTCH2 via our new
 Human Malady Compendium 
Biological research products
for MTCH2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Carrier 21 2     Mitochondrial Carrier Homolog 2 (C. Elegans)1
SLC25A501 2     2310034D24Rik2
Met-Induced Mitochondrial Protein2 3     Mitochondrial Carrier Homolog 22
MIMP2 3     Solute Carrier Family 25, Member 502

External Ids:    HGNC: 175871   Entrez Gene: 237882   Ensembl: ENSG000001099197   OMIM: 6132215   UniProtKB: Q9Y6C93   

Export aliases for MTCH2 gene to outside databases

Previous GC identifers: GC11U990208 GC11M048517 GC11M047670 GC11M047604 GC11M047600 GC11M047595 GC11M047639 GC11M047341 GC11M047745


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9
Function: The substrate transported is not yet known. Induces mitochondrial depolarization

Gene Wiki entry for MTCH2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTCH2 gene promoter:
         NF-1   AML1a   Pax-2   MIF-1   Pax-2a   C/EBPalpha   MEF-2A   Pax-3   Pax-2b   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTCH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTCH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

MTCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTCH2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M048081:  view genomic region     (about GC identifiers)

Start:
47,638,858 bp from pter      End:
47,664,206 bp from pter
Size:
25,349 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9 (See protein sequence)
Recommended Name: Mitochondrial carrier homolog 2  
Size: 303 amino acids; 33331 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R7L8

Explore the universe of human proteins at neXtProt for MTCH2: NX_Q9Y6C9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6C9

  • MTCH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055157.1  
    ENSEMBL proteins: 
     ENSP00000303222   ENSP00000432043   ENSP00000432756   ENSP00000439013  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MTCH2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--


    MTCH2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MTCH2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MTCH2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9Y6C9

    ProtoNet protein and cluster: Q9Y6C9

    UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 2 Solcar repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MTCH2_HUMAN, Q9Y6C9
    Function: The substrate transported is not yet known. Induces mitochondrial depolarization

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTCH2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for MTCH2 (Q9Y6C93 ENSP000003032224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ESR1P033723I2D: score=2 
    YWHABP319463I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--


    MTCH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTCH2
    Search CenterWatch for drugs/clinical trials and news about MTCH2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTCH2 gene: 
    NM_014342.3  

    Unigene Cluster for MTCH2:

    Mitochondrial carrier 2
    Hs.269944  [show with all ESTs]
    Unigene Representative Sequence: NM_014342
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539759 ENST00000302503(uc010rho.2 uc010rhp.2) ENST00000534074
    ENST00000531669 ENST00000525649 ENST00000530428 ENST00000530558 ENST00000533571
    ENST00000542981

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MTCH2
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MTCH2 (see all 46):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-219-1-3p hsa-miR-520e hsa-miR-302d hsa-miR-105 hsa-miR-4314 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidMTCH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTCH2 (see all 7)
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    OriGene siRNA: MTCH2
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    Clone
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    Additional cDNA sequence: 

    AF085361.1 AF176008.1 AK223097.1 AK295218.1 AK313032.1 AY380792.1 BC000875.1 

    16 DOTS entries:

    DT.454735  DT.97862134  DT.100805067  DT.100833567  DT.100805069  DT.100805066  DT.92450572  DT.95099612 
    DT.95160519  DT.120745740  DT.92450569  DT.95160524  DT.100810427  DT.92471420  DT.95160523  DT.95202405 

    24/420 AceView cDNA sequences (see all 420):

    BU520979 BG260655 BM760965 BG250559 CR592236 N45249 AF176008 CR618818 
    AY380792 BM666932 BM760118 AF085361 AI207533 Z44944 CR619866 AI860786 
    CA454424 CR606794 AA459948 AI824162 AL546451 BM014004 BM827089 BM695846 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MTCH2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                -                                 
    SP2:                                            -                                   -                                 
    SP3:                                            -                                   -                                 
    SP4:                    -                                                                                             
    SP5:                                                                                -                 -               


    ECgene alternative splicing isoforms for MTCH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTCH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGAGCTCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MTCH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular ProcessBone
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MTCH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTCH2

    SOURCE GeneReport for Unigene cluster: Hs.269944
        SABiosciences Custom PCR Arrays for MTCH2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MTCH2 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MTCH21 mitochondrial carrier 2 70.41(n)
    80.27(a)
      395597  NM_204808.1  NP_990139.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTCH26
    --
    77(a)
    1 ↔ 1
    1(94133737-94146300)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC645622 mitochondrial carrier homolog 2 72.88(n)    BC054302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mtch22 mitochondrial carrier homolog 2 73.67(n)   30655  BC055216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mtch1 , 3 carrier3
    Mitochondrial carrier homolog 11
    38(a)
    (best of 2)3
    46.64(n)1
    40.68(a)1
      61B23
    380261  NM_167800.21  NP_728482.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mtch-11 Protein MTCH-1 43.46(n)
    30.74(a)
      174207  NM_063144.4  NP_495545.3 


    ENSEMBL Gene Tree for MTCH2 (if available)
    TreeFam Gene Tree for MTCH2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTCH2 gene
    MTCH12  
    2 SIMAP similar genes for MTCH2 using alignment to 4 protein entries:     MTCH2_HUMAN (see all proteins):
    PIG60    MTCH1

    MTCH2 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MTCH2
    PGOHUM00000239889 PGOHUM00000248894 PGOHUM00000259140 PGOHUM00000259141 PGOHUM00000237785


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/479 NCBI SNPs in MTCH2 are shown (see all 479    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169564781,2
    F,--47638453(+) ATGGTC/TTCGAA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1484550051,2
    --47638480(+) AACCAC/TCTGCC 1 -- ds50010--------
    rs1427356841,2
    --47638488(+) GCCTCA/GGCCTC 1 -- ds50010--------
    rs2016987691,2
    --47638555(+) ATGGC-/ACCTAC 1 -- ds50010--------
    rs1465200401,2
    --47638628(+) ATGGAA/GGATCA 1 -- ds50010--------
    rs1399472601,2
    --47638634(+) GATCAC/TAGGTA 1 -- ds50010--------
    rs1431891251,2
    --47638905(+) TTTTGG/TGAGAA 1 -- ut310--------
    rs1896804161,2
    --47638953(+) GCAGAC/TAGTAA 1 -- ut310--------
    rs120991301,2
    C,F,A,H,--47639010(+) AGAGAC/AATCAA 1 -- ut3117Minor allele frequency- A:0.10NS EA NA WA 1896
    rs1823117031,2
    --47639030(+) AAGCCA/GAGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MTCH2 (47638858 - 47664206 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for MTCH2
         8 CNVs: 4741 34967 0417 34969 34966 34965 34968 23410
    Human Gene Mutation Database (HGMD): MTCH2

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTCH2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTCH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MTCH2 for disorders           About GeneDecksing

    OMIM gene information: 613221    OMIM disorders: --

    6 diseases for MTCH2:    About MalaCards
    type 2 diabetes mellitus    anorexia nervosa    diabetes mellitus    asthma
    obesity    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: MTCH2 (24 documents)

    Export disorders for MTCH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTCH2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with MTCH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization. (PubMed id 12407445)1, 2 Yerushalmi G.M.... Tsarfaty I. (2002)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    4. Association between obesity and polymorphisms in SEC1 6B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 9 Hotta K....Nakamura Y. (2009)
    5. Molecular basis of the interaction between proapoptoti c truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) pro tein: key players in mitochondrial death pathway. (PubMed id 22416135)1 Katz C....Friedler A. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. The role of obesity-related genetic loci in insulin se nsitivity. (PubMed id 22443470)1 Fall T....Ingelsson E. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. Genetic predictors of weight loss and weight regain af ter intensive lifestyle modification, metformin treatment, or standard care in t he Diabetes Prevention Program. (PubMed id 22179955)1 Delahanty L.M....Franks P.W. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23788 HGNC: 17587 AceView: MTCH2 Ensembl:ENSG00000109919 euGenes: HUgn23788
    ECgene: MTCH2 H-InvDB: MTCH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTCH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTCH2 gene:
    Search GeneIP for patents involving MTCH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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