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Aliases for MTCH1 Gene

Aliases for MTCH1 Gene

  • Mitochondrial Carrier 1 2 3
  • PSAP 3 4 6
  • Presenilin-Associated Protein 3 4
  • Mitochondrial Carrier Homolog 1 (C. Elegans) 2
  • Cell Proliferation-Inducing Protein 60 3
  • Solute Carrier Family 25, Member 49 3
  • Mitochondrial Carrier Homolog 1 3
  • Solute Carrier Family 25 2
  • Member 49 2
  • SLC25A49 3
  • CGI-64 3
  • PIG60 3

External Ids for MTCH1 Gene

Summaries for MTCH1 Gene

Entrez Gene Summary for MTCH1 Gene

  • This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]

GeneCards Summary for MTCH1 Gene

MTCH1 (Mitochondrial Carrier 1) is a Protein Coding gene. Among its related pathways are Hemostasis and Hemostasis. An important paralog of this gene is MTCH2.

UniProtKB/Swiss-Prot for MTCH1 Gene

  • Potential mitochondrial transporter. May play a role in apoptosis.

Gene Wiki entry for MTCH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTCH1 Gene

Genomics for MTCH1 Gene

Genomic Location for MTCH1 Gene

Start:
36,968,135 bp from pter
End:
36,986,551 bp from pter
Size:
18,417 bases
Orientation:
Minus strand

Genomic View for MTCH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTCH1 Gene

Regulatory Elements for MTCH1 Gene

Proteins for MTCH1 Gene

  • Protein details for MTCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZJ7-MTCH1_HUMAN
    Recommended name:
    Mitochondrial carrier homolog 1
    Protein Accession:
    Q9NZJ7
    Secondary Accessions:
    • A8KAX5
    • B2RCE3
    • Q6PK60
    • Q6UX45
    • Q7L465
    • Q9BW23
    • Q9NZR6
    • Q9UJZ5

    Protein attributes for MTCH1 Gene

    Size:
    389 amino acids
    Molecular mass:
    41544 Da
    Quaternary structure:
    • Interacts with PSEN1.
    SequenceCaution:
    • Sequence=AAF07936.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MTCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTCH1 Gene

Proteomics data for MTCH1 Gene at MOPED

Post-translational modifications for MTCH1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys125

Other Protein References for MTCH1 Gene

No data available for DME Specific Peptides for MTCH1 Gene

Domains for MTCH1 Gene

Gene Families for MTCH1 Gene

HGNC:
  • SLC :Solute carriers

Protein Domains for MTCH1 Gene

UniProtKB/Swiss-Prot:

MTCH1_HUMAN
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.:
    • Q9NZJ7
Similarity:
  • Contains 2 Solcar repeats.:
    • Q9NZJ7
genes like me logo Genes that share domains with MTCH1: view

Function for MTCH1 Gene

Molecular function for MTCH1 Gene

UniProtKB/Swiss-Prot Function: Potential mitochondrial transporter. May play a role in apoptosis.

Gene Ontology (GO) - Molecular Function for MTCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10551805
genes like me logo Genes that share ontologies with MTCH1: view

miRNA for MTCH1 Gene

miRTarBase miRNAs that target MTCH1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTCH1 Gene

Localization for MTCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTCH1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTCH1 Gene COMPARTMENTS Subcellular localization image for MTCH1 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MTCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 10551805
GO:0005739 mitochondrion IMP 12377771
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MTCH1: view

Pathways for MTCH1 Gene

genes like me logo Genes that share pathways with MTCH1: view

Pathways by source for MTCH1 Gene

Gene Ontology (GO) - Biological Process for MTCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 12377771
GO:0009966 regulation of signal transduction NAS 10551805
GO:0043065 positive regulation of apoptotic process IEP 12377771
GO:0045161 neuronal ion channel clustering NAS 10551805
genes like me logo Genes that share ontologies with MTCH1: view

Transcripts for MTCH1 Gene

Unigene Clusters for MTCH1 Gene

Mitochondrial carrier 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTCH1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - -
SP9: - - -
SP10: - -
SP11: - - -
SP12: -

ExUns: 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for MTCH1 Gene

GeneLoc Exon Structure for
MTCH1
ECgene alternative splicing isoforms for
MTCH1

Expression for MTCH1 Gene

mRNA expression in normal human tissues for MTCH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTCH1 Gene

SOURCE GeneReport for Unigene cluster for MTCH1 Gene Hs.485262

mRNA Expression by UniProt/SwissProt for MTCH1 Gene

Q9NZJ7-MTCH1_HUMAN
Tissue specificity: Widely expressed with a predominant expression in brain.
genes like me logo Genes that share expressions with MTCH1: view

Orthologs for MTCH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTCH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTCH1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTCH1 36
  • 93.66 (n)
  • 98.71 (a)
MTCH1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTCH1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtch1 36
  • 90.83 (n)
  • 98.2 (a)
Mtch1 16
Mtch1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTCH1 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTCH1 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtch1 36
  • 90.4 (n)
  • 98.2 (a)
chicken
(Gallus gallus)
Aves MTCH1 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTCH1 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20834 36
fruit fly
(Drosophila melanogaster)
Insecta CG10920 37
  • 21 (a)
ManyToMany
Mtch 37
  • 33 (a)
ManyToMany
Mtch 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea mtch-1 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10453 37
  • 35 (a)
OneToMany
Species with no ortholog for MTCH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MTCH1 Gene

ENSEMBL:
Gene Tree for MTCH1 (if available)
TreeFam:
Gene Tree for MTCH1 (if available)

Paralogs for MTCH1 Gene

Paralogs for MTCH1 Gene

Selected SIMAP similar genes for MTCH1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for MTCH1 Gene

genes like me logo Genes that share paralogs with MTCH1: view

Variants for MTCH1 Gene

Sequence variations from dbSNP and Humsavar for MTCH1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11841 -- 36,968,372(+) CCTCA(C/T)ATCAG utr-variant-3-prime
rs697750 -- 36,968,830(+) CGTCT(C/T)GCAGG utr-variant-3-prime, downstream-variant-500B
rs708007 -- 36,976,719(-) CTGGG(C/T)AGGTG intron-variant
rs726819 -- 36,983,434(+) CCAAT(G/T)TCATA intron-variant
rs733461 -- 36,974,707(+) TCTAT(A/G)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTCH1 Gene

Variant ID Type Subtype PubMed ID
nsv885815 CNV Loss 21882294
nsv525288 CNV Loss 19592680
nsv5263 CNV Loss 18451855
esv988069 CNV Deletion 20482838
nsv518386 CNV Gain 19592680
esv21521 CNV Loss 19812545

Relevant External Links for MTCH1 Gene

HapMap Linkage Disequilibrium report
MTCH1

Disorders for MTCH1 Gene

Relevant External Links for MTCH1

Genetic Association Database (GAD)
MTCH1
Human Genome Epidemiology (HuGE) Navigator
MTCH1
genes like me logo Genes that share disorders with MTCH1: view

No data available for UniProtKB/Swiss-Prot for MTCH1 Gene

Publications for MTCH1 Gene

  1. The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. (PMID: 12377771) Xu X. … Cui M.-Z. (J. Biol. Chem. 2002) 2 3 4
  2. Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membrane. (PMID: 17670888) Lamarca V. … Carrodeguas J.A. (Am. J. Physiol., Cell Physiol. 2007) 3 23
  3. Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP. (PMID: 18291114) Mao G. … Xu X. (Biochim. Biophys. Acta 2008) 3 23
  4. Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. (PMID: 10551805) Xu X. … Cui M.-Z. (J. Biol. Chem. 1999) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for MTCH1 Gene

Sources for MTCH1 Gene

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