Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MTCH1 Gene

protein-coding   GIFtS: 52
GCID: GC06M036982

Mitochondrial Carrier 1

(Previous name: mitochondrial carrier homolog 1 (C. elegans))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mitochondrial Carrier 11 2     CGI-642
PSAP2 3 5     PIG602
Presenilin-Associated Protein2 3     SLC25A492
Member 491     Cell Proliferation-Inducing Protein 602
Mitochondrial Carrier Homolog 1 (C. Elegans)1     Mitochondrial Carrier Homolog 12
Solute Carrier Family 251     Solute Carrier Family 25, Member 492

External Ids:    HGNC: 175861   Entrez Gene: 237872   Ensembl: ENSG000001374097   OMIM: 6104495   UniProtKB: Q9NZJ73   

Export aliases for MTCH1 gene to outside databases

Previous GC identifers: GC06M036938 GC06M037043 GC06M036654


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MTCH1 Gene:
This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the
mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak.
Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants
encoding multiple isoforms have been observed. (provided by RefSeq, Oct 2012)

GeneCards Summary for MTCH1 Gene:
MTCH1 (mitochondrial carrier 1) is a protein-coding gene. An important paralog of this gene is MTCH2.

UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7
Function: Potential mitochondrial transporter. May play a role in apoptosis

Gene Wiki entry for MTCH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTCH1 gene promoter:
         Pax-5   MAZR   GCNF   CUTL1   LUN-1   CREB   IRF-2   GCNF-1   deltaCREB   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MTCH1 promoter sequence
   Search Chromatin IP Primers for MTCH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTCH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

MTCH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTCH1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036982:  view genomic region     (about GC identifiers)

Start:
36,935,917 bp from pter      End:
36,954,074 bp from pter
Size:
18,158 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7 (See protein sequence)
Recommended Name: Mitochondrial carrier homolog 1  
Size: 389 amino acids; 41544 Da
Subunit: Interacts with PSEN1
Sequence caution: Sequence=AAF07936.1; Type=Erroneous initiation;
Secondary accessions: A8KAX5 B2RCE3 Q6PK60 Q6UX45 Q7L465 Q9BW23 Q9NZR6 Q9UJZ5
Alternative splicing: 3 isoforms:  Q9NZJ7-1   Q9NZJ7-2   Q9NZJ7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTCH1: NX_Q9NZJ7

Explore proteomics data for MTCH1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys125
  • Modification sites at PhosphoSitePlus

  • See MTCH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258570.1  NP_055156.1  

    ENSEMBL proteins: 
     ENSP00000362718   ENSP00000362730   ENSP00000399187   ENSP00000419739   ENSP00000437660  

    MTCH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MTCH1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MTCH1
    GenScript Custom Purified and Recombinant Proteins Services for MTCH1
    Novus Biologicals MTCH1 Protein
    Novus Biologicals MTCH1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTCH1

     
    Search eBioscience for Proteins for MTCH1 

     
    antibodies-online proteins for MTCH1 (2 products) 

     
    antibodies-online peptides for MTCH1

    MTCH1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MTCH1
    Novus Biologicals MTCH1 Antibodies
    Abcam antibodies for MTCH1
    Cloud-Clone Corp. Antibodies for MTCH1
    Search ThermoFisher Antibodies for MTCH1
    LSBio Antibodies in human, mouse, rat for MTCH1
    antibodies-online antibodies for MTCH1 (26 products) 

    MTCH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTCH1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTCH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTCH1
    Cloud-Clone Corp. CLIAs for MTCH1
    Search eBioscience for ELISAs for MTCH1 
    antibodies-online kits for MTCH1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9NZJ7

    ProtoNet protein and cluster: Q9NZJ7

    UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 2 Solcar repeats


    Find genes that share domains with MTCH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTCH1_HUMAN, Q9NZJ7
    Function: Potential mitochondrial transporter. May play a role in apoptosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10551805
         
    Find genes that share ontologies with MTCH1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTCH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTCH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTCH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTCH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTCH1:
    hsa-mir-124-3p (MIRT022610), hsa-mir-1260b (MIRT052714)

    Block miRNA regulation of human, mouse, rat MTCH1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MTCH1:
    hsa-miR-142-3p hsa-miR-520d-5p hsa-miR-4255 hsa-miR-524-5p hsa-miR-330-3p hsa-miR-580 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidMTCH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTCH1
    Predesigned siRNA for gene silencing in human, mouse, rat MTCH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTCH1

    Clone
    Products:
         
    OriGene clones in human, mouse for MTCH1 (see all 10)
    OriGene ORF clones in mouse, rat for MTCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTCH1 (NM_014341)
    Sino Biological Human cDNA Clone for MTCH1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTCH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTCH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MTCH1_HUMAN, Q9NZJ7: Mitochondrion inner membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS10551805
    GO:0005739mitochondrion IMP12377771
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MTCH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Array including MTCH1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTCH1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MTCH1 (Q9NZJ73 ENSP000003627184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=2 STRING: ENSP00000326366
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP12377771
    GO:0009966regulation of signal transduction NAS10551805
    GO:0043065positive regulation of apoptotic process IEP12377771
    GO:0045161neuronal ion channel clustering NAS10551805

    Find genes that share ontologies with MTCH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTCH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MTCH1 gene (2 alternative transcripts): 
    NM_001271641.1  NM_014341.2  

    Unigene Cluster for MTCH1:

    Mitochondrial carrier 1
    Hs.485262  [show with all ESTs]
    Unigene Representative Sequence: BC040659
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373616(uc003onc.1 uc010jwo.1) ENST00000373627(uc003ond.1)
    ENST00000471737 ENST00000418541 ENST00000460219(uc003one.4 uc011dtt.2)
    ENST00000492754 ENST00000538808
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTCH1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MTCH1:
    hsa-miR-142-3p hsa-miR-520d-5p hsa-miR-4255 hsa-miR-524-5p hsa-miR-330-3p hsa-miR-580 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidMTCH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTCH1
    Predesigned siRNA for gene silencing in human, mouse, rat MTCH1
    Clone
    Products:
         
    OriGene clones in human, mouse for MTCH1 (see all 10)
    OriGene ORF clones in mouse, rat for MTCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTCH1 (NM_014341)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MTCH1
    OriGene qSTAR qPCR primer pairs in human, mouse for MTCH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTCH1
      QuantiTect SYBR Green Assays in human, mouse, rat MTCH1
      QuantiFast Probe-based Assays in human, mouse, rat MTCH1

    Additional mRNA sequence: 

    AF151822.1 AF176006.3 AF189289.1 AF192559.3 AK022783.1 AK130842.1 AK225628.1 AK303318.1 
    AK315067.1 AY358519.1 AY947344.1 BC000702.2 BC006507.2 BC009962.2 BC040659.1 BC110914.1 
    BC125055.1 BC125056.1 BC153873.1 

    Selected DOTS entries (see all 35):

    DT.100039450  DT.320309  DT.100883871  DT.100023468  DT.100883870  DT.100883904  DT.91654661  DT.95141083 
    DT.100883893  DT.95141233  DT.100883884  DT.100039449  DT.100883891  DT.121371871  DT.100660960  DT.100883863 
    DT.100883876  DT.121316273  DT.92459747  DT.95141107  DT.95141205  DT.100651201  DT.100652777  DT.100692464 

    Selected AceView cDNA sequences (see all 1022):

    BQ925131 BM699767 BM802312 AL555903 BQ002829 BM747638 CR591948 BX392921 
    AW182880 AI277972 AA988865 CR615322 CD369815 BM562839 BM696395 CR623607 
    BU859038 CR606325 CA309377 CR606276 BX116380 AW270071 BG057107 BQ959799 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTCH1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
    SP1:              -           -                 -     -                       -                       -     -     -                       -     -     -         
    SP2:              -           -                 -     -     -                 -                       -     -     -                       -     -     -         
    SP3:              -           -                 -     -     -                 -                                   -                       -     -     -         
    SP4:              -           -                 -     -     -                 -                                   -                                             
    SP5:                          -                 -     -     -                 -                                                                                 

    ExUns: 16b · 16c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MTCH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MTCH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAGATTTG
    MTCH1 Expression
    About this image


    MTCH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Ovary (Reproductive System)
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MTCH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTCH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485262

    UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7
    Tissue specificity: Widely expressed with a predominant expression in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including MTCH1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTCH1
    OriGene qSTAR qPCR primer pairs in human, mouse for MTCH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTCH1
    QuantiTect SYBR Green Assays in human, mouse, rat MTCH1
    QuantiFast Probe-based Assays in human, mouse, rat MTCH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MTCH1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtch11 , 5 mitochondrial carrier homolog 1 (C. elegans)1, 5 90.83(n)1
    98.2(a)1
      17 (15.23 cM)5
    564621  NM_019880.31  NP_063933.11 
     293320725 
    chicken
    (Gallus gallus)
    Aves MTCH16
    mitochondrial carrier 1
    73(a)
    1 ↔ 1
    26(1613074-1619777)
    lizard
    (Anolis carolinensis)
    Reptilia MTCH16
    mitochondrial carrier 1
    61(a)
    1 ↔ 1
    4(123731112-123758051)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208342 Xenopus laevis transcribed sequence 84.41(n)    BQ884392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mtch3 carrier 36(a)   61B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea mtch-16
    Protein MTCH-1, isoform a
    23(a)
    1 → many
    II(7372596-7374172) WBGene00018395


    ENSEMBL Gene Tree for MTCH1 (if available)
    TreeFam Gene Tree for MTCH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MTCH1 gene
    MTCH22  
    2 SIMAP similar genes for MTCH1 using alignment to 7 protein entries:     MTCH1_HUMAN (see all proteins):
    PIG60    MTCH2

    Find genes that share paralogs with MTCH1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MTCH1
    PGOHUM00000242184 PGOHUM00000243395


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MTCH1 (see all 516)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122130051,2
    C,H--36935432(+) CACCTC/TGAGCA 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1128535181,2
    C,F--36935608(+) AGCTAC/GGTTAT 2 -- ds50013Minor allele frequency- G:0.03CSA WA 121
    rs1150806231,2
    F--36935611(+) TACGTT/CATCCT 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs777835261,2
    C--36935762(+) ACTGAA/GCTACA 2 -- ds50010--------
    rs1933019751,2
    --36935785(+) ACCTAC/TATCTC 2 -- ds50010--------
    rs789732051,2
    F--36935909(+) CCCCAC/TAAAAA 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1855705561,2
    --36936055(+) TACGCA/GAGGCA 2 -- ut310--------
    rs1904786821,2
    --36936081(+) TGAGCA/GTTAGA 2 -- ut310--------
    rs115485821,2
    C,F,H--36936211(+) ATAGGC/TCTAGA 2 -- ut31 ese35Minor allele frequency- T:0.02NS NA 624
    rs1809307761,2
    --36936253(+) CCCTAC/TGTACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MTCH1 (36935917 - 36954074 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MTCH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv988069CNV Deletion20482838
    esv21521CNV Loss19812545
    nsv525288CNV Loss19592680
    nsv5263CNV Loss18451855
    nsv885815CNV Loss21882294
    nsv518386CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTCH1
    DNA2.0 Custom Variant and Variant Library Synthesis for MTCH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610449    OMIM disorders: --


    Find genes that share disorders with MTCH1           About GenesLikeMe

    Genetic Association Database (GAD): MTCH1
    Human Genome Epidemiology (HuGE) Navigator: MTCH1 (2 documents)

    Export disorders for MTCH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MTCH1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with MTCH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. (PubMed id 12377771)1, 2, 3 Xu X.... Cui M.-Z. (J. Biol. Chem. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. (PubMed id 10551805)1, 2 Xu X.... Cui M.-Z. (J. Biol. Chem. 1999)
    9. Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membrane. (PubMed id 17670888)1, 9 Lamarca V....Carrodeguas J.A. (Am. J. Physiol., Cell Physiol. 2007)
    10. Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP. (PubMed id 18291114)1, 9 Mao G....Xu X. (Biochim. Biophys. Acta 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23787 HGNC: 17586 AceView: MTCH1 Ensembl:ENSG00000137409 euGenes: HUgn23787
    ECgene: MTCH1 H-InvDB: MTCH1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MTCH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MTCH1 gene:
    Search GeneIP for patents involving MTCH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MTCH1  
     OriGene qPCR primer pairs and template standards for MTCH1   OriGene Protein Over-expression Lysate for MTCH1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MTCH1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MTCH1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MTCH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTCH1   OriGene Custom Protein Services for MTCH1  

     
     
     Block miRNA regulation of human, mouse, rat MTCH1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MTCH1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTCH1 Predesigned siRNA for gene silencing in human, mouse, rat MTCH1
     QuantiFast Probe-based Assays in human, mouse, rat MTCH1 QuantiTect SYBR Green Assays in human, mouse, rat MTCH1
     PCR Arrays including human, mouse, rat MTCH1 Search Chromatin IP Primers for MTCH1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTCH1  GeneGlobe Interaction Network for MTCH1
     Regulatory tfbs in MTCH1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MTCH1 GenScript cDNA clones with any tag delivered in your preferred vector for MTCH1
     GenScript Custom Assay Services for MTCH1 GenScript Custom overexpressing Cell Line Services for MTCH1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MTCH1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MTCH1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MTCH1 antibodies
     MTCH1 proteins
     MTCH1 lysates
     Antibodies for MTCH1
     See all of Abcam's Antibodies, Kits and Proteins for MTCH1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MTCH1
     Antibodies for MTCH1
     ELISAs for MTCH1
     CLIAs for MTCH1



     Browse ESI BIO Cell Lines and PureStem Progenitors for MTCH1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH1
     SwitchGear 3'UTR luciferase reporter plasmids for MTCH1
     SwitchGear Promoter luciferase reporter plasmids for MTCH1
     Search ThermoFisher Antibodies for MTCH1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTCH1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTCH1
     LSBio Antibodies in human, mouse, rat for MTCH1
     Browse compounds at ApexBio
     Search Addgene for plasmids for MTCH1
      Search eBioscience for proteins for MTCH1
      Search eBioscience for elisas for MTCH1
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for MTCH1 (26 products)
     antibodies-online kits for MTCH1 (2 products)
     antibodies-online peptides for MTCH1
     antibodies-online proteins for MTCH1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTCH1 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4