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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTCH1 Gene

protein-coding   GIFtS: 51
GCID: GC06M036982

Mitochondrial Carrier 1

(Previous name: mitochondrial carrier homolog 1 (C. elegans))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Carrier 11 2     CGI-642
Presenilin-Associated Protein2 3     PIG602
PSAP2 3     SLC25A492
Member 491     Cell Proliferation-Inducing Protein 602
Mitochondrial Carrier Homolog 1 (C. Elegans)1     Mitochondrial Carrier Homolog 12
Solute Carrier Family 251     Solute Carrier Family 25, Member 492

External Ids:    HGNC: 175861   Entrez Gene: 237872   Ensembl: ENSG000001374097   OMIM: 6104495   UniProtKB: Q9NZJ73   

Export aliases for MTCH1 gene to outside databases

Previous GC identifers: GC06M036938 GC06M037043 GC06M036654


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTCH1 Gene:
This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the
mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak.
Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants
encoding multiple isoforms have been observed. (provided by RefSeq, Oct 2012)

GeneCards Summary for MTCH1 Gene: 
MTCH1 (mitochondrial carrier 1) is a protein-coding gene. Diseases associated with MTCH1 include neuronitis. GO annotations related to this gene include protein binding. An important paralog of this gene is MTCH2.

UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7
Function: Potential mitochondrial transporter. May play a role in apoptosis

Gene Wiki entry for MTCH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTCH1 gene promoter:
         Pax-5   MAZR   GCNF   CUTL1   LUN-1   CREB   IRF-2   GCNF-1   deltaCREB   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MTCH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MTCH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTCH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

MTCH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTCH1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M036982:  view genomic region     (about GC identifiers)

Start:
36,935,917 bp from pter      End:
36,954,074 bp from pter
Size:
18,158 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7 (See protein sequence)
Recommended Name: Mitochondrial carrier homolog 1  
Size: 389 amino acids; 41544 Da
Subunit: Interacts with PSEN1
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF07936.1; Type=Erroneous initiation;
Secondary accessions: A8KAX5 B2RCE3 Q6PK60 Q6UX45 Q7L465 Q9BW23 Q9NZR6 Q9UJZ5
Alternative splicing: 3 isoforms:  Q9NZJ7-1   Q9NZJ7-2   Q9NZJ7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MTCH1: NX_Q9NZJ7

Explore proteomics data for MTCH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZJ7

  • MTCH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTCH1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258570.1  NP_055156.1  

    ENSEMBL proteins: 
     ENSP00000362718   ENSP00000362730   ENSP00000399187   ENSP00000419739   ENSP00000437660  

    Human Recombinant Protein Products for MTCH1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTCH1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS10551805
    GO:0005739mitochondrion IMP12377771
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--

    MTCH1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    2 InterPro protein domains:
     IPR023395 Mt_carrier_dom
     IPR018108 Mitochondrial_sb/sol_carrier

    Graphical View of Domain Structure for InterPro Entry Q9NZJ7

    ProtoNet protein and cluster: Q9NZJ7

    UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7
    Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family
    Similarity: Contains 2 Solcar repeats


    MTCH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTCH1_HUMAN, Q9NZJ7
    Function: Potential mitochondrial transporter. May play a role in apoptosis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10551805
         
    MTCH1 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTCH1 
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    SwitchGear 3'UTR luciferase reporter plasmidMTCH1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTCH1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for MTCH1 (Q9NZJ73 ENSP000003627184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=2 STRING: ENSP00000326366
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    YWHABP319463I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP12377771
    GO:0009966regulation of signal transduction NAS10551805
    GO:0043065positive regulation of apoptotic process IEP12377771
    GO:0045161neuronal ion channel clustering NAS10551805

    MTCH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTCH1

    Search CenterWatch for drugs/clinical trials and news about MTCH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTCH1 gene (2 alternative transcripts): 
    NM_001271641.1  NM_014341.2  

    Unigene Cluster for MTCH1:

    Mitochondrial carrier 1
    Hs.485262  [show with all ESTs]
    Unigene Representative Sequence: BC040659
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373616(uc003onc.1 uc010jwo.1) ENST00000373627(uc003ond.1)
    ENST00000471737 ENST00000418541 ENST00000460219(uc003one.4 uc011dtt.2)
    ENST00000492754 ENST00000538808
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MTCH1:
    hsa-miR-142-3p hsa-miR-520d-5p hsa-miR-4255 hsa-miR-524-5p hsa-miR-330-3p hsa-miR-580 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidMTCH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTCH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTCH1
    Sirion Biotech Customized lentivirus for stable overexpression of MTCH1 
                         Customized lentivirus expression plasmids for stable overexpression of MTCH1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTCH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTCH1

    Additional mRNA sequence: 

    AF151822.1 AF176006.3 AF189289.1 AF192559.3 AK022783.1 AK130842.1 AK225628.1 AK303318.1 
    AK315067.1 AY358519.1 AY947344.1 BC000702.2 BC006507.2 BC009962.2 BC040659.1 BC110914.1 
    BC125055.1 BC125056.1 BC153873.1 

    24/35 DOTS entries (see all 35):

    DT.100039450  DT.320309  DT.100883871  DT.100023468  DT.100883870  DT.100883904  DT.91654661  DT.95141083 
    DT.100883893  DT.95141233  DT.100883884  DT.100039449  DT.100883891  DT.121371871  DT.100660960  DT.100883863 
    DT.100883876  DT.121316273  DT.92459747  DT.95141107  DT.95141205  DT.100651201  DT.100652777  DT.100692464 

    24/1022 AceView cDNA sequences (see all 1022):

    CR605558 BG820691 CR601627 BX392921 AW410004 BM452355 CR603921 CD360022 
    CR592724 CR614276 BQ956597 BG762559 BE385628 BE315275 BG328595 CR594379 
    BU182592 BE617062 CD369815 BQ925131 BQ899172 BQ432447 AW182880 AI277972 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MTCH1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
    SP1:              -           -                 -     -                       -                       -     -     -                       -     -     -         
    SP2:              -           -                 -     -     -                 -                       -     -     -                       -     -     -         
    SP3:              -           -                 -     -     -                 -                                   -                       -     -     -         
    SP4:              -           -                 -     -     -                 -                                   -                                             
    SP5:                          -                 -     -     -                 -                                                                                 

    ExUns: 16b · 16c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MTCH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTCH1 expression in normal human tissues (normalized intensities)      MTCH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAGATTTG
    MTCH1 Expression
    About this image


    MTCH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             salivary gland   

    See MTCH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTCH1

    SOURCE GeneReport for Unigene cluster: Hs.485262

    UniProtKB/Swiss-Prot: MTCH1_HUMAN, Q9NZJ7
    Tissue specificity: Widely expressed with a predominant expression in brain

        SABiosciences Expression via Pathway-Focused PCR Array including MTCH1: 
              Apoptosis 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTCH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MTCH1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtch11 , 5 mitochondrial carrier homolog 1 (C. elegans)1, 5 90.41(n)1
    98.12(a)1
      17 (15.23 cM)5
    564621  NM_019880.31  NP_063933.11 
     293320725 
    chicken
    (Gallus gallus)
    Aves MTCH11 mitochondrial carrier 1 74.81(n)
    77.17(a)
      425491  XM_423245.3  XP_423245.2 
    lizard
    (Anolis carolinensis)
    Reptilia MTCH16
    mitochondrial carrier 1
    61(a)
    1 ↔ 1
    4(123731112-123758051)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208342 Xenopus laevis transcribed sequence 84.41(n)    BQ884392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mtch3 carrier 36(a)   61B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea mtch-16
    Protein MTCH-1, isoform a
    23(a)
    1 → many
    II(7372596-7374174)


    ENSEMBL Gene Tree for MTCH1 (if available)
    TreeFam Gene Tree for MTCH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTCH1 gene
    MTCH22  
    2 SIMAP similar genes for MTCH1 using alignment to 7 protein entries:     MTCH1_HUMAN (see all proteins):
    PIG60    MTCH2

    MTCH1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MTCH1
    PGOHUM00000242184 PGOHUM00000243395


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/516 SNPs in MTCH1 are shown (see all 516)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122130051,2
    C,H--36935432(+) CACCTC/TGAGCA 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1128535181,2
    C,F--36935608(+) AGCTAC/GGTTAT 2 -- ds50013Minor allele frequency- G:0.03CSA WA 121
    rs1150806231,2
    F--36935611(+) TACGTT/CATCCT 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs777835261,2
    C--36935762(+) ACTGAA/GCTACA 2 -- ds50010--------
    rs1933019751,2
    --36935785(+) ACCTAC/TATCTC 2 -- ds50010--------
    rs789732051,2
    F--36935909(+) CCCCAC/TAAAAA 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1855705561,2
    --36936055(+) TACGCA/GAGGCA 2 -- ut310--------
    rs1904786821,2
    --36936081(+) TGAGCA/GTTAGA 2 -- ut310--------
    rs115485821,2
    C,F,H--36936211(+) ATAGGC/TCTAGA 2 -- ut31 ese35Minor allele frequency- T:0.02NS NA 624
    rs1809307761,2
    --36936253(+) CCCTAC/TGTACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MTCH1 (36935917 - 36954074 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MTCH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv988069CNV Deletion20482838
    esv21521CNV Loss19812545
    nsv525288CNV Loss19592680
    nsv5263CNV Loss18451855
    nsv885815CNV Loss21882294
    nsv518386CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610449    OMIM disorders: --

    2 diseases for MTCH1:    About MalaCards
    neuronitis    


    MTCH1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTCH1
    Human Genome Epidemiology (HuGE) Navigator: MTCH1 (2 documents)

    Export disorders for MTCH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTCH1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with MTCH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. (PubMed id 12377771)1, 2, 3 Xu X.... Cui M.-Z. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. (PubMed id 10551805)1, 2 Xu X.... Cui M.-Z. (1999)
    9. Two isoforms of PSAP/MTCH1 share two proapoptotic domains and multiple internal signals for import into the mitochondrial outer membrane. (PubMed id 17670888)1, 9 Lamarca V....Carrodeguas J.A. (2007)
    10. Both the N-terminal fragment and the protein-protein interaction domain (PDZ domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP. (PubMed id 18291114)1, 9 Mao G....Xu X. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23787 HGNC: 17586 AceView: MTCH1 Ensembl:ENSG00000137409 euGenes: HUgn23787
    ECgene: MTCH1 H-InvDB: MTCH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTCH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MTCH1 gene:
    Search GeneIP for patents involving MTCH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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