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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTBP Gene

protein-coding   GIFtS: 48
GCID: GC08P121526

Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding...

(Previous names: MDM2 (mouse double minute 2)-binding protein, 104kD)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse)
Binding Protein, 104kDa1 2
MDM2 (Mouse Double Minute 2)-Binding Protein, 104kD1 2
MDM2BP2
Mdm2-Binding Protein2
hMTBP3

External Ids:    HGNC: 74171   Entrez Gene: 270852   Ensembl: ENSG000001721677   OMIM: 6059275   UniProtKB: Q96DY73   

Export aliases for MTBP gene to outside databases

Previous GC identifers: GC08P120426 GC08P121515 GC08P121126 GC08P121414 GC08P116778


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTBP Gene:
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein
regulates progression through the cell cycle and may be involved in tumor formation. (provided by RefSeq, Aug
2012)

GeneCards Summary for MTBP Gene: 
MTBP (Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa) is a protein-coding gene. Diseases associated with MTBP include squamous cell carcinoma.

UniProtKB/Swiss-Prot: MTBP_HUMAN, Q96DY7
Function: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity).
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2,
thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTBP gene promoter:
         p53   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   FOXL1   HEN1   Pax-2b   STAT3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTBP promoter sequence
   Search SABiosciences Chromatin IP Primers for MTBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24.1-q24.2

MTBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTBP gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P121526:  view genomic region     (about GC identifiers)

Start:
121,457,640 bp from pter      End:
121,554,373 bp from pter
Size:
96,734 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTBP_HUMAN, Q96DY7 (See protein sequence)
Recommended Name: Mdm2-binding protein  
Size: 904 amino acids; 102193 Da
Subunit: Interacts with MDM2
Sequence caution: Sequence=BAB13965.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result
from internal priming due to genomic poly-A tracts; Sequence=EAW92007.1; Type=Erroneous gene model prediction;
Secondary accessions: Q9HA89

Explore the universe of human proteins at neXtProt for MTBP: NX_Q96DY7

Explore proteomics data for MTBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DY7

  • MTBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTBP Protein Expression
    REFSEQ proteins: NP_071328.2  
    ENSEMBL proteins: 
     ENSP00000430771   ENSP00000303398   ENSP00000428574  

    Human Recombinant Protein Products for MTBP: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96DY7

    UniProtKB/Swiss-Prot: MTBP_HUMAN, Q96DY7
    Similarity: Belongs to the MTBP family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTBP_HUMAN, Q96DY7
    Function: Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity).
    May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2,
    thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent
    degradation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    MTBP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MTBP:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mtbp):
     mortality/aging  tumorigenesis 

    MTBP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MTBP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MTBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTBP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTBP 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MTBP:
    hsa-miR-3163
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    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTBP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTBP

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MTBP (Q96DY73 ENSP000003033984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=3 STRING: ENSP00000417281
    SUMO1ENSP000003760764STRING: ENSP00000376076
    MDM4ENSP000003561504STRING: ENSP00000356150
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--
    GO:0007089traversing start control point of mitotic cell cycle IEA--
    GO:0008285negative regulation of cell proliferation IEA--

    MTBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTBP

    Search CenterWatch for drugs/clinical trials and news about MTBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MTBP gene: 
    NM_022045.4  

    Unigene Cluster for MTBP:

    Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
    Hs.657656  [show with all ESTs]
    Unigene Representative Sequence: AL832671
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456899 ENST00000522308(uc003ypb.1) ENST00000523373 ENST00000305949(uc011lie.1 uc003ypc.1)
    ENST00000522449 ENST00000519188 ENST00000519556 ENST00000519841
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MTBP:
    hsa-miR-3163
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MTBP (NM_022045)
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                         Customized lentivirus expression plasmids for stable overexpression of MTBP 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTBP

    Additional mRNA sequence: 

    AK300762.1 AL832671.1 BC013136.1 

    10 DOTS entries:

    DT.75132405  DT.40131241  DT.107667  DT.65284101  DT.99956294  DT.107668  DT.121480722  DT.65285223 
    DT.100725890  DT.91754158 

    24/53 AceView cDNA sequences (see all 53):

    AA780214 BQ353302 AW015671 BF509688 BC013136 AI939556 NM_022045 AI369856 
    AI336784 BI462049 BF665037 AI619934 AA319025 AI251755 BG254784 BU753139 
    CA395560 BF591612 BX495124 N94844 AA071350 AL832671 AK130778 AU121128 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MTBP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for MTBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTBP expression in normal human tissues (normalized intensities)      MTBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACATCCAG
    MTBP Expression
    About this image


    MTBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone

    See MTBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTBP

    SOURCE GeneReport for Unigene cluster: Hs.657656
        SABiosciences Custom PCR Arrays for MTBP
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MTBP gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mtbp1 , 5 Mdm2, transformed 3T3 cell double minute p53 binding more1, 5 80.59(n)1
    78.05(a)1
      15 (22.05 cM)5
    1058371  NM_134092.31  NP_598853.31 
     555574085 
    chicken
    (Gallus gallus)
    Aves MTBP1 Mdm2, transformed 3T3 cell double minute 2, p53 binding more 67.08(n)
    62.15(a)
      420354  XM_418460.3  XP_418460.3 
    lizard
    (Anolis carolinensis)
    Reptilia MTBP6
    Mdm2, transformed 3T3 cell double minute 2, p53 bi...
    53(a)
    1 ↔ 1
    GL343269.1(1427469-1464091)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55512 Xenopus laevis transcribed sequences 75.21(n)    BX853361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.277272 Transcribed sequence 71.29(n)    57078594 


    ENSEMBL Gene Tree for MTBP (if available)
    TreeFam Gene Tree for MTBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1479 SNPs in MTBP are shown (see all 1479)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2014840571,2
    C--116826407(+) TATAA-/TTTTTT 1 -- int10--------
    rs1474267661,2
    C--116839538(+) CCGAC-/TGTGCTT 1 -- int10--------
    rs1999248231,2
    C--116839540(+) GACTG-/TGCTTTTT 1 -- int10--------
    rs339905251,2
    C--116840900(+) TTTTA-/GCAGAA 1 -- int10--------
    rs1437500181,2
    C--116845451(+) TTATC-/AAAATA 1 -- int10--------
    rs1121951891,2
    C,F--116854871(+) TAATGG/CAGCAT 1 -- int12Minor allele frequency- C:0.50NA 4
    rs58945221,2
    C--121460106(+) gaaca-/TCTTT 
            
    tcttt
    1 -- int10--------
    rs359042031,2
    C--121460107(+) CTTTT-/CTTT  
     T
    /TCTTT
    ATTGG
    1 -- int11NA 2
    rs590819661,2
    C--121460166(+) TTTTTT/-CTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs339590121,2
    C--121465070(+) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for MTBP (121457640 - 121554373 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for MTBP (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1445617CNV Deletion17803354
    esv1399764CNV Deletion17803354
    dgv1270e201CNV Deletion23290073
    dgv1269e201CNV Deletion23290073
    esv2737492CNV Deletion23290073
    esv2737493CNV Deletion23290073
    esv2737501CNV Deletion23290073
    esv2737503CNV Deletion23290073
    nsv6366CNV Loss18451855
    nsv819372CNV Loss19587683

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605927    OMIM disorders: --

    2 diseases for MTBP:    About MalaCards
    squamous cell carcinoma    


    MTBP for disorders           About GeneDecksing

    Genetic Association Database (GAD): MTBP

    Export disorders for MTBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTBP gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MTBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of p53 and MDM2 activity by MTBP. (PubMed id 15632057)1, 2 Brady M.... Boyd M.T. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization. (PubMed id 11060448)1, 3 Boyd M.T....Haines D.S. (2000)
    4. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. (PubMed id 10906133)1, 3 Boyd M.T....Haines D.S. (2000)
    5. MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4. (PubMed id 22370640)1 Agarwal N....Iwakuma T. (2013)
    6. Identification of a heteromeric complex that promotes DNA replication origin firing in human cells. (PubMed id 23704573)1 Boos D....Diffley J.F. (2013)
    7. MDM2 binding protein, a novel metastasis suppressor. (PubMed id 22684342)1 Iwakuma T. and Agarwal N. (2012)
    8. MTBP plays a crucial role in mitotic progression and chromosome segregation. (PubMed id 21274008)1 Agarwal N....Iwakuma T. (2011)
    9. Loss of MTBP expression is associated with reduced su rvival in a biomarker-defined subset of patients with squamous cell carcinoma o f the head and neck. (PubMed id 21692053)1 VlatkoviA8 N....Boyd M.T. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27085 HGNC: 7417 AceView: MTBP Ensembl:ENSG00000172167 euGenes: HUgn27085
    ECgene: MTBP H-InvDB: MTBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTBP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTBP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for MTBP gene:
    Search GeneIP for patents involving MTBP

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