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Aliases for MTBP Gene

Aliases for MTBP Gene

  • MDM2 Binding Protein 2 3 5
  • MDM2 (Mouse Double Minute 2)-Binding Protein, 104kD 2 3
  • Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) Binding Protein, 104kDa 2
  • Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein Binding Protein, 104kDa 3
  • Mdm2-Binding Protein 3
  • MDM2BP 3
  • HMTBP 4

External Ids for MTBP Gene

Previous GeneCards Identifiers for MTBP Gene

  • GC08P121515
  • GC08P121126
  • GC08P121414
  • GC08P121526
  • GC08P116778
  • GC08P121458

Summaries for MTBP Gene

Entrez Gene Summary for MTBP Gene

  • This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]

GeneCards Summary for MTBP Gene

MTBP (MDM2 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MTBP Gene

  • Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTBP Gene

Genomics for MTBP Gene

Regulatory Elements for MTBP Gene

Enhancers for MTBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G120443 1.5 FANTOM5 ENCODE 24.2 -0.4 -425 2.6 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MTBP MRPL13 SNTB1 PIR54850
GH08G120529 0.8 Ensembl ENCODE 33.5 +84.7 84688 1.8 PAF1 SSRP1 POLR2A SMARCA4 MAFK MTBP MRPL13 NCAPGP1
GH08G119968 1.4 Ensembl ENCODE dbSUPER 10.9 -471.1 -471130 11.1 HDGF PKNOX1 FOXA2 ZFP64 FEZF1 RAD21 RFX5 YY1 ZNF121 HSF1 DEPTOR TAF2 COL14A1 MTBP DSCC1 ENSG00000254343 ENSG00000245330 GC08M119936 GC08P120015
GH08G119914 1.4 Ensembl ENCODE dbSUPER 10.8 -528.8 -528789 3.7 PKNOX1 FOXA2 INSM2 KLF17 FEZF1 RAD21 RARA YY1 TCF12 ZNF366 DSCC1 TAF2 DEPTOR ENSG00000245330 MTBP PIR41964 GC08M119936
GH08G120472 0.6 ENCODE 23.1 +27.2 27158 0.2 GATAD2A HLF CEBPB HMG20A CEBPG IRF9 CEBPA TCF7 MTBP MRPL13 NCAPGP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTBP on UCSC Golden Path with GeneCards custom track

Genomic Location for MTBP Gene

Chromosome:
8
Start:
120,445,398 bp from pter
End:
120,542,133 bp from pter
Size:
96,736 bases
Orientation:
Plus strand

Genomic View for MTBP Gene

Genes around MTBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTBP Gene

Proteins for MTBP Gene

  • Protein details for MTBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DY7-MTBP_HUMAN
    Recommended name:
    Mdm2-binding protein
    Protein Accession:
    Q96DY7
    Secondary Accessions:
    • B4DUR5
    • Q9HA89

    Protein attributes for MTBP Gene

    Size:
    904 amino acids
    Molecular mass:
    102193 Da
    Quaternary structure:
    • Interacts with MDM2.
    SequenceCaution:
    • Sequence=BAB13965.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.; Evidence={ECO:0000305}; Sequence=EAW92007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MTBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTBP Gene

Post-translational modifications for MTBP Gene

  • Ubiquitination at Lys630
  • Modification sites at PhosphoSitePlus

Other Protein References for MTBP Gene

No data available for DME Specific Peptides for MTBP Gene

Domains & Families for MTBP Gene

Protein Domains for MTBP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96DY7

UniProtKB/Swiss-Prot:

MTBP_HUMAN :
  • Belongs to the MTBP family.
Family:
  • Belongs to the MTBP family.
genes like me logo Genes that share domains with MTBP: view

No data available for Gene Families for MTBP Gene

Function for MTBP Gene

Molecular function for MTBP Gene

UniProtKB/Swiss-Prot Function:
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
genes like me logo Genes that share phenotypes with MTBP: view

Animal Models for MTBP Gene

MGI Knock Outs for MTBP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTBP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MTBP Gene

Localization for MTBP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTBP gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MTBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 21274008
GO:0000785 chromatin IDA 21274008
genes like me logo Genes that share ontologies with MTBP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MTBP Gene

Pathways & Interactions for MTBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0007089 traversing start control point of mitotic cell cycle IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0034501 protein localization to kinetochore IMP 21274008
genes like me logo Genes that share ontologies with MTBP: view

No data available for Pathways by source and SIGNOR curated interactions for MTBP Gene

Drugs & Compounds for MTBP Gene

No Compound Related Data Available

Transcripts for MTBP Gene

Unigene Clusters for MTBP Gene

Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTBP

Alternative Splicing Database (ASD) splice patterns (SP) for MTBP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for MTBP Gene

GeneLoc Exon Structure for
MTBP
ECgene alternative splicing isoforms for
MTBP

Expression for MTBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTBP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.7) and Brain - Cerebellum (x4.6).

Protein differential expression in normal tissues from HIPED for MTBP Gene

This gene is overexpressed in Plasma (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTBP Gene



Protein tissue co-expression partners for MTBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MTBP Gene:

MTBP

SOURCE GeneReport for Unigene cluster for MTBP Gene:

Hs.657656
genes like me logo Genes that share expression patterns with MTBP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTBP Gene

Orthologs for MTBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MTBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTBP 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia MTBP 34 35
  • 89.79 (n)
cow
(Bos Taurus)
Mammalia MTBP 34 35
  • 85.21 (n)
rat
(Rattus norvegicus)
Mammalia Mtbp 34
  • 81.45 (n)
mouse
(Mus musculus)
Mammalia Mtbp 34 16 35
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia MTBP 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves MTBP 35 34
  • 66.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTBP 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtbp 34
  • 60.89 (n)
Str.16675 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5551 34
zebrafish
(Danio rerio)
Actinopterygii LOC100534898 34
  • 53.37 (n)
MTBP 35
  • 45 (a)
OneToOne
Dr.27727 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1979 34
Species where no ortholog for MTBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTBP Gene

ENSEMBL:
Gene Tree for MTBP (if available)
TreeFam:
Gene Tree for MTBP (if available)

Paralogs for MTBP Gene

No data available for Paralogs for MTBP Gene

Variants for MTBP Gene

Sequence variations from dbSNP and Humsavar for MTBP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs193921136 Uncertain significance 120,517,984(+) TTCCA(A/G/T)TTCCT reference, missense
rs1000057682 -- 120,502,398(+) ACACA(C/T)ACACG intron-variant
rs1000082843 -- 120,483,270(+) GTGAT(C/G)TCATT intron-variant
rs1000109635 -- 120,501,800(+) TTATA(A/T)TAATT intron-variant
rs1000133911 -- 120,468,312(+) TCAGA(C/T)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTBP Gene

Variant ID Type Subtype PubMed ID
dgv1217e201 CNV deletion 23290073
dgv1218e201 CNV deletion 23290073
esv1399764 CNV deletion 17803354
esv1445617 CNV deletion 17803354
esv2737492 CNV deletion 23290073
esv2737493 CNV deletion 23290073
esv2737501 CNV deletion 23290073
esv2737503 CNV deletion 23290073
esv3544112 CNV deletion 23714750
esv3618609 CNV loss 21293372
esv3618610 CNV loss 21293372
nsv470235 CNV loss 18288195
nsv519152 CNV gain 19592680
nsv6366 CNV deletion 18451855
nsv819372 CNV loss 19587683
nsv956086 CNV deletion 24416366

Variation tolerance for MTBP Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTBP Gene

Human Gene Mutation Database (HGMD)
MTBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTBP Gene

Disorders for MTBP Gene

Relevant External Links for MTBP

Genetic Association Database (GAD)
MTBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTBP

No disorders were found for MTBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTBP Gene

Publications for MTBP Gene

  1. Regulation of p53 and MDM2 activity by MTBP. (PMID: 15632057) Brady M. … Boyd M.T. (Mol. Cell. Biol. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. (PMID: 10906133) Boyd M.T. … Haines D.S. (J. Biol. Chem. 2000) 2 3 64
  4. Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization. (PMID: 11060448) Boyd M.T. … Haines D.S. (Cytogenet. Cell Genet. 2000) 2 3 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for MTBP Gene

Sources for MTBP Gene

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