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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MTA3 Gene

protein-coding GIFtS: 56
GCID: GC02P042722

Metastasis Associated 1 Family, Member 3

(Previous names: metastasis associated gene family, member 3)

4 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Metastasis Associated 1 Family, Member 3¹ ²
Metastasis Associated Gene Family, Member 3¹ ²
Metastasis Associated Family, Member 3²
Metastasis-Associated Protein MTA3²
KIAA1266³

External Ids:	HGNC: 23784¹	Entrez Gene: 57504²	Ensembl: ENSG00000057935⁷	OMIM: 609050⁵	UniProtKB: Q9BTC8³

Export aliases for MTA3 gene to outside databases

Previous GC identifers: GC02P042783 GC02P042963 GC02P042770 GC02P042696 GC02P042633 GC02P042577 GC02P042649

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MTA3 Gene:

MTA3 (metastasis associated 1 family, member 3) is a protein-coding gene. Diseases associated with MTA3 include b-cell lymphomas, and breast cancer, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8

Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1

transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels

Gene Wiki entry for MTA3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_022184.15 NC_018913.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MTA3 gene promoter:
ER-alpha ISGF-3 AML1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) STAT5A POU3F2 Evi-1 FOXL1 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MTA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p22.1

MTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTA3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P042722: view genomic region (about GC identifiers)

Start:	42,721,709 bp from pter	End:	42,984,087 bp from pter
Size:	262,379 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8 (See protein sequence)

Recommended Name: Metastasis-associated protein MTA3

Size: 594 amino acids; 67504 Da

Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD)

Subcellular location: Nucleus

Sequence caution: Sequence=BAA86580.1; Type=Erroneous initiation;

Secondary accessions: Q9NSP2 Q9ULF4

Alternative splicing: 2 isoforms: Q9BTC8-1 Q9BTC8-2

Explore the universe of human proteins at neXtProt for MTA3: NX_Q9BTC8

Explore proteomics data for MTA3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BTC8

MTA3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001269684.1 NP_001269685.1 NP_065795.1

ENSEMBL proteins:

ENSP00000383973 ENSP00000384249 ENSP00000385045 ENSP00000391455 ENSP00000385241

ENSP00000386763 ENSP00000401815 ENSP00000385823 ENSP00000388722

Human Recombinant Protein Products for MTA3:

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	OriGene Purified Protein for MTA3 OriGene Protein Over-expression Lysate for MTA3 OriGene MassSpec for MTA3 OriGene Custom Protein Services for MTA3
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	Novus Biologicals MTA3 Proteins Novus Biologicals MTA3 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MTA3

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0008278	cohesin complex	IEA	--
GO:0016581	NuRD complex	IEA	--

MTA3 for ontologies About GeneDecksing

MTA3 Antibody Products:

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Assay Products for MTA3:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

GATAD: GATA zinc finger domain containing

5/6 InterPro protein domains (see all 6):

IPR017884 SANT_dom

IPR001005 SANT/Myb

IPR001025 BAH_dom

IPR000679 Znf_GATA

IPR000949 ELM2_dom

Graphical View of Domain Structure for InterPro Entry Q9BTC8

ProtoNet protein and cluster: Q9BTC8

3 Blocks protein domains:

IPB000679 Zn-finger

IPB000949 ELM2 domain

IPB001025 Bromo adjacent region

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8

Similarity: Contains 1 BAH domain

Similarity: Contains 1 ELM2 domain

Similarity: Contains 1 GATA-type zinc finger

Similarity: Contains 1 SANT domain

MTA3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MTA3_HUMAN, Q9BTC8

Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1

transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels

Induction: By estrogen

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	18451880
GO:0008270	zinc ion binding	IEA	--

MTA3 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mta3):

behavior/neurological

homeostasis/metabolism

immune system

MTA3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for MTA3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MTA3

miRNA Products:
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate MTA3:
		hsa-miR-495
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MTA3 About

See pathways by source

SuperPath

Contained pathways About

Development NOTCH1-mediated pathway for NF-KB activity modulation

Transcription Sin3 and NuRD in transcription regulation

0.35

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for MTA3

Transcription Sin3 and NuRD in transcription regulation

1 GeneGo (Thomson Reuters) Pathway for MTA3

Transcription Sin3 and NuRD in transcription regulation

MTA3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MTA3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/579 Interacting proteins for MTA3 (Q9BTC8^{2, 3} ENSP00000385045⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 579)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC1	Q13547²^,³, ENSP00000362649⁴	MINT-6613980 MINT-6613746 MINT-7947479 MINT-6613885 I2D: score=1 STRING: ENSP00000362649
CHD3	Q12873²^,³, ENSP00000369716⁴	MINT-6613980 MINT-6613885 I2D: score=1 STRING: ENSP00000369716
HDAC2	Q92769²^,³, ENSP00000381331⁴	MINT-6613746 MINT-7947479 I2D: score=1 STRING: ENSP00000381331
ENSG00000206454	Q01860³	I2D: score=2
ENSG00000229094	Q01860³	I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IEA	--

MTA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MTA3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MTA3

1 Novoseek inferred chemical compound relationship for MTA3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	44.5	6	15358836 (3), 15169784 (2)

Search CenterWatch for drugs/clinical trials and news about MTA3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MTA3 gene (3 alternative transcripts):

NM_001282755.1 NM_001282756.1 NM_020744.3

Unigene Clusters for MTA3:

Metastasis associated 1 family, member 3

Hs.435413 [show with all ESTs], Hs.745162 [show with all ESTs]

Unigene Representative Sequences: AK127245, AL161954

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000405592(uc002rso.1) ENST00000406652(uc002rsp.1) ENST00000484780

ENST00000461256 ENST00000407270(uc002rsq.3) ENST00000454356 ENST00000406911(uc021vgm.1)

ENST00000409019 ENST00000430763 ENST00000405094 ENST00000433553 ENST00000493983

ENST00000491314 ENST00000490611 ENST00000472767 ENST00000475383 ENST00000482875

ENST00000467925

miRNA Products:
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate MTA3:
		hsa-miR-495
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for MTA3
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MTA3

Clone Products:		OriGene clones in human, mouse for MTA3 (see all 11) OriGene ORF clones in mouse, rat for MTA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MTA3 (NM_020744)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA3
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Additional mRNA sequence: AL161954.1

16 DOTS entries:

DT.95164032 DT.100891570 DT.92353481 DT.100891571 DT.100017990 DT.86846321 DT.75132968 DT.91784121

DT.121007802 DT.101967678 DT.91642530 DT.95164019 DT.95164023 DT.95164034 DT.95229053 DT.97826367

24/209 AceView cDNA sequences (see all 209):

AI342393 BE858185 BM707674 AI056219 CR597627 BQ953592 CR611589 AI422174

AW270719 CR619018 BX476217 BX367228 BC004227 AI076657 AF086450 AK027304

AL543402 CR612595 M79071 AI052453 AB033092 AI359618 CR598284 CA396914

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 (see all 10) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20a	·	20b	·	20c	·	20d	·
SP1:			-		-						-				-																				-		-		-										-		-
SP2:					-						-				-																				-		-		-
SP3:																																			-		-		-
SP4:																																			-				-
SP5:																																			-		-		-		-

ExUns:	20e	^	21	^	22a	·	22b	^	23
SP1:	-						-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MTA3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MTA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATACCACAGT

About this image

See MTA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTA3

SOURCE GeneReport for Unigene clusters: Hs.435413 Hs.745162

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8

Tissue specificity: No expression in nonepithelial cells

SABiosciences Custom PCR Arrays for MTA3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTA3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MTA3 gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mta3^{1 , 5}	metastasis associated 3^{1, 5}	86.36(n)¹ 95.06(a)¹		17 (54.53 cM)⁵ 116871¹ NM_001171052.1¹ NP_001164523.1¹ 83706163⁵
chicken (Gallus gallus)	Aves	MTA3¹	metastasis associated 1 family, member 3	83.47(n) 89.16(a)		421395 XM_419452.3 XP_419452.2
lizard (Anolis carolinensis)	Reptilia	MTA3⁶	metastasis associated 1 family, member 3	68(a)	1 ↔ 1	GL343231.1(167244-333673)
zebrafish (Danio rerio)	Actinopterygii	mta3¹	metastasis associated 1 family, member 3	70.29(n) 80.58(a)		100003254 NM_199912.1 NP_956206.1
fruit fly (Drosophila melanogaster)	Insecta	MTA1-like⁶	MTA1-like	34(a)	1 → many	3R(1464377-1474459)
worm (Caenorhabditis elegans)	Secernentea	lin-40¹	Protein LIN-40	51.98(n) 46.7(a)		178788 NM_071630.3 NP_504031.1

ENSEMBL Gene Tree for MTA3 (if available)
TreeFam Gene Tree for MTA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MTA3 gene

MTA1² MTA2² RERE² ATN1²

18/20 SIMAP similar genes for MTA3 using alignment to 7 protein entries: MTA3_HUMAN (see all proteins) (see all similar genes):

COX7A2 DRG2 IFT122 ZNF738 tmp_locus_6 IPO7

ZNF83 NSD1 KLHDC1 NUSAP1 PPIP5K2 ZNF568

DAPK2 MTA1 MTA2 TMEM67 DKFZp686F2281 NSRP1

MTA3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MTA3
PGOHUM00000240400

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186376634^1,2		--	42793684(+)	`CCCTTC/TAAGTC`	1	--	us2k¹		0	--	--	--	--
rs137900561^1,2		--	42793699(+)	`AGGCCC/TTTCAT`	1	--	us2k¹		0	--	--	--	--
rs112594626^1,2	C,F	--	42793717(+)	`TTCTGG/CATGAG`	1	--	us2k¹		2		CSA WA	120
rs113963561^1,2	C,F	--	42793757(+)	`TTTCTC/TGGCAT`	1	--	us2k¹		2		NA WA	120
rs78149247^1,2	F	--	42793983(+)	`AAACAC/TTGTGG`	1	--	us2k¹		1		EA	120
rs190823146^1,2		--	42794399(+)	`ACTCAA/CGTCCC`	1	--	us2k¹		0	--	--	--	--
rs143551881^1,2		--	42794400(+)	`CTCACA/GTCCCC`	1	--	us2k¹		0	--	--	--	--
rs72989185^1,2	C,F	--	42794533(+)	`CATCAC/TAAATG`	1	--	us2k¹		1		WA	2
rs187660747^1,2		--	42794685(+)	`CGTGTG/TTATTA`	1	--	us2k¹		0	--	--	--	--
rs147161731^1,2		--	42794696(+)	`TGCAGC/TAATGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MTA3 (42721709 - 42971709 bp, first 250kb of MTA3)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for MTA3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2719982	CNV	Deletion	23290073
esv2678416	CNV	Deletion	23128226
nsv524679	CNV	Loss	19592680
nsv873970	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MTA3 for disorders           About GeneDecksing

OMIM gene information: 609050    OMIM disorders: --

4 diseases for MTA3:    About MalaCards

b-cell lymphomas breast cancer ovarian cancer adenocarcinoma

5 Novoseek inferred disease relationships for MTA3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	40	8	15358836 (4), 16502042 (1), 16533771 (1)
cancer	21.9	5	18719363 (3), 19363681 (2)
carcinoma	21.8	3	19363681 (2), 16533771 (1)
tumors	20.5	3	16533771 (2), 14613024 (1)
metastasis	15.5	1	16533771 (1)

Genetic Association Database (GAD): MTA3
Human Genome Epidemiology (HuGE) Navigator: MTA3 (1 document)

Export disorders for MTA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MTA3 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with MTA3)

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MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PubMed id 12705869)^{1, 2, 3} Fujita N.... Wade P.A. (2003)
Emerging roles of MTA family members in human cancers. (PubMed id 14613024)^{1, 3, 9} Kumar R....Bagheri-Yarmand R. (2003)
Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PubMed id 16502042)^{1, 4, 9} Yu J.C....Shen C.Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. (PubMed id 15169784)^{1, 9} Mishra S.K....Kumar R. (2004)
Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. (PubMed id 15358836)^{1, 9} Fujita N....Wade P.A. (2004)
Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. (PubMed id 11483358)^{1, 9} Simpson A....Mahoney M.G. (2001)
The metastasis-associated genes MTA1 and MTA3 are abu ndantly expressed in human placenta and chorionic carcinoma cells. (PubMed id 19363681)^{1, 9} BrA1ning A....Mylonas I. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57504	HGNC: 23784	AceView: MTA3	Ensembl:ENSG00000057935	euGenes: HUgn57504
ECgene: MTA3	H-InvDB: MTA3

(According to HUGE)
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HUGE: KIAA1266

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MTA3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MTA3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MTA3 gene
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Patent Information for MTA3 gene:
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GeneCards and IP:
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Metastasis Associated 1 Family, Member 3

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