Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MTA3 Gene

protein-coding   GIFtS: 59
GCID: GC02P042722

Metastasis Associated 1 Family, Member 3

(Previous names: metastasis associated gene family, member 3)
  See MTA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Metastasis Associated 1 Family, Member 31 2
Metastasis Associated Gene Family, Member 31 2
Metastasis Associated Family, Member 32
Metastasis-Associated Protein MTA32
KIAA12663

External Ids:    HGNC: 237841   Entrez Gene: 575042   Ensembl: ENSG000000579357   OMIM: 6090505   UniProtKB: Q9BTC83   

Export aliases for MTA3 gene to outside databases

Previous GC identifers: GC02P042783 GC02P042963 GC02P042770 GC02P042696 GC02P042633 GC02P042577 GC02P042649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MTA3 Gene:
MTA3 (metastasis associated 1 family, member 3) is a protein-coding gene. Diseases associated with MTA3 include gastroesophageal junction adenocarcinoma. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8
Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1
transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.
Contributes to transcriptional repression by BCL6

Gene Wiki entry for MTA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTA3 gene promoter:
         ER-alpha   ISGF-3   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   STAT5A   POU3F2   Evi-1   FOXL1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MTA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p22.1

MTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTA3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P042722:  view genomic region     (about GC identifiers)

Start:
42,721,709 bp from pter      End:
42,984,087 bp from pter
Size:
262,379 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8 (See protein sequence)
Recommended Name: Metastasis-associated protein MTA3  
Size: 594 amino acids; 67504 Da
Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts
with BCL6
Sequence caution: Sequence=BAA86580.1; Type=Erroneous initiation;
Secondary accessions: Q9NSP2 Q9ULF4
Alternative splicing: 2 isoforms:  Q9BTC8-1   Q9BTC8-2   

Explore the universe of human proteins at neXtProt for MTA3: NX_Q9BTC8

Explore proteomics data for MTA3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys61
  • Modification sites at PhosphoSitePlus

  • See MTA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269684.1  NP_001269685.1  NP_065795.1  

    ENSEMBL proteins: 
     ENSP00000383973   ENSP00000384249   ENSP00000385045   ENSP00000391455   ENSP00000385241  
     ENSP00000386763   ENSP00000401815   ENSP00000385823   ENSP00000388722  
    Reactome Protein details: Q9BTC8

    MTA3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MTA3
    OriGene Protein Over-expression Lysate for MTA3
    OriGene MassSpec for MTA3
    OriGene Custom Protein Services for MTA3
    GenScript Custom Purified and Recombinant Proteins Services for MTA3
    Novus Biologicals MTA3 Proteins
    Novus Biologicals MTA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTA3

     
    Search eBioscience for Proteins for MTA3 

     
    antibodies-online proteins for MTA3 (6 products) 

     
    antibodies-online peptides for MTA3

    MTA3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MTA3
    Novus Biologicals MTA3 Antibodies
    Abcam antibodies for MTA3
    Cloud-Clone Corp. Antibodies for MTA3
    ThermoFisher Antibodies for MTA3
    LSBio Antibodies in human, mouse, rat for MTA3
    antibodies-online antibodies for MTA3 (31 products) 

    MTA3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MTA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTA3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTA3
    Cloud-Clone Corp. CLIAs for MTA3
    Search eBioscience for ELISAs for MTA3 
    antibodies-online kits for MTA3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GATAD: GATA zinc finger domain containing

    Selected InterPro protein domains (see all 6):
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001025 BAH_dom
     IPR000679 Znf_GATA
     IPR000949 ELM2_dom

    Graphical View of Domain Structure for InterPro Entry Q9BTC8

    ProtoNet protein and cluster: Q9BTC8

    3 Blocks protein domains:
    IPB000679 Zn-finger
    IPB000949 ELM2 domain
    IPB001025 Bromo adjacent region


    UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8
    Similarity: Contains 1 BAH domain
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 GATA-type zinc finger
    Similarity: Contains 1 SANT domain


    Find genes that share domains with MTA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTA3_HUMAN, Q9BTC8
    Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1
    transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.
    Contributes to transcriptional repression by BCL6
    Induction: By estrogen

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18451880
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with MTA3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mta3):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with MTA3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTA3:
    hsa-mir-296-3p (MIRT038438)

    Block miRNA regulation of human, mouse, rat MTA3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MTA3:
    hsa-miR-495
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTA3
    Predesigned siRNA for gene silencing in human, mouse, rat MTA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTA3

    Clone
    Products:
         
    OriGene clones in human, mouse for MTA3 (see all 10)
    OriGene ORF clones in mouse, rat for MTA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTA3 (NM_020744)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA3
    Addgene plasmids for MTA3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTA3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTA3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MTA3_HUMAN, Q9BTC8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008278cohesin complex IEA--
    GO:0016581NuRD complex IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with MTA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MTA3 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Promoter Clearance0.78
    2RNA Polymerase I Promoter Escape
    RNA Polymerase I Transcription Initiation0.55
    3Gene Expression
    Gene Expression0.40
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35


    Find genes that share SuperPaths with MTA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MTA3
        Transcription Sin3 and NuRD in transcription regulation

    1 Reactome Pathway for MTA3
        RNA Polymerase I Transcription Initiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MTA3
    Interactions:

        GeneGlobe Interaction Network for MTA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTA3 (Q9BTC81, 2, 3 ENSP000003850454) via UniProtKB, MINT, STRING, and/or I2D (see all 583)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1Q135472, 3, ENSP000003626494MINT-6613980 MINT-6613746 MINT-7947479 MINT-6613885 I2D: score=1 STRING: ENSP00000362649
    CHD3Q128732, 3, ENSP000003697164MINT-6613980 MINT-6613885 I2D: score=1 STRING: ENSP00000369716
    HDAC2Q927692, 3, ENSP000003813314MINT-6613746 MINT-7947479 I2D: score=1 STRING: ENSP00000381331
    ENSG00000206454Q018603, ENSP000003730164I2D: score=2 STRING: ENSP00000373016
    POU5F1Q018603, ENSP000002599154I2D: score=2 STRING: ENSP00000259915
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0010971positive regulation of G2/M transition of mitotic cell cycle IEA--

    Find genes that share ontologies with MTA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTA3

    1 Novoseek inferred chemical compound relationship for MTA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 44.5 6 15358836 (3), 15169784 (2)



    Find genes that share compounds with MTA3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MTA3 gene (3 alternative transcripts): 
    NM_001282755.1  NM_001282756.1  NM_020744.3  

    Unigene Cluster for MTA3:

    Metastasis associated 1 family, member 3
    Hs.435413  [show with all ESTs]
    Unigene Representative Sequence: AK127245
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000405592(uc002rso.1) ENST00000406652(uc002rsp.1) ENST00000484780
    ENST00000461256 ENST00000407270(uc002rsq.3) ENST00000454356 ENST00000406911(uc021vgm.1)
    ENST00000409019 ENST00000430763 ENST00000405094 ENST00000433553 ENST00000493983
    ENST00000491314 ENST00000490611 ENST00000472767 ENST00000475383 ENST00000482875
    ENST00000467925
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MTA3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MTA3:
    hsa-miR-495
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTA3
    Predesigned siRNA for gene silencing in human, mouse, rat MTA3
    Clone
    Products:
         
    OriGene clones in human, mouse for MTA3 (see all 10)
    OriGene ORF clones in mouse, rat for MTA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MTA3 (NM_020744)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA3
    Addgene plasmids for MTA3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MTA3
    OriGene qSTAR qPCR primer pairs in human, mouse for MTA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA3
      QuantiTect SYBR Green Assays in human, mouse, rat MTA3
      QuantiFast Probe-based Assays in human, mouse, rat MTA3

    Additional mRNA sequence: 

    AB033092.1 AF086450.1 AK027304.1 AK122690.1 AK126724.1 AK127245.1 BC004227.2 BC053631.1 

    16 DOTS entries:

    DT.95164032  DT.100891570  DT.92353481  DT.100891571  DT.100017990  DT.86846321  DT.75132968  DT.91784121 
    DT.101967678  DT.121007802  DT.91642530  DT.95164019  DT.95164023  DT.95164034  DT.95229053  DT.97826367 

    Selected AceView cDNA sequences (see all 209):

    AI342393 BE858185 BM707674 AI052453 AB033092 AI359618 CR598284 CA396914 
    AA102083 BF056179 BX107754 AA383427 BU733211 AA704967 AW007683 W80850 
    AI056219 CR597627 BQ953592 CR611589 AI422174 AW270719 CR619018 BX476217 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ·
    SP1:        -     -                 -           -                                                           -     -     -                             -     -   
    SP2:              -                 -           -                                                           -     -     -                                       
    SP3:                                                                                                        -     -     -                                       
    SP4:                                                                                                        -           -                                       
    SP5:                                                                                                        -     -     -     -                                 

    ExUns: 20e ^ 21 ^ 22a · 22b ^ 23
    SP1:  -                 -         
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MTA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MTA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACCACAGT
    MTA3 Expression
    About this image

    MTA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435413

    UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8
    Tissue specificity: Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells

        Custom PCR Arrays for MTA3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MTA3
    OriGene qSTAR qPCR primer pairs in human, mouse for MTA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA3
    QuantiTect SYBR Green Assays in human, mouse, rat MTA3
    QuantiFast Probe-based Assays in human, mouse, rat MTA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MTA3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mta31 , 5 metastasis associated 31, 5 86.36(n)1
    95.06(a)1
      17 (54.53 cM)5
    1168711  NM_001171052.11  NP_001164523.11 
     837061635 
    chicken
    (Gallus gallus)
    Aves MTA31 metastasis associated 1 family, member 3 83.78(n)
    88.5(a)
      421395  XM_004935353.1  XP_004935410.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTA36
    metastasis associated 1 family, member 3
    68(a)
    1 ↔ 1
    GL343231.1(167244-333673)
    zebrafish
    (Danio rerio)
    Actinopterygii mta31 metastasis associated 1 family, member 3 70.29(n)
    80.58(a)
      100003254  NM_199912.2  NP_956206.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-401 lin-40 52.58(n)
    47.89(a)
      178788  NM_182324.3  NP_872124.1 


    ENSEMBL Gene Tree for MTA3 (if available)
    TreeFam Gene Tree for MTA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MTA3 gene
    MTA12  MTA22  RERE2  ATN12  
    Selected SIMAP similar genes for MTA3 using alignment to 7 protein entries:     MTA3_HUMAN (see all proteins) (see all similar genes):
    COX7A2    DRG2    IFT122    ZNF738    tmp_locus_6    IPO7
    ZNF83    NSD1    KLHDC1    NUSAP1    PPIP5K2    ZNF568
    DAPK2    MTA1    MTA2    TMEM67    DKFZp686F2281    NSRP1

    Find genes that share paralogs with MTA3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MTA3
    PGOHUM00000240400


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MTA3 (see all 3021)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863766341,2
    --42793684(+) CCCTTC/TAAGTC 1 -- us2k10--------
    rs1379005611,2
    --42793699(+) AGGCCC/TTTCAT 1 -- us2k10--------
    rs1125946261,2
    C,F--42793717(+) TTCTGG/CATGAG 1 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs1139635611,2
    C,F--42793757(+) TTTCTC/TGGCAT 1 -- us2k12Minor allele frequency- T:0.03NA WA 120
    rs781492471,2
    F--42793983(+) AAACAC/TTGTGG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1908231461,2
    --42794399(+) ACTCAA/CGTCCC 1 -- us2k10--------
    rs1435518811,2
    --42794400(+) CTCACA/GTCCCC 1 -- us2k10--------
    rs729891851,2
    C,F--42794533(+) CATCAC/TAAATG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1876607471,2
    --42794685(+) CGTGTG/TTATTA 1 -- us2k10--------
    rs1471617311,2
    --42794696(+) TGCAGC/TAATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTA3 (42721709 - 42971709 bp, first 250kb of MTA3)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MTA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719982CNV Deletion23290073
    esv2678416CNV Deletion23128226
    nsv524679CNV Loss19592680
    nsv873970CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTA3
    DNA2.0 Custom Variant and Variant Library Synthesis for MTA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609050    OMIM disorders: --

    1 disease for MTA3:    
    About MalaCards
    gastroesophageal junction adenocarcinoma


    Find genes that share disorders with MTA3           About GenesLikeMe

    5 Novoseek inferred disease relationships for MTA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 40 8 15358836 (4), 16502042 (1), 16533771 (1)
    cancer 21.9 5 18719363 (3), 19363681 (2)
    carcinoma 21.8 3 19363681 (2), 16533771 (1)
    tumors 20.5 3 16533771 (2), 14613024 (1)
    metastasis 15.5 1 16533771 (1)

    Genetic Association Database (GAD): MTA3
    Human Genome Epidemiology (HuGE) Navigator: MTA3 (1 document)

    Export disorders for MTA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MTA3 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with MTA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PubMed id 12705869)1, 2, 3 Fujita N.... Wade P.A. (Cell 2003)
    2. Emerging roles of MTA family members in human cancers. (PubMed id 14613024)1, 3, 9 Kumar R....Bagheri-Yarmand R. (Semin. Oncol. 2003)
    3. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PubMed id 16502042)1, 4, 9 Yu J.C....Shen C.Y. (J. Biomed. Sci. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. (PubMed id 15454082)1, 2 Fujita N....Wade P.A. (Cell 2004)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    8. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. (PubMed id 15169784)1, 9 Mishra S.K....Kumar R. (J. Biol. Chem. 2004)
    9. Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. (PubMed id 15358836)1, 9 Fujita N....Wade P.A. (Mol. Endocrinol. 2004)
    10. Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. (PubMed id 11483358)1, 9 Simpson A....Mahoney M.G. (Gene 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57504 HGNC: 23784 AceView: MTA3 Ensembl:ENSG00000057935 euGenes: HUgn57504
    ECgene: MTA3 H-InvDB: MTA3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1266

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MTA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MTA3 gene:
    Search GeneIP for patents involving MTA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MTA3  
     OriGene qPCR primer pairs and template standards for MTA3   OriGene Protein Over-expression Lysate for MTA3  
     OriGene MassSpec for MTA3   OriGene clones in human, mouse for MTA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for MTA3   OriGene Purified Protein for MTA3  
     OriGene ORF clones in mouse, rat for MTA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MTA3   OriGene Custom Protein Services for MTA3  

     
     
     Block miRNA regulation of human, mouse, rat MTA3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MTA3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTA3 Predesigned siRNA for gene silencing in human, mouse, rat MTA3
     QuantiFast Probe-based Assays in human, mouse, rat MTA3 QuantiTect SYBR Green Assays in human, mouse, rat MTA3
     Custom PCR Arrays for MTA3 Search Chromatin IP Primers for MTA3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA3  GeneGlobe Interaction Network for MTA3
     Regulatory tfbs in MTA3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MTA3 GenScript cDNA clones with any tag delivered in your preferred vector for MTA3
     GenScript Custom Assay Services for MTA3 GenScript Custom overexpressing Cell Line Services for MTA3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MTA3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MTA3 antibodies
     MTA3 proteins
     MTA3 lysates
     Antibodies for MTA3
     See all of Abcam's Antibodies, Kits and Proteins for MTA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MTA3
     Antibodies for MTA3
     ELISAs for MTA3
     CLIAs for MTA3



     Browse ESI BIO Cell Lines and PureStem Progenitors for MTA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MTA3
     Browse SwitchGear Promoter luciferase reporter plasmids for MTA3
     ThermoFisher Antibodies for MTA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTA3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTA3
     LSBio Antibodies in human, mouse, rat for MTA3
     Browse compounds at ApexBio
     Addgene plasmids for MTA3
      Search eBioscience for proteins for MTA3
      Search eBioscience for elisas for MTA3
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for MTA3 (31 products)
     antibodies-online kits for MTA3 (6 products)
     antibodies-online peptides for MTA3
     antibodies-online proteins for MTA3 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MTA3 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4