MTA3 Gene

Aliases
for MTA3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02P042783 GC02P042963 GC02P042770 GC02P042696 GC02P042633 GC02P042577 GC02P042649

Summaries
for MTA3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MTA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_022184.16  NC_018913.2  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTA3

MTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P042722:  view genomic region     (about GC identifiers)

Proteins
for MTA3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MTA3: NX_Q9BTC8

Explore proteomics data for MTA3 at MOPED

Post-translational modifications: 

MTA3 Human Recombinant Protein Products:

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	antibodies-online peptides for MTA3

MTA3 Antibody Products:

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MTA3 Assay Products:

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Domains /
Families
for MTA3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9BTC8

Find genes that share domains with MTA3           About GenesLikeMe

Function
for MTA3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

(inferred from 1 allele) (MGI details for Mta3)

genOway: Develop your customized and physiologically relevant rodent model for MTA3

miRNA Products:		miRTarBase miRNAs that target MTA3: hsa-mir-296-3p (MIRT038438)
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		1 qRT-PCR Assays for microRNA that regulate MTA3:
		hsa-miR-495
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MTA3

Clone Products:		OriGene clones in human, mouse for MTA3 (see all 10) OriGene ORF clones in mouse, rat for MTA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Addgene plasmids for MTA3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MTA3
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

Localization
for MTA3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for MTA3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for MTA3 About     See pathways by source

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	SuperPath	Contained pathways About
1	RNA Polymerase I Promoter Opening	RNA Polymerase I Transcription 0.78 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.73 RNA Polymerase I Promoter Clearance 0.78
2	RNA Polymerase I Promoter Escape	RNA Polymerase I Transcription Initiation 0.55
3	Gene Expression	Gene Expression 0.40
4	Development NOTCH1-mediated pathway for NF-KB activity modulation	Transcription Sin3 and NuRD in transcription regulation 0.31

1 GeneGo (Thomson Reuters) Pathway for MTA3

Transcription Sin3 and NuRD in transcription regulation

1 Reactome Pathway for MTA3

RNA Polymerase I Transcription Initiation

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for MTA3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MTA3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MTA3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MTA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATACCACAGT

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for MTA3 OriGene qSTAR qPCR primer pairs in human, mouse for MTA3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA3
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		QuantiFast Probe-based Assays in human, mouse, rat MTA3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

Orthologs
for MTA3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MTA3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for MTA3 gene

MTA1²  MTA2²  RERE²  ATN1²  

Selected SIMAP similar genes for MTA3 using alignment to 7 protein entries:     MTA3_HUMAN (see all proteins) (see all similar genes):

COX7A2    DRG2    IFT122    ZNF738    tmp_locus_6    IPO7

ZNF83    NSD1    KLHDC1    NUSAP1    PPIP5K2    ZNF568

DAPK2    MTA1    MTA2    TMEM67    DKFZp686F2281    NSRP1

Find genes that share paralogs with MTA3           About GenesLikeMe


1 Pseudogenes.org Pseudogene for MTA3
PGOHUM00000240400

Genomic Variants
for MTA3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MTA3 (see all 3021)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1863766341,2		--	42793684(+)	CCCTTC/TAAGTC	1	--	us2k1		0	--	--	--	--
rs1379005611,2		--	42793699(+)	AGGCCC/TTTCAT	1	--	us2k1		0	--	--	--	--
rs1125946261,2	C,F	--	42793717(+)	TTCTGG/CATGAG	1	--	us2k1		2		CSA WA	120
rs1139635611,2	C,F	--	42793757(+)	TTTCTC/TGGCAT	1	--	us2k1		2		NA WA	120
rs781492471,2	F	--	42793983(+)	AAACAC/TTGTGG	1	--	us2k1		1		EA	120
rs1908231461,2		--	42794399(+)	ACTCAA/CGTCCC	1	--	us2k1		0	--	--	--	--
rs1435518811,2		--	42794400(+)	CTCACA/GTCCCC	1	--	us2k1		0	--	--	--	--
rs729891851,2	C,F	--	42794533(+)	CATCAC/TAAATG	1	--	us2k1		1		WA	2
rs1876607471,2		--	42794685(+)	CGTGTG/TTATTA	1	--	us2k1		0	--	--	--	--
rs1471617311,2		--	42794696(+)	TGCAGC/TAATGT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for MTA3 (42721709 - 42971709 bp, first 250kb of MTA3)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MTA3:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2719982	CNV	Deletion	23290073
esv2678416	CNV	Deletion	23128226
nsv524679	CNV	Loss	19592680
nsv873970	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MTA3

DNA2.0 Custom Variant and Variant Library Synthesis for MTA3

Disorders / Diseases
for MTA3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for MTA3

5 Novoseek inferred disease relationships for MTA3 gene    About this table

Publications
for MTA3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PubMed id 12705869)^{1, 2, 3} Fujita N.... Wade P.A. (Cell 2003)
2. Emerging roles of MTA family members in human cancers. (PubMed id 14613024)^{1, 3, 9} Kumar R....Bagheri-Yarmand R. (Semin. Oncol. 2003)
3. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PubMed id 16502042)^{1, 4, 9} Yu J.C....Shen C.Y. (J. Biomed. Sci. 2006)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. (PubMed id 15454082)^{1, 2} Fujita N....Wade P.A. (Cell 2004)
7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1999)
8. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. (PubMed id 15169784)^{1, 9} Mishra S.K....Kumar R. (J. Biol. Chem. 2004)
9. Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. (PubMed id 15358836)^{1, 9} Fujita N....Wade P.A. (Mol. Endocrinol. 2004)
10. Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. (PubMed id 11483358)^{1, 9} Simpson A....Mahoney M.G. (Gene 2001)

External Searches for MTA3 gene

Genome Databases showing MTA3 gene

Other Databases showing MTA3 gene

Specialized Databases showing MTA3 gene

Products
for MTA3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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