Aliases for MTA3 Gene
Aliases for MTA3 Gene
External Ids for MTA3 Gene
- HGNC: 23784
- Entrez Gene: 57504
- Ensembl: ENSG00000057935
- OMIM: 609050
- UniProtKB: Q9BTC8
Previous GeneCards Identifiers for MTA3 Gene
- GC02P042783
- GC02P042963
- GC02P042770
- GC02P042696
- GC02P042633
- GC02P042577
- GC02P042649
- GC02P042722
Summaries for MTA3 Gene
GeneCards Summary for MTA3 Gene
MTA3 (Metastasis Associated 1 Family Member 3) is a Protein Coding gene. Diseases associated with MTA3 include Gastroesophageal Junction Adenocarcinoma. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase I Promoter Escape. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MTA1.
UniProtKB/Swiss-Prot for MTA3 Gene
-
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA3 Gene
Genomics for MTA3 Gene
Regulatory Elements for MTA3 Gene
Enhancers for MTA3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02F042751 | 1.3 | Ensembl ENCODE | 23.6 | +259.6 | 259632 | 6.4 | HDGF MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 PAF1 SP5 MXD4 | MTA3 HAAO KCNG3 OXER1 RNU6-137P |
| GH02F043079 | 1.6 | FANTOM5 Ensembl ENCODE | 13.5 | +590.3 | 590255 | 10.0 | PKNOX1 ZFP64 SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF121 FOS SP5 | MTA3 GC02M043079 GC02M043092 RNU6-242P |
| GH02F042973 | 1.6 | FANTOM5 Ensembl ENCODE | 13.2 | +483.0 | 482955 | 8.2 | MLX ZFP64 ARID4B DMAP1 ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ZNF143 | MTA3 HAAO GC02M042943 GC02M043009 |
| GH02F041609 | 1.2 | Ensembl ENCODE | 13.5 | -883.9 | -883893 | 1.7 | HDAC1 ARID4B SIN3A ZBTB40 ZSCAN9 DNMT3B RARA ZNF766 ZNF143 CREM | MTA3 GC02P041527 LOC105374506 |
| GH02F041859 | 1.1 | Ensembl ENCODE | 13.5 | -634.2 | -634235 | 1.7 | CTCF TFAP4 JUN SIN3A CEBPG RAD21 ZKSCAN1 CTBP1 SMC3 FOS | MTA3 LINC01913 ENSG00000207218 GC02M041857 RNU4-63P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MTA3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MTA3 gene promoter:
Regulatory Element Products
Genomic Location for MTA3 Gene
- Chromosome:
- 2
- Start:
- 42,494,569 bp from pter
- End:
- 42,795,030 bp from pter
- Size:
- 300,462 bases
- Orientation:
- Plus strand
Genomic View for MTA3 Gene
Genes around MTA3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p21 by Ensembl
- 2p21 by Entrez Gene
- 2p21 by HGNC
MTA3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MTA3 Gene
Proteins for MTA3 Gene
-
Protein details for MTA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BTC8-MTA3_HUMAN
- Recommended name:
- Metastasis-associated protein MTA3
- Protein Accession:
- Q9BTC8
- Q9NSP2
- Q9ULF4
Protein attributes for MTA3 Gene
- Size:
- 594 amino acids
- Molecular mass:
- 67504 Da
- Quaternary structure:
-
- Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.
- SequenceCaution:
-
- Sequence=BAA86580.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MTA3 Gene
Post-translational modifications for MTA3 Gene
Other Protein References for MTA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MTA3
- Novus Biologicals Antibodies for MTA3
-
Abcam antibodies for MTA3
- Invitrogen Antibodies for MTA3
- antibodies-online Antibodies for MTA3: See all 52
- GeneTex MTA3 antibody for MTA3
-
St John's Laboratory Antibodies for MTA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for MTA3
Protein Products
-
OriGene Purified Proteins for MTA3
- Search Origene for MassSpec and Protein Over-expression Lysates for MTA3
- Origene Custom Protein Services for MTA3
- antibodies-online Proteins for MTA3: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MTA3
-
Abcam proteins for MTA3
Assay Products
No data available for DME Specific Peptides for MTA3 Gene
Domains & Families for MTA3 Gene
Gene Families for MTA3 Gene
Protein Domains for MTA3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MTA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BTC8- Domain:
-
- Contains 1 BAH domain.
- Contains 1 ELM2 domain.
- Contains 1 SANT domain.
- Similarity:
-
- Contains 1 GATA-type zinc finger.
Function for MTA3 Gene
Molecular function for MTA3 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
- UniProtKB/Swiss-Prot Induction:
- By estrogen.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0004407 | histone deacetylase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 22926524 |
| GO:0008270 | zinc ion binding | IEA | -- |
Phenotypes for MTA3 Gene
- MGI mutant phenotypes for MTA3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MTA3:
Animal Models for MTA3 Gene
- MGI Knock Outs for MTA3:
-
- Mta3 tm3a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTA3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MTA3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTA3 gene
- Search ViGene Biosciences for MTA3
CRISPR Products
-
OriGene CRISPR knockouts for MTA3
- GenScript: Design CRISPR guide RNA sequences for MTA3
miRNA for MTA3 Gene
- miRTarBase miRNAs that target MTA3
-
- hsa-mir-296-3p (MIRT038438)
- hsa-mir-495-3p (MIRT052935)
- hsa-mir-204-5p (MIRT513814)
- hsa-mir-211-5p (MIRT513815)
- hsa-mir-524-5p (MIRT513816)
- hsa-mir-520d-5p (MIRT513817)
- hsa-mir-4685-3p (MIRT513818)
- hsa-mir-4287 (MIRT513819)
- hsa-mir-6832-3p (MIRT513820)
- hsa-mir-153-5p (MIRT513821)
- hsa-mir-4687-5p (MIRT513822)
- hsa-mir-4422 (MIRT513823)
- hsa-mir-330-3p (MIRT513824)
- hsa-mir-4278 (MIRT535830)
- hsa-mir-6789-5p (MIRT535831)
- hsa-mir-6824-5p (MIRT535832)
- hsa-mir-4294 (MIRT535833)
- hsa-mir-6758-3p (MIRT535834)
- hsa-mir-4528 (MIRT535835)
- hsa-mir-6782-5p (MIRT535836)
- hsa-mir-6873-3p (MIRT539904)
- hsa-mir-7110-3p (MIRT539905)
- hsa-mir-6817-3p (MIRT539906)
- hsa-mir-4639-3p (MIRT539907)
- hsa-mir-603 (MIRT539908)
- hsa-mir-8485 (MIRT539909)
- hsa-mir-6845-3p (MIRT613629)
- hsa-mir-337-3p (MIRT616948)
- hsa-mir-4789-5p (MIRT623218)
- hsa-mir-1284 (MIRT623219)
- hsa-mir-570-3p (MIRT627995)
- hsa-mir-5001-3p (MIRT632700)
- hsa-mir-6722-5p (MIRT632701)
- hsa-mir-4772-3p (MIRT632702)
- hsa-mir-6787-3p (MIRT632703)
- hsa-mir-1304-3p (MIRT632704)
- hsa-mir-6736-3p (MIRT632705)
- hsa-mir-6890-3p (MIRT632706)
- hsa-mir-652-3p (MIRT632707)
- hsa-mir-216a-5p (MIRT632708)
- hsa-mir-6124 (MIRT637023)
- hsa-mir-3148 (MIRT637024)
- hsa-mir-875-3p (MIRT637025)
- hsa-mir-4446-5p (MIRT656079)
- hsa-mir-4755-5p (MIRT656080)
- hsa-mir-5006-3p (MIRT656081)
- hsa-mir-642a-5p (MIRT656082)
- hsa-mir-3156-3p (MIRT656083)
- hsa-mir-1260b (MIRT656084)
- hsa-mir-1260a (MIRT656085)
- hsa-mir-188-3p (MIRT656086)
- hsa-mir-1224-3p (MIRT656087)
- hsa-mir-141-5p (MIRT656088)
- hsa-mir-3152-5p (MIRT656089)
- hsa-mir-6809-3p (MIRT656090)
- hsa-mir-6836-3p (MIRT656091)
- hsa-mir-4753-3p (MIRT656092)
- hsa-mir-4465 (MIRT656093)
- hsa-mir-26b-5p (MIRT656094)
- hsa-mir-26a-5p (MIRT656095)
- hsa-mir-1297 (MIRT656096)
- hsa-mir-6829-3p (MIRT656097)
- hsa-mir-6791-3p (MIRT656098)
- hsa-mir-6778-3p (MIRT656099)
- hsa-mir-4726-3p (MIRT656100)
- hsa-mir-6764-5p (MIRT656101)
- hsa-mir-1915-3p (MIRT656102)
- hsa-mir-6840-3p (MIRT656103)
- hsa-mir-8062 (MIRT656104)
miRNA Products
- Search ViGene Biosciences for MTA3
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MTA3
- VectorBuilder custom plasmid, inducible vectors for MTA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MTA3
-
ViGene Biosciences adenoviral particle packaged cDNA for MTA3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MTA3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MTA3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTA3 Gene
Localization for MTA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MTA3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0008278 | cohesin complex | IEA | -- |
| GO:0016581 | NuRD complex | IEA | -- |
Pathways & Interactions for MTA3 Gene
Pathways by source for MTA3 Gene
1 GeneGo (Thomson Reuters) pathway for MTA3 Gene
Interacting Proteins for MTA3 Gene
Selected Interacting proteins:
Q9BTC8-MTA3_HUMAN
ENSP00000385045
for MTA3 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | IEA | -- |
| GO:0016575 | histone deacetylation | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP | 15454082 |
No data available for SIGNOR curated interactions for MTA3 Gene
Transcripts for MTA3 Gene
mRNA/cDNA for MTA3 Gene
- (11) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (209) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MTA3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MTA3
- GenScript: Design CRISPR guide RNA sequences for MTA3
miRNA Products
- Search ViGene Biosciences for MTA3
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MTA3
- VectorBuilder custom plasmid, inducible vectors for MTA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTA3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - |
| ExUns: | 20e | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: |
Expression for MTA3 Gene
This gene is overexpressed in Placenta (15.8), Lung (15.0), Peripheral blood mononuclear cells (8.7), and Testis (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of MTA3 Gene:
MTA3SOURCE GeneReport for Unigene cluster for MTA3 Gene:
Hs.435413mRNA Expression by UniProt/SwissProt for MTA3 Gene:
Q9BTC8-MTA3_HUMAN
Tissue specificity:
Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
Primer Products
-
OriGene qPCR primer pairs for MTA3
-
OriGene qPCR primer pairs and template standards for MTA3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTA3 Gene
Orthologs for MTA3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MTA3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | MTA3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | MTA3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MTA3 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mta3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mta3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MTA3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MTA3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MTA3 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | mta3 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | lin-40 34 |
|
- Species where no ortholog for MTA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for MTA3 Gene
(20) SIMAP similar genes for MTA3 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for MTA3 Gene
Variants for MTA3 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10153860 | -- | 42,495,376(+) | AAAAG(C/T)TCAAA | intron-variant, upstream-variant-2KB | |
| rs10165743 | -- | 42,534,490(+) | TATTC(A/G)GGAGG | intron-variant | |
| rs10165980 | -- | 42,740,631(+) | atctc(C/T)gtcag | intron-variant | |
| rs1016607 | -- | 42,744,547(-) | GAATG(A/G)GGGAA | intron-variant | |
| rs1016608 | -- | 42,744,324(-) | ATTAG(C/T)AAACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2671402 | CNV | deletion | 23128226 |
| esv2678416 | CNV | deletion | 23128226 |
| esv2719982 | CNV | deletion | 23290073 |
| esv3334685 | CNV | insertion | 20981092 |
| esv3555633 | CNV | deletion | 23714750 |
| esv3583763 | CNV | loss | 25503493 |
| esv3590505 | CNV | loss | 21293372 |
| esv3590507 | CNV | loss | 21293372 |
| esv3590508 | CNV | loss | 21293372 |
| nsv1110739 | CNV | insertion | 24896259 |
| nsv1127723 | CNV | deletion | 24896259 |
| nsv1129634 | CNV | tandem duplication | 24896259 |
| nsv1136297 | CNV | deletion | 24896259 |
| nsv1138770 | CNV | deletion | 24896259 |
| nsv1138771 | CNV | deletion | 24896259 |
| nsv1142272 | CNV | tandem duplication | 24896259 |
| nsv457152 | CNV | loss | 19166990 |
| nsv478760 | CNV | novel sequence insertion | 20440878 |
| nsv519877 | CNV | loss | 19592680 |
| nsv524679 | CNV | loss | 19592680 |
| nsv581644 | CNV | loss | 21841781 |
| nsv817795 | CNV | gain | 17921354 |
| nsv961770 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.42;
27.94% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MTA3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA3 Gene
Disorders for MTA3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastroesophageal junction adenocarcinoma |
|
|
Search MTA3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MTA3
No data available for UniProtKB/Swiss-Prot and Genatlas for MTA3 Gene
Publications for MTA3 Gene
- Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PMID: 16502042) Yu J.C. … Shen C.Y. (J. Biomed. Sci. 2006) 3 22 46 64
- MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PMID: 12705869) Fujita N. … Wade P.A. (Cell 2003) 2 3 4 64
- Emerging roles of MTA family members in human cancers. (PMID: 14613024) Kumar R. … Bagheri-Yarmand R. (Semin. Oncol. 2003) 2 3 22 64
- RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C. … Shang Y. (Oncogene 2013) 3 4 64
- The metastasis-associated genes MTA1 and MTA3 are abundantly expressed in human placenta and chorionic carcinoma cells. (PMID: 19363681) BrA1ning A. … Mylonas I. (Histochem. Cell Biol. 2009) 3 22 64
Products for MTA3 Gene
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for MTA3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MTA3
- Search Origene for MassSpec and Protein Over-expression Lysates for MTA3
- Origene Custom Protein Services for MTA3
- Origene shRNA, siRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for MTA3
- Browse OriGene Inhibitory RNA Products For MTA3
- OriGene qPCR primer pairs and template standards for MTA3
- OriGene qPCR primer pairs for MTA3
- OriGene CRISPR knockouts for MTA3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MTA3
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for MTA3
- GenScript Custom Assay Services for MTA3
- GenScript Custom overexpressing Cell Line Services for MTA3
- GenScript: Design CRISPR guide RNA sequences for MTA3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MTA3
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for MTA3
- Novus Biologicals proteins and lysates for MTA3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for MTA3
- Abcam proteins for MTA3
- Search for Assays for MTA3 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for MTA3
- antibodies-online Antibodies for MTA3: See all 52
- Search antibodies-online for kits
- antibodies-online Proteins for MTA3: See all 7
- Search antibodies-online for peptides
- GeneTex MTA3 antibody for MTA3
- Search GeneTex for Proteins for MTA3
- ViGene Biosciences adenoviral particle packaged cDNA for MTA3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for MTA3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for MTA3 gene
- Search ViGene Biosciences for MTA3
- Santa Cruz Biotechnology (SCBT) Antibodies for MTA3
- Search Santa Cruz Biotechnology (SCBT) for MTA3 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for MTA3 CRISPR
- Horizon Cell Lines for MTA3
- Cyagen custom Knockout/knockin (KOKI) mouse models for MTA3
- VectorBuilder custom plasmid, inducible vectors for MTA3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MTA3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MTA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab