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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MTA3 Gene

protein-coding   GIFtS: 56
GCID: GC02P042722

Metastasis Associated 1 Family, Member 3

(Previous names: metastasis associated gene family, member 3)
  See related diseases
at
MalaCards
 

Aliases
for MTA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Metastasis Associated 1 Family, Member 31 2
Metastasis Associated Gene Family, Member 31 2
Metastasis Associated Family, Member 32
Metastasis-Associated Protein MTA32
KIAA12663

External Ids:    HGNC: 237841   Entrez Gene: 575042   Ensembl: ENSG000000579357   OMIM: 6090505   UniProtKB: Q9BTC83   

Export aliases for MTA3 gene to outside databases

Previous GC identifers: GC02P042783 GC02P042963 GC02P042770 GC02P042696 GC02P042633 GC02P042577 GC02P042649


Summaries
for MTA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for MTA3 Gene: 
MTA3 (metastasis associated 1 family, member 3) is a protein-coding gene. Diseases associated with MTA3 include b-cell lymphomas, and breast cancer, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8
Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1
transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels

Gene Wiki entry for MTA3 Gene


Genomic Views
for MTA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTA3 gene promoter:
         ER-alpha   ISGF-3   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   STAT5A   POU3F2   Evi-1   FOXL1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MTA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p22.1

MTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTA3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P042722:  view genomic region     (about GC identifiers)

Start:
 42,721,709 bp from pter      End:
 42,984,087 bp from pter
Size:
 262,379 bases      Orientation:
 plus strand

Proteins
for MTA3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8 (See protein sequence)
Recommended Name: Metastasis-associated protein MTA3  
Size: 594 amino acids; 67504 Da
Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD)
Subcellular location: Nucleus
Sequence caution: Sequence=BAA86580.1; Type=Erroneous initiation;
Secondary accessions: Q9NSP2 Q9ULF4
Alternative splicing: 2 isoforms:  Q9BTC8-1   Q9BTC8-2   

Explore the universe of human proteins at neXtProt for MTA3: NX_Q9BTC8

Explore proteomics data for MTA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BTC8

    • MTA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MTA3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001269684.1  NP_001269685.1  NP_065795.1  

    ENSEMBL proteins: 
     ENSP00000383973   ENSP00000384249   ENSP00000385045   ENSP00000391455   ENSP00000385241  
     ENSP00000386763   ENSP00000401815   ENSP00000385823   ENSP00000388722  

    Human Recombinant Protein Products for MTA3: 
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    OriGene Purified Protein for MTA3
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    OriGene MassSpec for MTA3 
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    Novus Biologicals MTA3 Proteins
    Novus Biologicals MTA3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTA3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008278cohesin complex IEA--
    GO:0016581NuRD complex IEA--

    MTA3 for ontologies           About GeneDecksing



    MTA3 Antibody Products: 
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    Assay Products for MTA3: 
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    Cloud-Clone Corp. ELISAs for MTA3 
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    Protein Domains /
    Families
    for MTA3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    GATAD: GATA zinc finger domain containing

    5/6 InterPro protein domains (see all 6):
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001025 BAH_dom
     IPR000679 Znf_GATA
     IPR000949 ELM2_dom

    Graphical View of Domain Structure for InterPro Entry Q9BTC8

    ProtoNet protein and cluster: Q9BTC8

    3 Blocks protein domains:
    IPB000679 Zn-finger
    IPB000949 ELM2 domain
    IPB001025 Bromo adjacent region


    UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8
    Similarity: Contains 1 BAH domain
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 GATA-type zinc finger
    Similarity: Contains 1 SANT domain


    MTA3 for domains           About GeneDecksing


    Function
    for MTA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTA3_HUMAN, Q9BTC8
    Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1
    transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels
    Induction: By estrogen

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18451880
    GO:0008270zinc ion binding IEA--
         
    MTA3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mta3):
     behavior/neurological  homeostasis/metabolism  immune system 

    MTA3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MTA3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTA3 
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    hsa-miR-495
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    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of MTA3 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3


    Pathways & Interactions
    for MTA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MTA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    		Transcription Sin3 and NuRD in transcription regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MTA3
        Transcription Sin3 and NuRD in transcription regulation


    1 GeneGo (Thomson Reuters) Pathway for MTA3
        Transcription Sin3 and NuRD in transcription regulation



    MTA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/579 Interacting proteins for MTA3 (Q9BTC82, 3 ENSP000003850454) via UniProtKB, MINT, STRING, and/or I2D (see all 579)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1Q135472, 3, ENSP000003626494MINT-6613980 MINT-6613746 MINT-7947479 MINT-6613885 I2D: score=1 STRING: ENSP00000362649
    CHD3Q128732, 3, ENSP000003697164MINT-6613980 MINT-6613885 I2D: score=1 STRING: ENSP00000369716
    HDAC2Q927692, 3, ENSP000003813314MINT-6613746 MINT-7947479 I2D: score=1 STRING: ENSP00000381331
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0010971positive regulation of G2/M transition of mitotic cell cycle IEA--

    MTA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MTA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MTA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTA3

    1 Novoseek inferred chemical compound relationship for MTA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 44.5 6 15358836 (3), 15169784 (2)

    Search CenterWatch for drugs/clinical trials and news about MTA3

    Transcripts
    for MTA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MTA3 gene (3 alternative transcripts): 
    NM_001282755.1  NM_001282756.1  NM_020744.3  

    Unigene Clusters for MTA3:

    Metastasis associated 1 family, member 3
    Hs.435413  [show with all ESTs], Hs.745162  [show with all ESTs]
    Unigene Representative Sequences: AK127245, AL161954
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000405592(uc002rso.1) ENST00000406652(uc002rsp.1) ENST00000484780
    ENST00000461256 ENST00000407270(uc002rsq.3) ENST00000454356 ENST00000406911(uc021vgm.1)
    ENST00000409019 ENST00000430763 ENST00000405094 ENST00000433553 ENST00000493983
    ENST00000491314 ENST00000490611 ENST00000472767 ENST00000475383 ENST00000482875
    ENST00000467925
    miRNA
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTA3

    Additional mRNA sequence: AL161954.1 

    16 DOTS entries:

    DT.95164032  DT.100891570  DT.92353481  DT.100891571  DT.100017990  DT.86846321  DT.75132968  DT.91784121 
    DT.121007802  DT.101967678  DT.91642530  DT.95164019  DT.95164023  DT.95164034  DT.95229053  DT.97826367 

    24/209 AceView cDNA sequences (see all 209):

    AI342393 BE858185 BM707674 AI056219 CR597627 BQ953592 CR611589 AI422174 
    AW270719 CR619018 BX476217 BX367228 BC004227 AI076657 AF086450 AK027304 
    AL543402 CR612595 M79071 AI052453 AB033092 AI359618 CR598284 CA396914 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ·
    SP1:        -     -                 -           -                                                           -     -     -                             -     -   
    SP2:              -                 -           -                                                           -     -     -                                       
    SP3:                                                                                                        -     -     -                                       
    SP4:                                                                                                        -           -                                       
    SP5:                                                                                                        -     -     -     -                                 

    ExUns: 20e ^ 21 ^ 22a · 22b ^ 23
    SP1:  -                 -         
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for MTA3

    Expression
    for MTA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MTA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACCACAGT
    MTA3 Expression
    About this image


    See MTA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MTA3

    SOURCE GeneReport for Unigene clusters: Hs.435413 Hs.745162

    UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8
    Tissue specificity: No expression in nonepithelial cells

        SABiosciences Custom PCR Arrays for MTA3
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    In Situ
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    Orthologs
    for MTA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MTA3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mta31 , 5 metastasis associated 31, 5 86.36(n)1
    95.06(a)1    		   17 (54.53 cM)5
    1168711  NM_001171052.11  NP_001164523.11 
     837061635 
    chicken
    (Gallus gallus)    		 Aves MTA31 metastasis associated 1 family, member 3 83.47(n)
    89.16(a)    		   421395  XM_419452.3  XP_419452.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MTA36
    		 metastasis associated 1 family, member 3
    		 68(a)
    		 1 ↔ 1
    		 GL343231.1(167244-333673)
    zebrafish
    (Danio rerio)    		 Actinopterygii mta31 metastasis associated 1 family, member 3 70.29(n)
    80.58(a)    		   100003254  NM_199912.1  NP_956206.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MTA1-like6
    		 MTA1-like
    		 34(a)
    		 1 → many
    		 3R(1464377-1474459)
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-401 Protein LIN-40 51.98(n)
    46.7(a)    		   178788  NM_071630.3  NP_504031.1 


    ENSEMBL Gene Tree for MTA3 (if available)
    TreeFam Gene Tree for MTA3 (if available)

    Paralogs
    for MTA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MTA3 gene
    MTA12  MTA22  RERE2  ATN12  
    18/20 SIMAP similar genes for MTA3 using alignment to 7 protein entries:     MTA3_HUMAN (see all proteins) (see all similar genes):
    COX7A2    DRG2    IFT122    ZNF738    tmp_locus_6    IPO7
    ZNF83    NSD1    KLHDC1    NUSAP1    PPIP5K2    ZNF568
    DAPK2    MTA1    MTA2    TMEM67    DKFZp686F2281    NSRP1

    MTA3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MTA3
    PGOHUM00000240400


    Genomic Variants
    for MTA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3021 SNPs in MTA3 are shown (see all 3021)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1863766341,2
    		--42793684(+) CCCTTC/TAAGTC 1 -- us2k10--------
    rs1379005611,2
    		--42793699(+) AGGCCC/TTTCAT 1 -- us2k10--------
    rs1125946261,2
    		C,F--42793717(+) TTCTGG/CATGAG 1 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs1139635611,2
    		C,F--42793757(+) TTTCTC/TGGCAT 1 -- us2k12Minor allele frequency- T:0.03NA WA 120
    rs781492471,2
    		F--42793983(+) AAACAC/TTGTGG 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1908231461,2
    		--42794399(+) ACTCAA/CGTCCC 1 -- us2k10--------
    rs1435518811,2
    		--42794400(+) CTCACA/GTCCCC 1 -- us2k10--------
    rs729891851,2
    		C,F--42794533(+) CATCAC/TAAATG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1876607471,2
    		--42794685(+) CGTGTG/TTATTA 1 -- us2k10--------
    rs1471617311,2
    		--42794696(+) TGCAGC/TAATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MTA3 (42721709 - 42971709 bp, first 250kb of MTA3)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MTA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719982CNV Deletion23290073
    esv2678416CNV Deletion23128226
    nsv524679CNV Loss19592680
    nsv873970CNV Gain21882294

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    Disorders / Diseases
    for MTA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 609050    OMIM disorders: --

    4 diseases for MTA3:    About MalaCards
    b-cell lymphomas    breast cancer    ovarian cancer    adenocarcinoma


    MTA3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for MTA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 40 8 15358836 (4), 16502042 (1), 16533771 (1)
    cancer 21.9 5 18719363 (3), 19363681 (2)
    carcinoma 21.8 3 19363681 (2), 16533771 (1)
    tumors 20.5 3 16533771 (2), 14613024 (1)
    metastasis 15.5 1 16533771 (1)

    Genetic Association Database (GAD): MTA3
    Human Genome Epidemiology (HuGE) Navigator: MTA3 (1 document)

    Export disorders for MTA3 gene to outside databases

    Publications
    for MTA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MTA3 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with MTA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PubMed id 12705869)1, 2, 3 Fujita N.... Wade P.A. (2003)
    2. Emerging roles of MTA family members in human cancers. (PubMed id 14613024)1, 3, 9 Kumar R....Bagheri-Yarmand R. (2003)
    3. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PubMed id 16502042)1, 4, 9 Yu J.C....Shen C.Y. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    7. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. (PubMed id 15169784)1, 9 Mishra S.K....Kumar R. (2004)
    8. Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. (PubMed id 15358836)1, 9 Fujita N....Wade P.A. (2004)
    9. Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. (PubMed id 11483358)1, 9 Simpson A....Mahoney M.G. (2001)
    10. The metastasis-associated genes MTA1 and MTA3 are abu ndantly expressed in human placenta and chorionic carcinoma cells. (PubMed id 19363681)1, 9 BrA1ning A....Mylonas I. (2009)

    External Searches for MTA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MTA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57504 HGNC: 23784 AceView: MTA3 Ensembl:ENSG00000057935 euGenes: HUgn57504
    ECgene: MTA3 H-InvDB: MTA3

    Other Databases showing MTA3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1266

    Specialized Databases showing MTA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MTA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTA3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MTA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MTA3 gene:
    Search GeneIP for patents involving MTA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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