Aliases for MTA3 Gene
External Ids for MTA3 Gene
Previous GeneCards Identifiers for MTA3 Gene
GeneCards Summary for MTA3 Gene
MTA3 (Metastasis Associated 1 Family Member 3) is a Protein Coding gene. Diseases associated with MTA3 include Gastroesophageal Junction Adenocarcinoma. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MTA1.
UniProtKB/Swiss-Prot for MTA3 Gene
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.