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Set Analyses:

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MTA3 Gene

protein-coding GIFtS: 59
GCID: GC02P042722

Metastasis Associated 1 Family, Member 3

(Previous names: metastasis associated gene family, member 3)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Metastasis Associated 1 Family, Member 3¹ ²
Metastasis Associated Gene Family, Member 3¹ ²
Metastasis Associated Family, Member 3²
Metastasis-Associated Protein MTA3²
KIAA1266³

External Ids:	HGNC: 23784¹	Entrez Gene: 57504²	Ensembl: ENSG00000057935⁷	OMIM: 609050⁵	UniProtKB: Q9BTC8³

Export aliases for MTA3 gene to outside databases

Previous GC identifers: GC02P042783 GC02P042963 GC02P042770 GC02P042696 GC02P042633 GC02P042577 GC02P042649

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MTA3 Gene:

MTA3 (metastasis associated 1 family, member 3) is a protein-coding gene. Diseases associated with MTA3 include cancer progression/metastasis, and attention deficit hyperactivity disorder. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8

Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1

transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.

Contributes to transcriptional repression by BCL6

Gene Wiki entry for MTA3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NT_022184.16 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the MTA3 gene promoter:
ER-alpha ISGF-3 AML1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) STAT5A POU3F2 Evi-1 FOXL1 Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for MTA3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p22.1

MTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTA3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P042722: view genomic region (about GC identifiers)

Start:	42,721,709 bp from pter	End:	42,984,087 bp from pter
Size:	262,379 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8 (See protein sequence)

Recommended Name: Metastasis-associated protein MTA3

Size: 594 amino acids; 67504 Da

Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts

with BCL6

Sequence caution: Sequence=BAA86580.1; Type=Erroneous initiation;

Secondary accessions: Q9NSP2 Q9ULF4

Alternative splicing: 2 isoforms: Q9BTC8-1 Q9BTC8-2

Explore the universe of human proteins at neXtProt for MTA3: NX_Q9BTC8

Explore proteomics data for MTA3 at MOPED

Post-translational modifications:

Ubiquitination² at Lys61

Modification sites at PhosphoSitePlus

See MTA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001269684.1 NP_001269685.1 NP_065795.1

ENSEMBL proteins:

ENSP00000383973 ENSP00000384249 ENSP00000385045 ENSP00000391455 ENSP00000385241

ENSP00000386763 ENSP00000401815 ENSP00000385823 ENSP00000388722

Reactome Protein details: Q9BTC8

MTA3 Human Recombinant Protein Products:

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	OriGene Purified Protein for MTA3 OriGene Protein Over-expression Lysate for MTA3 OriGene MassSpec for MTA3 OriGene Custom Protein Services for MTA3
	GenScript Custom Purified and Recombinant Proteins Services for MTA3
	Novus Biologicals MTA3 Proteins Novus Biologicals MTA3 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for MTA3

MTA3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse OriGene Antibodies OriGene Custom Antibody Services for MTA3
	Novus Biologicals MTA3 Antibodies
	Abcam antibodies for MTA3
	Cloud-Clone Corp. Antibodies for MTA3
	ThermoFisher Antibodies for MTA3
	LSBio Antibodies in human, mouse, rat for MTA3

MTA3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for MTA3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MTA3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MTA3 Cloud-Clone Corp. CLIAs for MTA3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

GATAD: GATA zinc finger domain containing

Selected InterPro protein domains (see all 6):

IPR017884 SANT_dom

IPR001005 SANT/Myb

IPR001025 BAH_dom

IPR000679 Znf_GATA

IPR000949 ELM2_dom

Graphical View of Domain Structure for InterPro Entry Q9BTC8

ProtoNet protein and cluster: Q9BTC8

3 Blocks protein domains:

IPB000679 Zn-finger

IPB000949 ELM2 domain

IPB001025 Bromo adjacent region

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8

Similarity: Contains 1 BAH domain

Similarity: Contains 1 ELM2 domain

Similarity: Contains 1 GATA-type zinc finger

Similarity: Contains 1 SANT domain

MTA3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MTA3_HUMAN, Q9BTC8

Function: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1

transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.

Contributes to transcriptional repression by BCL6

Induction: By estrogen

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	18451880
GO:0008270	zinc ion binding	IEA	--

MTA3 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mta3):

behavior/neurological

hematopoietic system

homeostasis/metabolism

immune system

MTA3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTA3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTA3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTA3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTA3

miRNA Products:		miRTarBase miRNAs that target MTA3: hsa-mir-296-3p (MIRT038438)

		Block miRNA regulation of human, mouse, rat MTA3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate MTA3:
		hsa-miR-495
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MTA3
		Predesigned siRNA for gene silencing in human, mouse, rat MTA3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MTA3

Clone Products:		OriGene clones in human, mouse for MTA3 (see all 10) OriGene ORF clones in mouse, rat for MTA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MTA3 (NM_020744)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MTA3
		Browse ESI BIO Cell Lines and PureStem Progenitors for MTA3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MTA3_HUMAN, Q9BTC8: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0008278	cohesin complex	IEA	--
GO:0016581	NuRD complex	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

MTA3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MTA3 About

See pathways by source

SuperPath

Contained pathways About

RNA Polymerase I Promoter Opening

	RNA Polymerase I Transcription	0.78			RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.73
	RNA Polymerase I Promoter Clearance	0.78

RNA Polymerase I Promoter Escape

RNA Polymerase I Transcription Initiation

0.55

Gene Expression

Gene Expression

0.40

Development NOTCH1 mediated pathway for NF KB activity modulation

Transcription Sin3 and NuRD in transcription regulation

0.35

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for MTA3

Transcription Sin3 and NuRD in transcription regulation

1 Reactome Pathway for MTA3

RNA Polymerase I Transcription Initiation

MTA3 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MTA3
Interactions:

GeneGlobe Interaction Network for MTA3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MTA3 (Q9BTC8^{1, 2, 3} ENSP00000385045⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 583)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC1	Q13547²^,³, ENSP00000362649⁴	MINT-6613980 MINT-6613746 MINT-7947479 MINT-6613885 I2D: score=1 STRING: ENSP00000362649
CHD3	Q12873²^,³, ENSP00000369716⁴	MINT-6613980 MINT-6613885 I2D: score=1 STRING: ENSP00000369716
HDAC2	Q92769²^,³, ENSP00000381331⁴	MINT-6613746 MINT-7947479 I2D: score=1 STRING: ENSP00000381331
ENSG00000206454	Q01860³, ENSP00000373016⁴	I2D: score=2 STRING: ENSP00000373016
POU5F1	Q01860³, ENSP00000259915⁴	I2D: score=2 STRING: ENSP00000259915

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IEA	--

MTA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MTA3

1 Novoseek inferred chemical compound relationship for MTA3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	44.5	6	15358836 (3), 15169784 (2)

MTA3 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MTA3 gene (3 alternative transcripts):

NM_001282755.1 NM_001282756.1 NM_020744.3

Unigene Cluster for MTA3:

Metastasis associated 1 family, member 3

Hs.435413 [show with all ESTs]

Unigene Representative Sequence: AK127245

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000405592(uc002rso.1) ENST00000406652(uc002rsp.1) ENST00000484780

ENST00000461256 ENST00000407270(uc002rsq.3) ENST00000454356 ENST00000406911(uc021vgm.1)

ENST00000409019 ENST00000430763 ENST00000405094 ENST00000433553 ENST00000493983

ENST00000491314 ENST00000490611 ENST00000472767 ENST00000475383 ENST00000482875

ENST00000467925

miRNA Products:		Block miRNA regulation of human, mouse, rat MTA3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate MTA3:
		hsa-miR-495
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MTA3
		Predesigned siRNA for gene silencing in human, mouse, rat MTA3

Clone Products:		OriGene clones in human, mouse for MTA3 (see all 10) OriGene ORF clones in mouse, rat for MTA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MTA3 (NM_020744)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA3

Primer Products:		OriGene qPCR primer pairs and template standards for MTA3 OriGene qSTAR qPCR primer pairs in human, mouse for MTA3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MTA3
		QuantiTect SYBR Green Assays in human, mouse, rat MTA3
		QuantiFast Probe-based Assays in human, mouse, rat MTA3

Additional mRNA sequence:

AB033092.1 AF086450.1 AK027304.1 AK122690.1 AK126724.1 AK127245.1 BC004227.2 BC053631.1

16 DOTS entries:

DT.95164032 DT.100891570 DT.92353481 DT.100891571 DT.100017990 DT.86846321 DT.75132968 DT.91784121

DT.101967678 DT.121007802 DT.91642530 DT.95164019 DT.95164023 DT.95164034 DT.95229053 DT.97826367

Selected AceView cDNA sequences (see all 209):

AI342393 BE858185 BM707674 AI052453 AB033092 AI359618 CR598284 CA396914

AA102083 BF056179 BX107754 AA383427 BU733211 AA704967 AW007683 W80850

AI056219 CR597627 BQ953592 CR611589 AI422174 AW270719 CR619018 BX476217

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTA3 (see all 10) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20a	·	20b	·	20c	·	20d	·
SP1:			-		-						-				-																				-		-		-										-		-
SP2:					-						-				-																				-		-		-
SP3:																																			-		-		-
SP4:																																			-				-
SP5:																																			-		-		-		-

ExUns:	20e	^	21	^	22a	·	22b	^	23
SP1:	-						-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MTA3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MTA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATACCACAGT

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MTA3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MTA3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.435413

UniProtKB/Swiss-Prot: MTA3_HUMAN, Q9BTC8

Tissue specificity: Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells

Custom PCR Arrays for MTA3

Primer Products:		OriGene qPCR primer pairs and template standards for MTA3 OriGene qSTAR qPCR primer pairs in human, mouse for MTA3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MTA3
		QuantiTect SYBR Green Assays in human, mouse, rat MTA3
		QuantiFast Probe-based Assays in human, mouse, rat MTA3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MTA3 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mta3^{1 , 5}	metastasis associated 3^{1, 5}	86.36(n)¹ 95.06(a)¹		17 (54.53 cM)⁵ 116871¹ NM_001171052.1¹ NP_001164523.1¹ 83706163⁵
chicken (Gallus gallus)	Aves	MTA3¹	metastasis associated 1 family, member 3	83.78(n) 88.5(a)		421395 XM_004935353.1 XP_004935410.1
lizard (Anolis carolinensis)	Reptilia	MTA3⁶	metastasis associated 1 family, member 3	68(a)	1 ↔ 1	GL343231.1(167244-333673)
zebrafish (Danio rerio)	Actinopterygii	mta3¹	metastasis associated 1 family, member 3	70.29(n) 80.58(a)		100003254 NM_199912.2 NP_956206.1
worm (Caenorhabditis elegans)	Secernentea	lin-40¹	lin-40	52.58(n) 47.89(a)		178788 NM_182324.3 NP_872124.1

ENSEMBL Gene Tree for MTA3 (if available)
TreeFam Gene Tree for MTA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MTA3 gene

MTA1² MTA2² RERE² ATN1²

Selected SIMAP similar genes for MTA3 using alignment to 7 protein entries: MTA3_HUMAN (see all proteins) (see all similar genes):

COX7A2 DRG2 IFT122 ZNF738 tmp_locus_6 IPO7

ZNF83 NSD1 KLHDC1 NUSAP1 PPIP5K2 ZNF568

DAPK2 MTA1 MTA2 TMEM67 DKFZp686F2281 NSRP1

MTA3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MTA3
PGOHUM00000240400

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186376634^1,2		--	42793684(+)	`CCCTTC/TAAGTC`	1	--	us2k¹		0	--	--	--	--
rs137900561^1,2		--	42793699(+)	`AGGCCC/TTTCAT`	1	--	us2k¹		0	--	--	--	--
rs112594626^1,2	C,F	--	42793717(+)	`TTCTGG/CATGAG`	1	--	us2k¹		2		CSA WA	120
rs113963561^1,2	C,F	--	42793757(+)	`TTTCTC/TGGCAT`	1	--	us2k¹		2		NA WA	120
rs78149247^1,2	F	--	42793983(+)	`AAACAC/TTGTGG`	1	--	us2k¹		1		EA	120
rs190823146^1,2		--	42794399(+)	`ACTCAA/CGTCCC`	1	--	us2k¹		0	--	--	--	--
rs143551881^1,2		--	42794400(+)	`CTCACA/GTCCCC`	1	--	us2k¹		0	--	--	--	--
rs72989185^1,2	C,F	--	42794533(+)	`CATCAC/TAAATG`	1	--	us2k¹		1		WA	2
rs187660747^1,2		--	42794685(+)	`CGTGTG/TTATTA`	1	--	us2k¹		0	--	--	--	--
rs147161731^1,2		--	42794696(+)	`TGCAGC/TAATGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MTA3 (42721709 - 42971709 bp, first 250kb of MTA3)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for MTA3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2719982	CNV	Deletion	23290073
esv2678416	CNV	Deletion	23128226
nsv524679	CNV	Loss	19592680
nsv873970	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609050 OMIM disorders: --

8 diseases for MTA3:
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cancer progression/metastasis attention deficit hyperactivity disorder brain cancer b-cell lymphomas

breast cancer ovarian cancer adenocarcinoma hiv-1

MTA3 for disorders About GeneDecksing

5 Novoseek inferred disease relationships for MTA3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	40	8	15358836 (4), 16502042 (1), 16533771 (1)
cancer	21.9	5	18719363 (3), 19363681 (2)
carcinoma	21.8	3	19363681 (2), 16533771 (1)
tumors	20.5	3	16533771 (2), 14613024 (1)
metastasis	15.5	1	16533771 (1)

Genetic Association Database (GAD): MTA3
Human Genome Epidemiology (HuGE) Navigator: MTA3 (1 document)

Export disorders for MTA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MTA3 gene, integrated from 10 sources (see all 48):
(articles sorted by number of sources associating them with MTA3)

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MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. (PubMed id 12705869)^{1, 2, 3} Fujita N.... Wade P.A. (Cell 2003)
Emerging roles of MTA family members in human cancers. (PubMed id 14613024)^{1, 3, 9} Kumar R....Bagheri-Yarmand R. (Semin. Oncol. 2003)
Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PubMed id 16502042)^{1, 4, 9} Yu J.C....Shen C.Y. (J. Biomed. Sci. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. (PubMed id 15454082)^{1, 2} Fujita N....Wade P.A. (Cell 2004)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1999)
Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. (PubMed id 15169784)^{1, 9} Mishra S.K....Kumar R. (J. Biol. Chem. 2004)
Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. (PubMed id 15358836)^{1, 9} Fujita N....Wade P.A. (Mol. Endocrinol. 2004)
Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. (PubMed id 11483358)^{1, 9} Simpson A....Mahoney M.G. (Gene 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57504	HGNC: 23784	AceView: MTA3	Ensembl:ENSG00000057935	euGenes: HUgn57504
ECgene: MTA3	H-InvDB: MTA3

(According to HUGE)
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HUGE: KIAA1266

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MTA3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MTA3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MTA3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MTA3 gene:
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Metastasis Associated 1 Family, Member 3

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Metastasis Associated 1 Family, Member 3

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