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MTA2 Gene

protein-coding   GIFtS: 62
GCID: GC11M062360

Metastasis Associated 1 Family, Member 2

(Previous names: metastasis associated gene family, member 2)
(Previous symbol: MTA1L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metastasis Associated 1 Family, Member 21 2     MTA1-L1 Protein2 3
MTA1L11 2 3 5     P53 Target Protein In Deacetylase Complex2 3
Metastasis Associated Gene Family, Member 21 2     Metastasis -Associated Gene 1-Like 12
Metastasis-Associated 1-Like 12 3     Metastasis-Associated Protein 22
PID2 3     Metastasis-Associated Protein MTA22

External Ids:    HGNC: 74111   Entrez Gene: 92192   Ensembl: ENSG000001494807   OMIM: 6039475   UniProtKB: O947763   

Export aliases for MTA2 gene to outside databases

Previous GC identifers: GC11M062136 GC11M062119 GC11M058689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTA2 Gene:
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase
complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly
expressed in many tissues. It may represent one member of a small gene family that encode different but related
proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on
transcriptional regulation may include chromatin remodeling. It is closely related to another member of this
family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two
proteins are so closely related that they share the same types of domains. These domains include two DNA binding
domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins
known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of
growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
(provided by RefSeq, May 2011)

GeneCards Summary for MTA2 Gene:
MTA2 (metastasis associated 1 family, member 2) is a protein-coding gene. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTA3.

UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776
Function: May be involved in the regulation of gene expression as repressor and activator. The repression might be
related to covalent modification of histone proteins

Gene Wiki entry for MTA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTA2 gene promoter:
         CREB   Sp1   p53   deltaCREB   CUTL1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTA2 promoter sequence
   Search Chromatin IP Primers for MTA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13.1   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12-q13.1

MTA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTA2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062360:  view genomic region     (about GC identifiers)

Start:
62,360,675 bp from pter      End:
62,369,312 bp from pter
Size:
8,638 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776 (See protein sequence)
Recommended Name: Metastasis-associated protein MTA2  
Size: 668 amino acids; 75023 Da
Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts
with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with FAM64A
Sequence caution: Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q9UQB5

Explore the universe of human proteins at neXtProt for MTA2: NX_O94776

Explore proteomics data for MTA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys152, Lys508, Lys522, Lys611
  • Modification sites at PhosphoSitePlus

  • See MTA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004730.2  
    ENSEMBL proteins: 
     ENSP00000278823   ENSP00000431346   ENSP00000431797  
    Reactome Protein details: O94776

    MTA2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MTA2

     
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    antibodies-online proteins for MTA2 (5 products) 

     
    antibodies-online peptides for MTA2

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    antibodies-online antibodies for MTA2 (67 products) 

    MTA2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GATAD: GATA zinc finger domain containing

    Selected InterPro protein domains (see all 6):
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001025 BAH_dom
     IPR000679 Znf_GATA
     IPR000949 ELM2_dom

    Graphical View of Domain Structure for InterPro Entry O94776

    ProtoNet protein and cluster: O94776

    3 Blocks protein domains:
    IPB000679 Zn-finger
    IPB000949 ELM2 domain
    IPB001025 Bromo adjacent region


    UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776
    Similarity: Contains 1 BAH domain
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 GATA-type zinc finger
    Similarity: Contains 1 SANT domain


    Find genes that share domains with MTA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTA2_HUMAN, O94776
    Function: May be involved in the regulation of gene expression as repressor and activator. The repression might be
    related to covalent modification of histone proteins

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000989transcription factor binding transcription factor activity IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI15920471
    GO:0001103RNA polymerase II repressing transcription factor binding IPI--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
         
    Find genes that share ontologies with MTA2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MTA2:
     Decreased Salmonella enterica   Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mta2):
     cellular  craniofacial  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
     reproductive system  skeleton 

    Find genes that share phenotypes with MTA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mta2tm1.1Yzha for MTA2

       genOway: Develop your customized and physiologically relevant rodent model for MTA2

    miRNA
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    miRTarBase miRNAs that target MTA2:
    hsa-mir-125b-2-3p (MIRT038634), hsa-mir-423-3p (MIRT042480), hsa-mir-505-3p (MIRT041029), hsa-mir-34a-5p (MIRT025233), hsa-mir-146a-5p (MIRT004731), hsa-mir-222-3p (MIRT046730), hsa-mir-548a-3p (MIRT040512), hsa-mir-186-5p (MIRT044965), hsa-mir-559 (MIRT004116), hsa-mir-365a-3p (MIRT044044), hsa-mir-661 (MIRT004117), hsa-mir-335-5p (MIRT017668), hsa-mir-615-3p (MIRT040292)

    Block miRNA regulation of human, mouse, rat MTA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTA2 (see all 26):
    hsa-miR-21* hsa-miR-3194-5p hsa-miR-1321 hsa-miR-4251 hsa-miR-148b hsa-miR-449a hsa-miR-650 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMTA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MTA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MTA2 (NM_004739)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTA2_HUMAN, O94776: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex TAS10444591
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IDA15920471
    GO:0005730NOT nucleolus IDA--
    GO:0016581NuRD complex IDA19644445

    Find genes that share ontologies with MTA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTA2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Promoter Clearance0.78
    2RNA Polymerase I Promoter Escape
    RNA Polymerase I Transcription Initiation0.55
    3Gene Expression
    Gene Expression0.40
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    5Transcription P53 signaling pathway
    Transcription P53 signaling pathway


    Find genes that share SuperPaths with MTA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for MTA2
        Transcription P53 signaling pathway
    Transcription Sin3 and NuRD in transcription regulation

    2 BioSystems Pathways for MTA2
        EGFR1 Signaling Pathway
    Signaling events mediated by HDAC Class I

    1 Reactome Pathway for MTA2
        RNA Polymerase I Transcription Initiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTA2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTA2 (O947761, 2, 3 ENSP000002788234) via UniProtKB, MINT, STRING, and/or I2D (see all 898)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1Q135472, 3, ENSP000003626494MINT-6613980 MINT-7947479 MINT-6613885 MINT-7943970 MINT-8048833 MINT-7945693 MINT-8048844 MINT-7944011 MINT-6613697 MINT-7943765 MINT-8309424 I2D: score=4 STRING: ENSP00000362649
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006306DNA methylation IEA--
    GO:0006333chromatin assembly or disassembly TAS10444591
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0016575histone deacetylation ----

    Find genes that share ontologies with MTA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTA2

    1 Novoseek inferred chemical compound relationship for MTA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 40.8 2 18174918 (1)



    Find genes that share compounds with MTA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MTA2 gene: 
    NM_004739.3  

    Unigene Cluster for MTA2:

    Metastasis associated 1 family, member 2
    Hs.173043  [show with all ESTs]
    Unigene Representative Sequence: NM_004739
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278823(uc010rlx.1 uc001ntq.2) ENST00000524902 ENST00000527204
    ENST00000531179 ENST00000531261 ENST00000526844 ENST00000532239
    miRNA
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    Block miRNA regulation of human, mouse, rat MTA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTA2 (see all 26):
    hsa-miR-21* hsa-miR-3194-5p hsa-miR-1321 hsa-miR-4251 hsa-miR-148b hsa-miR-449a hsa-miR-650 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidMTA2 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MTA2 (NM_004739)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA2
    Primer
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    OriGene qPCR primer pairs and template standards for MTA2
    OriGene qSTAR qPCR primer pairs in human, mouse for MTA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA2
      QuantiTect SYBR Green Assays in human, mouse, rat MTA2
      QuantiFast Probe-based Assays in human, mouse, rat MTA2

    Additional mRNA sequence: 

    AB016591.1 AF295807.1 AK301569.1 BC023656.2 BC053650.1 CR749481.1 

    12 DOTS entries:

    DT.40120984  DT.100816505  DT.100023584  DT.97861405  DT.120740843  DT.91748966  DT.100699305  DT.99975877 
    DT.120740817  DT.91748286  DT.91981747  DT.99930197 

    19 AceView cDNA sequences:

    AL580744 CK819574 BM563145 BM129842 BG765494 BG765875 BM748993 BE148666 
    BM129583 BQ354007 BF921441 BF933478 BX473072 BI761567 AW605885 BF990046 
    BF897932 BM129316 AA861111 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTA2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:              -           -                             -                                                                                                   
    SP4:              -           -                                                                                                                                 
    SP5:                          -                                                                                                                                 

    ExUns: 20a · 20b ^ 21
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MTA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MTA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAACCTA
    MTA2 Expression
    About this image


    MTA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MTA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.173043

    UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTA2: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MTA2
    OriGene qSTAR qPCR primer pairs in human, mouse for MTA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA2
    QuantiTect SYBR Green Assays in human, mouse, rat MTA2
    QuantiFast Probe-based Assays in human, mouse, rat MTA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTA2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mta21 , 5 metastasis-associated gene family, member 21, 5 91.17(n)1
    98.5(a)1
      19 (6.04 cM)5
    239421  NM_011842.31  NP_035972.31 
     89418755 
    lizard
    (Anolis carolinensis)
    Reptilia MTA26
    metastasis associated 1 family, member 2
    81(a)
    1 ↔ 1
    GL343739.1(271348-291613)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5452 Xenopus laevis metastasis associated 1-like protein more 76.76(n)    AF170344.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi29g022 Danio rerio cDNA clone MGC63487 IMAGE2602610, complete more 77.92(n)    BC055273.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MTA1-like6
    MTA1-like
    38(a)
    1 ↔ 1
    3R(1464377-1474459)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-406
    Protein LIN-40, isoform d
    23(a)
    1 ↔ 1
    V(3704995-3712858) WBGene00003025


    ENSEMBL Gene Tree for MTA2 (if available)
    TreeFam Gene Tree for MTA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTA2 gene
    MTA32  MTA12  RERE2  ATN12  
    4 SIMAP similar genes for MTA2 using alignment to 1 protein entry:     MTA2_HUMAN:
    DKFZp686F2281    tmp_locus_6    MTA3    MTA1

    Find genes that share paralogs with MTA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTA2 (see all 234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798254241,2
    C,F--62361266(+) CCCTTC/TGACAC 1 -- ut311Minor allele frequency- T:0.03NA 120
    rs1928250351,2
    --62361292(+) TTTGGG/TTGCCC 1 -- ut310--------
    rs2008252881,2
    C--62361432(+) TCAGCA/GTTGGC 2 T M mis10--------
    rs1388924871,2
    C,F--62361808(+) GCTGGC/TTGTGA 2 Q syn11Minor allele frequency- T:0.00NA 4552
    rs1420637501,2
    C--62361816(+) TGAGCT/CTGAAC 2 /S /G mis11Minor allele frequency- C:0.00NA 4552
    rs2011846671,2
    --62361953(+) CACCCA/GACTCA 1 -- int10--------
    rs1509438401,2
    C,F--62362051(+) TTTCTG/ATTGAT 2 /N syn12Minor allele frequency- A:0.00NA EU 5707
    rs1998625411,2
    --62362057(+) TTGATC/TGGTGT 2 P syn10--------
    rs11361401,2
    C--62362098(-) CCCAGG/ACACCC 2 /T /A mis12Minor allele frequency- A:0.00NA 4
    rs1997871171,2
    --62362110(+) ACTGG-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MTA2 (62360675 - 62369312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MTA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897622CNV Loss21882294
    nsv832180CNV Loss17160897
    nsv825939CNV Gain20364138
    nsv832182CNV Gain+Loss17160897
    nsv514630CNV Complex21397061

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MTA2
    DNA2.0 Custom Variant and Variant Library Synthesis for MTA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603947    OMIM disorders: --


    Find genes that share disorders with MTA2           About GenesLikeMe

    3 Novoseek inferred disease relationships for MTA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 32.7 3 12920132 (1), 19702911 (1), 16533771 (1)
    breast cancer 30.8 1 16533771 (1)
    tumors 24.1 5 12920132 (1), 19702911 (1), 19116762 (1), 16533771 (1)


    Export disorders for MTA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTA2 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with MTA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, mapping and characterization of a novel human gene, MTA1-L1. showing homology to a metastasis-associated gene, MTA1. (PubMed id 9929979)1, 2, 3, 9 Futamura M....Tokino T. (J. Hum. Genet. 1999)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (PubMed id 11331609)1, 2 Shi Y.... Evans R.M. (Genes Dev. 2001)
    5. Deacetylation of p53 modulates its effect on cell growth and apoptosis. (PubMed id 11099047)1, 2 Luo J.... Gu W. (Nature 2000)
    6. Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. (PubMed id 19702911)1, 9 Lee H....Kim K.W. (J. Gastroenterol. Hepatol. 2009)
    7. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. (PubMed id 12920132)1, 9 Yao Y.-L. and Yang W.-M. (J. Biol. Chem. 2003)
    8. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. (PubMed id 18413351)1, 9 Lee C....Agoston D.V. (Cereb. Cortex 2008)
    9. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. (PubMed id 12124384)1, 9 Saito M. and Ishikawa F. (J. Biol. Chem. 2002)
    10. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PubMed id 10545197)1, 9 Schmidt D.R. and Schreiber S.L. (Biochemistry 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9219 HGNC: 7411 AceView: MTA2.1 Ensembl:ENSG00000149480 euGenes: HUgn9219
    ECgene: MTA2 H-InvDB: MTA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTA2 gene:
    Search GeneIP for patents involving MTA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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