MTA2 Gene
protein-coding GIFtS: 61
GCID: GC11M062360
|
|
metastasis associated 1 family, member 2(Previous names: metastasis associated gene family, member 2 )
(Previous symbol: MTA1L1)
| |
Aliases
for MTA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Metastasis Associated 1 Family, Member 21 2 | | P53 Target Protein In Deacetylase Complex2 3 | | MTA1L11 2 3 5 | | MTA1-L11 | | Metastasis Associated Gene Family, Member 21 2 | | Metastasis -Associated Gene 1-Like 12 | | Metastasis-Associated 1-Like 12 3 | | Metastasis-Associated Protein 22 | | PID2 3 | | Metastasis-Associated Protein MTA22 | | MTA1-L1 Protein2 3 | | |
Export aliases for MTA2 gene to outside databasesPrevious GC identifers: GC11M062136 GC11M062119 GC11M058689 |
Summaries
for MTA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MTA2:
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylasecomplex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressedin many tissues. It may represent one member of a small gene family that encode different but related proteinsinvolved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptionalregulation may include chromatin remodeling. It is closely related to another member of this family, a protein thathas been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely relatedthat they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and adomain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this geneproduct is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting aconnection between these gene family members and metastasis. (provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776Function: May be involved in the regulation of gene expression as repressor and activator. The repression might berelated to covalent modification of histone proteins
Gene Wiki entry for MTA2
|
Genomic Views
for MTA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTA2 gene promoter:
CREB Sp1 p53 deltaCREB CUTL1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12-q13.1 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12-q13.1MTA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M062360: view genomic region
(about GC identifiers)
Start:
|
62,360,675 bp from pter |
End:
|
62,369,312 bp from pter |
Size:
|
8,638 bases |
Orientation:
|
minus strand |
|
Proteins
for MTA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776 (See
protein sequence)Recommended Name: Metastasis-associated protein MTA2 Size: 668 amino acids; 75023 Da
Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts withHDAC7, p53/TP53, MINT and MBD3 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q9UQB5Explore the universe of human proteins at neXtProt for MTA2: NX_O94776
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94776
MTA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004730.2
ENSEMBL proteins: ENSP00000278823 ENSP00000431346 ENSP00000431797
Human Recombinant Protein Products for MTA2:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
MTA2 for ontologies About GeneDecksing
MTA2 Antibody Products:
Assay Products for MTA2: |
Protein
Domains /
Families
for MTA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTA2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O94776ProtoNet protein and cluster: O94776 3 Blocks protein families: IPB000679 Zn-finger IPB000949 ELM2 domain IPB001025 Bromo adjacent region
UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776Similarity: Contains 1 BAH domainSimilarity: Contains 1 ELM2 domainSimilarity: Contains 1 GATA-type zinc fingerSimilarity: Contains 1 SANT domain |
Function
for MTA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MTA2_HUMAN, O94776Function: May be involved in the regulation of gene expression as repressor and activator. The repression might berelated to covalent modification of histone proteins Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000989 | transcription factor binding transcription factor activity |
IEA | -- | | GO:0001085 | RNA polymerase II transcription factor binding |
IPI | 15920471 | | GO:0001103 | RNA polymerase II repressing transcription factor binding |
IPI | -- | | GO:0003682 | chromatin binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
MTA2 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for MTA2:
12 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mta2):
MTA2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Mta2tm1.1Yzha for MTA2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MTA2 (NM_004739) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA2 |
|
Pathways & Interactions
for MTA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Sin3 and NuRD in transcription regulation | | | 2 | Transcription_P53 signaling pathway | | | 3 | EGFR1 Signaling Pathway | | | 4 | Signaling events mediated by HDAC Class I | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for MTA2
2  GeneGo (Thomson Reuters) Pathways for MTA2
2  BioSystems Pathways for MTA2
MTA2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/840 Interacting proteins for MTA2 (O947761, 2, 3 ENSP000002788234) via UniProtKB, MINT, STRING, and/or I2D (see all 840)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006306 | DNA methylation |
IEA | -- | | GO:0006333 | chromatin assembly or disassembly |
TAS | 10444591 | | GO:0016575 | histone deacetylation |
-- | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
-- | -- |
MTA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MTA2 for compounds About GeneDecksing
 Browse Tocris compounds for MTA2
1 Novoseek chemical compound relationship for MTA2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| estrogen |
40.8 |
2 |
18174918 (1) |
Search CenterWatch for drugs/clinical trials and news about MTA2
|
Transcripts
for MTA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTA2 gene: NM_004739.3 Unigene Cluster for MTA2: Metastasis associated 1 family, member 2 Hs.173043 [show with all ESTs]Unigene Representative Sequence: NM_0047397 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000278823(uc010rlx.1 uc001ntq.2) ENST00000524902 ENST00000527204
ENST00000531179 ENST00000531261 ENST00000526844 ENST00000532239
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MTA2 (NM_004739) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA2 |
Additional cDNA sequence: AB016591.1 AF295807.1 AK301569.1 BC023656.2 BC053650.1 CR749481.1 12 DOTS entries: DT.40120984 DT.100816505 DT.100023584 DT.97861405 DT.120740843 DT.91748966 DT.100699305 DT.99975877 DT.120740817 DT.91748286 DT.91981747 DT.99930197 19 AceView cDNA sequences: BG765494 BG765875 CK819574 BM563145 AL580744 BM129842 BE148666 BM748993 BM129583 BF933478 BX473072 BQ354007 BF921441 BF897932 BF990046 BI761567 AW605885 BM129316 AA861111
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MTA2 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20a | · | 20b | ^ | 21 |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for MTA2
|
Expression
for MTA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGAACCTA
About this image
See MTA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTA2
SOURCE GeneReport for Unigene cluster: Hs.173043
UniProtKB/Swiss-Prot: MTA2_HUMAN, O94776Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including MTA2: | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA2 |
Orthologs
for MTA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MTA2 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
MTA26 |
-- |
93(a) |
1 ↔ 1 |
GL343739.1(272520-294304) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.5452 |
Xenopus laevis metastasis associated 1-like protein more |
76.76(n) |
|
AF170344.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi29g022 |
Danio rerio cDNA clone MGC63487 IMAGE2602610, complete more |
77.92(n) |
|
BC055273.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
MTA1-like6 |
MTA1-like |
36(a) |
1 → many |
3R(1464377-1474459) |
worm
(Caenorhabditis elegans) |
Secernentea |
lin-406 |
abnormal cell LINeage family member (lin-40) |
21(a) |
1 → many |
V(3704982-3712845) |
ENSEMBL Gene Tree for MTA2 (if available)
TreeFam Gene Tree for MTA2 (if available) |
Paralogs
for MTA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTA2 gene
- MTA32 RERE2 MTA12 ATN12
4 SIMAP similar genes for MTA2 using alignment to 1 protein entry: MTA2_HUMAN:DKFZp686F2281 tmp_locus_6 MTA3 MTA1
MTA2 for paralogs About GeneDecksing
|
Genomic Variants
for MTA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTA2 (62360675 - 62369312 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MTA2
1 CNV: 4749 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTA2 |
|
Disorders
/ Diseases
for MTA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTA2 for disorders About GeneDecksing
OMIM gene information: 603947
OMIM disorders: --
14  diseases for MTA2: About MalaCardsdna topoisomerase ii lewy body dementia supranuclear palsy progressive supranuclear palsy
carcinoma cancer progression/metastasis frontotemporal dementia pick's disease
dementia dermatomyositis breast cancer hepatocellular carcinoma
lung cancer neuronitis
5 diseases from the University of Copenhagen DISEASES database for MTA2:Pick's disease Progressive supranuclear palsy Frontotemporal dementia Lewy body dementia
Alzheimer's disease 3 Novoseek disease relationships for MTA2 gene About this table
Export disorders for MTA2 gene to outside databases
|
Publications
for MTA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTA2 gene, integrated from 9 sources (see all 94):
(articles sorted by number of sources associating them with MTA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, mapping and characterization of a novel human gene, MTA1-L1. showing homology to a metastasis-associated gene, MTA1. (PubMed id 9929979)1, 2, 3, 9 Futamura M....Tokino T. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. (PubMed id 11331609)1, 2 Shi Y....Evans R.M. (2001)
- Deacetylation of p53 modulates its effect on cell growth and apoptosis. (PubMed id 11099047)1, 2 Luo J.... Gu W. (2000)
- Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. (PubMed id 19702911)1, 9 Lee H....Kim K.W. (2009)
- The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. (PubMed id 12920132)1, 9 Yao Y.-L. and Yang W.-M. (2003)
- Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. (PubMed id 18413351)1, 9 Lee C....Agoston D.V. (2008)
- The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. (PubMed id 12124384)1, 9 Saito M. and Ishikawa F. (2002)
- Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PubMed id 10545197)1, 9 Schmidt D.R. and Schreiber S.L. (1999)
|
External Searches for MTA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MTA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MTA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MTA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MTA2 gene:
Search GeneIP for patents involving MTA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MTA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for MTA2 | | OriGene shRNA RFP for MTA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTA2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MTA2 | | OriGene 3'-UTR Clone for MTA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTA2 | | OriGene Custom Protein Services for MTA2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTA2 |
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| | | | Search Tocris compounds for MTA2 |
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 | | | MTA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA2 |
|  |  |  |  | | | | ThermoFisher Antibodies for MTA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA2 |
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