Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTA2 Gene

Aliases for MTA2 Gene

  • Metastasis Associated 1 Family, Member 2 2 3
  • MTA1L1 3 4 6
  • Metastasis Associated Gene Family, Member 2 2 3
  • P53 Target Protein In Deacetylase Complex 3 4
  • Metastasis-Associated 1-Like 1 3 4
  • MTA1-L1 Protein 3 4
  • PID 3 4
  • Metastasis -Associated Gene 1-Like 1 3
  • Metastasis-Associated Protein MTA2 3
  • Metastasis-Associated Protein 2 3

External Ids for MTA2 Gene

Previous HGNC Symbols for MTA2 Gene

  • MTA1L1

Previous GeneCards Identifiers for MTA2 Gene

  • GC11M062136
  • GC11M062119
  • GC11M062360
  • GC11M058689

Summaries for MTA2 Gene

Entrez Gene Summary for MTA2 Gene

  • This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

GeneCards Summary for MTA2 Gene

MTA2 (Metastasis Associated 1 Family, Member 2) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is RERE.

UniProtKB/Swiss-Prot for MTA2 Gene

  • May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins

Gene Wiki entry for MTA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA2 Gene

Genomics for MTA2 Gene

Regulatory Elements for MTA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTA2 Gene

Start:
62,593,203 bp from pter
End:
62,601,840 bp from pter
Size:
8,638 bases
Orientation:
Minus strand

Genomic View for MTA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA2 Gene

Proteins for MTA2 Gene

  • Protein details for MTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94776-MTA2_HUMAN
    Recommended name:
    Metastasis-associated protein MTA2
    Protein Accession:
    O94776
    Secondary Accessions:
    • Q68DB1
    • Q9UQB5

    Protein attributes for MTA2 Gene

    Size:
    668 amino acids
    Molecular mass:
    75023 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with FAM64A. Interacts with NACC2.
    SequenceCaution:
    • Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA2 Gene

Proteomics data for MTA2 Gene at MOPED

Post-translational modifications for MTA2 Gene

  • Ubiquitination at Lys32, Lys152, Lys508, Lys522, and Lys611
  • Modification sites at PhosphoSitePlus

Other Protein References for MTA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MTA2 Gene

Domains for MTA2 Gene

Gene Families for MTA2 Gene

HGNC:
  • GATAD :GATA zinc finger domain containing

Suggested Antigen Peptide Sequences for MTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94776

UniProtKB/Swiss-Prot:

MTA2_HUMAN :
  • O94776
Domain:
  • Contains 1 BAH domain.
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with MTA2: view

Function for MTA2 Gene

Molecular function for MTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins

Gene Ontology (GO) - Molecular Function for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0000989 transcription factor binding transcription factor activity IEA --
GO:0001085 RNA polymerase II transcription factor binding IPI 15920471
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
genes like me logo Genes that share ontologies with MTA2: view
genes like me logo Genes that share phenotypes with MTA2: view

Animal Models for MTA2 Gene

MGI Knock Outs for MTA2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTA2 Gene

Localization for MTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTA2 Gene COMPARTMENTS Subcellular localization image for MTA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 10444591
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 15920471
genes like me logo Genes that share ontologies with MTA2: view

Pathways for MTA2 Gene

genes like me logo Genes that share pathways with MTA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006306 DNA methylation IEA --
GO:0006325 chromatin organization TAS --
GO:0006333 chromatin assembly or disassembly TAS 10444591
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with MTA2: view

Compounds for MTA2 Gene

(1) Novoseek inferred chemical compound relationships for MTA2 Gene

Compound -log(P) Hits PubMed IDs
estrogen 40.8 1
genes like me logo Genes that share compounds with MTA2: view

Transcripts for MTA2 Gene

mRNA/cDNA for MTA2 Gene

Unigene Clusters for MTA2 Gene

Metastasis associated 1 family, member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MTA2 Gene

GeneLoc Exon Structure for
MTA2
ECgene alternative splicing isoforms for
MTA2

Expression for MTA2 Gene

mRNA expression in normal human tissues for MTA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MTA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Breast (8.6), and Lymph node (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTA2 Gene

SOURCE GeneReport for Unigene cluster for MTA2 Gene Hs.173043

mRNA Expression by UniProt/SwissProt for MTA2 Gene

O94776-MTA2_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with MTA2: view

Expression partners for MTA2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MTA2 Gene

Orthologs for MTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTA2 35
  • 93.04 (n)
  • 98.65 (a)
MTA2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTA2 35
  • 93.11 (n)
  • 98.95 (a)
MTA2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mta2 35
  • 91.17 (n)
  • 98.5 (a)
Mta2 16
Mta2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mta2 35
  • 90.52 (n)
  • 98.05 (a)
oppossum
(Monodelphis domestica)
Mammalia MTA2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTA2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTA2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mta2 35
  • 75.45 (n)
  • 90.36 (a)
Str.6927 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.545 35
zebrafish
(Danio rerio)
Actinopterygii mta2 35
  • 71.96 (n)
  • 81.51 (a)
wufi29g02 35
mta2 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MTA1-like 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-40 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for MTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTA2 Gene

ENSEMBL:
Gene Tree for MTA2 (if available)
TreeFam:
Gene Tree for MTA2 (if available)

Paralogs for MTA2 Gene

Paralogs for MTA2 Gene

Selected SIMAP similar genes for MTA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTA2: view

Variants for MTA2 Gene

Sequence variations from dbSNP and Humsavar for MTA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1064468 -- 62,598,607(-) CAGGG(A/G)TGTCT missense, reference
rs1136140 -- 62,594,626(-) CCCAG(A/G)CACCC missense, reference
rs2427644 -- 62,601,701(-) GAGCT(C/T)GTTCC utr-variant-5-prime
rs2516634 -- 62,599,714(-) TTGCG(C/T)TTTTT intron-variant
rs2849030 -- 62,599,514(-) TTTTC(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTA2 Gene

Variant ID Type Subtype PubMed ID
nsv832180 CNV Loss 17160897
nsv832182 CNV Gain+Loss 17160897
nsv825939 CNV Gain 20364138
nsv514630 CNV Complex 21397061
nsv897622 CNV Loss 21882294

Relevant External Links for MTA2 Gene

HapMap Linkage Disequilibrium report
MTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA2 Gene

Disorders for MTA2 Gene

(3) Novoseek inferred disease relationships for MTA2 Gene

Disease -log(P) Hits PubMed IDs
metastasis 32.7 3
breast cancer 30.8 1
tumors 24.1 4
genes like me logo Genes that share disorders with MTA2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for MTA2 Gene

Publications for MTA2 Gene

  1. Molecular cloning, mapping and characterization of a novel human gene, MTA1-L1. showing homology to a metastasis-associated gene, MTA1. (PMID: 9929979) Futamura M. … Tokino T. (J. Hum. Genet. 1999) 2 3 4 23
  2. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PMID: 10545197) Schmidt D.R. … Schreiber S.L. (Biochemistry 1999) 3 23
  3. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. (PMID: 12124384) Saito M. … Ishikawa F. (J. Biol. Chem. 2002) 3 23
  4. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. (PMID: 12920132) Yao Y.-L. … Yang W.-M. (J. Biol. Chem. 2003) 3 23
  5. Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. (PMID: 19702911) Lee H. … Kim K.W. (J. Gastroenterol. Hepatol. 2009) 3 23

Products for MTA2 Gene

Sources for MTA2 Gene

Back to Top

Content