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Aliases for MTA2 Gene

Aliases for MTA2 Gene

  • Metastasis Associated 1 Family Member 2 2 3 5
  • Metastasis Associated Gene Family, Member 2 2 3
  • P53 Target Protein In Deacetylase Complex 3 4
  • Metastasis-Associated 1-Like 1 3 4
  • MTA1-L1 Protein 3 4
  • MTA1L1 3 4
  • PID 3 4
  • Metastasis -Associated Gene 1-Like 1 3
  • Metastasis-Associated Protein MTA2 3
  • Metastasis-Associated Protein 2 3

External Ids for MTA2 Gene

Previous HGNC Symbols for MTA2 Gene

  • MTA1L1

Previous GeneCards Identifiers for MTA2 Gene

  • GC11M062136
  • GC11M062119
  • GC11M062360
  • GC11M058689

Summaries for MTA2 Gene

Entrez Gene Summary for MTA2 Gene

  • This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

GeneCards Summary for MTA2 Gene

MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Among its related pathways are Transcription_P53 signaling pathway and Chromatin organization. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is MTA1.

UniProtKB/Swiss-Prot for MTA2 Gene

  • May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Gene Wiki entry for MTA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA2 Gene

Genomics for MTA2 Gene

Regulatory Elements for MTA2 Gene

Enhancers for MTA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MTA2 on UCSC Golden Path with GeneCards custom track

Promoters for MTA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MTA2 Gene

Chromosome:
11
Start:
62,593,203 bp from pter
End:
62,601,840 bp from pter
Size:
8,638 bases
Orientation:
Minus strand

Genomic View for MTA2 Gene

Genes around MTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA2 Gene

Proteins for MTA2 Gene

  • Protein details for MTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94776-MTA2_HUMAN
    Recommended name:
    Metastasis-associated protein MTA2
    Protein Accession:
    O94776
    Secondary Accessions:
    • Q68DB1
    • Q9UQB5

    Protein attributes for MTA2 Gene

    Size:
    668 amino acids
    Molecular mass:
    75023 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with FAM64A. Interacts with NACC2.
    SequenceCaution:
    • Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for MTA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA2 Gene

Post-translational modifications for MTA2 Gene

  • Ubiquitination at Lys 152, Lys 508, Lys 522, and Lys 611
  • Modification sites at PhosphoSitePlus

Other Protein References for MTA2 Gene

No data available for DME Specific Peptides for MTA2 Gene

Domains & Families for MTA2 Gene

Suggested Antigen Peptide Sequences for MTA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94776

UniProtKB/Swiss-Prot:

MTA2_HUMAN :
  • Contains 1 BAH domain.
  • Contains 1 GATA-type zinc finger.
Domain:
  • Contains 1 BAH domain.
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with MTA2: view

Function for MTA2 Gene

Molecular function for MTA2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Gene Ontology (GO) - Molecular Function for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0000989 transcription factor activity, transcription factor binding IEA --
GO:0001085 RNA polymerase II transcription factor binding IPI 15920471
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
genes like me logo Genes that share ontologies with MTA2: view
genes like me logo Genes that share phenotypes with MTA2: view

Animal Models for MTA2 Gene

MGI Knock Outs for MTA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MTA2 Gene

Localization for MTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTA2 Gene COMPARTMENTS Subcellular localization image for MTA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 10444591
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 15920471
genes like me logo Genes that share ontologies with MTA2: view

Pathways & Interactions for MTA2 Gene

genes like me logo Genes that share pathways with MTA2: view

Gene Ontology (GO) - Biological Process for MTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006306 DNA methylation IEA --
GO:0006333 chromatin assembly or disassembly TAS 10444591
GO:0010762 regulation of fibroblast migration IEA --
GO:0016575 histone deacetylation IEA --
genes like me logo Genes that share ontologies with MTA2: view

No data available for SIGNOR curated interactions for MTA2 Gene

Drugs & Compounds for MTA2 Gene

(1) Drugs for MTA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MTA2: view

Transcripts for MTA2 Gene

Unigene Clusters for MTA2 Gene

Metastasis associated 1 family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1:
SP2:
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MTA2 Gene

GeneLoc Exon Structure for
MTA2
ECgene alternative splicing isoforms for
MTA2

Expression for MTA2 Gene

mRNA expression in normal human tissues for MTA2 Gene

Protein differential expression in normal tissues from HIPED for MTA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Breast (8.6), and Lymph node (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MTA2 Gene



Protein tissue co-expression partners for MTA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MTA2 Gene:

MTA2

SOURCE GeneReport for Unigene cluster for MTA2 Gene:

Hs.173043

mRNA Expression by UniProt/SwissProt for MTA2 Gene:

O94776-MTA2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with MTA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MTA2 Gene

Orthologs for MTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTA2 34
  • 93.04 (n)
  • 98.65 (a)
MTA2 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTA2 34
  • 93.11 (n)
  • 98.95 (a)
MTA2 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mta2 34
  • 91.17 (n)
  • 98.5 (a)
Mta2 16
Mta2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mta2 34
  • 90.52 (n)
  • 98.05 (a)
oppossum
(Monodelphis domestica)
Mammalia MTA2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTA2 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTA2 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mta2 34
  • 75.45 (n)
  • 90.36 (a)
Str.6927 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.545 34
zebrafish
(Danio rerio)
Actinopterygii mta2 34
  • 71.96 (n)
  • 81.51 (a)
wufi29g02 34
mta2 35
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MTA1-like 35
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-40 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToOne
Species where no ortholog for MTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTA2 Gene

ENSEMBL:
Gene Tree for MTA2 (if available)
TreeFam:
Gene Tree for MTA2 (if available)

Paralogs for MTA2 Gene

Paralogs for MTA2 Gene

(4) SIMAP similar genes for MTA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTA2: view

Variants for MTA2 Gene

Sequence variations from dbSNP and Humsavar for MTA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1064468 -- 62,598,607(-) CAGGG(A/G)TGTCT reference, missense
rs1136140 -- 62,594,626(-) CCCAG(A/G)CACCC reference, missense
rs34121243 -- 62,597,688(+) CTTCT(-/G)GCTGG reference, frameshift-variant
rs34385020 -- 62,597,610(+) TCACC(-/G)GGGCC reference, frameshift-variant
rs77169497 -- 62,594,691(+) TTGTT(A/G)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTA2 Gene

Variant ID Type Subtype PubMed ID
esv3579735 CNV loss 25503493
esv3584599 CNV gain 24956385
nsv514630 CNV gain 21397061
nsv555174 CNV gain 21841781
nsv825939 CNV gain 20364138
nsv832180 CNV loss 17160897
nsv832182 CNV gain+loss 17160897

Variation tolerance for MTA2 Gene

Residual Variation Intolerance Score: 3.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA2 Gene

Disorders for MTA2 Gene

Relevant External Links for MTA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTA2

No disorders were found for MTA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MTA2 Gene

Publications for MTA2 Gene

  1. Molecular cloning, mapping and characterization of a novel human gene, MTA1-L1. showing homology to a metastasis-associated gene, MTA1. (PMID: 9929979) Futamura M. … Tokino T. (J. Hum. Genet. 1999) 2 3 4 22 65
  2. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. (PMID: 22926524) Xuan C. … Shang Y. (Oncogene 2013) 3 4 65
  3. Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. (PMID: 19702911) Lee H. … Kim K.W. (J. Gastroenterol. Hepatol. 2009) 3 22 65
  4. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. (PMID: 18413351) Lee C. … Agoston D.V. (Cereb. Cortex 2008) 3 22 65
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65

Products for MTA2 Gene

Sources for MTA2 Gene

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