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MTA1 Gene

protein-coding   GIFtS: 65
GCID: GC14P105886

Metastasis Associated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metastasis Associated 11 2
Metastasis Associated Gene 1 Protein2
Metastasis-Associated Protein MTA12

External Ids:    HGNC: 74101   Entrez Gene: 91122   Ensembl: ENSG000001829797   OMIM: 6035265   UniProtKB: Q133303   

Export aliases for MTA1 gene to outside databases

Previous GC identifers: GC14U990075 GC14P099877 GC14P103858 GC14P104957 GC14P086101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MTA1 Gene:
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically,
mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of
at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in
metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase
complex, NuRD, but it is more likely that this component is a different but very similar protein. These two
proteins are so closely related, though, that they share the same types of domains. These domains include two DNA
binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile
and activity of this gene product suggest that it is involved in regulating transcription and that this may be
accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for MTA1 Gene:
MTA1 (metastasis associated 1) is a protein-coding gene. Diseases associated with MTA1 include tonsil cancer, and tonsillitis. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MTA3.

UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330
Function: May be involved in the regulation of gene expression by covalent modification of histone proteins.
Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the
cytoplasm and enhances non-genomic responses of ER

Gene Wiki entry for MTA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MTA1 gene promoter:
         Pax-5   p53   SREBP-1c   CUTL1   SREBP-1b   YY1   N-Myc   SREBP-1a   FOXC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMTA1 promoter sequence
   Search Chromatin IP Primers for MTA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MTA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

MTA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P105886:  view genomic region     (about GC identifiers)

Start:
105,886,159 bp from pter      End:
105,937,066 bp from pter
Size:
50,908 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330 (See protein sequence)
Recommended Name: Metastasis-associated protein MTA1  
Size: 715 amino acids; 80786 Da
Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts
with HDAC1 and ITGB3BP/CENPR. Binds to CSNK1G2 in the cytoplasm
Developmental stage: Highly expressed in metastatic cells
1 PDB 3D structure from and Proteopedia for MTA1:
4BKX (3D)    
Secondary accessions: A5PLK4 Q86SW2 Q8NFI8 Q96GI8
Alternative splicing: 3 isoforms:  Q13330-1   Q13330-2   Q13330-3   

Explore the universe of human proteins at neXtProt for MTA1: NX_Q13330

Explore proteomics data for MTA1 at MOPED

Post-translational modifications: 

  • Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER)1
  • Ubiquitination2 at Lys32, Lys208, Lys361, Lys527
  • Modification sites at PhosphoSitePlus

  • See MTA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001190187.1  NP_004680.2  

    ENSEMBL proteins: 
     ENSP00000333633   ENSP00000385702   ENSP00000384180   ENSP00000393438   ENSP00000450094  
     ENSP00000411493   ENSP00000448146   ENSP00000394106   ENSP00000446480   ENSP00000395371  
     ENSP00000450269   ENSP00000389425  
    Reactome Protein details: Q13330

    MTA1 Human Recombinant Protein Products:

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    OriGene MassSpec for MTA1
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    Novus Biologicals MTA1 Proteins
    Novus Biologicals MTA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MTA1

    MTA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MTA1 
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    Novus Biologicals MTA1 Antibodies
    Abcam antibodies for MTA1
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    ThermoFisher Antibodies for MTA1
    LSBio Antibodies in human, mouse, rat for MTA1

    MTA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MTA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MTA1
    Cloud-Clone Corp. CLIAs for MTA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GATAD: GATA zinc finger domain containing

    Selected InterPro protein domains (see all 6):
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR001025 BAH_dom
     IPR000679 Znf_GATA
     IPR000949 ELM2_dom

    Graphical View of Domain Structure for InterPro Entry Q13330

    ProtoNet protein and cluster: Q13330

    4 Blocks protein domains:
    IPB000679 Zn-finger
    IPB000949 ELM2 domain
    IPB001005 Myb DNA-binding domain
    IPB001025 Bromo adjacent region


    UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330
    Domain: Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif)
    Similarity: Contains 1 BAH domain
    Similarity: Contains 1 ELM2 domain
    Similarity: Contains 1 GATA-type zinc finger
    Similarity: Contains 1 SANT domain


    MTA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTA1_HUMAN, Q13330
    Function: May be involved in the regulation of gene expression by covalent modification of histone proteins.
    Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the
    cytoplasm and enhances non-genomic responses of ER

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001103RNA polymerase II repressing transcription factor binding IPI--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16511565
         
    MTA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MTA1:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mta1):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail  skeleton 
     vision/eye 

    MTA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MTA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MTA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MTA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MTA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MTA1:
    hsa-mir-559 (MIRT004442), hsa-mir-661 (MIRT000033)

    Block miRNA regulation of human, mouse, rat MTA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTA1 (see all 12):
    hsa-miR-3163 hsa-miR-1283 hsa-miR-589* hsa-miR-183 hsa-miR-452* hsa-miR-3647-3p hsa-miR-4282 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidMTA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MTA1
    Predesigned siRNA for gene silencing in human, mouse, rat MTA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MTA1

    Clone
    Products:
         
    OriGene clones in human, mouse for MTA1 (see all 6)
    OriGene ORF clones in mouse, rat for MTA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MTA1 (NM_001203258)
    Sino Biological Human cDNA Clone for MTA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MTA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MTA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTA1_HUMAN, Q13330: Isoform Short: Cytoplasm
    MTA1_HUMAN, Q13330: Isoform Long: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endoplasmic reticulum2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0016581NuRD complex IEA--

    MTA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MTA1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    RNA Polymerase I Promoter Clearance0.78
    2RNA Polymerase I Promoter Escape
    RNA Polymerase I Transcription Initiation0.55
    3Gene Expression
    Gene Expression0.40
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    5Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MTA1
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for MTA1
        Transcription Sin3 and NuRD in transcription regulation

    1 BioSystems Pathway for MTA1
        Validated targets of C-MYC transcriptional activation


    1 Reactome Pathway for MTA1
        RNA Polymerase I Transcription Initiation



    MTA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTA1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Tumor Metastasis in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MTA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MTA1 (Q133301, 2, 3 ENSP000003336334) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTA2O947762, 3, ENSP000002788234MINT-6613980 MINT-6613885 I2D: score=1 STRING: ENSP00000278823
    GPR183P322492, 3, ENSP000003655964MINT-63668 I2D: score=5 STRING: ENSP00000365596
    NELFCDQ8IXH72, 3, ENSP000003423004MINT-64857 I2D: score=5 STRING: ENSP00000342300
    HIF1AQ166651, 2, 3, ENSP000003380184EBI-714236,EBI-447269 MINT-1957363 MINT-1957385 MINT-1957313 MINT-1957331 MINT-1957284 MINT-1957260 I2D: score=3 STRING: ENSP00000338018
    HDAC1Q135471, 2, 3, ENSP000003626494EBI-714236,EBI-301834 MINT-1957435 MINT-6613980 MINT-6613731 MINT-6614075 MINT-6613885 I2D: score=4 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction TAS8083195
    GO:0033363secretory granule organization IEA--

    MTA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MTA1

    5 Novoseek inferred chemical compound relationships for MTA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 50.7 17 15116322 (2), 14613024 (1), 15226262 (1), 16309230 (1) (see all 13)
    leucine 20.2 1 10840944 (1)
    progesterone 6.34 5 15226262 (2), 16630134 (1)
    tamoxifen 2.24 2 16244788 (1)
    tyrosine 0 1 7607577 (1)



    MTA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MTA1 gene (2 alternative transcripts): 
    NM_001203258.1  NM_004689.3  

    Unigene Cluster for MTA1:

    Metastasis associated 1
    Hs.525629  [show with all ESTs]
    Unigene Representative Sequence: BC142941
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000331320(uc001yqx.3 uc001yqy.3 uc021seq.1) ENST00000406191
    ENST00000405646(uc001yra.1 uc001yrb.3) ENST00000438610(uc001yqz.1)
    ENST00000551236 ENST00000481012 ENST00000424723 ENST00000494026 ENST00000498644
    ENST00000434050 ENST00000490198 ENST00000550551 ENST00000550808 ENST00000469140
    ENST00000552286 ENST00000426567 ENST00000481206 ENST00000494981
    miRNA
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    Block miRNA regulation of human, mouse, rat MTA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MTA1 (see all 12):
    hsa-miR-3163 hsa-miR-1283 hsa-miR-589* hsa-miR-183 hsa-miR-452* hsa-miR-3647-3p hsa-miR-4282 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidMTA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MTA1
    Predesigned siRNA for gene silencing in human, mouse, rat MTA1
    Clone
    Products:
         
    OriGene clones in human, mouse for MTA1 (see all 6)
    OriGene ORF clones in mouse, rat for MTA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MTA1 (NM_001203258)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MTA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MTA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MTA1
      QuantiTect SYBR Green Assays in human, mouse, rat MTA1
      QuantiFast Probe-based Assays in human, mouse, rat MTA1

    Additional mRNA sequence: 

    AB209348.1 AF508978.1 BC006177.1 BC009443.1 BC142941.1 BX248755.1 BX248776.1 U35113.1 

    Selected DOTS entries (see all 26):

    DT.92447087  DT.449631  DT.100030352  DT.100786107  DT.95162408  DT.75166793  DT.86854793  DT.100786106 
    DT.318062  DT.100786114  DT.120794548  DT.120794631  DT.100786105  DT.100786108  DT.100769618  DT.120794600 
    DT.120794621  DT.95162401  DT.97860672  DT.121639813  DT.449633  DT.92447065  DT.92447066  DT.92447068 

    Selected AceView cDNA sequences (see all 320):

    BQ006659 AI867401 AI217513 BQ278193 AI597578 BE396820 BM988772 AI248039 
    BQ923731 BE796530 AI492194 BM552195 BM719750 BG913271 BX248755 BQ186103 
    BE796422 BM451727 AI264342 BM555008 BM926790 AI033836 BG676595 BM785137 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MTA1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:        -                 -     -     -           -                                   -                                                                     
    SP2:        -                 -     -     -           -                                   -                                               -                     
    SP3:                                -     -           -                                   -                                                                     
    SP4:                          -     -     -                                                                                                                     
    SP5:                          -     -     -     -     -                                   -                                                                     

    ExUns: 22a · 22b ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MTA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MTA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACAGAGG
    MTA1 Expression
    About this image


    MTA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
    MTA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MTA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525629

    UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330
    Tissue specificity: Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands.
    Higher in tumors than in adjacent normal tissue from the same individual

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MTA1: 
              Estrogen Receptor Signaling in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Tumor Metastasis in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MTA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mta11 , 5 metastasis associated 11, 5 89.64(n)1
    97.13(a)1
      12 (61.57 cM)5
    1168701  NM_054081.21  NP_473422.21 
     1130982785 
    chicken
    (Gallus gallus)
    Aves MTA11 metastasis associated 1 78.06(n)
    93.2(a)
      429060  NM_001012953.1  NP_001012971.1 
    lizard
    (Anolis carolinensis)
    Reptilia MTA16
    metastasis associated 1
    87(a)
    1 ↔ 1
    4(74077369-74140206)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mta11 metastasis associated 1 75.04(n)
    90.32(a)
      496581  NM_001011163.1  NP_001011163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7944771 metastasis-associated protein MTA1-like 75.51(n)
    84.42(a)
      794477  XM_005158860.1  XP_005158917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MTA1-like1 MTA1-like 56.07(n)
    55.62(a)
      40693  NM_141309.3  NP_649566.2 


    ENSEMBL Gene Tree for MTA1 (if available)
    TreeFam Gene Tree for MTA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MTA1 gene
    MTA32  MTA22  RERE2  ATN12  
    5 SIMAP similar genes for MTA1 using alignment to 10 protein entries:     MTA1_HUMAN (see all proteins):
    tmp_locus_6    MTA3    MTA2    DKFZp686F2281    RERE

    MTA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MTA1 (see all 1163)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74927961,2
    C,F,A,H--105888138(+) GCCCCA/GCACAG 2 -- int16Minor allele frequency- G:0.12NS EA CSA WA 535
    rs1177154561,2
    C,F--105888265(+) GGTGGC/GCTGGA 2 -- int11Minor allele frequency- G:0.01EA 120
    rs1879138151,2
    --105888433(+) GTGGCC/TGGGTG 2 -- int10--------
    rs284821501,2
    C,F--105888457(+) CAGGCC/TCCCCA 2 -- int12Minor allele frequency- T:0.15CSA WA 120
    rs766607651,2
    F--105888527(+) ACTCTG/CACTGT 2 -- int11Minor allele frequency- C:0.01EA 120
    rs1920194111,2
    C--105888572(+) TGGACC/TGGAAC 2 -- int10--------
    rs1447270421,2
    C--105888659(+) GTGCTC/TGCTCG 2 -- int10--------
    rs589317081,2
    C--105893408(+) CCTGCC/TGCACA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs101445831,2
    C,F,H--105893411(+) GCCGCG/ACAGCT 2 -- int116Minor allele frequency- A:0.18NS NA WA CSA EA 1165
    rs1484715181,2
    --105893520(+) CACACG/TTATGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MTA1 (105886159 - 105937066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MTA1 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749293CNV Deletion23290073
    esv2749295CNV Deletion23290073
    esv2749297CNV Deletion23290073
    esv2749294CNV Deletion23290073
    esv1158347CNV Deletion17803354
    esv1287990CNV Insertion17803354
    esv998455CNV Insertion20482838
    esv996317CNV Insertion20482838
    nsv85362CNV Insertion16902084
    esv999483CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603526    OMIM disorders: --

    Selected diseases for MTA1 (see all 40):    
    About MalaCards
    tonsil cancer    tonsillitis    adenocarcinoma    cancer progression/metastasis
    laryngeal carcinoma    laryngitis    pancreatic endocrine tumors    endometrial adenocarcinoma
    thymoma    laryngeal squamous cell carcinoma    esophagitis    barrett's esophagus
    neuroendocrine tumor    hepatitis b    squamous cell carcinoma    brain cancer
    hepatocellular carcinoma    nasopharyngitis    ovarian cancer    esophageal squamous cell carcinoma


    MTA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MTA1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nonmetastatic 71.6 6 10840944 (1), 8083195 (1), 12650603 (1), 7607577 (1) (see all 6)
    metastasis 65.5 120 11783065 (7), 12599421 (5), 16196299 (5), 14515783 (4) (see all 49)
    carcinoid 56 9 16424981 (2), 16794389 (2), 16537680 (1), 19115524 (1) (see all 7)
    breast cancer 51.7 44 19087679 (5), 16630134 (3), 16617102 (2), 11325822 (2) (see all 22)
    tumors 47.4 89 16630134 (7), 16244788 (6), 9291440 (4), 16733204 (4) (see all 41)
    cancer 45.7 64 17914590 (4), 18719363 (4), 16969516 (4), 17868030 (4) (see all 29)
    ovarian carcinoma 42.7 11 12903788 (3), 11783065 (2), 12650603 (1), 12478894 (1) (see all 6)
    esophageal carcinoma 41.6 7 10206283 (3), 18359692 (2), 10840944 (1), 12684630 (1)
    primary tumor 39.8 2 16424981 (1), 16831056 (1)
    ovarian cancer 36.8 13 18719363 (5), 18836297 (1), 19363681 (1)

    Genetic Association Database (GAD): MTA1
    Human Genome Epidemiology (HuGE) Navigator: MTA1 (2 documents)

    Export disorders for MTA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MTA1 gene, integrated from 10 sources (see all 215):
    (articles sorted by number of sources associating them with MTA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. (PubMed id 8083195)1, 2, 3, 9 Toh Y.... Nicolson G.L. (J. Biol. Chem. 1994)
    2. Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines. (PubMed id 7607577)1, 2, 3, 9 Toh Y.... Nicolson G.L. (Gene 1995)
    3. Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. (PubMed id 10967548)1, 4, 9 Nawa A....Nicolson G.L. (J. Cell. Biochem. 2000)
    4. A naturally occurring MTA1 variant sequesters oestrogen receptor- alpha in the cytoplasm. (PubMed id 12167865)1, 2, 9 Kumar R....Vadlamudi R.K. (Nature 2002)
    5. Breast cancer risk associated with genotypic polymorphism of the genes involved in the estrogen-receptor-signaling pathway: a multigenic study on cancer susceptibility. (PubMed id 16502042)1, 4, 9 Yu J.C....Shen C.Y. (J. Biomed. Sci. 2006)
    6. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. (PubMed id 9885572)1, 2, 9 Xue Y.... Wang W. (Mol. Cell 1998)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Metastasis-associated protein 1 interacts with NRIF3, an estrogen- inducible nuclear receptor coregulator. (PubMed id 15254226)1, 2 Talukder A.H.... Kumar R. (Mol. Cell. Biol. 2004)
    10. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PubMed id 15077195)1, 2 Mishra S.K.... Kumar R. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9112 HGNC: 7410 AceView: MTA1 Ensembl:ENSG00000182979 euGenes: HUgn9112
    ECgene: MTA1 H-InvDB: MTA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MTA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MTA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MTA1 gene:
    Search GeneIP for patents involving MTA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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