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Aliases for MTA1 Gene

Aliases for MTA1 Gene

  • Metastasis Associated 1 2 3

External Ids for MTA1 Gene

Previous GeneCards Identifiers for MTA1 Gene

  • GC14U990075
  • GC14P099877
  • GC14P103858
  • GC14P104957
  • GC14P105886
  • GC14P086101

Summaries for MTA1 Gene

Entrez Gene Summary for MTA1 Gene

  • This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MTA1 Gene

MTA1 (Metastasis Associated 1) is a Protein Coding gene. Diseases associated with MTA1 include tonsil cancer and adenocarcinoma. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is RERE.

UniProtKB/Swiss-Prot for MTA1 Gene

  • Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.

Gene Wiki entry for MTA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTA1 Gene

Genomics for MTA1 Gene

Regulatory Elements for MTA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MTA1 Gene

Start:
105,419,820 bp from pter
End:
105,470,729 bp from pter
Size:
50,910 bases
Orientation:
Plus strand

Genomic View for MTA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTA1 Gene

Proteins for MTA1 Gene

  • Protein details for MTA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13330-MTA1_HUMAN
    Recommended name:
    Metastasis-associated protein MTA1
    Protein Accession:
    Q13330
    Secondary Accessions:
    • A5PLK4
    • Q86SW2
    • Q8NFI8
    • Q96GI8

    Protein attributes for MTA1 Gene

    Size:
    715 amino acids
    Molecular mass:
    80786 Da
    Quaternary structure:
    • Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR. Binds to CSNK1G2 in the cytoplasm. Interacts with NACC2. Interacts with ARNTL/BMAL1 and CLOCK. Interacts with EP300, TFAP2C, IFI16, TPR, HDAC2, UBE2I/UBC9, PIAS1, PIAS3, PIAS4, p53/TP53, MDM2, RFWD2, SUMO1, SUMO2, SENP1 and SENP2. Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter (By similarity).

    Three dimensional structures from OCA and Proteopedia for MTA1 Gene

    Alternative splice isoforms for MTA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTA1 Gene

Proteomics data for MTA1 Gene at MOPED

Post-translational modifications for MTA1 Gene

  • Acetylation is essential for its transcriptional coactivator activity.
  • Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).
  • Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1.
  • Ubiquitinated by RFWD2, which leads to proteasomal degradation.
  • Ubiquitination at Lys32, Lys208, Lys361, Lys527, and Lys61
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MTA1 (MTA1)

No data available for DME Specific Peptides for MTA1 Gene

Domains for MTA1 Gene

Gene Families for MTA1 Gene

HGNC:
  • GATAD :GATA zinc finger domain containing

Suggested Antigen Peptide Sequences for MTA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13330

UniProtKB/Swiss-Prot:

MTA1_HUMAN :
  • Q13330
Domain:
  • Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif)
  • Contains 1 BAH domain.
  • Contains 1 ELM2 domain.
  • Contains 1 SANT domain.
Similarity:
  • Contains 1 GATA-type zinc finger.
genes like me logo Genes that share domains with MTA1: view

Function for MTA1 Gene

Molecular function for MTA1 Gene

UniProtKB/Swiss-Prot Function: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.

Gene Ontology (GO) - Molecular Function for MTA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001047 core promoter binding IDA 21965678
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with MTA1: view
genes like me logo Genes that share phenotypes with MTA1: view

Animal Model Products

CRISPR Products

miRNA for MTA1 Gene

miRTarBase miRNAs that target MTA1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MTA1 Gene

Localization for MTA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTA1 Gene

Isoform Short: Cytoplasm.
Isoform Long: Nucleus. Nucleus envelope. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Localization at the nuclear envelope is TPR-dependent.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTA1 Gene COMPARTMENTS Subcellular localization image for MTA1 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for MTA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21965678
GO:0005635 nuclear envelope IDA 24970816
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IDA 24970816
genes like me logo Genes that share ontologies with MTA1: view

Pathways for MTA1 Gene

genes like me logo Genes that share pathways with MTA1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MTA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IMP 19805145
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8083195
genes like me logo Genes that share ontologies with MTA1: view

Compounds for MTA1 Gene

(5) Novoseek inferred chemical compound relationships for MTA1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 50.7 14
leucine 20.2 1
progesterone 6.34 3
tamoxifen 2.24 1
tyrosine 0 1
genes like me logo Genes that share compounds with MTA1: view

Transcripts for MTA1 Gene

Unigene Clusters for MTA1 Gene

Metastasis associated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MTA1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MTA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MTA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: -
SP9: -
SP10:

ExUns: 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for MTA1 Gene

GeneLoc Exon Structure for
MTA1
ECgene alternative splicing isoforms for
MTA1

Expression for MTA1 Gene

mRNA expression in normal human tissues for MTA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTA1 Gene

SOURCE GeneReport for Unigene cluster for MTA1 Gene Hs.525629

mRNA Expression by UniProt/SwissProt for MTA1 Gene

Q13330-MTA1_HUMAN
Tissue specificity: Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis.
genes like me logo Genes that share expressions with MTA1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MTA1 Gene

Orthologs for MTA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTA1 35
  • 99.01 (n)
  • 98.87 (a)
cow
(Bos Taurus)
Mammalia MTA1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTA1 35
  • 91.93 (n)
  • 97.45 (a)
MTA1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mta1 35
  • 89.64 (n)
  • 97.13 (a)
Mta1 16
Mta1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTA1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTA1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mta1 35
  • 89.43 (n)
  • 97.16 (a)
chicken
(Gallus gallus)
Aves MTA1 35
  • 78.06 (n)
  • 93.2 (a)
MTA1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTA1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mta1 35
  • 75.04 (n)
  • 90.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC794477 35
  • 75.51 (n)
  • 84.42 (a)
MTA1 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004341 35
  • 57.8 (n)
  • 60.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta MTA1-like 35
  • 56.07 (n)
  • 55.62 (a)
worm
(Caenorhabditis elegans)
Secernentea egr-1 37
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1613 35
Species with no ortholog for MTA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTA1 Gene

ENSEMBL:
Gene Tree for MTA1 (if available)
TreeFam:
Gene Tree for MTA1 (if available)

Paralogs for MTA1 Gene

Paralogs for MTA1 Gene

genes like me logo Genes that share paralogs with MTA1: view

Variants for MTA1 Gene

Sequence variations from dbSNP and Humsavar for MTA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13707 - 105,469,487(+) GACAG(A/G)CCAGG utr-variant-3-prime, missense, reference
rs1132321 -- 105,464,821(+) CGCGG(A/C)ACCCC utr-variant-3-prime, missense, reference
rs1132457 -- 105,470,530(+) TTCTG(A/G/T)TGAAG utr-variant-3-prime
rs3936032 -- 105,456,726(+) TGGGT(C/G)ACACC intron-variant
rs4074000 -- 105,457,604(+) CTTGC(A/C)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTA1 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
dgv659e1 CNV Complex 17122850
nsv470679 CNV Loss 18288195
nsv902441 CNV Loss 21882294
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
nsv902473 CNV Loss 21882294
nsv832890 CNV Loss 17160897
nsv817647 CNV Gain 17921354
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
esv2749293 CNV Deletion 23290073
esv2749294 CNV Deletion 23290073
dgv2036n71 CNV Loss 21882294
nsv84553 CNV Insertion 16902084
esv999483 CNV Insertion 20482838
esv1287990 CNV Insertion 17803354
dgv2037n71 CNV Loss 21882294
esv998455 CNV Insertion 20482838
esv996317 CNV Insertion 20482838
esv1257424 CNV Insertion 17803354
nsv85362 CNV Insertion 16902084
dgv2038n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv827088 CNV Gain 20364138
esv2749295 CNV Deletion 23290073
nsv902492 CNV Loss 21882294
esv1158347 CNV Deletion 17803354
esv2749297 CNV Deletion 23290073
dgv2039n71 CNV Loss 21882294

Relevant External Links for MTA1 Gene

HapMap Linkage Disequilibrium report
MTA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTA1 Gene

Disorders for MTA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MTA1 Gene including...

Search for MTA1 Gene in MalaCards »

(24) Novoseek inferred disease relationships for MTA1 Gene

Disease -log(P) Hits PubMed IDs
nonmetastatic 71.6 6
metastasis 65.5 88
carcinoid 56 9
breast cancer 51.7 32
tumors 47.4 71

Relevant External Links for MTA1

Genetic Association Database (GAD)
MTA1
Human Genome Epidemiology (HuGE) Navigator
MTA1
genes like me logo Genes that share disorders with MTA1: view

No data available for UniProtKB/Swiss-Prot for MTA1 Gene

Publications for MTA1 Gene

  1. Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines. (PMID: 7607577) Toh Y. … Nicolson G.L. (Gene 1995) 2 3 4 23
  2. A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. (PMID: 8083195) Toh Y. … Nicolson G.L. (J. Biol. Chem. 1994) 2 3 4 23
  3. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. (PMID: 9885572) Xue Y. … Wang W. (Mol. Cell 1998) 3 4 23
  4. Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. (PMID: 10967548) Nawa A. … Nicolson G.L. (J. Cell. Biochem. 2000) 3 23 48
  5. A naturally occurring MTA1 variant sequesters oestrogen receptor- alpha in the cytoplasm. (PMID: 12167865) Kumar R. … Vadlamudi R.K. (Nature 2002) 3 4 23

Products for MTA1 Gene

Sources for MTA1 Gene

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