MTA1 Gene
protein-coding GIFtS: 63
GCID: GC14P105886
|
|
metastasis associated 1
| |
Aliases
for MTA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Metastasis Associated 11 2 | | Metastasis Associated Gene 1 Protein2 | | Metastasis-Associated Protein MTA12 |
Export aliases for MTA1 gene to outside databasesPrevious GC identifers: GC14U990075 GC14P099877 GC14P103858 GC14P104957 GC14P086101 |
Summaries
for MTA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MTA1:
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically,mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of atleast two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis isunclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, butit is more likely that this component is a different but very similar protein. These two proteins are so closelyrelated, though, that they share the same types of domains. These domains include two DNA binding domains, adimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this geneproduct suggest that it is involved in regulating transcription and that this may be accomplished by chromatinremodeling. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,Feb 2011)
UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330Function: May be involved in the regulation of gene expression by covalent modification of histone proteins. IsoformLong is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm andenhances non-genomic responses of ER
Gene Wiki entry for MTA1
|
Genomic Views
for MTA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MTA1 gene promoter:
Pax-5 p53 SREBP-1c CUTL1 SREBP-1b YY1 N-Myc SREBP-1a FOXC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MTA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33MTA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P105886: view genomic region
(about GC identifiers)
Start:
|
105,886,159 bp from pter |
End:
|
105,937,066 bp from pter |
Size:
|
50,908 bases |
Orientation:
|
plus strand |
|
Proteins
for MTA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330 (See
protein sequence)Recommended Name: Metastasis-associated protein MTA1 Size: 715 amino acids; 80786 Da
Subunit: Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts withHDAC1 and ITGB3BP/CENPR. Binds to CSNK1G2 in the cytoplasm
Subcellular location: Isoform Short: Cytoplasm
Subcellular location: Isoform Long: Nucleus
Developmental stage: Highly expressed in metastatic cells
Secondary accessions: A5PLK4 Q86SW2 Q8NFI8 Q96GI8Alternative splicing: 3 isoforms: Q13330-1 Q13330-2 Q13330-3 Explore the universe of human proteins at neXtProt for MTA1: NX_Q13330
Post-translational modifications:
Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13330
MTA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001190187.1 NP_004680.2
ENSEMBL proteins: ENSP00000333633 ENSP00000385702 ENSP00000384180 ENSP00000393438 ENSP00000450094 ENSP00000411493 ENSP00000448146 ENSP00000394106 ENSP00000446480 ENSP00000395371 ENSP00000450269 ENSP00000389425
Human Recombinant Protein Products for MTA1:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
MTA1 for ontologies About GeneDecksing
MTA1 Antibody Products:
Assay Products for MTA1: |
Protein
Domains /
Families
for MTA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MTA1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13330ProtoNet protein and cluster: Q13330 4 Blocks protein families: IPB000679 Zn-finger IPB000949 ELM2 domain IPB001005 Myb DNA-binding domain IPB001025 Bromo adjacent region
UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330Domain: Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif)Similarity: Contains 1 BAH domainSimilarity: Contains 1 ELM2 domainSimilarity: Contains 1 GATA-type zinc fingerSimilarity: Contains 1 SANT domain |
Function
for MTA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MTA1_HUMAN, Q13330Function: May be involved in the regulation of gene expression by covalent modification of histone proteins. IsoformLong is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm andenhances non-genomic responses of ER Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001103 | RNA polymerase II repressing transcription factor binding |
IPI | -- | | GO:0003677 | DNA binding |
-- | -- | | GO:0003682 | chromatin binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
MTA1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MTA1:
10 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mta1):
MTA1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTA1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MTA1 (NM_001203258) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA1 |
|
Pathways & Interactions
for MTA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Sin3 and NuRD in transcription regulation | | | 2 | Validated targets of C-MYC transcriptional activation | | | 3 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MTA1
1 
Cell Signaling Technology (CST) Pathway for MTA1
1  GeneGo (Thomson Reuters) Pathway for MTA1
1  BioSystems Pathway for MTA1
MTA1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MTA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/95 Interacting proteins for MTA1 (Q133302, 3 ENSP000003336334) via UniProtKB, MINT, STRING, and/or I2D (see all 95)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MTA2 | O947762, 3, ENSP000002788234 | MINT-6613980 MINT-6613885 I2D:
score=1 STRING: ENSP00000278823 | | GPR183 | P322492, 3, ENSP000003655964 | MINT-63668 I2D:
score=5 STRING: ENSP00000365596 | | NELFCD | Q8IXH72, 3, ENSP000003423004 | MINT-64857 I2D:
score=5 STRING: ENSP00000342300 | | HIF1A | Q166652, 3, ENSP000003380184 | MINT-1957363 MINT-1957385 MINT-1957313 MINT-1957331 MINT-1957284 MINT-1957260 I2D:
score=3 STRING: ENSP00000338018 | | HDAC1 | Q135472, 3, ENSP000003626494 | MINT-1957435 MINT-6613980 MINT-6613731 MINT-6614075 MINT-6613885 I2D:
score=4 STRING: ENSP00000362649 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MTA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MTA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MTA1 for compounds About GeneDecksing
 Browse Tocris compounds for MTA1
5 Novoseek chemical compound relationships for MTA1 gene About this table
Search CenterWatch for drugs/clinical trials and news about MTA1
|
Transcripts
for MTA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MTA1 gene (2 alternative transcripts): NM_001203258.1 NM_004689.3 Unigene Cluster for MTA1: Metastasis associated 1 Hs.525629 [show with all ESTs]Unigene Representative Sequence: BC14294118/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000331320(uc001yqx.3 uc001yqy.3 uc021seq.1) ENST00000406191
ENST00000405646(uc001yra.1 uc001yrb.3) ENST00000438610(uc001yqz.1)
ENST00000551236 ENST00000485203 ENST00000481012 ENST00000424723 ENST00000494026
ENST00000498644 ENST00000434050 ENST00000552860 ENST00000490198 ENST00000550551
ENST00000550808 ENST00000469140 ENST00000552286 ENST00000426567
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTA1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MTA1 (NM_001203258) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MTA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA1 |
Additional cDNA sequence: AB209348.1 AF508978.1 BC006177.1 BC009443.1 BC142941.1 BX248755.1 BX248776.1 U35113.1 24/26 DOTS entries (see all 26): DT.92447087 DT.449631 DT.100030352 DT.100786107 DT.95162408 DT.75166793 DT.86854793 DT.100786106 DT.318062 DT.100786114 DT.120794548 DT.120794631 DT.100786105 DT.100786108 DT.100769618 DT.120794600 DT.120794621 DT.95162401 DT.97860672 DT.121639813 DT.449633 DT.92447065 DT.92447066 DT.92447068 24/320 AceView cDNA sequences (see all 320): BQ923731 BQ102354 AI248039 BM988772 BC015572 BE396820 AW162408 BQ086259 BX103185 BQ186777 BM724710 AI291147 AI497980 AW732089 BC009212 BQ186056 BX378619 AI810719 BU528394 BC006177 AI057099 BM552751 BM719750 AW204854
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for MTA1 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | - | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for MTA1
|
Expression
for MTA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MTA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACAGAGG
About this image
See MTA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MTA1
SOURCE GeneReport for Unigene cluster: Hs.525629
UniProtKB/Swiss-Prot: MTA1_HUMAN, Q13330Tissue specificity: Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands.Higher in tumors than in adjacent normal tissue from the same individual
SABiosciences Expression via Pathway-Focused PCR Arrays including MTA1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MTA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA1 |
Orthologs
for MTA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MTA1 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for MTA1 (if available)
TreeFam Gene Tree for MTA1 (if available) |
Paralogs
for MTA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MTA1 gene
- MTA32 RERE2 MTA22 ATN12
5 SIMAP similar genes for MTA1 using alignment to 10 protein entries: MTA1_HUMAN (see all proteins):tmp_locus_6 MTA3 MTA2 DKFZp686F2281 RERE
MTA1 for paralogs About GeneDecksing
|
Genomic Variants
for MTA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MTA1 (105886159 - 105937066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MTA1
5 CNVs: 3950 29968 4849 9734 29965
1 Indel: 25362 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTA1 |
|
Disorders
/ Diseases
for MTA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MTA1 for disorders About GeneDecksing
OMIM gene information: 603526
OMIM disorders: --
20/42  diseases for MTA1 (see all 42): About MalaCardsadenocarcinoma carcinoma squamous cell carcinoma cancer progression/metastasis
b-cell lymphomas barrett's esophagus laryngeal squamous cell carcinoma oral squamous cell carcinoma
esophageal squamous cell carcinoma pancreatic endocrine tumors laryngitis laryngeal carcinoma
tonsillitis hepatitis b neuroendocrine tumor esophagitis
esophageal carcinoma tonsil cancer hepatocellular carcinoma ovarian carcinoma
1 disease from the University of Copenhagen DISEASES database for MTA1:Tonsil cancer 10/24 Novoseek disease relationships for MTA1 gene (see all 24) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nonmetastatic |
71.6 |
6 |
10840944 (1), 8083195 (1), 12650603 (1), 7607577 (1) (see all 6) |
| metastasis |
65.5 |
120 |
11783065 (7), 12599421 (5), 16196299 (5), 14515783 (4) (see all 49) |
| carcinoid |
56 |
9 |
16424981 (2), 16794389 (2), 16537680 (1), 19115524 (1) (see all 7) |
| breast cancer |
51.7 |
44 |
19087679 (5), 16630134 (3), 16617102 (2), 11325822 (2) (see all 22) |
| tumors |
47.4 |
89 |
16630134 (7), 16244788 (6), 9291440 (4), 16733204 (4) (see all 41) |
| cancer |
45.7 |
64 |
17914590 (4), 18719363 (4), 16969516 (4), 17868030 (4) (see all 29) |
| ovarian carcinoma |
42.7 |
11 |
12903788 (3), 11783065 (2), 12650603 (1), 12478894 (1) (see all 6) |
| esophageal carcinoma |
41.6 |
7 |
10206283 (3), 18359692 (2), 10840944 (1), 12684630 (1) |
| primary tumor |
39.8 |
2 |
16424981 (1), 16831056 (1) |
| ovarian cancer |
36.8 |
13 |
18719363 (5), 18836297 (1), 19363681 (1) |
Genetic Association Database (GAD): MTA1
Human Genome Epidemiology (HuGE) Navigator: MTA1 (2 documents)
Export disorders for MTA1 gene to outside databases
|
Publications
for MTA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MTA1 gene, integrated from 9 sources (see all 195):
(articles sorted by number of sources associating them with MTA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. (PubMed id 8083195)1, 2, 3, 9 Toh Y.... Nicolson G.L. (1994)
- Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines. (PubMed id 7607577)1, 2, 3, 9 Toh Y.... Nicolson G.L. (1995)
- Tumor metastasis-associated human MTA1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. (PubMed id 10967548)1, 4, 9 Nawa A....Nicolson G.L. (2000)
- A naturally occurring MTA1 variant sequesters oestrogen receptor- alpha in the cytoplasm. (PubMed id 12167865)1, 2, 9 Kumar R....Vadlamudi R.K. (2002)
- NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. (PubMed id 9885572)1, 2, 9 Xue Y.... Wang W. (1998)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Metastasis-associated protein 1 interacts with NRIF3, an estrogen- inducible nuclear receptor coregulator. (PubMed id 15254226)1, 2 Talukder A.H.... Kumar R. (2004)
- Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PubMed id 15077195)1, 2 Mishra S.K....Kumar R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
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External Searches for MTA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MTA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing MTA1 gene
(According to HUGE)
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Specialized Databases showing MTA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for MTA1 gene:
Search GeneIP for patents involving MTA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MTA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for MTA1 | | OriGene shRNA RFP for MTA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MTA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MTA1 | | | OriGene Protein Over-expression Lysate for MTA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MTA1 | | OriGene 3'-UTR Clone for MTA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MTA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MTA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MTA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MTA1 | | OriGene Custom Protein Services for MTA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MTA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MTA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MTA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MTA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MTA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MTA1 |
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| | Antibodies & Assays for MTA1 |
| | | | Search Tocris compounds for MTA1 |
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 | | | MTA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MTA1 |
|  |  |  |  | | | | ThermoFisher Antibodies for MTA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MTA1 |
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