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MT4 Gene

protein-coding   GIFtS: 46
GCID: GC16P056598

Metallothionein 4

(Previous name: metallothionein IV)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein 41 2     MTIV2 5
Metallothionein IV1 2     metallothionein-42
MT-42 3     metallothionein-IV2
MT-IV2 3     Metallothionein-IV3

External Ids:    HGNC: 187051   Entrez Gene: 845602   Ensembl: ENSG000001028917   OMIM: 6062065   UniProtKB: P479443   

Export aliases for MT4 gene to outside databases

Previous GC identifers: GC16P046982 GC16P056650 GC16P056333 GC16P056374 GC16P055156 GC16P042469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT4 Gene:
MT4 (metallothionein 4) is a protein-coding gene. Diseases associated with MT4 include wernicke-korsakoff syndrome, and hepatocellular carcinoma. GO annotations related to this gene include copper ion binding.

UniProtKB/Swiss-Prot: MT4_HUMAN, P47944
Function: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the
differentiation of stratified epithelia




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT4 gene promoter:
         TBP   SRY   IRF-2   NF-1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT4 promoter sequence
   Search Chromatin IP Primers for MT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056598:  view genomic region     (about GC identifiers)

Start:
56,598,961 bp from pter      End:
56,602,869 bp from pter
Size:
3,909 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: MT4_HUMAN, P47944 (See protein sequence)
Recommended Name: Metallothionein-4  
Size: 62 amino acids; 6509 Da
Secondary accessions: Q14DA1

Explore the universe of human proteins at neXtProt for MT4: NX_P47944

Explore proteomics data for MT4 at MOPED


See MT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_116324.1  
ENSEMBL proteins: 
 ENSP00000219162  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MT: Metallothioneins

4 InterPro protein domains:
 IPR000006 Metalthion_vert
 IPR003019 Metalthion_sfam_euk
 IPR023587 Metalthion_dom_vert
 IPR017854 Metalthion_dom

Graphical View of Domain Structure for InterPro Entry P47944

ProtoNet protein and cluster: P47944

UniProtKB/Swiss-Prot: MT4_HUMAN, P47944
Similarity: Belongs to the metallothionein superfamily. Type 1 family


MT4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MT4_HUMAN, P47944
Function: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the
differentiation of stratified epithelia

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005507copper ion binding ----
GO:0008270zinc ion binding ----
GO:0046872metal ion binding IEA--
     
MT4 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1
mitochondrion1
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----

MT4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT4
Interactions:

    Search GeneGlobe Interaction Network for MT4

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006875cellular metal ion homeostasis IEA--
GO:0008150biological_process ND--

MT4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MT4

1 HMDB Compound for MT4    About this table
CompoundSynonyms CAS #PubMed Ids
CopperCu (see all 2)7440-50-8--

2 Novoseek inferred chemical compound relationships for MT4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 49 3 16556599 (2), 8003488 (1)
copper 26.6 1 16556599 (1)



MT4 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MT4 gene: 
NM_032935.2  

Unigene Cluster for MT4:

Metallothionein 4
Hs.567624
Unigene Representative Sequence: BC113442
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000219162(uc002eje.1)
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Additional mRNA sequence: 

BC113442.1 BC113444.1 

1 DOTS entry:

DT.99949145 

1 AceView cDNA sequence:

NM_032935 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAGCCATCC
MT4 Expression
About this image


MT4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Epithelial Cells
         Fetal Matrix Cells Hair Follicle
 
 Hair (Integumentary System)
         Fetal Matrix Cells Hair Follicle
MT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MT4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.567624
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MT4 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mt45 metallothionein 4   --   8 (46.26 cM) 94137204 


ENSEMBL Gene Tree for MT4 (if available)
TreeFam Gene Tree for MT4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MT4 gene
11 SIMAP similar genes for MT4 using alignment to 1 protein entry:     MT4_HUMAN:
MT1G    MT1E    MT1L    MT1H    MT1F    MT1A
MT2A    MT1B    MT1X    MTE    MT3

MT4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MT4 (see all 183)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs99277711,2
C,F,H--42467118(+) AAGATG/AGATCC 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 538
rs1838122321,2
C--42467182(+) ATGTCC/TTCCCA 1 -- us2k10--------
rs125975271,2
C,F,H--42467214(+) TTTTAC/TTCATC 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 422
rs99413091,2
C,F,A,H--42467278(+) ATACAA/TGTCCC 1 -- us2k121Minor allele frequency- N:0.00EA NA NS WA 1426
rs2822311,2
C,F,A,H--42467337(+) ACAGTA/GTTGCC 1 -- us2k111Minor allele frequency- G:0.10NS EA NA CSA WA 786
rs2822321,2
C,F,H--42467413(+) TCCTCA/GTTAGA 1 -- us2k125Minor allele frequency- G:0.18NS EA NA WA CSA 1359
rs1889292391,2
--42467484(+) GGTGAA/CTGATG 1 -- us2k10--------
rs21133151,2
C,F,O,A,H--42467490(+) TGATGG/AAGACC 1 -- us2k133Minor allele frequency- A:0.50NA NS EA WA CSA 3267
rs99307701,2
C,F,H--42467504(+) CCAAGC/TTGAGA 1 -- us2k14Minor allele frequency- T:0.02NS EA 420
rs1915237231,2
--42467525(+) ATGATC/TTCCAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MT4 (56598961 - 56602869 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MT4:    About this table    
Variant IDTypeSubtypePubMed ID
esv2714513CNV Deletion23290073
esv2714514CNV Deletion23290073
nsv906719CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606206    OMIM disorders: --

4 diseases for MT4:    
About MalaCards
wernicke-korsakoff syndrome    hepatocellular carcinoma    hiv-1    squamous cell carcinoma


MT4 for disorders           About GeneDecksing

Genetic Association Database (GAD): MT4
Human Genome Epidemiology (HuGE) Navigator: MT4 (3 documents)

Export disorders for MT4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MT4 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with MT4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. (PubMed id 8003488)1, 2, 3, 9 Quaife C.J.... Palmiter R.D. (Biochemistry 1994)
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  3. The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers. (PubMed id 19921116)1, 4 Chen H.I....Chuang H.Y. (Biol Trace Elem Res 2010)
  4. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PubMed id 19515364)1, 4 Gundacker C....Gencik M. (Environ. Res. 2009)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
  7. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)1 Izmailova E....Aldovini A. (Nat. Med. 2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. (PubMed id 16556599)9 Meloni G....VasA!k M. (J. Biol. Chem. 2006)
  10. Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. (PubMed id 11246971)9 Sogawa C.A....Ogawa N. (Acta Med. Okayama 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84560 HGNC: 18705 AceView: MT4 Ensembl:ENSG00000102891 euGenes: HUgn84560
ECgene: MT4 H-InvDB: MT4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MT4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MT4 gene:
Search GeneIP for patents involving MT4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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