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Aliases for MT4 Gene

Aliases for MT4 Gene

  • Metallothionein 4 2 3
  • Metallothionein IV 2 3
  • Metallothionein-IV 3 4
  • MT-IV 3 4
  • MT-4 3 4
  • MTIV 3

External Ids for MT4 Gene

Previous GeneCards Identifiers for MT4 Gene

  • GC16P046982
  • GC16P056650
  • GC16P056333
  • GC16P056374
  • GC16P055156
  • GC16P056598
  • GC16P042469

Summaries for MT4 Gene

GeneCards Summary for MT4 Gene

MT4 (Metallothionein 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MT4 Gene

  • Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT4 Gene

Genomics for MT4 Gene

Regulatory Elements for MT4 Gene

Genomic Location for MT4 Gene

Chromosome:
16
Start:
56,565,049 bp from pter
End:
56,568,957 bp from pter
Size:
3,909 bases
Orientation:
Plus strand

Genomic View for MT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT4 Gene

Proteins for MT4 Gene

  • Protein details for MT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47944-MT4_HUMAN
    Recommended name:
    Metallothionein-4
    Protein Accession:
    P47944
    Secondary Accessions:
    • Q14DA1

    Protein attributes for MT4 Gene

    Size:
    62 amino acids
    Molecular mass:
    6509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MT4 Gene

Proteomics data for MT4 Gene at MOPED

Post-translational modifications for MT4 Gene

No Post-translational modifications

Other Protein References for MT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT4 Gene

Domains & Families for MT4 Gene

Gene Families for MT4 Gene

Protein Domains for MT4 Gene

Suggested Antigen Peptide Sequences for MT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47944

UniProtKB/Swiss-Prot:

MT4_HUMAN :
  • Belongs to the metallothionein superfamily. Type 1 family.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT4: view

Function for MT4 Gene

Molecular function for MT4 Gene

UniProtKB/Swiss-Prot Function:
Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia

Gene Ontology (GO) - Molecular Function for MT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT4: view

Phenotypes for MT4 Gene

GenomeRNAi human phenotypes for MT4:
genes like me logo Genes that share phenotypes with MT4: view

miRNA for MT4 Gene

miRTarBase miRNAs that target MT4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MT4 Gene

Localization for MT4 Gene

Gene Ontology (GO) - Cellular Components for MT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with MT4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MT4 Gene

Pathways & Interactions for MT4 Gene

SuperPathways for MT4 Gene

No Data Available

Interacting Proteins for MT4 Gene

Gene Ontology (GO) - Biological Process for MT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006875 cellular metal ion homeostasis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MT4: view

No data available for Pathways by source and SIGNOR curated interactions for MT4 Gene

Drugs & Compounds for MT4 Gene

(2) Drugs for MT4 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Copper Pharma 143
genes like me logo Genes that share compounds with MT4: view

Transcripts for MT4 Gene

mRNA/cDNA for MT4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT4 Gene

Metallothionein 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT4 Gene

No ASD Table

Relevant External Links for MT4 Gene

GeneLoc Exon Structure for
MT4
ECgene alternative splicing isoforms for
MT4

Expression for MT4 Gene

mRNA expression in normal human tissues for MT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x28.1) and Skin - Sun Exposed (Lower leg) (x19.6).

SOURCE GeneReport for Unigene cluster for MT4 Gene Hs.567624

genes like me logo Genes that share expression patterns with MT4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MT4 Gene

Orthologs for MT4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT4 35
  • 98.92 (n)
  • 98.39 (a)
MT4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mt4 16
Mt4 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT4 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MT4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MT4 36
  • 83 (a)
OneToOne
Species with no ortholog for MT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT4 Gene

ENSEMBL:
Gene Tree for MT4 (if available)
TreeFam:
Gene Tree for MT4 (if available)

Paralogs for MT4 Gene

(11) SIMAP similar genes for MT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT4: view

No data available for Paralogs for MT4 Gene

Variants for MT4 Gene

Sequence variations from dbSNP and Humsavar for MT4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_034110 -
VAR_034111 -
VAR_034112 -

Structural Variations from Database of Genomic Variants (DGV) for MT4 Gene

Variant ID Type Subtype PubMed ID
nsv906719 CNV Gain 21882294
esv2714513 CNV Deletion 23290073
esv2714514 CNV Deletion 23290073

Variation tolerance for MT4 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT4 Gene

HapMap Linkage Disequilibrium report
MT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT4 Gene

Disorders for MT4 Gene

Relevant External Links for MT4

Genetic Association Database (GAD)
MT4
Human Genome Epidemiology (HuGE) Navigator
MT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT4
genes like me logo Genes that share disorders with MT4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT4 Gene

Publications for MT4 Gene

  1. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. (PMID: 8003488) Quaife C.J. … Palmiter R.D. (Biochemistry 1994) 2 23 67
  2. Loss of 13q is associated with genes involved in cell cycle and proliferation in dedifferentiated hepatocellular carcinoma. (PMID: 18820673) Skawran B. … Wilkens L. (Mod. Pathol. 2008) 23 67
  3. Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. (PMID: 16556599) Meloni G. … VasA!k M. (J. Biol. Chem. 2006) 23 67
  4. Metallothioneins and zinc: their functions and interactions. (PMID: 15535115) Hijova E. (Bratisl Lek Listy 2004) 23 67
  5. Increased metallothionein in light damaged mouse retinas. (PMID: 15325575) Chen L. … Dunaief J.L. (Exp. Eye Res. 2004) 23 67

Products for MT4 Gene

Sources for MT4 Gene

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