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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT3 Gene

protein-coding   GIFtS: 57
GCID: GC16P056623

metallothionein 3

(Previous name: metallothionein 3 (growth inhibitory factor (neurotrophic))...)
 Explore 40 diseases affiliated with
MT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MT3    

Aliases
for MT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metallothionein 31 2     MT-III2 3
GIF1 2 3     GRIF2
GIFB2 3 5     ZnMT32
Metallothionein 3 (Growth Inhibitory Factor (Neurotrophic))1 2     Metallothionein-31
Growth Inhibitory Factor2 3     Metallothionein-III3
MT-32 3     Metallothionein-III3

External Ids:    HGNC: 74081   Entrez Gene: 45042   Ensembl: ENSG000000872507   OMIM: 1392555   UniProtKB: P257133   

Export aliases for MT3 gene to outside databases

Previous GC identifers: GC16P047006 GC16P056674 GC16P056357 GC16P056398 GC16P055180 GC16P042492


Summaries
for MT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MT3_HUMAN, P25713
Function: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible
amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro

Gene Wiki entry for MT3


Genomic Views
for MT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT3 gene promoter:
         POU2F1   p53   AP-1   POU2F1a   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056623:  view genomic region     (about GC identifiers)

Start:
 56,622,986 bp from pter      End:
 56,625,000 bp from pter
Size:
 2,015 bases      Orientation:
 plus strand

Proteins
for MT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MT3_HUMAN, P25713 (See protein sequence)
Recommended Name: Metallothionein-3  
Size: 68 amino acids; 6927 Da
3 PDB 3D structures from and Proteopedia for MT3:
2F5H (3D)        2FJ4 (3D)        2FJ5 (3D)    
Secondary accessions: Q2V574

Explore the universe of human proteins at neXtProt for MT3: NX_P25713

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25713

    • MT3 Protein expression data from MOPED and PaxDb:    About this image 
    MT3 Protein Expression
    REFSEQ proteins: NP_005945.1  
    ENSEMBL proteins: 
     ENSP00000455353   ENSP00000455980   ENSP00000200691   ENSP00000457164  

    Human Recombinant Protein Products for MT3: 
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    OriGene Custom Protein Services for MT3 
    GenScript Custom Purified and Recombinant Proteins Services for MT3
    Novus Biologicals MT3 Protein
    Novus Biologicals MT3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MT3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA10355541
    GO:0008021synaptic vesicle ISS--
    GO:0016234inclusion body IDA--
    GO:0048471perinuclear region of cytoplasm IDA--

    MT3 for ontologies           About GeneDecksing



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    Assay Products for MT3: 
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    Uscn ELISAs and CLIAs for MT3

    Protein Domains /
    Families
    for MT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MT3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P25713

    ProtoNet protein and cluster: P25713

    UniProtKB/Swiss-Prot: MT3_HUMAN, P25713
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Function
    for MT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT3_HUMAN, P25713
    Function: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible
    amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro

         Genatlas biochemistry entry for MT3:
    metallothionein 3,expressed in brain,growth inhibitory factor,neurotrophic

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding TAS8751715
    GO:0005515protein binding IPI--
    GO:0008144drug binding IDA19536566
    GO:0008270zinc ion binding IDA17712581
    GO:0016209antioxidant activity NAS12383939
         
    MT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MT3:
     Increased circadian rhythm amp 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mt3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    MT3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Mt3tm1Rpa for MT3
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MT3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MT3:
    hsa-miR-3202 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmid: MT3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT3 (see all 7)
    OriGene shRNA RFP: MT3
    OriGene siRNA: MT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT3
    Sirion Biotech Custom design and validation of potent shRNA sequences against MT3 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MT3 
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    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT3 (see all 3)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MT3 (NM_153759)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT3 

    Cell Line
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    Search LifeMap BioReagents cell lines for MT3
    Sirion Biotech Customized stable knockdown cell line services for MT3 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT3


    Pathways & Interactions
    for MT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MT3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MT3 (P257132, 3 ENSP000002006914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TTRP027662, 3, ENSP000002370144MINT-7905914 MINT-7905857 MINT-7905838 I2D: score=1 STRING: ENSP00000237014
    TERF2IPENSP000003000864STRING: ENSP00000300086
    About this table

    Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA18554677
    GO:0001666response to hypoxia IDA12763630
    GO:0001934positive regulation of protein phosphorylation IDA18295594
    GO:0006112energy reserve metabolic process ISS--
    GO:0006707cholesterol catabolic process ISS--

    MT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT3

    1 HMDB Compound for MT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    10/22 Novoseek chemical compound relationships for MT3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dtnb 63.1 4 7718580 (1), 19306065 (1), 16601975 (1)
    zinc 56 21 12220637 (2), 16087360 (2), 18208603 (1), 16308482 (1) (see all 11)
    cadmium 55.2 14 15461142 (2), 11521835 (2), 16087360 (2), 12220637 (1) (see all 7)
    cysteine 34 9 17389590 (1), 8412560 (1), 17532049 (1), 15982745 (1)
    threonine 13.5 1 9553716 (1)
    oxygen 5.88 12 12058024 (3), 11750760 (2), 12383939 (1), 10640628 (1) (see all 6)
    glyceraldehyde 3-phosphate 4.21 1 9437661 (1)
    melatonin 0 5 10913150 (3), 7853141 (1)
    endotoxin 0 1 1631128 (1)
    polyacrylamide 0 1 15982745 (1)

    Search CenterWatch for drugs/clinical trials and news about MT3 

    Transcripts
    for MT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MT3 gene: 
    NM_005954.2  

    Unigene Cluster for MT3:

    Metallothionein 3
    Hs.73133  [show with all ESTs]
    Unigene Representative Sequence: BM544485
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561640 ENST00000565838 ENST00000200691(uc002ejf.3) ENST00000566451(uc002ejg.3)
    ENST00000570176 ENST00000566576

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MT3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MT3:
    hsa-miR-3202 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmid: MT3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT3 (see all 7)
    OriGene shRNA RFP: MT3
    OriGene siRNA: MT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT3
    Sirion Biotech Custom design and validation of potent shRNA sequences against MT3 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT3 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MT3 (NM_153759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT3

    Additional cDNA sequence: 

    BC013081.1 BT007030.1 D13365.1 X89604.1 

    12 DOTS entries:

    DT.91763757  DT.453269  DT.120684919  DT.102843307  DT.120684846  DT.120684858  DT.91763750  DT.95135775 
    DT.120684967  DT.120684988  DT.120684956  DT.95207427 

    24/231 AceView cDNA sequences (see all 231):

    AW026555 AJ713317 BQ181970 F28406 AW043998 CB155600 AA323224 BX356856 
    AW118531 BU179032 F27839 BM766726 AW474901 AA343368 BQ772005 AI581831 
    AV727158 CR595825 BM888358 BQ050782 BQ640055 F30198 NM_005954 F28873 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MT3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
    SP1:        -                 -                     
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for MT3

    Expression
    for MT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACAGCAAAA
    MT3 Expression
    About this image

    MT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (Generation of mesend...)

    See MT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT3

    SOURCE GeneReport for Unigene cluster: Hs.73133

    UniProtKB/Swiss-Prot: MT3_HUMAN, P25713
    Tissue specificity: Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer
    disease (AD) brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including MT3: 
              Neurotrophins & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT3

    Orthologs
    for MT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MT3 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MT31 metallothionein 3 72.49(n)
    69.84(a)    		   770592  NM_001097538.1  NP_001091007.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MT36
    		 --
    		 65(a)
    		 1 → many
    		 GL343675.1(182526-186438)
    zebrafish
    (Danio rerio)    		 Actinopterygii mt26
    		 metallothionein 2
    		 62(a)
    		 1 → many
    		 18(17193795-17195147)


    ENSEMBL Gene Tree for MT3 (if available)
    TreeFam Gene Tree for MT3 (if available) 

    Paralogs
    for MT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT3 gene
    MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT2A2  MT42  MT1M2  
    MT1H2  MT1A2  
    6 SIMAP similar genes for MT3 using alignment to 4 protein entries:     MT3_HUMAN (see all proteins):
    MT1J    MT1E    MT1F    MT2A    MT1X    MT4

    MT3 for paralogs           About GeneDecksing



    Genomic Variants
    for MT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/83 NCBI SNPs in MT3 are shown (see all 83)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1420956341,2
    		--56621360(+) CAGCTA/GCTCTC 1 -- us2k10--------
    rs129223081,2
    		C,F--56621367(+) TCTCGC/TCCTGC 1 -- us2k113Minor allele frequency- T:0.40NA NS WA EA 558
    rs455933381,2
    		C,F--56621566(+) CTCACT/CGCAGC 1 -- us2k16Minor allele frequency- C:0.04NS EA 304
    rs454968941,2
    		C--56621586(+) CTGGGC/TTCAAG 1 -- us2k15Minor allele frequency- T:0.00NS 184
    rs456158351,2
    		C,F--56621606(+) CACCCT/CGGCCT 1 -- us2k18Minor allele frequency- C:0.10NS NA CSA EA 308
    rs1857826441,2
    		--56621625(+) GCTAGA/GGGTAC 1 -- us2k10--------
    rs1902078891,2
    		--56621715(+) GTTGCC/TTAGGC 1 -- us2k10--------
    rs1391703411,2
    		--56621829(+) TCCACA/GTACCC 1 -- us2k10--------
    rs454989911,2
    		C,F--56622105(+) TCAGTC/TACAAA 1 -- us2k110Minor allele frequency- T:0.09NS NA WA EA 550
    rs47846881,2
    		C,F,H--56622142(+) TTTTCC/TTTTCA 1 -- us2k1 trp317Minor allele frequency- T:0.08NS EA NA 1960

    HapMap Linkage Disequilibrium report for MT3 (56622986 - 56625000 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT3: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MT3 for disorders           About GeneDecksing

    OMIM gene information: 139255    OMIM disorders: --

    20/40 diseases for MT3 (see all 40):    About MalaCards
    serous cystadenoma    amyotrophic lateral sclerosis    pancreatic serous cystadenoma    placental abruption
    lateral sclerosis    cystadenoma    pituitary adenoma    multiple system atrophy
    pancreatic ductal adenocarcinoma    brain injury    chorioretinitis    down syndrome
    neurodegenerative disease    prion disease    intrahepatic cholangiocarcinoma    brain disease
    malignant glioma    parkinson's disease    renal cell carcinoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for MT3:
    Alzheimer's disease

    10/29 Novoseek disease relationships for MT3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 54.3 45 7834016 (2), 1873033 (2), 9437661 (2), 11245813 (2) (see all 28)
    brain diseases 44.4 6 7834016 (1), 7718580 (1), 1873033 (1), 12058024 (1) (see all 5)
    amyotrophic lateral sclerosis 39.9 1 7834016 (1)
    neurodegenerative diseases 34.2 6 9593981 (1), 11246971 (1), 10640628 (1)
    prostatic intraepithelial neoplasia 25.7 1 10517878 (1)
    breast cancer 21.5 10 12908821 (3), 2285593 (2), 16854967 (1), 10887492 (1) (see all 6)
    senile plaques 15.4 5 9367293 (3)
    prostate cancer 13.8 6 10517878 (3), 16854967 (1), 14672704 (1), 12908821 (1)
    neurological disorders 11.9 3 17018872 (2)
    creutzfeldt-jakob disease 10.7 1 7834016 (1)

    Genetic Association Database (GAD): MT3
    Human Genome Epidemiology (HuGE) Navigator: MT3 (3 documents)

    Export disorders for MT3 gene to outside databases

    Publications
    for MT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT3 gene, integrated from 9 sources (see all 188):
    (articles sorted by number of sources associating them with MT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MT-III, a brain-specific member of the metallothionein gene family. (PubMed id 1631128)1, 2, 3, 9 Palmiter R.D.... Durnam D.M. (1992)
    2. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. (PubMed id 1464312)1, 2, 9 Tsuji S.... Miyatake T. (1992)
    3. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. (PubMed id 1873033)1, 2, 9 Uchida Y.... Tomonaga M. (1991)
    4. Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes. (PubMed id 7677777)1, 2, 9 Amoureux M.C.... Pauwels P.J. (1995)
    5. Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis. (PubMed id 16036436)1, 4, 9 Morahan J.M....Pamphlett R. (2005)
    6. Structures of the human and mouse growth inhibitory factor-encoding genes. (PubMed id 8039715)1, 2, 9 Naruse S....Tsuji S. (1994)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Metallothionein isoform 3 and proximal tubule vectorial active transport. (PubMed id 11849386)1, 9 Kim D....Sens D.A. (2002)
    9. Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines. (PubMed id 10517878)1, 9 Garrett S.H....Sens D.A. (1999)
    10. Expression of metallothionein isoform 3 (MT-3) determines the choice between apoptotic or necrotic cell death in Cd+2-exposed human proximal tubule cells. (PubMed id 15129022)1, 9 Somji S....Sens D.A. (2004)

    External Searches for MT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4504 HGNC: 7408 AceView: MT2_ Ensembl:ENSG00000087250 euGenes: HUgn4504
    ECgene: MT3 H-InvDB: MT3

    Other Databases showing MT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mt3/

    Intellectual Property
    for MT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MT3 gene:
    Search GeneIP for patents involving MT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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