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MT3 Gene

protein-coding   GIFtS: 57
GCID: GC16P056623

Metallothionein 3

(Previous name: metallothionein 3 (growth inhibitory factor (neurotrophic)))
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Metallothionein 31 2     MT-III2 3
GIFB2 3 5     GRIF2
Metallothionein 3 (Growth Inhibitory Factor (Neurotrophic))1 2     ZnMT32
Growth Inhibitory Factor2 3     metallothionein-32
GIF2 3     metallothionein-III2
MT-32 3     Metallothionein-III3

External Ids:    HGNC: 74081   Entrez Gene: 45042   Ensembl: ENSG000000872507   OMIM: 1392555   UniProtKB: P257133   
ORGUL members:         

Export aliases for MT3 gene to outside databases

Previous GC identifers: GC16P047006 GC16P056674 GC16P056357 GC16P056398 GC16P055180 GC16P042492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT3 Gene:
MT3 (metallothionein 3) is a protein-coding gene. Diseases associated with MT3 include pancreatic serous cystadenoma, and placental abruption. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process and copper ion binding.

UniProtKB/Swiss-Prot: MT3_HUMAN, P25713
Function: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a
negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro

Gene Wiki entry for MT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT3 gene promoter:
         POU2F1   p53   AP-1   POU2F1a   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT3 promoter sequence
   Search Chromatin IP Primers for MT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056623:  view genomic region     (about GC identifiers)

Start:
56,622,986 bp from pter      End:
56,625,000 bp from pter
Size:
2,015 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MT3_HUMAN, P25713 (See protein sequence)
Recommended Name: Metallothionein-3  
Size: 68 amino acids; 6927 Da
3 PDB 3D structures from and Proteopedia for MT3:
2F5H (3D)        2FJ4 (3D)        2FJ5 (3D)    
Secondary accessions: Q2V574

Explore the universe of human proteins at neXtProt for MT3: NX_P25713

Explore proteomics data for MT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005945.1  
    ENSEMBL proteins: 
     ENSP00000455353   ENSP00000455980   ENSP00000200691   ENSP00000457164  

    MT3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MT3
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MT3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MT3
    GenScript Custom Purified and Recombinant Proteins Services for MT3
    Novus Biologicals MT3 Protein
    Novus Biologicals MT3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MT3

    MT3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MT3
    Novus Biologicals MT3 Antibodies
    Abcam antibodies for MT3
    Cloud-Clone Corp. Antibodies for MT3
    Search ThermoFisher Antibodies for MT3
    LSBio Antibodies in human, mouse, rat for MT3

    MT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MT3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MT3
    Cloud-Clone Corp. CLIAs for MT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P25713

    ProtoNet protein and cluster: P25713

    UniProtKB/Swiss-Prot: MT3_HUMAN, P25713
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    MT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT3_HUMAN, P25713
    Function: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a
    negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro

         Genatlas biochemistry entry for MT3:
    metallothionein 3,expressed in brain,growth inhibitory factor,neurotrophic

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding TAS8751715
    GO:0005515protein binding IPI--
    GO:0008144drug binding IDA19536566
    GO:0008270zinc ion binding IDA17712581
    GO:0016209antioxidant activity NAS12383939
         
    MT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MT3:
     Increased circadian rhythm amp 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mt3):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    MT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mt3tm1Rpa for MT3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MT3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MT3:
    hsa-miR-3202 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidMT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MT3
    Predesigned siRNA for gene silencing in human, mouse, rat MT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MT3

    Clone
    Products:
         
    OriGene clones in human, mouse for MT3 (see all 7)
    OriGene ORF clones in mouse, rat for MT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MT3 (NM_153759)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA10355541
    GO:0008021synaptic vesicle ISS--
    GO:0016234inclusion body IDA--
    GO:0048471perinuclear region of cytoplasm IDA--

    MT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including MT3: 
              Neurotrophins & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MT3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MT3 (P257131, 2, 3 ENSP000002006914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TTRP027661, 2, 3, ENSP000002370144EBI-8084264,EBI-711909 MINT-7905914 MINT-7905857 MINT-7905838 I2D: score=1 STRING: ENSP00000237014
    TERF2IPENSP000003000864STRING: ENSP00000300086
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IDA18554677
    GO:0001666response to hypoxia IDA12763630
    GO:0001934positive regulation of protein phosphorylation IDA18295594
    GO:0006112energy reserve metabolic process ISS--
    GO:0006707cholesterol catabolic process ISS--

    MT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT3

    1 HMDB Compound for MT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    Selected Novoseek inferred chemical compound relationships for MT3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dtnb 63.1 4 7718580 (1), 19306065 (1), 16601975 (1)
    zinc 56 21 12220637 (2), 16087360 (2), 18208603 (1), 16308482 (1) (see all 11)
    cadmium 55.2 14 15461142 (2), 11521835 (2), 16087360 (2), 12220637 (1) (see all 7)
    cysteine 34 9 17389590 (1), 8412560 (1), 17532049 (1), 15982745 (1)
    threonine 13.5 1 9553716 (1)
    oxygen 5.88 12 12058024 (3), 11750760 (2), 12383939 (1), 10640628 (1) (see all 6)
    glyceraldehyde 3-phosphate 4.21 1 9437661 (1)
    melatonin 0 5 10913150 (3), 7853141 (1)
    endotoxin 0 1 1631128 (1)
    polyacrylamide 0 1 15982745 (1)



    MT3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MT3 gene: 
    NM_005954.2  

    Unigene Cluster for MT3:

    Metallothionein 3
    Hs.73133  [show with all ESTs]
    Unigene Representative Sequence: BM544485
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561640 ENST00000565838 ENST00000200691(uc002ejf.3) ENST00000566451(uc002ejg.3)
    ENST00000570176 ENST00000566576

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MT3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MT3:
    hsa-miR-3202 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidMT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MT3
    Predesigned siRNA for gene silencing in human, mouse, rat MT3
    Clone
    Products:
         
    OriGene clones in human, mouse for MT3 (see all 7)
    OriGene ORF clones in mouse, rat for MT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MT3 (NM_153759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MT3
    OriGene qSTAR qPCR primer pairs in human, mouse for MT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MT3
      QuantiTect SYBR Green Assays in human, mouse, rat MT3
      QuantiFast Probe-based Assays in human, mouse, rat MT3

    Additional mRNA sequence: 

    BC013081.1 BT007030.1 D13365.1 X89604.1 

    12 DOTS entries:

    DT.91763757  DT.453269  DT.120684919  DT.102843307  DT.120684846  DT.120684858  DT.91763750  DT.95135775 
    DT.120684967  DT.120684988  DT.120684956  DT.95207427 

    Selected AceView cDNA sequences (see all 231):

    BQ430119 AJ573411 BM760525 BM887687 BX281399 BU164116 AI799708 AI206524 
    BQ182739 AA323224 F28406 CB851102 AU107621 BC013081 CB155600 BQ014486 
    AA343368 BQ082159 AJ709369 BQ225213 BQ772005 F28873 AV702264 CR595825 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MT3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
    SP1:        -                 -                     
    SP2:                          -                     
    SP3:                                                


    ECgene alternative splicing isoforms for MT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT3 expression in normal human tissues (normalized intensities)      MT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGCAAAA
    MT3 Expression
    About this image


    MT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
    MT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73133

    UniProtKB/Swiss-Prot: MT3_HUMAN, P25713
    Tissue specificity: Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the
    Alzheimer disease (AD) brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MT3: 
              Neurotrophins & Receptors in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MT3
    OriGene qSTAR qPCR primer pairs in human, mouse for MT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MT3
    QuantiTect SYBR Green Assays in human, mouse, rat MT3
    QuantiFast Probe-based Assays in human, mouse, rat MT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MT3 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mt35 metallothionein 3   --   8 (46.29 cM) 94152607 


    ENSEMBL Gene Tree for MT3 (if available)
    TreeFam Gene Tree for MT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MT3 gene
    6 SIMAP similar genes for MT3 using alignment to 4 protein entries:     MT3_HUMAN (see all proteins):
    MT1J    MT1E    MT1F    MT2A    MT1X    MT4

    MT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MT3 (see all 104)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420956341,2
    --56621360(+) CAGCTA/GCTCTC 1 -- us2k10--------
    rs129223081,2
    C,F--56621367(+) TCTCGC/TCCTGC 1 -- us2k113Minor allele frequency- T:0.40NA NS WA EA 558
    rs455933381,2
    C,F--56621566(+) CTCACT/CGCAGC 1 -- us2k16Minor allele frequency- C:0.04NS EA 304
    rs454968941,2
    C,F--56621586(+) CTGGGC/TTCAAG 1 -- us2k15Minor allele frequency- T:0.00NS 184
    rs456158351,2
    C,F--56621606(+) CACCCT/CGGCCT 1 -- us2k18Minor allele frequency- C:0.10NS NA CSA EA 308
    rs1857826441,2
    --56621625(+) GCTAGA/GGGTAC 1 -- us2k10--------
    rs1902078891,2
    --56621715(+) GTTGCC/TTAGGC 1 -- us2k10--------
    rs1391703411,2
    --56621829(+) TCCACA/GTACCC 1 -- us2k10--------
    rs454989911,2
    C,F--56622105(+) TCAGTC/TACAAA 1 -- us2k110Minor allele frequency- T:0.09NS NA WA EA 550
    rs47846881,2
    C,F,H--56622142(+) TTTTCC/TTTTCA 1 -- us2k1 trp317Minor allele frequency- T:0.08NS EA NA 1960

    HapMap Linkage Disequilibrium report for MT3 (56622986 - 56625000 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MT3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MT3
    DNA2.0 Custom Variant and Variant Library Synthesis for MT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139255    OMIM disorders: --

    Selected diseases for MT3 (see all 38):    About MalaCards
    pancreatic serous cystadenoma    placental abruption    brain disease    cystadenoma
    chorioretinitis    pancreatic ductal adenocarcinoma    prion disease    multiple system atrophy
    down syndrome    lateral sclerosis    pituitary adenoma    intrahepatic cholangiocarcinoma
    amyotrophic lateral sclerosis    esophageal cancer    cholangiocarcinoma    hypoxia
    peritonitis    dementia    parkinson's disease    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for MT3:
    Alzheimer's disease

    MT3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MT3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 54.3 45 7834016 (2), 1873033 (2), 9437661 (2), 11245813 (2) (see all 28)
    brain diseases 44.4 6 7834016 (1), 7718580 (1), 1873033 (1), 12058024 (1) (see all 5)
    amyotrophic lateral sclerosis 39.9 1 7834016 (1)
    neurodegenerative diseases 34.2 6 9593981 (1), 11246971 (1), 10640628 (1)
    prostatic intraepithelial neoplasia 25.7 1 10517878 (1)
    breast cancer 21.5 10 12908821 (3), 2285593 (2), 16854967 (1), 10887492 (1) (see all 6)
    senile plaques 15.4 5 9367293 (3)
    prostate cancer 13.8 6 10517878 (3), 16854967 (1), 14672704 (1), 12908821 (1)
    neurological disorders 11.9 3 17018872 (2)
    creutzfeldt-jakob disease 10.7 1 7834016 (1)

    Genetic Association Database (GAD): MT3
    Human Genome Epidemiology (HuGE) Navigator: MT3 (3 documents)

    Export disorders for MT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT3 gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with MT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MT-III, a brain-specific member of the metallothionein gene family. (PubMed id 1631128)1, 2, 3, 9 Palmiter R.D.... Durnam D.M. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. (PubMed id 1464312)1, 2, 9 Tsuji S.... Miyatake T. (EMBO J. 1992)
    3. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. (PubMed id 1873033)1, 2, 9 Uchida Y.... Tomonaga M. (Neuron 1991)
    4. Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes. (PubMed id 7677777)1, 2, 9 Amoureux M.C.... Pauwels P.J. (Biochem. Biophys. Res. Commun. 1995)
    5. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. (PubMed id 16546755)1, 4, 9 Hayashi Y....Hozumi I. (Amyotroph Lateral Scler 2006)
    6. Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis. (PubMed id 16036436)1, 4, 9 Morahan J.M....Pamphlett R. (Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2005)
    7. Structures of the human and mouse growth inhibitory factor-encoding genes. (PubMed id 8039715)1, 2, 9 Naruse S....Tsuji S. (Gene 1994)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Metallothionein isoform 3 and proximal tubule vectorial active transport. (PubMed id 11849386)1, 9 Kim D....Sens D.A. (Kidney Int. 2002)
    10. Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines. (PubMed id 10517878)1, 9 Garrett S.H....Sens D.A. (Prostate 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4504 HGNC: 7408 AceView: MT2_ Ensembl:ENSG00000087250 euGenes: HUgn4504
    ECgene: MT3 H-InvDB: MT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mt3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT3 gene:
    Search GeneIP for patents involving MT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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