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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT2A Gene

protein-coding   GIFtS: 62
GCID: GC16P056642

metallothionein 2A


(Previous symbol: MT2)
 Explore 50 diseases affiliated with
MT2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MT2A    

Aliases
for MT2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metallothionein 2A1 2     Metallothionein-2A3
MT21 2 3 5     Metallothionein-II3
MT-22 3     CES13
MT-II2 3     Metallothionein-2A3
Metallothionein-21     Metallothionein-II3

External Ids:    HGNC: 74061   Entrez Gene: 45022   Ensembl: ENSG000001251487   OMIM: 1563605   UniProtKB: P027953   

Export aliases for MT2A gene to outside databases

Previous GC identifers: GC16P047025 GC16P056693 GC16P056376 GC16P056417 GC16P055199 GC16P042512


Summaries
for MT2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT2A (Metallothionein 2A)


Genomic Views
for MT2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT2A gene promoter:
         GR   p53   AP-1   ATF-2   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MT2A promoter sequence
   Search SABiosciences Chromatin IP Primers for MT2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT2A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056642:  view genomic region     (about GC identifiers)

Start:
 56,642,111 bp from pter      End:
 56,643,409 bp from pter
Size:
 1,299 bases      Orientation:
 plus strand

Proteins
for MT2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MT2_HUMAN, P02795 (See protein sequence)
Recommended Name: Metallothionein-2  
Size: 61 amino acids; 6042 Da
Miscellaneous: This metallothionein binds zinc
2 PDB 3D structures from and Proteopedia for MT2A:
1MHU (3D)        2MHU (3D)    
Secondary accessions: Q14823 Q2HXR9 Q53XT9

Explore the universe of human proteins at neXtProt for MT2A: NX_P02795

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02795

    • MT2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005944.1  
    ENSEMBL proteins: 
     ENSP00000245185   ENSP00000456804  
    Reactome Protein details: P02795
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: MT2A
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    Novus Biologicals MT2A Protein
    Novus Biologicals MT2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MT2A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm ISS--


    MT2A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MT2A

    Protein Domains /
    Families
    for MT2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MT2A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P02795

    ProtoNet protein and cluster: P02795

    1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
    the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Function
    for MT2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
    transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT2A:
    metallothionein 2

    miRNA
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    hsa-mir-197 (MIRT004206)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT2A (see all 4)
    OriGene shRNA RFP: MT2A
    OriGene siRNA: MT2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT2A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MT2A

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MT2A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT2A

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15541360
    GO:0008144drug binding IDA19536566
    GO:0008270zinc ion binding ISS--
    GO:0046872metal ion binding ----


    MT2A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MT2A:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for MT2A: Mt2tm1Bri Mt2tm1Rch
         15/19 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mt2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  reproductive system 

    MT2A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MT2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Interferon gamma signaling
    		Interferon gamma signaling1.00
    		Expression of IFNG-stimulated genes0.72
    2Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    3Immune System
    		Immune System1.00
    4Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    		Platinum Pathway, Pharmacokinetics/Pharmacodynamics1.00
    5Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for MT2A
        Interferon gamma signaling
    Cytokine Signaling in Immune system
    Expression of IFNG-stimulated genes
    Interferon Signaling
    Immune System

    1 PharmGKB Pathway for MT2A
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    1         Kegg Pathway  (Kegg details for MT2A):
        Mineral absorption


    MT2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for MT2A (P027951, 2, 3 ENSP000002451854) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR50Q135852, 3, ENSP000002183164MINT-2836197 MINT-2836127 I2D: score=1 STRING: ENSP00000218316
    PRKD1Q151391, 3, ENSP000003335684EBI-996616,EBI-1181072 I2D: score=3 STRING: ENSP00000333568
    CXorf40AQ8TE691, 3EBI-996616,EBI-996609 I2D: score=2 
    SPINK7P580621, 3, ENSP000002745654EBI-996616,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    ADAMTS4O751733, ENSP000003569754I2D: score=1 STRING: ENSP00000356975
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006878cellular copper ion homeostasis TAS6719135
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035690cellular response to drug IDA19536566
    GO:0036016cellular response to interleukin-3 IEP11168427
    GO:0036018cellular response to erythropoietin IEP11168427


    MT2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MT2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT2A
    10/23 Novoseek chemical compound relationships for MT2A gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.3 29 19097988 (3), 17308060 (2), 16087360 (2), 12566070 (2) (see all 17)
    cadmium 66.6 23 16600086 (3), 18755257 (2), 17485079 (2), 16087360 (2) (see all 12)
    cdcl2 64 6 10403520 (2), 9545559 (2), 16402917 (1), 12566070 (1)
    copper 42 12 8552721 (5), 2066364 (2), 10471781 (1)
    arsenite 34.8 6 15725085 (3), 7999084 (2)
    n acetylcysteine 33.3 8 9545559 (2), 19097988 (1), 18586083 (1), 15725085 (1)
    silver nitrate 30.2 6 18586083 (4), 17308060 (1)
    cisplatin 27.1 6 10422815 (1)
    cysteine 23.8 1 16556599 (1)
    oligonucleotide 19.8 4 12173077 (1), 8134403 (1), 15583813 (1)

    Search CenterWatch for drugs/clinical trials and news about MT2A / MT2 

    Transcripts
    for MT2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MT2A gene: 
    NM_005953.3  

    Unigene Cluster for MT2A:

    Metallothionein 2A
    Hs.647371  [show with all ESTs]
    Unigene Representative Sequence: BF131637
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245185(uc002ejh.3) ENST00000563985 ENST00000562017 ENST00000561491
    ENST00000567300

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MT2A
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT2A (see all 4)
    OriGene shRNA RFP: MT2A
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT2A
    Clone
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    GenScript: all cDNA clones in your preferred vector: MT2A (NM_005953)
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    Primer
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    Additional cDNA sequence: 

    BC007034.1 BC062435.1 BC070289.1 BT007315.1 M26637.1 S52379.1 V00594.1 X97260.1 

    24/27 DOTS entries (see all 27):

    DT.100058622  DT.91888226  DT.100893285  DT.101985063  DT.85102758  DT.100059597  DT.419190  DT.121273946 
    DT.87013827  DT.91641761  DT.120684886  DT.100893311  DT.100685880  DT.100893315  DT.91705372  DT.120684782 
    DT.120684958  DT.95200190  DT.97862507  DT.120684992  DT.120685031  DT.95190527  DT.95190547  DT.120684982 

    24/231 AceView cDNA sequences (see all 231):

    CB118333 CR621046 BU179032 AU076535 AI418147 AI206524 AJ705828 BQ082159 
    BC035624 BU730105 AJ573772 BM888358 S68949 AA343368 AJ711526 AW055185 
    BG180522 BQ181442 NM_005954 AJ713317 BM817906 BM887687 BQ640055 F28873 

    GeneLoc Exon Structure


    Expression
    for MT2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATCCCAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MT2A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    OvaryPrimary FollicleGranulosa CellsOvary
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Mesendoderm-like cells (Generation of mesend...)
    Matrigel embedded cells (Derivation of cardio...)

    See MT2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT2A

    SOURCE GeneReport for Unigene cluster: Hs.647371
        SABiosciences Expression via Pathway-Focused PCR Array including MT2A: 
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT2A

    Orthologs
    for MT2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MT2A gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MT41 metallothionein 4 73.33(n)
    76.67(a)    		   396212  NM_205275.1  NP_990606.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MT36
    		 --
    		 71(a)
    		 1 → many
    		 GL343675.1(182526-186438)
    zebrafish
    (Danio rerio)    		 Actinopterygii mt26
    		 metallothionein 2
    		 63(a)
    		 1 → many
    		 18(17193795-17195147)


    ENSEMBL Gene Tree for MT2A (if available)
    TreeFam Gene Tree for MT2A (if available) 

    Paralogs
    for MT2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT2A gene
    MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT42  MT1M2  MT32  
    MT1H2  MT1A2  
    14 SIMAP similar genes for MT2A using alignment to 2 protein entries:     MT2_HUMAN (see all proteins):
    MT1A    MT1L    MT1H    MT1B    MTP    MT1J
    MTE    MT1G    MT1M    MT1F    MT3    MT1X
    MT4    MT1E

    MT2A for paralogs           About GeneDecksing



    Genomic Variants
    for MT2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/62 NCBI SNPs in MT2A are shown (see all 62)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1409668111,2
    		--56640478(+) GACCAC/TCTGAG 1 -- us2k10--------
    rs1827136911,2
    		--56640511(+) TATATA/GATACT 1 -- us2k10--------
    rs118655171,2
    		C,H,--56640675(+) gatgaA/Gtaaac 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs71965031,2
    		C,F,A,H,--56640739(+) AGTGGC/TCGAGT 1 -- us2k116Minor allele frequency- T:0.08NS EA NA WA CSA 968
    rs1854880981,2
    		--56640813(+) GTGAGA/CACGCA 1 -- us2k10--------
    rs1511581081,2
    		--56640967(+) TGGCCC/TGGTGC 1 -- us2k10--------
    rs802112711,2
    		--56641011(+) ATGACG/TGCCCT 1 -- us2k10--------
    rs790530101,2
    		--56641023(+) GGCATC/TTCCAG 1 -- us2k10--------
    rs348002571,2
    		C,F,--56641032(+) AGTGGT/CCAGGG 1 -- us2k17Minor allele frequency- C:0.05NS WA 308
    rs1464307571,2
    		--56641077(+) GTCCCC/TGCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MT2A (56642111 - 56643409 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT2A: --
    Human Gene Mutation Database (HGMD): MT2A

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MT2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MT2A for disorders           About GeneDecksing

    OMIM gene information: 156360    OMIM disorders: --

    20/50 diseases for MT2A (see all 50):    About MalaCards
    type 2 diabetes mellitus    xeroderma pigmentosum    amyotrophic lateral sclerosis    lateral sclerosis
    diabetes mellitus    menkes disease    acute lymphoblastic leukemia    chorioretinitis
    lymphoblastic leukemia    lupus nephritis    scrapie    cockayne syndrome
    nephritis    multiple myeloma    cerebral lymphoma    keloids
    hepatitis c    ovarian cancer    bladder carcinoma    nasopharyngitis

    10 Novoseek disease relationships for MT2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21.3 7 11756227 (2), 11291768 (2), 15188022 (1), 15788722 (1) (see all 5)
    nasopharyngeal carcinoma 19.8 1 15583813 (1)
    shock 15.4 4 8552721 (1), 12016146 (1), 15734587 (1), 19540330 (1)
    tumors 4.55 10 18755257 (2), 15188022 (1), 11756227 (1), 12646258 (1) (see all 7)
    prostate cancer 3.62 2 10754528 (1), 14550308 (1)
    cancer 3.52 2 11756227 (1), 18341518 (1)
    asthma 0 1 16427169 (1)
    inflammation 0 2 15541360 (1), 16215939 (1)
    ovarian cancer 0 2 11077043 (1)
    bladder cancer 0 4 11270423 (3)

    Human Genome Epidemiology (HuGE) Navigator: MT2A (15 documents)

    Export disorders for MT2A gene to outside databases

    Publications
    for MT2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT2A gene, integrated from 9 sources (see all 204):
    (articles sorted by number of sources associating them with MT2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PubMed id 7133118)1, 2, 3 Karin M. and Richards R.I. (1982)
    2. Expression of human metallothionein-II fusion protein in Escherichia coli. (PubMed id 1339282)1, 2, 9 Yamazaki S.... Kagawa Y. (1992)
    3. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PubMed id 2388267)1, 2, 9 Messerle B.A.... Wuethrich K. (1990)
    4. Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PubMed id 1593628)1, 2, 9 Messerle B.A.... Wuethrich K. (1992)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Changes in brain gene expression shared by scrapie and Alzheimer disease. (PubMed id 2780570)1, 2 Duguid J.R.... Tourtellotte W.W. (1989)
    7. Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. (PubMed id 6896577)1, 2 Karin M. and Richards R.I. (1982)
    8. Primary structure of human hepatic metallothionein. (PubMed id 913597)1, 2 Kissling M.M. and Kaegi J.H.R. (1977)
    9. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PubMed id 12646258)1, 9 Cui Y....Lu S.H. (2003)
    10. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. (PubMed id 16402917)1, 9 Reinecke F....Van der Westhuizen F.H. (2006)

    External Searches for MT2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MT2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4502 HGNC: 7406 AceView: MT2_ Ensembl:ENSG00000125148 euGenes: HUgn4502
    ECgene: MT2A Kegg: 4502 H-InvDB: MT2A

    Other Databases showing MT2A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MT2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT2A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mt2a/

    Intellectual Property
    for MT2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MT2A gene:
    Search GeneIP for patents involving MT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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