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Aliases for MT2A Gene

Subcategory (RNA class) for MT2A Gene

lncRNA

Aliases for MT2A Gene

  • Metallothionein 2A 2 3 5
  • Metallothionein-II 3 4
  • MT-II 3 4
  • MT-2 3 4
  • MT2 3 4
  • Metallothionein-2A 4
  • Metallothionein-2 3
  • CES1 4

External Ids for MT2A Gene

ORGUL Members for MT2A Gene

Previous HGNC Symbols for MT2A Gene

  • MT2

Previous GeneCards Identifiers for MT2A Gene

  • GC16P047025
  • GC16P056693
  • GC16P056376
  • GC16P056417
  • GC16P055199
  • GC16P056642
  • GC16P042512
  • GC16P056610
  • GC16P056611
  • GC16P056612
  • GC16P056613
  • GC16P056614

Summaries for MT2A Gene

GeneCards Summary for MT2A Gene

MT2A (Metallothionein 2A) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with MT2A include Inverted Papilloma and Scrapie. Among its related pathways are Copper homeostasis and Interferon gamma signaling. GO annotations related to this gene include drug binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot for MT2A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT2A Gene

fRNAdb sequence ontologies for MT2A Gene

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MT2A

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MT2A Gene

Genomics for MT2A Gene

Regulatory Elements for MT2A Gene

Enhancers for MT2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G056604 2 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +2.0 1957 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 BBS2 MT1A MT1F MT1G MT1H MT3 MT1DP MT1CP MT1B POLR2C
GH16G056603 1.4 Ensembl ENCODE dbSUPER 0.7 -4.3 -4336 0.5 ELF3 PKNOX1 ARID4B ZSCAN9 RAD21 RARA ZNF121 ZNF143 MIXL1 ZNF263 MT1G MT1H MT1B MT1X MT1A MT2A MT3
GH16G056605 0.9 ENCODE dbSUPER 0.7 -3.8 -3818 0.1 ZNF263 RNF2 SUZ12 NRF1 CBX2 YY1 NR2F2 ZNF121 GABPB1 RXRB MT1G MT1H MT1B MT1X MT1A MT2A MT3
GH16G056600 1 ENCODE dbSUPER 0.4 -7.6 -7616 0.2 CTCF PKNOX1 TEAD1 SUZ12 CEBPB CBX2 CEBPG REST RAD21 TEAD3 MT2A MT3
GH16G056589 0.8 Ensembl dbSUPER 0.4 -18.7 -18699 0.6 MXI1 HDAC2 SUZ12 CBX2 RBBP5 EP300 EZH2 MT1E MT3 MT2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MT2A on UCSC Golden Path with GeneCards custom track

Promoters for MT2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086294 1001 1601 HNRNPUL1 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for MT2A Gene

Chromosome:
16
Start:
56,608,199 bp from pter
End:
56,609,497 bp from pter
Size:
1,299 bases
Orientation:
Plus strand

Genomic View for MT2A Gene

Genes around MT2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT2A Gene

ORGUL Member Location for MT2A Gene

ORGUL Member Location for MT2A gene

Proteins for MT2A Gene

  • Protein details for MT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02795-MT2_HUMAN
    Recommended name:
    Metallothionein-2
    Protein Accession:
    P02795
    Secondary Accessions:
    • Q14823
    • Q2HXR9
    • Q53XT9

    Protein attributes for MT2A Gene

    Size:
    61 amino acids
    Molecular mass:
    6042 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This metallothionein binds zinc.

    Three dimensional structures from OCA and Proteopedia for MT2A Gene

neXtProt entry for MT2A Gene

Post-translational modifications for MT2A Gene

  • Ubiquitination at posLast=5151
  • Modification sites at PhosphoSitePlus

Other Protein References for MT2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT2A Gene

Domains & Families for MT2A Gene

Gene Families for MT2A Gene

Suggested Antigen Peptide Sequences for MT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02795

UniProtKB/Swiss-Prot:

MT2_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT2A: view

Function for MT2A Gene

Molecular function for MT2A Gene

GENATLAS Biochemistry:
metallothionein 2
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008144 drug binding IDA 19536566
GO:0008270 zinc ion binding ISS --
GO:0046870 cadmium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT2A: view
genes like me logo Genes that share phenotypes with MT2A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MT2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT2A Gene

Localization for MT2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT2A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT2A Gene

Pathways & Interactions for MT2A Gene

genes like me logo Genes that share pathways with MT2A: view

Pathways by source for MT2A Gene

Gene Ontology (GO) - Biological Process for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006878 cellular copper ion homeostasis TAS 6719135
GO:0006882 cellular zinc ion homeostasis IEA --
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0010038 response to metal ion TAS --
GO:0010273 detoxification of copper ion IEA --
genes like me logo Genes that share ontologies with MT2A: view

No data available for SIGNOR curated interactions for MT2A Gene

Drugs & Compounds for MT2A Gene

(18) Drugs for MT2A Gene - From: DrugBank, ApexBio, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 2050
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1460
Agomelatine Approved, Investigational Pharma Antagonist MT1/MT2 / 5-HT2C agonist 0
Eloxatin Approved August 2002 Pharma 0

(9) Additional Compounds for MT2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MT2A Gene

Compound Action Cas Number
Agomelatine MT1/MT2 / 5-HT2C agonist 138112-76-2
genes like me logo Genes that share compounds with MT2A: view

Drug Products

Transcripts for MT2A Gene

fRNAdb Secondary structures for MT2A Gene

  • FR000455

Unigene Clusters for MT2A Gene

Metallothionein 2A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MT2A

Alternative Splicing Database (ASD) splice patterns (SP) for MT2A Gene

No ASD Table

Relevant External Links for MT2A Gene

GeneLoc Exon Structure for
MT2A
ECgene alternative splicing isoforms for
MT2A

Expression for MT2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT2A Gene

mRNA differential expression in normal tissues according to GTEx for MT2A Gene

This gene is overexpressed in Liver (x9.4).

Protein differential expression in normal tissues from HIPED for MT2A Gene

This gene is overexpressed in Fetal Liver (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MT2A Gene



Protein tissue co-expression partners for MT2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MT2A Gene:

MT2A

SOURCE GeneReport for Unigene cluster for MT2A Gene:

Hs.534330

Evidence on tissue expression from TISSUES for MT2A Gene

  • Liver(4.9)
  • Kidney(4.7)
  • Nervous system(4.7)
  • Stomach(3.4)
  • Muscle(2.9)
  • Heart(2.8)
  • Intestine(2.7)
  • Lung(2.5)
  • Adrenal gland(2.4)
  • Eye(2.1)
  • Spleen(2.1)
  • Gall bladder(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with MT2A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT2A Gene

Orthologs for MT2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT2A 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia MT2A 35
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MT2 35
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mt1 35
  • 82 (a)
ManyToMany
Species where no ortholog for MT2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT2A Gene

ENSEMBL:
Gene Tree for MT2A (if available)
TreeFam:
Gene Tree for MT2A (if available)

Paralogs for MT2A Gene

Paralogs for MT2A Gene

(14) SIMAP similar genes for MT2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MT2A: view

Variants for MT2A Gene

Sequence variations from dbSNP and Humsavar for MT2A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001822139 -- 56,607,503(+) AGCGC(C/T)AGACA upstream-variant-2KB
rs1001938051 -- 56,607,688(+) TCCTT(C/G)CCACT upstream-variant-2KB
rs1006449317 -- 56,607,412(+) AGCCT(G/T)CCAGG upstream-variant-2KB
rs1007722906 -- 56,608,524(+) GGCGG(A/G)GCTTT upstream-variant-2KB
rs1007750167 -- 56,608,335(+) CCTCC(C/T)GCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT2A Gene

Variant ID Type Subtype PubMed ID
esv2714516 CNV deletion 23290073

Variation tolerance for MT2A Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT2A Gene

Human Gene Mutation Database (HGMD)
MT2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT2A Gene

Disorders for MT2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for MT2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inverted papilloma
  • inverted papilloma, squamous cell
scrapie
- elite association - COSMIC cancer census association via MalaCards
Search MT2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for MT2A

Genetic Association Database (GAD)
MT2A
Human Genome Epidemiology (HuGE) Navigator
MT2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT2A
genes like me logo Genes that share disorders with MT2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT2A Gene

Publications for MT2A Gene

  1. The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population. (PMID: 19572214) Kayaalti Z. … SAPylemezoA9lu T. (Mol. Biol. Rep. 2010) 3 22 46 64
  2. Expression of human metallothionein-II fusion protein in Escherichia coli. (PMID: 1339282) Yamazaki S. … Kagawa Y. (Biochem. Int. 1992) 3 4 22 64
  3. Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PMID: 1593628) Messerle B.A. … Wuethrich K. (J. Mol. Biol. 1992) 3 4 22 64
  4. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PMID: 2388267) Messerle B.A. … Wuethrich K. (J. Mol. Biol. 1990) 3 4 22 64
  5. Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PMID: 7133118) Karin M. … Richards R.I. (Nature 1982) 2 3 4 64

Products for MT2A Gene

  • Addgene plasmids for MT2A

Sources for MT2A Gene

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