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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT2A Gene

protein-coding   GIFtS: 63
GCID: GC16P056642

Metallothionein 2A


(Previous symbol: MT2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Metallothionein 2A1 2     metallothionein-2A2
MT21 2 3 5     metallothionein-II2
MT-22 3     CES13
MT-II2 3     Metallothionein-2A3
metallothionein-22     Metallothionein-II3

External Ids:    HGNC: 74061   Entrez Gene: 45022   Ensembl: ENSG000001251487   OMIM: 1563605   UniProtKB: P027953   

Export aliases for MT2A gene to outside databases

Previous GC identifers: GC16P047025 GC16P056693 GC16P056376 GC16P056417 GC16P055199 GC16P042512


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MT2A Gene: 
MT2A (metallothionein 2A) is a protein-coding gene. Diseases associated with MT2A include cerebral lymphoma, and scrapie, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include drug binding and zinc ion binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT2A (Metallothionein 2A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT2A gene promoter:
         GR   p53   AP-1   ATF-2   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MT2A promoter sequence
   Search SABiosciences Chromatin IP Primers for MT2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT2A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056642:  view genomic region     (about GC identifiers)

Start:
56,642,111 bp from pter      End:
56,643,409 bp from pter
Size:
1,299 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795 (See protein sequence)
Recommended Name: Metallothionein-2  
Size: 61 amino acids; 6042 Da
Miscellaneous: This metallothionein binds zinc
2 PDB 3D structures from and Proteopedia for MT2A:
1MHU (3D)        2MHU (3D)    
Secondary accessions: Q14823 Q2HXR9 Q53XT9

Explore the universe of human proteins at neXtProt for MT2A: NX_P02795

Explore proteomics data for MT2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02795

  • MT2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MT2A Protein Expression
    REFSEQ proteins: NP_005944.1  
    ENSEMBL proteins: 
     ENSP00000245185   ENSP00000456804  
    Reactome Protein details: P02795
    Human Recombinant Protein Products for MT2A: 
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    OriGene Purified Protein for MT2A
    OriGene Protein Over-expression Lysate for MT2A
    OriGene MassSpec for MT2A 
    OriGene Custom Protein Services for MT2A
    GenScript Custom Purified and Recombinant Proteins Services for MT2A
    Novus Biologicals MT2A Protein
    Novus Biologicals MT2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm ISS--

    MT2A for ontologies           About GeneDecksing



    MT2A Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P02795

    ProtoNet protein and cluster: P02795

    1 Blocks protein domain: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    MT2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT2_HUMAN, P02795
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT2A:
    metallothionein 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12646258
    GO:0008144drug binding IDA19536566
    GO:0008270zinc ion binding ISS--
    GO:0046872metal ion binding ----
         
    MT2A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MT2A:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

         15/19 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mt2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  reproductive system 

    MT2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MT2A: Mt2tm1Bri Mt2tm1Rch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MT2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MT2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT2A 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MT2A:
    hsa-mir-197 (MIRT004206)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT2A
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                         Customized lentivirus expression plasmids for stable overexpression of MT2A 

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    Search LifeMap BioReagents cell lines for MT2A
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MT2A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    3Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    4Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for MT2A
        Interferon gamma signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System

    1 PharmGKB Pathway for MT2A
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    1         Kegg Pathway  (Kegg details for MT2A):
        Mineral absorption


    MT2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for MT2A (P027951, 2, 3 ENSP000002451854) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR50Q135852, 3, ENSP000002183164MINT-2836197 MINT-2836127 I2D: score=1 STRING: ENSP00000218316
    PRKD1Q151391, 3, ENSP000003335684EBI-996616,EBI-1181072 I2D: score=3 STRING: ENSP00000333568
    CXorf40AQ8TE691, 3EBI-996616,EBI-996609 I2D: score=2 
    SPINK7P580621, 3, ENSP000002745654EBI-996616,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    ADAMTS4O751733, ENSP000003569754I2D: score=1 STRING: ENSP00000356975
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006878cellular copper ion homeostasis TAS6719135
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035690cellular response to drug IDA19536566
    GO:0036016cellular response to interleukin-3 IEP11168427
    GO:0036018cellular response to erythropoietin IEP11168427

    MT2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT2A (MT2)

    10/23 Novoseek inferred chemical compound relationships for MT2A gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.3 29 19097988 (3), 17308060 (2), 16087360 (2), 12566070 (2) (see all 17)
    cadmium 66.6 23 16600086 (3), 18755257 (2), 17485079 (2), 16087360 (2) (see all 12)
    cdcl2 64 6 10403520 (2), 9545559 (2), 16402917 (1), 12566070 (1)
    copper 42 12 8552721 (5), 2066364 (2), 10471781 (1)
    arsenite 34.8 6 15725085 (3), 7999084 (2)
    n acetylcysteine 33.3 8 9545559 (2), 19097988 (1), 18586083 (1), 15725085 (1)
    silver nitrate 30.2 6 18586083 (4), 17308060 (1)
    cisplatin 27.1 6 10422815 (1)
    cysteine 23.8 1 16556599 (1)
    oligonucleotide 19.8 4 12173077 (1), 8134403 (1), 15583813 (1)

    Search CenterWatch for drugs/clinical trials and news about MT2A / MT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MT2A gene: 
    NM_005953.3  

    Unigene Cluster for MT2A:

    Metallothionein 2A
    Hs.534330  [show with all ESTs]
    Unigene Representative Sequence: BF131637
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245185(uc002ejh.3) ENST00000563985 ENST00000562017 ENST00000561491
    ENST00000567300

    miRNA
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    Products:
         
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT2A
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                         Customized lentivirus expression plasmids for stable overexpression of MT2A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT2A

    Additional mRNA sequence: 

    BC007034.1 BC062435.1 BC070289.1 BT007315.1 M26637.1 S52379.1 V00594.1 X97260.1 

    24/35 DOTS entries (see all 35):

    DT.100058622  DT.91888226  DT.100893285  DT.101985063  DT.85102758  DT.100059597  DT.419190  DT.121273946 
    DT.87013827  DT.91641761  DT.120684886  DT.100893311  DT.100685880  DT.100893315  DT.218152  DT.101982092 
    DT.91705372  DT.120684782  DT.120684829  DT.120684958  DT.219307  DT.95200190  DT.97862507  DT.100800149 

    24/231 AceView cDNA sequences (see all 231):

    BQ433067 AW275159 AJ709369 BX396503 N71292 AW118531 CB155600 F28406 
    AV702264 BQ772005 AW055185 AJ713317 AA374803 BQ014486 AI459690 CB851102 
    BQ225213 AJ711526 BQ181970 AV727158 BM766726 BQ430119 BM547245 AI129861 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT2A expression in normal human tissues (normalized intensities)      MT2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCCAACT
    MT2A Expression
    About this image


    MT2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer

    See MT2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT2A

    SOURCE GeneReport for Unigene cluster: Hs.534330
        SABiosciences Expression via Pathway-Focused PCR Array including MT2A: 
              Drug Metabolism in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MT2A
    OriGene qSTAR qPCR primer pairs in human, mouse for MT2A
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MT2A gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mt25 metallothionein 2   --   8 (46.32 cM) 94172618 
    chicken
    (Gallus gallus)
    Aves MT41 metallothionein 4 73.33(n)
    76.67(a)
      396212  NM_205275.1  NP_990606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mt26
    metallothionein 2
    60(a)
    1 → many
    18(17193795-17195147)


    ENSEMBL Gene Tree for MT2A (if available)
    TreeFam Gene Tree for MT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT2A gene
    MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT1HL12  MT1M2  MT1H2  
    MT1A2  
    15 SIMAP similar genes for MT2A using alignment to 2 protein entries:     MT2_HUMAN (see all proteins):
    MT1A    MT1L    MT1H    MT1B    MT1HL1    MTP
    MT1J    MTE    MT1G    MT1M    MT1F    MT3
    MT1X    MT4    MT1E

    MT2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/70 SNPs in MT2A are shown (see all 70)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409668111,2
    C--56640478(+) GACCAC/TCTGAG 1 -- us2k10--------
    rs1827136911,2
    --56640511(+) TATATA/GATACT 1 -- us2k10--------
    rs118655171,2
    C,F,H--56640675(+) gatgaA/Gtaaac 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs71965031,2
    C,F,A,H--56640739(+) AGTGGC/TCGAGT 1 -- us2k116Minor allele frequency- T:0.08NS EA NA WA CSA 968
    rs1854880981,2
    --56640813(+) GTGAGA/CACGCA 1 -- us2k10--------
    rs1511581081,2
    --56640967(+) TGGCCC/TGGTGC 1 -- us2k10--------
    rs802112711,2
    F--56641011(+) ATGACG/TGCCCT 1 -- us2k10--------
    rs790530101,2
    F--56641023(+) GGCATC/TTCCAG 1 -- us2k10--------
    rs348002571,2
    C,F--56641032(+) AGTGGT/CCAGGG 1 -- us2k17Minor allele frequency- C:0.05NS WA 308
    rs1464307571,2
    --56641077(+) GTCCCC/TGCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MT2A (56642111 - 56643409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MT2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714516CNV Deletion23290073
    nsv906720CNV Loss21882294


    Human Gene Mutation Database (HGMD): MT2A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MT2A
    DNA2.0 Custom Variant and Variant Library Synthesis for MT2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 156360    OMIM disorders: --

    20/44 diseases for MT2A (see all 44):    About MalaCards
    cerebral lymphoma    scrapie    menkes disease    chorioretinitis
    nasopharyngitis    keloids    lupus nephritis    xeroderma pigmentosum
    nephritis    esophageal cancer    bladder carcinoma    thyroid cancer
    sarcoidosis    esophagitis    multiple myeloma    acute lymphoblastic leukemia
    amyotrophic lateral sclerosis    lateral sclerosis    graves' disease    lymphoblastic leukemia


    MT2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for MT2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21.3 7 11756227 (2), 11291768 (2), 15188022 (1), 15788722 (1) (see all 5)
    nasopharyngeal carcinoma 19.8 1 15583813 (1)
    shock 15.4 4 8552721 (1), 12016146 (1), 15734587 (1), 19540330 (1)
    tumors 4.55 10 18755257 (2), 15188022 (1), 11756227 (1), 12646258 (1) (see all 7)
    prostate cancer 3.62 2 10754528 (1), 14550308 (1)
    cancer 3.52 2 11756227 (1), 18341518 (1)
    asthma 0 1 16427169 (1)
    inflammation 0 2 15541360 (1), 16215939 (1)
    ovarian cancer 0 2 11077043 (1)
    bladder cancer 0 4 11270423 (3)

    Genetic Association Database (GAD): MT2A
    Human Genome Epidemiology (HuGE) Navigator: MT2A (15 documents)

    Export disorders for MT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT2A gene, integrated from 9 sources (see all 215):
    (articles sorted by number of sources associating them with MT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PubMed id 7133118)1, 2, 3 Karin M. and Richards R.I. (1982)
    2. The polymorphism of core promoter region on metalloth ionein 2A-metal binding protein in Turkish population. (PubMed id 19572214)1, 4, 9 Kayaalti Z. and SAPylemezoA9lu T. (2010)
    3. Expression of human metallothionein-II fusion protein in Escherichia coli. (PubMed id 1339282)1, 2, 9 Yamazaki S.... Kagawa Y. (1992)
    4. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PubMed id 2388267)1, 2, 9 Messerle B.A.... Wuethrich K. (1990)
    5. Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PubMed id 1593628)1, 2, 9 Messerle B.A.... Wuethrich K. (1992)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PubMed id 19515364)1, 4 Gundacker C....Gencik M. (2009)
    8. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. (PubMed id 18349110)1, 4 Yang L....Liu Y. (2008)
    9. The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people. (PubMed id 17622311)1, 4 Giacconi R....Mocchegiani E. (2007)
    10. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. (PubMed id 16546755)1, 4 Hayashi Y....Hozumi I. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4502 HGNC: 7406 AceView: MT2_ Ensembl:ENSG00000125148 euGenes: HUgn4502
    ECgene: MT2A Kegg: 4502 H-InvDB: MT2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT2A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mt2a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MT2A gene:
    Search GeneIP for patents involving MT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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