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MT2A Gene

protein-coding   GIFtS: 63
GCID: GC16P056642

Metallothionein 2A


(Previous symbol: MT2)
  See MT2A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 9

Aliases
Metallothionein 2A1 2     metallothionein-2A2
MT21 2 3 5     metallothionein-II2
MT-22 3     CES13
MT-II2 3     Metallothionein-2A3
metallothionein-22     Metallothionein-II3

External Ids:    HGNC: 74061   Entrez Gene: 45022   Ensembl: ENSG000001251487   OMIM: 1563605   UniProtKB: P027953   
ORGUL members:    fRNAdb10:FR000455      
H-InvDB12:HIT000101271 HIT000101271    
NCBI13:D28442    
RNAdb15:HIV1190    

Export aliases for MT2A gene to outside databases

Previous GC identifers: GC16P047025 GC16P056693 GC16P056376 GC16P056417 GC16P055199 GC16P042512


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT2A Gene:
MT2A (metallothionein 2A) is a protein-coding gene. Diseases associated with MT2A include cerebral lymphoma. GO annotations related to this gene include drug binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT2A (Metallothionein 2A) Gene

fRNAdb sequence ontology for MT2A:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MT2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT2A gene promoter:
         GR   p53   AP-1   ATF-2   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MT2A promoter sequence
   Search Chromatin IP Primers for MT2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT2A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056642:  view genomic region     (about GC identifiers)

Start:
56,642,111 bp from pter      End:
56,643,409 bp from pter
Size:
1,299 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MT2_HUMAN, P02795 (See protein sequence)
Recommended Name: Metallothionein-2  
Size: 61 amino acids; 6042 Da
Miscellaneous: This metallothionein binds zinc
2 PDB 3D structures from and Proteopedia for MT2A:
1MHU (3D)        2MHU (3D)    
Secondary accessions: Q14823 Q2HXR9 Q53XT9

Explore the universe of human proteins at neXtProt for MT2A: NX_P02795

Explore proteomics data for MT2A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys51
  • Modification sites at PhosphoSitePlus

  • See MT2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005944.1  
    ENSEMBL proteins: 
     ENSP00000245185   ENSP00000456804  
    Reactome Protein details: P02795

    MT2A Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MT2A 

     
    antibodies-online proteins for MT2A (17 products) 

     
    Search antibodies-online for peptides for MT2A

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    antibodies-online antibodies for MT2A (13 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P02795

    ProtoNet protein and cluster: P02795

    1 Blocks protein domain: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Find genes that share domains with MT2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT2_HUMAN, P02795
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT2A:
    metallothionein 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12646258
    GO:0008144drug binding IDA19536566
    GO:0008270zinc ion binding ISS--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with MT2A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MT2A:
     Decreased circadian period len  Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mt2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with MT2A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MT2A: Mt2tm1Bri Mt2tm1Rch

       genOway: Develop your customized and physiologically relevant rodent model for MT2A

    miRNA
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    miRTarBase miRNAs that target MT2A:
    hsa-mir-197-3p (MIRT004206)

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    Predesigned siRNA for gene silencing in human, mouse, rat MT2A

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT2A
    Addgene plasmids for MT2A 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular3
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm ISS--

    Find genes that share ontologies with MT2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT2A About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    3Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with MT2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MT2A
        Interferon gamma signaling

    1 PharmGKB Pathway for MT2A
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    1 Kegg Pathway  (Kegg details for MT2A):
        Mineral absorption

        Pathway & Disease-focused RT2 Profiler PCR Array including MT2A: 
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MT2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for MT2A (P027951, 2, 3 ENSP000002451854) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR50Q135851, 2, 3, ENSP000002183164EBI-996616,EBI-8550965 MINT-2836197 MINT-2836127 I2D: score=1 STRING: ENSP00000218316
    PRKD1Q151391, 3, ENSP000003335684EBI-996616,EBI-1181072 I2D: score=3 STRING: ENSP00000333568
    CXorf40AQ8TE691, 3EBI-996616,EBI-996609 I2D: score=2 
    SPINK7P580621, 3, ENSP000002745654EBI-996616,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    ADAMTS4O751733, ENSP000003569754I2D: score=1 STRING: ENSP00000356975
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006878cellular copper ion homeostasis TAS6719135
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035690cellular response to drug IDA19536566
    GO:0036016cellular response to interleukin-3 IEP11168427
    GO:0036018cellular response to erythropoietin IEP11168427

    Find genes that share ontologies with MT2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT2A (MT2)

    Selected Novoseek inferred chemical compound relationships for MT2A gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.3 29 19097988 (3), 17308060 (2), 16087360 (2), 12566070 (2) (see all 17)
    cadmium 66.6 23 16600086 (3), 18755257 (2), 17485079 (2), 16087360 (2) (see all 12)
    cdcl2 64 6 10403520 (2), 9545559 (2), 16402917 (1), 12566070 (1)
    copper 42 12 8552721 (5), 2066364 (2), 10471781 (1)
    arsenite 34.8 6 15725085 (3), 7999084 (2)
    n acetylcysteine 33.3 8 9545559 (2), 19097988 (1), 18586083 (1), 15725085 (1)
    silver nitrate 30.2 6 18586083 (4), 17308060 (1)
    cisplatin 27.1 6 10422815 (1)
    cysteine 23.8 1 16556599 (1)
    oligonucleotide 19.8 4 12173077 (1), 8134403 (1), 15583813 (1)



    Find genes that share compounds with MT2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for MT2A gene: 
    NM_005953.3  

    Unigene Cluster for MT2A:

    Metallothionein 2A
    Hs.534330  [show with all ESTs]
    Unigene Representative Sequence: BF131637
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245185(uc002ejh.3) ENST00000563985 ENST00000562017 ENST00000561491
    ENST00000567300
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MT2A
      QuantiFast Probe-based Assays in human, mouse, rat MT2A

    Additional mRNA sequence: 

    BC007034.1 BC062435.1 BC070289.1 BT007315.1 M26637.1 S52379.1 V00594.1 X97260.1 

    Selected DOTS entries (see all 35):

    DT.100058622  DT.91888226  DT.100893285  DT.101985063  DT.85102758  DT.100059597  DT.419190  DT.121273946 
    DT.87013827  DT.91641761  DT.120684886  DT.100893311  DT.100685880  DT.100893315  DT.218152  DT.101982092 
    DT.91705372  DT.120684782  DT.120684829  DT.120684958  DT.219307  DT.95200190  DT.97862507  DT.100800149 

    Selected AceView cDNA sequences (see all 231):

    BM760525 AI129861 CA446192 BQ181970 BQ433067 BX458790 NM_005954 AW026555 
    AJ713317 BU179329 BQ182739 BC035624 F28873 AJ573772 F28406 AU076535 
    AJ709369 BM887687 N71292 AA323224 CB155600 AW118531 BC070289 AV727158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCCAACT
    MT2A Expression
    About this image


    MT2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
    MT2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534330
        Pathway & Disease-focused RT2 Profiler PCR Array including MT2A: 
              Drug Metabolism in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MT2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MT2A gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mt25 metallothionein 2   --   8 (46.32 cM) 94172618 


    ENSEMBL Gene Tree for MT2A (if available)
    TreeFam Gene Tree for MT2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT2A gene
    MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT1HL12  MT1M2  MT1H2  
    MT1A2  
    14 SIMAP similar genes for MT2A using alignment to 2 protein entries:     MT2_HUMAN (see all proteins):
    MT1A    MT1L    MT1H    MT1B    MT1HL1    MT1J
    MTE    MT1G    MT1M    MT1F    MT3    MT1X
    MT4    MT1E

    Find genes that share paralogs with MT2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MT2A (see all 70)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409668111,2
    C--56640478(+) GACCAC/TCTGAG 1 -- us2k10--------
    rs1827136911,2
    --56640511(+) TATATA/GATACT 1 -- us2k10--------
    rs118655171,2
    C,F,H--56640675(+) gatgaA/Gtaaac 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs71965031,2
    C,F,A,H--56640739(+) AGTGGC/TCGAGT 1 -- us2k116Minor allele frequency- T:0.08NS EA NA WA CSA 968
    rs1854880981,2
    --56640813(+) GTGAGA/CACGCA 1 -- us2k10--------
    rs1511581081,2
    --56640967(+) TGGCCC/TGGTGC 1 -- us2k10--------
    rs802112711,2
    F--56641011(+) ATGACG/TGCCCT 1 -- us2k10--------
    rs790530101,2
    F--56641023(+) GGCATC/TTCCAG 1 -- us2k10--------
    rs348002571,2
    C,F--56641032(+) AGTGGT/CCAGGG 1 -- us2k17Minor allele frequency- C:0.05NS WA 308
    rs1464307571,2
    --56641077(+) GTCCCC/TGCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MT2A (56642111 - 56643409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MT2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714516CNV Deletion23290073
    nsv906720CNV Loss21882294

    Human Gene Mutation Database (HGMD): MT2A
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156360OMIM information: 156850 605013 605021 606668 607339 608558 608903 610260    
    1 disease for MT2A:    
    About MalaCards
    cerebral lymphoma


    Find genes that share disorders with MT2A           About GenesLikeMe

    10 Novoseek inferred disease relationships for MT2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21.3 7 11756227 (2), 11291768 (2), 15188022 (1), 15788722 (1) (see all 5)
    nasopharyngeal carcinoma 19.8 1 15583813 (1)
    shock 15.4 4 8552721 (1), 12016146 (1), 15734587 (1), 19540330 (1)
    tumors 4.55 10 18755257 (2), 15188022 (1), 11756227 (1), 12646258 (1) (see all 7)
    prostate cancer 3.62 2 10754528 (1), 14550308 (1)
    cancer 3.52 2 11756227 (1), 18341518 (1)
    asthma 0 1 16427169 (1)
    inflammation 0 2 15541360 (1), 16215939 (1)
    ovarian cancer 0 2 11077043 (1)
    bladder cancer 0 4 11270423 (3)

    Genetic Association Database (GAD): MT2A
    Human Genome Epidemiology (HuGE) Navigator: MT2A (15 documents)

    Export disorders for MT2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT2A gene, integrated from 10 sources (see all 224):
    (articles sorted by number of sources associating them with MT2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PubMed id 7133118)1, 2, 3 Karin M. and Richards R.I. (Nature 1982)
    2. The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population. (PubMed id 19572214)1, 4, 9 Kayaalti Z. and SAPylemezoA9lu T. (Mol. Biol. Rep. 2010)
    3. Expression of human metallothionein-II fusion protein in Escherichia coli. (PubMed id 1339282)1, 2, 9 Yamazaki S.... Kagawa Y. (Biochem. Int. 1992)
    4. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PubMed id 2388267)1, 2, 9 Messerle B.A.... Wuethrich K. (J. Mol. Biol. 1990)
    5. Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PubMed id 1593628)1, 2, 9 Messerle B.A.... Wuethrich K. (J. Mol. Biol. 1992)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PubMed id 19515364)1, 4 Gundacker C....Gencik M. (Environ. Res. 2009)
    8. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. (PubMed id 18349110)1, 4 Yang L....Liu Y. (Am. J. Physiol. Endocrinol. Metab. 2008)
    9. The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people. (PubMed id 17622311)1, 4 Giacconi R....Mocchegiani E. (Mol. Med. 2007)
    10. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. (PubMed id 16546755)1, 4 Hayashi Y....Hozumi I. (Amyotroph Lateral Scler 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4502 HGNC: 7406 AceView: MT2_ Ensembl:ENSG00000125148 euGenes: HUgn4502
    ECgene: MT2A Kegg: 4502 H-InvDB: MT2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MT2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT2A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mt2a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT2A gene:
    Search GeneIP for patents involving MT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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