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Aliases for MT2A Gene

Subcategory (RNA class) for MT2A Gene

lncRNA

Aliases for MT2A Gene

  • Metallothionein 2A 2 3
  • MT2 3 4 6
  • Metallothionein-2A 3 4
  • Metallothionein-II 3 4
  • MT-II 3 4
  • MT-2 3 4
  • Metallothionein-2 3
  • CES1 4

External Ids for MT2A Gene

ORGUL Members for MT2A Gene

Previous HGNC Symbols for MT2A Gene

  • MT2

Previous GeneCards Identifiers for MT2A Gene

  • GC16P047025
  • GC16P056693
  • GC16P056376
  • GC16P056417
  • GC16P055199
  • GC16P056642
  • GC16P042512

Summaries for MT2A Gene

GeneCards Summary for MT2A Gene

MT2A (Metallothionein 2A) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with MT2A include cerebral lymphoma and prostate cancer. Among its related pathways are Metabolism and the visual cycle I (vertebrates). GO annotations related to this gene include drug binding. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT2A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT2A Gene

fRNAdb sequence ontologies for MT2A Gene

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for MT2A

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for MT2A Gene

Genomics for MT2A Gene

Regulatory Elements for MT2A Gene

Genomic Location for MT2A Gene

Start:
56,608,199 bp from pter
End:
56,609,497 bp from pter
Size:
1,299 bases
Orientation:
Plus strand

Genomic View for MT2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT2A Gene

ORGUL Member Location for MT2A Gene

ORGUL Member Location for MT2A gene

Proteins for MT2A Gene

  • Protein details for MT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02795-MT2_HUMAN
    Recommended name:
    Metallothionein-2
    Protein Accession:
    P02795
    Secondary Accessions:
    • Q14823
    • Q2HXR9
    • Q53XT9

    Protein attributes for MT2A Gene

    Size:
    61 amino acids
    Molecular mass:
    6042 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This metallothionein binds zinc

    Three dimensional structures from OCA and Proteopedia for MT2A Gene

neXtProt entry for MT2A Gene

Proteomics data for MT2A Gene at MOPED

Post-translational modifications for MT2A Gene

  • Ubiquitination at Lys43 and Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for MT2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MT2A Gene

Domains for MT2A Gene

Gene Families for MT2A Gene

HGNC:
  • MT :Metallothioneins

Suggested Antigen Peptide Sequences for MT2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02795

UniProtKB/Swiss-Prot:

MT2_HUMAN :
  • P02795
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT2A: view

Function for MT2A Gene

Molecular function for MT2A Gene

GENATLAS Biochemistry: metallothionein 2
UniProtKB/Swiss-Prot Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008144 drug binding IDA 19536566
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT2A: view
genes like me logo Genes that share phenotypes with MT2A: view

Animal Models for MT2A Gene

MGI Knock Outs for MT2A:

miRNA for MT2A Gene

miRTarBase miRNAs that target MT2A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MT2A Gene

Localization for MT2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT2A Gene COMPARTMENTS Subcellular localization image for MT2A gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 3
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT2A Gene

Pathways for MT2A Gene

genes like me logo Genes that share pathways with MT2A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MT2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006878 cellular copper ion homeostasis TAS 6719135
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0035690 cellular response to drug IDA 19536566
GO:0036016 cellular response to interleukin-3 IEP 11168427
GO:0036018 cellular response to erythropoietin IEP 11168427
genes like me logo Genes that share ontologies with MT2A: view

Compounds for MT2A Gene

(23) Novoseek inferred chemical compound relationships for MT2A Gene

Compound -log(P) Hits PubMed IDs
zinc 67.3 22
cadmium 66.6 19
cdcl2 64 6
copper 42 8
arsenite 34.8 5
genes like me logo Genes that share compounds with MT2A: view

Transcripts for MT2A Gene

fRNAdb Secondary structures for MT2A Gene

  • FR000455

mRNA/cDNA for MT2A Gene

Unigene Clusters for MT2A Gene

Metallothionein 2A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT2A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT2A Gene

No ASD Table

Relevant External Links for MT2A Gene

GeneLoc Exon Structure for
MT2A
ECgene alternative splicing isoforms for
MT2A

Expression for MT2A Gene

mRNA expression in normal human tissues for MT2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT2A Gene

This gene is overexpressed in Liver (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT2A Gene

SOURCE GeneReport for Unigene cluster for MT2A Gene Hs.534330

genes like me logo Genes that share expressions with MT2A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MT2A Gene

Orthologs for MT2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT2A 35
  • 100 (n)
  • 100 (a)
MT2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT2 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MT2A 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mt1 36
  • 82 (a)
ManyToMany
Mt2 16
Species with no ortholog for MT2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT2A Gene

ENSEMBL:
Gene Tree for MT2A (if available)
TreeFam:
Gene Tree for MT2A (if available)

Paralogs for MT2A Gene

Paralogs for MT2A Gene

Selected SIMAP similar genes for MT2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MT2A: view

Variants for MT2A Gene

Sequence variations from dbSNP and Humsavar for MT2A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10636 -- 56,609,431(+) TGACC(C/G)TGACC utr-variant-3-prime
rs1054503 -- 56,609,398(+) CTTCC(A/C)CAAAC utr-variant-3-prime
rs1610216 -- 56,608,372(-) GCGCC(C/T)CGGGG upstream-variant-2KB
rs1875223 -- 56,609,225(-) ACTAG(C/G)GACAC intron-variant
rs7196503 -- 56,606,827(+) AGTGG(C/T)CGAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT2A Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
esv2714516 CNV Deletion 23290073

Relevant External Links for MT2A Gene

HapMap Linkage Disequilibrium report
MT2A
Human Gene Mutation Database (HGMD)
MT2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT2A Gene

Disorders for MT2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MT2A Gene including...

Search for MT2A Gene in MalaCards »

(10) Novoseek inferred disease relationships for MT2A Gene

Disease -log(P) Hits PubMed IDs
breast cancer 21.3 7
nasopharyngeal carcinoma 19.8 1
shock 15.4 4
tumors 4.55 8
prostate cancer 3.62 2

Relevant External Links for MT2A

Genetic Association Database (GAD)
MT2A
Human Genome Epidemiology (HuGE) Navigator
MT2A
genes like me logo Genes that share disorders with MT2A: view

No data available for UniProtKB/Swiss-Prot for MT2A Gene

Publications for MT2A Gene

  1. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PMID: 2388267) Messerle B.A. … Wuethrich K. (J. Mol. Biol. 1990) 3 4 23
  2. Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PMID: 1593628) Messerle B.A. … Wuethrich K. (J. Mol. Biol. 1992) 3 4 23
  3. Expression of human metallothionein-II fusion protein in Escherichia coli. (PMID: 1339282) Yamazaki S. … Kagawa Y. (Biochem. Int. 1992) 3 4 23
  4. The polymorphism of core promoter region on metallothionein 2A-metal binding protein in Turkish population. (PMID: 19572214) Kayaalti Z. … SAPylemezoA9lu T. (Mol. Biol. Rep. 2010) 3 23 48
  5. Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PMID: 7133118) Karin M. … Richards R.I. (Nature 1982) 2 3 4

Products for MT2A Gene

Sources for MT2A Gene

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