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Aliases for MT1X Gene

Aliases for MT1X Gene

  • Metallothionein 1X 2 3 5
  • Metallothionein-IX 3 4
  • MT-1X 3 4
  • MT-IX 3 4
  • Testicular Tissue Protein Li 124 3
  • Metallothionein-1X 3
  • MT-1L 3
  • MT1 3

External Ids for MT1X Gene

Previous HGNC Symbols for MT1X Gene

  • MT1

Previous GeneCards Identifiers for MT1X Gene

  • GC16U990045
  • GC16P056428
  • GC16P056486
  • GC16P056487
  • GC16P055267
  • GC16P055273
  • GC16P056711
  • GC16P042585
  • GC16P056719

Summaries for MT1X Gene

GeneCards Summary for MT1X Gene

MT1X (Metallothionein 1X) is a Protein Coding gene. Among its related pathways are Metabolism and Response to metal ions. An important paralog of this gene is MT2A.

UniProtKB/Swiss-Prot for MT1X Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).

Gene Wiki entry for MT1X Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1X Gene

Genomics for MT1X Gene

Regulatory Elements for MT1X Gene

Enhancers for MT1X Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F056685 1.2 ENCODE 27.4 +3.0 3012 1.3 JUND ATF3 POLR2A ZBTB33 NFE2 YY1 MT1X ENSG00000259827 DPPA2P4
GH16F056681 0.6 ENCODE 22.1 0.0 -5 3.2 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 ZNF121 ZNF143 MT1X CES1P2 MT1IP
GH16F056691 0.8 Ensembl ENCODE 17.9 +9.7 9661 1.7 TBP KLF1 PKNOX1 MAX THRB TEAD3 ZFHX2 CTBP1 POLR3A PRDM10 MT1X DPPA2P4 LOC105371287
GH16F056708 1.3 FANTOM5 Ensembl ENCODE 17.3 +27.1 27088 2.6 PKNOX1 ARNT FEZF1 ZNF48 ZBTB40 ZNF766 FOS ZBTB11 NCOA1 ELF1 NUP93 MT1X MT1H MT1G MT3 NLRC5 LOC105371287 LOC105371286
GH16F056677 0.5 ENCODE 15.5 -4.6 -4559 0.9 ZNF7 MT1X MT1IP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MT1X on UCSC Golden Path with GeneCards custom track

Promoters for MT1X Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052499 576 2401 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 ZNF143 SP3

Genomic Location for MT1X Gene

Chromosome:
16
Start:
56,682,424 bp from pter
End:
56,684,196 bp from pter
Size:
1,773 bases
Orientation:
Plus strand

Genomic View for MT1X Gene

Genes around MT1X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1X Gene

Proteins for MT1X Gene

  • Protein details for MT1X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80297-MT1X_HUMAN
    Recommended name:
    Metallothionein-1X
    Protein Accession:
    P80297
    Secondary Accessions:
    • A8MUC7

    Protein attributes for MT1X Gene

    Size:
    61 amino acids
    Molecular mass:
    6068 Da
    Quaternary structure:
    • Monomer. Interacts with FAM168A (PubMed:23251525).

neXtProt entry for MT1X Gene

Post-translational modifications for MT1X Gene

  • Ubiquitination at Lys 51
  • Modification sites at PhosphoSitePlus

Other Protein References for MT1X Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1X Gene

Domains & Families for MT1X Gene

Gene Families for MT1X Gene

Suggested Antigen Peptide Sequences for MT1X Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80297

UniProtKB/Swiss-Prot:

MT1X_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1X: view

Function for MT1X Gene

Molecular function for MT1X Gene

GENATLAS Biochemistry:
metallothionein 1X cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).

Gene Ontology (GO) - Molecular Function for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IEA,TAS 9074634
genes like me logo Genes that share ontologies with MT1X: view
genes like me logo Genes that share phenotypes with MT1X: view

Animal Model Products

miRNA for MT1X Gene

miRTarBase miRNAs that target MT1X

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1X Gene

Localization for MT1X Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1X Gene COMPARTMENTS Subcellular localization image for MT1X gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 8619255
GO:0005737 cytoplasm IDA 8619255
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1X: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1X Gene

Pathways & Interactions for MT1X Gene

genes like me logo Genes that share pathways with MT1X: view

Pathways by source for MT1X Gene

1 BioSystems pathway for MT1X Gene
1 KEGG pathway for MT1X Gene

Gene Ontology (GO) - Biological Process for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006882 cellular zinc ion homeostasis IEA --
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0010038 response to metal ion TAS 9074634
GO:0010273 detoxification of copper ion IEA --
GO:0036018 cellular response to erythropoietin IEP 11168427
genes like me logo Genes that share ontologies with MT1X: view

No data available for SIGNOR curated interactions for MT1X Gene

Drugs & Compounds for MT1X Gene

(3) Drugs for MT1X Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MT1X Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1X: view

Transcripts for MT1X Gene

mRNA/cDNA for MT1X Gene

Unigene Clusters for MT1X Gene

Metallothionein 1X:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1X Gene

No ASD Table

Relevant External Links for MT1X Gene

GeneLoc Exon Structure for
MT1X
ECgene alternative splicing isoforms for
MT1X

Expression for MT1X Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MT1X Gene

mRNA differential expression in normal tissues according to GTEx for MT1X Gene

This gene is overexpressed in Muscle - Skeletal (x8.1) and Liver (x6.5).

Protein differential expression in normal tissues from HIPED for MT1X Gene

This gene is overexpressed in Fetal Liver (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MT1X Gene



Protein tissue co-expression partners for MT1X Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MT1X Gene:

MT1X

SOURCE GeneReport for Unigene cluster for MT1X Gene:

Hs.374950
genes like me logo Genes that share expression patterns with MT1X: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MT1X Gene

Orthologs for MT1X Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1X Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1X 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia MT1E 35
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt1 35
  • 79 (a)
ManyToMany
Species where no ortholog for MT1X was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1X Gene

ENSEMBL:
Gene Tree for MT1X (if available)
TreeFam:
Gene Tree for MT1X (if available)

Paralogs for MT1X Gene

Paralogs for MT1X Gene

(14) SIMAP similar genes for MT1X Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MT1X: view

Variants for MT1X Gene

Sequence variations from dbSNP and Humsavar for MT1X Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111256701 -- 56,682,785(+) CCTGC(C/T)CCATG intron-variant
rs111606576 -- 56,683,302(+) TGCAG(A/G/T)CAGGG intron-variant
rs111771644 -- 56,681,005(+) TCAGA(C/T)GATAG upstream-variant-2KB
rs111866780 -- 56,683,490(+) GCCTC(A/C)TGATG intron-variant
rs112485803 -- 56,683,163(+) CTTGC(A/T)GTTGG splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for MT1X Gene

Variant ID Type Subtype PubMed ID
dgv2989n100 CNV gain 25217958
dgv524e214 CNV gain 21293372
nsv833244 CNV gain 17160897

Variation tolerance for MT1X Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1X Gene

Human Gene Mutation Database (HGMD)
MT1X
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1X Gene

Disorders for MT1X Gene

Relevant External Links for MT1X

Genetic Association Database (GAD)
MT1X
Human Genome Epidemiology (HuGE) Navigator
MT1X
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1X

No disorders were found for MT1X Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1X Gene

Publications for MT1X Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3 4 22 64
  2. Microarray-assisted pathway analysis identifies MT1X & NFI_B as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma. (PMID: 23251525) Peng B. … He Z. (PLoS ONE 2012) 3 4 64
  3. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PMID: 19817957) Segat L. … Crovella S. (J. Gastroenterol. Hepatol. 2009) 3 46 64
  4. [Cilostazol induces metallothionein expression in vascular cells]. (PMID: 19881214) Fujiwara Y. … Satoh M. (Yakugaku Zasshi 2009) 3 22 64
  5. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PMID: 16827180) Chang X.L. … Zhou Y.F. (Biomed. Environ. Sci. 2006) 3 22 64

Products for MT1X Gene

Sources for MT1X Gene

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