Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MT1X Gene

protein-coding   GIFtS: 55
GCID: GC16P056719

Metallothionein 1X


(Previous symbol: MT1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Metallothionein 1X1 2     MT-1l2
MT11 2     metallothionein-1X2
MT-1X2 3     metallothionein-IX2
MT-IX2 3     Metallothionein-IX3

External Ids:    HGNC: 74051   Entrez Gene: 45012   Ensembl: ENSG000001871937   OMIM: 1563595   UniProtKB: P802973   

Export aliases for MT1X gene to outside databases

Previous GC identifers: GC16U990045 GC16P056428 GC16P056486 GC16P056487 GC16P055267 GC16P055273 GC16P056711 GC16P042585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MT1X Gene:
MT1X (metallothionein 1X) is a protein-coding gene. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT1X gene promoter:
         STAT5B   STAT1   Sp1   STAT4   STAT1beta   STAT1alpha   STAT2   STAT3   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT1X promoter sequence
   Search Chromatin IP Primers for MT1X

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

MT1X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1X gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056719:  view genomic region     (about GC identifiers)

Start:
56,716,336 bp from pter      End:
56,718,108 bp from pter
Size:
1,773 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297 (See protein sequence)
Recommended Name: Metallothionein-1X  
Size: 61 amino acids; 6068 Da
Subunit: Monomer
Secondary accessions: A8MUC7

Explore the universe of human proteins at neXtProt for MT1X: NX_P80297

Explore proteomics data for MT1X at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys43, Lys51
  • Modification sites at PhosphoSitePlus

  • See MT1X Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005943.1  
    ENSEMBL proteins: 
     ENSP00000377995   ENSP00000475791   ENSP00000475537  

    MT1X Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MT1X
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MT1X
    GenScript Custom Purified and Recombinant Proteins Services for MT1X
    Novus Biologicals MT1X Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MT1X

     
    Search eBioscience for Proteins for MT1X 

    MT1X Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MT1X
    Search for Antibodies for MT1X at Abcam
    Cloud-Clone Corp. Antibodies for MT1X
    Search ThermoFisher Antibodies for MT1X
    LSBio Antibodies in human, mouse, rat for MT1X

    MT1X Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MT1X
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MT1X
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MT1X
    Cloud-Clone Corp. CLIAs for MT1X
    Search eBioscience for ELISAs for MT1X 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P80297

    ProtoNet protein and cluster: P80297

    1 Blocks protein domain: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Find genes that share domains with MT1X           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT1X_HUMAN, P80297
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1X:
    metallothionein 1X cluster

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding ISS--
    GO:0046872metal ion binding TAS9074634
         
    Find genes that share ontologies with MT1X           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT1X
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT1X

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT1X
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT1X

    miRNA
    Products:
        
    miRTarBase miRNAs that target MT1X:
    hsa-mir-192-5p (MIRT026466)

    Block miRNA regulation of human, mouse, rat MT1X using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate MT1X:
    hsa-miR-376b hsa-miR-376a hsa-miR-548c-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MT1X
    Predesigned siRNA for gene silencing in human, mouse, rat MT1X

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MT1X

    Clone
    Products:
         
    OriGene clones in human, mouse for MT1X (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MT1X (NM_005952)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1X

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MT1X
    Browse ESI BIO Cell Lines and PureStem Progenitors for MT1X 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1X


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8619255
    GO:0005737cytoplasm IDA8619255
    GO:0048471perinuclear region of cytoplasm ISS--

    Find genes that share ontologies with MT1X           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MT1X About    
    See pathways by source

    SuperPathContained pathways About
    1Oxidative Stress
    Oxidative Stress
    2Mineral absorption
    Mineral absorption


    Find genes that share SuperPaths with MT1X           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MT1X
        Oxidative Stress


    1 Kegg Pathway  (Kegg details for MT1X):
        Mineral absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT1X
    Interactions:

        GeneGlobe Interaction Network for MT1X

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MT1X (ENSP000003779954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF1ENSP000002766034STRING: ENSP00000276603
    TERF2IPENSP000003000864STRING: ENSP00000300086
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010038response to metal ion TAS9074634
    GO:0036018cellular response to erythropoietin IEP11168427
    GO:0045926negative regulation of growth ISS--
    GO:0071276cellular response to cadmium ion IEP16827180
    GO:0071294cellular response to zinc ion IEP11168427

    Find genes that share ontologies with MT1X           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT1X

    1 HMDB Compound for MT1X    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--

    5 Novoseek inferred chemical compound relationships for MT1X gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 65.7 5 18755257 (1), 20054154 (1), 8049263 (1), 16827180 (1) (see all 5)
    glyceraldehyde 3-phosphate 46.8 2 9831543 (1), 15952643 (1)
    zinc 26.4 3 17468938 (1), 10774930 (1), 10940647 (1)
    estrogen 21.1 2 17982697 (1), 16774941 (1)
    copper 8.54 1 9831543 (1)



    Find genes that share compounds with MT1X           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MT1X gene: 
    NM_005952.3  

    Unigene Cluster for MT1X:

    Metallothionein 1X
    Hs.374950  [show with all ESTs]
    Unigene Representative Sequence: BC053882
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394485(uc002ejy.3) ENST00000562939 ENST00000568370 ENST00000564974(uc002ejz.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MT1X using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate MT1X:
    hsa-miR-376b hsa-miR-376a hsa-miR-548c-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MT1X
    Predesigned siRNA for gene silencing in human, mouse, rat MT1X
    Clone
    Products:
         
    OriGene clones in human, mouse for MT1X (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MT1X (NM_005952)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1X
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MT1X
    OriGene qSTAR qPCR primer pairs in human, mouse for MT1X
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MT1X
      QuantiTect SYBR Green Assays in human, mouse, rat MT1X
      QuantiFast Probe-based Assays in human, mouse, rat MT1X

    Additional mRNA sequence: 

    AK311284.1 BC018190.1 BC032131.2 BC032338.1 BC053882.1 X76717.1 

    20 DOTS entries:

    DT.95091421  DT.100042494  DT.120684898  DT.85103340  DT.120684893  DT.120684786  DT.120684973  DT.99977794 
    DT.120684791  DT.120684884  DT.85101063  DT.100881113  DT.120684781  DT.95190528  DT.95190553  DT.100893285 
    DT.120684906  DT.120684982  DT.218152  DT.92387499 

    Selected AceView cDNA sequences (see all 139):

    CB529368 AJ712480 F25557 S68956 T29525 CD672936 AI341945 CD675632 
    F27787 T27991 F26333 F30567 BI821822 F30476 BX113499 BQ428187 
    AA344582 NM_005952 AI814448 AA973675 BC053882 BM923250 AA973227 X76717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MT1X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATCCTGAA
    MT1X Expression
    About this image


    MT1X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells
     
     Skeletal Muscle (Muscoskeletal System)
    MT1X Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT1X Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374950
        Custom PCR Arrays for MT1X
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MT1X
    OriGene qSTAR qPCR primer pairs in human, mouse for MT1X
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MT1X
    QuantiTect SYBR Green Assays in human, mouse, rat MT1X
    QuantiFast Probe-based Assays in human, mouse, rat MT1X
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1X

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
      --

    ENSEMBL Gene Tree for MT1X (if available)
    TreeFam Gene Tree for MT1X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MT1X gene
    MT1G2  MT1E2  MT1F2  MT1B2  MT2A2  MT1HL12  MT1M2  MT1H2  
    MT1A2  
    14 SIMAP similar genes for MT1X using alignment to 3 protein entries:     MT1X_HUMAN (see all proteins):
    MT1A    MT1L    MT1H    MT1G    MT1B    MT1HL1
    MT1E    MT1M    MTE    MT1F    MT1J    MT2A
    MT3    MT4

    Find genes that share paralogs with MT1X           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MT1X (see all 121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381889281,2
    C--56714396(+) AACAAC/TGCATT 1 -- us2k10--------
    rs713871341,2
    C,F--56714501(+) TGGTGC/TCTTGC 1 -- us2k14Minor allele frequency- T:0.05NA EA 244
    rs45317291,2
    C,F,A,H--56714520(+) aatgaT/Cctata 1 -- us2k1 tfbs332Minor allele frequency- C:0.42NS EA NA WA 3318
    rs1810574301,2
    C--56714575(+) CTAAAC/TGCTCG 1 -- us2k10--------
    rs1437708291,2
    --56714635(+) CTGAGG/TTGGTG 1 -- us2k10--------
    rs18272061,2
    C,F--56714747(-) TGGGTC/TCTCAC 1 -- us2k12Minor allele frequency- T:0.16WA EA 238
    rs124455981,2
    C,F,H--56714789(+) CCTCAC/TAAGAC 1 -- us2k16Minor allele frequency- T:0.29NA CSA 132
    rs99276641,2
    C,F,A--56714808(+) TGCTGA/GTGCCT 1 -- us2k18Minor allele frequency- G:0.42NA WA CSA 134
    rs118661501,2
    C,F,H--56714965(+) CCTGGA/TGTCCC 1 -- us2k12Minor allele frequency- T:0.10NA WA 120
    rs47847101,2
    C,F,A,H--56715158(+) CAATAT/CGTGAC 1 -- us2k113Minor allele frequency- C:0.48NA WA CSA EA 512

    HapMap Linkage Disequilibrium report for MT1X (56716336 - 56718108 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MT1X:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906720CNV Loss21882294
    nsv833244CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MT1X
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1X

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 156359    OMIM disorders: --


    Find genes that share disorders with MT1X           About GenesLikeMe

    4 Novoseek inferred disease relationships for MT1X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 34.2 4 10754528 (4)
    breast cancer 22.6 3 11756227 (1), 15788722 (1), 10940647 (1)
    bladder cancer 21.5 4 11270423 (4)
    tumors 3.27 2 18755257 (1), 11270423 (1)

    Genetic Association Database (GAD): MT1X
    Human Genome Epidemiology (HuGE) Navigator: MT1X (3 documents)

    Export disorders for MT1X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MT1X gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with MT1X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of six additional human metallothionein genes. (PubMed id 8049263)1, 2, 3, 9 Stennard F.A.... West A.K. (Biochim. Biophys. Acta 1994)
    2. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PubMed id 19817957)1, 4 Segat L....Crovella S. (J. Gastroenterol. Hepatol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Induction by zinc of specific metallothionein isoforms in human monocytes. (PubMed id 8119276)1, 2 Pauwels M.... Ley M. (Eur. J. Biochem. 1994)
    5. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1, 3 West A.K....Richards R.I. (Genomics 1990)
    6. Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. (PubMed id 10754528)1, 9 Garrett S.H....Sens D.A. (Prostate 2000)
    7. Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. (PubMed id 11693492)1, 9 Garrett S.H....Sens D.A. (J. Toxicol. Environ. Health Part A 2001)
    8. [Cilostazol induces metallothionein expression in vascular cells]. (PubMed id 19881214)1, 9 Fujiwara Y....Satoh M. (Yakugaku Zasshi 2009)
    9. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PubMed id 16827180)1, 9 Chang X.L....Zhou Y.F. (Biomed. Environ. Sci. 2006)
    10. Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PubMed id 11168427)1, 9 Rahman M.T. and De Ley M. (Eur. J. Biochem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4501 HGNC: 7405 AceView: MT1_ Ensembl:ENSG00000187193 euGenes: HUgn4501
    ECgene: MT1X Kegg: 4501 H-InvDB: MT1X

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MT1X Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MT1X gene:
    Search GeneIP for patents involving MT1X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MT1X  
     OriGene qPCR primer pairs and template standards for MT1X   OriGene Protein Over-expression Lysate for MT1X  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MT1X  
     OriGene qSTAR qPCR primer pairs in human, mouse for MT1X   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MT1X   OriGene Custom Protein Services for MT1X  

     
     
     Block miRNA regulation of human, mouse, rat MT1X using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MT1X
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1X Predesigned siRNA for gene silencing in human, mouse, rat MT1X
     QuantiFast Probe-based Assays in human, mouse, rat MT1X QuantiTect SYBR Green Assays in human, mouse, rat MT1X
     Custom PCR Arrays for MT1X Search Chromatin IP Primers for MT1X
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MT1X  GeneGlobe Interaction Network for MT1X
     Regulatory tfbs in MT1X promoter
     GenScript Custom Purified and Recombinant Proteins Services for MT1X GenScript cDNA clones with any tag delivered in your preferred vector for MT1X
     GenScript Custom Assay Services for MT1X GenScript Custom overexpressing Cell Line Services for MT1X
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MT1X
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MT1X lysates
     Search for Antibodies for MT1X at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MT1X
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MT1X
     Antibodies for MT1X
     ELISAs for MT1X
     CLIAs for MT1X



     Browse ESI BIO Cell Lines and PureStem Progenitors for MT1X
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1X
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MT1X
     SwitchGear Promoter luciferase reporter plasmids for MT1X
     Search ThermoFisher Antibodies for MT1X
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1X
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT1X
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT1X
     LSBio Antibodies in human, mouse, rat for MT1X
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MT1X
      Search eBioscience for proteins for MT1X
      Search eBioscience for elisas for MT1X
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MT1X gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4