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Aliases for MT1X Gene

Aliases for MT1X Gene

  • Metallothionein 1X 2 3 5
  • Metallothionein-IX 3 4
  • MT-1X 3 4
  • MT-IX 3 4
  • Testicular Tissue Protein Li 124 3
  • MT-1L 3
  • MT1 3

External Ids for MT1X Gene

Previous HGNC Symbols for MT1X Gene

  • MT1

Previous GeneCards Identifiers for MT1X Gene

  • GC16U990045
  • GC16P056428
  • GC16P056486
  • GC16P056487
  • GC16P055267
  • GC16P055273
  • GC16P056711
  • GC16P042585
  • GC16P056719

Summaries for MT1X Gene

GeneCards Summary for MT1X Gene

MT1X (Metallothionein 1X) is a Protein Coding gene. Among its related pathways are Metabolism and Mineral absorption. An important paralog of this gene is MT1E.

UniProtKB/Swiss-Prot for MT1X Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1X Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1X Gene

Genomics for MT1X Gene

Regulatory Elements for MT1X Gene

Promoters for MT1X Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MT1X on UCSC Golden Path with GeneCards custom track

Genomic Location for MT1X Gene

Chromosome:
16
Start:
56,682,424 bp from pter
End:
56,684,196 bp from pter
Size:
1,773 bases
Orientation:
Plus strand

Genomic View for MT1X Gene

Genes around MT1X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1X Gene

Proteins for MT1X Gene

  • Protein details for MT1X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80297-MT1X_HUMAN
    Recommended name:
    Metallothionein-1X
    Protein Accession:
    P80297
    Secondary Accessions:
    • A8MUC7

    Protein attributes for MT1X Gene

    Size:
    61 amino acids
    Molecular mass:
    6068 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1X Gene

Proteomics data for MT1X Gene at MOPED

Post-translational modifications for MT1X Gene

  • Ubiquitination at Lys 51
  • Modification sites at PhosphoSitePlus

Other Protein References for MT1X Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1X Gene

Domains & Families for MT1X Gene

Gene Families for MT1X Gene

Suggested Antigen Peptide Sequences for MT1X Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80297

UniProtKB/Swiss-Prot:

MT1X_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1X: view

Function for MT1X Gene

Molecular function for MT1X Gene

GENATLAS Biochemistry:
metallothionein 1X cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
genes like me logo Genes that share phenotypes with MT1X: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MT1X

miRNA for MT1X Gene

miRTarBase miRNAs that target MT1X

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1X Gene

Localization for MT1X Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1X Gene COMPARTMENTS Subcellular localization image for MT1X gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 8619255
genes like me logo Genes that share ontologies with MT1X: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1X Gene

Pathways & Interactions for MT1X Gene

genes like me logo Genes that share pathways with MT1X: view

Pathways by source for MT1X Gene

1 BioSystems pathway for MT1X Gene
1 KEGG pathway for MT1X Gene

Gene Ontology (GO) - Biological Process for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036018 cellular response to erythropoietin IEP 11168427
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
genes like me logo Genes that share ontologies with MT1X: view

No data available for SIGNOR curated interactions for MT1X Gene

Drugs & Compounds for MT1X Gene

(3) Drugs for MT1X Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MT1X Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1X: view

Transcripts for MT1X Gene

mRNA/cDNA for MT1X Gene

Unigene Clusters for MT1X Gene

Metallothionein 1X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1X Gene

No ASD Table

Relevant External Links for MT1X Gene

GeneLoc Exon Structure for
MT1X
ECgene alternative splicing isoforms for
MT1X

Expression for MT1X Gene

mRNA expression in normal human tissues for MT1X Gene

mRNA differential expression in normal tissues according to GTEx for MT1X Gene

This gene is overexpressed in Muscle - Skeletal (x8.1) and Liver (x6.5).

Protein differential expression in normal tissues from HIPED for MT1X Gene

This gene is overexpressed in Fetal Liver (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT1X Gene



SOURCE GeneReport for Unigene cluster for MT1X Gene Hs.374950

genes like me logo Genes that share expression patterns with MT1X: view

Protein tissue co-expression partners for MT1X Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MT1X Gene

Orthologs for MT1X Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1X Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1X 35
  • 100 (n)
  • 100 (a)
MT1X 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT1E 36
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt1 36
  • 79 (a)
ManyToMany
Species with no ortholog for MT1X:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1X Gene

ENSEMBL:
Gene Tree for MT1X (if available)
TreeFam:
Gene Tree for MT1X (if available)

Paralogs for MT1X Gene

Paralogs for MT1X Gene

(14) SIMAP similar genes for MT1X Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MT1X: view

Variants for MT1X Gene

Sequence variations from dbSNP and Humsavar for MT1X Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1599933 -- 56,681,950(-) CACAG(G/T)GCTCT upstream-variant-2KB
rs1827206 -- 56,680,835(-) TGGGT(C/T)CTCAC upstream-variant-2KB
rs2301232 -- 56,682,885(+) TGCCT(C/T)TTCGG intron-variant
rs2301233 -- 56,682,886(+) GCCTC(A/C/T)TCGGA intron-variant
rs2301234 -- 56,683,070(+) GTCCT(G/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MT1X Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
nsv833244 CNV Gain 17160897

Variation tolerance for MT1X Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1X Gene

HapMap Linkage Disequilibrium report
MT1X
Human Gene Mutation Database (HGMD)
MT1X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1X Gene

Disorders for MT1X Gene

Relevant External Links for MT1X

Genetic Association Database (GAD)
MT1X
Human Genome Epidemiology (HuGE) Navigator
MT1X
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1X

No disorders were found for MT1X Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1X Gene

Publications for MT1X Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3 4 23 67
  2. [Cilostazol induces metallothionein expression in vascular cells]. (PMID: 19881214) Fujiwara Y. … Satoh M. (Yakugaku Zasshi 2009) 3 23
  3. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PMID: 16827180) Chang X.L. … Zhou Y.F. (Biomed. Environ. Sci. 2006) 3 23
  4. Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PMID: 11168427) Rahman M.T. … De Ley M. (Eur. J. Biochem. 2001) 3 23
  5. Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. (PMID: 11693492) Garrett S.H. … Sens D.A. (J. Toxicol. Environ. Health Part A 2001) 3 23

Products for MT1X Gene

Sources for MT1X Gene

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