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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MT1X Gene

protein-coding GIFtS: 52
GCID: GC16P056719

metallothionein 1X

(Previous symbol: MT1)

Explore 10 diseases affiliated with
MT1X via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Metallothionein 1X¹ ²		MT-IX² ³
MT-1l¹ ²		Metallothionein-1X¹
MT1¹ ²		Metallothionein-IX³
MT-1X² ³		Metallothionein-IX³

External Ids:	HGNC: 7405¹	Entrez Gene: 4501²	Ensembl: ENSG00000187193⁷	OMIM: 156359⁵	UniProtKB: P80297³

Export aliases for MT1X gene to outside databases

Previous GC identifers: GC16U990045 GC16P056428 GC16P056486 GC16P056487 GC16P055267 GC16P055273 GC16P056711 GC16P042585

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297

Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are

transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1X

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MT1X gene promoter:
STAT5B STAT1 Sp1 STAT4 STAT1beta STAT1alpha STAT2 STAT3 Zic3 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MT1X promoter sequence

Search SABiosciences Chromatin IP Primers for MT1X

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1X

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q13

MT1X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1X gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P056719: view genomic region (about GC identifiers)

Start:	56,716,336 bp from pter	End:	56,718,108 bp from pter
Size:	1,773 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297 (See protein sequence)

Recommended Name: Metallothionein-1X

Size: 61 amino acids; 6068 Da

Subunit: Monomer

Secondary accessions: A8MUC7

Explore the universe of human proteins at neXtProt for MT1X: NX_P80297

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P80297

MT1X Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005943.1

ENSEMBL proteins:

ENSP00000377995 ENSP00000457024

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MT1X OriGene Custom Protein Services for MT1X
	GenScript Custom Purified and Recombinant Proteins Services for MT1X
	Novus Biologicals MT1X Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MT1X

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	8619255
GO:0005737	cytoplasm	IDA	8619255
GO:0048471	perinuclear region of cytoplasm	ISS	--

MT1X for ontologies About GeneDecksing

MT1X Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for MT1X
	Novus Biologicals MT1X Antibody
	Search for Antibodies for MT1X at Abcam
	Uscn Antibodies for MT1X
	Search ThermoFisher Antibodies for MT1X

Assay Products for MT1X:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MT1X
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MT1X

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MT1X for domains About GeneDecksing

5 InterPro domains/families:

IPR000006 Metalthion_vert

IPR018064 Metalthion_vert_metal_BS

IPR003019 Metalthion_sfam_euk

IPR023587 Metalthion_dom_vert

IPR017854 Metalthion_dom

Graphical View of Domain Structure for InterPro Entry P80297

ProtoNet protein and cluster: P80297

1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297

Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of

the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the

corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines

Similarity: Belongs to the metallothionein superfamily. Type 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MT1X_HUMAN, P80297

Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are

transcriptionally regulated by both heavy metals and glucocorticoids

Genatlas biochemistry entry for MT1X:

metallothionein 1X cluster

miRNA Products:		OriGene 3'-UTR Clone: MT1X Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT1X
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate MT1X:
		hsa-miR-376b hsa-miR-376a hsa-miR-548c-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1X OriGene shRNA RFP: MT1X OriGene siRNA: MT1X
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1X

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MT1X

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1X OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1X (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MT1X (NM_005952)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1X
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1X

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MT1X
		Search LifeMap BioReagents cell lines for MT1X

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1X

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	ISS	--
GO:0046872	metal ion binding	TAS	9074634

MT1X for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mineral absorption

Mineral absorption

1.00

Oxidative Stress

Oxidative Stress

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for MT1X

Oxidative Stress

1 Kegg Pathway (Kegg details for MT1X):

Mineral absorption

MT1X for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MT1X

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for MT1X (ENSP00000377995⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POT1	ENSP00000350249⁴	STRING: ENSP00000350249
TERF1	ENSP00000276603⁴	STRING: ENSP00000276603
TERF2IP	ENSP00000300086⁴	STRING: ENSP00000300086
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010038	response to metal ion	TAS	9074634
GO:0036018	cellular response to erythropoietin	IEP	11168427
GO:0045926	negative regulation of growth	ISS	--
GO:0071276	cellular response to cadmium ion	IEP	16827180
GO:0071294	cellular response to zinc ion	IEP	11168427

MT1X for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MT1X for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MT1X

1 HMDB Compound for MT1X About this table

Compound	Synonyms	CAS #	PubMed Ids
Cadmium	Cd (see all 6)	7440-43-9	--

5 Novoseek chemical compound relationships for MT1X gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cadmium	65.7	5	18755257 (1), 20054154 (1), 8049263 (1), 16827180 (1) (see all 5)
glyceraldehyde 3-phosphate	46.8	2	9831543 (1), 15952643 (1)
zinc	26.4	3	17468938 (1), 10774930 (1), 10940647 (1)
estrogen	21.1	2	17982697 (1), 16774941 (1)
copper	8.54	1	9831543 (1)

Search CenterWatch for drugs/clinical trials and news about MT1X

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MT1X gene:

NM_005952.3

Unigene Cluster for MT1X:

Metallothionein 1X

Hs.374950 [show with all ESTs]

Unigene Representative Sequence: BC053882

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394485(uc002ejy.3) ENST00000562939 ENST00000568370 ENST00000564974(uc002ejz.3)

miRNA Products:		OriGene 3'-UTR Clone: MT1X Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT1X
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate MT1X:
		hsa-miR-376b hsa-miR-376a hsa-miR-548c-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1X OriGene shRNA RFP: MT1X OriGene siRNA: MT1X
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1X

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1X OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1X (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MT1X (NM_005952)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1X
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1X

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MT1X Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MT1X
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1X
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1X

Additional cDNA sequence:

AK311284.1 BC018190.1 BC032131.2 BC032338.1 BC053882.1 X76717.1

20 DOTS entries:

DT.95091421 DT.100042494 DT.120684898 DT.85103340 DT.120684893 DT.120684786 DT.120684973 DT.99977794

DT.120684791 DT.120684884 DT.85101063 DT.100881113 DT.120684781 DT.95190528 DT.95190553 DT.100893285

DT.120684906 DT.120684982 DT.218152 DT.92387499

24/139 AceView cDNA sequences (see all 139):

CD675632 AJ712480 F30476 BX113499 F27787 BI821822 T29525 S68956

F30567 CB529368 CD672936 F26333 AI341945 F25557 T27991 AI358260

BM923250 BM971621 BG926575 AA323862 BX495641 CB117071 AW192642 BM920880

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MT1X expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATCCTGAA

About this image

MT1X expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MT1X Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT1X

SOURCE GeneReport for Unigene cluster: Hs.374950

SABiosciences Custom PCR Arrays for MT1X

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MT1X Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat MT1X
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1X
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1X

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1X

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MT1X gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MT3⁶	--	69(a)	1 → many	GL343675.1(182526-186438)
zebrafish (Danio rerio)	Actinopterygii	mt2⁶	metallothionein 2	63(a)	1 → many	18(17193795-17195147)

Species with no ortholog for MT1X

ENSEMBL Gene Tree for MT1X (if available)
TreeFam Gene Tree for MT1X (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MT1X gene

MT1G² MT1E² MT1F² MT1B² MT2A² MT4² MT1M² MT3²

MT1H² MT1A²

14 SIMAP similar genes for MT1X using alignment to 3 protein entries: MT1X_HUMAN (see all proteins):

MT1A MT1L MT1H MT1G MT1B MTP

MT1E MT1M MTE MT1F MT1J MT2A

MT3 MT4

MT1X for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138188928^1,2		--	56714396(+)	`AACAAC/TGCATT`	1	--	us2k¹		0	--	--	--	--
rs71387134^1,2	C,F,	--	56714501(+)	`TGGTGC/TCTTGC`	1	--	us2k¹		4		NA EA	244
rs4531729^1,2	C,F,A,H,	--	56714520(+)	`AATGAT/CCTATA`	1	--	us2k¹ tfbs³		32		NS EA NA WA	3318
rs181057430^1,2		--	56714575(+)	`CTAAAC/TGCTCG`	1	--	us2k¹		0	--	--	--	--
rs143770829^1,2		--	56714635(+)	`CTGAGG/TTGGTG`	1	--	us2k¹		0	--	--	--	--
rs1827206^1,2	F,	--	56714747(-)	`TGGGTC/TCTCAC`	1	--	us2k¹		2		WA EA	238
rs12445598^1,2	C,F,H,	--	56714789(+)	`CCTCAC/TAAGAC`	1	--	us2k¹		6		NA CSA	132
rs9927664^1,2	C,F,A,	--	56714808(+)	`TGCTGA/GTGCCT`	1	--	us2k¹		8		NA WA CSA	134
rs11866150^1,2	C,H,	--	56714965(+)	`CCTGGA/TGTCCC`	1	--	us2k¹		2		NA WA	120
rs4784710^1,2	C,F,A,H,	--	56715158(+)	`CAATAT/CGTGAC`	1	--	us2k¹		13		NA WA CSA EA	512

HapMap Linkage Disequilibrium report for MT1X (56716336 - 56718108 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MT1X: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1X

DNA2.0 Custom Variant and Variant Library Synthesis for MT1X

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MT1X for disorders           About GeneDecksing

OMIM gene information: 156359    OMIM disorders: --

10 diseases for MT1X:    About MalaCards

renal cell carcinoma keloids prostate cancer breast cancer

hepatocellular carcinoma pancreatic cancer prostatitis pancreatitis

carcinoma hypoxia

4 Novoseek disease relationships for MT1X gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	34.2	4	10754528 (4)
breast cancer	22.6	3	11756227 (1), 15788722 (1), 10940647 (1)
bladder cancer	21.5	4	11270423 (4)
tumors	3.27	2	18755257 (1), 11270423 (1)

Human Genome Epidemiology (HuGE) Navigator: MT1X (3 documents)

Export disorders for MT1X gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MT1X gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with MT1X)

Utopia: connect your pdf to the dynamic
world of online information

Characterisation of six additional human metallothionein genes. (PubMed id 8049263)^{1, 2, 3, 9} Stennard F.A....West A.K. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Induction by zinc of specific metallothionein isoforms in human monocytes. (PubMed id 8119276)^{1, 2} Pauwels M.... Ley M. (1994)
Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)^{1, 3} West A.K....Richards R.I. (1990)
Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. (PubMed id 10754528)^{1, 9} Garrett S.H....Sens D.A. (2000)
Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. (PubMed id 11693492)^{1, 9} Garrett S.H....Sens D.A. (2001)
[Cilostazol induces metallothionein expression in vas cular cells] (PubMed id 19881214)^{1, 9} Fujiwara Y....Satoh M. (2009)
Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PubMed id 16827180)^{1, 9} Chang X.L....Zhou Y.F. (2006)
Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PubMed id 11168427)^{1, 9} Rahman M.T. and De Ley M. (2001)
Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PubMed id 10774930)^{1, 9} Vandeghinste N....De Ley M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4501	HGNC: 7405	AceView: MT1_	Ensembl:ENSG00000187193	euGenes: HUgn4501
ECgene: MT1X	Kegg: 4501	H-InvDB: MT1X

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MT1X	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MT1X gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MT1X gene:
Search GeneIP for patents involving MT1X

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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MT1X Gene

metallothionein 1X

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MT1X Gene

metallothionein 1X

Aliasesfor MT1X gene

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Protein Domains /Familiesfor MT1X gene

Functionfor MT1X gene

Pathways & Interactionsfor MT1X gene

Drugs & Compoundsfor MT1X gene

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Expression for MT1X gene

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Disorders / Diseasesfor MT1X gene

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Other Databases showing MT1X gene

Specialized Databases showing MT1X gene

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for MT1X gene

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for MT1X gene

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for MT1X gene

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for MT1X gene

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for MT1X gene

Pathways & Interactions
for MT1X gene

Drugs & Compounds
for MT1X gene

Transcripts
for MT1X gene

Expression
for MT1X gene

Orthologs
for MT1X gene

Paralogs
for MT1X gene

Genomic Variants
for MT1X gene

Disorders / Diseases
for MT1X gene

Publications
for MT1X gene

Intellectual Property
for MT1X gene

Products
for MT1X gene