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Aliases for MT1M Gene

Aliases for MT1M Gene

  • Metallothionein 1M 2 3
  • Metallothionein 1K 2 3
  • MT-1M 3 4
  • MT-IM 3 4
  • MT1K 3 4
  • Metallothionein 1Y 3
  • Metallothionein-IM 4
  • MT1 3

External Ids for MT1M Gene

Previous HGNC Symbols for MT1M Gene

  • MT1
  • MT1K

Previous GeneCards Identifiers for MT1M Gene

  • GC16P055225
  • GC16P056666
  • GC16P042535

Summaries for MT1M Gene

Entrez Gene Summary for MT1M Gene

  • This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]

GeneCards Summary for MT1M Gene

MT1M (Metallothionein 1M) is a Protein Coding gene. Among its related pathways are Mineral absorption. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1M Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1M Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1M Gene

Genomics for MT1M Gene

Regulatory Elements for MT1M Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MT1M Gene

Chromosome:
16
Start:
56,632,233 bp from pter
End:
56,633,986 bp from pter
Size:
1,754 bases
Orientation:
Plus strand

Genomic View for MT1M Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT1M Gene

Proteins for MT1M Gene

  • Protein details for MT1M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N339-MT1M_HUMAN
    Recommended name:
    Metallothionein-1M
    Protein Accession:
    Q8N339
    Secondary Accessions:
    • Q8TDN3

    Protein attributes for MT1M Gene

    Size:
    61 amino acids
    Molecular mass:
    6110 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1M Gene

Proteomics data for MT1M Gene at MOPED

Post-translational modifications for MT1M Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1M Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1M Gene

Domains & Families for MT1M Gene

Gene Families for MT1M Gene

Suggested Antigen Peptide Sequences for MT1M Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N339

UniProtKB/Swiss-Prot:

MT1M_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1M: view

Function for MT1M Gene

Molecular function for MT1M Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1M: view

Phenotypes for MT1M Gene

GenomeRNAi human phenotypes for MT1M:
genes like me logo Genes that share phenotypes with MT1M: view

miRNA for MT1M Gene

miRTarBase miRNAs that target MT1M

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1M

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1M Gene

Localization for MT1M Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1M Gene COMPARTMENTS Subcellular localization image for MT1M gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for MT1M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1M: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1M Gene

Pathways & Interactions for MT1M Gene

SuperPathways for MT1M Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1M: view

Pathways by source for MT1M Gene

1 KEGG pathway for MT1M Gene

Interacting Proteins for MT1M Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369146%0d%0a9606.ENSP00000401721%0d%0a9606.ENSP00000221452%0d%0a
Selected Interacting proteins: ENSP00000369146 for MT1M Gene via STRING

Gene Ontology (GO) - Biological Process for MT1M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071294 cellular response to zinc ion ISS --
genes like me logo Genes that share ontologies with MT1M: view

No data available for SIGNOR curated interactions for MT1M Gene

Drugs & Compounds for MT1M Gene

(1) Additional Compounds for MT1M Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1M: view

Transcripts for MT1M Gene

mRNA/cDNA for MT1M Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1M Gene

Metallothionein 1M:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1M

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1M Gene

No ASD Table

Relevant External Links for MT1M Gene

GeneLoc Exon Structure for
MT1M
ECgene alternative splicing isoforms for
MT1M

Expression for MT1M Gene

mRNA expression in normal human tissues for MT1M Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT1M Gene

This gene is overexpressed in Liver (x11.3) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for MT1M Gene

This gene is overexpressed in Skin (52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1M Gene



SOURCE GeneReport for Unigene cluster for MT1M Gene Hs.647370

genes like me logo Genes that share expression patterns with MT1M: view

Protein tissue co-expression partners for MT1M Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MT1M Gene

Orthologs for MT1M Gene

Evolution for MT1M Gene

ENSEMBL:
Gene Tree for MT1M (if available)
TreeFam:
Gene Tree for MT1M (if available)

No data available for Orthologs for MT1M Gene

Paralogs for MT1M Gene

Paralogs for MT1M Gene

(12) SIMAP similar genes for MT1M Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MT1M Gene

genes like me logo Genes that share paralogs with MT1M: view

Variants for MT1M Gene

Sequence variations from dbSNP and Humsavar for MT1M Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1604123 -- 56,632,485(+) GGCGC(A/T)CTCGG upstream-variant-2KB
rs1827208 -- 56,632,974(+) TCCCG(C/T)TCCAC intron-variant
rs1827209 -- 56,633,253(+) GCACA(A/G)AGGAG intron-variant
rs1827210 - 56,633,370(+) CTGCA(A/C)GTGCA reference, missense
rs1846691 -- 56,632,533(+) TGGGC(A/T)CAGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1M Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294

Variation tolerance for MT1M Gene

Residual Variation Intolerance Score: 75.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1M Gene

HapMap Linkage Disequilibrium report
MT1M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1M Gene

Disorders for MT1M Gene

Relevant External Links for MT1M

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1M
genes like me logo Genes that share disorders with MT1M: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1M Gene

Publications for MT1M Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 23 67
  2. The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (PMID: 19472401) Oka D. … Ushijima T. (Cancer 2009) 23 67
  3. Effects of Zn(2+), Ca(2+), and Mg(2+) on the structure of Zn(7)metallothionein-3: evidence for an additional zinc binding site. (PMID: 19425569) Meloni G. … VasA!k M. (Biochemistry 2009) 23 67
  4. Smoking specifically induces metallothionein-2 isoform in human placenta at term. (PMID: 16621216) Ronco A.M. … Llanos M.N. (Toxicology 2006) 23 67
  5. Suppressed oxidant-induced apoptosis in cadmium adapted alveolar epithelial cells and its potential involvement in cadmium carcinogenesis. (PMID: 10924803) Eneman J.D. … Hart B.A. (Toxicology 2000) 23 67

Products for MT1M Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1M
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1M
    • Block miRNA regulation of MT1M using miScript Target Protectors

    Sources for MT1M Gene

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