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Aliases for MT1M Gene

Aliases for MT1M Gene

  • Metallothionein 1M 2 3 5
  • Metallothionein 1K 2 3
  • MT-1M 3 4
  • MT-IM 3 4
  • MT1K 3 4
  • Metallothionein 1Y 3
  • Metallothionein-1M 3
  • Metallothionein-IM 4
  • MT1 3

External Ids for MT1M Gene

Previous HGNC Symbols for MT1M Gene

  • MT1
  • MT1K

Previous GeneCards Identifiers for MT1M Gene

  • GC16P055225
  • GC16P056666
  • GC16P042535

Summaries for MT1M Gene

Entrez Gene Summary for MT1M Gene

  • This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]

GeneCards Summary for MT1M Gene

MT1M (Metallothionein 1M) is a Protein Coding gene. Among its related pathways are Response to metal ions and Mineral absorption. An important paralog of this gene is MT1E.

UniProtKB/Swiss-Prot for MT1M Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1M Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1M Gene

Genomics for MT1M Gene

Regulatory Elements for MT1M Gene

Enhancers for MT1M Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G056604 2 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -22.1 -22078 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 BBS2 MT1A MT1F MT1G MT1H MT3 MT1DP MT1CP MT1B POLR2C
GH16G056280 1.3 FANTOM5 ENCODE dbSUPER 1.6 -350.4 -350413 2.2 CTCF ZNF175 BACH1 CEBPG YBX1 RBBP5 RAD21 ZNF766 ZNF366 SMC3 GNAO1 MT3 MT1M BBS2 LOC102723466 ENSG00000279764
GH16G056303 0.7 FANTOM5 dbSUPER 1.6 -328.9 -328866 0.4 CEBPB GNAO1 MT3 BBS2 MT1M CES5A ENSG00000279764 LOC102723466
GH16G056516 0.7 FANTOM5 dbSUPER 1.4 -116.0 -115992 0.2 ZNF121 ZNF623 MT3 GNAO1 MT1G MT1H MT1A NUDT21 OGFOD1 BBS2 MT1M ENSG00000274031
GH16G056631 0.7 ENCODE 0.7 +0.2 241 1.5 SCRT1 RNF2 SUZ12 HLF CBX2 YY1 JUND ZFHX2 MXD3 SCRT2 MT1L MT1E CCL17 MT1JP MT1M
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MT1M on UCSC Golden Path with GeneCards custom track

Promoters for MT1M Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086300 167 401 RNF2 SUZ12 HLF CBX2 RAD21 YY1 JUND IKZF1 MXD3 EZH2

Genomic Location for MT1M Gene

Chromosome:
16
Start:
56,632,233 bp from pter
End:
56,633,986 bp from pter
Size:
1,754 bases
Orientation:
Plus strand

Genomic View for MT1M Gene

Genes around MT1M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1M Gene

Proteins for MT1M Gene

  • Protein details for MT1M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N339-MT1M_HUMAN
    Recommended name:
    Metallothionein-1M
    Protein Accession:
    Q8N339
    Secondary Accessions:
    • Q8TDN3

    Protein attributes for MT1M Gene

    Size:
    61 amino acids
    Molecular mass:
    6110 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1M Gene

Post-translational modifications for MT1M Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1M Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1M Gene

Domains & Families for MT1M Gene

Gene Families for MT1M Gene

Suggested Antigen Peptide Sequences for MT1M Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N339

UniProtKB/Swiss-Prot:

MT1M_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1M: view

Function for MT1M Gene

Molecular function for MT1M Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT1M: view

Phenotypes for MT1M Gene

GenomeRNAi human phenotypes for MT1M:
genes like me logo Genes that share phenotypes with MT1M: view

Animal Model Products

miRNA for MT1M Gene

miRTarBase miRNAs that target MT1M

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MT1M

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1M Gene

Localization for MT1M Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT1M gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1M: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1M Gene

Pathways & Interactions for MT1M Gene

genes like me logo Genes that share pathways with MT1M: view

Pathways by source for MT1M Gene

1 BioSystems pathway for MT1M Gene
1 KEGG pathway for MT1M Gene

Interacting Proteins for MT1M Gene

Selected Interacting proteins: Q8N339-MT1M_HUMAN for MT1M Gene via IID

Gene Ontology (GO) - Biological Process for MT1M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071294 cellular response to zinc ion ISS --
genes like me logo Genes that share ontologies with MT1M: view

No data available for SIGNOR curated interactions for MT1M Gene

Drugs & Compounds for MT1M Gene

(1) Additional Compounds for MT1M Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1M: view

Transcripts for MT1M Gene

mRNA/cDNA for MT1M Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1M Gene

Metallothionein 1M:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MT1M

Alternative Splicing Database (ASD) splice patterns (SP) for MT1M Gene

No ASD Table

Relevant External Links for MT1M Gene

GeneLoc Exon Structure for
MT1M
ECgene alternative splicing isoforms for
MT1M

Expression for MT1M Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1M Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT1M Gene

This gene is overexpressed in Liver (x11.3) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for MT1M Gene

This gene is overexpressed in Skin (52.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1M Gene



Protein tissue co-expression partners for MT1M Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1M Gene:

MT1M

SOURCE GeneReport for Unigene cluster for MT1M Gene:

Hs.647370

Evidence on tissue expression from TISSUES for MT1M Gene

  • Intestine(4.2)
  • Liver(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with MT1M: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1M Gene

Orthologs for MT1M Gene

Evolution for MT1M Gene

ENSEMBL:
Gene Tree for MT1M (if available)
TreeFam:
Gene Tree for MT1M (if available)

No data available for Orthologs for MT1M Gene

Paralogs for MT1M Gene

Paralogs for MT1M Gene

(12) SIMAP similar genes for MT1M Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MT1M Gene

genes like me logo Genes that share paralogs with MT1M: view

Variants for MT1M Gene

Sequence variations from dbSNP and Humsavar for MT1M Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1002637043 -- 56,631,668(+) GTGTA(A/G)ACTCA upstream-variant-2KB
rs1002996632 -- 56,631,402(+) CCTTC(C/G)CCTGT upstream-variant-2KB
rs1007089339 -- 56,630,797(+) TATCA(A/G)CACTA upstream-variant-2KB
rs1007552775 -- 56,631,163(+) CTGGA(A/G)TACAA upstream-variant-2KB
rs1012856472 -- 56,631,474(+) TGATC(A/G)TGGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1M Gene

Variant ID Type Subtype PubMed ID
dgv2988n100 CNV gain 25217958
dgv2989n100 CNV gain 25217958
dgv524e214 CNV gain 21293372
esv3582251 CNV loss 25503493

Variation tolerance for MT1M Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1M Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1M Gene

Disorders for MT1M Gene

Relevant External Links for MT1M

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1M

No disorders were found for MT1M Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1M Gene

Publications for MT1M Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human metallothionein genes: structure of the functional locus at 16q13. (PMID: 2286373) West A.K. … Richards R.I. (Genomics 1990) 2 3 64
  4. MiR-24-3p enhances cell growth in hepatocellular carcinoma by targeting metallothionein 1M. (PMID: 27650047) Dong X. … Guo W. (Cell Biochem. Funct. 2016) 3 64
  5. Low metallothionein 1M expression association with poor hepatocellular carcinoma prognosis after curative resection. (PMID: 27808371) Ding J. … Lu S.C. (Genet. Mol. Res. 2016) 3 64

Products for MT1M Gene

Sources for MT1M Gene

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