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MT1L Gene

pseudogene   GIFtS: 30
GCID: GC16P056651

Metallothionein 1L (Gene/Pseudogene)


(Previous symbol: MT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein 1L (Gene/Pseudogene)1 2     MT-1L3
MT11 2     MT-IL3
MT1R2     Metallothionein-IL3
MTF2     

External Ids:    HGNC: 74041   Entrez Gene: 45002   Ensembl: ENSG000002605497   OMIM: 1563585   UniProtKB: Q930833   

Export aliases for MT1L gene to outside databases

Previous GC identifers: GC16P047099 GC16P056767 GC16P056386 GC16P056430 GC16P056431 GC16P055208 GC16P042520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT1L Gene:
MT1L (metallothionein 1L (gene/pseudogene)) is a pseudogene. Diseases associated with MT1L include lymphoblastic leukemia, and prostate cancer.

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT1L gene promoter:
         GR   TBP   Sp1   AP-1   TFIID   GR-beta   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056651:  view genomic region     (about GC identifiers)

Start:
56,651,373 bp from pter      End:
56,652,730 bp from pter
Size:
1,358 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MT1L

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 (See protein sequence)
Recommended Name: Metallothionein-1L  
Size: 61 amino acids; 6062 Da
Subunit: Monomer (By similarity)

Explore the universe of human proteins at neXtProt for MT1L: NX_Q93083

Explore proteomics data for MT1L at MOPED


See MT1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MT: Metallothioneins

5 InterPro protein domains:
 IPR000006 Metalthion_vert
 IPR018064 Metalthion_vert_metal_BS
 IPR003019 Metalthion_sfam_euk
 IPR023587 Metalthion_dom_vert
 IPR017854 Metalthion_dom

Graphical View of Domain Structure for InterPro Entry Q93083

ProtoNet protein and cluster: Q93083

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Similarity: Belongs to the metallothionein superfamily. Type 1 family


MT1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MT1L_HUMAN, Q93083
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)

     Genatlas biochemistry entry for MT1L:
metallothionein 1L cluster

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT1L
Interactions:

    Search GeneGlobe Interaction Network for MT1L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MT1L

1 HMDB Compound for MT1L    About this table
CompoundSynonyms CAS #PubMed Ids
CadmiumCd (see all 6)7440-43-9--

1 Novoseek inferred chemical compound relationship for MT1L gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 44.7 3 14568174 (1), 9427845 (1)



MT1L for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for MT1L:

Metallothionein 1L (gene/pseudogene)
Hs.647358  [show with all ESTs]
Unigene Representative Sequence: BI835300
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000565768(uc002ejj.4) ENST00000566367
miRNA
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Additional mRNA sequence: 

BC070351.1 NR_001447.2 X97261.1 

4 DOTS entries:

DT.406271  DT.120684845  DT.120684801  DT.87013327 

Selected AceView cDNA sequences (see all 231):

AW118531 F28873 AW055185 BC013081 BM547245 AJ713317 BG180522 CB851102 
BQ433067 AV727158 AV702264 CR595825 AI206524 BM888358 AI952622 F28406 
AW043998 BX281399 BX356856 AW026555 BQ225213 AI418147 CR621046 NM_005954 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MT1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCTGTGCCA
MT1L Expression
About this image

MT1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MT1L Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.647358

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Tissue specificity: Expressed in reticulocytes

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for MT1L (if available)
TreeFam Gene Tree for MT1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MT1L gene
12 SIMAP similar genes for MT1L using alignment to 1 protein entry:     MT1L_HUMAN:
MT1A    MT1F    MT1H    MT2A    MT1B    MT1HL1
MT1X    MT1M    MTE    MT1E    MT1G    MT4

MT1L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MT1L (see all 79)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs129305101,2
C,F--42518852(+) gtaacA/Ccttga 1 -- us2k16Minor allele frequency- C:0.26NA EA 248
rs620360531,2
C,F--56649463(+) CCTAGT/CCAAGT 1 -- us2k15Minor allele frequency- C:0.10NA CSA WA EA 362
rs1394869071,2
--56649526(+) CAATGC/TTAAAA 1 -- us2k10--------
rs769253441,2
C,F--56649557(+) CAGACA/GTATCG 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs80556991,2
C,F,A--56649592(+) ATATAC/TACATA 1 -- us2k17Minor allele frequency- T:0.47NA WA CSA EA 365
rs80557241,2
C,F,A,H--56649637(+) CTGTCC/TAGGGT 1 -- us2k122Minor allele frequency- T:0.17NS EA NA WA CSA 2500
rs1507079521,2
C--56649676(+) ATTTC-/TTCTTT 1 -- us2k10--------
rs80557571,2
C,F,A--56649678(+) tttctC/Tttttt 1 -- us2k12Minor allele frequency- T:0.50NA WA 4
rs129295391,2
C,F--56649786(+) cttctG/Acctca 1 -- us2k12Minor allele frequency- A:0.25NA WA 4
rs1851276971,2
C--56649811(+) TGGGAC/GTACAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MT1L (56651373 - 56652730 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MT1L:    About this table    
Variant IDTypeSubtypePubMed ID
nsv906720CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for MT1L

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 156358    OMIM disorders: --

4 diseases for MT1L:    
About MalaCards
lymphoblastic leukemia    prostate cancer    prostatitis    leukemia


MT1L for disorders           About GeneDecksing


Export disorders for MT1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MT1L gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with MT1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. (PubMed id 9074634)1, 3, 9 Holloway A.F....West A.K. (FEBS Lett. 1997)
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (Hum. Genet. 2006)
  3. Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. (PubMed id 8766831)1, 2 Lambert E.... Swaminathan R. (FEBS Lett. 1996)
  4. Characterisation of six additional human metallothionein genes. (PubMed id 8049263)1, 3 Stennard F.A.... West A.K. (Biochim. Biophys. Acta 1994)
  5. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776)1 Sun N.N....Witten M.L. (Toxicol Ind Health 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1 West A.K....Richards R.I. (Genomics 1990)
  8. Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines. (PubMed id 15866122)9 Smid-Koopman E....Blok L.J. (J. Soc. Gynecol. Investig. 2005)
  9. Molecular analyses of metallothionein gene regulation. (PubMed id 9427845)9 Samson S.L. and Gedamu L. (Prog. Nucleic Acid Res. Mol. Biol. 1998)
  10. Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. (PubMed id 14568174)9 Hasumi M....Yamanaka H. (Cancer Lett. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4500 HGNC: 7404 AceView: MT2_ Ensembl:ENSG00000260549 euGenes: HUgn4500
ECgene: MT1L H-InvDB: MT1L

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MT1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MT1L gene:
Search GeneIP for patents involving MT1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search ThermoFisher Antibodies for MT1L
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT1L
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT1L
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT1L
 Search LSBio for Antibodies for MT1L
Customized transgenic rodents for:
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