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Aliases for MT1L Gene

Aliases for MT1L Gene

  • Metallothionein 1L, Pseudogene 2 3 5
  • Metallothionein 1L (Gene/Pseudogene) 2
  • Metallothionein 1R 3
  • Metallothionein-IL 4
  • MT-1L 4
  • MT-IL 4
  • MT1R 3
  • MTF 3
  • MT1 3

External Ids for MT1L Gene

Previous HGNC Symbols for MT1L Gene

  • MT1

Previous GeneCards Identifiers for MT1L Gene

  • GC16P047099
  • GC16P056767
  • GC16P056386
  • GC16P056430
  • GC16P056431
  • GC16P055208
  • GC16P056651
  • GC16P042520

Summaries for MT1L Gene

GeneCards Summary for MT1L Gene

MT1L (Metallothionein 1L, Pseudogene) is a Pseudogene. Among its related pathways are Copper homeostasis and Metal ion SLC transporters.

UniProtKB/Swiss-Prot for MT1L Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1L Gene

Genomics for MT1L Gene

Regulatory Elements for MT1L Gene

Enhancers for MT1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G056604 2 FANTOM5 Ensembl ENCODE dbSUPER 8.3 -7.3 -7306 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 BBS2 MT1A MT1F MT1G MT1H MT3 MT1DP MT1CP MT1B POLR2C
GH16G056616 0.9 ENCODE dbSUPER 10.6 +0.4 370 1.9 RNF2 SUZ12 TAF1 CBX2 MAX RBBP5 RAD21 YY1 HDAC2 POLR2A MT1A MT1F MT1G MT1H MT1CP MT1DP MT1B MT3 MT1E MT1X
GH16G056624 1 ENCODE 9.5 +8.8 8794 3.0 ARID4B FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNF143 FOS MXD4 MIER2 MT1E MT3 MT1G MT1H MT1B MT1F MT1X MT1A BBS2 NUP93
GH16G056667 1.3 Ensembl ENCODE 6.8 +51.4 51402 3.2 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF143 SP3 SP5 MT1X MT1L MT1G MT1H
GH16G056657 0.9 ENCODE 8.4 +40.6 40583 1.9 PKNOX1 ARID4B DMAP1 ZNF48 GLIS2 FOS DEK SP3 KAT8 GLIS1 MT1CP MT1L MT1X MT1E LOC101927536 MT1F
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MT1L on UCSC Golden Path with GeneCards custom track

Promoters for MT1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086296 -61 401 CTCF RNF2 SUZ12 TAF1 CBX2 MAX RBBP5 RAD21 HDAC2 POLR2A

Genomic Location for MT1L Gene

Chromosome:
16
Start:
56,617,461 bp from pter
End:
56,618,818 bp from pter
Size:
1,358 bases
Orientation:
Plus strand

Genomic View for MT1L Gene

Genes around MT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1L Gene

Proteins for MT1L Gene

  • Protein details for MT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93083-MT1L_HUMAN
    Recommended name:
    Metallothionein-1L
    Protein Accession:
    Q93083

    Protein attributes for MT1L Gene

    Size:
    61 amino acids
    Molecular mass:
    6062 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1L Gene

Post-translational modifications for MT1L Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT1L Gene

Domains & Families for MT1L Gene

Gene Families for MT1L Gene

Suggested Antigen Peptide Sequences for MT1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93083

UniProtKB/Swiss-Prot:

MT1L_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1L: view

Function for MT1L Gene

Molecular function for MT1L Gene

GENATLAS Biochemistry:
metallothionein 1L cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT1L Gene

Localization for MT1L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MT1L Gene

Pathways & Interactions for MT1L Gene

genes like me logo Genes that share pathways with MT1L: view

Pathways by source for MT1L Gene

2 BioSystems pathways for MT1L Gene

Interacting Proteins for MT1L Gene

Gene Ontology (GO) - Biological Process for MT1L Gene

None

No data available for SIGNOR curated interactions for MT1L Gene

Drugs & Compounds for MT1L Gene

(1) Drugs for MT1L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MT1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1L: view

Transcripts for MT1L Gene

mRNA/cDNA for MT1L Gene

(3) Additional mRNA sequences :
(231) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1L Gene

Metallothionein 1L (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1L Gene

No ASD Table

Relevant External Links for MT1L Gene

GeneLoc Exon Structure for
MT1L
ECgene alternative splicing isoforms for
MT1L

Expression for MT1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1L Gene

mRNA differential expression in normal tissues according to GTEx for MT1L Gene

This gene is overexpressed in Liver (x10.8).

Protein differential expression in normal tissues from HIPED for MT1L Gene

This gene is overexpressed in Pancreatic juice (56.7) and Fetal Liver (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1L Gene



Protein tissue co-expression partners for MT1L Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1L Gene:

MT1L

SOURCE GeneReport for Unigene cluster for MT1L Gene:

Hs.647358

mRNA Expression by UniProt/SwissProt for MT1L Gene:

Q93083-MT1L_HUMAN
Tissue specificity: Expressed in reticulocytes.
genes like me logo Genes that share expression patterns with MT1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1L Gene

Orthologs for MT1L Gene

Evolution for MT1L Gene

ENSEMBL:
Gene Tree for MT1L (if available)
TreeFam:
Gene Tree for MT1L (if available)

No data available for Orthologs for MT1L Gene

Paralogs for MT1L Gene

(12) SIMAP similar genes for MT1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1L: view

No data available for Paralogs for MT1L Gene

Variants for MT1L Gene

Sequence variations from dbSNP and Humsavar for MT1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000952910 -- 56,616,391(+) TGAGA(A/C)CCTGT upstream-variant-2KB
rs1001182142 -- 56,618,822(+) GATTC(A/G)GACCC downstream-variant-500B
rs1004016547 -- 56,617,164(+) TGGGG(G/T)TGGGA upstream-variant-2KB
rs1005684732 -- 56,618,498(+) TGGGT(C/G)TGGAG intron-variant
rs1005753849 -- 56,618,299(+) AGGGA(A/G)CTCCA intron-variant

Relevant External Links for MT1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT1L Gene

Disorders for MT1L Gene

Relevant External Links for MT1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1L

No disorders were found for MT1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1L Gene

Publications for MT1L Gene

  1. Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. (PMID: 9074634) Holloway A.F. … West A.K. (FEBS Lett. 1997) 2 3 22 64
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3 64
  3. Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. (PMID: 8766831) Lambert E. … Swaminathan R. (FEBS Lett. 1996) 3 4 64
  4. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3 64
  5. Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines. (PMID: 15866122) Smid-Koopman E. … Blok L.J. (J. Soc. Gynecol. Investig. 2005) 22 64

Products for MT1L Gene

Sources for MT1L Gene

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