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Aliases for MT1L Gene

Aliases for MT1L Gene

  • Metallothionein 1L (Gene/Pseudogene) 2 3
  • Metallothionein 1L (Pseudogene) 3
  • Metallothionein 1R 3
  • Metallothionein-IL 4
  • MT-1L 4
  • MT-IL 4
  • MT1R 3
  • MT1 3
  • MTF 3

External Ids for MT1L Gene

Previous Symbols for MT1L Gene

  • MT1

Summaries for MT1L Gene

GeneCards Summary for MT1L Gene

MT1L (Metallothionein 1L (Gene/Pseudogene)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MT1L Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1L Gene

Genomics for MT1L Gene

Genomic Location for MT1L Gene

Start:
56,617,461 bp from pter
End:
56,618,818 bp from pter
Size:
1,358 bases
Orientation:
Plus strand

Genomic View for MT1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1L Gene

Regulatory Elements for MT1L Gene

Proteins for MT1L Gene

  • Protein details for MT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93083-MT1L_HUMAN
    Recommended name:
    Metallothionein-1L
    Protein Accession:
    Q93083
    Secondary Accessions:

    Protein attributes for MT1L Gene

    Size:
    61 amino acids
    Molecular mass:
    6062 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1L Gene

Proteomics data for MT1L Gene at MOPED

Post-translational modifications for MT1L Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT1L Gene

Domains for MT1L Gene

Gene Families for MT1L Gene

HGNC:
  • MT :Metallothioneins

UniProtKB/Swiss-Prot:

MT1L_HUMAN
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines:
    • Q93083
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.:
    • Q93083
genes like me logo Genes that share domains with MT1L: view

Function for MT1L Gene

Molecular function for MT1L Gene

GENATLAS Biochemistry: metallothionein 1L cluster
UniProtKB/Swiss-Prot Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MT1L Gene

Localization for MT1L Gene

No data available for Gene Ontology (GO) - Cellular Components for MT1L Gene

Pathways for MT1L Gene

SuperPathways for MT1L Gene

No Data Available

Interacting Proteins for MT1L Gene

Gene Ontology (GO) - Biological Process for MT1L Gene

None

No data available for Pathways by source for MT1L Gene

Compounds for MT1L Gene

(1) HMDB Compounds for MT1L Gene

Compound Synonyms Cas Number PubMed IDs
Cadmium
  • Cd
7440-43-9

(1) Novoseek inferred chemical compound relationships for MT1L Gene

Compound -log(P) Hits PubMed IDs
zinc 44.7 2
genes like me logo Genes that share compounds with MT1L: view

Transcripts for MT1L Gene

mRNA/cDNA for MT1L Gene

Unigene Clusters for MT1L Gene

Metallothionein 1L (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1L Gene

No ASD Table

Relevant External Links for MT1L Gene

GeneLoc Exon Structure for
MT1L
ECgene alternative splicing isoforms for
MT1L

Expression for MT1L Gene

mRNA expression in normal human tissues for MT1L Gene

mRNA differential expression in normal tissues according to GTEx for MT1L Gene

This gene is overexpressed in Liver (10.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MT1L Gene

SOURCE GeneReport for Unigene cluster for MT1L Gene Hs.647358

mRNA Expression by UniProt/SwissProt for MT1L Gene

Q93083-MT1L_HUMAN
Tissue specificity: Expressed in reticulocytes
genes like me logo Genes that share expressions with MT1L: view

Orthologs for MT1L Gene

Evolution for MT1L Gene

ENSEMBL:
Gene Tree for MT1L (if available)
TreeFam:
Gene Tree for MT1L (if available)

No data available for Orthologs for MT1L Gene

Paralogs for MT1L Gene

Selected SIMAP similar genes for MT1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1L: view

No data available for Paralogs for MT1L Gene

Variants for MT1L Gene

Sequence variations from dbSNP and Humsavar for MT1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs904773 -- 56,617,689(+) GCAGA(A/C)GGGAA intron-variant
rs1132120 -- 56,618,782(+) TCTAT(G/T)AAATA nc-transcript-variant
rs2001985 -- 56,618,303(-) AGCCT(G/T)GAGTT intron-variant
rs2001986 -- 56,618,181(-) GGAGC(C/T)CCCTG nc-transcript-variant
rs2018703 -- 56,618,139(+) TCTTC(A/C)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MT1L Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294

Relevant External Links for MT1L Gene

HapMap Linkage Disequilibrium report
MT1L

Disorders for MT1L Gene

No disorders were found for MT1L Gene.

No data available for UniProtKB/Swiss-Prot for MT1L Gene

Publications for MT1L Gene

  1. Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. (PMID: 9074634) Holloway A.F. … West A.K. (FEBS Lett. 1997) 2 3 23
  2. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3
  3. Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. (PMID: 8766831) Lambert E. … Swaminathan R. (FEBS Lett. 1996) 3 4
  4. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 3
  5. Induction by zinc of specific metallothionein isoforms in human monocytes. (PMID: 8119276) Pauwels M. … Ley M. (Eur. J. Biochem. 1994) 23

Products for MT1L Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1L
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1L
    • Block miRNA regulation of MT1L using miScript Target Protectors

    Sources for MT1L Gene

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