metallothionein 1L (gene/pseudogene) (Previous symbol: MT1 )
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Aliasesfor MT1L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Metallothionein 1L (Gene/Pseudogene) 1 2 MT-1L3 MT11 2 MT-IL3 MT1R1 2 Metallothionein-IL3 MTF1 2
External Ids: HGNC: 7404 1 Entrez Gene: 4500 2 Ensembl: ENSG00000260549 7 OMIM: 156358 5 UniProtKB: Q93083 3 ORGUL members: NONCODE:n342483 n382995
Export aliases for MT1L gene to outside databases Previous GC identifers: GC16P047099 GC16P056767 GC16P056386 GC16P056430 GC16P056431 GC16P055208 GC16P042520
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Summariesfor MT1L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 Function : Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids (By similarity)
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Genomic Viewsfor MT1L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MT1L gene promoter: GR TBP Sp1 AP-1 TFIID GR-beta GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for MT1L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13 MT1L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P056651: view genomic region
(about GC identifiers )
Start:
56,651,373 bp from pter
End:
56,652,730 bp from pter
Size:
1,358 bases
Orientation:
plus strand
ORGUL member locations:Legend (see complete legend)
56651372 56807150 56962927 chr16
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Proteinsfor MT1L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 (See
protein sequence )Recommended Name: Metallothionein-1L Size : 61 amino acids; 6062 Da
Subunit : Monomer (By similarity)Explore the universe of human proteins at neXtProt for MT1L: NX_Q93083 MT1L Protein expression data from MOPED and PaxDb : --Human Recombinant Protein Products:
MT1L Antibody Products: Assay Products for MT1L:
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Protein
Domains / Familiesfor MT1L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MT1L for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q93083 ProtoNet protein and cluster: Q93083
UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 Domain : Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A ofthe alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines Similarity : Belongs to the metallothionein superfamily. Type 1 family
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Functionfor MT1L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 Function : Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids (By similarity)
Genatlas biochemistry entry for MT1L : metallothionein 1L cluster
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Pathways & Interactionsfor MT1L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1L
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Drugs & Compoundsfor MT1L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MT1L for compounds About GeneDecksing Browse Tocris compounds for MT1L 1 HMDB Compound for MT1L About this table 1 Novoseek chemical compound relationship for MT1L gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
zinc
44.7
3
14568174 (1), 9427845 (1)
Search CenterWatch for drugs/clinical trials and news about MT1L
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Transcriptsfor MT1L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section Unigene Cluster for MT1L:
Metallothionein 1L (gene/pseudogene) Hs.647358 [show with all ESTs ] Unigene Representative Sequence: BI835300 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000565768 (uc002ejj.4 ) ENST00000566367 Additional cDNA sequence: BC070351.1 NR_001447.2 X97261.1
4 DOTS entries : DT.406271 DT.120684845 DT.120684801 DT.87013327
24/231 AceView cDNA sequences (see all 231 ):
AJ705828 BM817906 BQ082159 BM888358 AJ711526 CB118333 BQ433067 BM887687 BQ182739 BQ050782 F30198 S52379 AI206524 AW026555 BG180522 BX281399 AJ709390 CR621046 AJ573411 CA446192 BQ014486 BQ181970 BM760525 AJ709369 GeneLoc Exon Structure
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Expression for MT1L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MT1L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCTGTGCCA
About this image MT1L expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Adult human kidney epithelial cells (Primary Cell)Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
SOURCE GeneReport for Unigene cluster: Hs.647358 UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 Tissue specificity : Expressed in reticulocytes SABiosciences Custom PCR Arrays for MT1L Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat MT1L Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MT1L
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Orthologsfor MT1L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for MT1L (if available)TreeFam Gene Tree for MT1L (if available)
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Paralogsfor MT1L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor MT1L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MT1L (56651373 - 56652730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MT1L: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor MT1L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MT1L for disorders About GeneDecksing
OMIM gene information: 156358
OMIM disorders : --6 diseases for MT1L : About MalaCards acute lymphoblastic leukemia lymphoblastic leukemia endometrial cancer leukemia prostate cancer prostatitis Export disorders for MT1L gene to outside databases
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Publicationsfor MT1L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MT1L gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with MT1L) Utopia : connect your pdf to the dynamic world of online information
Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. (PubMed id 9074634) 1 , 3, 9 Holloway A.F....West A.K. (1997) Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595) 1 , 3 Hahn Y. and Lee B. (2006) Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. (PubMed id 8766831) 1 , 2 Lambert E.... Swaminathan R. (1996) Characterisation of six additional human metallothionein genes. (PubMed id 8049263) 1 , 3 Stennard F.A....West A.K. (1994) Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776) 1 Sun N.N....Witten M.L. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373) 1 West A.K....Richards R.I. (1990) Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines. (PubMed id 15866122) 9 Smid-Koopman E....Blok L.J. (2005) Molecular analyses of metallothionein gene regulation. (PubMed id 9427845) 9 Samson S.L. and Gedamu L. (1998) Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. (PubMed id 14568174) 9 Hasumi M....Yamanaka H. (2003)
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External Searches for MT1L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MT1L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MT1L gene
(According to HUGE )
About This Section --
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Specialized Databases showing MT1L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MT1L Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MT1L gene: Search GeneIP for patents involving MT1L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MT1L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1L Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MT1L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MT1L Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1L
Search Tocris compounds for MT1L
MT1L Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for MT1L
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT1L
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