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Aliases for MT1L Gene

Aliases for MT1L Gene

  • Metallothionein 1L (Gene/Pseudogene) 2 3
  • Metallothionein 1L (Pseudogene) 3
  • Metallothionein 1R 3
  • Metallothionein-IL 4
  • MT-1L 4
  • MT-IL 4
  • MT1R 3
  • MT1 3
  • MTF 3

External Ids for MT1L Gene

Previous HGNC Symbols for MT1L Gene

  • MT1

Previous GeneCards Identifiers for MT1L Gene

  • GC16P047099
  • GC16P056767
  • GC16P056386
  • GC16P056430
  • GC16P056431
  • GC16P055208
  • GC16P056651
  • GC16P042520

Summaries for MT1L Gene

GeneCards Summary for MT1L Gene

MT1L (Metallothionein 1L (Gene/Pseudogene)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MT1L Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1L Gene

Genomics for MT1L Gene

Regulatory Elements for MT1L Gene

Genomic Location for MT1L Gene

Chromosome:
16
Start:
56,617,461 bp from pter
End:
56,618,818 bp from pter
Size:
1,358 bases
Orientation:
Plus strand

Genomic View for MT1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1L Gene

Proteins for MT1L Gene

  • Protein details for MT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93083-MT1L_HUMAN
    Recommended name:
    Metallothionein-1L
    Protein Accession:
    Q93083

    Protein attributes for MT1L Gene

    Size:
    61 amino acids
    Molecular mass:
    6062 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1L Gene

Proteomics data for MT1L Gene at MOPED

Post-translational modifications for MT1L Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT1L Gene

Domains & Families for MT1L Gene

Gene Families for MT1L Gene

Suggested Antigen Peptide Sequences for MT1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93083

UniProtKB/Swiss-Prot:

MT1L_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1L: view

Function for MT1L Gene

Molecular function for MT1L Gene

GENATLAS Biochemistry:
metallothionein 1L cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT1L Gene

Localization for MT1L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MT1L Gene

Pathways & Interactions for MT1L Gene

SuperPathways for MT1L Gene

No Data Available

Interacting Proteins for MT1L Gene

Gene Ontology (GO) - Biological Process for MT1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MT1L Gene

Drugs & Compounds for MT1L Gene

(1) Drugs for MT1L Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404

(1) Additional Compounds for MT1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1L: view

Transcripts for MT1L Gene

mRNA/cDNA for MT1L Gene

(3) Additional mRNA sequences :
(231) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1L Gene

Metallothionein 1L (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1L Gene

No ASD Table

Relevant External Links for MT1L Gene

GeneLoc Exon Structure for
MT1L
ECgene alternative splicing isoforms for
MT1L

Expression for MT1L Gene

mRNA expression in normal human tissues for MT1L Gene

mRNA differential expression in normal tissues according to GTEx for MT1L Gene

This gene is overexpressed in Liver (x10.8).

Protein differential expression in normal tissues from HIPED for MT1L Gene

This gene is overexpressed in Pancreatic juice (56.7) and Fetal Liver (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1L Gene



SOURCE GeneReport for Unigene cluster for MT1L Gene Hs.647358

mRNA Expression by UniProt/SwissProt for MT1L Gene

Q93083-MT1L_HUMAN
Tissue specificity: Expressed in reticulocytes
genes like me logo Genes that share expression patterns with MT1L: view

Protein tissue co-expression partners for MT1L Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MT1L Gene

Orthologs for MT1L Gene

Evolution for MT1L Gene

ENSEMBL:
Gene Tree for MT1L (if available)
TreeFam:
Gene Tree for MT1L (if available)

No data available for Orthologs for MT1L Gene

Paralogs for MT1L Gene

(12) SIMAP similar genes for MT1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1L: view

No data available for Paralogs for MT1L Gene

Variants for MT1L Gene

Sequence variations from dbSNP and Humsavar for MT1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs904773 -- 56,617,689(+) GCAGA(A/C)GGGAA intron-variant
rs1132120 -- 56,618,782(+) TCTAT(G/T)AAATA nc-transcript-variant
rs2001985 -- 56,618,303(-) AGCCT(G/T)GAGTT intron-variant
rs2001986 -- 56,618,181(-) GGAGC(C/T)CCCTG nc-transcript-variant
rs2018703 -- 56,618,139(+) TCTTC(A/C)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MT1L Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294

Relevant External Links for MT1L Gene

HapMap Linkage Disequilibrium report
MT1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MT1L Gene

Disorders for MT1L Gene

Relevant External Links for MT1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1L
genes like me logo Genes that share disorders with MT1L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1L Gene

Publications for MT1L Gene

  1. Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. (PMID: 9074634) Holloway A.F. … West A.K. (FEBS Lett. 1997) 2 23 67
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PMID: 16395595) Hahn Y. … Lee B. (Hum. Genet. 2006) 2 67
  3. Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines. (PMID: 15866122) Smid-Koopman E. … Blok L.J. (J. Soc. Gynecol. Investig. 2005) 23 67
  4. Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. (PMID: 14568174) Hasumi M. … Yamanaka H. (Cancer Lett. 2003) 23 67
  5. Molecular analyses of metallothionein gene regulation. (PMID: 9427845) Samson S.L. … Gedamu L. (Prog. Nucleic Acid Res. Mol. Biol. 1998) 23 67

Products for MT1L Gene

Sources for MT1L Gene

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