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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1L Gene

pseudogene   GIFtS: 33
GCID: GC16P056651

metallothionein 1L (gene/pseudogene)


(Previous symbol: MT1)
 Explore 6 diseases affiliated with
MT1L via our new
 Human Malady Compendium 
Biological research products
for MT1L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Metallothionein 1L (Gene/Pseudogene)1 2     MT-1L3
MT11 2     MT-IL3
MT1R1 2     Metallothionein-IL3
MTF1 2     

External Ids:    HGNC: 74041   Entrez Gene: 45002   Ensembl: ENSG000002605497   OMIM: 1563585   UniProtKB: Q930833   
ORGUL members:         
NONCODE:n342483 n382995    

Export aliases for MT1L gene to outside databases

Previous GC identifers: GC16P047099 GC16P056767 GC16P056386 GC16P056430 GC16P056431 GC16P055208 GC16P042520


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1L gene promoter:
         GR   TBP   Sp1   AP-1   TFIID   GR-beta   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MT1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056651:  view genomic region     (about GC identifiers)

Start:
56,651,373 bp from pter      End:
56,652,730 bp from pter
Size:
1,358 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

  • n382995
  • n342483
56651372 56807150 56962927 chr16

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083 (See protein sequence)
Recommended Name: Metallothionein-1L  
Size: 61 amino acids; 6062 Da
Subunit: Monomer (By similarity)

Explore the universe of human proteins at neXtProt for MT1L: NX_Q93083

MT1L Protein expression data from MOPED and PaxDb: --

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Uscn ELISAs and CLIAs for MT1L


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MT1L for domains           About GeneDecksing

5 InterPro domains/families:
 IPR000006 Metalthion_vert
 IPR018064 Metalthion_vert_metal_BS
 IPR003019 Metalthion_sfam_euk
 IPR023587 Metalthion_dom_vert
 IPR017854 Metalthion_dom

Graphical View of Domain Structure for InterPro Entry Q93083

ProtoNet protein and cluster: Q93083

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Similarity: Belongs to the metallothionein superfamily. Type 1 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)

     Genatlas biochemistry entry for MT1L:
metallothionein 1L cluster

miRNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MT1L for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MT1L

1 HMDB Compound for MT1L    About this table
CompoundSynonyms CAS #PubMed Ids
CadmiumCd (see all 6)7440-43-9--
1 Novoseek chemical compound relationship for MT1L gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 44.7 3 14568174 (1), 9427845 (1)

Search CenterWatch for drugs/clinical trials and news about MT1L 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for MT1L:

Metallothionein 1L (gene/pseudogene)
Hs.647358  [show with all ESTs]
Unigene Representative Sequence: BI835300
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000565768(uc002ejj.4) ENST00000566367

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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1L

Additional cDNA sequence: 

BC070351.1 NR_001447.2 X97261.1 

4 DOTS entries:

DT.406271  DT.120684845  DT.120684801  DT.87013327 

24/231 AceView cDNA sequences (see all 231):

AJ705828 BM817906 BQ082159 BM888358 AJ711526 CB118333 BQ433067 BM887687 
BQ182739 BQ050782 F30198 S52379 AI206524 AW026555 BG180522 BX281399 
AJ709390 CR621046 AJ573411 CA446192 BQ014486 BQ181970 BM760525 AJ709369 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MT1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGTGCCA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

MT1L expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Adult human kidney epithelial cells (Primary Cell)Kidney
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

SOURCE GeneReport for Unigene cluster: Hs.647358

UniProtKB/Swiss-Prot: MT1L_HUMAN, Q93083
Tissue specificity: Expressed in reticulocytes

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In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for MT1L (if available)
TreeFam Gene Tree for MT1L (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/69 NCBI SNPs in MT1L are shown (see all 69    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs620360531,2
F,--56649463(+) CCTAGT/CCAAGT 1 -- us2k15Minor allele frequency- C:0.10NA CSA WA EA 362
rs1394869071,2
--56649526(+) CAATGC/TTAAAA 1 -- us2k10--------
rs769253441,2
C,F,--56649557(+) CAGACA/GTATCG 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs80556991,2
C,F,A,--56649592(+) ATATAC/TACATA 1 -- us2k17Minor allele frequency- T:0.47NA WA CSA EA 365
rs80557241,2
C,F,A,H,--56649637(+) CTGTCC/TAGGGT 1 -- us2k122Minor allele frequency- T:0.17NS EA NA WA CSA 2500
rs1507079521,2
C,--56649673(+) ATTTC-/TTCTTT 1 -- us2k10--------
rs80557571,2
C,F,A,--56649678(+) TTTCTC/TTTTTT 1 -- us2k12Minor allele frequency- T:0.50NA WA 4
rs129295391,2
C,--56649786(+) cttctG/Acctca 1 -- us2k12Minor allele frequency- A:0.25NA WA 4
rs1851276971,2
--56649811(+) TGGGAC/GTACAG 1 -- us2k10--------
rs80547791,2
C,F,A,--56649831(+) accacG/Ttccgg 1 -- us2k14Minor allele frequency- T:0.19WA CSA NA 242

HapMap Linkage Disequilibrium report for MT1L (56651373 - 56652730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MT1L: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MT1L for disorders           About GeneDecksing

OMIM gene information: 156358    OMIM disorders: --

6 diseases for MT1L:    About MalaCards
acute lymphoblastic leukemia    lymphoblastic leukemia    endometrial cancer    leukemia
prostate cancer    prostatitis


Export disorders for MT1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MT1L gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MT1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein. (PubMed id 9074634)1, 3, 9 Holloway A.F....West A.K. (1997)
  2. Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (2006)
  3. Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes. (PubMed id 8766831)1, 2 Lambert E.... Swaminathan R. (1996)
  4. Characterisation of six additional human metallothionein genes. (PubMed id 8049263)1, 3 Stennard F.A....West A.K. (1994)
  5. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776)1 Sun N.N....Witten M.L. (2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1 West A.K....Richards R.I. (1990)
  8. Progesterone-induced inhibition of growth and differential regulation of gene expression in PRA- and/or PRB-expressing endometrial cancer cell lines. (PubMed id 15866122)9 Smid-Koopman E....Blok L.J. (2005)
  9. Molecular analyses of metallothionein gene regulation. (PubMed id 9427845)9 Samson S.L. and Gedamu L. (1998)
  10. Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. (PubMed id 14568174)9 Hasumi M....Yamanaka H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 4500 HGNC: 7404 AceView: MT2_ Ensembl:ENSG00000260549 euGenes: HUgn4500
ECgene: MT1L H-InvDB: MT1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MT1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MT1L gene:
Search GeneIP for patents involving MT1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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 Regulatory tfbs in MT1L promoter
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 Protein Production and Purification
 Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1L
 Browse SwitchGear 3'UTR luciferase reporter plasmids for MT1L
 Browse SwitchGear Promoter luciferase reporter plasmids for MT1L
 Search ThermoFisher Antibodies for MT1L
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT1L
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
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