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MT1JP Gene

pseudogene   GIFtS: 19
GCID: GC16P056669

Metallothionein 1J, Pseudogene

(Previous names: metallothionein 1N, pseudogene, metallothionein 1J)
(Previous symbols: MT1, MT1NP, MT1J)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein 1J, Pseudogene1 2     Metallothionein 1J1
MT1J1 2 5     Metallothionein 1N, Pseudogene1
MT11 2     MTB2
MT1NP1 2     

External Ids:    HGNC: 74021   Entrez Gene: 44982   Ensembl: ENSG000002559867   OMIM: 1563565   

Export aliases for MT1JP gene to outside databases

Previous GC identifer: GC16P055228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT1JP Gene:
MT1JP (metallothionein 1J, pseudogene) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT1JP
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1JP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

MT1JP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1JP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056669:  view genomic region     (about GC identifiers)

Start:
56,669,651 bp from pter      End:
56,670,998 bp from pter
Size:
1,348 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MT1JP

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MT: Metallothioneins

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for MT1JP

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT1JP
Interactions:

    Search GeneGlobe Interaction Network for MT1JP

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MT1JP



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000444023 ENST00000563395(uc002ejo.1) ENST00000564564(uc002ejp.1)

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Selected AceView cDNA sequences (see all 231):

BQ430119 BG180522 BQ181970 BE048260 BQ181442 BM766726 BU179032 F27839 
AW118531 CB155600 AA323224 AW043998 BX356856 BC070289 BQ225213 AJ709369 
AJ713317 AW275159 BQ050782 S52379 AA343368 CR625648 AJ573411 AJ705828 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MT1JP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCTGAGCCA
MT1JP Expression
About this image

MT1JP Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MT1JP
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for MT1JP (if available)
TreeFam Gene Tree for MT1JP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MT1JP (see all 49)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs562036511,2
C,F--56668403(+) GAGTTT/CTTCCT 1 -- us2k15Minor allele frequency- C:0.19WA CSA NA EA 362
rs99267461,2
C,F--56668551(+) TGACTC/TACTAT 1 -- us2k17Minor allele frequency- T:0.11NA WA EA 366
rs1842268301,2
--56668552(+) GACTCA/TCTATG 1 -- us2k10--------
rs605825351,2
C,F--56668558(+) CTATGT/AGGACT 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1487915501,2
--56668644(+) GCCACC/GTTCCC 1 -- us2k10--------
rs345910231,2
C--56668689(+) TTTTTT/-GGGTG 1 -- us2k11Minor allele frequency- -:0.50NA 2
rs1449610351,2
--56668703(+) TGGGTC/GGGGGG 1 -- us2k10--------
rs1870565801,2
--56668832(+) AGGTGC/TCCCCC 1 -- us2k10--------
rs96734911,2
C,F--56668922(+) GGACAG/TCCCAC 1 -- us2k18Minor allele frequency- T:0.32NA WA CSA EA 368
rs96742271,2
C,F--56668987(+) TGGAGA/CTTTAT 1 -- us2k15Minor allele frequency- C:0.20WA CSA NA EA 362

HapMap Linkage Disequilibrium report for MT1JP (56669651 - 56670998 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MT1JP:    About this table    
Variant IDTypeSubtypePubMed ID
esv2669588CNV Deletion23128226
nsv906720CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 156356    OMIM disorders: --


Find genes that share disorders with MT1JP           About GenesLikeMe


Export disorders for MT1JP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MT1JP gene integrated from 10 sources:
(articles sorted by number of sources associating them with MT1JP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterisation of six additional human metallothionein genes. (PubMed id 8049263)1, 3, 9 Stennard F.A.... West A.K. (Biochim. Biophys. Acta 1994)
  2. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1, 3 West A.K....Richards R.I. (Genomics 1990)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. (PubMed id 2581970)1 Schmidt C.J.... Hamer D.H. (J. Biol. Chem. 1985)
  5. Heavy metal and growth hormone pathways in metallothionein regulation in fish RTH-149 cell line. (PubMed id 19154796)9 Vergani L....Gallo G. (amp 2009)
  6. Polymerase chain reaction amplification and functional characterization of sockeye salmon histone H3, metallothionein-B, and protamine promoters. (PubMed id 8180631)9 Chan W.K. and Devlin R.H. (Mol. Marine Biol. Biotechnol. 1993)
  7. A nuclear factor binds to the metal regulatory elements of the mouse gene encoding metallothionein-I. (PubMed id 1870976)9 LabbAc S....SAcguin C. (Nucleic Acids Res. 1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4498 HGNC: 7402 AceView: MT2_ Ensembl:ENSG00000255986 euGenes: HUgn4498
ECgene: MT1JP H-InvDB: MT1JP

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MT1JP Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MT1JP gene:
Search GeneIP for patents involving MT1JP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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