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Aliases for MT1HL1 Gene

Aliases for MT1HL1 Gene

  • Metallothionein 1H Like 1 2 3 5
  • Metallothionein 1H-Like Protein 1 3
  • Metallothionein 1 Pseudogene 2 2
  • MT-1H-Like Protein 3
  • MT1P2 3

External Ids for MT1HL1 Gene

Previous HGNC Symbols for MT1HL1 Gene

  • MT1P2

Previous GeneCards Identifiers for MT1HL1 Gene

  • GC01M237171

Summaries for MT1HL1 Gene

Entrez Gene Summary for MT1HL1 Gene

  • This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013]

GeneCards Summary for MT1HL1 Gene

MT1HL1 (Metallothionein 1H Like 1) is a Protein Coding gene. Among its related pathways are Mineral absorption.

UniProtKB/Swiss-Prot for MT1HL1 Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1HL1 Gene

Genomics for MT1HL1 Gene

Regulatory Elements for MT1HL1 Gene

Enhancers for MT1HL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G237011 1.7 VISTA ENCODE dbSUPER 0.4 -8.0 -7964 2.3 FEZF1 ZNF2 ZNF766 GLIS2 ZNF263 SP3 ZNF518A ZNF610 SMARCA4 PBX2 HEATR1 ENSG00000230325 ENSG00000273058 RYR2 MT1HL1
GH01G236997 1.3 VISTA dbSUPER 0.4 +5.7 5654 2.9 ZSCAN18 ZBTB21 ZBTB40 ZNF697 ZNF664 ZNF121 ZNF791 POLR2A ZNF354C ZNF547 ENSG00000273058 MTR HEATR1 ENSG00000230325 RYR2 RPL35P1 GC01M236985 MT1HL1
GH01G237029 1.2 VISTA ENCODE dbSUPER 0.3 -26.5 -26541 3.6 FEZF1 ZIC2 HIC1 GLIS2 ZBTB48 PATZ1 ZNF600 NFE2 ZFP37 ZEB2 RYR2 ENSG00000273058 MT1HL1
GH01G237001 0.4 dbSUPER 0.7 +2.4 2430 1.8 ZNF121 SCRT2 RYR2 MT1HL1 GC01M236985
GH01G237016 0.4 ENCODE 0.4 -12.6 -12553 1.5 CHD7 RYR2 MT1HL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MT1HL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MT1HL1 Gene

Chromosome:
1
Start:
237,004,103 bp from pter
End:
237,004,418 bp from pter
Size:
316 bases
Orientation:
Minus strand

Genomic View for MT1HL1 Gene

Genes around MT1HL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1HL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1HL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1HL1 Gene

Proteins for MT1HL1 Gene

  • Protein details for MT1HL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DM35-M1BL1_HUMAN
    Recommended name:
    Metallothionein 1H-like protein 1
    Protein Accession:
    P0DM35

    Protein attributes for MT1HL1 Gene

    Size:
    61 amino acids
    Molecular mass:
    6094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MT1HL1 Gene

Post-translational modifications for MT1HL1 Gene

No Post-translational modifications

Other Protein References for MT1HL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1HL1 Gene

Domains & Families for MT1HL1 Gene

Gene Families for MT1HL1 Gene

Graphical View of Domain Structure for InterPro Entry

P0DM35

UniProtKB/Swiss-Prot:

M1BL1_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines (By similarity).
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines (By similarity).
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1HL1: view

No data available for Suggested Antigen Peptide Sequences for MT1HL1 Gene

Function for MT1HL1 Gene

Molecular function for MT1HL1 Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1HL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT1HL1: view

Phenotypes for MT1HL1 Gene

genes like me logo Genes that share phenotypes with MT1HL1: view

Animal Model Products

miRNA for MT1HL1 Gene

miRTarBase miRNAs that target MT1HL1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1HL1 Gene

Localization for MT1HL1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MT1HL1 Gene

Pathways & Interactions for MT1HL1 Gene

SuperPathways for MT1HL1 Gene

SuperPathway Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1HL1: view

Pathways by source for MT1HL1 Gene

1 KEGG pathway for MT1HL1 Gene

Interacting Proteins for MT1HL1 Gene

Gene Ontology (GO) - Biological Process for MT1HL1 Gene

None

No data available for SIGNOR curated interactions for MT1HL1 Gene

Drugs & Compounds for MT1HL1 Gene

No Compound Related Data Available

Transcripts for MT1HL1 Gene

mRNA/cDNA for MT1HL1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1HL1 Gene

No ASD Table

Relevant External Links for MT1HL1 Gene

GeneLoc Exon Structure for
MT1HL1
ECgene alternative splicing isoforms for
MT1HL1

Expression for MT1HL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1HL1 Gene

mRNA differential expression in normal tissues according to GTEx for MT1HL1 Gene

This gene is overexpressed in Heart - Left Ventricle (x18.8), Heart - Atrial Appendage (x13.5), and Liver (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of MT1HL1 Gene:

MT1HL1

SOURCE GeneReport for Unigene cluster for MT1HL1 Gene:

Hs.632513
genes like me logo Genes that share expression patterns with MT1HL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1HL1 Gene

Orthologs for MT1HL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1HL1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MT1 35
  • 85 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia MT1A 35
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt1 35
  • 75 (a)
ManyToMany
Species where no ortholog for MT1HL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1HL1 Gene

ENSEMBL:
Gene Tree for MT1HL1 (if available)
TreeFam:
Gene Tree for MT1HL1 (if available)

Paralogs for MT1HL1 Gene

(11) SIMAP similar genes for MT1HL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1HL1: view

No data available for Paralogs for MT1HL1 Gene

Variants for MT1HL1 Gene

Sequence variations from dbSNP and Humsavar for MT1HL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000016336 -- 237,005,561(+) CACAC(A/G)TCAAC upstream-variant-2KB
rs1000471326 -- 237,005,911(+) TAATT(G/T)TGTGC upstream-variant-2KB
rs1001540425 -- 237,005,325(+) GCAAA(G/T)AATCC upstream-variant-2KB
rs1001933349 -- 237,003,696(+) TTAAA(C/G)AATGA downstream-variant-500B
rs1002083272 -- 237,004,193(+) CAGGC(A/G)CAGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MT1HL1 Gene

Variant ID Type Subtype PubMed ID
nsv1005877 CNV gain 25217958

Variation tolerance for MT1HL1 Gene

Gene Damage Index Score: 2.08; 38.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1HL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1HL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1HL1 Gene

Disorders for MT1HL1 Gene

Relevant External Links for MT1HL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1HL1

No disorders were found for MT1HL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1HL1 Gene

Publications for MT1HL1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MT1HL1 Gene

Sources for MT1HL1 Gene

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