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Aliases for MT1HL1 Gene

Aliases for MT1HL1 Gene

  • Metallothionein 1H-Like 1 2 3
  • Metallothionein 1H-Like Protein 1 3
  • Metallothionein 1 Pseudogene 2 2
  • MT-1H-Like Protein 3
  • MT1P2 3

External Ids for MT1HL1 Gene

Previous HGNC Symbols for MT1HL1 Gene

  • MT1P2

Previous GeneCards Identifiers for MT1HL1 Gene

  • GC01M237171

Summaries for MT1HL1 Gene

Entrez Gene Summary for MT1HL1 Gene

  • This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at three internal amino acids, two of which are at metal-binding sites. [provided by RefSeq, Mar 2013]

GeneCards Summary for MT1HL1 Gene

MT1HL1 (Metallothionein 1H-Like 1) is a Protein Coding gene. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1HL1 Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1HL1 Gene

Genomics for MT1HL1 Gene

Genomic Location for MT1HL1 Gene

237,004,103 bp from pter
237,004,418 bp from pter
316 bases
Minus strand

Genomic View for MT1HL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1HL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1HL1 Gene

No data available for Regulatory Elements for MT1HL1 Gene

Proteins for MT1HL1 Gene

  • Protein details for MT1HL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metallothionein 1H-like protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MT1HL1 Gene

    61 amino acids
    Molecular mass:
    6094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MT1HL1 Gene

Proteomics data for MT1HL1 Gene at MOPED

Post-translational modifications for MT1HL1 Gene

No Post-translational modifications

Other Protein References for MT1HL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1HL1 Gene

Domains for MT1HL1 Gene

Gene Families for MT1HL1 Gene

  • MT :Metallothioneins

Graphical View of Domain Structure for InterPro Entry



  • P0DM35
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines (By similarity).
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1HL1: view

No data available for Suggested Antigen Peptide Sequences for MT1HL1 Gene

Function for MT1HL1 Gene

Molecular function for MT1HL1 Gene

UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1HL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT1HL1: view

miRNA for MT1HL1 Gene

miRTarBase miRNAs that target MT1HL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MT1HL1 Gene

Localization for MT1HL1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MT1HL1 Gene

Pathways for MT1HL1 Gene

SuperPathways for MT1HL1 Gene

No Data Available

Interacting Proteins for MT1HL1 Gene

Gene Ontology (GO) - Biological Process for MT1HL1 Gene


No data available for Pathways by source for MT1HL1 Gene

Transcripts for MT1HL1 Gene

mRNA/cDNA for MT1HL1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT1HL1 Gene

No ASD Table

Relevant External Links for MT1HL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT1HL1 Gene

mRNA expression in normal human tissues for MT1HL1 Gene

mRNA differential expression in normal tissues according to GTEx for MT1HL1 Gene

This gene is overexpressed in Heart - Left Ventricle (18.8), Heart - Atrial Appendage (13.5), and Liver (5.8).

SOURCE GeneReport for Unigene cluster for MT1HL1 Gene Hs.632513

genes like me logo Genes that share expressions with MT1HL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MT1HL1 Gene

Orthologs for MT1HL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1HL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MT1A 36
  • 80 (a)
(Canis familiaris)
Mammalia MT1 36
  • 85 (a)
(Mus musculus)
Mammalia Mt1 36
  • 75 (a)
(Pan troglodytes)
Mammalia -- 36
  • 84 (a)
Species with no ortholog for MT1HL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1HL1 Gene

Gene Tree for MT1HL1 (if available)
Gene Tree for MT1HL1 (if available)

Paralogs for MT1HL1 Gene

Paralogs for MT1HL1 Gene

Selected SIMAP similar genes for MT1HL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1HL1: view

Variants for MT1HL1 Gene

Sequence variations from dbSNP and Humsavar for MT1HL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1252163 -- 237,003,670(+) GAATT(A/G)GGAGA downstream-variant-500B
rs1252164 -- 237,003,938(+) GTGCT(A/C)TTCAC downstream-variant-500B
rs1252165 -- 237,004,744(+) tgagg(C/T)aggag upstream-variant-2KB
rs1252166 -- 237,004,993(+) gaaga(C/T)gaaaa upstream-variant-2KB
rs1252167 -- 237,006,305(+) ATTAC(A/C)GGTGT upstream-variant-2KB

Relevant External Links for MT1HL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MT1HL1 Gene

Disorders for MT1HL1 Gene

No disorders were found for MT1HL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MT1HL1 Gene

Publications for MT1HL1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for MT1HL1 Gene

Sources for MT1HL1 Gene

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