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MT1HL1 Gene

protein-coding   GIFtS: 25
GCID: GC01M237171

Metallothionein 1H-Like 1

(Previous name: metallothionein 1 pseudogene 2)
(Previous symbol: MT1P2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein 1H-Like 11 2
MT1P21 2
Metallothionein 1 Pseudogene 21
Metallothionein 1H-Like Protein 12
MT-1H-Like Protein2

External Ids:    HGNC: 318641   Entrez Gene: 6457452   Ensembl: ENSG000002440207   UniProtKB: P0DM353   

Export aliases for MT1HL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MT1HL1 Gene:
This gene is a retrotransposed gene, compared to MT1H (GeneID:4496). This retrogene is transcribed. It retains a
full-length CDS, and is assumed to be translated. Compared to the MT1H product, this protein product differs at
three internal amino acids, two of which are at metal-binding sites. (provided by RefSeq, Mar 2013)

GeneCards Summary for MT1HL1 Gene:
MT1HL1 (metallothionein 1H-like 1) is a protein-coding gene. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: M1BL1_HUMAN, P0DM35
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MT1HL1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1HL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q43

MT1HL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1HL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M237171:  view genomic region     (about GC identifiers)

Start:
237,167,347 bp from pter      End:
237,167,743 bp from pter
Size:
397 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: M1BL1_HUMAN, P0DM35 (See protein sequence)
Recommended Name: Metallothionein 1H-like protein 1  
Size: 61 amino acids; 6094 Da
Caution: Encoded by an expressed retrotransposed copy of the MT1H locus

Explore the universe of human proteins at neXtProt for MT1HL1: NX_P0DM35

REFSEQ proteins: NP_001263616.1  
ENSEMBL proteins: 
 ENSP00000476141  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MT: Metallothioneins

5 InterPro protein domains:
 IPR000006 Metalthion_vert
 IPR003019 Metalthion_sfam_euk
 IPR001368 TNFR/NGFR_Cys_rich_reg
 IPR023587 Metalthion_dom_vert
 IPR017854 Metalthion_dom

Graphical View of Domain Structure for InterPro Entry P0DM35

ProtoNet protein and cluster: P0DM35

UniProtKB/Swiss-Prot: M1BL1_HUMAN, P0DM35
Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines (By similarity)
Similarity: Belongs to the metallothionein superfamily. Type 1 family


Find genes that share domains with MT1HL1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: M1BL1_HUMAN, P0DM35
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with MT1HL1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MT1HL1 (M1BL1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MT1HL1 gene (2 alternative transcripts): 
NM_001039954.2  NM_001276687.1  

Unigene Cluster for MT1HL1:

Metallothionein 1H-like 1
Hs.632513
Unigene Representative Sequence: AF333388
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000464121(uc001hyk.1)
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Additional mRNA sequence: 

AF333388.1 BC133030.1 BC133032.1 

1 DOTS entry:

DT.456171 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MT1HL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MT1HL1 Expression
About this image

MT1HL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.632513
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for MT1HL1 (if available)
TreeFam Gene Tree for MT1HL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MT1HL1 gene
MT1G2  MT1E2  MT1F2  MT1X2  MT1B2  MT2A2  MT1M2  MT1H2  
MT1A2  
11 SIMAP similar genes for MT1HL1 using alignment to 1 protein entry:     M1BL1_HUMAN:
MT1A    MT1L    MT1F    MT1H    MT2A    MT1B
MT1X    MT1M    MTE    MT1E    MT1G

Find genes that share paralogs with MT1HL1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MT1HL1 (see all 81)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs12521631,2
C,F,O,H--237166970(+) GAATTG/AGGAGA 1 -- ds50019Minor allele frequency- A:0.05NS EA NA WA 676
rs1380772901,2
C--237166986(+) TTTAGA/TTGTGT 1 -- ds50010--------
rs1495136091,2
--237167067(+) CACGGA/GGAATG 1 -- ds50010--------
rs715618491,2
C--237167149(+) GTGTA-/GTTTCT
CACCTTTT
GTTTC
1 -- ds50011Minor allele frequency- GTTTCTCACCTTTT:0.50NA 2
rs2005709531,2
C--237167149(+) TGTGTA/TGNNNN 1 -- ds50010--------
rs784718021,2
C--237167158(+) CTCAC-/CTTTTG
TTTCTCAC
TTTTT
1 -- ds50010--------
rs66675131,2
C,A,H--237167159(+) CTCACT/CTTTTG 1 -- ds50013Minor allele frequency- C:0.00NS EA 298
rs1459191261,2
C--237167178(+) CTATAC/TTCACT 1 -- ds50010--------
rs46597621,2
C,F,A,H--237167218(+) CGTACA/GCCCAT 1 -- ds500121Minor allele frequency- G:0.41NS EA NA CSA 2111
rs12521641,2
C,F,H--237167238(+) GTGCTC/ATTCAC 1 -- ds500116Minor allele frequency- A:0.22NS EA NA WA 2220

HapMap Linkage Disequilibrium report for MT1HL1 (237167347 - 237167743 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MT1HL1: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MT1HL1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MT1HL1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MT1HL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 645745 HGNC: 31864 Ensembl:ENSG00000244020 euGenes: HUgn645745 ECgene: MT1HL1
H-InvDB: MT1HL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MT1HL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MT1HL1 gene:
Search GeneIP for patents involving MT1HL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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