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Aliases for MT1H Gene

Aliases for MT1H Gene

  • Metallothionein 1H 2 3 5
  • Metallothionein-IH 3 4
  • Metallothionein-0 3 4
  • MT-1H 3 4
  • MT-IH 3 4
  • MT-0 3 4
  • Testicular Tissue Protein Li 123 3
  • Metallothionein-1H 3
  • MT1 3

External Ids for MT1H Gene

Previous HGNC Symbols for MT1H Gene

  • MT1

Previous GeneCards Identifiers for MT1H Gene

  • GC16P047075
  • GC16P056742
  • GC16P056427
  • GC16P056445
  • GC16P055250
  • GC16P055261
  • GC16P056703
  • GC16P042573

Summaries for MT1H Gene

GeneCards Summary for MT1H Gene

MT1H (Metallothionein 1H) is a Protein Coding gene. Among its related pathways are Response to metal ions and Metabolism.

UniProtKB/Swiss-Prot for MT1H Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1H Gene

Genomics for MT1H Gene

Regulatory Elements for MT1H Gene

Enhancers for MT1H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MT1H on UCSC Golden Path with GeneCards custom track

Genomic Location for MT1H Gene

Chromosome:
16
Start:
56,669,814 bp from pter
End:
56,671,129 bp from pter
Size:
1,316 bases
Orientation:
Plus strand

Genomic View for MT1H Gene

Genes around MT1H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1H Gene

Proteins for MT1H Gene

  • Protein details for MT1H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80294-MT1H_HUMAN
    Recommended name:
    Metallothionein-1H
    Protein Accession:
    P80294
    Secondary Accessions:
    • B2RUY6

    Protein attributes for MT1H Gene

    Size:
    61 amino acids
    Molecular mass:
    6039 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1H Gene

Post-translational modifications for MT1H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1H Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1H Gene

Domains & Families for MT1H Gene

Gene Families for MT1H Gene

Suggested Antigen Peptide Sequences for MT1H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80294

UniProtKB/Swiss-Prot:

MT1H_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1H: view

Function for MT1H Gene

Molecular function for MT1H Gene

GENATLAS Biochemistry:
metallothionein 1H cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008270 zinc ion binding ISS --
genes like me logo Genes that share ontologies with MT1H: view

Phenotypes for MT1H Gene

GenomeRNAi human phenotypes for MT1H:
genes like me logo Genes that share phenotypes with MT1H: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT1H Gene

Localization for MT1H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1H Gene COMPARTMENTS Subcellular localization image for MT1H gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MT1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1H: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1H Gene

Pathways & Interactions for MT1H Gene

genes like me logo Genes that share pathways with MT1H: view

Pathways by source for MT1H Gene

1 KEGG pathway for MT1H Gene

Gene Ontology (GO) - Biological Process for MT1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 8119276
genes like me logo Genes that share ontologies with MT1H: view

No data available for SIGNOR curated interactions for MT1H Gene

Drugs & Compounds for MT1H Gene

(1) Drugs for MT1H Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MT1H Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1H: view

Transcripts for MT1H Gene

mRNA/cDNA for MT1H Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1H Gene

Metallothionein 1H:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1H Gene

No ASD Table

Relevant External Links for MT1H Gene

GeneLoc Exon Structure for
MT1H
ECgene alternative splicing isoforms for
MT1H

Expression for MT1H Gene

mRNA expression in normal human tissues for MT1H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT1H Gene

This gene is overexpressed in Liver (x28.6) and Kidney - Cortex (x9.2).

Protein differential expression in normal tissues from HIPED for MT1H Gene

This gene is overexpressed in Fetal Liver (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MT1H Gene



Protein tissue co-expression partners for MT1H Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1H Gene:

MT1H

SOURCE GeneReport for Unigene cluster for MT1H Gene:

Hs.438462
genes like me logo Genes that share expression patterns with MT1H: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MT1H Gene

Orthologs for MT1H Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1H 34
  • 99.45 (n)
  • 100 (a)
-- 35
  • 98 (a)
OneToMany
MT1H 35
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MT1E 35
  • 80 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt2 35
  • 84 (a)
ManyToMany
Species where no ortholog for MT1H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1H Gene

ENSEMBL:
Gene Tree for MT1H (if available)
TreeFam:
Gene Tree for MT1H (if available)

Paralogs for MT1H Gene

(12) SIMAP similar genes for MT1H Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MT1H: view

No data available for Paralogs for MT1H Gene

Variants for MT1H Gene

Sequence variations from dbSNP and Humsavar for MT1H Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs9934181 -- 56,670,526(+) GCGCC(A/G)GCTCC reference, missense
rs9934420 -- 56,670,776(+) AAAAA(G/T)CTGTG intron-variant
rs17850317 -- 56,670,543(+) TGCAA(A/G)AAGTG reference, synonymous-codon
rs35266495 -- 56,670,853(+) GAGCT(-/C)CCCTG intron-variant
rs71381131 -- 56,671,043(+) TTTTT(-/T)CTACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MT1H Gene

Variant ID Type Subtype PubMed ID
dgv2988n100 CNV gain 25217958
dgv2989n100 CNV gain 25217958
dgv480n67 CNV loss 20364138
dgv524e214 CNV gain 21293372
nsv1058153 CNV gain 25217958
nsv827679 CNV loss 20364138
nsv827682 CNV gain 20364138
nsv974819 CNV duplication 23825009

Variation tolerance for MT1H Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1H Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1H Gene

Disorders for MT1H Gene

Relevant External Links for MT1H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1H

No disorders were found for MT1H Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1H Gene

Publications for MT1H Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3 4 22 65
  2. Induction by zinc of specific metallothionein isoforms in human monocytes. (PMID: 8119276) Pauwels M. … Ley M. (Eur. J. Biochem. 1994) 3 4 22 65
  3. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PMID: 16827180) Chang X.L. … Zhou Y.F. (Biomed. Environ. Sci. 2006) 3 22 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PMID: 10774930) Vandeghinste N. … De Ley M. (Cell. Mol. Biol. (Noisy-le-grand) 2000) 3 22 65

Products for MT1H Gene

Sources for MT1H Gene

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