Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1H Gene

protein-coding   GIFtS: 51
GCID: GC16P056703

metallothionein 1H


(Previous symbol: MT1)
 Explore 14 diseases affiliated with
MT1H via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MT1H    

Aliases
for MT1H gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metallothionein 1H1 2     Metallothionein-03
MT11 2     Metallothionein-1H1
MT-02 3     Metallothionein-IH3
MT-1H2 3     Metallothionein-03
MT-IH2 3     Metallothionein-IH3

External Ids:    HGNC: 74001   Entrez Gene: 44962   Ensembl: ENSG000002053587   OMIM: 1563545   UniProtKB: P802943   

Export aliases for MT1H gene to outside databases

Previous GC identifers: GC16P047075 GC16P056742 GC16P056427 GC16P056445 GC16P055250 GC16P055261 GC16P042573


Summaries
for MT1H gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MT1H_HUMAN, P80294
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1H


Genomic Views
for MT1H gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1H gene promoter:
         HEN1   STAT5B   Sp1   Zic3   Roaz   E47   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MT1H promoter sequence
   Search SABiosciences Chromatin IP Primers for MT1H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

MT1H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1H gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056703:  view genomic region     (about GC identifiers)

Start:
 56,703,726 bp from pter      End:
 56,705,041 bp from pter
Size:
 1,316 bases      Orientation:
 plus strand

Proteins
for MT1H gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MT1H_HUMAN, P80294 (See protein sequence)
Recommended Name: Metallothionein-1H  
Size: 61 amino acids; 6039 Da
Subunit: Monomer
Secondary accessions: B2RUY6

Explore the universe of human proteins at neXtProt for MT1H: NX_P80294

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P80294

    • MT1H Protein expression data from MOPED and PaxDb:    About this image 
    MT1H Protein Expression
    REFSEQ proteins: NP_005942.1  
    ENSEMBL proteins: 
     ENSP00000330587   ENSP00000457114  

    Human Recombinant Protein Products for MT1H: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MT1H
    OriGene Protein Over-expression Lysate: MT1H
    OriGene Custom Protein Services for MT1H 
    GenScript Custom Purified and Recombinant Proteins Services for MT1H
    Novus Biologicals MT1H Protein
    Novus Biologicals MT1H Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MT1H

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0048471perinuclear region of cytoplasm ISS--

    MT1H for ontologies           About GeneDecksing



    MT1H Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MT1H 
    GenScript Custom Superior Antibodies Services for MT1H
    Search for Antibodies for MT1H at Abcam  
    Uscn Antibodies for MT1H
    Search ThermoFisher Antibodies for MT1H

    Assay Products for MT1H: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MT1H
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MT1H

    Protein Domains /
    Families
    for MT1H gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MT1H for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P80294

    ProtoNet protein and cluster: P80294

    1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT1H_HUMAN, P80294
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
    the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Function
    for MT1H gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT1H_HUMAN, P80294
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
    transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1H:
    metallothionein 1H cluster

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12970870
    GO:0008270zinc ion binding ISS--
    GO:0046872metal ion binding ----
         
    MT1H for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MT1H 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MT1H
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT1H
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MT1H
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1H
    OriGene shRNA RFP: MT1H
    OriGene siRNA: MT1H
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1H
    Sirion Biotech Custom design and validation of potent shRNA sequences against MT1H 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MT1H
    Sirion Biotech Customized adenovirus for overexpression of MT1H 
    Sirion Biotech Customized adenovirus for potent knockdown of MT1H

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1H
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1H (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MT1H (NM_005951)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1H
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1H 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MT1H
    Search LifeMap BioReagents cell lines for MT1H
    Sirion Biotech Customized stable knockdown cell line services for MT1H 
    Sirion Biotech Customized inducible knockdown cell line services for MT1H
    Sirion Biotech Customized stable overexpressing cell line services for MT1H
    Sirion Biotech Customized inducible overexpressing cell line services for MT1H

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1H


    Pathways & Interactions
    for MT1H gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for MT1H):
        Mineral absorption


    MT1H for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1H

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MT1H (P802941, 3 ENSP000003305874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINK7P580621, 3, ENSP000002745654EBI-296567,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    DNAJC1Q96KC83, ENSP000003661794I2D: score=1 STRING: ENSP00000366179
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045926negative regulation of growth ISS--
    GO:0071276cellular response to cadmium ion IEP16827180
    GO:0071294cellular response to zinc ion IEP8119276

    MT1H for ontologies           About GeneDecksing



    Drugs & Compounds
    for MT1H gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT1H for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT1H

    1 HMDB Compound for MT1H    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--
    2 Novoseek chemical compound relationships for MT1H gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 44.8 3 8049263 (1), 16827180 (1), 15952643 (1)
    zinc 18.8 1 10774930 (1)

    Search CenterWatch for drugs/clinical trials and news about MT1H 

    Transcripts
    for MT1H gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MT1H gene: 
    NM_005951.2  

    Unigene Cluster for MT1H:

    Metallothionein 1H
    Hs.438462  [show with all ESTs]
    Unigene Representative Sequence: BI768538
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332374(uc002ejw.3) ENST00000569155

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MT1H
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT1H
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MT1H
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1H
    OriGene shRNA RFP: MT1H
    OriGene siRNA: MT1H
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1H
    Sirion Biotech Custom design and validation of potent shRNA sequences against MT1H 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1H
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1H (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MT1H (NM_005951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1H
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1H 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MT1H
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MT1H
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1H
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1H

    Additional cDNA sequence: 

    BC008408.1 BC059780.1 BC146930.1 BC146934.1 BT007171.1 X64177.1 

    12 DOTS entries:

    DT.100794889  DT.120684806  DT.120684844  DT.218152  DT.95131272  DT.85103384  DT.85102569  DT.100778332 
    DT.416089  DT.456171  DT.87014110  DT.87014218 

    24/139 AceView cDNA sequences (see all 139):

    BX113499 BI821822 CB529368 AJ712480 T29525 AI341945 F30567 T27991 
    F25557 F30476 CD675632 F26333 S68956 CD672936 F27787 BX495641 
    BX955854 BI769333 X76717 AA973227 BM923250 BI762339 BM971621 BI768538 

    GeneLoc Exon Structure


    Expression
    for MT1H gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT1H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    MT1H Expression
    About this image

    MT1H expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MT1H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT1H

    SOURCE GeneReport for Unigene cluster: Hs.438462
        SABiosciences Custom PCR Arrays for MT1H
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MT1H
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MT1H
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1H
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1H
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1H

    Orthologs
    for MT1H gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MT1H gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MT36
    		 --
    		 71(a)
    		 1 → many
    		 GL343675.1(182526-186438)
    zebrafish
    (Danio rerio)    		 Actinopterygii mt26
    		 metallothionein 2
    		 63(a)
    		 1 → many
    		 18(17193795-17195147)


    ENSEMBL Gene Tree for MT1H (if available)
    TreeFam Gene Tree for MT1H (if available) 

    Paralogs
    for MT1H gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT1H gene
    MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT2A2  MT42  MT1M2  
    MT32  MT1A2  
    12 SIMAP similar genes for MT1H using alignment to 2 protein entries:     MT1H_HUMAN (see all proteins):
    MT1A    MT1L    MT1F    MT2A    MT1B    MT1E
    MT1X    MTP    MT1M    MTE    MT1G    MT4

    MT1H for paralogs           About GeneDecksing



    Genomic Variants
    for MT1H gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/70 NCBI SNPs in MT1H are shown (see all 70)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1135576041,2
    		C,F--56703798(+) TGCAAT/CGGACC 2 /T /M mis13Minor allele frequency- C:0.00CSA NA EU 5877
    rs1127100211,2
    		C,F--56703807(+) CCCCAA/GCTGCT 2 N S mis13Minor allele frequency- G:0.01CSA NA EU 5877
    rs1815179421,2
    		--56704035(+) AAGGCC/TGTCCT 1 -- int10--------
    rs20625451,2
    		C,F,A,H--56704125(+) TGGGAA/GGCATT 1 -- int119Minor allele frequency- G:0.20NS WA NA CSA EA 1741
    rs1118225311,2
    		--56704165(+) TTCAGC/GACAGA 1 -- int13Minor allele frequency- G:0.08CSA WA 121
    rs1125506081,2
    		--56704170(+) CACAGA/GAAGTC 1 -- int12Minor allele frequency- G:0.06CSA WA 120
    rs1181140971,2
    		F--56704175(+) AAAGTC/TGAAGT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1114687671,2
    		C--56704176(+) AAGTCG/AAAGTC 1 -- int13Minor allele frequency- A:0.08CSA WA 121
    rs20625461,2
    		C,F,H--56704217(+) GGACTT/AACCTT 1 -- int18Minor allele frequency- A:0.18EA NS NA 1464
    rs1444335791,2
    		C--56704229(+) GGAAT-/ACAAACGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MT1H (56703726 - 56705041 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT1H: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1H
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1H

    Disorders / Diseases
    for MT1H gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MT1H for disorders           About GeneDecksing

    OMIM gene information: 156354    OMIM disorders: --

    14 diseases for MT1H:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    cryoglobulinemia    renal cell carcinoma
    hepatitis c    vasculitis    esophageal carcinoma    esophagitis
    neuropathy    leukemia    breast cancer    hepatitis
    carcinoma    prostatitis


    Export disorders for MT1H gene to outside databases

    Publications
    for MT1H gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT1H gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MT1H)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of six additional human metallothionein genes. (PubMed id 8049263)1, 2, 3, 9 Stennard F.A....West A.K. (1994)
    2. Induction by zinc of specific metallothionein isoforms in human monocytes. (PubMed id 8119276)1, 2, 9 Pauwels M.... Ley M. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning and specific polymerised-chain-reaction amplification of a third charge-separable human metallothionein isoform. (PubMed id 1425708)1, 2 Soumillion A.... de Ley M. (1992)
    5. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1, 3 West A.K....Richards R.I. (1990)
    6. Metallothionein biosynthesis in human RBC precursors. (PubMed id 11093034)1, 9 Rahman M.T....De Ley M. (2000)
    7. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PubMed id 16827180)1, 9 Chang X.L....Zhou Y.F. (2006)
    8. Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PubMed id 10774930)1, 9 Vandeghinste N....De Ley M. (2000)
    9. Genome-wide association study of a quantitative disord ered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (2012)
    10. Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV vire mia. (PubMed id 20551211)1 Raymond A.D....Montaner L.J. (2010)

    External Searches for MT1H gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MT1H gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4496 HGNC: 7400 AceView: MT1_ Ensembl:ENSG00000205358 euGenes: HUgn4496
    ECgene: MT1H Kegg: 4496 H-InvDB: MT1H

    Other Databases showing MT1H gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MT1H gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT1H Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT1H Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MT1H gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MT1H gene:
    Search GeneIP for patents involving MT1H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MT1H gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for MT1H  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1H   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MT1H  
     OriGene Protein Over-expression Lysate for MT1H   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MT1H   OriGene 3'-UTR Clone for MT1H  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1H   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1H  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MT1H   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MT1H   OriGene Custom Protein Services for MT1H  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1H
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1H
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1H
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1H
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1H
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1H
     GenScript Custom Purified and Recombinant Proteins Services for MT1H GenScript cDNA clones with any tag delivered in your preferred vector for MT1H
     GenScript Custom Assay Services for MT1H GenScript Custom Superior Antibodies Services for MT1H
     GenScript Custom overexpressing Cell Line Services for MT1H CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MT1H promoter
     Search Chromatin IP Primers for MT1H
     RT2 qPCR Primer Assay in human, mouse / rat MT1H
     Search GNC Networks for MT1H
     SABiosciences Custom PCR Arrays for MT1H
     Search Tocris compounds for MT1H
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MT1H proteins
     MT1H lysates
     Search for Antibodies for MT1H at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MT1H
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MT1H Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MT1H
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1H
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MT1H
     SwitchGear Promoter luciferase reporter plasmids for MT1H
     Search ThermoFisher Antibodies for MT1H
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1H
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MT1H
    Sirion Biotech Customized:
     stable knockdown cell line services for MT1H
     inducible knockdown cell line services for MT1H
     design and validation of potent shRNA sequences against MT1H
     adenovirus for potent knockdown of MT1H
     adenovirus for overexpression of MT1H
     stable overexpressing cell line services for MT1H
     inducible overexpressing cell line services for MT1H
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MT1H gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4