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Aliases for MT1H Gene

Aliases for MT1H Gene

  • Metallothionein 1H 2 3
  • Metallothionein-IH 3 4
  • Metallothionein-0 3 4
  • MT-1H 3 4
  • MT-IH 3 4
  • MT-0 3 4
  • MT1 3

External Ids for MT1H Gene

Previous HGNC Symbols for MT1H Gene

  • MT1

Previous GeneCards Identifiers for MT1H Gene

  • GC16P047075
  • GC16P056742
  • GC16P056427
  • GC16P056445
  • GC16P055250
  • GC16P055261
  • GC16P056703
  • GC16P042573

Summaries for MT1H Gene

GeneCards Summary for MT1H Gene

MT1H (Metallothionein 1H) is a Protein Coding gene. Among its related pathways are Mineral absorption. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1H Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1H Gene

Genomics for MT1H Gene

Regulatory Elements for MT1H Gene

Genomic Location for MT1H Gene

Chromosome:
16
Start:
56,669,814 bp from pter
End:
56,671,129 bp from pter
Size:
1,316 bases
Orientation:
Plus strand

Genomic View for MT1H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1H Gene

Proteins for MT1H Gene

  • Protein details for MT1H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80294-MT1H_HUMAN
    Recommended name:
    Metallothionein-1H
    Protein Accession:
    P80294
    Secondary Accessions:
    • B2RUY6

    Protein attributes for MT1H Gene

    Size:
    61 amino acids
    Molecular mass:
    6039 Da
    Quaternary structure:
    • Monomer

neXtProt entry for MT1H Gene

Proteomics data for MT1H Gene at MOPED

Post-translational modifications for MT1H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1H Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1H Gene

Domains & Families for MT1H Gene

Gene Families for MT1H Gene

Suggested Antigen Peptide Sequences for MT1H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80294

UniProtKB/Swiss-Prot:

MT1H_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1H: view

Function for MT1H Gene

Molecular function for MT1H Gene

GENATLAS Biochemistry:
metallothionein 1H cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1H: view

Phenotypes for MT1H Gene

GenomeRNAi human phenotypes for MT1H:
genes like me logo Genes that share phenotypes with MT1H: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1H

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT1H Gene

Localization for MT1H Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1H Gene COMPARTMENTS Subcellular localization image for MT1H gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for MT1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1H: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1H Gene

Pathways & Interactions for MT1H Gene

SuperPathways for MT1H Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1H: view

Pathways by source for MT1H Gene

1 KEGG pathway for MT1H Gene

Interacting Proteins for MT1H Gene

Gene Ontology (GO) - Biological Process for MT1H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 8119276
genes like me logo Genes that share ontologies with MT1H: view

No data available for SIGNOR curated interactions for MT1H Gene

Drugs & Compounds for MT1H Gene

(1) Drugs for MT1H Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404

(1) Additional Compounds for MT1H Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1H: view

Transcripts for MT1H Gene

mRNA/cDNA for MT1H Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1H Gene

Metallothionein 1H:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1H

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1H Gene

No ASD Table

Relevant External Links for MT1H Gene

GeneLoc Exon Structure for
MT1H
ECgene alternative splicing isoforms for
MT1H

Expression for MT1H Gene

mRNA expression in normal human tissues for MT1H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT1H Gene

This gene is overexpressed in Liver (x28.6) and Kidney - Cortex (x9.2).

Protein differential expression in normal tissues from HIPED for MT1H Gene

This gene is overexpressed in Fetal Liver (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MT1H Gene



SOURCE GeneReport for Unigene cluster for MT1H Gene Hs.438462

genes like me logo Genes that share expression patterns with MT1H: view

Protein tissue co-expression partners for MT1H Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MT1H Gene

Orthologs for MT1H Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1H 35
  • 99.45 (n)
  • 100 (a)
-- 36
  • 98 (a)
OneToMany
MT1H 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MT1E 36
  • 80 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt2 36
  • 84 (a)
ManyToMany
Species with no ortholog for MT1H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1H Gene

ENSEMBL:
Gene Tree for MT1H (if available)
TreeFam:
Gene Tree for MT1H (if available)

Paralogs for MT1H Gene

Paralogs for MT1H Gene

(12) SIMAP similar genes for MT1H Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MT1H: view

Variants for MT1H Gene

Sequence variations from dbSNP and Humsavar for MT1H Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2062545 -- 56,670,213(+) TGGGA(A/G)GCATT intron-variant
rs2062546 -- 56,670,305(+) GGACT(A/T)ACCTT intron-variant
rs9934181 -- 56,670,526(+) GCGCC(A/G)GCTCC missense, reference
rs9934420 -- 56,670,776(+) AAAAA(G/T)CTGTG intron-variant
rs17850317 -- 56,670,543(+) TGCAA(A/G)AAGTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MT1H Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
dgv480n67 CNV Loss 20364138
nsv827679 CNV Loss 20364138
nsv827682 CNV Gain 20364138

Variation tolerance for MT1H Gene

Residual Variation Intolerance Score: 84.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1H Gene

HapMap Linkage Disequilibrium report
MT1H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1H Gene

Disorders for MT1H Gene

Relevant External Links for MT1H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1H
genes like me logo Genes that share disorders with MT1H: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1H Gene

Publications for MT1H Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 23 67
  2. Basal and metal-induced expression of metallothionein isoform 1 and 2 genes in the RWPE-1 human prostate epithelial cell line. (PMID: 17590860) Albrecht A.L. … Garrett S.H. (J Appl Toxicol 2008) 23 67
  3. [A study on differentially expressed genes in hepatic stellate cells treated with transforming growth factor beta 1 using cDNA microarray technique]. (PMID: 18983772) Xiao L. … Li Y. (Zhonghua Gan Zang Bing Za Zhi 2008) 23 67
  4. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. (PMID: 18992145) Choi K.H. … Webster M.J. (BMC Psychiatry 2008) 23 67
  5. Functional analysis of the transcription repressor PLU-1/JARID1B. (PMID: 17709396) Scibetta A.G. … Taylor-Papadimitriou J. (Mol. Cell. Biol. 2007) 23 67

Products for MT1H Gene

Sources for MT1H Gene

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