Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1G Gene

protein-coding   GIFtS: 48
GCID: GC16M056700

Metallothionein 1G


(Previous symbol: MT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Metallothionein 1G1 2     metallothionein-1G2
MT11 2     metallothionein-1K2
Metallothionein 1K1 2     metallothionein-IG2
MT-1G2 3     MT1M3
MT-1K2 3     Metallothionein-1K3
MT-IG2 3     Metallothionein-IG3
MT1K2 3     

External Ids:    HGNC: 73991   Entrez Gene: 44952   Ensembl: ENSG000001251447   OMIM: 1563535   UniProtKB: P136403   

Export aliases for MT1G gene to outside databases

Previous GC identifers: GC16M047084 GC16M056752 GC16M056435 GC16M056476 GC16M055258 GC16M042570


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MT1G Gene: 
MT1G (metallothionein 1G) is a protein-coding gene. Diseases associated with MT1G include clear cell renal cell carcinoma, and papillary thyroid carcinoma. GO annotations related to this gene include protein binding and zinc ion binding. An important paralog of this gene is MT1E.

UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1G (Metallothionein 1G) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1G gene promoter:
         STAT5B   STAT1   Sp1   STAT4   STAT1beta   STAT1alpha   STAT2   STAT3   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT1G promoter sequence
   Search SABiosciences Chromatin IP Primers for MT1G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

MT1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1G gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M056700:  view genomic region     (about GC identifiers)

Start:
56,700,643 bp from pter      End:
56,701,977 bp from pter
Size:
1,335 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640 (See protein sequence)
Recommended Name: Metallothionein-1G  
Size: 62 amino acids; 6141 Da
Subunit: Monomer
Secondary accessions: P80296
Alternative splicing: 2 isoforms:  P13640-1   P13640-2   

Explore the universe of human proteins at neXtProt for MT1G: NX_P13640

Explore proteomics data for MT1G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13640

  • MT1G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MT1G Protein Expression
    REFSEQ proteins: NP_005941.1  
    ENSEMBL proteins: 
     ENSP00000391397   ENSP00000456675   ENSP00000369139   ENSP00000456835  

    Human Recombinant Protein Products for MT1G: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MT1G
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MT1G
    GenScript Custom Purified and Recombinant Proteins Services for MT1G
    Novus Biologicals MT1G Protein
    Novus Biologicals MT1G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MT1G 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15735762
    GO:0005737cytoplasm IDA3403543
    GO:0048471perinuclear region of cytoplasm IDA15735762

    MT1G for ontologies           About GeneDecksing



    MT1G Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MT1G
    GenScript Custom Superior Antibodies Services for MT1G
    Search for Antibodies for MT1G at Abcam
    Cloud-Clone Corp. Antibodies for MT1G 
    Search ThermoFisher Antibodies for MT1G
    Search LSBio for Antibodies for MT1G 

    Assay Products for MT1G: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MT1G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MT1G
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MT1G 
    Cloud-Clone Corp. CLIAs for MT1G


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P13640

    ProtoNet protein and cluster: P13640

    UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    MT1G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT1G_HUMAN, P13640
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1G:
    metallothionein 1G cluster

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12646258
    GO:0008270zinc ion binding IDA8119276
    GO:0046872metal ion binding ----
         
    MT1G for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MT1G 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MT1G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT1G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT1G 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT1G
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MT1G
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MT1G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MT1G
    Sirion Biotech Customized adenovirus for overexpression of MT1G

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MT1G (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MT1G (NM_005950)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1G
    Sirion Biotech Customized lentivirus for stable overexpression of MT1G 
                         Customized lentivirus expression plasmids for stable overexpression of MT1G 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MT1G
    Search LifeMap BioReagents cell lines for MT1G
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MT1G About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MT1G):
        Mineral absorption


    MT1G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MT1G

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MT1G (P136401, 3 ENSP000003913974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINK7P580621, 3, ENSP000002745654EBI-1182473,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030224monocyte differentiation NAS8119276
    GO:0035924cellular response to vascular endothelial growth factor stimulus IEP15735762
    GO:0042117monocyte activation NAS8119276
    GO:0045926negative regulation of growth IDA18332874
    GO:0071276cellular response to cadmium ion IEP16827180

    MT1G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT1G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT1G

    1 HMDB Compound for MT1G    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--

    4 Novoseek inferred chemical compound relationships for MT1G gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 67.6 10 19330122 (3), 8171441 (1), 16827180 (1), 17485079 (1) (see all 7)
    zinc 51.7 11 14998373 (2), 10774930 (1), 1690731 (1), 15894685 (1)
    copper 11.5 2 1690731 (1)
    calcium 0 1 19356627 (1)

    Search CenterWatch for drugs/clinical trials and news about MT1G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MT1G gene: 
    NM_005950.1  

    Unigene Cluster for MT1G:

    Metallothionein 1G
    Hs.433391  [show with all ESTs]
    Unigene Representative Sequence: BC048334
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444837(uc002eju.1) ENST00000569500 ENST00000379811(uc002ejv.1)
    ENST00000568675
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT1G
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MT1G
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MT1G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1G
    Clone
    Products:
         
    OriGene clones in human, mouse for MT1G (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MT1G (NM_005950)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1G
    Sirion Biotech Customized lentivirus for stable overexpression of MT1G 
                         Customized lentivirus expression plasmids for stable overexpression of MT1G 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MT1G
    OriGene qSTAR qPCR primer pairs in human, mouse for MT1G
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MT1G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1G

    Additional mRNA sequence: 

    BC020757.1 BC048334.1 

    13 DOTS entries:

    DT.218152  DT.85102569  DT.416087  DT.85103384  DT.100794889  DT.95131272  DT.120684773  DT.120684946 
    DT.120684906  DT.100794887  DT.87014110  DT.87014218  DT.100059597 

    24/162 AceView cDNA sequences (see all 162):

    AW953868 BC048334 BM817643 BX092376 S68954 BC035287 R29068 CF456768 
    AW963354 BI760266 BM923855 AI126783 BM702890 AA331295 AL531430 BX405625 
    BI761514 BX422558 W79895 AI110774 CA309973 BI761982 AW025974 W03216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT1G expression in normal human tissues (normalized intensities)      MT1G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT1G Expression
    About this image


    MT1G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Line H9 (WA09)
             H1-GFP   
     
     Liver (Hepatobiliary System)
             Human Hepatocyte (HH)   
     
     Peripheral Nervous System (Nervous System)
             Human Perineurial Cells (HPC)   
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Eye (Sensory Organs)
             Human Iris Pigment Epithelial Cells (HIPEpiC)   

    See MT1G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT1G

    SOURCE GeneReport for Unigene cluster: Hs.433391
        SABiosciences Custom PCR Arrays for MT1G
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MT1G
    OriGene qSTAR qPCR primer pairs in human, mouse for MT1G
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MT1G
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1G
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MT1G gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    Metallothionein
    79(a)
    77(a)
    possible ortholog
    possible ortholog
    1(447543240-447544299)
    1(447553987-447554919)
    zebrafish
    (Danio rerio)
    Actinopterygii mt26
    metallothionein 2
    60(a)
    1 → many
    18(17193795-17195147)


    ENSEMBL Gene Tree for MT1G (if available)
    TreeFam Gene Tree for MT1G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT1G gene
    MT1E2  MT1F2  MT1X2  MT1B2  MT2A2  MT1HL12  MT1M2  MT1H2  
    MT1A2  
    13 SIMAP similar genes for MT1G using alignment to 3 protein entries:     MT1G_HUMAN (see all proteins):
    MT1X    MTE    MT1M    MT1F    MT1E    MT2A
    MT4    MT1A    MT1L    MT1H    MT1B    MT1HL1
    MTP

    MT1G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MT1G:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv481n67CNV Loss20364138
    nsv827679CNV Loss20364138
    dgv480n67CNV Loss20364138
    nsv906720CNV Loss21882294
    nsv827682CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MT1G
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 156353    OMIM disorders: --

    20/22 diseases for MT1G (see all 22):    About MalaCards
    clear cell renal cell carcinoma    papillary thyroid carcinoma    esophageal squamous cell carcinoma    keloids
    renal cell carcinoma    hepatoblastoma    hepatocellular carcinoma    acute lymphoblastic leukemia
    thyroid cancer    esophagitis    lymphoblastic leukemia    thyroiditis
    squamous cell carcinoma    pancreatic cancer    lung cancer    gastric cancer
    pancreatitis    endotheliitis    prostate cancer    melanoma


    MT1G for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MT1G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 22.1 2 19639168 (1), 1690731 (1)
    tumors 0 5 19639168 (2), 15894685 (2)


    Export disorders for MT1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT1G gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with MT1G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. (PubMed id 3403543)1, 2, 3 Foster R.... Gedamu L. (1988)
    2. Induction by zinc of specific metallothionein isoforms in human monocytes. (PubMed id 8119276)1, 2, 9 Pauwels M.... Ley M. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structure and expression of the human metallothionein genes. (PubMed id 2444457)1, 2 Gedamu L.... Shworak N.W. (1987)
    5. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (1984)
    6. Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of doub le combination array analysis. (PubMed id 19639168)1, 9 Kanda M....Nakao A. (2009)
    7. Low-Dose Cadmium Exposure Reduces Human Prostate Cell Transformation in Culture and Up-Regulates Metallothionein and MT-1G mRNA. (PubMed id 19330122)1, 9 Gaddipati J.P....Jonas W.B. (2003)
    8. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. (PubMed id 15735762)1, 9 Joshi B....Chellappan S. (2005)
    9. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PubMed id 16827180)1, 9 Chang X.L....Zhou Y.F. (2006)
    10. Genome-wide association study of a quantitative disord ered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4495 HGNC: 7399 AceView: MT1G Ensembl:ENSG00000125144 euGenes: HUgn4495
    ECgene: MT1G Kegg: 4495 H-InvDB: MT1G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT1G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MT1G gene:
    Search GeneIP for patents involving MT1G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MT1G  
     OriGene qPCR primer pairs and template standards for MT1G   OriGene Protein Over-expression Lysate for MT1G  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MT1G  
     OriGene qSTAR qPCR primer pairs in human, mouse for MT1G   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MT1G   OriGene Custom Protein Services for MT1G  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1G
     QIAGEN SeqTarget long-range PCR primers for resequencing MT1G
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1G
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1G
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1G
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1G
     GenScript Custom Purified and Recombinant Proteins Services for MT1G GenScript cDNA clones with any tag delivered in your preferred vector for MT1G
     GenScript Custom Assay Services for MT1G GenScript Custom Superior Antibodies Services for MT1G
     GenScript Custom overexpressing Cell Line Services for MT1G CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MT1G promoter
     Search Chromatin IP Primers for MT1G
     RT2 qPCR Primer Assay in human, mouse / rat MT1G
     GNC Network for MT1G
     SABiosciences Custom PCR Arrays for MT1G
     Search Tocris compounds for MT1G
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MT1G proteins
     MT1G lysates
     Search for Antibodies for MT1G at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MT1G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MT1G
     Antibodies for MT1G
     ELISAs for MT1G
     CLIAs for MT1G
     Search LifeMap BioReagents cell lines for MT1G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1G
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MT1G
     SwitchGear Promoter luciferase reporter plasmids for MT1G
     Search ThermoFisher Antibodies for MT1G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1G
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MT1G
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MT1G
    Customized:
     lentivirus for stable overexpression of MT1G
     lentivirus expression plasmids for stable overexpression of MT1G
     adenovirus for overexpression of MT1G
     Search LSBio for Antibodies for MT1G
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MT1G gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4