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Aliases for MT1G Gene

Aliases for MT1G Gene

  • Metallothionein 1G 2 3
  • Metallothionein 1K 2 3
  • Metallothionein-1K 3 4
  • Metallothionein-IG 3 4
  • MT-1G 3 4
  • MT-1K 3 4
  • MT-IG 3 4
  • MT1K 3 4
  • Metallothionein-1G 3
  • MT1M 4
  • MT1 3

External Ids for MT1G Gene

Previous Symbols for MT1G Gene

  • MT1

Summaries for MT1G Gene

GeneCards Summary for MT1G Gene

MT1G (Metallothionein 1G) is a Protein Coding gene. Diseases associated with MT1G include clear cell renal cell carcinoma and renal cell carcinoma. Among its related pathways are Mineral absorption. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1G Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1G Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1G Gene

Genomics for MT1G Gene

Genomic Location for MT1G Gene

Start:
56,666,731 bp from pter
End:
56,668,065 bp from pter
Size:
1,335 bases
Orientation:
Minus strand

Genomic View for MT1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1G Gene

Regulatory Elements for MT1G Gene

Proteins for MT1G Gene

  • Protein details for MT1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13640-MT1G_HUMAN
    Recommended name:
    Metallothionein-1G
    Protein Accession:
    P13640
    Secondary Accessions:
    • P80296

    Protein attributes for MT1G Gene

    Size:
    62 amino acids
    Molecular mass:
    6141 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for MT1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MT1G Gene

Proteomics data for MT1G Gene at MOPED

Post-translational modifications for MT1G Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44

Other Protein References for MT1G Gene

No data available for DME Specific Peptides for MT1G Gene

Domains for MT1G Gene

Gene Families for MT1G Gene

HGNC:
  • MT :Metallothioneins

Suggested Antigen Peptide Sequences for MT1G Gene

Graphical View of Domain Structure for InterPro Entry

P13640

UniProtKB/Swiss-Prot:

MT1G_HUMAN
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines:
    • P13640
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.:
    • P13640
genes like me logo Genes that share domains with MT1G: view

Function for MT1G Gene

Molecular function for MT1G Gene

GENATLAS Biochemistry: metallothionein 1G cluster
UniProtKB/Swiss-Prot Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008270 zinc ion binding IDA 8119276
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1G: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MT1G Gene

Localization for MT1G Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1G Gene COMPARTMENTS Subcellular localization image for MT1G gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15735762
GO:0005737 cytoplasm IDA 3403543
GO:0048471 perinuclear region of cytoplasm IDA 15735762
genes like me logo Genes that share ontologies with MT1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1G Gene

Pathways for MT1G Gene

SuperPathways for MT1G Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1G: view

Pathways by source for MT1G Gene

1 KEGG pathway for MT1G Gene

Interacting Proteins for MT1G Gene

Gene Ontology (GO) - Biological Process for MT1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030224 monocyte differentiation NAS 8119276
GO:0035924 cellular response to vascular endothelial growth factor stimulus IEP 15735762
GO:0042117 monocyte activation NAS 8119276
GO:0045926 negative regulation of growth IDA 18332874
GO:0071276 cellular response to cadmium ion IEP 16827180
genes like me logo Genes that share ontologies with MT1G: view

Compounds for MT1G Gene

(1) HMDB Compounds for MT1G Gene

Compound Synonyms Cas Number PubMed IDs
Cadmium
  • Cd
7440-43-9

(4) Novoseek inferred chemical compound relationships for MT1G Gene

Compound -log(P) Hits PubMed IDs
cadmium 67.6 9
zinc 51.7 5
copper 11.5 1
calcium 0 1
genes like me logo Genes that share compounds with MT1G: view

Transcripts for MT1G Gene

mRNA/cDNA for MT1G Gene

Unigene Clusters for MT1G Gene

Metallothionein 1G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1G Gene

No ASD Table

Relevant External Links for MT1G Gene

GeneLoc Exon Structure for
MT1G
ECgene alternative splicing isoforms for
MT1G

Expression for MT1G Gene

mRNA expression in normal human tissues for MT1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT1G Gene

This gene is overexpressed in Liver (24.3), Kidney - Cortex (7.1), and Pancreas (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MT1G Gene

SOURCE GeneReport for Unigene cluster for MT1G Gene Hs.433391

genes like me logo Genes that share expressions with MT1G: view

No data available for mRNA Expression by UniProt/SwissProt for MT1G Gene

Orthologs for MT1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
MT1G 36
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MT2 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MT2A 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mt1 36
  • 82 (a)
ManyToMany
Species with no ortholog for MT1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1G Gene

ENSEMBL:
Gene Tree for MT1G (if available)
TreeFam:
Gene Tree for MT1G (if available)

Paralogs for MT1G Gene

Paralogs for MT1G Gene

Selected SIMAP similar genes for MT1G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MT1G: view

Variants for MT1G Gene

Sequence variations from dbSNP and Humsavar for MT1G Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12315 -- 56,666,810(-) TTTTG(A/C)TACAA utr-variant-3-prime
rs1058819 -- 56,666,818(-) TTTTT(G/T)TTTTT utr-variant-3-prime
rs2298846 -- 56,667,403(-) CACCG(C/T)TCACT intron-variant
rs2298847 -- 56,667,382(-) CTTCT(A/T)GCAGG splice-acceptor-variant, intron-variant
rs4432266 -- 56,666,771(+) ATTTC(A/G)CAGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MT1G Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
dgv480n67 CNV Loss 20364138
nsv827679 CNV Loss 20364138
dgv481n67 CNV Loss 20364138
nsv827682 CNV Gain 20364138

Relevant External Links for MT1G Gene

HapMap Linkage Disequilibrium report
MT1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1G Gene

Disorders for MT1G Gene

(2) Novoseek inferred disease relationships for MT1G Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 22.1 2
tumors 0 4
genes like me logo Genes that share disorders with MT1G: view

No data available for UniProtKB/Swiss-Prot for MT1G Gene

Publications for MT1G Gene

  1. Induction by zinc of specific metallothionein isoforms in human monocytes. (PMID: 8119276) Pauwels M. … Ley M. (Eur. J. Biochem. 1994) 3 4 23
  2. Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. (PMID: 3403543) Foster R. … Gedamu L. (J. Biol. Chem. 1988) 2 3 4
  3. Human metallothionein genes are clustered on chromosome 16. (PMID: 6089206) Karin M. … Shows T.B. (Proc. Natl. Acad. Sci. U.S.A. 1984) 2 3
  4. Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis. (PMID: 19639168) Kanda M. … Nakao A. (Int. J. Oncol. 2009) 3 23
  5. Low-Dose Cadmium Exposure Reduces Human Prostate Cell Transformation in Culture and Up-Regulates Metallothionein and MT-1G mRNA. (PMID: 19330122) Gaddipati J.P. … Jonas W.B. (Nonlinearity Biol Toxicol Med 2003) 3 23

Products for MT1G Gene

Sources for MT1G Gene

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