MT1F Gene
protein-coding GIFtS : 53
GCID: GC16 P056691
metallothionein 1F (Previous symbol: MT1 )
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Aliasesfor MT1F gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Metallothionein 1F 1 2 Metallothionein 1F (Functional)2 MT11 2 Metallothionein-1F1 MT-1F2 3 Metallothionein-IF3 MT-IF2 3 Metallothionein-IF3
Export aliases for MT1F gene to outside databases Previous GC identifers: GC16U990041 GC16P056426 GC16P056444 GC16P056449 GC16P055249 GC16P042561
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Summariesfor MT1F gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MT1F_HUMAN, P04733 Function : Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids Gene Wiki entry for MT1F
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Genomic Viewsfor MT1F gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MT1F gene promoter: HEN1 Sp1 USF-1 Zic3 E47 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for MT1F Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MT1F
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13 MT1F Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P056691: view genomic region
(about GC identifiers )
Start:
56,691,606 bp from pter
End:
56,694,610 bp from pter
Size:
3,005 bases
Orientation:
plus strand
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Proteinsfor MT1F gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MT1F_HUMAN, P04733 (See
protein sequence )Recommended Name: Metallothionein-1F Size : 61 amino acids; 6086 Da
Subunit : Monomer
Sequence caution : Sequence=AAF23355.1; Type=Erroneous initiation;
Secondary accessions : Q9UI97Explore the universe of human proteins at neXtProt for MT1F: NX_P04733 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P04733 MT1F Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_005940.1 ENSEMBL proteins: ENSP00000334872 ENSP00000456462 ENSP00000378009 Human Recombinant Protein Products for MT1F: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
MT1F for ontologies About GeneDecksing MT1F Antibody Products: Assay Products for MT1F:
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Protein
Domains / Familiesfor MT1F gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MT1F for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P04733 ProtoNet protein and cluster: P04733
1 Blocks protein family : IPB002400 Growth factor cystine knot superfamily signature UniProtKB/Swiss-Prot: MT1F_HUMAN, P04733 Domain : Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A ofthe alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines Similarity : Belongs to the metallothionein superfamily. Type 1 family
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Functionfor MT1F gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: MT1F_HUMAN, P04733 Function : Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids
Genatlas biochemistry entry for MT1F : metallothionein 1F cluster Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
MT1F for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for MT1F :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MT1F OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MT1FOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MT1F (NM_005949 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT1F Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MT1F
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Pathways & Interactionsfor MT1F gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Mineral absorption
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for MT1F) :
MT1F for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1F STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for MT1F (P04733 3 ENSP00000334872 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
MT1F for ontologies About GeneDecksing
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Drugs & Compoundsfor MT1F gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MT1F for compounds About GeneDecksing Browse Tocris compounds for MT1F 1 HMDB Compound for MT1F About this table 5 Novoseek chemical compound relationships for MT1F gene About this table
Search CenterWatch for drugs/clinical trials and news about MT1F
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Transcriptsfor MT1F gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MT1F gene: NM_005949.3 Unigene Cluster for MT1F:
Metallothionein 1F Hs.513626 [show with all ESTs ] Unigene Representative Sequence: BC108722 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000334350 (uc002ejt.3 ) ENST00000564295 ENST00000568475 ENST00000567672 ENST00000394501 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MT1F OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MT1FOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MT1F (NM_005949 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT1F Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MT1F
Additional cDNA sequence: BC029453.1 BC108722.1
9 DOTS entries : DT.100035828 DT.87016354
DT.416087 DT.120684783 DT.120685055 DT.416089 DT.120684767 DT.91697702 DT.95216529 24/139 AceView cDNA sequences (see all 139 ):
BX113499 CD672936 CB529368 AJ712480 F25557 F30567 T29525 F30476 S68956 AI341945 F26333 T27991 CD675632 F27787 BI821822 AI343762 BM920306 BQ428187 BM925369 AA973675 NM_005952 BC053882 AA323862 BM726910 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for MT1F About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 SP1 :                       SP2 :       -                 SP3 :                       SP4 :             -          
ECgene alternative splicing isoforms for MT1F
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Expression for MT1F gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MT1F expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACAAACCTGAbout this image MT1F expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See MT1F Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MT1F SOURCE GeneReport for Unigene cluster: Hs.513626 SABiosciences Expression via Pathway-Focused PCR Array including MT1F : Cardiotoxicity in human mouse rat
Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat MT1F QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MT1F QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MT1F
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Orthologsfor MT1F gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MT1F gene from 2/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for MT1F (if available)TreeFam Gene Tree for MT1F (if available)
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Paralogsfor MT1F gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MT1F gene MT1G 2 MT1E 2 MT1X 2 MT1B 2 MT2A 2 MT4 2 MT1M 2 MT3 2 MT1H 2 MT1A 2 14 SIMAP similar genes for MT1F using alignment to 3 protein entries: MT1F_HUMAN (see all proteins ):MT1A MT1L MT1H MT1B MTP MT1J MTE MT1M MT1G MT1X MT1E MT2A MT3 MT4
MT1F for paralogs About GeneDecksing
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Genomic Variantsfor MT1F gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MT1F (56691606 - 56694610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MT1F: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MT1F
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Disorders
/ Diseasesfor MT1F gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MT1F for disorders About GeneDecksing
OMIM gene information: 156352
OMIM disorders : --11 diseases for MT1F : About MalaCards renal cell carcinoma keloids breast cancer hepatocellular carcinoma pancreatic cancer breast carcinoma carcinoma pancreatitis hepatitis prostatitis neuronitis 2 Novoseek disease relationships for MT1F gene About this table
Export disorders for MT1F gene to outside databases
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Publicationsfor MT1F gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MT1F gene, integrated from 9 sources (see all 51 ): (articles sorted by number of sources associating them with MT1F) Utopia : connect your pdf to the dynamic world of online information
Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. (PubMed id 2581970) 1 , 2 , 3 Schmidt C.J....Hamer D.H. (1985) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Structure and expression of the human metallothionein genes. (PubMed id 2444457) 1 , 2 Gedamu L.... Shworak N.W. (1987) Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. (PubMed id 3023827) 1 , 2 Varshney U.... Gedamu L. (1986) Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206) 1 , 3 Karin M....Shows T.B. (1984) Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. (PubMed id 9831543) 1 , 9 Garrett S.H....Sens D.A. (1998) Significance of metallothionein expression in breast myoepithelial cells. (PubMed id 11291768) 1 , 9 Jin R....Dheen T. (2001) Fine ambient particles induce oxidative stress and me tal binding genes in human alveolar macrophages. (PubMed id 19251948) 1 , 9 Huang Y.C....Yang I.V. (2009) Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PubMed id 10774930) 1 , 9 Vandeghinste N....De Ley M. (2000) Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. (PubMed id 8619255) 1 , 9 Mididoddi S....Sens D.A. (1996)
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External Searches for MT1F gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MT1F gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MT1F gene
(According to HUGE )
About This Section --
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Specialized Databases showing MT1F gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MT1F Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MT1F gene: Search GeneIP for patents involving MT1F GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MT1F gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MT1F OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MT1F Browse OriGene genome-wide validated SYBR primer pairs OriGene Protein Over-expression Lysate for MT1F Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MT1F OriGene 3'-UTR Clone for MT1F OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MT1F OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MT1F Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MT1F OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MT1F OriGene Custom Protein Services for MT1F OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1F QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MT1F QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MT1F QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MT1F QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MT1F QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MT1F
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MT1F Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MT1F
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Aliases for MT1F
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Disorders / Diseases for MT1F
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Expression for MT1F
Function for MT1F
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