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Aliases for MT1F Gene

Aliases for MT1F Gene

  • Metallothionein 1F 2 3
  • Metallothionein-IF 3 4
  • MT-1F 3 4
  • MT-IF 3 4
  • Metallothionein 1F (Functional) 3
  • Metallothionein-1F 3
  • MT1 3

External Ids for MT1F Gene

Previous HGNC Symbols for MT1F Gene

  • MT1

Previous GeneCards Identifiers for MT1F Gene

  • GC16U990041
  • GC16P056426
  • GC16P056444
  • GC16P056449
  • GC16P055249
  • GC16P056691
  • GC16P042561

Summaries for MT1F Gene

GeneCards Summary for MT1F Gene

MT1F (Metallothionein 1F) is a Protein Coding gene. Among its related pathways are Mineral absorption. GO annotations related to this gene include copper ion binding and cadmium ion binding. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1F Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1F Gene

Genomics for MT1F Gene

Regulatory Elements for MT1F Gene

Genomic Location for MT1F Gene

Start:
56,657,694 bp from pter
End:
56,660,698 bp from pter
Size:
3,005 bases
Orientation:
Plus strand

Genomic View for MT1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1F Gene

Proteins for MT1F Gene

  • Protein details for MT1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04733-MT1F_HUMAN
    Recommended name:
    Metallothionein-1F
    Protein Accession:
    P04733
    Secondary Accessions:
    • Q9UI97

    Protein attributes for MT1F Gene

    Size:
    61 amino acids
    Molecular mass:
    6086 Da
    Quaternary structure:
    • Monomer
    SequenceCaution:
    • Sequence=AAF23355.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MT1F Gene

Proteomics data for MT1F Gene at MOPED

Post-translational modifications for MT1F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1F Gene

Domains for MT1F Gene

Gene Families for MT1F Gene

HGNC:
  • MT :Metallothioneins

Suggested Antigen Peptide Sequences for MT1F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04733

UniProtKB/Swiss-Prot:

MT1F_HUMAN :
  • P04733
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1F: view

Function for MT1F Gene

Molecular function for MT1F Gene

GENATLAS Biochemistry: metallothionein 1F cluster
UniProtKB/Swiss-Prot Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1F: view

Phenotypes for MT1F Gene

GenomeRNAi human phenotypes for MT1F:
genes like me logo Genes that share phenotypes with MT1F: view

miRNA for MT1F Gene

miRTarBase miRNAs that target MT1F

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MT1F Gene

Localization for MT1F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1F Gene COMPARTMENTS Subcellular localization image for MT1F gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MT1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8619255
GO:0005737 cytoplasm IDA 8619255
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1F Gene

Pathways for MT1F Gene

SuperPathways for MT1F Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1F: view

Pathways by source for MT1F Gene

1 KEGG pathway for MT1F Gene

Interacting Proteins for MT1F Gene

Gene Ontology (GO) - Biological Process for MT1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion ISS --
genes like me logo Genes that share ontologies with MT1F: view

Compounds for MT1F Gene

(1) HMDB Compounds for MT1F Gene

Compound Synonyms Cas Number PubMed IDs
Cadmium
  • Cd
7440-43-9

(5) Novoseek inferred chemical compound relationships for MT1F Gene

Compound -log(P) Hits PubMed IDs
cadmium 69.5 5
melatonin 43.8 5
zinc 26.9 2
copper 21.9 3
estrogen 12.4 2
genes like me logo Genes that share compounds with MT1F: view

Transcripts for MT1F Gene

mRNA/cDNA for MT1F Gene

Unigene Clusters for MT1F Gene

Metallothionein 1F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1F Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for MT1F Gene

GeneLoc Exon Structure for
MT1F
ECgene alternative splicing isoforms for
MT1F

Expression for MT1F Gene

mRNA expression in normal human tissues for MT1F Gene

mRNA differential expression in normal tissues according to GTEx for MT1F Gene

This gene is overexpressed in Liver (16.1), Thyroid (4.5), and Kidney - Cortex (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT1F Gene

SOURCE GeneReport for Unigene cluster for MT1F Gene Hs.513626

genes like me logo Genes that share expressions with MT1F: view

No data available for mRNA Expression by UniProt/SwissProt for MT1F Gene

Orthologs for MT1F Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MT1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1F 35
  • 96.72 (n)
  • 98.36 (a)
MT1F 36
  • 97 (a)
OneToOne
Species with no ortholog for MT1F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1F Gene

ENSEMBL:
Gene Tree for MT1F (if available)
TreeFam:
Gene Tree for MT1F (if available)

Paralogs for MT1F Gene

Paralogs for MT1F Gene

Selected SIMAP similar genes for MT1F Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MT1F: view

Variants for MT1F Gene

Sequence variations from dbSNP and Humsavar for MT1F Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs924469 -- 56,655,994(+) GTCTA(C/T)AATAT upstream-variant-2KB
rs1875234 -- 56,659,541(+) GCACA(G/T)AAACT intron-variant, downstream-variant-500B
rs2291956 -- 56,658,306(+) TGCTC(C/T)ACGTC intron-variant
rs2291957 -- 56,659,349(+) ACTGG(G/T)GTGGG intron-variant, downstream-variant-500B
rs4464073 -- 56,656,126(+) AAACA(C/T)GGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1F Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294

Relevant External Links for MT1F Gene

HapMap Linkage Disequilibrium report
MT1F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1F Gene

Disorders for MT1F Gene

(2) Novoseek inferred disease relationships for MT1F Gene

Disease -log(P) Hits PubMed IDs
breast cancer 32 9
tumors 0 3

Relevant External Links for MT1F

Genetic Association Database (GAD)
MT1F
genes like me logo Genes that share disorders with MT1F: view

No data available for UniProtKB/Swiss-Prot for MT1F Gene

Publications for MT1F Gene

  1. Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. (PMID: 2581970) Schmidt C.J. … Hamer D.H. (J. Biol. Chem. 1985) 2 3 4
  2. Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. (PMID: 3023827) Varshney U. … Gedamu L. (Mol. Cell. Biol. 1986) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human metallothionein genes are clustered on chromosome 16. (PMID: 6089206) Karin M. … Shows T.B. (Proc. Natl. Acad. Sci. U.S.A. 1984) 2 3
  5. Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. (PMID: 8619255) Mididoddi S. … Sens D.A. (Toxicol. Lett. 1996) 3 23

Products for MT1F Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cardiotoxicity in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1F
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1F
    • Block miRNA regulation of MT1F using miScript Target Protectors

    Sources for MT1F Gene

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