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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1F Gene

protein-coding   GIFtS: 54
GCID: GC16P056691

Metallothionein 1F


(Previous symbol: MT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Metallothionein 1F1 2     Metallothionein 1F (Functional)2
MT11 2     metallothionein-1F2
MT-1F2 3     metallothionein-IF2
MT-IF2 3     Metallothionein-IF3

External Ids:    HGNC: 73981   Entrez Gene: 44942   Ensembl: ENSG000001984177   OMIM: 1563525   UniProtKB: P047333   

Export aliases for MT1F gene to outside databases

Previous GC identifers: GC16U990041 GC16P056426 GC16P056444 GC16P056449 GC16P055249 GC16P042561


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MT1F Gene: 
MT1F (metallothionein 1F) is a protein-coding gene. Diseases associated with MT1F include keloids, and renal cell carcinoma. GO annotations related to this gene include cadmium ion binding and copper ion binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: MT1F_HUMAN, P04733
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1F gene promoter:
         HEN1   Sp1   USF-1   Zic3   E47   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT1F promoter sequence
   Search SABiosciences Chromatin IP Primers for MT1F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1F gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056691:  view genomic region     (about GC identifiers)

Start:
56,691,606 bp from pter      End:
56,694,610 bp from pter
Size:
3,005 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MT1F_HUMAN, P04733 (See protein sequence)
Recommended Name: Metallothionein-1F  
Size: 61 amino acids; 6086 Da
Subunit: Monomer
Sequence caution: Sequence=AAF23355.1; Type=Erroneous initiation;
Secondary accessions: Q9UI97

Explore the universe of human proteins at neXtProt for MT1F: NX_P04733

Explore proteomics data for MT1F at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04733

  • MT1F Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MT1F Protein Expression
    REFSEQ proteins: NP_005940.1  
    ENSEMBL proteins: 
     ENSP00000334872   ENSP00000456462   ENSP00000378009  

    Human Recombinant Protein Products for MT1F: 
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    Novus Biologicals MT1F Protein
    Novus Biologicals MT1F Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MT1F 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8619255
    GO:0005737cytoplasm IDA8619255
    GO:0048471perinuclear region of cytoplasm ISS--

    MT1F for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for MT1F 
    Cloud-Clone Corp. CLIAs for MT1F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P04733

    ProtoNet protein and cluster: P04733

    1 Blocks protein domain: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT1F_HUMAN, P04733
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    MT1F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT1F_HUMAN, P04733
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1F:
    metallothionein 1F cluster

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding NAS--
    GO:0008270zinc ion binding NAS--
    GO:0046870cadmium ion binding NAS--
    GO:0046872metal ion binding ----
         
    MT1F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MT1F:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MT1F 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MT1F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT1F 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT1F 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMT1F 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of MT1F 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1F


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MT1F About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MT1F):
        Mineral absorption


    MT1F for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1F

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MT1F (P047333 ENSP000003348724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045926negative regulation of growth ISS--
    GO:0071276cellular response to cadmium ion IEP16827180
    GO:0071294cellular response to zinc ion ISS--

    MT1F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT1F for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT1F

    1 HMDB Compound for MT1F    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--

    5 Novoseek inferred chemical compound relationships for MT1F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 69.5 5 18755257 (1), 8171441 (1), 16827180 (1), 1690731 (1) (see all 5)
    melatonin 43.8 7 11888668 (2), 18755257 (1), 15073572 (1), 12960008 (1)
    zinc 26.9 3 10774930 (1), 1690731 (1)
    copper 21.9 3 9831543 (2), 1690731 (1)
    estrogen 12.4 3 15188022 (1), 15073572 (1)

    Search CenterWatch for drugs/clinical trials and news about MT1F

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MT1F gene: 
    NM_005949.3  

    Unigene Cluster for MT1F:

    Metallothionein 1F
    Hs.513626  [show with all ESTs]
    Unigene Representative Sequence: BC108722
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334350(uc002ejt.3) ENST00000564295 ENST00000568475 ENST00000567672
    ENST00000394501
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MT1F
    SwitchGear 3'UTR luciferase reporter plasmidMT1F 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1F
    Clone
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    GenScript: all cDNA clones in your preferred vector: MT1F (NM_005949)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1F
    Sirion Biotech Customized lentivirus for stable overexpression of MT1F 
                         Customized lentivirus expression plasmids for stable overexpression of MT1F 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MT1F
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MT1F
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1F

    Additional mRNA sequence: 

    BC029453.1 BC108722.1 

    9 DOTS entries:

    DT.100035828  DT.87016354  DT.416087  DT.120684783  DT.120685055  DT.416089  DT.120684767  DT.91697702 
    DT.95216529 

    24/139 AceView cDNA sequences (see all 139):

    F27787 CD675632 BI821822 F26333 F30567 S68956 F30476 T29525 
    T27991 AJ712480 F25557 CB529368 BX113499 AI341945 CD672936 AI358260 
    BQ428187 AA344582 BG927843 BM920306 AI343762 X76717 BM920880 BM694421 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MT1F    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                                  
    SP2:                    -                                             
    SP3:                                                                  
    SP4:                                      -                           


    ECgene alternative splicing isoforms for MT1F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT1F expression in normal human tissues (normalized intensities)      MT1F embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAACCTG
    MT1F Expression
    About this image


    MT1F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor ES-139
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
     
     Ectoderm (Gastrulation Derivatives)
             PureStem ES-210, Ecto-ntu Progenitor
     
     Kidney (Urinary System)
             Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)   

    See MT1F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT1F

    SOURCE GeneReport for Unigene cluster: Hs.513626
        SABiosciences Expression via Pathway-Focused PCR Array including MT1F: 
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MT1F gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii mt21 metallothionein 2 68.93(n)
    67.8(a)
      100174951  NM_001131053.2  NP_001124525.2 
            Species with no ortholog for MT1F

    ENSEMBL Gene Tree for MT1F (if available)
    TreeFam Gene Tree for MT1F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT1F gene
    MT1G2  MT1E2  MT1X2  MT1B2  MT1HL12  MT2A2  MT1M2  MT1H2  
    MT1A2  
    15 SIMAP similar genes for MT1F using alignment to 3 protein entries:     MT1F_HUMAN (see all proteins):
    MT1A    MT1L    MT1H    MT1B    MT1HL1    MTP
    MT1J    MTE    MT1M    MT1G    MT1X    MT1E
    MT2A    MT3    MT4

    MT1F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/126 SNPs in MT1F are shown (see all 126)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9244691,2
    C,F,A,H--56689906(+) GTCTAC/TAATAT 1 -- us2k127Minor allele frequency- T:0.46NS EA NA CSA WA 2907
    rs1929219051,2
    --56689957(+) GGGGAC/TATTTG 1 -- us2k10--------
    rs1852520181,2
    --56689987(+) GCCAGG/TCCTGG 1 -- us2k10--------
    rs1401749541,2
    C--56690001(+) GCCTAA/GCTGTG 1 -- us2k10--------
    rs1138962051,2
    F--56690023(+) TGTCAC/TCTACC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs44640731,2
    C--56690038(+) AAACAC/TGGGTC 1 -- us2k14Minor allele frequency- T:0.23NA WA EA 360
    rs1458664111,2
    --56690039(+) AACACA/GGGTCC 1 -- us2k10--------
    rs1489701471,2
    --56690085(+) ATGTCA/TTCAAC 1 -- us2k10--------
    rs1121157271,2
    C,F--56690096(+) ACAGGG/TTTAAA 1 -- us2k12Minor allele frequency- T:0.04NA 122
    rs757054441,2
    C--56690100(+) GGTTAA/TAAAGC 1 -- us2k14Minor allele frequency- T:0.17NA WA EA 360

    HapMap Linkage Disequilibrium report for MT1F (56691606 - 56694610 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MT1F:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906720CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MT1F
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 156352    OMIM disorders: --

    10 diseases for MT1F:    About MalaCards
    keloids    renal cell carcinoma    pancreatic cancer    breast cancer
    hepatocellular carcinoma    pancreatitis    colon cancer    colorectal cancer
    neuronitis    hepatitis


    MT1F for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MT1F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 32 9 11291768 (3), 11510698 (3), 15188022 (1), 11756227 (1) (see all 5)
    tumors 0 3 15188022 (1), 18755257 (1), 11888668 (1)

    Genetic Association Database (GAD): MT1F

    Export disorders for MT1F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT1F gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with MT1F)
        Utopia: connect your pdf to the dynamic
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    1. Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. (PubMed id 2581970)1, 2, 3 Schmidt C.J....Hamer D.H. (1985)
    2. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structure and expression of the human metallothionein genes. (PubMed id 2444457)1, 2 Gedamu L.... Shworak N.W. (1987)
    5. Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. (PubMed id 3023827)1, 2 Varshney U.... Gedamu L. (1986)
    6. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (1984)
    7. Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. (PubMed id 9831543)1, 9 Garrett S.H....Sens D.A. (1998)
    8. Significance of metallothionein expression in breast myoepithelial cells. (PubMed id 11291768)1, 9 Jin R....Dheen T. (2001)
    9. Fine ambient particles induce oxidative stress and me tal binding genes in human alveolar macrophages. (PubMed id 19251948)1, 9 Huang Y.C....Yang I.V. (2009)
    10. Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PubMed id 10774930)1, 9 Vandeghinste N....De Ley M. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4494 HGNC: 7398 AceView: MT1_ Ensembl:ENSG00000198417 euGenes: HUgn4494
    ECgene: MT1F Kegg: 4494 H-InvDB: MT1F

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for MT1F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for MT1F gene:
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