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Aliases for MT1E Gene

Aliases for MT1E Gene

  • Metallothionein 1E 2 3
  • Metallothionein-IE 3 4
  • MT-1E 3 4
  • MT-IE 3 4
  • Metallothionein 1E (Functional) 3
  • Metallothionein D 3
  • MT1 3
  • MTD 3

External Ids for MT1E Gene

Previous HGNC Symbols for MT1E Gene

  • MT1

Previous GeneCards Identifiers for MT1E Gene

  • GC16U990040
  • GC16M056702
  • GC16P056387
  • GC16P056429
  • GC16P056435
  • GC16P055216
  • GC16P056659

Summaries for MT1E Gene

GeneCards Summary for MT1E Gene

MT1E (Metallothionein 1E) is a Protein Coding gene. Among its related pathways are Mineral absorption. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1E Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1E Gene

Genomics for MT1E Gene

Regulatory Elements for MT1E Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MT1E Gene

Chromosome:
16
Start:
56,625,475 bp from pter
End:
56,627,112 bp from pter
Size:
1,638 bases
Orientation:
Plus strand

Genomic View for MT1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT1E Gene

Proteins for MT1E Gene

  • Protein details for MT1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04732-MT1E_HUMAN
    Recommended name:
    Metallothionein-1E
    Protein Accession:
    P04732
    Secondary Accessions:
    • A2RRF7
    • Q86YX4
    • Q8TD51

    Protein attributes for MT1E Gene

    Size:
    61 amino acids
    Molecular mass:
    6014 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for MT1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MT1E Gene

Proteomics data for MT1E Gene at MOPED

Post-translational modifications for MT1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1E Gene

Domains & Families for MT1E Gene

Gene Families for MT1E Gene

Suggested Antigen Peptide Sequences for MT1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04732

UniProtKB/Swiss-Prot:

MT1E_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1E: view

Function for MT1E Gene

Molecular function for MT1E Gene

GENATLAS Biochemistry:
metallothionein 1E cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1E: view

Phenotypes for MT1E Gene

GenomeRNAi human phenotypes for MT1E:
genes like me logo Genes that share phenotypes with MT1E: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1E Gene

Localization for MT1E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1E Gene COMPARTMENTS Subcellular localization image for MT1E gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8619255
GO:0005737 cytoplasm IDA 8619255
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1E Gene

Pathways & Interactions for MT1E Gene

SuperPathways for MT1E Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1E: view

Pathways by source for MT1E Gene

1 KEGG pathway for MT1E Gene

Interacting Proteins for MT1E Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307706%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000398698%0d%0a
Selected Interacting proteins: ENSP00000307706 for MT1E Gene via STRING

Gene Ontology (GO) - Biological Process for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 8119276
genes like me logo Genes that share ontologies with MT1E: view

No data available for SIGNOR curated interactions for MT1E Gene

Drugs & Compounds for MT1E Gene

(3) Drugs for MT1E Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Copper Pharma 143
estrogen Pharma 0

(2) Additional Compounds for MT1E Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
glyceraldehyde 3-phosphate
genes like me logo Genes that share compounds with MT1E: view

Transcripts for MT1E Gene

mRNA/cDNA for MT1E Gene

Unigene Clusters for MT1E Gene

Metallothionein 1E:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1E

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1E Gene

No ASD Table

Relevant External Links for MT1E Gene

GeneLoc Exon Structure for
MT1E
ECgene alternative splicing isoforms for
MT1E

Expression for MT1E Gene

mRNA expression in normal human tissues for MT1E Gene

mRNA differential expression in normal tissues according to GTEx for MT1E Gene

This gene is overexpressed in Liver (x7.7).

Protein differential expression in normal tissues from HIPED for MT1E Gene

This gene is overexpressed in Liver, secretome (32.3) and Fetal Liver (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MT1E Gene



SOURCE GeneReport for Unigene cluster for MT1E Gene Hs.744893

genes like me logo Genes that share expression patterns with MT1E: view

Protein tissue co-expression partners for MT1E Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MT1E Gene

Orthologs for MT1E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MT1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1E 36
  • 93 (a)
OneToOne
Species with no ortholog for MT1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1E Gene

ENSEMBL:
Gene Tree for MT1E (if available)
TreeFam:
Gene Tree for MT1E (if available)

Paralogs for MT1E Gene

Paralogs for MT1E Gene

(14) SIMAP similar genes for MT1E Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MT1E Gene

genes like me logo Genes that share paralogs with MT1E: view

Variants for MT1E Gene

Sequence variations from dbSNP and Humsavar for MT1E Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs708274 -- 56,626,994(+) TCCCA(G/T)ATGTA utr-variant-3-prime, downstream-variant-500B
rs931711 -- 56,627,265(+) CACTT(A/C)TGTAA downstream-variant-500B
rs931712 -- 56,627,271(+) TGTAA(A/G)ATGGC downstream-variant-500B
rs1610215 -- 56,625,613(+) GGTGC(C/G)CACCG upstream-variant-2KB
rs2018331 -- 56,625,108(+) AGGGG(G/T)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1E Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294

Variation tolerance for MT1E Gene

Residual Variation Intolerance Score: 83.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1E Gene

HapMap Linkage Disequilibrium report
MT1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1E Gene

Disorders for MT1E Gene

Relevant External Links for MT1E

Genetic Association Database (GAD)
MT1E
Human Genome Epidemiology (HuGE) Navigator
MT1E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1E
genes like me logo Genes that share disorders with MT1E: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1E Gene

Publications for MT1E Gene

  1. Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas. (PMID: 19420986) Tse K.Y. … Ngan H.Y. (Tumour Biol. 2009) 23 67
  2. Metallothionein in human thrombocyte precursors, CD61+ megakaryocytes. (PMID: 17468938) Rahman M.T. … De Ley M. (Cell Biol. Toxicol. 2008) 23 67
  3. Alterations in metal toxicity and metal-induced metallothionein gene expression elicited by growth medium calcium concentration. (PMID: 17999152) Singh R.K. … Garrett S.H. (Cell Biol. Toxicol. 2008) 23 67
  4. Basal and metal-induced expression of metallothionein isoform 1 and 2 genes in the RWPE-1 human prostate epithelial cell line. (PMID: 17590860) Albrecht A.L. … Garrett S.H. (J Appl Toxicol 2008) 23 67
  5. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. (PMID: 18992145) Choi K.H. … Webster M.J. (BMC Psychiatry 2008) 23 67

Products for MT1E Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1E
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1E
    • Block miRNA regulation of MT1E using miScript Target Protectors

    Sources for MT1E Gene

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