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Aliases for MT1E Gene

Aliases for MT1E Gene

  • Metallothionein 1E 2 3
  • Metallothionein-IE 3 4
  • MT-1E 3 4
  • MT-IE 3 4
  • Metallothionein 1E (Functional) 3
  • Metallothionein-1E 3
  • Metallothionein D 3
  • MT1 3
  • MTD 3

External Ids for MT1E Gene

Previous HGNC Symbols for MT1E Gene

  • MT1

Previous GeneCards Identifiers for MT1E Gene

  • GC16U990040
  • GC16M056702
  • GC16P056387
  • GC16P056429
  • GC16P056435
  • GC16P055216
  • GC16P056659

Summaries for MT1E Gene

GeneCards Summary for MT1E Gene

MT1E (Metallothionein 1E) is a Protein Coding gene. Diseases associated with MT1E include prostate cancer. Among its related pathways are Mineral absorption. GO annotations related to this gene include copper ion binding and cadmium ion binding. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1E Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1E Gene

Genomics for MT1E Gene

Regulatory Elements for MT1E Gene

Genomic Location for MT1E Gene

Start:
56,625,475 bp from pter
End:
56,627,112 bp from pter
Size:
1,638 bases
Orientation:
Plus strand

Genomic View for MT1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1E Gene

Proteins for MT1E Gene

  • Protein details for MT1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04732-MT1E_HUMAN
    Recommended name:
    Metallothionein-1E
    Protein Accession:
    P04732
    Secondary Accessions:
    • A2RRF7
    • Q86YX4
    • Q8TD51

    Protein attributes for MT1E Gene

    Size:
    61 amino acids
    Molecular mass:
    6014 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for MT1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MT1E Gene

Proteomics data for MT1E Gene at MOPED

Post-translational modifications for MT1E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1E Gene

Domains for MT1E Gene

Gene Families for MT1E Gene

HGNC:
  • MT :Metallothioneins

Suggested Antigen Peptide Sequences for MT1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04732

UniProtKB/Swiss-Prot:

MT1E_HUMAN :
  • P04732
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1E: view

Function for MT1E Gene

Molecular function for MT1E Gene

GENATLAS Biochemistry: metallothionein 1E cluster
UniProtKB/Swiss-Prot Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1E: view

miRNA for MT1E Gene

miRTarBase miRNAs that target MT1E

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MT1E Gene

Localization for MT1E Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1E Gene COMPARTMENTS Subcellular localization image for MT1E gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8619255
GO:0005737 cytoplasm IDA 8619255
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1E Gene

Pathways for MT1E Gene

SuperPathways for MT1E Gene

Superpath Contained pathways
1 Mineral absorption
genes like me logo Genes that share pathways with MT1E: view

Pathways by source for MT1E Gene

1 KEGG pathway for MT1E Gene

Interacting Proteins for MT1E Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307706%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000398698%0d%0a
Selected Interacting proteins: ENSP00000307706 for MT1E Gene via STRING

Gene Ontology (GO) - Biological Process for MT1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 11168427
genes like me logo Genes that share ontologies with MT1E: view

Compounds for MT1E Gene

(1) HMDB Compounds for MT1E Gene

Compound Synonyms Cas Number PubMed IDs
Cadmium
  • Cd
7440-43-9

(5) Novoseek inferred chemical compound relationships for MT1E Gene

Compound -log(P) Hits PubMed IDs
cadmium 64.6 3
glyceraldehyde 3-phosphate 43 2
zinc 38.7 5
estrogen 29.1 13
copper 16.9 2
genes like me logo Genes that share compounds with MT1E: view

Transcripts for MT1E Gene

mRNA/cDNA for MT1E Gene

Unigene Clusters for MT1E Gene

Metallothionein 1E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MT1E Gene

No ASD Table

Relevant External Links for MT1E Gene

GeneLoc Exon Structure for
MT1E
ECgene alternative splicing isoforms for
MT1E

Expression for MT1E Gene

mRNA expression in normal human tissues for MT1E Gene

mRNA differential expression in normal tissues according to GTEx for MT1E Gene

This gene is overexpressed in Liver (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MT1E Gene

SOURCE GeneReport for Unigene cluster for MT1E Gene Hs.744893

genes like me logo Genes that share expressions with MT1E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MT1E Gene

Orthologs for MT1E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MT1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1E 36
  • 93 (a)
OneToOne
Species with no ortholog for MT1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1E Gene

ENSEMBL:
Gene Tree for MT1E (if available)
TreeFam:
Gene Tree for MT1E (if available)

Paralogs for MT1E Gene

Paralogs for MT1E Gene

Selected SIMAP similar genes for MT1E Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MT1E Gene

genes like me logo Genes that share paralogs with MT1E: view

Variants for MT1E Gene

Sequence variations from dbSNP and Humsavar for MT1E Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs708274 -- 56,626,994(+) TCCCA(G/T)ATGTA utr-variant-3-prime, downstream-variant-500B
rs931711 -- 56,627,265(+) CACTT(A/C)TGTAA downstream-variant-500B
rs931712 -- 56,627,271(+) TGTAA(A/G)ATGGC downstream-variant-500B
rs1610215 -- 56,625,613(+) GGTGC(C/G)CACCG upstream-variant-2KB
rs2018331 -- 56,625,108(+) AGGGG(G/T)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1E Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294

Relevant External Links for MT1E Gene

HapMap Linkage Disequilibrium report
MT1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1E Gene

Disorders for MT1E Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MT1E Gene including...

Search for MT1E Gene in MalaCards »

(5) Novoseek inferred disease relationships for MT1E Gene

Disease -log(P) Hits PubMed IDs
breast cancer 33.8 13
bladder cancer 29.5 3
prostate cancer 24.4 1
tumors 17.8 4
cancer 0 4

Relevant External Links for MT1E

Genetic Association Database (GAD)
MT1E
Human Genome Epidemiology (HuGE) Navigator
MT1E
genes like me logo Genes that share disorders with MT1E: view

No data available for UniProtKB/Swiss-Prot for MT1E Gene

Publications for MT1E Gene

  1. Induction by zinc of specific metallothionein isoforms in human monocytes. (PMID: 8119276) Pauwels M. … Ley M. (Eur. J. Biochem. 1994) 3 4 23
  2. Structure and expression of two human metallothionein-I isoform genes and a related pseudogene. (PMID: 2581970) Schmidt C.J. … Hamer D.H. (J. Biol. Chem. 1985) 2 3 4
  3. Interleukin-1 beta-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum. (PMID: 7932184) Kondo Y. … Lazo J.S. (J. Pharmacol. Exp. Ther. 1994) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PMID: 10774930) Vandeghinste N. … De Ley M. (Cell. Mol. Biol. (Noisy-le-grand) 2000) 3 23

Products for MT1E Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1E
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1E
    • Block miRNA regulation of MT1E using miScript Target Protectors

    Sources for MT1E Gene

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