MT1B Gene
protein-coding GIFtS: 47
GCID: GC16P056685
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metallothionein 1B(Previous name: metallothionein 1Q )
(Previous symbols: MT1, MT1Q)
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Aliases
for MT1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Metallothionein 1B1 2 | | MTP2 | | MT1Q1 2 3 | | Metallothionein 1B (Functional)2 | | MT11 2 | | Metallothionein-1B1 | | Metallothionein 1Q1 2 | | Metallothionein-IB3 | | MT-1B2 3 | | Metallothionein-IB3 | | MT-IB2 3 | | |
Export aliases for MT1B gene to outside databasesPrevious GC identifers: GC16P047069 GC16M056736 GC16P056420 GC16P056443 GC16P056448 GC16P055231 GC16P055243 GC16P042555 |
Summaries
for MT1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids
Gene Wiki entry for MT1B
|
Genomic Views
for MT1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MT1B gene promoter:
HEN1 Sp1 AP-4 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13MT1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P056685: view genomic region
(about GC identifiers)
Start:
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56,685,811 bp from pter |
End:
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56,687,116 bp from pter |
Size:
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1,306 bases |
Orientation:
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plus strand |
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Proteins
for MT1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438 (See
protein sequence)Recommended Name: Metallothionein-1B Size: 61 amino acids; 6115 Da
Subunit: MonomerExplore the universe of human proteins at neXtProt for MT1B: NX_P07438
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P07438
MT1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005938.1
ENSEMBL proteins: ENSP00000334998 ENSP00000456056
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MT1B for ontologies About GeneDecksing
MT1B Antibody Products:
Assay Products for MT1B: |
Protein
Domains /
Families
for MT1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MT1B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P07438ProtoNet protein and cluster: P07438 UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A ofthe alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, thecorresponding region within the beta domain, can ligate three divalent ions to 9 cysteinesSimilarity: Belongs to the metallothionein superfamily. Type 1 family |
Function
for MT1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids Genatlas biochemistry entry for MT1B:metallothionein 1B cluster
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MT1B (NM_020990) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MT1B for ontologies About GeneDecksing
|
Pathways & Interactions
for MT1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mineral absorption | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for MT1B):
MT1B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1B
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MT1B for ontologies About GeneDecksing
|
Drugs & Compounds
for MT1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MT1B for compounds About GeneDecksing
 Browse Tocris compounds for MT1B
1 HMDB Compound for MT1B About this table
1 Novoseek chemical compound relationship for MT1B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cadmium |
57 |
1 |
15952643 (1) |
Search CenterWatch for drugs/clinical trials and news about MT1B
|
Transcripts
for MT1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MT1B gene: NM_005947.2 Unigene Cluster for MT1B: Metallothionein 1B Hs.656629 [show with all ESTs]Unigene Representative Sequence: BU6633372 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334346(uc002ejs.3) ENST00000562399
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MT1B (NM_020990) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1B |
Additional cDNA sequence: AF349000.2 AY168638.1 BC069421.1 BC137478.1 BC137479.1 5 DOTS entries: DT.120684974 DT.406271 DT.100008764 DT.100001400 DT.120684801 21 AceView cDNA sequences: BC069421 H72723 BX118979 BF973961 NM_176870 AA370427 AY168638 AI719425 NM_005947 BC028280 BG217075 R99207 BU663337 H72722 AF349000 BG183187 R99208 BG221550 BG192094 BG220590 BG195149
GeneLoc Exon Structure
|
Expression
for MT1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MT1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MT1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT1B
SOURCE GeneReport for Unigene cluster: Hs.656629
SABiosciences Custom PCR Arrays for MT1B
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MT1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1B |
Orthologs
for MT1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MT1B gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
MT36 |
-- |
73(a) |
1 → many |
GL343675.1(182526-186438) |
zebrafish
(Danio rerio) |
Actinopterygii |
mt26 |
metallothionein 2 |
62(a) |
1 → many |
18(17193795-17195147) |
ENSEMBL Gene Tree for MT1B (if available)
TreeFam Gene Tree for MT1B (if available) |
Paralogs
for MT1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MT1B gene
- MT1G2 MT1E2 MT1X2 MT1F2 MT2A2 MT42 MT1M2 MT32
- MT1H2 MT1A2
12 SIMAP similar genes for MT1B using alignment to 2 protein entries: MT1B_HUMAN (see all proteins):MTP MT1A MT1L MT1F MT1H MT2A
MT1X MT1M MTE MT1E MT1G MT4
MT1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MT1B
PGOHUM00000262341
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Genomic Variants
for MT1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MT1B (56685811 - 56687116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MT1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1B |
|
Disorders
/ Diseases
for MT1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MT1B for disorders About GeneDecksing
OMIM gene information: 156349
OMIM disorders: --
7  diseases for MT1B: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis acute lymphoblastic leukemia lymphoblastic leukemia
pancreatic cancer leukemia pancreatitis
Export disorders for MT1B gene to outside databases
|
Publications
for MT1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MT1B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MT1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and tissue-specific expression of the human metallothionein IB gene. (PubMed id 3785191)1, 2, 3 Heguy A....Karin M. (1986)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (1984)
- Genome-wide association study of a quantitative disord ered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (2012)
- Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. (PubMed id 17244347)1 Lederer C.W....Cavallaro S. (2007)
- HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)1 Izmailova E....Aldovini A. (2003)
- Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776)1 Sun N.N....Witten M.L. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PubMed id 11168427)1 Rahman M.T. and De Ley M. (2001)
- Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1 West A.K....Richards R.I. (1990)
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External Searches for MT1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MT1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MT1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MT1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MT1B gene:
Search GeneIP for patents involving MT1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MT1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MT1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1B | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for MT1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MT1B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MT1B | | OriGene Custom Protein Services for MT1B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1B |
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| | | | Search Tocris compounds for MT1B |
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 | | | MT1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MT1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1B |
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