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MT1B Gene

protein-coding   GIFtS: 46
GCID: GC16P056685

Metallothionein 1B

(Previous name: metallothionein 1Q)
(Previous symbols: MT1, MT1Q)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein 1B1 2     MTP2
MT1Q1 2 3     Metallothionein 1B (Functional)2
MT11 2     metallothionein-1B2
Metallothionein 1Q1 2     metallothionein-IB2
MT-1B2 3     Metallothionein-IB3
MT-IB2 3     

External Ids:    HGNC: 73941   Entrez Gene: 44902   Ensembl: ENSG000001696887   OMIM: 1563495   UniProtKB: P074383   

Export aliases for MT1B gene to outside databases

Previous GC identifers: GC16P047069 GC16M056736 GC16P056420 GC16P056443 GC16P056448 GC16P055231 GC16P055243 GC16P042555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT1B Gene:
MT1B (metallothionein 1B) is a protein-coding gene. Diseases associated with MT1B include lateral sclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include cadmium ion binding and copper ion binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT1B gene promoter:
         HEN1   Sp1   AP-4   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT1B promoter sequence
   Search Chromatin IP Primers for MT1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056685:  view genomic region     (about GC identifiers)

Start:
56,685,811 bp from pter      End:
56,687,116 bp from pter
Size:
1,306 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438 (See protein sequence)
Recommended Name: Metallothionein-1B  
Size: 61 amino acids; 6115 Da
Subunit: Monomer
Secondary accessions: Q86YX0

Explore the universe of human proteins at neXtProt for MT1B: NX_P07438

Explore proteomics data for MT1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MT1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005938.1  
    ENSEMBL proteins: 
     ENSP00000334998   ENSP00000456056  

    MT1B Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for MT1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P07438

    ProtoNet protein and cluster: P07438

    UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    MT1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT1B_HUMAN, P07438
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1B:
    metallothionein 1B cluster

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding ----
    GO:0008270zinc ion binding ISS--
    GO:0046870cadmium ion binding ----
    GO:0046872metal ion binding ----
         
    MT1B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT1B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0048471perinuclear region of cytoplasm ISS--

    MT1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT1B About    
    See pathways by source

    SuperPathContained pathways About
    1Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MT1B):
        Mineral absorption


    MT1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT1B
    Interactions:

        Search GeneGlobe Interaction Network for MT1B

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045926negative regulation of growth ISS--
    GO:0071294cellular response to zinc ion IEP11168427

    MT1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT1B

    1 HMDB Compound for MT1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--

    1 Novoseek inferred chemical compound relationship for MT1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 57 1 15952643 (1)



    MT1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MT1B gene: 
    NM_005947.2  

    Unigene Cluster for MT1B:

    Metallothionein 1B
    Hs.656629  [show with all ESTs]
    Unigene Representative Sequence: BU663337
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334346(uc002ejs.3) ENST00000562399
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MT1B
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    GenScript: all cDNA clones in your preferred vector: MT1B (NM_020990)
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    Primer
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    Additional mRNA sequence: 

    AF349000.2 AY168638.1 BC069421.1 BC137478.1 BC137479.1 

    5 DOTS entries:

    DT.120684974  DT.406271  DT.100008764  DT.100001400  DT.120684801 

    21 AceView cDNA sequences:

    BX118979 BC069421 H72723 NM_176870 BF973961 BC028280 AA370427 NM_005947 
    AY168638 AI719425 BG217075 AF349000 R99207 BU663337 H72722 BG221550 
    BG183187 R99208 BG192094 BG220590 BG195149 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT1B Expression
    About this image

    MT1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656629
        Custom PCR Arrays for MT1B
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for MT1B gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia MT1B1 metallothionein 1B 98.36(n)
    98.36(a)
      467981  XM_001139997.1  XP_001139997.1 


    ENSEMBL Gene Tree for MT1B (if available)
    TreeFam Gene Tree for MT1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT1B gene
    MT1G2  MT1E2  MT1F2  MT1X2  MT2A2  MT1HL12  MT1M2  MT1H2  
    MT1A2  
    12 SIMAP similar genes for MT1B using alignment to 2 protein entries:     MT1B_HUMAN (see all proteins):
    MT1A    MT1L    MT1F    MT1H    MT2A    MT1HL1
    MT1X    MT1M    MTE    MT1E    MT1G    MT4

    MT1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MT1B
    PGOHUM00000262341


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MT1B (see all 130)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169760261,2
    C,F--56683849(+) GTATAG/AGTTTG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs71917791,2
    C,A--56683891(+) ccaagC/Gtgtgt 1 -- us2k16Minor allele frequency- G:0.36NA CSA WA EA 363
    rs18752321,2
    C,F,A,H--56683911(+) tatcaG/Tctagg 1 -- us2k115Minor allele frequency- T:0.32NS EA NA CSA 1982
    rs1483086311,2
    C--56683916(+) GCTAG-/GTGTGTG 1 -- us2k10--------
    rs71974891,2
    C,F,A,H--56683993(+) acctcT/Ccatta 1 -- us2k126Minor allele frequency- C:0.23NS EA NA WA 3186
    rs788188541,2
    F--56684082(+) TGTACA/GTGACC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1129569881,2
    F--56684111(+) CTACTG/ATTTTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1855683301,2
    --56684151(+) AATGCC/TTGTGT 1 -- us2k10--------
    rs1174786821,2
    F--56684157(+) TGTGTC/TCCTCC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs116471901,2
    C,F,A,H--56684241(+) CATGCG/AGGCAA 1 -- us2k112Minor allele frequency- A:0.42NA WA CSA EA 377

    HapMap Linkage Disequilibrium report for MT1B (56685811 - 56687116 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MT1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906720CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MT1B
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156349    OMIM disorders: --

    7 diseases for MT1B:    
    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    lymphoblastic leukemia    pancreatic cancer
    hiv-1    pancreatitis    leukemia


    MT1B for disorders           About GeneDecksing


    Export disorders for MT1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT1B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with MT1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and tissue-specific expression of the human metallothionein IB gene. (PubMed id 3785191)1, 2, 3 Heguy A.... Karin M. (Mol. Cell. Biol. 1986)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (Proc. Natl. Acad. Sci. U.S.A. 1984)
    4. Genome-wide association study of a quantitative disordered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (Addict Biol 2013)
    5. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. (PubMed id 17244347)1 Lederer C.W....Cavallaro S. (BMC Genomics 2007)
    6. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)1 Izmailova E....Aldovini A. (Nat. Med. 2003)
    7. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776)1 Sun N.N....Witten M.L. (Toxicol Ind Health 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PubMed id 11168427)1 Rahman M.T. and De Ley M. (Eur. J. Biochem. 2001)
    10. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1 West A.K....Richards R.I. (Genomics 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4490 HGNC: 7394 AceView: MT1BandMT1K Ensembl:ENSG00000169688 euGenes: HUgn4490
    ECgene: MT1B Kegg: 4490 H-InvDB: MT1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT1B gene:
    Search GeneIP for patents involving MT1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MT1B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MT1B  
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     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MT1B   OriGene Custom Protein Services for MT1B  

     
     
     Block miRNA regulation of human, mouse, rat MT1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MT1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1B Predesigned siRNA for gene silencing in human, mouse, rat MT1B
     QuantiFast Probe-based Assays in human, mouse, rat MT1B QuantiTect SYBR Green Assays in human, mouse, rat MT1B
     Custom PCR Arrays for MT1B Search Chromatin IP Primers for MT1B
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     Search Tocris compounds for MT1B
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for MT1B
     Gene Synthesis
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     Search ThermoFisher Antibodies for MT1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT1B
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     Search LSBio for Antibodies for MT1B
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