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Aliases for MT1B Gene

Aliases for MT1B Gene

  • Metallothionein 1B 2 3 5
  • Metallothionein 1Q 2 3
  • Metallothionein-IB 3 4
  • MT-1B 3 4
  • MT-IB 3 4
  • MT1Q 3 4
  • Metallothionein 1B (Functional) 3
  • Metallothionein-1B 3
  • MT1 3
  • MTP 3

External Ids for MT1B Gene

Previous HGNC Symbols for MT1B Gene

  • MT1
  • MT1Q

Previous GeneCards Identifiers for MT1B Gene

  • GC16P047069
  • GC16M056736
  • GC16P056420
  • GC16P056443
  • GC16P056448
  • GC16P055231
  • GC16P055243
  • GC16P056685
  • GC16P042555

Summaries for MT1B Gene

Entrez Gene Summary for MT1B Gene

  • The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

GeneCards Summary for MT1B Gene

MT1B (Metallothionein 1B) is a Protein Coding gene. Among its related pathways are Copper homeostasis and Response to metal ions.

UniProtKB/Swiss-Prot for MT1B Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1B Gene

Genomics for MT1B Gene

Regulatory Elements for MT1B Gene

Enhancers for MT1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G056604 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -41.7 -41744 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 BBS2 MT1A MT1F MT1G MT1H MT3 MT1DP MT1CP MT1B POLR2C
GH16G056603 1.4 Ensembl ENCODE dbSUPER 10.9 -48.0 -48036 0.5 ELF3 PKNOX1 ARID4B ZSCAN9 RAD21 RARA ZNF121 ZNF143 MIXL1 ZNF263 MT1G MT1H MT1B MT1X MT1A MT2A MT3
GH16G056624 1 ENCODE 11.5 -25.6 -25645 3.0 ARID4B FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNF143 FOS MXD4 MIER2 MT1E MT3 MT1G MT1H MT1B MT1F MT1X MT1A BBS2 NUP93
GH16G056576 1 ENCODE 10.9 -74.7 -74700 0.9 PKNOX1 ARID4B ZNF48 YY1 ZNF207 ZNF143 ZNF263 REST MIER2 TBX21 MT1DP MT1CP MT1X MT1F MT1B MT4 GC16P056575 MT3
GH16G056616 0.9 ENCODE dbSUPER 11.3 -34.1 -34069 1.9 RNF2 SUZ12 TAF1 CBX2 MAX RBBP5 RAD21 YY1 HDAC2 POLR2A MT1A MT1F MT1G MT1H MT1CP MT1DP MT1B MT3 MT1E MT1X
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MT1B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MT1B gene promoter:

Genomic Location for MT1B Gene

Chromosome:
16
Start:
56,651,899 bp from pter
End:
56,653,204 bp from pter
Size:
1,306 bases
Orientation:
Plus strand

Genomic View for MT1B Gene

Genes around MT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1B Gene

Proteins for MT1B Gene

  • Protein details for MT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07438-MT1B_HUMAN
    Recommended name:
    Metallothionein-1B
    Protein Accession:
    P07438
    Secondary Accessions:
    • Q86YX0

    Protein attributes for MT1B Gene

    Size:
    61 amino acids
    Molecular mass:
    6115 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1B Gene

Post-translational modifications for MT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1B Gene

Domains & Families for MT1B Gene

Gene Families for MT1B Gene

Suggested Antigen Peptide Sequences for MT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07438

UniProtKB/Swiss-Prot:

MT1B_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1B: view

Function for MT1B Gene

Molecular function for MT1B Gene

GENATLAS Biochemistry:
metallothionein 1B cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT1B: view
genes like me logo Genes that share phenotypes with MT1B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT1B Gene

Localization for MT1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT1B gene
Compartment Confidence
nucleus 4
extracellular 3

Gene Ontology (GO) - Cellular Components for MT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1B Gene

Pathways & Interactions for MT1B Gene

genes like me logo Genes that share pathways with MT1B: view

Pathways by source for MT1B Gene

2 BioSystems pathways for MT1B Gene
1 KEGG pathway for MT1B Gene

Interacting Proteins for MT1B Gene

Selected Interacting proteins: P07438-MT1B_HUMAN for MT1B Gene via IID

Gene Ontology (GO) - Biological Process for MT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071294 cellular response to zinc ion IEP 11168427
genes like me logo Genes that share ontologies with MT1B: view

No data available for SIGNOR curated interactions for MT1B Gene

Drugs & Compounds for MT1B Gene

(1) Additional Compounds for MT1B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1B: view

Transcripts for MT1B Gene

mRNA/cDNA for MT1B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1B Gene

Metallothionein 1B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1B Gene

No ASD Table

Relevant External Links for MT1B Gene

GeneLoc Exon Structure for
MT1B
ECgene alternative splicing isoforms for
MT1B

Expression for MT1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1B Gene

mRNA differential expression in normal tissues according to GTEx for MT1B Gene

This gene is overexpressed in Liver (x49.6).

Protein differential expression in normal tissues from HIPED for MT1B Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1B Gene



Protein tissue co-expression partners for MT1B Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1B Gene:

MT1B

SOURCE GeneReport for Unigene cluster for MT1B Gene:

Hs.656629

Evidence on tissue expression from TISSUES for MT1B Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with MT1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1B Gene

Orthologs for MT1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1B 34 35
  • 98.36 (n)
Species where no ortholog for MT1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1B Gene

ENSEMBL:
Gene Tree for MT1B (if available)
TreeFam:
Gene Tree for MT1B (if available)

Paralogs for MT1B Gene

(12) SIMAP similar genes for MT1B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MT1B Gene

genes like me logo Genes that share paralogs with MT1B: view

No data available for Paralogs for MT1B Gene

Variants for MT1B Gene

Sequence variations from dbSNP and Humsavar for MT1B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001041686 -- 56,653,309(+) CCCTA(C/T)AGTCT downstream-variant-500B
rs1001468004 -- 56,653,506(+) CTTCA(G/T)TCCCT downstream-variant-500B
rs1003195071 -- 56,652,288(+) GGGAC(A/G)TAGCC intron-variant
rs1004868922 -- 56,653,163(+) TTTTT(C/T)CTATT utr-variant-3-prime
rs1005658154 -- 56,650,316(+) GAAGT(A/G)ACTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1B Gene

Variant ID Type Subtype PubMed ID
dgv2988n100 CNV gain 25217958
dgv2989n100 CNV gain 25217958
dgv524e214 CNV gain 21293372
nsv1058153 CNV gain 25217958

Variation tolerance for MT1B Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1B Gene

Disorders for MT1B Gene

Relevant External Links for MT1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1B

No disorders were found for MT1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1B Gene

Publications for MT1B Gene

  1. Structure and tissue-specific expression of the human metallothionein IB gene. (PMID: 3785191) Heguy A. … Karin M. (Mol. Cell. Biol. 1986) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human metallothionein genes are clustered on chromosome 16. (PMID: 6089206) Karin M. … Shows T.B. (Proc. Natl. Acad. Sci. U.S.A. 1984) 2 3 64
  4. Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients. (PMID: 23064051) Werynska B. … Dziegiel P. (Exp. Mol. Pathol. 2013) 3 64
  5. Genome-wide association study of a quantitative disordered gambling trait. (PMID: 22780124) Lind P.A. … Slutske W.S. (Addict Biol 2013) 3 64

Products for MT1B Gene

Sources for MT1B Gene

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