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Aliases for MT1A Gene

Aliases for MT1A Gene

  • Metallothionein 1A 2 3 5
  • Metallothionein 1S 2 3
  • Metallothionein-IA 3 4
  • MT-1A 3 4
  • MT-IA 3 4
  • MT1S 3 4
  • Metallothionein 1A (Functional) 3
  • Metallothionein-1A 3
  • MTC 3
  • MT1 3

External Ids for MT1A Gene

Previous HGNC Symbols for MT1A Gene

  • MT1
  • MT1S

Previous GeneCards Identifiers for MT1A Gene

  • GC16P047056
  • GC16M056723
  • GC16P056405
  • GC16P056442
  • GC16P056447
  • GC16P055230
  • GC16P056672
  • GC16P042542

Summaries for MT1A Gene

GeneCards Summary for MT1A Gene

MT1A (Metallothionein 1A) is a Protein Coding gene. Among its related pathways are Copper homeostasis and Response to metal ions. An important paralog of this gene is MT1E.

UniProtKB/Swiss-Prot for MT1A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1A Gene

Genomics for MT1A Gene

Regulatory Elements for MT1A Gene

Enhancers for MT1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G056604 2 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -28.5 -28511 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 BBS2 MT1A MT1F MT1H MT1G MT3 MT1DP MT1CP MT1B POLR2C
GH16G056546 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -90.9 -90946 2.0 ATF1 TAF1 RBBP5 CHD7 GTF3C2 ZNF366 POLR2A NFE2 ZBTB20 NFE2L2 BBS2 MT3 RSPRY1 MT4 MT1A MT1G MT1H GNAO1
GH16G056603 1.4 Ensembl ENCODE dbSUPER 10.5 -34.8 -34803 0.5 ELF3 PKNOX1 ARID4B ZSCAN9 RAD21 RARA ZNF121 ZNF143 MIXL1 ZNF263 MT1G MT1H MT1B MT1X MT1A MT2A MT3
GH16G056518 1.3 ENCODE dbSUPER 10.5 -119.1 -119115 2.9 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP5 MXD4 REST BBS2 OGFOD1 MT3 MT1G MT1H MT1A NUDT21 MT4 ENSG00000274031
GH16G056616 0.9 ENCODE dbSUPER 12.3 -20.8 -20836 1.9 RNF2 SUZ12 TAF1 CBX2 MAX RBBP5 RAD21 YY1 HDAC2 POLR2A MT1A MT1F MT1G MT1H MT1CP MT1DP MT1B MT3 MT1E MT1X
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MT1A on UCSC Golden Path with GeneCards custom track

Promoters for MT1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086302 -166 201 DRAP1 SAP130 SUZ12 TAF1 MAX ZNF48 RARA ZNF664 POLR2A HNF4G

Transcription factor binding sites by QIAGEN in the MT1A gene promoter:

Genomic Location for MT1A Gene

Chromosome:
16
Start:
56,638,666 bp from pter
End:
56,640,087 bp from pter
Size:
1,422 bases
Orientation:
Plus strand

Genomic View for MT1A Gene

Genes around MT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1A Gene

Proteins for MT1A Gene

  • Protein details for MT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04731-MT1A_HUMAN
    Recommended name:
    Metallothionein-1A
    Protein Accession:
    P04731
    Secondary Accessions:
    • Q86YX5

    Protein attributes for MT1A Gene

    Size:
    61 amino acids
    Molecular mass:
    6120 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MT1A Gene

Post-translational modifications for MT1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1A Gene

Domains & Families for MT1A Gene

Gene Families for MT1A Gene

Suggested Antigen Peptide Sequences for MT1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04731

UniProtKB/Swiss-Prot:

MT1A_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1A: view

Function for MT1A Gene

Molecular function for MT1A Gene

GENATLAS Biochemistry:
metallothionein 1A cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16442532
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT1A: view

Phenotypes for MT1A Gene

GenomeRNAi human phenotypes for MT1A:
genes like me logo Genes that share phenotypes with MT1A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MT1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MT1A Gene

Localization for MT1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT1A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1A Gene

Pathways & Interactions for MT1A Gene

genes like me logo Genes that share pathways with MT1A: view

Pathways by source for MT1A Gene

2 BioSystems pathways for MT1A Gene
1 PharmGKB pathway for MT1A Gene
1 KEGG pathway for MT1A Gene

Gene Ontology (GO) - Biological Process for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010038 response to metal ion TAS --
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 11168427
genes like me logo Genes that share ontologies with MT1A: view

No data available for SIGNOR curated interactions for MT1A Gene

Drugs & Compounds for MT1A Gene

(8) Drugs for MT1A Gene - From: DrugBank, ApexBio, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 2050
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1460
Agomelatine Approved, Investigational Pharma Antagonist MT1/MT2 / 5-HT2C agonist 0
Eloxatin Approved August 2002 Pharma 0

(4) Additional Compounds for MT1A Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9

(1) ApexBio Compounds for MT1A Gene

Compound Action Cas Number
Agomelatine MT1/MT2 / 5-HT2C agonist 138112-76-2
genes like me logo Genes that share compounds with MT1A: view

Drug Products

Transcripts for MT1A Gene

mRNA/cDNA for MT1A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1A Gene

Metallothionein 1A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MT1A

Alternative Splicing Database (ASD) splice patterns (SP) for MT1A Gene

No ASD Table

Relevant External Links for MT1A Gene

GeneLoc Exon Structure for
MT1A
ECgene alternative splicing isoforms for
MT1A

Expression for MT1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1A Gene

mRNA differential expression in normal tissues according to GTEx for MT1A Gene

This gene is overexpressed in Liver (x10.8) and Adipose - Visceral (Omentum) (x6.7).

Protein differential expression in normal tissues from HIPED for MT1A Gene

This gene is overexpressed in Liver (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MT1A Gene



Protein tissue co-expression partners for MT1A Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1A Gene:

MT1A

SOURCE GeneReport for Unigene cluster for MT1A Gene:

Hs.655199

Evidence on tissue expression from TISSUES for MT1A Gene

  • Kidney(2.9)
  • Intestine(2.8)
  • Muscle(2.6)
  • Stomach(2.5)
  • Pancreas(2.1)
  • Liver(4.7)
genes like me logo Genes that share expression patterns with MT1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1A Gene

Orthologs for MT1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1A 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mt1 35
  • 82 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia MT1E 35
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
ManyToMany
Species where no ortholog for MT1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1A Gene

ENSEMBL:
Gene Tree for MT1A (if available)
TreeFam:
Gene Tree for MT1A (if available)

Paralogs for MT1A Gene

Paralogs for MT1A Gene

(12) SIMAP similar genes for MT1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1A: view

Variants for MT1A Gene

Sequence variations from dbSNP and Humsavar for MT1A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000414492 -- 56,638,570(+) GCTGG(G/T)CGGAC upstream-variant-2KB
rs1000468265 -- 56,638,822(+) GGATA(C/G)ATGTC intron-variant
rs1004262434 -- 56,638,371(+) CGGGG(A/T)AACTG upstream-variant-2KB
rs1005877412 -- 56,639,239(+) AAATT(A/C)ACTGC intron-variant
rs1009176788 -- 56,637,965(+) GTGGG(G/T)AGCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MT1A Gene

Variant ID Type Subtype PubMed ID
dgv2988n100 CNV gain 25217958
dgv2989n100 CNV gain 25217958
dgv524e214 CNV gain 21293372
esv2669588 CNV deletion 23128226
esv3638704 CNV loss 21293372
nsv1058153 CNV gain 25217958
nsv572696 CNV loss 21841781

Variation tolerance for MT1A Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.59; 93.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1A Gene

Human Gene Mutation Database (HGMD)
MT1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1A Gene

Disorders for MT1A Gene

Relevant External Links for MT1A

Genetic Association Database (GAD)
MT1A
Human Genome Epidemiology (HuGE) Navigator
MT1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1A

No disorders were found for MT1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1A Gene

Publications for MT1A Gene

  1. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. (PMID: 6327055) Richards R.I. … Karin M. (Cell 1984) 2 3 4 64
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  3. Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort. (PMID: 19962295) Giacconi R. … Mocchegiani E. (J. Nutr. Biochem. 2010) 3 46 64
  4. Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure. (PMID: 19359654) Chang X. … Lei L. (Exp. Biol. Med. (Maywood) 2009) 3 22 64
  5. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PMID: 19515364) Gundacker C. … Gencik M. (Environ. Res. 2009) 3 46 64

Products for MT1A Gene

Sources for MT1A Gene

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