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Aliases for MT1A Gene

Aliases for MT1A Gene

  • Metallothionein 1A 2 3
  • Metallothionein 1S 2 3
  • Metallothionein-IA 3 4
  • MT-1A 3 4
  • MT-IA 3 4
  • MT1S 3 4
  • Metallothionein 1A (Functional) 3
  • Metallothionein-1A 3
  • MTC 3
  • MT1 3

External Ids for MT1A Gene

Previous HGNC Symbols for MT1A Gene

  • MT1
  • MT1S

Previous GeneCards Identifiers for MT1A Gene

  • GC16P047056
  • GC16M056723
  • GC16P056405
  • GC16P056442
  • GC16P056447
  • GC16P055230
  • GC16P056672
  • GC16P042542

Summaries for MT1A Gene

GeneCards Summary for MT1A Gene

MT1A (Metallothionein 1A) is a Protein Coding gene. Diseases associated with MT1A include cerebral lymphoma and keloids. Among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include copper ion binding and cadmium ion binding. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1A Gene

Genomics for MT1A Gene

Regulatory Elements for MT1A Gene

Transcription factor binding sites by QIAGEN in the MT1A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MT1A Gene

Start:
56,638,666 bp from pter
End:
56,750,276 bp from pter
Size:
111,611 bases
Orientation:
Plus strand

Genomic View for MT1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1A Gene

Proteins for MT1A Gene

  • Protein details for MT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04731-MT1A_HUMAN
    Recommended name:
    Metallothionein-1A
    Protein Accession:
    P04731
    Secondary Accessions:
    • Q86YX5

    Protein attributes for MT1A Gene

    Size:
    61 amino acids
    Molecular mass:
    6120 Da
    Quaternary structure:
    • Monomer

neXtProt entry for MT1A Gene

Proteomics data for MT1A Gene at MOPED

Post-translational modifications for MT1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1A Gene

Domains for MT1A Gene

Gene Families for MT1A Gene

HGNC:
  • MT :Metallothioneins

Suggested Antigen Peptide Sequences for MT1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04731

UniProtKB/Swiss-Prot:

MT1A_HUMAN :
  • P04731
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1A: view

Function for MT1A Gene

Molecular function for MT1A Gene

GENATLAS Biochemistry: metallothionein 1A cluster
UniProtKB/Swiss-Prot Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16442532
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1A: view
genes like me logo Genes that share phenotypes with MT1A: view

Animal Models for MT1A Gene

MGI Knock Outs for MT1A:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MT1A Gene

Localization for MT1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1A Gene COMPARTMENTS Subcellular localization image for MT1A gene
Compartment Confidence
nucleus 4
extracellular 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1A Gene

Pathways for MT1A Gene

genes like me logo Genes that share pathways with MT1A: view

Pathways by source for MT1A Gene

1 PharmGKB pathway for MT1A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nephrotoxicity in human,mouse,rat

Gene Ontology (GO) - Biological Process for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 11168427
genes like me logo Genes that share ontologies with MT1A: view

Compounds for MT1A Gene

(1) HMDB Compounds for MT1A Gene

Compound Synonyms Cas Number PubMed IDs
Cadmium
  • Cd
7440-43-9

(7) Novoseek inferred chemical compound relationships for MT1A Gene

Compound -log(P) Hits PubMed IDs
cadmium 74.1 13
2[125i]iodomelatonin 65.4 1
cdcl2 55.1 1
zinc 50.1 8
glyceraldehyde 3-phosphate 42 1
genes like me logo Genes that share compounds with MT1A: view

Transcripts for MT1A Gene

mRNA/cDNA for MT1A Gene

(139) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1A Gene

Metallothionein 1A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1A Gene

No ASD Table

Relevant External Links for MT1A Gene

GeneLoc Exon Structure for
MT1A
ECgene alternative splicing isoforms for
MT1A

Expression for MT1A Gene

mRNA expression in normal human tissues for MT1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MT1A Gene

This gene is overexpressed in Liver (10.8) and Adipose - Visceral (Omentum) (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MT1A Gene

SOURCE GeneReport for Unigene cluster for MT1A Gene Hs.655199

genes like me logo Genes that share expressions with MT1A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MT1A Gene

Orthologs for MT1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1A 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT1E 36
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt1 16
Mt1 36
  • 82 (a)
ManyToMany
Species with no ortholog for MT1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1A Gene

ENSEMBL:
Gene Tree for MT1A (if available)
TreeFam:
Gene Tree for MT1A (if available)

Paralogs for MT1A Gene

Paralogs for MT1A Gene

Selected SIMAP similar genes for MT1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1A: view

Variants for MT1A Gene

Sequence variations from dbSNP and Humsavar for MT1A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs904776 -- 56,640,239(-) CAGGT(A/G)CCTGA downstream-variant-500B
rs904777 -- 56,640,199(-) AATAG(C/G)ACAAG downstream-variant-500B
rs1827213 -- 56,637,929(+) GAACT(A/G)CCAGA upstream-variant-2KB
rs1846692 -- 56,637,784(+) GGGCT(C/T)AAGTG upstream-variant-2KB
rs4784702 -- 56,640,570(+) CTTGG(C/T)CTGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MT1A Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
esv2669588 CNV Deletion 23128226

Relevant External Links for MT1A Gene

HapMap Linkage Disequilibrium report
MT1A
Human Gene Mutation Database (HGMD)
MT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1A Gene

Disorders for MT1A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for MT1A Gene including...

Search for MT1A Gene in MalaCards »

(5) Novoseek inferred disease relationships for MT1A Gene

Disease -log(P) Hits PubMed IDs
pancreatic cancer 15.8 1
shock 14 1
breast cancer 0 1
prostate cancer 0 2
melanoma 0 1

Relevant External Links for MT1A

Genetic Association Database (GAD)
MT1A
Human Genome Epidemiology (HuGE) Navigator
MT1A
genes like me logo Genes that share disorders with MT1A: view

No data available for UniProtKB/Swiss-Prot for MT1A Gene

Publications for MT1A Gene

  1. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. (PMID: 6327055) Richards R.I. … Karin M. (Cell 1984) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  4. Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PMID: 11168427) Rahman M.T. … De Ley M. (Eur. J. Biochem. 2001) 3 23
  5. Effect of metallothionein on cell viability and its interactions with cadmium and zinc in HEK293 cells. (PMID: 16087360) Li J. … Ru B. (Cell Biol. Int. 2005) 3 23

Products for MT1A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nephrotoxicity in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1A
    • Block miRNA regulation of MT1A using miScript Target Protectors

    Sources for MT1A Gene

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