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MT1A Gene

protein-coding   GIFtS: 54
GCID: GC16P056672

Metallothionein 1A

(Previous name: metallothionein 1S)
(Previous symbols: MT1, MT1S)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Metallothionein 1A1 2     MTC2
MT1S1 2 3     Metallothionein 1A (Functional)2
MT11 2     metallothionein-1A2
Metallothionein 1S1 2     metallothionein-IA2
MT-1A2 3     Metallothionein-IA3
MT-IA2 3     

External Ids:    HGNC: 73931   Entrez Gene: 44892   Ensembl: ENSG000002053627   OMIM: 1563505   UniProtKB: P047313   

Export aliases for MT1A gene to outside databases

Previous GC identifers: GC16P047056 GC16M056723 GC16P056405 GC16P056442 GC16P056447 GC16P055230 GC16P042542


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT1A Gene:
MT1A (metallothionein 1A) is a protein-coding gene. Diseases associated with MT1A include cerebral lymphoma, and keloids. GO annotations related to this gene include cadmium ion binding and copper ion binding. An important paralog of this gene is MT1G.

UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1A (Metallothionein 1A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MT1A gene promoter:
         TBP   p53   Sp1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMT1A promoter sequence
   Search Chromatin IP Primers for MT1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056672:  view genomic region     (about GC identifiers)

Start:
56,672,578 bp from pter      End:
56,673,999 bp from pter
Size:
1,422 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731 (See protein sequence)
Recommended Name: Metallothionein-1A  
Size: 61 amino acids; 6120 Da
Subunit: Monomer
Secondary accessions: Q86YX5

Explore the universe of human proteins at neXtProt for MT1A: NX_P04731

Explore proteomics data for MT1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MT1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005937.2  
    ENSEMBL proteins: 
     ENSP00000290705  

    MT1A Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    Abcam antibodies for MT1A
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    ThermoFisher Antibodies for MT1A
    Search LSBio for Antibodies for MT1A

    MT1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MT1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MT: Metallothioneins

    5 InterPro protein domains:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P04731

    ProtoNet protein and cluster: P04731

    UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A
    of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    MT1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MT1A_HUMAN, P04731
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins
    are transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1A:
    metallothionein 1A cluster

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding ----
    GO:0005515protein binding IPI16442532
    GO:0008270zinc ion binding ISS--
    GO:0046870cadmium ion binding ----
    GO:0046872metal ion binding ----
         
    MT1A for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mt1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  reproductive system 

    MT1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MT1A: Mt1tm1Bri Mt1tm1Rch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT1A

    miRNA
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    OriGene RNAi products in human, mouse, rat for MT1A
    Predesigned siRNA for gene silencing in human, mouse, rat MT1A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MT1A (NM_005946)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1A

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular3
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0048471perinuclear region of cytoplasm ISS--

    MT1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT1A About    
    See pathways by source

    SuperPathContained pathways About
    1Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics


    1 PharmGKB Pathway for MT1A
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including MT1A: 
              Nephrotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MT1A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MT1A (P047311, 2, 3 ENSP000002907054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR50Q135851, 2, 3, ENSP000002183164EBI-8045030,EBI-8550965 MINT-2836169 MINT-2836224 MINT-2836149 I2D: score=1 STRING: ENSP00000218316
    TP53P046371, 2, 3, ENSP000002693054EBI-8045030,EBI-366083 MINT-1781494 MINT-1781525 MINT-1781444 I2D: score=1 STRING: ENSP00000269305
    ARRB1P494072, 3, ENSP000003771414MINT-2836265 I2D: score=1 STRING: ENSP00000377141
    GNAI1P630962, 3, ENSP000003430274MINT-2836337 I2D: score=1 STRING: ENSP00000343027
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045926negative regulation of growth ISS--
    GO:0071276cellular response to cadmium ion IEP16827180
    GO:0071294cellular response to zinc ion IEP11168427

    MT1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT1A

    1 HMDB Compound for MT1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--

    7 Novoseek inferred chemical compound relationships for MT1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 74.1 22 16600086 (4), 19359654 (3), 16087360 (2), 8171441 (1) (see all 7)
    2[125i]iodomelatonin 65.4 1 11123519 (1)
    cdcl2 55.1 1 1716322 (1)
    zinc 50.1 11 18316168 (2), 16087360 (2), 18321746 (1), 17468938 (1) (see all 6)
    glyceraldehyde 3-phosphate 42 1 15952643 (1)
    copper 31.5 1 9831543 (1)
    oxygen 0 1 12553033 (1)



    MT1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MT1A gene: 
    NM_005946.2  

    Unigene Cluster for MT1A:

    Metallothionein 1A
    Hs.655199  [show with all ESTs]
    Unigene Representative Sequence: BM684446
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000290705(uc002eji.3 uc002ejq.3)

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MT1A
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MT1A
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MT1A
      QuantiTect SYBR Green Assays in human, mouse, rat MT1A
      QuantiFast Probe-based Assays in human, mouse, rat MT1A

    Additional mRNA sequence: 

    AY028617.1 BC029475.1 

    4 DOTS entries:

    DT.85100940  DT.97825490  DT.97862512  DT.95376032 

    Selected AceView cDNA sequences (see all 139):

    F30476 F25557 T27991 S68956 F27787 AI341945 CD672936 CD675632 
    BI821822 T29525 AJ712480 CB529368 F26333 BX113499 F30567 X76717 
    AW166373 CB117071 BM726910 AI343762 CD678013 AA323862 BM923250 AW192642 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTGTGCCA
    MT1A Expression
    About this image


    MT1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Colon (Gastrointestinal Tract)
    MT1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655199
        Pathway & Disease-focused RT2 Profiler PCR Array including MT1A: 
              Nephrotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MT1A gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mt15 metallothionein 1   --   8 (46.34 cM) 94179089 


    ENSEMBL Gene Tree for MT1A (if available)
    TreeFam Gene Tree for MT1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT1A gene
    MT1G2  MT1E2  MT1F2  MT1X2  MT1B2  MT2A2  MT1HL12  MT1M2  
    MT1H2  
    12 SIMAP similar genes for MT1A using alignment to 1 protein entry:     MT1A_HUMAN:
    MT1L    MT1F    MT1H    MT2A    MT1B    MT1HL1
    MT1X    MT1M    MTE    MT1E    MT1G    MT4

    MT1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MT1A (see all 98)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506111231,2
    --56671616(+) TAACTC/GGATGT 1 -- us2k10--------
    rs609008281,2
    C,F--56671632(+) TTTTTA/TATTTT 1 -- us2k14Minor allele frequency- T:0.10WA CSA NA 242
    rs1863193341,2
    --56671666(+) CTATGC/TGGACT 1 -- us2k10--------
    rs1387459981,2
    --56671673(+) GACTAC/GGCAGG 1 -- us2k10--------
    rs18466921,2
    C,F,A,H--56671696(+) GGGCTC/TAAGTG 1 -- us2k122Minor allele frequency- T:0.42NS EA NA CSA WA 2339
    rs591047021,2
    C,F--56671717(+) CTCAGC/ACTCCT 1 -- us2k13Minor allele frequency- A:0.15CSA WA NA 239
    rs18272131,2
    C,F,A--56671841(+) GAACTG/ACCAGA 1 -- us2k19Minor allele frequency- A:0.47NA WA CSA EA 369
    rs353469591,2
    C--56671867(+) CGGCTA/GGGCTG 1 -- us2k14Minor allele frequency- G:0.16NA EA 244
    rs1899231551,2
    --56671971(+) GACCCA/GTGTTC 1 -- us2k10--------
    rs561783871,2
    C,F--56672015(+) GGACCT/GAGGTG 1 -- us2k12Minor allele frequency- G:0.10NA EA 240

    HapMap Linkage Disequilibrium report for MT1A (56672578 - 56673999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MT1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669588CNV Deletion23128226
    nsv906720CNV Loss21882294

    Human Gene Mutation Database (HGMD): MT1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MT1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 156350    OMIM disorders: --

    Selected diseases for MT1A (see all 24):    
    About MalaCards
    cerebral lymphoma    keloids    lupus nephritis    pancreatic cancer
    nephritis    graves' disease    hypoxia    hepatitis c
    cerebritis    prostate cancer    basal cell carcinoma    melanoma
    pancreatitis    diabetes mellitus    ischemia    prostatitis
    retinitis    breast cancer    alzheimer's disease    hepatitis


    MT1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for MT1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 15.8 1 16274045 (1)
    shock 14 1 16039398 (1)
    breast cancer 0 1 11756227 (1)
    prostate cancer 0 2 10754528 (2)
    melanoma 0 1 10333769 (1)

    Genetic Association Database (GAD): MT1A
    Human Genome Epidemiology (HuGE) Navigator: MT1A (7 documents)

    Export disorders for MT1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT1A gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with MT1A)
        Utopia: connect your pdf to the dynamic
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    1. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. (PubMed id 6327055)1, 2, 3 Richards R.I.... Karin M. (Cell 1984)
    2. Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort. (PubMed id 19962295)1, 4 Giacconi R....Mocchegiani E. (J. Nutr. Biochem. 2010)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Genetic background of lead and mercury metabolism in a group of medical students in Austria. (PubMed id 19515364)1, 4 Gundacker C....Gencik M. (Environ. Res. 2009)
    5. +647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications. (PubMed id 18249147)1, 4 Giacconi R....Mocchegiani E. (Mol. Genet. Metab. 2008)
    6. Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications. (PubMed id 18349110)1, 4 Yang L....Liu Y. (Am. J. Physiol. Endocrinol. Metab. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (Proc. Natl. Acad. Sci. U.S.A. 1984)
    9. Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure. (PubMed id 19359654)1, 9 Chang X....Lei L. (Exp. Biol. Med. (Maywood) 2009)
    10. Metal exchange in metallothioneins: a novel structurally significant Cd(5) species in the alpha domain of human metallothionein 1a. (PubMed id 18429853)1, 9 Rigby Duncan K.E....Stillman M.J. (FEBS J. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4489 HGNC: 7393 AceView: MT1_ Ensembl:ENSG00000205362 euGenes: HUgn4489
    ECgene: MT1A H-InvDB: MT1A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT1A gene:
    Search GeneIP for patents involving MT1A

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