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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1A Gene

protein-coding   GIFtS: 53
GCID: GC16P056672

metallothionein 1A

(Previous name: metallothionein 1S )
(Previous symbols: MT1, MT1S)
 Explore 22 diseases affiliated with
MT1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MT1A    

Aliases
for MT1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metallothionein 1A1 2     MTC2
MT1S1 2 3     Metallothionein 1A (Functional)2
MT11 2     Metallothionein-1A1
Metallothionein 1S1 2     Metallothionein-IA3
MT-1A2 3     Metallothionein-IA3
MT-IA2 3     

External Ids:    HGNC: 73931   Entrez Gene: 44892   Ensembl: ENSG000002053627   OMIM: 1563505   UniProtKB: P047313   

Export aliases for MT1A gene to outside databases

Previous GC identifers: GC16P047056 GC16M056723 GC16P056405 GC16P056442 GC16P056447 GC16P055230 GC16P042542


Summaries
for MT1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1A (Metallothionein 1A)


Genomic Views
for MT1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1A gene promoter:
         TBP   p53   Sp1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MT1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MT1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056672:  view genomic region     (about GC identifiers)

Start:
 56,672,578 bp from pter      End:
 56,673,999 bp from pter
Size:
 1,422 bases      Orientation:
 plus strand

Proteins
for MT1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731 (See protein sequence)
Recommended Name: Metallothionein-1A  
Size: 61 amino acids; 6120 Da
Subunit: Monomer
Secondary accessions: Q86YX5

Explore the universe of human proteins at neXtProt for MT1A: NX_P04731

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04731

    • MT1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005937.2  
    ENSEMBL proteins: 
     ENSP00000290705  

    Human Recombinant Protein Products: 
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    Novus Biologicals MT1A Protein
    Novus Biologicals MT1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MT1A

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm NAS--
    GO:0005764lysosome ----
    GO:0005829cytosol ----
    GO:0048471perinuclear region of cytoplasm ISS--


    MT1A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MT1A

    Protein Domains /
    Families
    for MT1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MT1A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P04731

    ProtoNet protein and cluster: P04731

    UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
    the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Function
    for MT1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MT1A_HUMAN, P04731
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
    transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1A:
    metallothionein 1A cluster

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1A (see all 4)
    OriGene shRNA RFP: MT1A
    OriGene siRNA: MT1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1A

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MT1A

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding NAS--
    GO:0008270zinc ion binding NAS--
    GO:0046870cadmium ion binding NAS--


    MT1A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for MT1A: Mt1tm1Bri Mt1tm1Rch
         15/19 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mt1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  nervous system  normal  renal/urinary system  reproductive system 

    MT1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MT1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    		Platinum Pathway, Pharmacokinetics/Pharmacodynamics1.00


    1 PharmGKB Pathway for MT1A
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MT1A (P047312, 3 ENSP000002907054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPR50Q135852, 3, ENSP000002183164MINT-2836169 MINT-2836224 MINT-2836149 I2D: score=1 STRING: ENSP00000218316
    TP53P046372, 3, ENSP000002693054MINT-1781494 MINT-1781525 MINT-1781444 I2D: score=1 STRING: ENSP00000269305
    ARRB1P494072, 3, ENSP000003771414MINT-2836265 I2D: score=1 STRING: ENSP00000377141
    GNAI1P630962, 3, ENSP000003430274MINT-2836337 I2D: score=1 STRING: ENSP00000343027
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006875cellular metal ion homeostasis ----
    GO:0006882cellular zinc ion homeostasis ----
    GO:0007263nitric oxide mediated signal transduction ----
    GO:0045926negative regulation of growth ISS--
    GO:0071247cellular response to chromate ----


    MT1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MT1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT1A

    1 HMDB Compound for MT1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--
    7 Novoseek chemical compound relationships for MT1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 74.1 22 16600086 (4), 19359654 (3), 16087360 (2), 8171441 (1) (see all 7)
    2[125i]iodomelatonin 65.4 1 11123519 (1)
    cdcl2 55.1 1 1716322 (1)
    zinc 50.1 11 18316168 (2), 16087360 (2), 18321746 (1), 17468938 (1) (see all 6)
    glyceraldehyde 3-phosphate 42 1 15952643 (1)
    copper 31.5 1 9831543 (1)
    oxygen 0 1 12553033 (1)

    Search CenterWatch for drugs/clinical trials and news about MT1A 

    Transcripts
    for MT1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MT1A gene: 
    NM_005946.2  

    Unigene Cluster for MT1A:

    Metallothionein 1A
    Hs.655199  [show with all ESTs]
    Unigene Representative Sequence: BM684446
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000290705(uc002eji.3 uc002ejq.3)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MT1A (see all 4)
    OriGene shRNA RFP: MT1A
    OriGene siRNA: MT1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT1A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MT1A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MT1A (see all 2)
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    GenScript: all cDNA clones in your preferred vector: MT1A (NM_005946)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1A

    Additional cDNA sequence: 

    AY028617.1 BC029475.1 

    4 DOTS entries:

    DT.85100940  DT.97825490  DT.97862512  DT.95376032 

    24/139 AceView cDNA sequences (see all 139):

    F26333 BX113499 CB529368 F25557 T27991 AI341945 BI821822 S68956 
    CD675632 F30567 AJ712480 F27787 T29525 F30476 CD672936 CB117071 
    AI814448 X76717 BI769333 BM923250 AA973675 BM971621 AA973227 BM694421 

    GeneLoc Exon Structure


    Expression
    for MT1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTGTGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MT1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Adult human kidney epithelial cells (Primary Cell)Kidney
    Mesendoderm-like cells (Generation of mesend...)

    See MT1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT1A

    SOURCE GeneReport for Unigene cluster: Hs.655199
        SABiosciences Expression via Pathway-Focused PCR Array including MT1A: 
              Nephrotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1A

    Orthologs
    for MT1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MT1A gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MT36
    		 --
    		 74(a)
    		 1 → many
    		 GL343675.1(182526-186438)
    zebrafish
    (Danio rerio)    		 Actinopterygii mt26
    		 metallothionein 2
    		 63(a)
    		 1 → many
    		 18(17193795-17195147)


    ENSEMBL Gene Tree for MT1A (if available)
    TreeFam Gene Tree for MT1A (if available) 

    Paralogs
    for MT1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT1A gene
    MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT2A2  MT42  MT1M2  
    MT32  MT1H2  
    12 SIMAP similar genes for MT1A using alignment to 1 protein entry:     MT1A_HUMAN:
    MT1L    MT1F    MT1H    MT2A    MT1B    MT1X
    MTP    MT1M    MTE    MT1E    MT1G    MT4

    MT1A for paralogs           About GeneDecksing



    Genomic Variants
    for MT1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in MT1A are shown (see all 103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs47847011,2
    		C,F,A,H,--56670667(+) TCCTCT/GGGGTC 2 -- int1 us2k115Minor allele frequency- G:0.50NS EA NA WA CSA 789
    rs615773881,2
    		C,--56670676(+) TCTGGC/AGTCTG 2 -- us2k1 int11Minor allele frequency- A:0.50WA 2
    rs1456082651,2
    		--56670805(+) GTGCCC/TACGGC 2 -- us2k1 nc-transcript-variant0--------
    rs110761591,2
    		C,F,H,--56670827(+) AGGGAC/TGTCGG 2 -- us2k1 nc-transcript-variant10Minor allele frequency- T:0.10NS EA NA WA 768
    rs1144980361,2
    		C,F,--56670830(+) GACGTC/TGGAGA 2 -- us2k1 nc-transcript-variant1Minor allele frequency- T:0.03WA 118
    rs1381310091,2
    		--56670894(+) AACAAC/GCTGCA 2 -- nc-transcript-variantus2k10--------
    rs359880041,2
    		C,--56670909(+) CTGGAT/-TTTTT 2 -- us2k1 nc-transcript-variant1Minor allele frequency- -:0.50NA 2
    rs1409653981,2
    		--56670933(+) TGAGCC/TATTTG 2 -- nc-transcript-variantus2k10--------
    rs71968901,2
    		C,F,A,H,--56671020(+) TGTGCC/ATTGGA 2 -- us2k1 ds500117Minor allele frequency- A:0.35NS EA NA WA CSA 1988
    rs1833124891,2
    		--56671090(+) TGTGAA/GTCACT 2 -- ds5001 us2k10--------

    HapMap Linkage Disequilibrium report for MT1A (56672578 - 56673999 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT1A: --
    Human Gene Mutation Database (HGMD): MT1A

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT1A
    DNA2.0 Custom Variant and Variant Library Synthesis for MT1A

    Disorders / Diseases
    for MT1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MT1A for disorders           About GeneDecksing

    OMIM gene information: 156350    OMIM disorders: --

    20/22 diseases for MT1A (see all 22):    About MalaCards
    type 2 diabetes mellitus    diabetes mellitus    myelomonocytic leukemia    lupus nephritis
    nephritis    cerebral lymphoma    keloids    hepatitis c
    pancreatic cancer    prostate cancer    breast cancer    alzheimer's disease
    cerebritis    pancreatitis    melanoma    prostatitis
    ischemia    hepatitis    leukemia    hypoxia

    5 Novoseek disease relationships for MT1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 15.8 1 16274045 (1)
    shock 14 1 16039398 (1)
    breast cancer 0 1 11756227 (1)
    prostate cancer 0 2 10754528 (2)
    melanoma 0 1 10333769 (1)

    Human Genome Epidemiology (HuGE) Navigator: MT1A (7 documents)

    Export disorders for MT1A gene to outside databases

    Publications
    for MT1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT1A gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with MT1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. (PubMed id 6327055)1, 2, 3 Richards R.I....Karin M. (1984)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (1984)
    4. Metallothionein I isoform mRNA expression in peripher al lymphocytes as a biomarker for occupational cadmium exposure. (PubMed id 19359654)1, 9 Chang X....Lei L. (2009)
    5. Metal exchange in metallothioneins: a novel structurally significant Cd(5) species in the alpha domain of human metallothionein 1a. (PubMed id 18429853)1, 9 Rigby Duncan K.E....Stillman M.J. (2008)
    6. Effect of metallothionein on cell viability and its interactions with cadmium and zinc in HEK293 cells. (PubMed id 16087360)1, 9 Li J....Ru B. (2005)
    7. Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. (PubMed id 10754528)1, 9 Garrett S.H....Sens D.A. (2000)
    8. Noncooperative cadmium(II) binding to human metallothionein 1a. (PubMed id 18533113)1, 9 Sutherland D.E. and Stillman M.J. (2008)
    9. Effects of interleukin-6 -174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing. (PubMed id 18316168)1, 9 Mazzatti D.J....Mocchegiani E. (2008)
    10. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PubMed id 16827180)1, 9 Chang X.L....Zhou Y.F. (2006)

    External Searches for MT1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MT1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4489 HGNC: 7393 AceView: MT1_ Ensembl:ENSG00000205362 euGenes: HUgn4489
    ECgene: MT1A H-InvDB: MT1A

    Other Databases showing MT1A gene

    (According to HUGE)
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    Specialized Databases showing MT1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MT1A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MT1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for MT1A gene:
    Search GeneIP for patents involving MT1A

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