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Aliases for MT1A Gene

Aliases for MT1A Gene

  • Metallothionein 1A 2 3
  • Metallothionein 1S 2 3
  • Metallothionein-IA 3 4
  • MT-1A 3 4
  • MT-IA 3 4
  • MT1S 3 4
  • Metallothionein 1A (Functional) 3
  • MTC 3
  • MT1 3

External Ids for MT1A Gene

Previous HGNC Symbols for MT1A Gene

  • MT1
  • MT1S

Previous GeneCards Identifiers for MT1A Gene

  • GC16P047056
  • GC16M056723
  • GC16P056405
  • GC16P056442
  • GC16P056447
  • GC16P055230
  • GC16P056672
  • GC16P042542

Summaries for MT1A Gene

GeneCards Summary for MT1A Gene

MT1A (Metallothionein 1A) is a Protein Coding gene. Among its related pathways are Mineral absorption and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1A Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1A Gene

Genomics for MT1A Gene

Regulatory Elements for MT1A Gene

Transcription factor binding sites by QIAGEN in the MT1A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MT1A Gene

Chromosome:
16
Start:
56,638,666 bp from pter
End:
56,750,276 bp from pter
Size:
111,611 bases
Orientation:
Plus strand

Genomic View for MT1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1A Gene

Proteins for MT1A Gene

  • Protein details for MT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04731-MT1A_HUMAN
    Recommended name:
    Metallothionein-1A
    Protein Accession:
    P04731
    Secondary Accessions:
    • Q86YX5

    Protein attributes for MT1A Gene

    Size:
    61 amino acids
    Molecular mass:
    6120 Da
    Quaternary structure:
    • Monomer

neXtProt entry for MT1A Gene

Proteomics data for MT1A Gene at MOPED

Post-translational modifications for MT1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MT1A Gene

Domains & Families for MT1A Gene

Gene Families for MT1A Gene

Suggested Antigen Peptide Sequences for MT1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04731

UniProtKB/Swiss-Prot:

MT1A_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1A: view

Function for MT1A Gene

Molecular function for MT1A Gene

GENATLAS Biochemistry:
metallothionein 1A cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16442532
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT1A: view
genes like me logo Genes that share phenotypes with MT1A: view

Animal Models for MT1A Gene

MGI Knock Outs for MT1A:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MT1A Gene

Localization for MT1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1A Gene COMPARTMENTS Subcellular localization image for MT1A gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1A Gene

Pathways & Interactions for MT1A Gene

genes like me logo Genes that share pathways with MT1A: view

Pathways by source for MT1A Gene

1 PharmGKB pathway for MT1A Gene
1 KEGG pathway for MT1A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nephrotoxicity in human,mouse,rat

Gene Ontology (GO) - Biological Process for MT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045926 negative regulation of growth ISS --
GO:0071276 cellular response to cadmium ion IEP 16827180
GO:0071294 cellular response to zinc ion IEP 11168427
genes like me logo Genes that share ontologies with MT1A: view

No data available for SIGNOR curated interactions for MT1A Gene

Drugs & Compounds for MT1A Gene

(7) Drugs for MT1A Gene - From: NovoSeek, FDA Approved Drugs, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1276
Agomelatine Approved, Investigational Pharma Antagonist MT1/MT2 / 5-HT2C agonist 0
Eloxatin Approved August 2002 Pharma 0

(5) Additional Compounds for MT1A Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
2[125I]iodomelatonin
cdcl2
glyceraldehyde 3-phosphate
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with MT1A: view

Transcripts for MT1A Gene

mRNA/cDNA for MT1A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MT1A Gene

Metallothionein 1A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1A Gene

No ASD Table

Relevant External Links for MT1A Gene

GeneLoc Exon Structure for
MT1A
ECgene alternative splicing isoforms for
MT1A

Expression for MT1A Gene

mRNA expression in normal human tissues for MT1A Gene

mRNA differential expression in normal tissues according to GTEx for MT1A Gene

This gene is overexpressed in Liver (x10.8) and Adipose - Visceral (Omentum) (x6.7).

Protein differential expression in normal tissues from HIPED for MT1A Gene

This gene is overexpressed in Liver (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MT1A Gene



SOURCE GeneReport for Unigene cluster for MT1A Gene Hs.655199

genes like me logo Genes that share expression patterns with MT1A: view

Protein tissue co-expression partners for MT1A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MT1A Gene

Orthologs for MT1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mt1 16
Mt1 36
  • 82 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia MT1E 36
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia MT1A 36
  • 98 (a)
OneToOne
Species with no ortholog for MT1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1A Gene

ENSEMBL:
Gene Tree for MT1A (if available)
TreeFam:
Gene Tree for MT1A (if available)

Paralogs for MT1A Gene

Paralogs for MT1A Gene

(12) SIMAP similar genes for MT1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT1A: view

Variants for MT1A Gene

Sequence variations from dbSNP and Humsavar for MT1A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs904776 -- 56,640,239(-) CAGGT(A/G)CCTGA downstream-variant-500B
rs904777 -- 56,640,199(-) AATAG(C/G)ACAAG downstream-variant-500B
rs1827213 -- 56,637,929(+) GAACT(A/G)CCAGA upstream-variant-2KB
rs1846692 -- 56,637,784(+) GGGCT(C/T)AAGTG upstream-variant-2KB
rs4784702 -- 56,640,570(+) CTTGG(C/T)CTGTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MT1A Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
esv2669588 CNV Deletion 23128226

Variation tolerance for MT1A Gene

Residual Variation Intolerance Score: 61.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.59; 93.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT1A Gene

HapMap Linkage Disequilibrium report
MT1A
Human Gene Mutation Database (HGMD)
MT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1A Gene

Disorders for MT1A Gene

Relevant External Links for MT1A

Genetic Association Database (GAD)
MT1A
Human Genome Epidemiology (HuGE) Navigator
MT1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT1A
genes like me logo Genes that share disorders with MT1A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1A Gene

Publications for MT1A Gene

  1. Metallothionein-1 isoforms and vimentin are direct PU.1 downstream target genes in leukemia cells. (PMID: 20139074) Imoto A. … Takahashi S. (J. Biol. Chem. 2010) 23 67
  2. Development of an enzyme-linked immunosorbent assay for metallothionein-I and -II in plasma of humans and experimental animals. (PMID: 20184868) Nakajima K. … Nagamine T. (Clin. Chim. Acta 2010) 23 67
  3. Supermetalation of the beta domain of human metallothionein 1a. (PMID: 20329713) Sutherland D.E. … Stillman M.J. (Biochemistry 2010) 23 67
  4. Zinc homeostasis in pediatric critical illness. (PMID: 19057435) Cvijanovich N.Z. … Wong H.R. (Pediatr Crit Care Med 2009) 23 67
  5. Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure. (PMID: 19359654) Chang X. … Lei L. (Exp. Biol. Med. (Maywood) 2009) 23 67

Products for MT1A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Nephrotoxicity in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MT1A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MT1A
    • Block miRNA regulation of MT1A using miScript Target Protectors

    Sources for MT1A Gene

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