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Aliases for MT-TW Gene

Subcategory (RNA class) for MT-TW Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MT-TW Gene

  • Mitochondrially Encoded TRNA Tryptophan 2 5
  • TRNA Tryptophan 2
  • TRNA 3
  • TRNW 3
  • MTTW 3

External Ids for MT-TW Gene

Previous HGNC Symbols for MT-TW Gene

  • MTTW

Previous GeneCards Identifiers for MT-TW Gene

  • GC00U921616

Summaries for MT-TW Gene

GeneCards Summary for MT-TW Gene

MT-TW (Mitochondrially Encoded TRNA Tryptophan) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TW include Mitochondrial Disorders and Combined Oxidative Phosphorylation Deficiency 8. Among its related pathways are tRNA Aminoacylation.

Additional gene information for MT-TW Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TW Gene

Genomics for MT-TW Gene

Genomic Location for MT-TW Gene

Chromosome:
MT
Start:
5,512 bp from pter
End:
5,579 bp from pter
Size:
68 bases
Orientation:
Plus strand

Genomic View for MT-TW Gene

Genes around MT-TW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TW Gene

No data available for Regulatory Elements for MT-TW Gene

Proteins for MT-TW Gene

Post-translational modifications for MT-TW Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TW Gene

Domains & Families for MT-TW Gene

Gene Families for MT-TW Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TW: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TW Gene

Function for MT-TW Gene

Human Phenotype Ontology for MT-TW Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MT-TW
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TW Gene

Localization for MT-TW Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT-TW gene
Compartment Confidence
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MT-TW Gene

Pathways & Interactions for MT-TW Gene

SuperPathways for MT-TW Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TW: view

Pathways by source for MT-TW Gene

1 KEGG pathway for MT-TW Gene

Interacting Proteins for MT-TW Gene

Gene Ontology (GO) - Biological Process for MT-TW Gene

None

No data available for SIGNOR curated interactions for MT-TW Gene

Drugs & Compounds for MT-TW Gene

No Compound Related Data Available

Transcripts for MT-TW Gene

mRNA/cDNA for MT-TW Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MT-TW
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TW Gene

No ASD Table

Relevant External Links for MT-TW Gene

GeneLoc Exon Structure for
MT-TW
ECgene alternative splicing isoforms for
MT-TW

Expression for MT-TW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT-TW Gene

Phenotype-based relationships between genes and organs from Gene ORGANizer for MT-TW Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • meninges
  • neck
Thorax:
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • kidney
  • liver
  • pancreas
  • stomach
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with MT-TW: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MT-TW Gene

Orthologs for MT-TW Gene

Evolution for MT-TW Gene

ENSEMBL:
Gene Tree for MT-TW (if available)
TreeFam:
Gene Tree for MT-TW (if available)

No data available for Orthologs for MT-TW Gene

Paralogs for MT-TW Gene

No data available for Paralogs for MT-TW Gene

Variants for MT-TW Gene

Relevant External Links for MT-TW Gene

Human Gene Mutation Database (HGMD)
MT-TW
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT-TW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TW Gene

Disorders for MT-TW Gene

MalaCards: The human disease database

(8) MalaCards diseases for MT-TW Gene - From: HGMD, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial disorders
  • mitochondrial encephalomyopathies
combined oxidative phosphorylation deficiency 8
  • mitochondrial myopathies
mitochondrial encephalomyopathy
  • mitochondrial encephalomyopathies
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes
  • melas syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MT-TW in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MT-TW: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for MT-TW Gene

Publications for MT-TW Gene

  1. Trp (PMID: 27687549) Guo L … Bi R (Biochemical and biophysical research communications 2016) 3 60
  2. A mutation in MT-TW causes a tRNA processing defect and reduced mitochondrial function in a family with Leigh syndrome. (PMID: 26524491) Duff RM … Filipovska A (Mitochondrion 2015) 3 60
  3. MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease. (PMID: 19758471) Bhardwaj A … Tiwari S (BMC bioinformatics 2009) 3 60
  4. Two new mutations in the MT-TW gene leading to the disruption of the secondary structure of the tRNA(Trp) in patients with Leigh syndrome. (PMID: 19349200) Mkaouar-Rebai E … Fakhfakh F (Molecular genetics and metabolism 2009) 3 60

Products for MT-TW Gene

Sources for MT-TW Gene

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