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Mitochondrially Encoded TRNA Threonine(Previous name: tRNA threonine)
(Previous symbol: MTTT)
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Aliases
for MT-TT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
Subcategory (RNA class): Mt_tRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Mitochondrially Encoded TRNA Threonine1 | | MTTT1 2 | | TRNA Threonine1 | | TRNT2 | | tRNA2 |
Export aliases for MT-TT gene to outside databasesPrevious GC identifer: GC00U921614 |
Summaries
for MT-TT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for MT-TT Gene: 
MT-TT (mitochondrially encoded tRNA threonine) is an RNA gene, and is affiliated with the Mt_tRNA class. Diseases associated with MT-TT include lethal infantile mitochondrial myopathy, and infantile myopathy and lactic acidosis, and among its related super-pathways are tRNA Aminoacylation.
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Genomic Views
for MT-TT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MT-TT
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT-TT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-TT |
Genomic Location:
Chromosome:MT
Ensembl cytogenetic band: MT HGNC chromosome: mitochondriaGeneLoc information about chromosome MT GeneLoc Exon Structure GeneLoc location for GCMTP015890:
(about GC identifiers)
Start:
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15,888 bp from pter |
End:
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15,953 bp from pter |
Size:
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66 bases |
Orientation:
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plus strand |
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Proteins
for MT-TT gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB: --
|
Protein
Domains /
Families
for MT-TT gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
MTTRNA: ncRNAs / Transfer RNA, mitochondrial
-- |
Function
for MT-TT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MT-TT | |  | Search LifeMap BioReagents cell lines for MT-TT | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT |
Pathways & Interactions
for MT-TT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
SuperPaths for MT-TT About  See pathways by source
| SuperPath | Contained pathways About |
|---|
| 1 | tRNA Aminoacylation | |
Pathways by source See SuperPaths
Show all pathways
1 
Kegg Pathway (Kegg details for MT-TT):
MT-TT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-TT
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Drugs & Compounds
for MT-TT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MT-TT
Search CenterWatch for drugs/clinical trials and news about MT-TT
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Transcripts
for MT-TT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000387460(Mt_tRNA)
GeneLoc Exon Structure
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Expression
for MT-TT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MT-TT:none
MT-TT expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MT-TT
Primer
Products: |  | Browse OriGene qPCR
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MT-TT | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-TT | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-TT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT |
Orthologs
for MT-TT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for MT-TT (if available)
TreeFam Gene Tree for MT-TT (if available) |
Paralogs
for MT-TT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MT-TT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): MT-TT
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MT-TT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OMIM gene information: 590090
OMIM disorders: --
6  diseases for MT-TT: About MalaCardslethal infantile mitochondrial myopathy infantile myopathy and lactic acidosis mitochondrial disorders leber hereditary optic neuropathy
neuropathy colorectal cancer
MT-TT for disorders About GeneDecksing
GeneTests: MT-TT
GeneReviews: MT-TT
Genetic Association Database (GAD): MT-TT
Export disorders for MT-TT gene to outside databases
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Publications
for MT-TT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MT-TT gene integrated from 9 sources:
(articles sorted by number of sources associating them with MT-TT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes. (PubMed id 14680844)1, 4 Momiyama Y....Matsuoka R. (2003)
- [The mitochondrial tRNA(Thr) A15951G mutation may be associated with Leber's hereditary optic neuropathy in two Chinese families]. (PubMed id 21983721)1 Zhang Y....Guan M.X. (2011)
- Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. (PubMed id 19050702)1 Webb E....Houlston R.S. (2008)
- Mitochondrial Disorders Ove rview (PubMed id 20301403)1 Chinnery P.F. (1993)
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External Searches for MT-TT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MT-TT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MT-TT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT-TT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MT-TT | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MT-TT gene:
Search GeneIP for patents involving MT-TT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MT-TT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT-TT | | | Search QIAGEN SeqTarget long-range PCR primers for resequencing in MT-TT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-TT | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT-TT | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-TT | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-TT |
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 |  |  |  | |
| | | | Search Tocris compounds for MT-TT |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MT-TT |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-TT |
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