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MT-TT Gene

RNA gene   GIFtS: 20
GCID: GCMTP015890

Mitochondrially Encoded TRNA Threonine

(Previous names: tRNA threonine, lethal infantile mitochondrial myopathy)
(Previous symbols: MTTT, LIMM)
  See MT-TT-related diseases
at
MalaCards
 

Aliases
for MT-TT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): Mt_tRNA

Quality score for this RNA gene is 3

Aliases
Mitochondrially Encoded TRNA Threonine1     TRNA Threonine1
MTTT1 2     TRNT2
LIMM1     tRNA2
Lethal Infantile Mitochondrial Myopathy1     

External Ids:    HGNC: 74991   Entrez Gene: 45762   Ensembl: ENSG000002101957   OMIM: 5900905   

Export aliases for MT-TT gene to outside databases

Previous GC identifer: GC00U921614


Summaries
for MT-TT gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-TT Gene:
MT-TT (mitochondrially encoded tRNA threonine) is an RNA gene, and is affiliated with the Mt_tRNA class. Diseases associated with MT-TT include lethal infantile mitochondrial myopathy, and infantile myopathy and lactic acidosis.


Genomic Views
for MT-TT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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TryGeneCards Plus		 Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-TT
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-TT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-TT


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP015890:       (about GC identifiers)

Start:
 15,888 bp from pter      End:
 15,953 bp from pter
Size:
 66 bases      Orientation:
 plus strand

Proteins
for MT-TT gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB: --

Domains /
Families
for MT-TT gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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TryGeneCards Plus		 HGNC Gene Families:
MTTRNA: ncRNAs / Transfer RNA, mitochondrial

  --

Function
for MT-TT gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for MT-TT

miRNA
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Inhib. RNA
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In Situ Assay
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Localization
for MT-TT gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Pathways & Interactions
for MT-TT gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MT-TT About    
See pathways by source

      Powered
by		     
SuperPathContained pathways About
1tRNA Aminoacylation
Aminoacyl-tRNA biosynthesis0.52


Find genes that share SuperPaths with MT-TT           About GenesLikeMe

Pathways by source                                   See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for MT-TT):
    Aminoacyl-tRNA biosynthesis

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-TT
Interactions:

    Search GeneGlobe Interaction Network for MT-TT

Drugs & Compounds
for MT-TT gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MT-TT



Transcripts
for MT-TT gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000387460(Mt_tRNA)
miRNA
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Inhib. RNA
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Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer
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GeneLoc Exon Structure


Expression
for MT-TT gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MT-TT:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MT-TT Protein expression data from MOPED1, PaxDb2 and MaxQB3:  --
    Custom PCR Arrays for MT-TT
Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT

Orthologs
for MT-TT gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for MT-TT (if available)
TreeFam Gene Tree for MT-TT (if available)

Paralogs
for MT-TT gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Genomic Variants
for MT-TT gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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TryGeneCards Plus		Human Gene Mutation Database (HGMD): MT-TT
Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for MT-TT

Disorders / Diseases
for MT-TT gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TryGeneCards Plus		 OMIM gene information: 590090    OMIM disorders: --

3 diseases for MT-TT:    
About MalaCards
lethal infantile mitochondrial myopathy    infantile myopathy and lactic acidosis    mitochondrial disorders


Find genes that share disorders with MT-TT           About GenesLikeMe

GeneTests: MT-TT
GeneReviews: MT-TT
Genetic Association Database (GAD): MT-TT

Export disorders for MT-TT gene to outside databases

Publications
for MT-TT gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MT-TT gene integrated from 10 sources:
(articles sorted by number of sources associating them with MT-TT)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes. (PubMed id 14680844)1, 4 Momiyama Y....Matsuoka R. (Biochem. Biophys. Res. Commun. 2003)
  2. [The mitochondrial tRNA(Thr) A15951G mutation may be associated with Leber's hereditary optic neuropathy in two Chinese families]. (PubMed id 21983721)1 Zhang Y....Guan M.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2011)
  3. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. (PubMed id 19050702)1 Webb E....Houlston R.S. (Br. J. Cancer 2008)
  4. Mitochondrial Disorders Overview (PubMed id 20301403)1 Pagon R.A....Stephens K. (1993)

External Searches for MT-TT gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MT-TT gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4576 HGNC: 7499 Ensembl:ENSG00000210195 euGenes: HUgn4576 ECgene: MT-TT Kegg: 4576
H-InvDB: MT-TT

Other Databases showing MT-TT gene

(According to HUGE)
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Specialized Databases showing MT-TT gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MT-TT Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MT-TT gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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TryGeneCards Plus		Patent Information for MT-TT gene:
Search GeneIP for patents involving MT-TT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MT-TT gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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