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Mitochondrially Encoded TRNA Threonine(Previous names: tRNA threonine, lethal infantile mitochondrial myopathy)
(Previous symbols: MTTT, LIMM)
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Aliases
for MT-TT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
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Subcategory (RNA class): Mt_tRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Mitochondrially Encoded TRNA Threonine1 | | TRNA Threonine1 | | MTTT1 2 | | TRNT2 | | LIMM1 | | tRNA2 | | Lethal Infantile Mitochondrial Myopathy1 | | |
Export aliases for MT-TT gene to outside databasesPrevious GC identifer: GC00U921614 |
Summaries
for MT-TT gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for MT-TT Gene:
MT-TT (mitochondrially encoded tRNA threonine) is an RNA gene, and is affiliated with the Mt_tRNA class. Diseases associated with MT-TT include lethal infantile mitochondrial myopathy, and infantile myopathy and lactic acidosis.
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Genomic Views
for MT-TT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for MT-TT
Other transcription factors
Search Chromatin IP Primers for MT-TT
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-TT |
Genomic Location:
Chromosome:MT
Ensembl cytogenetic band: MT HGNC chromosome: mitochondriaGeneLoc information about chromosome MT GeneLoc Exon Structure GeneLoc location for GCMTP015890:
(about GC identifiers)
Start:
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15,888 bp from pter |
End:
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15,953 bp from pter |
Size:
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66 bases |
Orientation:
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plus strand |
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Proteins
for MT-TT gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB: --
|
Domains /
Families
for MT-TT gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
MTTRNA: ncRNAs / Transfer RNA, mitochondrial
-- |
Function
for MT-TT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | Browse OriGene RNAi
| | | Predesigned siRNA for gene silencing in human, mouse, rat MT-TT |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MT-TT | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for MT-TT  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT |
Localization
for MT-TT gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Pathways & Interactions
for MT-TT gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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SuperPaths for MT-TT About  See pathways by source
Pathways by source See SuperPaths
Show all pathways
1  Kegg Pathway (Kegg details for MT-TT):
MT-TT for pathways About GeneDecksing
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-TT
Interactions:
Search GeneGlobe Interaction Network for MT-TT
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Drugs & Compounds
for MT-TT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for MT-TT
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Transcripts
for MT-TT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000387460(Mt_tRNA)
Inhib. RNA
Products: | | Browse OriGene RNAi
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat MT-TT |
GeneLoc Exon Structure
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Expression
for MT-TT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | Expression evidence for MT-TT:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
MT-TT Protein expression data from MOPED1, PaxDb2 and
MaxQB3: --
Custom PCR Arrays for MT-TT
Primer
Products: | | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MT-TT | | | QuantiTect SYBR Green Assays in human, mouse, rat MT-TT | | | QuantiFast Probe-based Assays in human, mouse, rat MT-TT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT |
Orthologs
for MT-TT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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--
ENSEMBL Gene Tree for MT-TT (if available)
TreeFam Gene Tree for MT-TT (if available) |
Paralogs
for MT-TT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for MT-TT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
TryGeneCards Plus | Human Gene Mutation Database (HGMD): MT-TT
| | Site Specific Mutation Identification with PCR Assays |
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Disorders
/ Diseases
for MT-TT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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OMIM gene information: 590090
OMIM disorders: --
8  diseases for MT-TT: About MalaCardslethal infantile mitochondrial myopathy infantile myopathy and lactic acidosis mitochondrial disorders leber hereditary optic neuropathy
lactic acidosis myopathy neuropathy colorectal cancer
MT-TT for disorders About GeneDecksing
GeneTests: MT-TT
GeneReviews: MT-TT
Genetic Association Database (GAD): MT-TT
Export disorders for MT-TT gene to outside databases
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Publications
for MT-TT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for MT-TT gene integrated from 10 sources:
(articles sorted by number of sources associating them with MT-TT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes. (PubMed id 14680844)1, 4 Momiyama Y....Matsuoka R. (Biochem. Biophys. Res. Commun. 2003)
- [The mitochondrial tRNA(Thr) A15951G mutation may be associated with Leber's hereditary optic neuropathy in two Chinese families]. (PubMed id 21983721)1 Zhang Y....Guan M.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2011)
- Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. (PubMed id 19050702)1 Webb E....Houlston R.S. (Br. J. Cancer 2008)
- Mitochondrial Disorders Overview (PubMed id 20301403)1 Pagon R.A....Stephens K. (1993)
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External Searches for MT-TT gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MT-TT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing MT-TT gene
(According to HUGE)
About This Section
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Specialized Databases showing MT-TT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MT-TT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for MT-TT gene:
Search GeneIP for patents involving MT-TT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MT-TT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | Block miRNA regulation of human, mouse, rat MT-TT using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing MT-TT | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-TT | | Predesigned siRNA for gene silencing in human, mouse, rat MT-TT | | | QuantiFast Probe-based Assays in human, mouse, rat MT-TT | | QuantiTect SYBR Green Assays in human, mouse, rat MT-TT | | | Custom PCR Arrays for MT-TT | | Search Chromatin IP Primers for MT-TT | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MT-TT | | Search GeneGlobe Interaction Network for MT-TT | | | Search Regulatory tfbs for MT-TT |
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| | | Search Tocris compounds for MT-TT |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-TT |
| |  |  |  |  | | | Search ThermoFisher Antibodies for MT-TT |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-TT |
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