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Aliases for MT-TL2 Gene

Subcategory (RNA class) for MT-TL2 Gene


Quality Score for this RNA gene is


Aliases for MT-TL2 Gene

  • Mitochondrially Encoded TRNA Leucine 2 (CUN) 2
  • TRNA Leucine 2 (CUN) 2
  • TRNL2 3
  • MTTL2 3
  • TRNA 3

External Ids for MT-TL2 Gene

Previous HGNC Symbols for MT-TL2 Gene

  • MTTL2

Previous GeneCards Identifiers for MT-TL2 Gene

  • GC00U921606

Summaries for MT-TL2 Gene

GeneCards Summary for MT-TL2 Gene

MT-TL2 (Mitochondrially Encoded TRNA Leucine 2 (CUN)) is an RNA Gene, and is affiliated with the Mt_tRNA class. Diseases associated with MT-TL2 include chronic progressive external ophthalmoplegia and kearns-sayre syndrome. Among its related pathways are tRNA Aminoacylation.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TL2 Gene

Genomics for MT-TL2 Gene

Genomic Location for MT-TL2 Gene

12,266 bp from pter
12,336 bp from pter
71 bases
Plus strand

Genomic View for MT-TL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for MT-TL2 Gene

No data available for Regulatory Elements for MT-TL2 Gene

Proteins for MT-TL2 Gene

Post-translational modifications for MT-TL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TL2 Gene

Domains for MT-TL2 Gene

Gene Families for MT-TL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TL2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TL2 Gene

Function for MT-TL2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TL2 Gene

Localization for MT-TL2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MT-TL2 Gene

Pathways for MT-TL2 Gene

SuperPathways for MT-TL2 Gene

Superpath Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TL2: view

Pathways by source for MT-TL2 Gene

1 KEGG pathway for MT-TL2 Gene

Interacting Proteins for MT-TL2 Gene

Gene Ontology (GO) - Biological Process for MT-TL2 Gene


Transcripts for MT-TL2 Gene

mRNA/cDNA for MT-TL2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TL2 Gene

No ASD Table

Relevant External Links for MT-TL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-TL2 Gene

mRNA expression in normal human tissues for MT-TL2 Gene

mRNA differential expression in normal tissues according to GTEx for MT-TL2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (6.5), Brain - Putamen (basal ganglia) (6.5), and Brain - Substantia nigra (5.8).
genes like me logo Genes that share expressions with MT-TL2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MT-TL2 Gene

Orthologs for MT-TL2 Gene

Evolution for MT-TL2 Gene

Gene Tree for MT-TL2 (if available)
Gene Tree for MT-TL2 (if available)

No data available for Orthologs for MT-TL2 Gene

Paralogs for MT-TL2 Gene

No data available for Paralogs for MT-TL2 Gene

Variants for MT-TL2 Gene

Relevant External Links for MT-TL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MT-TL2 Gene

Disorders for MT-TL2 Gene

Relevant External Links for MT-TL2

genes like me logo Genes that share disorders with MT-TL2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MT-TL2 Gene

Publications for MT-TL2 Gene

  1. Genotyping Parkinson disease-associated mitochondrial polymorphisms. (PMID: 15931342) Jiang Y. … Greenlee A.R. (Clin Med Res 2004) 3
  2. Increased risk of oral cancer in relation to common Indian mitochondrial polymorphisms and Autosomal GSTP1 locus. (PMID: 17886251) Datta S. … Roy B. (Cancer 2007) 3
  3. Chronic progressive external ophthalmoplegia: a new heteroplasmic tRNA(Leu(CUN)) mutation of mitochondrial DNA. (PMID: 18603265) Cardaioli E. … Federico A. (J. Neurol. Sci. 2008) 3
  4. Mitochondrial DNA variant interactions modify breast cancer risk. (PMID: 18709563) Covarrubias D. … Leal S.M. (J. Hum. Genet. 2008) 3
  5. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. (PMID: 19050702) Webb E. … Houlston R.S. (Br. J. Cancer 2008) 3

Products for MT-TL2 Gene

Sources for MT-TL2 Gene

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