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Aliases for MT-TL2 Gene

Subcategory (RNA class) for MT-TL2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MT-TL2 Gene

  • Mitochondrially Encoded TRNA Leucine 2 (CUN) 2 5
  • TRNA Leucine 2 (CUN) 2
  • TRNL2 3
  • MTTL2 3
  • TRNA 3

External Ids for MT-TL2 Gene

Previous HGNC Symbols for MT-TL2 Gene

  • MTTL2

Previous GeneCards Identifiers for MT-TL2 Gene

  • GC00U921606

Summaries for MT-TL2 Gene

GeneCards Summary for MT-TL2 Gene

MT-TL2 (Mitochondrially Encoded TRNA Leucine 2 (CUN)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TL2 include mitochondrial disorders and kearns-sayre syndrome. Among its related pathways are tRNA Aminoacylation.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TL2 Gene

Genomics for MT-TL2 Gene

Genomic Location for MT-TL2 Gene

Chromosome:
MT
Start:
12,266 bp from pter
End:
12,336 bp from pter
Size:
71 bases
Orientation:
Plus strand

Genomic View for MT-TL2 Gene

Genes around MT-TL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TL2 Gene

No data available for Regulatory Elements for MT-TL2 Gene

Proteins for MT-TL2 Gene

Post-translational modifications for MT-TL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TL2 Gene

Domains & Families for MT-TL2 Gene

Gene Families for MT-TL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TL2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TL2 Gene

Function for MT-TL2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TL2 Gene

Localization for MT-TL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-TL2 Gene COMPARTMENTS Subcellular localization image for MT-TL2 gene
Compartment Confidence
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MT-TL2 Gene

Pathways & Interactions for MT-TL2 Gene

SuperPathways for MT-TL2 Gene

Superpath Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TL2: view

Pathways by source for MT-TL2 Gene

1 KEGG pathway for MT-TL2 Gene

Interacting Proteins for MT-TL2 Gene

Gene Ontology (GO) - Biological Process for MT-TL2 Gene

None

No data available for SIGNOR curated interactions for MT-TL2 Gene

Drugs & Compounds for MT-TL2 Gene

No Compound Related Data Available

Transcripts for MT-TL2 Gene

mRNA/cDNA for MT-TL2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TL2 Gene

No ASD Table

Relevant External Links for MT-TL2 Gene

GeneLoc Exon Structure for
MT-TL2
ECgene alternative splicing isoforms for
MT-TL2

Expression for MT-TL2 Gene

mRNA expression in normal human tissues for MT-TL2 Gene

mRNA differential expression in normal tissues according to GTEx for MT-TL2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.5), and Brain - Substantia nigra (x5.8).
genes like me logo Genes that share expression patterns with MT-TL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MT-TL2 Gene

Orthologs for MT-TL2 Gene

Evolution for MT-TL2 Gene

ENSEMBL:
Gene Tree for MT-TL2 (if available)
TreeFam:
Gene Tree for MT-TL2 (if available)

No data available for Orthologs for MT-TL2 Gene

Paralogs for MT-TL2 Gene

No data available for Paralogs for MT-TL2 Gene

Variants for MT-TL2 Gene

Relevant External Links for MT-TL2 Gene

HapMap Linkage Disequilibrium report
MT-TL2
Human Gene Mutation Database (HGMD)
MT-TL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TL2 Gene

Disorders for MT-TL2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MT-TL2 Gene - From: ClinVar, GeneTests, and Orphanet

Disorder Aliases PubMed IDs
mitochondrial disorders
  • mitochondrial encephalomyopathies
kearns-sayre syndrome
  • mitochondrial myopathies
maternally-inherited progressive external ophthalmoplegia
  • maternally-inherited cpeo
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MT-TL2: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for MT-TL2 Gene

Publications for MT-TL2 Gene

  1. Clinical and cellular consequences of the mutation m.12300G>A in the mitochondrial tRNA(Leu(CUN)) gene. (PMID: 22094595) MartA-n-JimAcnez R. … Campos Y. (Mitochondrion 2012) 3 67
  2. Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations. (PMID: 20064630) Nishigaki Y. … Tanaka M. (Mitochondrion 2010) 3
  3. Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. (PMID: 20111055) Kato T. … Tanaka M. (J. Hum. Genet. 2010) 3
  4. Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. (PMID: 20538375) Lakatos A. … Potkin S.G. (Neurobiol. Aging 2010) 3
  5. [Study on the mitochondrial DNA mutations in familial diabetes mellitus in Chinese population]. (PMID: 19199242) Wang S.J. … Xiang K.S. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009) 3

Products for MT-TL2 Gene

Sources for MT-TL2 Gene

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