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Aliases for MT-TK Gene

Subcategory (RNA class) for MT-TK Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for MT-TK Gene

  • Mitochondrially Encoded TRNA Lysine 2 5
  • TRNA Lysine 2
  • TRNA 3
  • TRNK 3
  • MTTK 3

External Ids for MT-TK Gene

Previous HGNC Symbols for MT-TK Gene

  • MTTK

Previous GeneCards Identifiers for MT-TK Gene

  • GC00U921604

Summaries for MT-TK Gene

GeneCards Summary for MT-TK Gene

MT-TK (Mitochondrially Encoded TRNA Lysine) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TK include Merrf Syndrome and Maternally Inherited Diabetes And Deafness. Among its related pathways are tRNA Aminoacylation.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TK Gene

Genomics for MT-TK Gene

Genomic Location for MT-TK Gene

8,295 bp from pter
8,364 bp from pter
70 bases
Plus strand

Genomic View for MT-TK Gene

Genes around MT-TK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TK Gene

No data available for Regulatory Elements for MT-TK Gene

Proteins for MT-TK Gene

Post-translational modifications for MT-TK Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TK Gene

Domains & Families for MT-TK Gene

Gene Families for MT-TK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TK: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TK Gene

Function for MT-TK Gene

Human Phenotype Ontology for MT-TK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TK Gene

Localization for MT-TK Gene

Subcellular locations from

Jensen Localization Image for MT-TK Gene COMPARTMENTS Subcellular localization image for MT-TK gene
Compartment Confidence
chloroplast 3
mitochondrion 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MT-TK Gene

Pathways & Interactions for MT-TK Gene

SuperPathways for MT-TK Gene

Superpath Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TK: view

Pathways by source for MT-TK Gene

1 KEGG pathway for MT-TK Gene

Interacting Proteins for MT-TK Gene

Gene Ontology (GO) - Biological Process for MT-TK Gene


No data available for SIGNOR curated interactions for MT-TK Gene

Drugs & Compounds for MT-TK Gene

No Compound Related Data Available

Transcripts for MT-TK Gene

mRNA/cDNA for MT-TK Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TK Gene

No ASD Table

Relevant External Links for MT-TK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-TK Gene

mRNA expression in normal human tissues for MT-TK Gene

genes like me logo Genes that share expression patterns with MT-TK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MT-TK Gene

Orthologs for MT-TK Gene

Evolution for MT-TK Gene

Gene Tree for MT-TK (if available)
Gene Tree for MT-TK (if available)

No data available for Orthologs for MT-TK Gene

Paralogs for MT-TK Gene

No data available for Paralogs for MT-TK Gene

Variants for MT-TK Gene

Relevant External Links for MT-TK Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TK Gene

Disorders for MT-TK Gene

MalaCards: The human disease database

(12) MalaCards diseases for MT-TK Gene - From: ClinVar, GeneTests, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
merrf syndrome
  • fukuhara syndrome
maternally inherited diabetes and deafness
  • ballinger wallace syndrome
mt-tt related parkinson disease susceptibility
  • parkinson disease, mitochondrial
maternally-inherited cardiomyopathy and hearing loss
  • maternally-inherited cardiomyopathy and deafness
merrf/melas overlap syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MT-TK in MalaCards View complete list of genes associated with diseases

Relevant External Links for MT-TK

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MT-TK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT-TK Gene

Publications for MT-TK Gene

  1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PMID: 17619138) Ahari S.E. … Bahar M.A. (Cell. Mol. Neurobiol. 2007) 3 48 67
  2. Human tRNA(Lys3)(UUU) is pre-structured by natural modifications for cognate and wobble codon binding through keto-enol tautomerism. (PMID: 22227389) Vendeix F.A. … Agris P.F. (J. Mol. Biol. 2012) 3
  3. Familial clustering strongly suggests that the phenotypic variation of the 8344 A>G lys mitochondrial tRNA mutation is encoded in cis. (PMID: 22681518) Kazakos K. … Polychronakos C. (Ann. Hum. Genet. 2012) 3
  4. The mutations m.5628T>C and m.8348A>G in single muscle fibers of a patient with chronic progressive external ophthalmoplegia. (PMID: 22743145) Gamba J. … Tengan C.H. (J. Neurol. Sci. 2012) 3
  5. MERRF/MELAS overlap syndrome: a double pathogenic mutation in mitochondrial tRNA genes. (PMID: 20610441) Nakamura M. … Sasaki H. (J. Med. Genet. 2010) 3

Products for MT-TK Gene

Sources for MT-TK Gene