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Aliases for MT-TI Gene

Subcategory (RNA class) for MT-TI Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MT-TI Gene

  • Mitochondrially Encoded TRNA Isoleucine 2
  • TRNA Isoleucine 2
  • TRNA 3
  • TRNI 3
  • MTTI 3

External Ids for MT-TI Gene

Previous HGNC Symbols for MT-TI Gene

  • MTTI

Previous GeneCards Identifiers for MT-TI Gene

  • GC00U921603

Summaries for MT-TI Gene

GeneCards Summary for MT-TI Gene

MT-TI (Mitochondrially Encoded TRNA Isoleucine) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TI include mitochondrial non-syndromic sensorineural deafness and merrf syndrome. Among its related pathways are tRNA Aminoacylation.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TI Gene

Genomics for MT-TI Gene

Genomic Location for MT-TI Gene

Chromosome:
MT
Start:
4,263 bp from pter
End:
4,331 bp from pter
Size:
69 bases
Orientation:
Plus strand

Genomic View for MT-TI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TI Gene

No data available for Regulatory Elements for MT-TI Gene

Proteins for MT-TI Gene

Post-translational modifications for MT-TI Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TI Gene

Domains & Families for MT-TI Gene

Gene Families for MT-TI Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TI: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TI Gene

Function for MT-TI Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TI Gene

Localization for MT-TI Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-TI Gene COMPARTMENTS Subcellular localization image for MT-TI gene
Compartment Confidence
chloroplast 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MT-TI Gene

Pathways & Interactions for MT-TI Gene

SuperPathways for MT-TI Gene

Superpath Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TI: view

Pathways by source for MT-TI Gene

1 KEGG pathway for MT-TI Gene

Interacting Proteins for MT-TI Gene

Gene Ontology (GO) - Biological Process for MT-TI Gene

None

No data available for SIGNOR curated interactions for MT-TI Gene

Drugs & Compounds for MT-TI Gene

No Compound Related Data Available

Transcripts for MT-TI Gene

mRNA/cDNA for MT-TI Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TI Gene

No ASD Table

Relevant External Links for MT-TI Gene

GeneLoc Exon Structure for
MT-TI
ECgene alternative splicing isoforms for
MT-TI

Expression for MT-TI Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MT-TI Gene

Orthologs for MT-TI Gene

Evolution for MT-TI Gene

ENSEMBL:
Gene Tree for MT-TI (if available)
TreeFam:
Gene Tree for MT-TI (if available)

No data available for Orthologs for MT-TI Gene

Paralogs for MT-TI Gene

No data available for Paralogs for MT-TI Gene

Variants for MT-TI Gene

Relevant External Links for MT-TI Gene

HapMap Linkage Disequilibrium report
MT-TI
Human Gene Mutation Database (HGMD)
MT-TI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TI Gene

Disorders for MT-TI Gene

MalaCards: The human disease database

(5) MalaCards diseases for MT-TI Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial non-syndromic sensorineural deafness
  • isolated mitochondrial neurosensory deafness
merrf syndrome
  • myoclonus epilepsy and ragged red fibers
cardiomyopathy, familial hypertrophic
  • cardiomyopathy, hypertrophic, 1
chronic progressive external ophthalmoplegia
  • chronic progressive external ophthalmoplegia [ambiguous]
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association
Search MT-TI in MalaCards View complete list of genes associated with diseases

Relevant External Links for MT-TI

Genetic Association Database (GAD)
MT-TI
genes like me logo Genes that share disorders with MT-TI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT-TI Gene

Publications for MT-TI Gene

  1. Novel mitochondrial tRNA(Ile) m.4282A>G gene mutation leads to chronic progressive external ophthalmoplegia plus phenotype. (PMID: 25034047) Jackson C.B. … Schaller A. (Br J Ophthalmol 2014) 67
  2. Molecular characterization of a Chinese family carrying a novel C4329A mutation in mitochondrial tRNAIle and tRNAGln genes. (PMID: 25056089) Liu Y. … Chen Y. (BMC Med. Genet. 2014) 67
  3. [Mitochondrial DNA mutation associated with hypertension in tRNA(Ile) and tRNA(Gln) genes]. (PMID: 25297595) Zhu C. … Li Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2014) 67
  4. Juvenile parkinsonism, hypogonadism and Leigh-like MRI changes in a patient with m.4296G>A mutation in mitochondrial DNA. (PMID: 23395828) Martikainen M.H. … Majamaa K. (Mitochondrion 2013) 67
  5. The amyloid-I^-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P. (PMID: 23755257) Vilardo E. … Rossmanith W. (PLoS ONE 2013) 67

Products for MT-TI Gene

Sources for MT-TI Gene

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