Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MT-TF Gene

Subcategory (RNA class) for MT-TF Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for MT-TF Gene

  • Mitochondrially Encoded TRNA Phenylalanine 2 5
  • TRNA Phenylalanine 2
  • TRNA 3
  • TRNF 3

External Ids for MT-TF Gene

Previous HGNC Symbols for MT-TF Gene

  • MTTF

Previous GeneCards Identifiers for MT-TF Gene

  • GC00U921600

Summaries for MT-TF Gene

GeneCards Summary for MT-TF Gene

MT-TF (Mitochondrially Encoded TRNA Phenylalanine) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TF include Myoclonic Epilepsy Associated With Ragged-Red Fibers and Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes. Among its related pathways are tRNA Aminoacylation.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TF Gene

Genomics for MT-TF Gene

Genomic Location for MT-TF Gene

577 bp from pter
647 bp from pter
71 bases
Plus strand

Genomic View for MT-TF Gene

Genes around MT-TF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TF Gene

No data available for Regulatory Elements for MT-TF Gene

Proteins for MT-TF Gene

Post-translational modifications for MT-TF Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TF Gene

Domains & Families for MT-TF Gene

Gene Families for MT-TF Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TF: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TF Gene

Function for MT-TF Gene

Human Phenotype Ontology for MT-TF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TF Gene

Localization for MT-TF Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT-TF gene
Compartment Confidence
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MT-TF Gene

Pathways & Interactions for MT-TF Gene

SuperPathways for MT-TF Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TF: view

Pathways by source for MT-TF Gene

1 KEGG pathway for MT-TF Gene

Interacting Proteins for MT-TF Gene

Gene Ontology (GO) - Biological Process for MT-TF Gene


No data available for SIGNOR curated interactions for MT-TF Gene

Drugs & Compounds for MT-TF Gene

No Compound Related Data Available

Transcripts for MT-TF Gene

mRNA/cDNA for MT-TF Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TF Gene

No ASD Table

Relevant External Links for MT-TF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-TF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT-TF Gene

Phenotype-based relationships between genes and organs from Gene ORGANizer for MT-TF Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • urinary
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • kidney
  • pancreas
  • stomach
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with MT-TF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MT-TF Gene

Orthologs for MT-TF Gene

Evolution for MT-TF Gene

Gene Tree for MT-TF (if available)
Gene Tree for MT-TF (if available)

No data available for Orthologs for MT-TF Gene

Paralogs for MT-TF Gene

No data available for Paralogs for MT-TF Gene

Variants for MT-TF Gene

Relevant External Links for MT-TF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TF Gene

Disorders for MT-TF Gene

MalaCards: The human disease database

(5) MalaCards diseases for MT-TF Gene - From: ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myoclonic epilepsy associated with ragged-red fibers
  • merrf syndrome
mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes
  • melas syndrome
melas, mt-tf-related
  • melas, mttf-related
mitochondrial disorders
  • mitochondrial encephalomyopathies
megaloblastic anemia
  • megaloblastic anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search MT-TF in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MT-TF: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for MT-TF Gene

Publications for MT-TF Gene

  1. Optic neuropathy, cardiomyopathy, cognitive disability in patients with a homozygous mutation in the nuclear MTO1 and a mitochondrial MT-TF variant. (PMID: 26061759) Charif M. … Hamel C.P. (Am. J. Med. Genet. A 2015) 3 64
  2. Severe epilepsy as the major symptom of new mutations in the mitochondrial tRNA(Phe) gene. (PMID: 20142618) Zsurka G. … Kunz W.S. (Neurology 2010) 3 64
  3. MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease. (PMID: 19758471) Bhardwaj A. … Tiwari S. (BMC Bioinformatics 2009) 3 64
  4. A novel mutation in the mitochondrial tRNA(Phe) gene associated with mitochondrial myopathy. (PMID: 14659412) Moslemi A.R. … Oldfors A. (Neuromuscul. Disord. 2004) 3 64
  5. Mitochondrial Disorders Overview (PMID: 20301403) Pagon R.A. … Stephens K. ( 1993) 3 64

Products for MT-TF Gene

Sources for MT-TF Gene

Loading form....