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Aliases for MT-RNR2 Gene

Subcategory (RNA class) for MT-RNR2 Gene

Mt_rRNA

Quality Score for this RNA gene is

3

Aliases for MT-RNR2 Gene

  • Mitochondrially Encoded 16S RNA 2
  • Humanin Mitochondrial 4
  • Formyl-Humanin 2
  • Humanin 2
  • L-RRNA 3
  • MTRNR2 3
  • RNR2 3
  • HNM 4
  • HN 4

External Ids for MT-RNR2 Gene

Previous HGNC Symbols for MT-RNR2 Gene

  • MTRNR2

Previous GeneCards Identifiers for MT-RNR2 Gene

  • GC00U921595

Summaries for MT-RNR2 Gene

GeneCards Summary for MT-RNR2 Gene

MT-RNR2 (Mitochondrially Encoded 16S RNA) is an RNA Gene, and is affiliated with the Mt_rRNA class. Diseases associated with MT-RNR2 include chronic progressive external ophthalmoplegia and alzheimer disease. Among its related pathways are Ribosome biogenesis in eukaryotes and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins.

UniProtKB/Swiss-Prot for MT-RNR2 Gene

  • Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-RNR2 Gene

Genomics for MT-RNR2 Gene

Genomic Location for MT-RNR2 Gene

Start:
1,671 bp from pter
End:
3,229 bp from pter
Size:
1,559 bases
Orientation:
Plus strand

Genomic View for MT-RNR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for MT-RNR2 Gene

No data available for Regulatory Elements for MT-RNR2 Gene

Proteins for MT-RNR2 Gene

  • Protein details for MT-RNR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVG9-HUNIN_HUMAN
    Recommended name:
    Humanin
    Protein Accession:
    Q8IVG9
    Secondary Accessions:

    Protein attributes for MT-RNR2 Gene

    Size:
    24 amino acids
    Molecular mass:
    2687 Da
    Quaternary structure:
    • Interacts with BAX, IGFBP3 and TRIM11.

    Three dimensional structures from OCA and Proteopedia for MT-RNR2 Gene

neXtProt entry for MT-RNR2 Gene

Proteomics data for MT-RNR2 Gene at MOPED

Post-translational modifications for MT-RNR2 Gene

No Post-translational modifications

Other Protein References for MT-RNR2 Gene

Reactome Protein details:

No data available for DME Specific Peptides for MT-RNR2 Gene

Domains for MT-RNR2 Gene

Gene Families for MT-RNR2 Gene

Protein Domains for MT-RNR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MT-RNR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVG9

UniProtKB/Swiss-Prot:

HUNIN_HUMAN :
  • Largely unstructured in aqueous solution.
  • Belongs to the humanin family.
Domain:
  • Largely unstructured in aqueous solution.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MT-RNR2: view

Function for MT-RNR2 Gene

Molecular function for MT-RNR2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.
UniProtKB/Swiss-Prot Induction:
Release is regulated by intracellular mechanism. The intracellular level is regulated by TRIM11 through proteasome-mediated degradation.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-RNR2 Gene

Localization for MT-RNR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-RNR2 Gene

Secreted. Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MT-RNR2 Gene

Drugs for MT-RNR2 Gene

(5) Drugbank Compounds for MT-RNR2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
440552 Target experimental
2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid
13728878 Target, Target experimental
Beta-Sialic Acid
36690637 Target experimental
Methyl(6s)-1-Thio-L-Manno-Hexodialdo-6,2-Pyranoside
46936993 Target experimental
O-Sialic Acid
36690637 Target experimental

(1) ApexBio Compounds for MT-RNR2 Gene

Compound Action Cas Number
Amikacin disulfate [39831-55-5]
genes like me logo Genes that share compounds with MT-RNR2: view

Transcripts for MT-RNR2 Gene

mRNA/cDNA for MT-RNR2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-RNR2 Gene

No ASD Table

Relevant External Links for MT-RNR2 Gene

GeneLoc Exon Structure for
MT-RNR2
ECgene alternative splicing isoforms for
MT-RNR2

Expression for MT-RNR2 Gene

mRNA expression in normal human tissues for MT-RNR2 Gene

mRNA differential expression in normal tissues according to GTEx for MT-RNR2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.3).

mRNA Expression by UniProt/SwissProt for MT-RNR2 Gene

Q8IVG9-HUNIN_HUMAN
Tissue specificity: Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.
genes like me logo Genes that share expressions with MT-RNR2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for MT-RNR2 Gene

Orthologs for MT-RNR2 Gene

Evolution for MT-RNR2 Gene

ENSEMBL:
Gene Tree for MT-RNR2 (if available)
TreeFam:
Gene Tree for MT-RNR2 (if available)

No data available for Orthologs for MT-RNR2 Gene

Paralogs for MT-RNR2 Gene

(5) SIMAP similar genes for MT-RNR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-RNR2: view

No data available for Paralogs for MT-RNR2 Gene

Variants for MT-RNR2 Gene

Relevant External Links for MT-RNR2 Gene

HapMap Linkage Disequilibrium report
MT-RNR2
Human Gene Mutation Database (HGMD)
MT-RNR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MT-RNR2 Gene

Disorders for MT-RNR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MT-RNR2 Gene in MalaCards »

(2) Diseases for MT-RNR2 Gene

Relevant External Links for MT-RNR2

Genetic Association Database (GAD)
MT-RNR2
genes like me logo Genes that share disorders with MT-RNR2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MT-RNR2 Gene

Publications for MT-RNR2 Gene

  1. Mitochondrial polymorphisms as risk factors for endometrial cancer in southwest China. (PMID: 16884381) Xu L. … Xiao C. (Int. J. Gynecol. Cancer 2006) 3 48
  2. [Study on the mitochondrial DNA variation in patients with type 2 diabetes mellitus]. (PMID: 17407074) Ji J.Z. … Wang D.W. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 48
  3. Solution structure of humanin, a peptide against Alzheimer's disease- related neurotoxicity. (PMID: 15721287) Benaki D. … Pelecanou M. (Biochem. Biophys. Res. Commun. 2005) 3 4
  4. Genotyping Parkinson disease-associated mitochondrial polymorphisms. (PMID: 15931342) Jiang Y. … Greenlee A.R. (Clin Med Res 2004) 3 48
  5. The G1888A variant in the mitochondrial 16S rRNA gene may be associated with Type 2 diabetes in Caucasian-Brazilian patients from southern Brazil. (PMID: 16401312) Crispim D. … Roisenberg I. (Diabet. Med. 2005) 3 48

Products for MT-RNR2 Gene

Sources for MT-RNR2 Gene

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