Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MT-RNR2 Gene

Subcategory (RNA class) for MT-RNR2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MT-RNR2 Gene

  • Mitochondrially Encoded 16S RNA 2 5
  • Humanin Mitochondrial 4
  • Formyl-Humanin 2
  • Humanin 2
  • L-RRNA 3
  • MTRNR2 3
  • RNR2 3
  • HNM 4
  • HN 4

External Ids for MT-RNR2 Gene

Previous HGNC Symbols for MT-RNR2 Gene

  • MTRNR2

Previous GeneCards Identifiers for MT-RNR2 Gene

  • GC00U921595

Summaries for MT-RNR2 Gene

GeneCards Summary for MT-RNR2 Gene

MT-RNR2 (Mitochondrially Encoded 16S RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-RNR2 include mitochondrial disorders and tubulointerstitial nephritis and uveitis. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for MT-RNR2 Gene

  • Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-RNR2 Gene

Genomics for MT-RNR2 Gene

Genomic Location for MT-RNR2 Gene

Chromosome:
MT
Start:
1,671 bp from pter
End:
3,229 bp from pter
Size:
1,559 bases
Orientation:
Plus strand

Genomic View for MT-RNR2 Gene

Genes around MT-RNR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-RNR2 Gene

No data available for Regulatory Elements for MT-RNR2 Gene

Proteins for MT-RNR2 Gene

  • Protein details for MT-RNR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVG9-HUNIN_HUMAN
    Recommended name:
    Humanin
    Protein Accession:
    Q8IVG9

    Protein attributes for MT-RNR2 Gene

    Size:
    24 amino acids
    Molecular mass:
    2687 Da
    Quaternary structure:
    • Interacts with BAX, IGFBP3 and TRIM11.

    Three dimensional structures from OCA and Proteopedia for MT-RNR2 Gene

neXtProt entry for MT-RNR2 Gene

Proteomics data for MT-RNR2 Gene at MOPED

Post-translational modifications for MT-RNR2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-RNR2 Gene

Domains & Families for MT-RNR2 Gene

Gene Families for MT-RNR2 Gene

Protein Domains for MT-RNR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MT-RNR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVG9

UniProtKB/Swiss-Prot:

HUNIN_HUMAN :
  • Largely unstructured in aqueous solution.
  • Belongs to the humanin family.
Domain:
  • Largely unstructured in aqueous solution.
Family:
  • Belongs to the humanin family.
genes like me logo Genes that share domains with MT-RNR2: view

Function for MT-RNR2 Gene

Molecular function for MT-RNR2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.
UniProtKB/Swiss-Prot Induction:
Release is regulated by intracellular mechanism. The intracellular level is regulated by TRIM11 through proteasome-mediated degradation.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-RNR2 Gene

Localization for MT-RNR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-RNR2 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-RNR2 Gene COMPARTMENTS Subcellular localization image for MT-RNR2 gene
Compartment Confidence
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MT-RNR2 Gene

Pathways & Interactions for MT-RNR2 Gene

genes like me logo Genes that share pathways with MT-RNR2: view

Pathways by source for MT-RNR2 Gene

Gene Ontology (GO) - Biological Process for MT-RNR2 Gene

None

No data available for SIGNOR curated interactions for MT-RNR2 Gene

Drugs & Compounds for MT-RNR2 Gene

(6) Drugs for MT-RNR2 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Experimental Pharma Target 0
2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid Experimental Pharma Target, Target 0
Beta-Sialic Acid Experimental Pharma Target 0
Methyl(6s)-1-Thio-L-Manno-Hexodialdo-6,2-Pyranoside Experimental Pharma Target 0
O-Sialic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with MT-RNR2: view

Transcripts for MT-RNR2 Gene

mRNA/cDNA for MT-RNR2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-RNR2 Gene

No ASD Table

Relevant External Links for MT-RNR2 Gene

GeneLoc Exon Structure for
MT-RNR2
ECgene alternative splicing isoforms for
MT-RNR2

Expression for MT-RNR2 Gene

mRNA expression in normal human tissues for MT-RNR2 Gene

mRNA differential expression in normal tissues according to GTEx for MT-RNR2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.3).

mRNA Expression by UniProt/SwissProt for MT-RNR2 Gene

Q8IVG9-HUNIN_HUMAN
Tissue specificity: Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.
genes like me logo Genes that share expression patterns with MT-RNR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MT-RNR2 Gene

Orthologs for MT-RNR2 Gene

Evolution for MT-RNR2 Gene

ENSEMBL:
Gene Tree for MT-RNR2 (if available)
TreeFam:
Gene Tree for MT-RNR2 (if available)

No data available for Orthologs for MT-RNR2 Gene

Paralogs for MT-RNR2 Gene

(5) SIMAP similar genes for MT-RNR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-RNR2: view

No data available for Paralogs for MT-RNR2 Gene

Variants for MT-RNR2 Gene

Relevant External Links for MT-RNR2 Gene

HapMap Linkage Disequilibrium report
MT-RNR2
Human Gene Mutation Database (HGMD)
MT-RNR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-RNR2 Gene

Disorders for MT-RNR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MT-RNR2 Gene - From: GeneTests

Disorder Aliases PubMed IDs
mitochondrial disorders
  • mitochondrial encephalomyopathies
tubulointerstitial nephritis and uveitis
  • tinu
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MT-RNR2

Genetic Association Database (GAD)
MT-RNR2
genes like me logo Genes that share disorders with MT-RNR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT-RNR2 Gene

Publications for MT-RNR2 Gene

  1. [Study on the mitochondrial DNA variation in patients with type 2 diabetes mellitus]. (PMID: 17407074) Ji J.Z. … Wang D.W. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 48 67
  2. High-frequency involved hearing loss caused by novel mitochondrial DNA mutation in 16S ribosomal RNA gene. (PMID: 24770403) Abe S. … Usami S. (Otol. Neurotol. 2014) 3
  3. The novel mitochondrial 16S rRNA 2336T>C mutation is associated with hypertrophic cardiomyopathy. (PMID: 24367055) Liu Z. … Yan Q. (J. Med. Genet. 2013) 3
  4. Genotyping mitochondrial DNA single nucleotide polymorphisms by PCR ligase detection reactions. (PMID: 20128730) Luo Y. … Gao Y. (Clin. Chem. Lab. Med. 2010) 3
  5. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. (PMID: 19920115) Alsbeih G.A. … Abu-Amero K.K. (Clin. Cancer Res. 2009) 3

Products for MT-RNR2 Gene

Sources for MT-RNR2 Gene

Back to Top

Content