Subcategory (RNA class) for MT-RNR1 Gene
Quality Score for this RNA gene is
Aliases for MT-RNR1 Gene
External Ids for MT-RNR1 Gene
Previous HGNC Symbols for MT-RNR1 Gene
Previous GeneCards Identifiers for MT-RNR1 Gene
GeneCards Summary for MT-RNR1 Gene
MT-RNR1 (Mitochondrially Encoded 12S RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-RNR1 include deafness, mitochondrial, modifier of and mitochondrial non-syndromic sensorineural deafness with susceptibility to aminoglycoside exposure. Among its related pathways are Viral mRNA Translation and Ribosome biogenesis in eukaryotes.
UniProtKB/Swiss-Prot for MT-RNR1 Gene
Regulates insulin sensitivity and metabolic homeostasis. Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5-AMP-activated protein kinase (AMPK). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity.