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MT-ND6 Gene

protein-coding   GIFtS: 45
GCID: GCMTM014151

Mitochondrially Encoded NADH Dehydrogenase 6

(Previous name: NADH dehydrogenase 6)
(Previous symbol: MTND6)
  See MT-ND6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrially Encoded NADH Dehydrogenase 61     Complex I ND6 Subunit1
MTND61 2 3     NADH Dehydrogenase 61
ND62 3     NADH-Ubiquinone Oxidoreductase Chain 61
NADH Dehydrogenase Subunit 62 3     NADH Dehydrogenase, Subunit 6 (Complex I)2
EC 1.6.5.33 8     NADH63

External Ids:    HGNC: 74621   Entrez Gene: 45412   Ensembl: ENSG000001986957   OMIM: 5160065   UniProtKB: P039233   

Export aliases for MT-ND6 gene to outside databases

Previous GC identifer: GC00U921593


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-ND6 Gene:
MT-ND6 (mitochondrially encoded NADH dehydrogenase 6) is a protein-coding gene. Diseases associated with MT-ND6 include leber hereditary optic neuropathy with dystonia, and melas, mt-nd6-related.

UniProtKB/Swiss-Prot: NU6M_HUMAN, P03923
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)

Gene Wiki entry for MT-ND6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-ND6
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-ND6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-ND6


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTM014151:       (about GC identifiers)

Start:
14,149 bp from pter      End:
14,673 bp from pter
Size:
525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NU6M_HUMAN, P03923 (See protein sequence)
Recommended Name: NADH-ubiquinone oxidoreductase chain 6  
Size: 174 amino acids; 18622 Da
Secondary accessions: Q34774 Q8HG30

Explore the universe of human proteins at neXtProt for MT-ND6: NX_P03923

Explore proteomics data for MT-ND6 at MOPED

Selected DME Specific Peptides for MT-ND6 (P03923) (see all 7)
 FLIYLGGM  GFSSKPSP  YLGGMMVVF  MEVGLVLWV 


See MT-ND6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000354665  
Reactome Protein details: P03923

MT-ND6 Human Recombinant Protein Products:

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antibodies-online antibodies for MT-ND6 (15 products) 

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antibodies-online kits for MT-ND6 (18 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
comI: Mitochondrial respiratory chain complex / Complex I

1 InterPro protein domain:
 IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6

Graphical View of Domain Structure for InterPro Entry P03923

ProtoNet protein and cluster: P03923

1 Blocks protein domain: IPB001457 NADH-ubiquinone/plastoquinone oxidoreductase

UniProtKB/Swiss-Prot: NU6M_HUMAN, P03923
Similarity: Belongs to the complex I subunit 6 family


Find genes that share domains with MT-ND6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NU6M_HUMAN, P03923
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)
Catalytic activity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)

     Enzyme Number (IUBMB): EC 1.6.5.31 2

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008137NADH dehydrogenase (ubiquinone) activity ----
     
Find genes that share ontologies with MT-ND6           About GenesLikeMe


Phenotypes:
     6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for mt-Nd6):
 cardiovascular system  cellular  homeostasis/metabolism  nervous system  tumorigenesis 
 vision/eye 

Find genes that share phenotypes with MT-ND6           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT-ND6
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT-ND6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT-ND6
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT-ND6

miRNA
Products:
    
miRTarBase miRNAs that target MT-ND6:
hsa-mir-197-3p (MIRT048059), hsa-mir-125a-5p (MIRT045743), hsa-mir-125b-5p (MIRT046027), hsa-mir-484 (MIRT041704), hsa-mir-130b-5p (MIRT038330), hsa-mir-99b-5p (MIRT044193), hsa-mir-149-5p (MIRT045537), hsa-mir-877-3p (MIRT036990), hsa-mir-328-3p (MIRT043775), hsa-mir-10b-5p (MIRT047440), hsa-mir-30c-5p (MIRT047901)

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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat MT-ND6

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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NU6M_HUMAN, P03923: Mitochondrion membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
plasma membrane3
lysosome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane ----
GO:0005747mitochondrial respiratory chain complex I ----
GO:0016021integral component of membrane ----

Find genes that share ontologies with MT-ND6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MT-ND6 About    
See pathways by source

SuperPathContained pathways About
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
Oxidative phosphorylation0.64
Respiratory electron transport0.81
Parkinson's disease0.57
Electron Transport Chain0.75
Oxidative phosphorylation0.51
The citric acid (TCA) cycle and respiratory electron transport0.71
2Metabolism
Metabolism0.38
Metabolic pathways0.38


Find genes that share SuperPaths with MT-ND6           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for MT-ND6
    Oxidative phosphorylation
Electron Transport Chain

1 Reactome Pathway for MT-ND6
    Respiratory electron transport


3 Kegg Pathways  (Kegg details for MT-ND6):
    Oxidative phosphorylation
Metabolic pathways
Parkinson's disease

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-ND6
Interactions:

    Search GeneGlobe Interaction Network for MT-ND6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MT-ND6 (P039233 ENSP000003546654) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
InteractantInteraction Details
GeneCardExternal ID(s)
NDUFS3O754893, ENSP000002637744I2D: score=2 STRING: ENSP00000263774
MAP2K2P365073I2D: score=2 
NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
MT-CYBENSP000003545544STRING: ENSP00000354554
MT-ND1ENSP000003546874STRING: ENSP00000354687
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006120mitochondrial electron transport, NADH to ubiquinone ----
GO:0022904respiratory electron transport chain ----
GO:0044237cellular metabolic process ----
GO:0044281small molecule metabolic process ----
GO:0055114oxidation-reduction process ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MT-ND6 (NU6M)

9 HMDB Compounds for MT-ND6    About this table
CompoundSynonyms CAS #PubMed Ids
FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
IronArmco iron (see all 19)7439-89-6--
NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
QH2CoQH2 (see all 5)56275-39-9--
SulfideSulfide (see all 4)18496-25-8--
Ubiquinol 8ubiquinol-8 (see all 2)56275-39-9--
Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

1 DrugBank Compound for MT-ND6    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

9 Novoseek inferred chemical compound relationships for MT-ND6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nadh 76.4 33 12942631 (2), 2176148 (1), 8016139 (1), 8082208 (1) (see all 20)
isoleucine 46.5 1 8644732 (1)
valine 45.4 4 8016139 (1), 8622678 (1), 14735585 (1)
rotenone 37.7 1 15248896 (1)
methionine 27.1 1 8644732 (1)
alanine 22.1 4 8016139 (1), 8622678 (1), 14735585 (1)
oxygen 0 2 19801684 (1), 16337195 (1)
tyrosine 0 1 14517421 (1)
serine 0 1 10447650 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000361681
miRNA
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Primer
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MT-ND6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MT-ND6 Expression
About this image

MT-ND6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MT-ND6 Protein Expression
    Custom PCR Arrays for MT-ND6
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MT-ND6 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia mt-Nd65
ND61
mitochondrially encoded NADH dehydrogenase 65
ND61
63.47(n)1
52.1(a)1
  MT5
177221  ND6_345386091  NP_904339.11 
 135525 
chicken
(Gallus gallus)
Aves MT-ND66
NADH-ubiquinone oxidoreductase chain 6
32(a)
1 ↔ 1
MT(16184-16705) ENSGALG00000018357
lizard
(Anolis carolinensis)
Reptilia ND66
--
Uncharacterized protein
32(a)
32(a)
many → 1
many → 1
MT(13471-13995)
AAWZ02037236(2089-2610)
zebrafish
(Danio rerio)
Actinopterygii mt-nd66
NADH dehydrogenase 6, mitochondrial
33(a)
1 ↔ 1
MT(14714-15232) ENSDARG00000063922


ENSEMBL Gene Tree for MT-ND6 (if available)
TreeFam Gene Tree for MT-ND6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MT-ND6 gene
2 SIMAP similar genes for MT-ND6 using alignment to 1 protein entry:     NU6M_HUMAN:
NADH6    ND6

Find genes that share paralogs with MT-ND6           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for MT-ND6 (see all 35)
PGOHUM00000242380 PGOHUM00000239391 PGOHUM00000248449 PGOHUM00000248466 PGOHUM00000247878


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MT-ND6 (see all 14)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr MT posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0047644
Mitochondrial complex I deficiency (MT-C1D)4--see VAR_0047642 A V mis40--------
VAR_0085124
Leber hereditary optic neuropathy (LHON)4--see VAR_0085122 M I mis40--------
VAR_0083944
Leber hereditary optic neuropathy with dystonia (LDYT)4--see VAR_0083942 I M mis40--------
VAR_0047634
Leber hereditary optic neuropathy (LHON)4--see VAR_0047632 M V mis40--------
VAR_0083954
Leber hereditary optic neuropathy (LHON)4--see VAR_0083952 G S mis40--------
VAR_0143964
Leber hereditary optic neuropathy (LHON)4--see VAR_0143962 L S mis40--------
VAR_0143974
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)4--see VAR_0143972 A V mis40--------
VAR_0645684
Mitochondrial complex I deficiency (MT-C1D)4--see VAR_0645682 M V mis40--------
VAR_0083964
Leber hereditary optic neuropathy (LHON)4--see VAR_0083962 Y C mis40--------
VAR_0143944
----see VAR_0143942 I V mis40--------

HapMap Linkage Disequilibrium report for MT-ND6 (14149 - 14673 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MT-ND6: --
Human Gene Mutation Database (HGMD): MT-ND6
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-ND6
DNA2.0 Custom Variant and Variant Library Synthesis for MT-ND6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 516006    OMIM disorders: --

UniProtKB/Swiss-Prot: NU6M_HUMAN, P03923
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Leber hereditary optic neuropathy with dystonia (LDYT) [MIM:500001]: Part of a spectrum of Leber
    hereditary optic neuropathy. It is characterized by the association of optic atrophy and central vision loss with
    dystonia. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)
    [MIM:540000]: Genetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent
    cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory
    chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset
    neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific
    encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and
    some forms of Parkinson disease. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 15 diseases for MT-ND6:    
    About MalaCards
    leber hereditary optic neuropathy with dystonia    melas, mt-nd6-related    leber hereditary optic neuropathy    porphyria cutanea tarda, type ii
    multicentric carpotarsal osteolysis syndrome    hereditary neuropathies    kearns-sayre syndrome    mitochondrial encephalomyopathy
    encephalomyopathy    melas syndrome    neuritis    mitochondrial dna-associated leigh syndrome and narp
    leigh disease    mitochondrial disorders    mitochondrial complex i deficiency

    2 diseases from the University of Copenhagen DISEASES database for MT-ND6:
    Leber hereditary optic neuropathy     MELAS syndrome

    Find genes that share disorders with MT-ND6           About GenesLikeMe

    3 Novoseek inferred disease relationships for MT-ND6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers hereditary optic neuropathy 90.7 9 9177303 (3), 7488023 (1), 8622678 (1), 17894548 (1) (see all 7)
    leigh syndrome 73.1 3 14595656 (2), 19349200 (1)
    optic neuropathy 42.6 1 11133798 (1)

    GeneTests: MT-ND6
    GeneReviews: MT-ND6
    Genetic Association Database (GAD): MT-ND6

    Export disorders for MT-ND6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT-ND6 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with MT-ND6)
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    1. Mitochondrial D-loop variation in leber hereditary neuropathy patients harboring primary G11778A, G3460A, T14484C mutations: J and W haplogroups as high-risk factors. (PubMed id 17045122)1, 4 Shafa Shariat Panahi M....Tabassi A.R. (Arch. Med. Res. 2006)
    2. Mitochondrial DNA mutations with Leber's hereditary optic neuropathy in Japanese patients with open-angle glaucoma. (PubMed id 16604388)1, 4 Inagaki Y....Fukuchi T. (Jpn. J. Ophthalmol. 2006)
    3. [Clinical features and the mutation of Leber's hereditary optic neuropathy in Chinese patients]. (PubMed id 15952130)1, 4 Wang Y....Zhang Q.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    4. Association of the mitochondrial DNA haplogroup J with longevity is population specific. (PubMed id 15470367)1, 4 Dato S....De Benedictis G. (Eur. J. Hum. Genet. 2004)
    5. Lack of association between Leber's hereditary optic neuropathy primary point mutations and multiple sclerosis in Iran. (PubMed id 14671420)1, 4 Houshmand M....Lotfi J. (Eur. Neurol. 2004)
    6. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (Nature 1981)
    7. Leber's hereditary optic neuropathy: clinical and molecular genetic findings in a patient with a new mutation in the ND6 gene. (PubMed id 10447650)2, 9 Besch D.... Wissinger B. (Graefes Arch. Clin. Exp. Ophthalmol. 1999)
    8. Free radicals-mediated damage in transmitochondrial cells harboring the T14487C mutation in the ND6 gene of mtDNA. (PubMed id 16337195)1, 9 Gonzalo R....Andreu A.L. (FEBS Lett. 2005)
    9. Impaired complex I assembly in a Leigh syndrome patient with a novel missense mutation in the ND6 gene. (PubMed id 14595656)2, 9 Ugalde C....Nijtmans L.G. (Ann. Neurol. 2003)
    10. The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy. (PubMed id 11133798)2, 9 Chinnery P.F.... Howell N. (Brain 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4541 HGNC: 7462 Ensembl:ENSG00000198695 euGenes: HUgn4541 ECgene: MT-ND6 Kegg: 4541
    H-InvDB: MT-ND6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT-ND6 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MT-ND6[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for MT-ND6 gene:
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