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MT-ND5 Gene

protein-coding   GIFtS: 45
GCID: GCMTP012339

Mitochondrially Encoded NADH Dehydrogenase 5

(Previous name: NADH dehydrogenase 5)
(Previous symbol: MTND5)
  See MT-ND5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrially Encoded NADH Dehydrogenase 51     Complex I ND5 Subunit1
MTND51 2 3     NADH Dehydrogenase 51
ND52 3     NADH-Ubiquinone Oxidoreductase Chain 51
NADH Dehydrogenase Subunit 52 3     NADH Dehydrogenase, Subunit 5 (Complex I)2
EC 1.6.5.33 8     NADH53

External Ids:    HGNC: 74611   Entrez Gene: 45402   Ensembl: ENSG000001987867   OMIM: 5160055   UniProtKB: P039153   

Export aliases for MT-ND5 gene to outside databases

Previous GC identifer: GC00U921592


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-ND5 Gene:
MT-ND5 (mitochondrially encoded NADH dehydrogenase 5) is a protein-coding gene. Diseases associated with MT-ND5 include melas, mt-nd5-related, and merrf syndrome.

UniProtKB/Swiss-Prot: NU5M_HUMAN, P03915
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-ND5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-ND5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-ND5


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP012339:       (about GC identifiers)

Start:
12,337 bp from pter      End:
14,148 bp from pter
Size:
1,812 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NU5M_HUMAN, P03915 (See protein sequence)
Recommended Name: NADH-ubiquinone oxidoreductase chain 5  
Size: 603 amino acids; 67027 Da
Secondary accessions: Q34773 Q8WCY3

Explore the universe of human proteins at neXtProt for MT-ND5: NX_P03915

Explore proteomics data for MT-ND5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MT-ND5 (P03915) (see all 34)
     LYNRIGD  LAFLHIC  GQPRFPT  EFSLWYM 


    See MT-ND5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000354813  
    Reactome Protein details: P03915

    MT-ND5 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for MT-ND5 (3 products) 

     
    antibodies-online peptides for MT-ND5

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    antibodies-online antibodies for MT-ND5 (44 products) 

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    antibodies-online kits for MT-ND5 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    4 InterPro protein domains:
     IPR001516 NADH_UbQ_OxRdtase_chain5/L_N
     IPR003945 NADHpl_OxRdtase_5
     IPR010934 NADH_DH_su5_C
     IPR001750 NADH_UbQ/plastoQ_OxRdtase

    Graphical View of Domain Structure for InterPro Entry P03915

    ProtoNet protein and cluster: P03915

    1 Blocks protein domain: IPB003916 NADH-ubiquinone oxidoreductase chain 5 signature

    UniProtKB/Swiss-Prot: NU5M_HUMAN, P03915
    Similarity: Belongs to the complex I subunit 5 family


    Find genes that share domains with MT-ND5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NU5M_HUMAN, P03915
    Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
    believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
    electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
    ubiquinone (By similarity)
    Catalytic activity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)

         Enzyme Number (IUBMB): EC 1.6.5.31 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity ----
         
    Find genes that share ontologies with MT-ND5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MT-ND5

    miRNA
    Products:
        
    miRTarBase miRNAs that target MT-ND5:
    hsa-mir-320a (MIRT044636), hsa-mir-423-5p (MIRT038034), hsa-mir-186-5p (MIRT045017), hsa-let-7c-5p (MIRT051769), hsa-mir-1180-3p (MIRT035951), hsa-let-7e-5p (MIRT051464), hsa-mir-296-3p (MIRT038463), hsa-let-7b-5p (MIRT052013), hsa-mir-196a-5p (MIRT048240), hsa-mir-196b-5p (MIRT042684), hsa-let-7f-5p (MIRT051359), hsa-let-7a-5p (MIRT052454)

    Block miRNA regulation of human, mouse, rat MT-ND5 using miScript Target Protectors
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NU5M_HUMAN, P03915: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane3
    nucleus2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane ----
    GO:0005747mitochondrial respiratory chain complex I ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with MT-ND5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT-ND5 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Oxidative phosphorylation0.51
    The citric acid (TCA) cycle and respiratory electron transport0.71
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38


    Find genes that share SuperPaths with MT-ND5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MT-ND5
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for MT-ND5
        Respiratory electron transport


    3 Kegg Pathways  (Kegg details for MT-ND5):
        Oxidative phosphorylation
    Metabolic pathways
    Parkinson's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-ND5
    Interactions:

        Search GeneGlobe Interaction Network for MT-ND5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MT-ND5 (P039153 ENSP000003548134) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLULP151043, ENSP000003079004I2D: score=3 STRING: ENSP00000307900
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    PACSIN1Q9BY113I2D: score=2 
    SREBF2Q127723I2D: score=2 
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone ----
    GO:0022904respiratory electron transport chain ----
    GO:0042773ATP synthesis coupled electron transport ----
    GO:0044237cellular metabolic process ----
    GO:0044281small molecule metabolic process ----

    Find genes that share ontologies with MT-ND5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT-ND5 (NU5M)

    4 HMDB Compounds for MT-ND5    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Ubiquinol 8ubiquinol-8 (see all 2)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--

    1 DrugBank Compound for MT-ND5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17614984 17139284 17016423 9071018

    10 Novoseek inferred chemical compound relationships for MT-ND5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 78 31 2176148 (1), 12116593 (1), 15291971 (1), 18587274 (1) (see all 24)
    valine 27.1 1 1732158 (1)
    phosphoenolpyruvate 26.1 2 12116593 (1), 16611603 (1)
    atp 21.5 4 15291971 (1), 19026397 (1), 12964965 (1)
    methionine 13.9 2 15278763 (1), 1732158 (1)
    oligonucleotide 13.6 1 8809113 (1)
    threonine 12.4 3 10449650 (1), 15278763 (1), 1732158 (1)
    leucine 0.217 1 10480366 (1)
    alanine 0 1 1732158 (1)
    serine 0 3 10449650 (1), 10480366 (1), 1732158 (1)



    Find genes that share compounds with MT-ND5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361567(uc004cox.4)
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MT-ND5
      QuantiFast Probe-based Assays in human, mouse, rat MT-ND5

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT-ND5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT-ND5 Expression
    About this image

    MT-ND5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT-ND5 Protein Expression
        Custom PCR Arrays for MT-ND5
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MT-ND5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia mt-Nd55
    ND51
    mitochondrially encoded NADH dehydrogenase 55
    ND51
    66.67(n)1
    65.45(a)1
      MT5
    177211  ND5_345386081  NP_904338.11 
     117425 
    chicken
    (Gallus gallus)
    Aves ND51 ND5 64.38(n)
    58.27(a)
      807642  ND5_5834854  NP_006925.1 
    lizard
    (Anolis carolinensis)
    Reptilia ND56
    NADH dehydrogenase subunit 5 (mitochondrion)
    56(a)
    1 ↔ 1
    MT(11670-13475)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ND51 ND5 63.93(n)
    59.69(a)
      3283502  ND5_58618675  YP_203380.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ND51 ND5 62.73(n)
    60.19(a)
      140535  ND5_8395622  NP_059341.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ND51 ND5 46.76(n)
    37.83(a)
      192478  ND5_5835241  NP_008284.1 
    worm
    (Caenorhabditis elegans)
    Secernentea MTCE.356
    NADH-ubiquinone oxidoreductase chain 5
    28(a)
    1 ↔ 1
    MtDNA(11691-13272) WBGene00010967


    ENSEMBL Gene Tree for MT-ND5 (if available)
    TreeFam Gene Tree for MT-ND5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT-ND5 gene
    3 SIMAP similar genes for MT-ND5 using alignment to 1 protein entry:     NU5M_HUMAN:
    NADH5    ndh5    ND5

    Find genes that share paralogs with MT-ND5           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for MT-ND5 (see all 56)
    PGOHUM00000238406 PGOHUM00000238664 PGOHUM00000238884 PGOHUM00000242594 PGOHUM00000242662


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MT-ND5 (see all 26)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr MT posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354304
    Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)4--see VAR_0354302 D N mis40--------
    rs283591781,2,4
    Leber hereditary optic neuropathy (LHON)4--see VAR_0047612 mis40--------
    VAR_0354264
    Leber hereditary optic neuropathy (LHON)4--see VAR_0354262 A V mis40--------
    VAR_0047624
    Leber hereditary optic neuropathy (LHON)4--see VAR_0047622 G E mis40--------
    VAR_0645664
    Mitochondrial complex I deficiency (MT-C1D)4--see VAR_0645662 V A mis40--------
    VAR_0354244
    Mitochondrial complex I deficiency (MT-C1D)4--see VAR_0354242 F L mis40--------
    VAR_0354254
    Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)4--see VAR_0354252 E G mis40--------
    VAR_0088724
    ----see VAR_0088722 D G mis40--------
    VAR_0354294
    ----see VAR_0354292 S C mis40--------
    VAR_0113574
    ----see VAR_0113572 T P mis40--------

    HapMap Linkage Disequilibrium report for MT-ND5 (12337 - 14148 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MT-ND5: --
    Human Gene Mutation Database (HGMD): MT-ND5
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-ND5
    DNA2.0 Custom Variant and Variant Library Synthesis for MT-ND5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 516005    OMIM disorders: --

    UniProtKB/Swiss-Prot: NU5M_HUMAN, P03915
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by
    the presence of focal, bilateral lesions in one or more areas of the central nervous system including the
    brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the
    central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia,
    weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory
    chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset
    neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific
    encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and
    some forms of Parkinson disease. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)
    [MIM:540000]: Genetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent
    cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 16 diseases for MT-ND5:    
    About MalaCards
    melas, mt-nd5-related    merrf syndrome    wolff-parkinson-white syndrome    leigh syndrome due to cytochrome c oxidase deficiency
    leigh syndrome, due to cox deficiency    leber hereditary optic neuropathy    multicentric carpotarsal osteolysis syndrome    leigh syndrome due to mitochondrial cox4 deficiency
    kearns-sayre syndrome    leigh disease    melas syndrome    leigh syndrome due to mitochondrial complex i deficiency
    mitochondrial dna-associated leigh syndrome and narp    mitochondrial disorders    mitochondrial complex i deficiency    parkinson's disease

    4 diseases from the University of Copenhagen DISEASES database for MT-ND5:
    Leber hereditary optic neuropathy     Mitochondrial myopathy     Leigh disease     Lactic acidosis

    Find genes that share disorders with MT-ND5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MT-ND5 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leigh syndrome 82.4 7 11938446 (1), 19349200 (1), 16816025 (1), 18332249 (1) (see all 5)
    mitochondrial diseases 79.7 2 16741938 (1), 17525683 (1)
    lebers hereditary optic neuropathy 78.2 2 8741876 (1), 18396045 (1)
    mitochondrial encephalomyopathies 74.9 2 19617458 (1), 15767514 (1)
    acidosis lactic 66.3 2 19617458 (1), 15767514 (1)
    encephalopathy 59.2 1 18396045 (1)
    merrf 56.9 1 15767514 (1)
    epilepsies myoclonic 55.9 2 15767514 (2)
    somatic mutations 45 1 16404428 (1)
    microsatellite instability 34.6 1 19269084 (1)

    GeneTests: MT-ND5
    GeneReviews: MT-ND5
    Genetic Association Database (GAD): MT-ND5

    Export disorders for MT-ND5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT-ND5 gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with MT-ND5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the ND5 subunit of complex I of the mitochondrial DNA are a frequent cause of oxidative phosphorylation disease. (PubMed id 17400793)1, 2, 4, 9 Blok M.J....Smeets H.J. (J. Med. Genet. 2007)
    2. The role of the ND5 gene in LHON: characterization of a new, heteroplasmic LHON mutation. (PubMed id 16240359)1, 2, 9 Mayorov V.... Brown M.D. (Ann. Neurol. 2005)
    3. Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population. (PubMed id 15975594)1, 4, 9 Huerta C....Alvarez V. (J. Neurol. Sci. 2005)
    4. Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos. (PubMed id 17614984)1, 7 Bao H.G....Wu C.h. (Anim. Genet. 2007)
    5. The mitochondrial 13513G &gt; A mutation is most frequent in Leigh syndrome combined with reduced complex I activity, optic atrophy and/or Wolff-Parkinson-White. (PubMed id 17106447)1, 4 Ruiter E.M....Hol F.A. (Eur. J. Hum. Genet. 2007)
    6. [Association of mitochondrial DNA variation with type 2 diabetes mellitus]. (PubMed id 16331560)1, 4 Tang D.L....Liu S.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    7. Genotyping Parkinson disease-associated mitochondrial polymorphisms. (PubMed id 15931342)1, 4 Jiang Y....Greenlee A.R. (amp 2004)
    8. Leigh syndrome caused by mitochondrial DNA G13513A mutation: frequency and clinical features in Japan. (PubMed id 14730434)1, 4 Sudo A....Goto Y. (J. Hum. Genet. 2004)
    9. Deleted 4977-bp mitochondrial DNA mutation is associated with sporadic amyotrophic lateral sclerosis: a hospital-based case-control study. (PubMed id 14639589)1, 4 Ro L.S....Chen S.T. (amp 2003)
    10. [Mitochondrial DNA mutations and non-syndromic sensorineural hearing loss]. (PubMed id 12772452)1, 4 Kong W....Cheng H. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4540 HGNC: 7461 Ensembl:ENSG00000198786 euGenes: HUgn4540 ECgene: MT-ND5 Kegg: 4540
    H-InvDB: MT-ND5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MT-ND5 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MT-ND5[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT-ND5 gene:
    Search GeneIP for patents involving MT-ND5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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