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MT-ND2 Gene

protein-coding   GIFtS: 45
GCID: GCMTP004472

Mitochondrially Encoded NADH Dehydrogenase 2

(Previous name: NADH dehydrogenase 2)
(Previous symbol: MTND2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrially Encoded NADH Dehydrogenase 21     Complex I ND2 Subunit1
MTND21 2 3     NADH Dehydrogenase 21
ND22 3     NADH-Ubiquinone Oxidoreductase Chain 21
NADH Dehydrogenase Subunit 22 3     NADH23
EC 1.6.5.33 8     

External Ids:    HGNC: 74561   Entrez Gene: 45362   Ensembl: ENSG000001987637   OMIM: 5160015   UniProtKB: P038913   

Export aliases for MT-ND2 gene to outside databases

Previous GC identifers: GC00U921588 GCMTP003310


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-ND2 Gene:
MT-ND2 (mitochondrially encoded NADH dehydrogenase 2) is a protein-coding gene. Diseases associated with MT-ND2 include sporadic breast cancer, and leber hereditary optic neuropathy.

UniProtKB/Swiss-Prot: NU2M_HUMAN, P03891
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)

Gene Wiki entry for MT-ND2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-ND2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-ND2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-ND2


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP004472:       (about GC identifiers)

Start:
4,470 bp from pter      End:
5,511 bp from pter
Size:
1,042 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NU2M_HUMAN, P03891 (See protein sequence)
Recommended Name: NADH-ubiquinone oxidoreductase chain 2  
Size: 347 amino acids; 38961 Da
Sequence caution: Sequence=AAA65502.1; Type=Erroneous initiation;
Secondary accessions: Q34769 Q9TGI0 Q9TGI1 Q9TGI2 Q9TGI3 Q9TGI4

Explore the universe of human proteins at neXtProt for MT-ND2: NX_P03891

Explore proteomics data for MT-ND2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MT-ND2 (P03891) (see all 17)
     WNKLTWL  KMKWQFE  TWQKLAP  LTQATAS 


    See MT-ND2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000355046  
    Reactome Protein details: P03891

    MT-ND2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    3 InterPro protein domains:
     IPR010933 NADH_DH_su2_C
     IPR003917 NADH_UbQ_OxRdtase_chain2
     IPR001750 NADH_UbQ/plastoQ_OxRdtase

    Graphical View of Domain Structure for InterPro Entry P03891

    ProtoNet protein and cluster: P03891

    1 Blocks protein domain: IPB003917 NADH-ubiquinone oxidoreductase chain 2 signature

    UniProtKB/Swiss-Prot: NU2M_HUMAN, P03891
    Similarity: Belongs to the complex I subunit 2 family


    MT-ND2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NU2M_HUMAN, P03891
    Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
    believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
    electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
    ubiquinone (By similarity)
    Catalytic activity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)

         Enzyme Number (IUBMB): EC 1.6.5.31 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity ----
         
    MT-ND2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for mt-Nd2):
     cellular  immune system 

    MT-ND2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT-ND2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT-ND2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT-ND2

    miRNA
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    miRTarBase miRNAs that target MT-ND2:
    hsa-let-7b-5p (MIRT051888), hsa-let-7e-5p (MIRT051443), hsa-mir-296-3p (MIRT038380), hsa-let-7a-5p (MIRT052497), hsa-mir-181a-5p (MIRT047320), hsa-mir-320b (MIRT036193), hsa-mir-760 (MIRT036721), hsa-let-7c-5p (MIRT051736), hsa-mir-17-5p (MIRT050838), hsa-mir-877-5p (MIRT037347), hsa-mir-342-5p (MIRT038220), hsa-mir-148b-3p (MIRT043575)

    Block miRNA regulation of human, mouse, rat MT-ND2 using miScript Target Protectors
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NU2M_HUMAN, P03891: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane3
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane ----
    GO:0005747mitochondrial respiratory chain complex I ----
    GO:0016021integral component of membrane ----

    MT-ND2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT-ND2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Oxidative phosphorylation0.51
    The citric acid (TCA) cycle and respiratory electron transport0.71
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for MT-ND2
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for MT-ND2
        Respiratory electron transport


    3 Kegg Pathways  (Kegg details for MT-ND2):
        Oxidative phosphorylation
    Metabolic pathways
    Parkinson's disease


    MT-ND2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-ND2
    Interactions:

        Search GeneGlobe Interaction Network for MT-ND2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MT-ND2 (P038913 ENSP000003550464) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    CDC42P609533I2D: score=2 
    FOSP011003I2D: score=2 
    MAPK14Q165393I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone ----
    GO:0022904respiratory electron transport chain ----
    GO:0044237cellular metabolic process ----
    GO:0044281small molecule metabolic process ----
    GO:0055114oxidation-reduction process ----

    MT-ND2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT-ND2 (NU2M)

    9 HMDB Compounds for MT-ND2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinol 8ubiquinol-8 (see all 2)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for MT-ND2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8targetbinder17139284 11752352 17016423 15700717 12882707

    7 Novoseek inferred chemical compound relationships for MT-ND2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 83.8 38 15888325 (2), 8833408 (2), 1370613 (1), 9593315 (1) (see all 26)
    valine 30.9 1 1732158 (1)
    methionine 18.3 1 1732158 (1)
    threonine 16.9 1 1732158 (1)
    alanine 5.96 1 1732158 (1)
    oxygen 0 1 17456604 (1)
    lipid 0 1 16266403 (1)



    MT-ND2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361453

    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat MT-ND2

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT-ND2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT-ND2 Expression
    About this image

    MT-ND2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT-ND2 Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MT-ND2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia mt-Nd25
    ND21
    mitochondrially encoded NADH dehydrogenase 25
    ND21
    62.84(n)1
    59.94(a)1
      MT5
    177171  ND2_345385991  NP_904329.11 
     39145 
    chicken
    (Gallus gallus)
    Aves ND21 ND2 60.04(n)
    51.24(a)
      807645  ND2_5834845  NP_006916.1 
    lizard
    (Anolis carolinensis)
    Reptilia ND26
    NADH dehydrogenase subunit 2 (mitochondrion)
    47(a)
    1 ↔ 1
    MT(3841-4876)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ND21 ND2 57.95(n)
    52.03(a)
      3283493  ND2_58618666  YP_203371.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ND21 ND2 53.48(n)
    46.11(a)
      140532  ND2_8395613  NP_059332.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ND21 ND2 50.13(n)
    44.7(a)
      192474  ND2_5835234  NP_008277.1 


    ENSEMBL Gene Tree for MT-ND2 (if available)
    TreeFam Gene Tree for MT-ND2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT-ND2 gene
    4 SIMAP similar genes for MT-ND2 using alignment to 1 protein entry:     NU2M_HUMAN:
    NADH2    clone 82-2    ndh2    ND2

    MT-ND2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MT-ND2 (see all 38)
    PGOHUM00000238521 PGOHUM00000238684 PGOHUM00000242450 PGOHUM00000239418 PGOHUM00000248705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MT-ND2 (see all 21)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr MT posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0047554
    Leber hereditary optic neuropathy (LHON)4--see VAR_0047552 N D mis40--------
    VAR_0047564
    Leber hereditary optic neuropathy (LHON)4--see VAR_0047562 G S mis40--------
    VAR_0047584
    Alzheimer disease mitochondrial (AD-MT)4--see VAR_0047582 A S mis40--------
    VAR_0085924
    ----see VAR_0085922 Q R mis40--------
    VAR_0085914
    ----see VAR_0085912 I T mis40--------
    VAR_0113534
    ----see VAR_0113532 A V mis40--------
    VAR_0113514
    ----see VAR_0113512 L M mis40--------
    VAR_0085904
    ----see VAR_0085902 P L mis40--------
    VAR_0113544
    ----see VAR_0113542 I T mis40--------
    VAR_0085944
    ----see VAR_0085942 S P mis40--------

    HapMap Linkage Disequilibrium report for MT-ND2 (4470 - 5511 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MT-ND2: --
    Human Gene Mutation Database (HGMD): MT-ND2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-ND2
    DNA2.0 Custom Variant and Variant Library Synthesis for MT-ND2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 516001    OMIM disorders: --

    UniProtKB/Swiss-Prot: NU2M_HUMAN, P03891
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Alzheimer disease mitochondrial (AD-MT) [MIM:502500]: Alzheimer disease is a neurodegenerative disorder
    characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins
    as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major
    constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from
    the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments
    (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry

  • Selected diseases for MT-ND2 (see all 39):    About MalaCards
    sporadic breast cancer    leber hereditary optic neuropathy    optic neuritis    mitochondrial dna-associated leigh syndrome and narp
    neuritis    age related macular degeneration    leigh disease    acne
    mitochondrial complex i deficiency    mitochondrial disorders    multiple myeloma    breast disease
    pulmonary function    peripheral neuropathy    oral cancer    bipolar disorder
    acute myocardial infarction    nasopharyngitis    neuropathy    alzheimer's disease


    MT-ND2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MT-ND2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 34.3 1 16404428 (1)
    cancer 0 1 12679003 (1)

    GeneTests: MT-ND2
    GeneReviews: MT-ND2
    Genetic Association Database (GAD): MT-ND2

    Export disorders for MT-ND2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT-ND2 gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with MT-ND2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men. (PubMed id 15888325)1, 4, 9 Kokaze A....Takashima Y. (Mech. Ageing Dev. 2005)
    2. Association of a 5178C--&gt;A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. (PubMed id 15262184)1, 4, 9 Takagi K....Tanaka M. (Atherosclerosis 2004)
    3. The association of mitochondrial DNA 5178 C &gt; a polymorphism with plasma lipid levels among three ethnic groups. (PubMed id 16266403)1, 4, 9 Lal S....Heng C.K. (Ann. Hum. Genet. 2005)
    4. Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases. (PubMed id 17541740)1, 4 Ye C....Cai Q. (Breast Cancer Res. Treat. 2008)
    5. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men. (PubMed id 17510502)1, 4 Kokaze A....Takashima Y. (Hypertens. Res. 2007)
    6. Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men. (PubMed id 17277043)1, 4 Dhillon V.S....Husain S.A. (Mol. Hum. Reprod. 2007)
    7. Mitochondrial DNA 4977 BP deletion mutations in lung carcinoma. (PubMed id 16763358)1, 4 Dai J.G....Zhou R.J. (Indian J Cancer 2006)
    8. ALDH2 polymorphisms and bone mineral density in an elderly Japanese population. (PubMed id 16520888)1, 4 Yamaguchi J....Hamajima N. (Osteoporos Int 2006)
    9. Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease. (PubMed id 16784756)1, 4 Swerdlow R.H....Worrall B.B. (J. Neurol. Sci. 2006)
    10. Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men. (PubMed id 16897192)1, 4 Kokaze A....Takashima Y. (J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4536 HGNC: 7456 Ensembl:ENSG00000198763 euGenes: HUgn4536 ECgene: MT-ND2 Kegg: 4536
    H-InvDB: MT-ND2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT-ND2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MT-ND2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT-ND2 gene:
    Search GeneIP for patents involving MT-ND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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