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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT-ND1 Gene

protein-coding   GIFtS: 45
GCID: GCMTP003309

Mitochondrially Encoded NADH Dehydrogenase 1

(Previous name: NADH dehydrogenase 1)
(Previous symbol: MTND1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrially Encoded NADH Dehydrogenase 11     Complex I ND1 Subunit1
MTND11 2 3     NADH Dehydrogenase 11
ND12 3     NADH-Ubiquinone Oxidoreductase Chain 11
NADH Dehydrogenase Subunit 12 3     NADH Dehydrogenase, Subunit 1 (Complex I)2
EC 1.6.5.33 8     NADH13

External Ids:    HGNC: 74551   Entrez Gene: 45352   Ensembl: ENSG000001988887   OMIM: 5160005   UniProtKB: P038863   

Export aliases for MT-ND1 gene to outside databases

Previous GC identifer: GC00U921587


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MT-ND1 Gene: 
MT-ND1 (mitochondrially encoded NADH dehydrogenase 1) is a protein-coding gene. Diseases associated with MT-ND1 include phlebotomus fever, and melas, mt-nd1-related, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include protein binding and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NU1M_HUMAN, P03886
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)

Gene Wiki entry for MT-ND1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MT-ND1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MT-ND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-ND1


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP003309:       (about GC identifiers)

Start:
3,307 bp from pter      End:
4,262 bp from pter
Size:
956 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NU1M_HUMAN, P03886 (See protein sequence)
Recommended Name: NADH-ubiquinone oxidoreductase chain 1  
Size: 318 amino acids; 35661 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q37523

Explore the universe of human proteins at neXtProt for MT-ND1: NX_P03886

Explore proteomics data for MT-ND1 at MOPED 

4/30 DME Specific Peptides for MT-ND1 (P03886) (see all 30)
 WPLAMMW  LLMSGSF  NLGLLFI  LAIILLS 

MT-ND1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MT-ND1 Protein Expression

ENSEMBL proteins: 
 ENSP00000354687  
Reactome Protein details: P03886
Human Recombinant Protein Products for MT-ND1: 
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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane ----
GO:0005747mitochondrial respiratory chain complex I ----
GO:0016020membrane ----
GO:0016021integral to membrane ----

MT-ND1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
comI: Mitochondrial respiratory chain complex / Complex I

2 InterPro protein domains:
 IPR018086 NADH_UbQ_OxRdtase_su1_CS
 IPR001694 NADH_UbQ_OxRdtase_su1/FPO

Graphical View of Domain Structure for InterPro Entry P03886

ProtoNet protein and cluster: P03886

1 Blocks protein domain: IPB001694 Respiratory-chain NADH dehydrogenase

UniProtKB/Swiss-Prot: NU1M_HUMAN, P03886
Similarity: Belongs to the complex I subunit 1 family


MT-ND1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NU1M_HUMAN, P03886
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)
Catalytic activity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)

     Enzyme Number (IUBMB): EC 1.6.5.31 2

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008137NADH dehydrogenase (ubiquinone) activity ----
     
MT-ND1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for MT-ND1:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MT-ND1 
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Inhib. RNA
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MT-ND1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
Oxidative phosphorylation0.64
Respiratory electron transport0.81
Parkinson's disease0.61
Electron Transport Chain0.75
Oxidative phosphorylation0.51
The citric acid (TCA) cycle and respiratory electron transport0.72
2Metabolism
Metabolism0.40
Metabolic pathways0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for MT-ND1
    Electron Transport Chain
Oxidative phosphorylation

4        Reactome Pathways for MT-ND1
    Respiratory electron transport
Metabolism
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport


3         Kegg Pathways  (Kegg details for MT-ND1):
    Oxidative phosphorylation
Metabolic pathways
Parkinson's disease


MT-ND1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-ND1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/62 Interacting proteins for MT-ND1 (P038862, 3 ENSP000003546874) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
InteractantInteraction Details
GeneCardExternal ID(s)
NAMPTP434902, 3, ENSP000002225534MINT-6538787 MINT-6538841 MINT-6538697 I2D: score=1 STRING: ENSP00000222553
NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
NDUFA9Q167952, ENSP000002665444MINT-4981243 STRING: ENSP00000266544
NDUFS5O439202, ENSP000003620584MINT-4981243 STRING: ENSP00000362058
DHDDSQ86SQ93, ENSP000003531044I2D: score=1 STRING: ENSP00000353104
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006120mitochondrial electron transport, NADH to ubiquinone ----
GO:0022904respiratory electron transport chain ----
GO:0044237cellular metabolic process ----
GO:0044281small molecule metabolic process ----
GO:0055114oxidation-reduction process ----

MT-ND1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MT-ND1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MT-ND1 (NU1M)

9 HMDB Compounds for MT-ND1    About this table
CompoundSynonyms CAS #PubMed Ids
FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
IronArmco iron (see all 19)7439-89-6--
NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
QH2CoQH2 (see all 5)56275-39-9--
SulfideSulfide (see all 4)18496-25-8--
Ubiquinol 8ubiquinol-8 (see all 2)56275-39-9--
Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

8 DrugBank Compounds for MT-ND1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7targetinhibitor17139284 17016423 12411515
Isoflurane-- 26675-46-7enzymeinhibitor17139284 17016423 12411515
NADHbeta-DPNH (see all 18)606-68-8targetbinder17139284 11752352 17016423
DesfluraneDesflurano [INN-Spanish] (see all 2)57041-67-5targetunknown17139284 17016423
EnfluraneAnesthetic 347 (see all 7)13838-16-9targetunknown17139284 17016423
MethoxyfluraneMethoflurane (see all 11)76-38-0targetunknown17139284 17016423
SevofluraneSevofluran (see all 3)28523-86-6targetunknown17139284 17016423
N-Formylmethionine-- --target--10592235

10/13 Novoseek inferred chemical compound relationships for MT-ND1 gene (see all 13)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nadh 81.2 32 18239645 (2), 12615166 (1), 16828917 (1), 9821460 (1) (see all 28)
rotenone 64.1 1 9452319 (1)
solium 44.6 1 15727073 (1)
valine 29.4 1 8741876 (1)
atp 27.8 3 15639345 (1), 16239372 (1), 18369641 (1)
proline 20.8 3 2018041 (1), 15977098 (1), 16828917 (1)
pyruvate 18.7 1 8706709 (1)
threonine 15 1 1928099 (1)
methionine 3.27 1 8741876 (1)
glucose 0 4 10426366 (3)

Search CenterWatch for drugs/clinical trials and news about MT-ND1 / NU1M

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000361390

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MT-ND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MT-ND1 Expression
About this image


See MT-ND1 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for MT-ND1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-ND1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-ND1 gene from 8/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia mt-Nd15
ND11
mitochondrially encoded NADH dehydrogenase 15
NADH dehydrogenase subunit 11
72.12(n)1
77.56(a)1
  MT5
177161  ND1_345385981  NP_904328.11 
 27515 
chicken
(Gallus gallus)
Aves ND11 NADH dehydrogenase subunit 1 69.64(n)
70.7(a)
  807636  ND1_5834844  NP_006915.1 
lizard
(Anolis carolinensis)
Reptilia ND16
NADH dehydrogenase subunit 1 (mitochondrion)
67(a)
1 ↔ 1
MT(2673-3633)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.83942 Transcribed sequence with weak similarity to protein more 72.16(n)    CF225690.1 
zebrafish
(Danio rerio)
Actinopterygii ND11 NADH dehydrogenase subunit 1 67.3(n)
66.14(a)
  140531  ND1_8395612  NP_059331.1 
fruit fly
(Drosophila melanogaster)
Insecta ND11 NADH dehydrogenase subunit 1 49.39(n)
49.5(a)
  192473  ND1_5835246  NP_008289.1 
worm
(Caenorhabditis elegans)
Secernentea ND11 NADH dehydrogenase subunit 1 45.2(n)
37.05(a)
  2565698  ND1_5834896  NP_006955.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons ndhA1 NADH dehydrogenase subunit 1 46.51(n)
38.54(a)
  844804  ndhA_7525090  NP_051114.1 


ENSEMBL Gene Tree for MT-ND1 (if available)
TreeFam Gene Tree for MT-ND1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MT-ND1 gene
3 SIMAP similar genes for MT-ND1 using alignment to 1 protein entry:     NU1M_HUMAN:
NADH1    ROPN1B    ND1

MT-ND1 for paralogs           About GeneDecksing


5/54 Pseudogenes.org Pseudogenes for MT-ND1 (see all 54)
PGOHUM00000238368 PGOHUM00000238409 PGOHUM00000238424 PGOHUM00000238522 PGOHUM00000238687


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/14 SNPs in MT-ND1 are shown (see all 14)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr MT posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0047544
Leber hereditary optic neuropathy (LHON)4--see VAR_0047542 Y H mis40--------
VAR_0047514
Leber hereditary optic neuropathy (LHON)4--see VAR_0047512 A T mis40--------
VAR_0047534
Leber hereditary optic neuropathy (LHON)4--see VAR_0047532 L P mis40--------
VAR_0047484
Leber hereditary optic neuropathy (LHON)4--see VAR_0047482 Y H mis40--------
VAR_0047504
Alzheimer disease mitochondrial (AD-MT)4--see VAR_0047502 M V mis40--------
VAR_0047494
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)4--see VAR_0047492 M T mis40--------
VAR_0113474
----see VAR_0113472 T A mis40--------
VAR_0085894
----see VAR_0085892 L P mis40--------
VAR_0085884
----see VAR_0085882 Y C mis40--------
VAR_0047524
----see VAR_0047522 Y C mis40--------

HapMap Linkage Disequilibrium report for MT-ND1 (3307 - 4262 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MT-ND1: --

Human Gene Mutation Database (HGMD): MT-ND1
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 516000    OMIM disorders: --

UniProtKB/Swiss-Prot: NU1M_HUMAN, P03886
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS)
    [MIM:540000]: Genetically heterogeneous disorder, characterized by episodic vomiting, seizures, and recurrent
    cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Alzheimer disease mitochondrial (AD-MT) [MIM:502500]: Alzheimer disease is a neurodegenerative disorder
    characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins
    as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major
    constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from
    the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments
    (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry
  • Note=Genetic variation in MT-ND1 might contribute ot the pathogenesis of non-insulin-dependent diabetes
    mellitus (NIDDM)

  • 20/50 diseases for MT-ND1 (see all 50):    About MalaCards
    phlebotomus fever    melas, mt-nd1-related    fatal infantile lactic acidosis    leber hereditary optic neuropathy
    tinea capitis    melas syndrome    mitochondrial dna-associated leigh syndrome and narp    ischemic optic neuropathy
    left ventricular noncompaction    mitochondrial disorders    lactic acidosis    cortical blindness
    hereditary neuropathies    mitochondrial complex i deficiency    optic neuritis    neuritis
    mitochondrial encephalomyopathy    encephalomyopathy    nonsyndromic deafness    frontotemporal dementia

    1 disease from the University of Copenhagen DISEASES database for MT-ND1:
    Leber hereditary optic neuropathy

    MT-ND1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for MT-ND1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers hereditary optic neuropathy 90.2 6 15505787 (2), 8741876 (1), 7611010 (1), 1928099 (1) (see all 5)
    acidosis lactic 48.9 3 8338207 (1), 16492986 (1)
    hydatid cyst 40.4 1 10363285 (1)
    niddm 36.9 4 8858117 (1), 16828917 (1), 17200023 (1)
    diabetes mellitus 36.1 3 17200023 (1), 12035616 (1), 8723687 (1)
    parkinson disease 33.4 1 11506395 (1)
    cardiomyopathy 17.1 2 18502698 (1), 8723687 (1)
    neurodegenerative diseases 0 1 10854284 (1)

    GeneTests: MT-ND1
    GeneReviews: MT-ND1
    Genetic Association Database (GAD): MT-ND1

    Export disorders for MT-ND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT-ND1 gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with MT-ND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Relationship between mutations of mitochondrial DNA ND1 gene and type 2 diabetes. (PubMed id 15265369)1, 2, 4 Yu P....Tang X.Z. (2004)
    2. [Development of a DNA chip screening mitochondrial DN A mutations in patients with diabetes mellitus] (PubMed id 17200023)1, 4, 9 Liu S.M....Li D. (2006)
    3. Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population. (PubMed id 15975594)1, 4, 9 Huerta C....Alvarez V. (2005)
    4. Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity. (PubMed id 16060290)1, 4, 9 Guo L.J....Tanaka M. (2005)
    5. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PubMed id 17619138)1, 4 Ahari S.E....Bahar M.A. (2007)
    6. A mitochondrial DNA polymorphism associated with cardiac arrhythmia investigated in sudden infant death syndrome. (PubMed id 17429906)1, 4 Arnestad M....Rognum T.O. (2007)
    7. Mitochondrial polymorphisms as risk factors for endometrial cancer in southwest China. (PubMed id 16884381)1, 4 Xu L....Xiao C. (2006)
    8. Mitochondrial D-loop variation in leber hereditary neuropathy patients harboring primary G11778A, G3460A, T14484C mutations: J and W haplogroups as high-risk factors. (PubMed id 17045122)1, 4 Shafa Shariat Panahi M....Tabassi A.R. (2006)
    9. The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216T > C and m.4917A > G variants. (PubMed id 16759180)1, 4 Crispim D....Roisenberg I. (2006)
    10. [Detecting of mtDNA mutations at position A3243G and G3316A in patients with type 2 diabetes mellitus in Wenzhou] (PubMed id 17035175)1, 4 Zhao J....Lu J.X. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4535 HGNC: 7455 Ensembl:ENSG00000198888 euGenes: HUgn4535 ECgene: MT-ND1 Kegg: 4535
    H-InvDB: MT-ND1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT-ND1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MT-ND1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MT-ND1 gene:
    Search GeneIP for patents involving MT-ND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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