MT-CYB Gene
protein-coding GIFtS: 41
GCID: GCMTP014749
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mitochondrially encoded cytochrome b(Previous name: cytochrome b )
(Previous symbol: MTCYB)
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Aliases
for MT-CYB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrially Encoded Cytochrome B1 | | UQCR31 | | CYTB1 2 3 | | Complex III Subunit 33 | | MTCYB1 2 3 | | Complex III Subunit III3 | | Cytochrome B1 2 | | Cytochrome B-C1 Complex Subunit 33 | | COB1 3 | | Ubiquinol-Cytochrome-C Reductase Complex Cytochrome B Subunit3 |
Export aliases for MT-CYB gene to outside databasesPrevious GC identifer: GC00U921586 |
Summaries
for MT-CYB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CYB_HUMAN, P00156Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which isa respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Gene Wiki entry for MT-CYB
|
Genomic Views
for MT-CYB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MT-CYB
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT-CYB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-CYB |
Genomic Location:
Chromosome:MT
Ensembl cytogenetic band: MT HGNC chromosome: mitochondriaGeneLoc information about chromosome MT GeneLoc Exon Structure GeneLoc location for GCMTP014749: view genomic region
(about GC identifiers)
Start:
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14,747 bp from pter |
End:
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15,887 bp from pter |
Size:
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1,141 bases |
Orientation:
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plus strand |
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Proteins
for MT-CYB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CYB_HUMAN, P00156 (See
protein sequence)Recommended Name: Cytochrome b Size: 380 amino acids; 42718 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1),2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8,UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Miscellaneous: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) ishigh-potential and absorbs at about 566 nm (By similarity)
Secondary accessions: Q34786 Q8HBR6 Q8HNQ0 Q8HNQ1 Q8HNQ9 Q8HNR4 Q8HNR7 Q8W7V8 Q8WCV9 Q8WCY2 Q8WCY7Q8WCY8 Q9B1A6 Q9B1B6 Q9B1B8 Q9B1D4 Q9B1X6 Q9B2V0 Q9B2V8 Q9B2W0 Q9B2W3 Q9B2W8 Q9B2X1 Q9B2X7 Q9B2X9Q9B2Y3 Q9B2Z0 Q9B2Z4 Q9T6H6 Q9T9Y0 Q9TEH4Explore the universe of human proteins at neXtProt for MT-CYB: NX_P00156
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P00156
MT-CYB Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000354554 Reactome Protein details: P00156
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
MT-CYB for ontologies About GeneDecksing
MT-CYB Antibody Products:
Assay Products for MT-CYB: |
Protein
Domains /
Families
for MT-CYB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MT-CYB for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P00156ProtoNet protein and cluster: P00156 UniProtKB/Swiss-Prot: CYB_HUMAN, P00156Similarity: Belongs to the cytochrome b family |
Function
for MT-CYB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CYB_HUMAN, P00156Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which isa respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MT-CYB for ontologies About GeneDecksing
|
Pathways & Interactions
for MT-CYB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | | | 3 | Cardiac muscle contraction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for MT-CYB
4 
Reactome Pathways for MT-CYB
5/6 
Kegg Pathways (Kegg details for MT-CYB) (see all 6):
MT-CYB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-CYB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/87 Interacting proteins for MT-CYB (P001563 ENSP000003545544) via UniProtKB, MINT, STRING, and/or I2D (see all 87)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
NAS | 6100559 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
MT-CYB for ontologies About GeneDecksing
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Drugs & Compounds
for MT-CYB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MT-CYB for compounds About GeneDecksing
 Browse Tocris compounds for MT-CYB
1 HMDB Compound for MT-CYB About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
1 DrugBank Compound for MT-CYB About this table
10/72 Novoseek chemical compound relationships for MT-CYB gene (see all 72) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ubiquinol |
79.5 |
20 |
16005845 (4), 10072046 (1), 10971589 (1), 18973379 (1) (see all 10) |
| iron-sulfur |
77.8 |
27 |
15030479 (2), 8394318 (2), 11707449 (2), 8988236 (1) (see all 20) |
| atovaquone |
76 |
22 |
9815231 (2), 11181161 (2), 17118179 (2), 14576156 (1) (see all 12) |
| antimycin a |
74.9 |
26 |
7726562 (2), 19082470 (1), 17935707 (1), 19111365 (1) (see all 13) |
| myxothiazol |
73.1 |
3 |
7726562 (1), 1851092 (1), 8449293 (1) |
| citrinin |
69.9 |
7 |
1851092 (3), 8932536 (1) |
| ubiquinone |
69.6 |
9 |
10416030 (1), 11732343 (1), 19082940 (1), 10072046 (1) (see all 9) |
| nadh |
66.3 |
31 |
9950599 (2), 1854438 (1), 16293425 (1), 18804544 (1) (see all 29) |
| funiculosin |
66.2 |
5 |
1315503 (4), 7957895 (1) |
| stigmatellin |
65.1 |
2 |
1657909 (1), 18258178 (1) |
Search CenterWatch for drugs/clinical trials and news about MT-CYB / CYB
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Transcripts
for MT-CYB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000361789(uc022bqw.1)
GeneLoc Exon Structure
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Expression
for MT-CYB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MT-CYB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MT-CYB Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for MT-CYB
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MT-CYB | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-CYB | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CYB |
Orthologs
for MT-CYB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MT-CYB gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for MT-CYB (if available)
TreeFam Gene Tree for MT-CYB (if available) |
Paralogs
for MT-CYB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MT-CYB gene
6 SIMAP similar genes for MT-CYB using alignment to 1 protein entry: CYB_HUMAN:CYB CytB Cytb cytb CYTB cytB
MT-CYB for paralogs About GeneDecksing
5/59 Pseudogenes.org Pseudogenes for MT-CYB (see all 59)
PGOHUM00000242402 PGOHUM00000242479 PGOHUM00000242516 PGOHUM00000242810 PGOHUM00000242820
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Genomic Variants
for MT-CYB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): MT-CYB
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MT-CYB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MT-CYB for disorders About GeneDecksing
OMIM gene information: 516020
OMIM disorders: --
UniProtKB/Swiss-Prot: CYB_HUMAN, P00156
Note=Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. Theyinclude mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM).In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lacticacidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intoleranceaccompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystemdisorder) Defects in MT-CYB are the cause of cardiomyopathy infantile histiocytoid (CMIH) [MIM:500000]. CMIH ischaracterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affectschildren younger than 2 years of age, with a clear predominance of females over males. Infants present withdysrhythmia or cardiac arrest, and the clinical course is usually fulminant, sometimes simulating sudden infant deathsyndrome Defects in MT-CYB contribute to Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternallyinherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiacconduction defects and neurological defects have also been described in some patients. LHON results from primarymitochondrial DNA mutations affecting the respiratory chain complexes
20/54  diseases for MT-CYB (see all 54): About MalaCardsleber hereditary optic neuropathy kearns-sayre syndrome eastern equine encephalitis sudden infant death syndrome
orthostatic hypotension duchenne muscular dystrophy mitochondrial encephalomyopathy lactic acidosis
myiasis muscular dystrophy hemochromatosis chronic granulomatous disease
pneumocystosis cutaneous leishmaniasis encephalomyopathy oral candidiasis
aspergillosis babesiosis leishmaniasis methemoglobinemia
8 diseases from the University of Copenhagen DISEASES database for MT-CYB:Malaria Chronic granulomatous disease Mitochondrial myopathy Leber hereditary optic neuropathy
Leishmaniasis Chagas disease Eastern equine encephalitis Myiasis 10/19 Novoseek disease relationships for MT-CYB gene (see all 19) About this table
GeneTests: MT-CYB
Leber Hereditary Optic Neuropathy
Genetic Association Database (GAD): MT-CYB
Export disorders for MT-CYB gene to outside databases
|
Publications
for MT-CYB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MT-CYB gene, integrated from 9 sources (see all 382):
(articles sorted by number of sources associating them with MT-CYB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease. (PubMed id 12391595)1, 4, 9 Tanaka M....Yagi K. (2002)
- Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. (PubMed id 10508508)1, 2 Andrews R.M.... Howell N. (1999)
- Serendipitous cloning of a mitochondrial cDNA and its polymorphism. (PubMed id 6100559)1, 2 Spurr N.K. and Bodmer W.F. (1984)
- Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (1981)
- The mtDNA 15497 G/A polymorphism in cytochrome b in severe obese subjects from Southern Italy. (PubMed id 17015183)1, 9 Liguori R....Sacchetti L. (2006)
- Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. (PubMed id 11181161)7, 9 Kazanjian P....Meshnick S.R. (2001)
- Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance. (PubMed id 10802314)7, 9 McFadden D.C....Boothroyd J.C. (2000)
- A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance. (PubMed id 8910895)2, 9 Dumoulin R.... Mousson B. (1996)
- Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HU C-1 cells. (PubMed id 19569044)1, 9 Dasgupta S....Sidransky D. (2009)
- Interaction of mitochondrial thioredoxin with glucoco rticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. (PubMed id 19570036)1, 9 Psarra A.M....Spyrou G. (2009)
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External Searches for MT-CYB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MT-CYB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MT-CYB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT-CYB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MT-CYB | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MT-CYB |
|
| | |
About This Section
| Patent Information for MT-CYB gene:
Search GeneIP for patents involving MT-CYB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MT-CYB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT-CYB | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT-CYB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-CYB | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT-CYB | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CYB | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-CYB |
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| | | | Search Tocris compounds for MT-CYB |
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 | | | MT-CYB Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for MT-CYB |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-CYB |
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