Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


MT-CYB Gene

protein-coding   GIFtS: 45
GCID: GCMTP014749

Mitochondrially Encoded Cytochrome B

(Previous name: cytochrome b)
(Previous symbol: MTCYB)
Microbiology & Infectious Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for MT-CYB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
Mitochondrially Encoded Cytochrome B1     Complex III Subunit 33
MTCYB1 2 3     Complex III Subunit III3
Cytochrome B1 2     Cytochrome B-C1 Complex Subunit 33
CYTB2 3     Ubiquinol-Cytochrome-C Reductase Complex Cytochrome B Subunit3
COB3     

External Ids:    HGNC: 74271   Entrez Gene: 45192   Ensembl: ENSG000001987277   OMIM: 5160205   UniProtKB: P001563   

Export aliases for MT-CYB gene to outside databases

Previous GC identifer: GC00U921586


Summaries
for MT-CYB gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
GeneCards Summary for MT-CYB Gene:
MT-CYB (mitochondrially encoded cytochrome b) is a protein-coding gene. Diseases associated with MT-CYB include mitochondrial respiratory chain complex iii, cytochrome b subunit, and mt-cyb-related recurrent myoglobinuria.

UniProtKB/Swiss-Prot: CYB_HUMAN, P00156
Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),
which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)

Gene Wiki entry for MT-CYB Gene


Genomic Views
for MT-CYB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus		 Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-CYB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-CYB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-CYB


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP014749:       (about GC identifiers)

Start:
 14,747 bp from pter      End:
 15,887 bp from pter
Size:
 1,141 bases      Orientation:
 plus strand

Proteins
for MT-CYB gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: CYB_HUMAN, P00156 (See protein sequence)
Recommended Name: Cytochrome b  
Size: 380 amino acids; 42718 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Miscellaneous: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is
high-potential and absorbs at about 566 nm (By similarity)
Secondary accessions: Q34786 Q8HBR6 Q8HNQ0 Q8HNQ1 Q8HNQ9 Q8HNR4 Q8HNR7 Q8W7V8 Q8WCV9 Q8WCY2
Q8WCY7 Q8WCY8 Q9B1A6 Q9B1B6 Q9B1B8 Q9B1D4 Q9B1X6 Q9B2V0 Q9B2V8 Q9B2W0 Q9B2W3 Q9B2W8 Q9B2X1
Q9B2X7 Q9B2X9 Q9B2Y3 Q9B2Z0 Q9B2Z4 Q9T6H6 Q9T9Y0 Q9TEH4

Explore the universe of human proteins at neXtProt for MT-CYB: NX_P00156

Explore proteomics data for MT-CYB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See MT-CYB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000354554  
    Reactome Protein details: P00156

    MT-CYB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MT-CYB
    GenScript Custom Purified and Recombinant Proteins Services for MT-CYB
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    MT-CYB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MT-CYB
    Novus Biologicals MT-CYB Antibody
    Abcam antibodies for MT-CYB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MT-CYB
    LSBio Antibodies in human, mouse, rat for MT-CYB

    MT-CYB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MT-CYB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MT-CYB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for MT-CYB gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III
    CYB: Cytochrome b genes

    5 InterPro protein domains:
     IPR027387 Cytb/b6-like
     IPR016174 Di-haem_cyt_TM
     IPR005797 Cyt_b/b6_N
     IPR016175 Cyt_b/b6
     IPR005798 Cyt_b/b6_C

    Graphical View of Domain Structure for InterPro Entry P00156

    ProtoNet protein and cluster: P00156

    UniProtKB/Swiss-Prot: CYB_HUMAN, P00156
    Similarity: Belongs to the cytochrome b family


    MT-CYB for domains           About GeneDecksing


    Function
    for MT-CYB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYB_HUMAN, P00156
    Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex),
    which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008121ubiquinol-cytochrome-c reductase activity ----
    GO:0009055electron carrier activity ----
    GO:0016491oxidoreductase activity ----
    GO:0046872metal ion binding ----
         
    MT-CYB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT-CYB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT-CYB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT-CYB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT-CYB

    miRNA
    Products:            		miRTarBase miRNAs that target MT-CYB:
    hsa-mir-140-5p (MIRT045822), hsa-mir-100-5p (MIRT048433), hsa-mir-29a-3p (MIRT049965), hsa-mir-652-3p (MIRT039477), hsa-mir-1301-3p (MIRT035968), hsa-mir-423-3p (MIRT042521), hsa-mir-744-5p (MIRT037484), hsa-mir-186-5p (MIRT045100)

    Block miRNA regulation of human, mouse, rat MT-CYB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MT-CYB
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat MT-CYB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MT-CYB

    Clone
    Products:             		Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MT-CYB
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT-CYB
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-CYB

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MT-CYB
    Browse ESI BIO Cell Lines and PureStem Progenitors for MT-CYB 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CYB


    Localization
    for MT-CYB gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    CYB_HUMAN, P00156: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus3
    plasma membrane3
    chloroplast2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----
    GO:0005750mitochondrial respiratory chain complex III ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    MT-CYB for ontologies           About GeneDecksing


    Pathways & Interactions
    for MT-CYB gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MT-CYB About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    		Oxidative phosphorylation0.64
    		Respiratory electron transport0.81
    		Parkinson's disease0.57
    		Electron Transport Chain0.75
    		Huntington's disease0.45
    		The citric acid (TCA) cycle and respiratory electron transport0.71
    		Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    		Metabolism0.38
    		Metabolic pathways0.38
    3Alzheimer's disease
    		Alzheimer's disease0.44
    4Cardiac muscle contraction
    		Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MT-CYB
        Electron Transport Chain

    1 Reactome Pathway for MT-CYB
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for MT-CYB) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    MT-CYB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-CYB
    Interactions:

        Search GeneGlobe Interaction Network for MT-CYB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MT-CYB (P001563 ENSP000003545544) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UQCRFS1P479853, ENSP000003063974I2D: score=2 STRING: ENSP00000306397
    UPF1Q929003, ENSP000002628034I2D: score=1 STRING: ENSP00000262803
    CYC1P085743, ENSP000003171594I2D: score=5 STRING: ENSP00000317159
    MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
    OXA1LQ150703, ENSP000002858484I2D: score=1 STRING: ENSP00000285848
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006122mitochondrial electron transport, ubiquinol to cytochrome c ----
    GO:0022904respiratory electron transport chain ----
    GO:0044237cellular metabolic process ----
    GO:0044281small molecule metabolic process ----

    MT-CYB for ontologies           About GeneDecksing



    Drugs & Compounds
    for MT-CYB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT-CYB (CYB)

    1 HMDB Compound for MT-CYB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    1 DrugBank Compound for MT-CYB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Atovaquone-- 95233-18-4targetinhibitor10593174 10447880 10681344 11181161 11906048 10802314 15718226 12791689 18082162 11991686

    Selected Novoseek inferred chemical compound relationships for MT-CYB gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ubiquinol 79.5 20 16005845 (4), 10072046 (1), 10971589 (1), 18973379 (1) (see all 10)
    iron-sulfur 77.8 27 15030479 (2), 8394318 (2), 11707449 (2), 8988236 (1) (see all 20)
    atovaquone 76 22 9815231 (2), 11181161 (2), 17118179 (2), 14576156 (1) (see all 12)
    antimycin a 74.9 26 7726562 (2), 19082470 (1), 17935707 (1), 19111365 (1) (see all 13)
    myxothiazol 73.1 3 7726562 (1), 1851092 (1), 8449293 (1)
    citrinin 69.9 7 1851092 (3), 8932536 (1)
    ubiquinone 69.6 9 10416030 (1), 11732343 (1), 19082940 (1), 10072046 (1) (see all 9)
    nadh 66.3 31 9950599 (2), 1854438 (1), 16293425 (1), 18804544 (1) (see all 29)
    funiculosin 66.2 5 1315503 (4), 7957895 (1)
    stigmatellin 65.1 2 1657909 (1), 18258178 (1)



    MT-CYB for compounds           About GeneDecksing



    Transcripts
    for MT-CYB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361789(uc022bqw.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat MT-CYB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MT-CYB
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse OriGene RNAi
    Predesigned siRNA for gene silencing in human, mouse, rat MT-CYB
    Clone
    Products:             		Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MT-CYB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT-CYB
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-CYB
    Primer
    Products:            		Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MT-CYB
      QuantiTect SYBR Green Assays in human, mouse, rat MT-CYB
      QuantiFast Probe-based Assays in human, mouse, rat MT-CYB

    GeneLoc Exon Structure


    Expression
    for MT-CYB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MT-CYB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT-CYB Expression
    About this image

    MT-CYB Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    MT-CYB Protein Expression
        Custom PCR Arrays for MT-CYB
    Primer
    Products:    		Browse OriGene qPCR
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MT-CYB
    QuantiTect SYBR Green Assays in human, mouse, rat MT-CYB
    QuantiFast Probe-based Assays in human, mouse, rat MT-CYB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CYB

    Orthologs
    for MT-CYB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MT-CYB gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia mt-Cytb5
    CYTB1    		 mitochondrially encoded cytochrome b5
    CYTB1    		 74.87(n)1
    78.57(a)1    		   MT5
    177111  CYTB_345386101  NP_904340.11 
     141455 
    chicken
    (Gallus gallus)    		 Aves CYTB1 CYTB 73.4(n)
    73.14(a)    		   807641  CYTB_5834855  NP_006926.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CYTB6
    		 cytochrome b (mitochondrion)
    		 71(a)
    		 1 ↔ 1
    		 MT(14068-15207)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.249682 Xenopus laevis transcribed sequence with weak similarity more 75.66(n)    BU152759.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.296262 Transcribed sequence with weak similarity to protein more 76.09(n)    CK400409.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CYTB1 CYTB 60.04(n)
    61.88(a)    		   192472  CYTB_5835245  NP_008288.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ctb-16
    		 Cytochrome b
    		 43(a)
    		 1 ↔ 1
    		 MtDNA(4504-5621) WBGene00000829
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes COB(Q0105)4
    COB1    		 Cytochrome b, mitochondrially encoded subunit of the more4
    COB1    		 52.15(n)1
    49.73(a)1    		   17(36540-43647)4
    8545831, 4  NP_009315.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons cob1 cob 52.03(n)
    49.29(a)    		   814577  cob_13449309  NP_085492.1 


    ENSEMBL Gene Tree for MT-CYB (if available)
    TreeFam Gene Tree for MT-CYB (if available)

    Paralogs
    for MT-CYB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MT-CYB gene
    6 SIMAP similar genes for MT-CYB using alignment to 1 protein entry:     CYB_HUMAN:
    CYB    CytB    Cytb    cytb    CYTB    cytB

    MT-CYB for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MT-CYB (see all 59)
    PGOHUM00000242402 PGOHUM00000242479 PGOHUM00000242516 PGOHUM00000242810 PGOHUM00000242820


    Genomic Variants
    for MT-CYB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for MT-CYB (see all 39)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr MT posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0136564
    		Cardiomyopathy, infantile histiocytoid (CMIH)4--see VAR_0136562 G D mis40--------
    VAR_0083884
    		Colorectal cancer4--see VAR_0083882 R H mis40--------
    VAR_0083894
    		Colorectal cancer4--see VAR_0083892 F L mis40--------
    VAR_0021974
    		Leber hereditary optic neuropathy (LHON)4--see VAR_0021972 D N mis40--------
    VAR_0021994
    		Leber hereditary optic neuropathy (LHON)4--see VAR_0021992 V M mis40--------
    VAR_0155724
    		----see VAR_0155722 I V mis40--------
    rs30883091,2,4
    		----see VAR_0136552 mis40--------
    VAR_0155714
    		----see VAR_0155712 A T mis40--------
    VAR_0136654
    		----see VAR_0136652 I V mis40--------
    VAR_0136664
    		----see VAR_0136662 V M mis40--------

    HapMap Linkage Disequilibrium report for MT-CYB (14747 - 15887 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MT-CYB: --
    Human Gene Mutation Database (HGMD): MT-CYB
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-CYB
    DNA2.0 Custom Variant and Variant Library Synthesis for MT-CYB

    Disorders / Diseases
    for MT-CYB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 516020    OMIM disorders: --

    UniProtKB/Swiss-Prot: CYB_HUMAN, P00156
  • Note=Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies.
    They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial
    myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features
    include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of
    exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth
    retardation, epilepsy (multisystem disorder)
  • Cardiomyopathy, infantile histiocytoid (CMIH) [MIM:500000]: A heart disease characterized by the presence
    of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2
    years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac
    arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting distinct genetic
    loci, including the gene represented in this entry

    • Selected diseases for MT-CYB (see all 67):    
    About MalaCards
    mitochondrial respiratory chain complex iii, cytochrome b subunit    mt-cyb-related recurrent myoglobinuria    pneumocystosis    myiasis
    hepatoerythropoietic porphyria    eastern equine encephalitis    cutaneous leishmaniasis    babesiosis
    leber hereditary optic neuropathy    chronic granulomatous disease    oral candidiasis    methemoglobinemia
    mitochondrial complex iii deficiency, nuclear type 6    kearns-sayre syndrome    leishmaniasis    septo-optic dysplasia
    hemochromatosis    aspergillosis    melas syndrome    duchenne muscular dystrophy

    7 diseases from the University of Copenhagen DISEASES database for MT-CYB:
    Malaria     Chronic granulomatous disease     Mitochondrial myopathy     Leber hereditary optic neuropathy
    Leishmaniasis     Chagas disease     Myiasis

    MT-CYB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MT-CYB gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    granulomatous disease chronic 75.9 18 8101486 (2), 1323464 (2), 2243141 (1), 1655460 (1) (see all 15)
    malaria avian 67.1 2 15812672 (1), 15791538 (1)
    lebers hereditary optic neuropathy 48.5 1 1764087 (1)
    iron deficiency 26 2 16137899 (1), 12949720 (1)
    malaria 22.2 5 16159551 (1), 19436742 (1), 14965906 (1), 15917236 (1) (see all 5)
    leishmaniasis cutaneous 20.9 1 18271802 (1)
    myopathy 14 1 14977419 (1)
    hereditary hemochromatosis 8.96 1 16137899 (1)
    parkinson disease 5.51 5 12375058 (2), 12391595 (1)
    aids 4.41 2 11181161 (2)

    GeneTests: MT-CYB
    GeneReviews: MT-CYB
    Genetic Association Database (GAD): MT-CYB

    Export disorders for MT-CYB gene to outside databases

    Publications
    for MT-CYB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for MT-CYB gene, integrated from 10 sources (see all 383):
    (articles sorted by number of sources associating them with MT-CYB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The mtDNA 15497 G/A polymorphism in cytochrome b in severe obese subjects from Southern Italy. (PubMed id 17015183)1, 4, 9 Liguori R....Sacchetti L. (Nutr Metab Cardiovasc Dis 2006)
    2. Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease. (PubMed id 12391595)1, 4, 9 Tanaka M....Yagi K. (J. Neurosci. Res. 2002)
    3. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. (PubMed id 10508508)1, 2 Andrews R.M.... Howell N. (Nat. Genet. 1999)
    4. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (Nature 1981)
    5. Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. (PubMed id 11181161)7, 9 Kazanjian P....Meshnick S.R. (J. Infect. Dis. 2001)
    6. Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance. (PubMed id 10802314)7, 9 McFadden D.C....Boothroyd J.C. (Mol. Biochem. Parasitol. 2000)
    7. A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance. (PubMed id 8910895)2, 9 Dumoulin R.... Mousson B. (Mol. Cell. Probes 1996)
    8. Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. (PubMed id 19569044)1, 9 Dasgupta S....Sidransky D. (Int. J. Cancer 2009)
    9. Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. (PubMed id 19570036)1, 9 Psarra A.M....Spyrou G. (Biochem. J. 2009)
    10. The deleterious G15498A mutation in mitochondrial DNA-encoded cytochrome b may remain clinically silent in homoplasmic carriers. (PubMed id 14735157)1, 9 Haut S....Slama A. (Eur. J. Hum. Genet. 2004)

    External Searches for MT-CYB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MT-CYB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4519 HGNC: 7427 Ensembl:ENSG00000198727 euGenes: HUgn4519 ECgene: MT-CYB Kegg: 4519
    H-InvDB: MT-CYB

    Other Databases showing MT-CYB gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing MT-CYB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MT-CYB Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MT-CYB[genesymbol]

    Intellectual Property
    for MT-CYB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for MT-CYB gene:
    Search GeneIP for patents involving MT-CYB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MT-CYB gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   Browse OriGene RNAi products  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   Browse OriGene clones  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MT-CYB   OriGene Custom Protein Services for MT-CYB  

         		 
     Block miRNA regulation of human, mouse, rat MT-CYB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MT-CYB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-CYB Predesigned siRNA for gene silencing in human, mouse, rat MT-CYB
     QuantiFast Probe-based Assays in human, mouse, rat MT-CYB QuantiTect SYBR Green Assays in human, mouse, rat MT-CYB
     Custom PCR Arrays for MT-CYB Search Chromatin IP Primers for MT-CYB
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MT-CYB Search GeneGlobe Interaction Network for MT-CYB
     Search Regulatory tfbs for MT-CYB
     GenScript Custom Purified and Recombinant Proteins Services for MT-CYB GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MT-CYB
     GenScript Custom Assay Services for MT-CYB GenScript Custom overexpressing Cell Line Services for MT-CYB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MT-CYB (CYB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MT-CYB antibodies
     Antibodies for MT-CYB
     See all of Abcam's Antibodies, Kits and Proteins for MT-CYB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MT-CYB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CYB
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MT-CYB
     Browse SwitchGear Promoter luciferase reporter plasmids for MT-CYB
     ThermoFisher Antibodies for MT-CYB
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-CYB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MT-CYB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MT-CYB
     LSBio Antibodies in human, mouse, rat for MT-CYB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MT-CYB gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4