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MT-CYB Gene(Protein Coding)

Mitochondrially Encoded Cytochrome B

GCID:
GCMTP014749
GIFtS:
49
Genes Participants
UDN Logo

Aliases for MT-CYB Gene

Aliases for MT-CYB Gene

  • Mitochondrially Encoded Cytochrome B 2 5
  • Cytochrome B 2 3
  • MTCYB 3 4
  • CYTB 3 4
  • Ubiquinol-Cytochrome-C Reductase Complex Cytochrome B Subunit 4
  • Cytochrome B-C1 Complex Subunit 3 4
  • Complex III Subunit III 4
  • Complex III Subunit 3 4
  • Cob 4

External Ids for MT-CYB Gene

Previous HGNC Symbols for MT-CYB Gene

  • MTCYB

Previous GeneCards Identifiers for MT-CYB Gene

  • GC00U921586

Summaries for MT-CYB Gene

GeneCards Summary for MT-CYB Gene

MT-CYB (Mitochondrially Encoded Cytochrome B) is a Protein Coding gene. Diseases associated with MT-CYB include Infantile Histiocytoid Cardiomyopathy and Leber Hereditary Optic Neuropathy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include oxidoreductase activity and ubiquinol-cytochrome-c reductase activity.

UniProtKB/Swiss-Prot for MT-CYB Gene

  • Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Wiki entry for MT-CYB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-CYB Gene

Genomics for MT-CYB Gene

Products:

  1. Regulatory Element

Genomic Location for MT-CYB Gene

Chromosome:
MT
Start:
14,747 bp from pter
End:
15,887 bp from pter
Size:
1,141 bases
Orientation:
Plus strand

Genomic View for MT-CYB Gene

Genes around MT-CYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-CYB Gene

No data available for Regulatory Elements for MT-CYB Gene

Proteins for MT-CYB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MT-CYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00156-CYB_HUMAN
    Recommended name:
    Cytochrome b
    Protein Accession:
    P00156
    Secondary Accessions:
    • Q34786
    • Q8HBR6
    • Q8HNQ0
    • Q8HNQ1
    • Q8HNQ9
    • Q8HNR4
    • Q8HNR7
    • Q8W7V8
    • Q8WCV9
    • Q8WCY2
    • Q8WCY7
    • Q8WCY8
    • Q9B1A6
    • Q9B1B6
    • Q9B1B8
    • Q9B1D4
    • Q9B1X6
    • Q9B2V0
    • Q9B2V8
    • Q9B2W0
    • Q9B2W3
    • Q9B2W8
    • Q9B2X1
    • Q9B2X7
    • Q9B2X9
    • Q9B2Y3
    • Q9B2Z0
    • Q9B2Z4
    • Q9T6H6
    • Q9T9Y0
    • Q9TEH4

    Protein attributes for MT-CYB Gene

    Size:
    380 amino acids
    Molecular mass:
    42718 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
    Miscellaneous:
    • Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.

neXtProt entry for MT-CYB Gene

Proteomics data for MT-CYB Gene at MOPED

Protein Expression for MT-CYB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MT-CYB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT-CYB Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MT-CYB Gene

Domains & Families for MT-CYB Gene

Gene Families for MT-CYB Gene

HGNC:

Protein Domains for MT-CYB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MT-CYB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00156

UniProtKB/Swiss-Prot:

CYB_HUMAN :
  • Belongs to the cytochrome b family.
Family:
  • Belongs to the cytochrome b family.
genes like me logo Genes that share domains with MT-CYB: view

Function for MT-CYB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MT-CYB Gene

UniProtKB/Swiss-Prot Function:
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Human Phenotype Ontology for MT-CYB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for MT-CYB Gene

miRTarBase miRNAs that target MT-CYB

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MT-CYB Gene

Localization for MT-CYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-CYB Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-CYB Gene COMPARTMENTS Subcellular localization image for MT-CYB gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
chloroplast 3
nucleus 3
cytosol 2
extracellular 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MT-CYB Gene

Pathways & Interactions for MT-CYB Gene

genes like me logo Genes that share pathways with MT-CYB: view

Gene Ontology (GO) - Biological Process for MT-CYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007584 response to nutrient IEA --
GO:0009408 response to heat IEA --
GO:0014070 response to organic cyclic compound IEA --
GO:0015992 proton transport IEA --
GO:0033590 response to cobalamin IEA --
genes like me logo Genes that share ontologies with MT-CYB: view

No data available for SIGNOR curated interactions for MT-CYB Gene

Drugs & Compounds for MT-CYB Gene

Products:

  1. Drug

(37) Drugs for MT-CYB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atovaquone Approved Pharma Target, inhibitor 36
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE Experimental Pharma Target 0
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Experimental Pharma Target 0
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE Experimental Pharma Target 0
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE Experimental Pharma Target 0

(45) Additional Compounds for MT-CYB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MT-CYB: view

Transcripts for MT-CYB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MT-CYB Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-CYB Gene

No ASD Table

Relevant External Links for MT-CYB Gene

GeneLoc Exon Structure for
MT-CYB
ECgene alternative splicing isoforms for
MT-CYB

Expression for MT-CYB Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MT-CYB Gene

mRNA expression in normal human tissues for MT-CYB Gene
mRNA expression by GTEx for MT-CYB Gene

mRNA differential expression in normal tissues according to GTEx for MT-CYB Gene

This gene is overexpressed in Heart - Left Ventricle (x4.3).

Protein differential expression in normal tissues from HIPED for MT-CYB Gene

This gene is overexpressed in Heart (16.5) and Retina (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MT-CYB Gene



genes like me logo Genes that share expression patterns with MT-CYB: view

Protein tissue co-expression partners for MT-CYB Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MT-CYB Gene

Orthologs for MT-CYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CYB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CYTB 35
  • 73 (n)
  • 78.1 (a)
MT-CYB 36
  • 79 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CYTB 35
  • 74.76 (n)
  • 82.06 (a)
MT-CYB 36
  • 83 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia CYTB 35
  • 74.87 (n)
  • 78.57 (a)
mt-Cytb 16
mt-Cytb 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CYTB 35
  • 88.42 (n)
  • 92.11 (a)
MT-CYB 36
  • 93 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia CYTB 35
  • 75.99 (n)
  • 77.84 (a)
oppossum
(Monodelphis domestica)
 Mammalia CYTB 36
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CYTB 36
  • 74 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CYTB 35
  • 73.4 (n)
  • 73.14 (a)
MT-CYB 36
  • 72 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CYTB 36
  • 71 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia CYTB 35
  • 71.77 (n)
  • 73.09 (a)
Str.8624 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24968 35
zebrafish
(Danio rerio)
 Actinopterygii CYTB 35
  • 69.04 (n)
  • 69.47 (a)
Dr.29626 35
mt-cyb 36
  • 70 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta CYTB 35
  • 59.66 (n)
  • 62.77 (a)
fruit fly
(Drosophila melanogaster)
 Insecta CYTB 35
  • 60.04 (n)
  • 61.88 (a)
mt:Cyt-b 36
  • 60 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea ctb-1 36
  • 43 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AMI008W 35
  • 53.96 (n)
  • 51.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes CYTB 35
  • 53.53 (n)
  • 51.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes COB 35
  • 52.15 (n)
  • 49.73 (a)
BI4 36
  • 24 (a)
 OneToMany
COB 36
  • 42 (a)
 OneToMany
COB 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons cob 35
  • 52.03 (n)
  • 49.29 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes cob 35
  • 52.1 (n)
  • 49.33 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 51 (a)
 OneToOne
Species with no ortholog for MT-CYB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MT-CYB Gene

ENSEMBL:
Gene Tree for MT-CYB (if available)
TreeFam:
Gene Tree for MT-CYB (if available)

Paralogs for MT-CYB Gene

(6) SIMAP similar genes for MT-CYB Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MT-CYB Gene

genes like me logo Genes that share paralogs with MT-CYB: view

No data available for Paralogs for MT-CYB Gene

Variants for MT-CYB Gene

Sequence variations from dbSNP and Humsavar for MT-CYB Gene

SNP ID Clin Chr MT pos Sequence Context AA Info Type
VAR_002197 Leber hereditary optic neuropathy (LHON)
VAR_002198 -
VAR_002199 Leber hereditary optic neuropathy (LHON)
VAR_008388 Colorectal cancer
VAR_008389 Colorectal cancer

Relevant External Links for MT-CYB Gene

Human Gene Mutation Database (HGMD)
MT-CYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-CYB Gene

Disorders for MT-CYB Gene

MalaCards: The human disease database

(27) MalaCards diseases for MT-CYB Gene - From: ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
infantile histiocytoid cardiomyopathy
  • foamy myocardial transformation of infancy
leber hereditary optic neuropathy
  • leber optic atrophy
mitochondrial complex iii deficiency
  • complex 3 mitochondrial respiratory chain deficiency
mitochondrial respiratory chain complex iii, cytochrome b subunit
  • cytochrome b of complex iii
mt-cyb-related recurrent myoglobinuria
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CYB_HUMAN
  • Cardiomyopathy, infantile histiocytoid (CMIH) [MIM:500000]: A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. {ECO:0000269 PubMed:10960495}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO:0000269 PubMed:1732158}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
  • Note=Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). {ECO:0000269 PubMed:11047755, ECO:0000269 PubMed:11601507}.

Relevant External Links for MT-CYB

Genetic Association Database (GAD)
MT-CYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT-CYB
genes like me logo Genes that share disorders with MT-CYB: view

No data available for Genatlas for MT-CYB Gene

Publications for MT-CYB Gene

  1. The mtDNA 15497 G/A polymorphism in cytochrome b in severe obese subjects from Southern Italy. (PMID: 17015183) Liguori R. … Sacchetti L. (Nutr Metab Cardiovasc Dis 2006) 3 23 48 67
  2. The deleterious G15498A mutation in mitochondrial DNA-encoded cytochrome b may remain clinically silent in homoplasmic carriers. (PMID: 14735157) Haut S. … Slama A. (Eur. J. Hum. Genet. 2004) 3 23
  3. Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS. (PMID: 11181161) Kazanjian P. … Meshnick S.R. (J. Infect. Dis. 2001) 23 25
  4. Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance. (PMID: 10802314) McFadden D.C. … Boothroyd J.C. (Mol. Biochem. Parasitol. 2000) 23 25
  5. Polymorphisms in the MT-ATP6 and MT-CYB genes in in vitro fertilization failure. (PMID: 24102627) Mao G.H. … Tao S.B. (Mitochondrial DNA 2015) 3

Products for MT-CYB Gene

Sources for MT-CYB Gene

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