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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT-CO3 Gene

protein-coding   GIFtS: 44
GCID: GCMTP009209

Mitochondrially Encoded Cytochrome C Oxidase III

(Previous name: cytochrome c oxidase III)
(Previous symbol: MTCO3)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrially Encoded Cytochrome C Oxidase III1     Cytochrome C Oxidase Subunit III2
MTCO31 2 3     COXIII3
Cytochrome C Oxidase III1 2     Cytochrome C Oxidase Polypeptide III3
COIII2 3     EC 1.9.3.18
COX32     

External Ids:    HGNC: 74221   Entrez Gene: 45142   Ensembl: ENSG000001989387   OMIM: 5160505   UniProtKB: P004143   

Export aliases for MT-CO3 gene to outside databases

Previous GC identifer: GC00U921585


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MT-CO3 Gene: 
MT-CO3 (mitochondrially encoded cytochrome c oxidase III) is a protein-coding gene. Diseases associated with MT-CO3 include mitochondrial myopathy with lactic acidosis, and melas syndrome, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
Function: Subunits I, II and III form the functional core of the enzyme complex

Gene Wiki entry for MT-CO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MT-CO3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MT-CO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-CO3


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP009209:       (about GC identifiers)

Start:
9,207 bp from pter      End:
9,990 bp from pter
Size:
784 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 3  
Size: 261 amino acids; 29951 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q14Y83

Explore the universe of human proteins at neXtProt for MT-CO3: NX_P00414

Explore proteomics data for MT-CO3 at MOPED 

4/8 DME Specific Peptides for MT-CO3 (P00414) (see all 8)
 GFFWAFY  DVVWLFL  EVPLLNT  TGFHGLHV 

MT-CO3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MT-CO3 Protein Expression

ENSEMBL proteins: 
 ENSP00000354982  
Reactome Protein details: P00414
Human Recombinant Protein Products for MT-CO3: 
Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Custom Protein Services for MT-CO3
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005743mitochondrial inner membrane ----
GO:0016020membrane ----
GO:0016021integral to membrane ----

MT-CO3 for ontologies           About GeneDecksing



MT-CO3 Antibody Products: 
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Novus Biologicals MT-CO3 Antibody
Abcam antibodies for MT-CO3
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LSBio Antibodies in human, mouse, rat for MT-CO3 

Assay Products for MT-CO3: 
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Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
comIV: Mitochondrial respiratory chain complex / Complex IV

3 InterPro protein domains:
 IPR024791 Cyt_c/ubiquinol_Oxase_su3
 IPR013833 Cyt_c_oxidase_su3_a-hlx
 IPR000298 Cyt_c_oxidase_su3

Graphical View of Domain Structure for InterPro Entry P00414

ProtoNet protein and cluster: P00414

1 Blocks protein domain: IPB000298 Cytochrome c oxidase

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
Similarity: Belongs to the cytochrome c oxidase subunit 3 family


MT-CO3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: COX3_HUMAN, P00414
Function: Subunits I, II and III form the functional core of the enzyme complex

     Enzyme Number (IUBMB): EC 1.9.3.12

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004129cytochrome-c oxidase activity ----
GO:0015002heme-copper terminal oxidase activity ----
     
MT-CO3 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MT-CO3 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MT-CO3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MT-CO3 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MT-CO3 

miRNA
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Inhib. RNA
Products:
    
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Gene Editing
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                     Customized lentivirus expression plasmids for stable overexpression of MT-CO3 

Cell Line
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Search LifeMap BioReagents cell lines for MT-CO3
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CO3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MT-CO3 About                                                                                                See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
Parkinson's disease0.61
Respiratory electron transport0.81
Huntington's disease0.47
Electron Transport Chain0.75
Alzheimer's disease0.46
The citric acid (TCA) cycle and respiratory electron transport0.72
Non-alcoholic fatty liver disease (NAFLD)0.41
2Metabolism
Metabolism0.40
Metabolic pathways0.40
3Cardiac muscle contraction
Cardiac muscle contraction

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MT-CO3
    Electron Transport Chain

4        Reactome Pathways for MT-CO3
    Respiratory electron transport
Metabolism
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport


5/7         Kegg Pathways  (Kegg details for MT-CO3) (see all 7):
    Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease


MT-CO3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-CO3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for MT-CO3 (P004142, 3 ENSP000003549824) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
InteractantInteraction Details
GeneCardExternal ID(s)
ATP5BP065763, ENSP000002620304I2D: score=1 STRING: ENSP00000262030
MT-ATP6P008463, ENSP000003546324I2D: score=1 STRING: ENSP00000354632
MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
OXA1LQ150703, ENSP000002858484I2D: score=1 STRING: ENSP00000285848
ELANEP082463I2D: score=1 
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006123mitochondrial electron transport, cytochrome c to oxygen ----
GO:0019646aerobic electron transport chain ----
GO:0022904respiratory electron transport chain ----
GO:0044237cellular metabolic process ----
GO:0044281small molecule metabolic process ----

MT-CO3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MT-CO3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MT-CO3 (COX3)

2 DrugBank Compounds for MT-CO3    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Cholic Acid-- 81-25-4target--10592235
N-Formylmethionine-- --target--10592235

4 Novoseek inferred chemical compound relationships for MT-CO3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nadh 58.1 8 18587274 (1), 16861209 (1), 12696067 (1), 1701727 (1) (see all 6)
citrate 40.1 2 16160866 (1)
atp 35.1 7 9623767 (2), 8392708 (1), 15639345 (1), 7533057 (1)
glucose 0 1 18000087 (1)

Search CenterWatch for drugs/clinical trials and news about MT-CO3 / COX3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362079

miRNA
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Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT-CO3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MT-CO3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT-CO3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-CO3
Sirion Biotech Customized lentivirus for stable overexpression of MT-CO3 
                     Customized lentivirus expression plasmids for stable overexpression of MT-CO3 
Primer
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  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-CO3
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CO3

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MT-CO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MT-CO3 Expression
About this image


See MT-CO3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT-CO3
    SABiosciences Custom PCR Arrays for MT-CO3
Primer
Products:
Browse OriGene qPCR
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Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CO3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CO3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CO3 gene from 10/21 species (see all 21)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia mt-Co35
COX31
mitochondrially encoded cytochrome c oxidase III5
cytochrome c oxidase subunit III1
76.25(n)1
85.82(a)1
  MT5
177101  COX3_345386041  NP_904334.11 
 86075 
chicken
(Gallus gallus)
Aves COX31 cytochrome c oxidase subunit III 71.65(n)
73.18(a)
  807637  COX3_166240019  NP_006921.2 
lizard
(Anolis carolinensis)
Reptilia COX36
cytochrome c oxidase subunit III (mitochondrion)
78(a)
1 ↔ 1
MT(8535-9318)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.81552 Transcribed sequence with moderate similarity to protein more 77.03(n)    CF152495.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.249112 Danio rerio cDNA clone MGC73301 IMAGE4787562, complete more 74.23(n)    BC060932.1 
fruit fly
(Drosophila melanogaster)
Insecta COX31 cytochrome c oxidase subunit III 64.61(n)
63.71(a)
  192471  COX3_5835239  NP_008282.1 
worm
(Caenorhabditis elegans)
Secernentea MTCE.236
cytochrome c oxidase subunit III (mitochondrion)
43(a)
1 ↔ 1
MtDNA(5678-6449)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX3(Q0275)4
COX31
Subunit III of cytochrome c oxidase, which is the terminal more4
Cox3p1
49.61(n)1
44.19(a)1
  17(79213-80022)4
8546271, 4  NP_009328.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons cox31 cytochrome c oxidase subunit 3 59.4(n)
57.59(a)
  814601  cox3_26556997  NP_085532.2 
rice
(Oryza sativa)
Liliopsida Os.247412 Transcribed sequence with weak similarity to protein more 73.63(n)    CA762510.1 


ENSEMBL Gene Tree for MT-CO3 (if available)
TreeFam Gene Tree for MT-CO3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MT-CO3 gene
3 SIMAP similar genes for MT-CO3 using alignment to 1 protein entry:     COX3_HUMAN:
CO3    COIII    COX3

MT-CO3 for paralogs           About GeneDecksing


5/63 Pseudogenes.org Pseudogenes for MT-CO3 (see all 63)
PGOHUM00000238688 PGOHUM00000242446 PGOHUM00000242815 PGOHUM00000248440 PGOHUM00000247777


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

8 SNPs in MT-CO3 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr MT posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0021684
Leber hereditary optic neuropathy (LHON)4--see VAR_0021682 A T mis40--------
VAR_0021674
Leber hereditary optic neuropathy (LHON)4--see VAR_0021672 G S mis40--------
VAR_0085754
----see VAR_0085752 V I mis40--------
VAR_0085774
----see VAR_0085772 V I mis40--------
VAR_0021694
----see VAR_0021692 F L mis40--------
VAR_0085764
----see VAR_0085762 Q R mis40--------
VAR_0085744
----see VAR_0085742 F S mis40--------
VAR_0085734
----see VAR_0085732 H R mis40--------

HapMap Linkage Disequilibrium report for MT-CO3 (9207 - 9990 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MT-CO3: --

Human Gene Mutation Database (HGMD): MT-CO3
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-CO3
DNA2.0 Custom Variant and Variant Library Synthesis for MT-CO3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 516050    OMIM disorders: --

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory
    chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease
    affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver
    dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and
    mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal
    death. A subset of patients manifest Leigh syndrome. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Recurrent myoglobinuria mitochondrial (RM-MT) [MIM:550500]: Recurrent myoglobinuria is characterized by
    recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain
    and weakness, and followed by excretion of myoglobin in the urine. Note=The gene represented in this entry may be
    involved in disease pathogenesis

  • 20/39 diseases for MT-CO3 (see all 39):    About MalaCards
    mitochondrial myopathy with lactic acidosis    melas syndrome    leber hereditary optic neuropathy    leigh-like syndrome
    mitochondrial dna-associated leigh syndrome and narp    lactic acidosis    metabolic acidosis    optic neuritis
    neuritis    renal tubular acidosis    encephalomyopathy    mitochondrial disorders
    myopathy    neuropathy    open-angle glaucoma    acne
    peripheral neuropathy    chagas disease    hypotonia    glaucoma

    1 disease from the University of Copenhagen DISEASES database for MT-CO3:
    Leber hereditary optic neuropathy

    MT-CO3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for MT-CO3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers hereditary optic neuropathy 58.5 1 8240356 (1)
    mitochondrial myopathies 54.1 2 12414820 (1), 15173241 (1)
    acidosis lactic 42.3 1 12414820 (1)
    hepatitis b 5.23 4 16677157 (3), 15334674 (1)
    tumors 0 1 12964965 (1)
    carcinoma 0 1 2154329 (1)

    GeneTests: MT-CO3
    GeneReviews: MT-CO3
    Genetic Association Database (GAD): MT-CO3

    Export disorders for MT-CO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT-CO3 gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with MT-CO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitochondrial DNA mutations with Leber's hereditary optic neuropathy in Japanese patients with open-angle glaucoma. (PubMed id 16604388)1, 4 Inagaki Y....Fukuchi T. (2006)
    2. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (1981)
    3. A MELAS syndrome family harboring two mutations in mitochondrial genome. (PubMed id 18587274)1, 9 Choi B.O....Chung K.W. (2008)
    4. Mutations in mtDNA-encoded cytochrome c oxidase subunit genes causing isolated myopathy or severe encephalomyopathy. (PubMed id 16288875)1, 9 Horvath R....Lochmuller H. (2005)
    5. Cytochrome c oxidase mutations in Leber hereditary optic neuropathy. (PubMed id 8240356)2, 9 Johns D.R. and Neufeld M.J. (1993)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Molecular-clinical correlation in a family with a nov el heteroplasmic Leigh syndrome missense mutation in the mitochondrial cytochro me c oxidase III gene. (PubMed id 20525945)1 Mkaouar-Rebai E....Fakhfakh F. (2011)
    10. Novel single base pair COX III subunit deletion of mi tochondrial DNA associated with rhabdomyolysis. (PubMed id 21163656)1 Marotta R....Collins S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4514 HGNC: 7422 Ensembl:ENSG00000198938 euGenes: HUgn4514 ECgene: MT-CO3 Kegg: 4514
    H-InvDB: MT-CO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT-CO3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MT-CO3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT-CO3 gene:
    Search GeneIP for patents involving MT-CO3

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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