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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT-CO3 Gene

protein-coding   GIFtS: 40
GCID: GCMTP009209

mitochondrially encoded cytochrome c oxidase III

(Previous name: cytochrome c oxidase III )
(Previous symbol: MTCO3)
 Explore 38 diseases affiliated with
MT-CO3 via our new
 Human Malady Compendium 
Biological research products
for MT-CO3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrially Encoded Cytochrome C Oxidase III1     CO31
COIII1 2 3     Cytochrome C Oxidase Subunit III2
MTCO31 2 3     COXIII3
COX31 2     Cytochrome C Oxidase Polypeptide III3
Cytochrome C Oxidase III1 2     EC 1.9.3.18

External Ids:    HGNC: 74221   Entrez Gene: 45142   Ensembl: ENSG000001989387   OMIM: 5160505   UniProtKB: P004143   

Export aliases for MT-CO3 gene to outside databases

Previous GC identifer: GC00U921585


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
Function: Subunits I, II and III form the functional core of the enzyme complex

Gene Wiki entry for MT-CO3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MT-CO3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MT-CO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-CO3


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP009209:  view genomic region     (about GC identifiers)

Start:
9,207 bp from pter      End:
9,990 bp from pter
Size:
784 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 3  
Size: 261 amino acids; 29951 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q14Y83

Explore the universe of human proteins at neXtProt for MT-CO3: NX_P00414

4/8 DME Specific Peptides for MT-CO3 (P00414) (see all 8)
 GFFWAFY  DVVWLFL  EVPLLNT  TGFHGLHV 

MT-CO3 Protein expression data from MOPED and PaxDb:    About this image 
MT-CO3 Protein Expression

ENSEMBL proteins: 
 ENSP00000354982  
Reactome Protein details: P00414
Human Recombinant Protein Products for MT-CO3: 
Browse Purified and Recombinant Proteins at EMD Millipore
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Uscn Proteins for MT-CO3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS--
GO:0016021integral to membrane IEA--

MT-CO3 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for MT-CO3


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MT-CO3 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR024791 Cyt_c/ubiquinol_Oxase_su3
 IPR013833 Cyt_c_oxidase_su3_a-hlx
 IPR000298 Cyt_c_oxidase_su3

Graphical View of Domain Structure for InterPro Entry P00414

ProtoNet protein and cluster: P00414

1 Blocks protein family: IPB000298 Cytochrome c oxidase

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
Similarity: Belongs to the cytochrome c oxidase subunit 3 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: COX3_HUMAN, P00414
Function: Subunits I, II and III form the functional core of the enzyme complex

     Enzyme Number (IUBMB): EC 1.9.3.12

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004129cytochrome-c oxidase activity NAS--
     
MT-CO3 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MT-CO3 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT-CO3
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MT-CO3
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Gene Editing
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Cell Line
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In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT-CO3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
Oxidative phosphorylation0.63
Respiratory electron transport0.81
Parkinson's disease0.61
Electron Transport Chain0.76
Alzheimer's disease0.43
The citric acid (TCA) cycle and respiratory electron transport0.72
Huntington's disease0.40
2Metabolism
Metabolism1.00
Metabolic pathways0.38
3Cardiac muscle contraction
Cardiac muscle contraction1.00

Pathway sources
See GeneCards unified pathways
Show all pathways


1 BioSystems Pathway for MT-CO3 
    Electron Transport Chain

4        Reactome Pathways for MT-CO3
    Respiratory electron transport
Metabolism
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport


5/6         Kegg Pathways  (Kegg details for MT-CO3) (see all 6):
    Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Alzheimer's disease
Parkinson's disease


MT-CO3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-CO3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for MT-CO3 (P004142, 3 ENSP000003549824) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
InteractantInteraction Details
GeneCardExternal ID(s)
ATP5BP065763, ENSP000002620304I2D: score=1 STRING: ENSP00000262030
MT-ATP6P008463, ENSP000003546324I2D: score=1 STRING: ENSP00000354632
MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
OXA1LQ150703, ENSP000002858484I2D: score=1 STRING: ENSP00000285848
ELANEP082463I2D: score=1 
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006123mitochondrial electron transport, cytochrome c to oxygen NAS--
GO:0019646aerobic electron transport chain IEA--
GO:0022904respiratory electron transport chain TAS--
GO:0044281small molecule metabolic process TAS--

MT-CO3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MT-CO3 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MT-CO3

2 DrugBank Compounds for MT-CO3    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Cholic Acid-- 81-25-4target--10592235
N-Formylmethionine-- --target--10592235

4 Novoseek chemical compound relationships for MT-CO3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nadh 58.1 8 18587274 (1), 16861209 (1), 12696067 (1), 1701727 (1) (see all 6)
citrate 40.1 2 16160866 (1)
atp 35.1 7 9623767 (2), 8392708 (1), 15639345 (1), 7533057 (1)
glucose 0 1 18000087 (1)

Search CenterWatch for drugs/clinical trials and news about MT-CO3 / COX3 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362079

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MT-CO3
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT-CO3
Sirion Biotech Custom design and validation of potent shRNA sequences against MT-CO3 
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer
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Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MT-CO3
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-CO3
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CO3

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MT-CO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
MT-CO3 Expression
About this image
See MT-CO3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT-CO3
    SABiosciences Custom PCR Arrays for MT-CO3

Primer
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Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CO3
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT-CO3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for MT-CO3 gene from 10/25 species (see all 25)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia mt-Co35
COX31
mitochondrially encoded cytochrome c oxidase III5
cytochrome c oxidase subunit III1
76.25(n)1
85.82(a)1
  MT5
177101  COX3_345386041  NP_904334.11 
 86075 
chicken
(Gallus gallus)
Aves COX31 cytochrome c oxidase subunit III 71.65(n)
73.18(a)
  807637  COX3_166240019  NP_006921.2 
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.81552 Transcribed sequence with moderate similarity to protein more 77.03(n)    CF152495.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.249112 Danio rerio cDNA clone MGC73301 IMAGE4787562, complete more 74.23(n)    BC060932.1 
fruit fly
(Drosophila melanogaster)
Insecta COX31 cytochrome c oxidase subunit III 64.61(n)
63.71(a)
  192471  COX3_5835239  NP_008282.1 
worm
(Caenorhabditis elegans)
Secernentea MTCE.236
Cytochrome c oxidase subunit 3
43(a)
1 ↔ 1
MtDNA(5678-6449)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX3(Q0275)4
COX31
Subunit III of cytochrome c oxidase, which is the terminal more4
Cox3p1
49.61(n)1
44.19(a)1
  17(79213-80022)4
8546271, 4  NP_009328.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons cox31 cytochrome c oxidase subunit 3 59.4(n)
57.59(a)
  814601  cox3_26556997  NP_085532.2 
rice
(Oryza sativa)
Liliopsida Os.247412 Transcribed sequence with weak similarity to protein more 73.63(n)    CA762510.1 
E. coli
(Escherichia coli)
Gamma proteobacteria cyoC6
cytochrome o ubiquinol oxidase subunit III
23(a)
1 ↔ 1
Chromosome(447270-447884) b0430


ENSEMBL Gene Tree for MT-CO3 (if available)
TreeFam Gene Tree for MT-CO3 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MT-CO3 gene
3 SIMAP similar genes for MT-CO3 using alignment to 1 protein entry:     COX3_HUMAN:
CO3    COIII    COX3

MT-CO3 for paralogs           About GeneDecksing


5/63 Pseudogenes.org Pseudogenes for MT-CO3 (see all 63)
PGOHUM00000238688 PGOHUM00000242446 PGOHUM00000242815 PGOHUM00000248440 PGOHUM00000247777


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Human Gene Mutation Database (HGMD): MT-CO3
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT-CO3
DNA2.0 Custom Variant and Variant Library Synthesis for MT-CO3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MT-CO3 for disorders           About GeneDecksing

OMIM gene information: 516050    OMIM disorders: --

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
  • Defects in MT-CO3 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally
  • inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac
    conduction defects and neurological defects have also been described in some patients. LHON results from primary
    mitochondrial DNA mutations affecting the respiratory chain complexes
  • Defects in MT-CO3 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as
  • cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical
    manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.
    Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness,
    excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients
    manifest Leigh syndrome
  • Defects in MT-CO3 are associated with recurrent myoglobinuria mitochondrial (RM-MT) [MIM:550500]. Recurrent
  • myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle)
    associated with muscle pain and weakness, and followed by excretion of myoglobin in the urine

    20/38 diseases for MT-CO3 (see all 38):    About MalaCards
    mitochondrial dna-associated leigh syndrome and narp    leber hereditary optic neuropathy    open-angle glaucoma    leigh-like syndrome
    mitochondrial myopathy with lactic acidosis    lactic acidosis    renal tubular acidosis    optic neuritis
    melas syndrome    neuritis    papillary thyroid carcinoma    peripheral neuropathy
    glaucoma    neuropathy    hepatitis b    myocardial infarction
    myopathy    encephalomyopathy    chagas disease    thyroid carcinoma

    2 diseases from the University of Copenhagen DISEASES database for MT-CO3:
    Metabolic acidosis     Leber hereditary optic neuropathy

    6 Novoseek disease relationships for MT-CO3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers hereditary optic neuropathy 58.5 1 8240356 (1)
    mitochondrial myopathies 54.1 2 12414820 (1), 15173241 (1)
    acidosis lactic 42.3 1 12414820 (1)
    hepatitis b 5.23 4 16677157 (3), 15334674 (1)
    tumors 0 1 12964965 (1)
    carcinoma 0 1 2154329 (1)

    GeneTests: MT-CO3
    Mitochondrial DNA-Associated Leigh Syndrome and NARP
    Leber Hereditary Optic Neuropathy


    Export disorders for MT-CO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT-CO3 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with MT-CO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (1981)
    2. A MELAS syndrome family harboring two mutations in mitochondrial genome. (PubMed id 18587274)1, 9 Choi B.O....Chung K.W. (2008)
    3. Mutations in mtDNA-encoded cytochrome c oxidase subunit genes causing isolated myopathy or severe encephalomyopathy. (PubMed id 16288875)1, 9 Horvath R....Lochmuller H. (2005)
    4. Cytochrome c oxidase mutations in Leber hereditary optic neuropathy. (PubMed id 8240356)2, 9 Johns D.R. and Neufeld M.J. (1993)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    6. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
    7. Molecular-clinical correlation in a family with a nov el heteroplasmic Leigh syndrome missense mutation in the mitochondrial cytochro me c oxidase III gene. (PubMed id 20525945)1 Mkaouar-Rebai E....Fakhfakh F. (2011)
    8. Novel single base pair COX III subunit deletion of mi tochondrial DNA associated with rhabdomyolysis. (PubMed id 21163656)1 Marotta R....Collins S.J. (2011)
    9. Major arc mitochondrial DNA deletions in cytochrome c oxidase-deficient human cochlear spiral ganglion cells. (PubMed id 20085441)1 Markaryan A....Hinojosa R. (2010)
    10. MtSNPscore: a combined evidence approach for assessin g cumulative impact of mitochondrial variations in disease. (PubMed id 19758471)1 Bhardwaj A....Tiwari S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4514 HGNC: 7422 Ensembl:ENSG00000198938 euGenes: HUgn4514 ECgene: MT-CO3 Kegg: 4514
    H-InvDB: MT-CO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MT-CO3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MT-CO3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MT-CO3 gene:
    Search GeneIP for patents involving MT-CO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
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    von Willebrand factor
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