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MT-CO3 Gene

protein-coding   GIFtS: 44
GCID: GCMTP009209

Mitochondrially Encoded Cytochrome C Oxidase III

(Previous name: cytochrome c oxidase III)
(Previous symbol: MTCO3)
  See MT-CO3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrially Encoded Cytochrome C Oxidase III1     Cytochrome C Oxidase Subunit III2
MTCO31 2 3     COXIII3
Cytochrome C Oxidase III1 2     Cytochrome C Oxidase Polypeptide III3
COIII2 3     EC 1.9.3.18
COX32     

External Ids:    HGNC: 74221   Entrez Gene: 45142   Ensembl: ENSG000001989387   OMIM: 5160505   UniProtKB: P004143   

Export aliases for MT-CO3 gene to outside databases

Previous GC identifer: GC00U921585


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-CO3 Gene:
MT-CO3 (mitochondrially encoded cytochrome c oxidase III) is a protein-coding gene. Diseases associated with MT-CO3 include myoglobinuria, acute recurrent, autosomal recessive, and leigh-like syndrome.

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
Function: Subunits I, II and III form the functional core of the enzyme complex

Gene Wiki entry for MT-CO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-CO3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-CO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-CO3


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP009209:       (about GC identifiers)

Start:
9,207 bp from pter      End:
9,990 bp from pter
Size:
784 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COX3_HUMAN, P00414 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 3  
Size: 261 amino acids; 29951 Da
Secondary accessions: Q14Y83

Explore the universe of human proteins at neXtProt for MT-CO3: NX_P00414

Explore proteomics data for MT-CO3 at MOPED

Selected DME Specific Peptides for MT-CO3 (P00414) (see all 8)
 GFFWAFY  DVVWLFL  EVPLLNT  TGFHGLHV 


See MT-CO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000354982  
Reactome Protein details: P00414

MT-CO3 Human Recombinant Protein Products:

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antibodies-online peptides for MT-CO3

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antibodies-online antibodies for MT-CO3 (30 products) 

MT-CO3 Assay Products:

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Search eBioscience for ELISAs for MT-CO3 
antibodies-online kits for MT-CO3 (19 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
comIV: Mitochondrial respiratory chain complex / Complex IV

3 InterPro protein domains:
 IPR024791 Cyt_c/ubiquinol_Oxase_su3
 IPR013833 Cyt_c_oxidase_su3_a-hlx
 IPR000298 Cyt_c_oxidase_su3

Graphical View of Domain Structure for InterPro Entry P00414

ProtoNet protein and cluster: P00414

1 Blocks protein domain: IPB000298 Cytochrome c oxidase

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
Similarity: Belongs to the cytochrome c oxidase subunit 3 family


Find genes that share domains with MT-CO3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: COX3_HUMAN, P00414
Function: Subunits I, II and III form the functional core of the enzyme complex

     Enzyme Number (IUBMB): EC 1.9.3.12

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004129cytochrome-c oxidase activity ----
GO:0015002heme-copper terminal oxidase activity ----
     
Find genes that share ontologies with MT-CO3           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for MT-CO3

miRNA
Products:
    
miRTarBase miRNAs that target MT-CO3:
hsa-mir-196a-5p (MIRT048192), hsa-mir-320c (MIRT036178), hsa-let-7c-5p (MIRT051745), hsa-let-7b-5p (MIRT051976), hsa-let-7e-5p (MIRT051535), hsa-mir-484 (MIRT042090), hsa-mir-26a-5p (MIRT050111), hsa-mir-296-3p (MIRT038405), hsa-mir-28-3p (MIRT038946), hsa-mir-196b-5p (MIRT042659), hsa-mir-320a (MIRT044848), hsa-mir-186-5p (MIRT045024), hsa-mir-744-5p (MIRT037543)

Block miRNA regulation of human, mouse, rat MT-CO3 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate MT-CO3
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat MT-CO3

Gene Editing
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CO3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
COX3_HUMAN, P00414: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
plasma membrane3
lysosome2
nucleus2
extracellular1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005743mitochondrial inner membrane ----
GO:0016020membrane ----
GO:0016021integral component of membrane ----
GO:0045277respiratory chain complex IV ----

Find genes that share ontologies with MT-CO3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MT-CO3 About    
See pathways by source

SuperPathContained pathways About
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
Oxidative phosphorylation0.64
Respiratory electron transport0.81
Parkinson's disease0.57
Electron Transport Chain0.75
Huntington's disease0.45
The citric acid (TCA) cycle and respiratory electron transport0.71
Non-alcoholic fatty liver disease (NAFLD)0.41
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3Alzheimer's disease
Alzheimer's disease0.44
4Cardiac muscle contraction
Cardiac muscle contraction


Find genes that share SuperPaths with MT-CO3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for MT-CO3
    Electron Transport Chain

1 Reactome Pathway for MT-CO3
    Respiratory electron transport


Selected Kegg Pathways  (Kegg details for MT-CO3) (see all 7):
    Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-CO3
Interactions:

    Search GeneGlobe Interaction Network for MT-CO3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MT-CO3 (P004141, 2, 3 ENSP000003549824) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
InteractantInteraction Details
GeneCardExternal ID(s)
ATP5BP065763, ENSP000002620304I2D: score=1 STRING: ENSP00000262030
MT-ATP6P008463, ENSP000003546324I2D: score=1 STRING: ENSP00000354632
MT-CO1P003953, ENSP000003544994I2D: score=1 STRING: ENSP00000354499
SNCAP378401, ENSP000003383454EBI-3932264,EBI-985879 STRING: ENSP00000338345
OXA1LQ150703, ENSP000002858484I2D: score=1 STRING: ENSP00000285848
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006123mitochondrial electron transport, cytochrome c to oxygen ----
GO:0008535respiratory chain complex IV assembly ----
GO:0019646aerobic electron transport chain ----
GO:0022904respiratory electron transport chain ----
GO:0044237cellular metabolic process ----

Find genes that share ontologies with MT-CO3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MT-CO3 (COX3)

2 DrugBank Compounds for MT-CO3    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Cholic Acid-- 81-25-4target--10592235
N-Formylmethionine-- --target--10592235

4 Novoseek inferred chemical compound relationships for MT-CO3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nadh 58.1 8 18587274 (1), 16861209 (1), 12696067 (1), 1701727 (1) (see all 6)
citrate 40.1 2 16160866 (1)
atp 35.1 7 9623767 (2), 8392708 (1), 15639345 (1), 7533057 (1)
glucose 0 1 18000087 (1)



Find genes that share compounds with MT-CO3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362079
miRNA
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Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat MT-CO3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MT-CO3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MT-CO3
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Primer
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Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MT-CO3
  QuantiTect SYBR Green Assays in human, mouse, rat MT-CO3
  QuantiFast Probe-based Assays in human, mouse, rat MT-CO3

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MT-CO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MT-CO3 Expression
About this image

MT-CO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MT-CO3 Protein Expression
    Custom PCR Arrays for MT-CO3
Primer
Products:
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CO3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CO3 gene from Selected species (see all 22)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia mt-Co35
COX31
mitochondrially encoded cytochrome c oxidase III5
COX31
76.25(n)1
85.82(a)1
  MT5
177101  COX3_345386041  NP_904334.11 
 86075 
chicken
(Gallus gallus)
Aves COX31 COX3 71.65(n)
73.18(a)
  807637  COX3_166240019  NP_006921.2 
lizard
(Anolis carolinensis)
Reptilia COX36
cytochrome c oxidase subunit III (mitochondrion)
78(a)
1 ↔ 1
MT(8535-9318)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.81552 Transcribed sequence with moderate similarity to protein more 77.03(n)    CF152495.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.249112 Danio rerio cDNA clone MGC73301 IMAGE4787562, complete more 74.23(n)    BC060932.1 
fruit fly
(Drosophila melanogaster)
Insecta COX31 COX3 64.61(n)
63.71(a)
  192471  COX3_5835239  NP_008282.1 
worm
(Caenorhabditis elegans)
Secernentea MTCE.236
Cytochrome c oxidase subunit 3
43(a)
1 ↔ 1
MtDNA(5678-6449) WBGene00010962
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX3(Q0275)4
COX31
Subunit III of cytochrome c oxidase, which is the terminal more4
COX31
49.61(n)1
44.19(a)1
  17(79213-80022)4
8546271, 4  NP_009328.11, 4 
thale cress
(Arabidopsis thaliana)
eudicotyledons cox31 cox3 59.04(n)
56.59(a)
  814601  cox3_26556997  NP_085532.2 
rice
(Oryza sativa)
Liliopsida Os.247412 Transcribed sequence with weak similarity to protein more 73.63(n)    CA762510.1 


ENSEMBL Gene Tree for MT-CO3 (if available)
TreeFam Gene Tree for MT-CO3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MT-CO3 gene
4 SIMAP similar genes for MT-CO3 using alignment to 1 protein entry:     COX3_HUMAN:
CO3    COIII    coxIII    COX3

Find genes that share paralogs with MT-CO3           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for MT-CO3 (see all 63)
PGOHUM00000238688 PGOHUM00000242446 PGOHUM00000242815 PGOHUM00000248440 PGOHUM00000247777


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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8 SNPs for MT-CO3    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr MT posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0021684
Leber hereditary optic neuropathy (LHON)4--see VAR_0021682 A T mis40--------
VAR_0021674
Leber hereditary optic neuropathy (LHON)4--see VAR_0021672 G S mis40--------
rs28538251,2,4
----see VAR_0085752 mis40--------
VAR_0085774
----see VAR_0085772 V I mis40--------
VAR_0021694
----see VAR_0021692 F L mis40--------
VAR_0085764
----see VAR_0085762 Q R mis40--------
VAR_0085744
----see VAR_0085742 F S mis40--------
VAR_0085734
----see VAR_0085732 H R mis40--------

HapMap Linkage Disequilibrium report for MT-CO3 (9207 - 9990 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MT-CO3: --
Human Gene Mutation Database (HGMD): MT-CO3
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-CO3
DNA2.0 Custom Variant and Variant Library Synthesis for MT-CO3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 516050    OMIM disorders: --

UniProtKB/Swiss-Prot: COX3_HUMAN, P00414
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute
    or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological
    defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations
    affecting the respiratory chain complexes. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory
    chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease
    affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver
    dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and
    mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal
    death. A subset of patients manifest Leigh syndrome. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Recurrent myoglobinuria mitochondrial (RM-MT) [MIM:550500]: Recurrent myoglobinuria is characterized by
    recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain
    and weakness, and followed by excretion of myoglobin in the urine. Note=The gene represented in this entry may be
    involved in disease pathogenesis

  • 11 diseases for MT-CO3:    
    About MalaCards
    myoglobinuria, acute recurrent, autosomal recessive    leigh-like syndrome    optic neuritis    leber hereditary optic neuropathy
    mitochondrial dna-associated leigh syndrome and narp    neuritis    cytochrome-c oxidase deficiency disease    melas syndrome
    leigh disease    mitochondrial disorders    papillary thyroid carcinoma

    1 disease from the University of Copenhagen DISEASES database for MT-CO3:
    Leber hereditary optic neuropathy

    Find genes that share disorders with MT-CO3           About GenesLikeMe

    6 Novoseek inferred disease relationships for MT-CO3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers hereditary optic neuropathy 58.5 1 8240356 (1)
    mitochondrial myopathies 54.1 2 12414820 (1), 15173241 (1)
    acidosis lactic 42.3 1 12414820 (1)
    hepatitis b 5.23 4 16677157 (3), 15334674 (1)
    tumors 0 1 12964965 (1)
    carcinoma 0 1 2154329 (1)

    GeneTests: MT-CO3
    GeneReviews: MT-CO3
    Genetic Association Database (GAD): MT-CO3

    Export disorders for MT-CO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT-CO3 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with MT-CO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitochondrial DNA mutations with Leber's hereditary optic neuropathy in Japanese patients with open-angle glaucoma. (PubMed id 16604388)1, 4 Inagaki Y....Fukuchi T. (Jpn. J. Ophthalmol. 2006)
    2. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (Nature 1981)
    3. A MELAS syndrome family harboring two mutations in mitochondrial genome. (PubMed id 18587274)1, 9 Choi B.O....Chung K.W. (amp 2008)
    4. Mutations in mtDNA-encoded cytochrome c oxidase subunit genes causing isolated myopathy or severe encephalomyopathy. (PubMed id 16288875)1, 9 HorvA!th R....LochmA1ller H. (Neuromuscul. Disord. 2005)
    5. Cytochrome c oxidase mutations in Leber hereditary optic neuropathy. (PubMed id 8240356)2, 9 Johns D.R. and Neufeld M.J. (Biochem. Biophys. Res. Commun. 1993)
    6. Mitochondrial DNA mutations and polymorphisms in asthenospermic infertile men. (PubMed id 23645088)1 Baklouti-Gargouri S....Ammar-Keskes L. (Mol. Biol. Rep. 2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (amp 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Molecular-clinical correlation in a family with a novel heteroplasmic Leigh syndrome missense mutation in the mitochondrial cytochrome c oxidase III gene. (PubMed id 20525945)1 Mkaouar-Rebai E....Fakhfakh F. (J. Child Neurol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4514 HGNC: 7422 Ensembl:ENSG00000198938 euGenes: HUgn4514 ECgene: MT-CO3 Kegg: 4514
    H-InvDB: MT-CO3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT-CO3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MT-CO3[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for MT-CO3 gene:
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