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Aliases for MT-CO2 Gene

Aliases for MT-CO2 Gene

  • Mitochondrially Encoded Cytochrome C Oxidase II 2 5
  • MTCO2 3 4
  • COII 3 4
  • Cytochrome C Oxidase Polypeptide II 4
  • Cytochrome C Oxidase Subunit II 3
  • Cytochrome C Oxidase II 2
  • EC 63
  • COXII 4
  • COX2 3

External Ids for MT-CO2 Gene

Previous HGNC Symbols for MT-CO2 Gene

  • MTCO2

Summaries for MT-CO2 Gene

GeneCards Summary for MT-CO2 Gene

MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include Mitochondrial Complex Iv Deficiency and Melas Syndrome. Among its related pathways are Gene Expression and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include oxidoreductase activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for MT-CO2 Gene

  • Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Gene Wiki entry for MT-CO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-CO2 Gene

Genomics for MT-CO2 Gene

Genomic Location for MT-CO2 Gene

7,586 bp from pter
8,269 bp from pter
684 bases
Plus strand

Genomic View for MT-CO2 Gene

Genes around MT-CO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-CO2 Gene

No data available for Regulatory Elements for MT-CO2 Gene

Proteins for MT-CO2 Gene

  • Protein details for MT-CO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q37526

    Protein attributes for MT-CO2 Gene

    227 amino acids
    Molecular mass:
    25565 Da
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MT-CO2 Gene

neXtProt entry for MT-CO2 Gene

Proteomics data for MT-CO2 Gene at MOPED

Selected DME Specific Peptides for MT-CO2 Gene

Post-translational modifications for MT-CO2 Gene

  • Ubiquitination at Lys 171
  • Modification sites at PhosphoSitePlus

Other Protein References for MT-CO2 Gene

ENSEMBL proteins:

Domains & Families for MT-CO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 2 family.
  • Belongs to the cytochrome c oxidase subunit 2 family.
genes like me logo Genes that share domains with MT-CO2: view

Function for MT-CO2 Gene

Molecular function for MT-CO2 Gene

UniProtKB/Swiss-Prot Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Enzyme Numbers (IUBMB) for MT-CO2 Gene

Phenotypes for MT-CO2 Gene

GenomeRNAi human phenotypes for MT-CO2:
genes like me logo Genes that share phenotypes with MT-CO2: view

Human Phenotype Ontology for MT-CO2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MT-CO2 Gene

Localization for MT-CO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-CO2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MT-CO2 Gene COMPARTMENTS Subcellular localization image for MT-CO2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
chloroplast 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0045277 respiratory chain complex IV IDA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MT-CO2: view

Pathways & Interactions for MT-CO2 Gene

genes like me logo Genes that share pathways with MT-CO2: view

Gene Ontology (GO) - Biological Process for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen NAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0009409 response to cold IEA --
GO:1902600 hydrogen ion transmembrane transport NAS --
genes like me logo Genes that share ontologies with MT-CO2: view

No data available for SIGNOR curated interactions for MT-CO2 Gene

Drugs & Compounds for MT-CO2 Gene

(10) Drugs for MT-CO2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0
SCIO-469 Investigational Pharma Target 0
Copper Pharma 161

(7) Additional Compounds for MT-CO2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with MT-CO2: view

Transcripts for MT-CO2 Gene

mRNA/cDNA for MT-CO2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-CO2 Gene

No ASD Table

Relevant External Links for MT-CO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-CO2 Gene

mRNA expression in normal human tissues for MT-CO2 Gene

Protein differential expression in normal tissues from HIPED for MT-CO2 Gene

This gene is overexpressed in Heart (9.1) and Nasal epithelium (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT-CO2 Gene

genes like me logo Genes that share expression patterns with MT-CO2: view

Protein tissue co-expression partners for MT-CO2 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MT-CO2 Gene

Orthologs for MT-CO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COX2 35
  • 71.21 (n)
  • 74.55 (a)
MT-CO2 36
  • 73 (a)
(Canis familiaris)
Mammalia COX2 35
  • 71.52 (n)
  • 75.45 (a)
COX2 36
  • 73 (a)
(Mus musculus)
Mammalia COX2 35
  • 72.58 (n)
  • 74.55 (a)
mt-Co2 16
mt-Co2 36
  • 71 (a)
(Pan troglodytes)
Mammalia COX2 35
  • 90.46 (n)
  • 96.92 (a)
MT-CO2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia COX2 35
  • 72.27 (n)
  • 74.09 (a)
(Monodelphis domestica)
Mammalia COII 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia MT-CO2 36
  • 70 (a)
(Gallus gallus)
Aves COX2 35
  • 69.41 (n)
  • 68.04 (a)
gga-mir-3527 36
  • 66 (a)
(Anolis carolinensis)
Reptilia COX2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia COX2 35
  • 68.94 (n)
  • 69.55 (a)
Str.8896 35
(Danio rerio)
Actinopterygii COX2 35
  • 68.48 (n)
  • 68.64 (a)
mt-co2 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta COX2 35
  • 59.67 (n)
  • 59.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta COX2 35
  • 57.69 (n)
  • 57.99 (a)
mt:CoII 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea COX2 35
  • 51.22 (n)
  • 50 (a)
MTCE.31 36
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AMI001W 35
  • 50.55 (n)
  • 45.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes COX2 35
  • 51.5 (n)
  • 46.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX2 35
  • 48.5 (n)
  • 44.55 (a)
COX2 36
  • 38 (a)
COX2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons cox2 35
  • 55.82 (n)
  • 51.89 (a)
(Oryza sativa)
Liliopsida cox2 35
  • 54.21 (n)
  • 49.07 (a)
Os.23374 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cox2 35
  • 50.39 (n)
  • 44.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for MT-CO2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MT-CO2 Gene

Gene Tree for MT-CO2 (if available)
Gene Tree for MT-CO2 (if available)

Paralogs for MT-CO2 Gene

(2) SIMAP similar genes for MT-CO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-CO2: view

No data available for Paralogs for MT-CO2 Gene

Variants for MT-CO2 Gene

Sequence variations from dbSNP and Humsavar for MT-CO2 Gene

SNP ID Clin Chr MT pos Sequence Context AA Info Type
VAR_008390 Colorectal cancer
VAR_008571 -
VAR_008572 -
VAR_008863 -
VAR_011344 -

Relevant External Links for MT-CO2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-CO2 Gene

Disorders for MT-CO2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MT-CO2 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex iv deficiency
  • cytochrome-c oxidase deficiency disease
melas syndrome
  • mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes
  • chigger flea
  • infection by baylisascaris
  • infection by anisakis larva
- elite association - COSMIC cancer census association via MalaCards


  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO:0000269 PubMed:10486321}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MT-CO2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MT-CO2: view

No data available for Genatlas for MT-CO2 Gene

Publications for MT-CO2 Gene

  1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PMID: 17619138) Ahari S.E. … Bahar M.A. (Cell. Mol. Neurobiol. 2007) 3 23 48 67
  2. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications. (PMID: 19771519) Tripathy M.K. … Mitra D. (Apoptosis 2010) 3 23
  3. Altered expression of 12S/MT-RNR1, MT-CO2/COX2, and MT-ATP6 mitochondrial genes in prostate cancer. (PMID: 18409190) Abril J. … Nunes V. (Prostate 2008) 3 23
  4. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  5. The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria. (PMID: 10194136) Kato M.V. (Leuk. Lymphoma 1999) 3 23

Products for MT-CO2 Gene

Sources for MT-CO2 Gene