MT-CO2 Gene
protein-coding GIFtS: 48
GCID: GCMTP007587
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|
mitochondrially encoded cytochrome c oxidase II(Previous name: cytochrome c oxidase II )
(Previous symbol: MTCO2)
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Aliases
for MT-CO2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrially Encoded Cytochrome C Oxidase II1 | | Cytochrome C Oxidase II1 | | MTCO21 2 3 | | Cytochrome C Oxidase Subunit II2 | | COX21 2 | | COXII3 | | COII2 3 | | Cytochrome C Oxidase Polypeptide II3 | | CO21 | | EC 1.9.3.18 |
Export aliases for MT-CO2 gene to outside databases |
Summaries
for MT-CO2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COX2_HUMAN, P00403Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen towater. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochromec via its binuclear copper A center to the bimetallic center of the catalytic subunit 1
Gene Wiki entry for MT-CO2
|
Genomic Views
for MT-CO2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MT-CO2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MT-CO2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-CO2 |
Genomic Location:
Chromosome:MT
Ensembl cytogenetic band: MT HGNC chromosome: mitochondriaGeneLoc information about chromosome MT GeneLoc Exon Structure GeneLoc location for GCMTP007587: view genomic region
(about GC identifiers)
Start:
|
7,586 bp from pter |
End:
|
8,269 bp from pter |
Size:
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684 bases |
Orientation:
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plus strand |
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Proteins
for MT-CO2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX2_HUMAN, P00403 (See
protein sequence)Recommended Name: Cytochrome c oxidase subunit 2 Size: 227 amino acids; 25565 Da
Cofactor: Copper A
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for MT-CO2:3VRJ (3D)
Secondary accessions: Q37526Explore the universe of human proteins at neXtProt for MT-CO2: NX_P00403
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P00403
4/8 DME Specific Peptides for MT-CO2 (P00403) (see all 8)
MT-CO2 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000354876 Reactome Protein details: P00403
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MT-CO2 for ontologies About GeneDecksing
MT-CO2 Antibody Products:
Assay Products for MT-CO2: |
Protein
Domains /
Families
for MT-CO2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MT-CO2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P00403ProtoNet protein and cluster: P00403 1 Blocks protein family: IPB002429 Cytochrome c oxidase subunit II signature
UniProtKB/Swiss-Prot: COX2_HUMAN, P00403Similarity: Belongs to the cytochrome c oxidase subunit 2 family |
Function
for MT-CO2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COX2_HUMAN, P00403Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen towater. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochromec via its binuclear copper A center to the bimetallic center of the catalytic subunit 1Enzyme Number (IUBMB): EC 1.9.3.12
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
MT-CO2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MT-CO2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | | | 3 | Endothelin | | | 4 | Regulation of Wnt-mediated beta catenin signaling and target gene transcription | | | 5 | Cardiac muscle contraction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for MT-CO2
4 
Reactome Pathways for MT-CO2
5/6 
Kegg Pathways (Kegg details for MT-CO2) (see all 6):
MT-CO2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT-CO2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/292 Interacting proteins for MT-CO2 (P004032, 3 ENSP000003548764) via UniProtKB, MINT, STRING, and/or I2D (see all 292)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
MT-CO2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MT-CO2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MT-CO2 for compounds About GeneDecksing
 Browse Tocris compounds for MT-CO2
3 HMDB Compounds for MT-CO2 About this table
2 DrugBank Compounds for MT-CO2 About this table
10/12 Novoseek chemical compound relationships for MT-CO2 gene (see all 12) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| didanosine |
52.1 |
6 |
16940060 (3) |
| nadh |
49.1 |
10 |
15125232 (1), 7693563 (1), 15639345 (1), 17619138 (1) (see all 7) |
| glyceraldehyde 3-phosphate |
32.7 |
1 |
9840186 (1) |
| rofecoxib |
26.6 |
1 |
15678404 (1) |
| atp |
23.5 |
8 |
11686499 (1), 12583793 (1), 15639345 (1), 17619138 (1) |
| zidovudine |
19.7 |
1 |
15865227 (1) |
| pge2 |
12.6 |
6 |
16086235 (1), 12850501 (1), 17121089 (1) |
| citrate |
0.248 |
3 |
15577406 (1), 17341128 (1) |
| oxygen |
0 |
3 |
11686499 (1), 12470298 (1) |
| prostaglandin |
0 |
1 |
16086235 (1) |
Search CenterWatch for drugs/clinical trials and news about MT-CO2 / COX2
|
Transcripts
for MT-CO2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000361739(uc011mfi.2)
GeneLoc Exon Structure
|
Expression
for MT-CO2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MT-CO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MT-CO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT-CO2
SABiosciences Custom PCR Arrays for MT-CO2
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MT-CO2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-CO2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CO2 |
Orthologs
for MT-CO2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MT-CO2 gene from 9/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
mt-Co25
COX21 |
mitochondrially encoded cytochrome c oxidase II5
cytochrome c oxidase subunit II1 |
72.58(n)1
74.55(a)1 |
|
MT5
177091 COX2_345386011 NP_904331.11
70135 |
chicken
(Gallus gallus) |
Aves |
COX21 |
cytochrome c oxidase subunit II |
69.41(n)
68.04(a) |
|
807635 COX2_5834847 NP_006918.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.88962 |
Transcribed sequence with weak similarity to protein more |
73.73(n) |
|
CF376235.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
COX21 |
cytochrome c oxidase subunit II |
68.48(n)
68.64(a) |
|
140540 COX2_8395615 NP_059334.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
COX21 |
cytochrome c oxidase subunit II |
57.69(n)
57.99(a) |
|
192470 COX2_5835236 NP_008279.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
COX21 |
cytochrome c oxidase subunit II |
47.98(n)
44.44(a) |
|
2565697 COX2_5834892 NP_006962.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
COX2(Q0250)4
COX21 |
Subunit II of cytochrome c oxidase, which is the terminal more4
Cox2p1 |
50.16(n)1
46.19(a)1 |
|
17(73758-74513)4
8546221, 4 NP_009326.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
cox21 |
cytochrome c oxidase subunit 2 |
55.5(n)
52.36(a) |
|
814573 cox2_13449304 NP_085487.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.233742 |
Transcribed sequence with weak similarity to protein more |
73.52(n) |
|
CA759366.1 |
ENSEMBL Gene Tree for MT-CO2 (if available)
TreeFam Gene Tree for MT-CO2 (if available) |
Paralogs
for MT-CO2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MT-CO2 gene
2 SIMAP similar genes for MT-CO2 using alignment to 2 protein entries: COX2_HUMAN (see all proteins):COX2 COII
MT-CO2 for paralogs About GeneDecksing
5/39 Pseudogenes.org Pseudogenes for MT-CO2 (see all 39)
PGOHUM00000238513 PGOHUM00000238519 PGOHUM00000242448 PGOHUM00000242645 PGOHUM00000239308
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Genomic Variants
for MT-CO2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): MT-CO2
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MT-CO2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MT-CO2 for disorders About GeneDecksing
OMIM gene information: 516040
OMIM disorders: --
UniProtKB/Swiss-Prot: COX2_HUMAN, P00403
Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known ascytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinicalmanifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness,excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patientsmanifest Leigh syndrome
20/64  diseases for MT-CO2 (see all 64): About MalaCardskearns-sayre syndrome b-cell non-hodgkin lymphoma rift valley fever non-hodgkin lymphoma
mitochondrial encephalomyopathy traumatic brain injury type 2 diabetes mellitus severe combined immunodeficiency
brain injury encephalomyopathy lactic acidosis chronic obstructive pulmonary disease
hodgkin's lymphoma combined immunodeficiency myoclonus epilepsy merrf syndrome
myoclonus diabetes mellitus spinocerebellar ataxia bronchial asthma
2 diseases from the University of Copenhagen DISEASES database for MT-CO2:Malaria Mitochondrial myopathy 6 Novoseek disease relationships for MT-CO2 gene About this table
Genetic Association Database (GAD): MT-CO2
Export disorders for MT-CO2 gene to outside databases
|
Publications
for MT-CO2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MT-CO2 gene, integrated from 9 sources (see all 210):
(articles sorted by number of sources associating them with MT-CO2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. (PubMed id 15316498)1, 4 Szczeklik W....Szczeklik A. (2004)
- Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 4 Goodman J.E.... Harris C.C. (2004)
- A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1, 4 Watanabe I....Koga T. (2003)
- Increased incidence of mitochondrial cytochrome c-oxidase gene mutations in patients with myelodysplastic syndromes. (PubMed id 11849212)1, 4 Reddy P.L....Raza A. (2002)
- Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA. (PubMed id 2550900)1, 2 Power M.D.... Reeves R. (1989)
- Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (1981)
- Mitochondrial COII sequences and modern human origins. (PubMed id 8277847)2, 9 Ruvolo M.... Lin J. (1993)
- Altered expression of 12S/MT-RNR1, MT-CO2/COX2, and MT-ATP6 mitochondrial genes in prostate cancer. (PubMed id 18409190)1, 9 Abril J....Nunes V. (2008)
- The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria. (PubMed id 10194136)1, 9 Kato M.V. (1999)
- Differential modulation of mitochondrial OXPHOS syste m during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit CO X-II and its possible implications. (PubMed id 19771519)1, 9 Tripathy M.K. and Mitra D. (2010)
|
External Searches for MT-CO2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MT-CO2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MT-CO2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MT-CO2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MT-CO2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MT-CO2 |
|
| | |
About This Section
| Patent Information for MT-CO2 gene:
Search GeneIP for patents involving MT-CO2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MT-CO2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT-CO2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MT-CO2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT-CO2 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MT-CO2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT-CO2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT-CO2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MT-CO2 |
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 | | | MT-CO2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for MT-CO2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MT-CO2 |
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