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Aliases for MT-CO2 Gene

Aliases for MT-CO2 Gene

  • Mitochondrially Encoded Cytochrome C Oxidase II 2
  • MTCO2 3 4
  • COII 3 4
  • Cytochrome C Oxidase Polypeptide II 4
  • Cytochrome C Oxidase Subunit II 3
  • Cytochrome C Oxidase II 2
  • EC 1.9.3.1 63
  • COXII 4
  • COX2 3

External Ids for MT-CO2 Gene

Previous HGNC Symbols for MT-CO2 Gene

  • MTCO2

Summaries for MT-CO2 Gene

GeneCards Summary for MT-CO2 Gene

MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include tungiasis and baylisascariasis. Among its related pathways are Metabolism and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include oxidoreductase activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for MT-CO2 Gene

  • Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Gene Wiki entry for MT-CO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-CO2 Gene

Genomics for MT-CO2 Gene

Genomic Location for MT-CO2 Gene

Chromosome:
MT
Start:
7,586 bp from pter
End:
8,269 bp from pter
Size:
684 bases
Orientation:
Plus strand

Genomic View for MT-CO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-CO2 Gene

No data available for Regulatory Elements for MT-CO2 Gene

Proteins for MT-CO2 Gene

  • Protein details for MT-CO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00403-COX2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 2
    Protein Accession:
    P00403
    Secondary Accessions:
    • Q37526

    Protein attributes for MT-CO2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25565 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds a copper A center.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MT-CO2 Gene

neXtProt entry for MT-CO2 Gene

Proteomics data for MT-CO2 Gene at MOPED

Selected DME Specific Peptides for MT-CO2 Gene

Post-translational modifications for MT-CO2 Gene

  • Ubiquitination at Lys 171
  • Modification sites at PhosphoSitePlus

Other Protein References for MT-CO2 Gene

ENSEMBL proteins:

Domains & Families for MT-CO2 Gene

Graphical View of Domain Structure for InterPro Entry

P00403

UniProtKB/Swiss-Prot:

COX2_HUMAN :
  • Belongs to the cytochrome c oxidase subunit 2 family.
Family:
  • Belongs to the cytochrome c oxidase subunit 2 family.
genes like me logo Genes that share domains with MT-CO2: view

Function for MT-CO2 Gene

Molecular function for MT-CO2 Gene

UniProtKB/Swiss-Prot Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Enzyme Numbers (IUBMB) for MT-CO2 Gene

Gene Ontology (GO) - Molecular Function for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity --
GO:0005507 copper ion binding --
GO:0005515 protein binding --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with MT-CO2: view

Phenotypes for MT-CO2 Gene

GenomeRNAi human phenotypes for MT-CO2:
genes like me logo Genes that share phenotypes with MT-CO2: view

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MT-CO2 Gene

Localization for MT-CO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-CO2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-CO2 Gene COMPARTMENTS Subcellular localization image for MT-CO2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
chloroplast 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0045277 respiratory chain complex IV --
genes like me logo Genes that share ontologies with MT-CO2: view

Pathways & Interactions for MT-CO2 Gene

genes like me logo Genes that share pathways with MT-CO2: view

Gene Ontology (GO) - Biological Process for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen --
GO:0006367 transcription initiation from RNA polymerase II promoter --
GO:0007595 lactation --
GO:0009409 response to cold --
GO:0010467 gene expression --
genes like me logo Genes that share ontologies with MT-CO2: view

No data available for SIGNOR curated interactions for MT-CO2 Gene

Drugs & Compounds for MT-CO2 Gene

(10) Drugs for MT-CO2 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Didanosine Approved Pharma 150
Zidovudine Approved Pharma 489
N-Formylmethionine Experimental Pharma Target 0
SCIO-469 Investigational Pharma Target 0

(7) Additional Compounds for MT-CO2 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
glyceraldehyde 3-phosphate
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
lactate
genes like me logo Genes that share compounds with MT-CO2: view

Transcripts for MT-CO2 Gene

mRNA/cDNA for MT-CO2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-CO2 Gene

No ASD Table

Relevant External Links for MT-CO2 Gene

GeneLoc Exon Structure for
MT-CO2
ECgene alternative splicing isoforms for
MT-CO2

Expression for MT-CO2 Gene

mRNA expression in normal human tissues for MT-CO2 Gene

Protein differential expression in normal tissues from HIPED for MT-CO2 Gene

This gene is overexpressed in Heart (9.1) and Nasal epithelium (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT-CO2 Gene



genes like me logo Genes that share expression patterns with MT-CO2: view

Protein tissue co-expression partners for MT-CO2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MT-CO2 Gene

Orthologs for MT-CO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COX2 35
  • 71.21 (n)
  • 74.55 (a)
MT-CO2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX2 35
  • 71.52 (n)
  • 75.45 (a)
COX2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia COX2 35
  • 72.58 (n)
  • 74.55 (a)
mt-Co2 16
mt-Co2 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COX2 35
  • 90.46 (n)
  • 96.92 (a)
MT-CO2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia COX2 35
  • 72.27 (n)
  • 74.09 (a)
oppossum
(Monodelphis domestica)
Mammalia COII 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MT-CO2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX2 35
  • 69.41 (n)
  • 68.04 (a)
gga-mir-3527 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia COX2 35
  • 68.94 (n)
  • 69.55 (a)
Str.8896 35
zebrafish
(Danio rerio)
Actinopterygii COX2 35
  • 68.48 (n)
  • 68.64 (a)
mt-co2 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta COX2 35
  • 59.67 (n)
  • 59.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta COX2 35
  • 57.69 (n)
  • 57.99 (a)
mt:CoII 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea COX2 35
  • 51.22 (n)
  • 50 (a)
MTCE.31 36
  • 39 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AMI001W 35
  • 50.55 (n)
  • 45.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes COX2 35
  • 51.5 (n)
  • 46.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX2 35
  • 48.5 (n)
  • 44.55 (a)
COX2 36
  • 38 (a)
OneToOne
COX2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons cox2 35
  • 55.82 (n)
  • 51.89 (a)
rice
(Oryza sativa)
Liliopsida cox2 35
  • 54.21 (n)
  • 49.07 (a)
Os.23374 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cox2 35
  • 50.39 (n)
  • 44.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for MT-CO2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MT-CO2 Gene

ENSEMBL:
Gene Tree for MT-CO2 (if available)
TreeFam:
Gene Tree for MT-CO2 (if available)

Paralogs for MT-CO2 Gene

(2) SIMAP similar genes for MT-CO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-CO2: view

No data available for Paralogs for MT-CO2 Gene

Variants for MT-CO2 Gene

Sequence variations from dbSNP and Humsavar for MT-CO2 Gene

SNP ID Clin Chr MT pos Sequence Context AA Info Type MAF
VAR_008390 Colorectal cancer
VAR_008571 -
VAR_008572 -
VAR_008863 -
VAR_011344 -

Relevant External Links for MT-CO2 Gene

HapMap Linkage Disequilibrium report
MT-CO2
Human Gene Mutation Database (HGMD)
MT-CO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-CO2 Gene

Disorders for MT-CO2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MT-CO2 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
tungiasis
  • chigger flea
baylisascariasis
  • infection by baylisascaris
anisakiasis
  • infection by anisakis larva [ambiguous]
pyosalpinx
  • pyosalpingitis
isolated cytochrome c oxidase deficiency
  • isolated cox deficiency
- elite association

UniProtKB/Swiss-Prot

COX2_HUMAN
  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO:0000269 PubMed:10486321}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MT-CO2

Genetic Association Database (GAD)
MT-CO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT-CO2
genes like me logo Genes that share disorders with MT-CO2: view

No data available for Genatlas for MT-CO2 Gene

Publications for MT-CO2 Gene

  1. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications. (PMID: 19771519) Tripathy M.K. … Mitra D. (Apoptosis 2010) 23 67
  2. Probing population dynamics of Trypanosoma cruzi during progression of the chronic phase in chagasic patients. (PMID: 19357212) D'Avila D.A. … GalvALo L.M. (J. Clin. Microbiol. 2009) 23 67
  3. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. (PMID: 19393301) Sharma S. … Gomez-Pinilla F. (Neuroscience 2009) 23 67
  4. Extra-mitochondrial localization and likely reproductive function of a female-transmitted cytochrome c oxidase subunit II protein. (PMID: 19469787) Chakrabarti R. … Hoeh W. (Dev. Growth Differ. 2009) 23 67
  5. Mitochondrial compartment: a possible target of cadmium effects on breast epithelial cells. (PMID: 19266167) Cannino G. … Rinaldi A.M. (Mol. Cell. Biochem. 2009) 23 67

Products for MT-CO2 Gene

Sources for MT-CO2 Gene

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