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MT-CO2 Gene

protein-coding   GIFtS: 50
GCID: GCMTP007587

Mitochondrially Encoded Cytochrome C Oxidase II

(Previous name: cytochrome c oxidase II)
(Previous symbol: MTCO2)
  See MT-CO2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrially Encoded Cytochrome C Oxidase II1     Cytochrome C Oxidase Subunit II2
MTCO21 2 3     COXII3
COII2 3     Cytochrome C Oxidase Polypeptide II3
Cytochrome C Oxidase II1     EC 1.9.3.18
COX22     

External Ids:    HGNC: 74211   Entrez Gene: 45132   Ensembl: ENSG000001987127   OMIM: 5160405   UniProtKB: P004033   

Export aliases for MT-CO2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MT-CO2 Gene:
MT-CO2 (mitochondrially encoded cytochrome c oxidase II) is a protein-coding gene. Diseases associated with MT-CO2 include osteoblastoma, and cerebral aneurysms.

UniProtKB/Swiss-Prot: COX2_HUMAN, P00403
Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to
water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from
cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Gene Wiki entry for MT-CO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MT-CO2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MT-CO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MT-CO2


Genomic Location:
Chromosome:MT   

Ensembl cytogenetic band:  MT   HGNC chromosome: mitochondria

GeneLoc information about chromosome MT         GeneLoc Exon Structure

GeneLoc location for GCMTP007587:       (about GC identifiers)

Start:
7,586 bp from pter      End:
8,269 bp from pter
Size:
684 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COX2_HUMAN, P00403 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 2  
Size: 227 amino acids; 25565 Da
Cofactor: Copper A
1 PDB 3D structure from and Proteopedia for MT-CO2:
3VRJ (3D)    
Secondary accessions: Q37526

Explore the universe of human proteins at neXtProt for MT-CO2: NX_P00403

Explore proteomics data for MT-CO2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys171
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MT-CO2 (P00403) (see all 8)
     IALPSLR  IGHQWYW  FHDHALM  NHSFMPI 


    See MT-CO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000354876  
    Reactome Protein details: P00403

    MT-CO2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online antibodies for MT-CO2 (46 products) 

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    antibodies-online kits for MT-CO2 (32 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    5 InterPro protein domains:
     IPR002429 Cyt_c_oxidase_su2_C
     IPR014222 Cyt_c_oxidase_su2
     IPR011759 Cyt_c_oxidase_su2_TM_dom
     IPR008972 Cupredoxin
     IPR001505 Copper_CuA

    Graphical View of Domain Structure for InterPro Entry P00403

    ProtoNet protein and cluster: P00403

    1 Blocks protein domain: IPB002429 Cytochrome c oxidase subunit II signature

    UniProtKB/Swiss-Prot: COX2_HUMAN, P00403
    Similarity: Belongs to the cytochrome c oxidase subunit 2 family


    Find genes that share domains with MT-CO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX2_HUMAN, P00403
    Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to
    water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from
    cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

         Enzyme Number (IUBMB): EC 1.9.3.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity ----
    GO:0005507copper ion binding ----
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with MT-CO2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MT-CO2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MT-CO2:
    hsa-mir-17-5p (MIRT050864), hsa-mir-320a (MIRT044807), hsa-mir-99a-5p (MIRT048680), hsa-mir-652-3p (MIRT039467), hsa-mir-143-3p (MIRT003964), hsa-let-7a-5p (MIRT052383), hsa-mir-296-3p (MIRT038368), hsa-let-7b-5p (MIRT052290), hsa-mir-744-5p (MIRT037539), hsa-mir-1908-5p (MIRT035810), hsa-mir-100-5p (MIRT048596), hsa-mir-3934-5p (MIRT052894), hsa-let-7c-5p (MIRT051845), hsa-mir-101-3p (MIRT003965)

    Block miRNA regulation of human, mouse, rat MT-CO2 using miScript Target Protectors
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CO2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COX2_HUMAN, P00403: Mitochondrion inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0045277respiratory chain complex IV ----

    Find genes that share ontologies with MT-CO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MT-CO2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    5Endothelin
    Endothelin


    Find genes that share SuperPaths with MT-CO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for MT-CO2
        Electron Transport Chain
    Endothelin
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    1 Reactome Pathway for MT-CO2
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for MT-CO2) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MT-CO2
    Interactions:

        Search GeneGlobe Interaction Network for MT-CO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MT-CO2 (P004032, 3 ENSP000003548764) via UniProtKB, MINT, STRING, and/or I2D (see all 358)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5BP065762, 3, ENSP000002620304MINT-8079030 I2D: score=1 STRING: ENSP00000262030
    COX4I1P130732, 3, ENSP000002534524MINT-8079030 I2D: score=1 STRING: ENSP00000253452
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PHBP352322, 3, ENSP000003004084MINT-8079030 I2D: score=1 STRING: ENSP00000300408
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006123mitochondrial electron transport, cytochrome c to oxygen ----
    GO:0022900electron transport chain ----
    GO:0022904respiratory electron transport chain ----
    GO:0044237cellular metabolic process ----
    GO:0044281small molecule metabolic process ----

    Find genes that share ontologies with MT-CO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MT-CO2 (COX2)

    3 HMDB Compounds for MT-CO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for MT-CO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MT-CO2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    didanosine 52.1 6 16940060 (3)
    nadh 49.1 10 15125232 (1), 7693563 (1), 15639345 (1), 17619138 (1) (see all 7)
    glyceraldehyde 3-phosphate 32.7 1 9840186 (1)
    rofecoxib 26.6 1 15678404 (1)
    atp 23.5 8 11686499 (1), 12583793 (1), 15639345 (1), 17619138 (1)
    zidovudine 19.7 1 15865227 (1)
    pge2 12.6 6 16086235 (1), 12850501 (1), 17121089 (1)
    citrate 0.248 3 15577406 (1), 17341128 (1)
    oxygen 0 3 11686499 (1), 12470298 (1)
    prostaglandin 0 1 16086235 (1)



    Find genes that share compounds with MT-CO2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361739(uc011mfi.2)
    miRNA
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    Primer
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MT-CO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MT-CO2 Expression
    About this image

    MT-CO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MT-CO2 Protein Expression
        Custom PCR Arrays for MT-CO2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MT-CO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MT-CO2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia mt-Co25
    COX21
    mitochondrially encoded cytochrome c oxidase II5
    COX21
    72.58(n)1
    74.55(a)1
      MT5
    177091  COX2_345386011  NP_904331.11 
     70135 
    chicken
    (Gallus gallus)
    Aves COX21 COX2 69.41(n)
    68.04(a)
      807635  COX2_5834847  NP_006918.1 
    lizard
    (Anolis carolinensis)
    Reptilia COX26
    cytochrome c oxidase subunit II (mitochondrion)
    68(a)
    1 ↔ 1
    MT(6940-7627)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.88962 Transcribed sequence with weak similarity to protein more 73.73(n)    CF376235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii COX21 COX2 68.48(n)
    68.64(a)
      140540  COX2_8395615  NP_059334.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta COX21 COX2 57.69(n)
    57.99(a)
      192470  COX2_5835236  NP_008279.1 
    worm
    (Caenorhabditis elegans)
    Secernentea COX21 COX2 51.22(n)
    50(a)
      2565697  COX2_5834892  NP_006962.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COX2(Q0250)4
    COX21
    Subunit II of cytochrome c oxidase, which is the terminal more4
    COX21
    48.5(n)1
    44.55(a)1
      17(73758-74513)4
    8546221, 4  NP_009326.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons cox21 cox2 55.82(n)
    51.89(a)
      814573  cox2_13449304  NP_085487.1 
    rice
    (Oryza sativa)
    Liliopsida Os.233742 Transcribed sequence with weak similarity to protein more 73.52(n)    CA759366.1 


    ENSEMBL Gene Tree for MT-CO2 (if available)
    TreeFam Gene Tree for MT-CO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MT-CO2 gene
    2 SIMAP similar genes for MT-CO2 using alignment to 1 protein entry:     COX2_HUMAN:
    COII    COX2

    Find genes that share paralogs with MT-CO2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for MT-CO2 (see all 39)
    PGOHUM00000238513 PGOHUM00000238519 PGOHUM00000242448 PGOHUM00000242645 PGOHUM00000239308


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for MT-CO2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr MT posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0350854
    Mitochondrial complex IV deficiency (MT-C4D)4--see VAR_0350852 M K mis40--------
    VAR_0083904
    Colorectal cancer4--see VAR_0083902 V M mis40--------
    VAR_0113444
    ----see VAR_0113442 I V mis40--------
    VAR_0088634
    ----see VAR_0088632 D A mis40--------
    VAR_0085724
    ----see VAR_0085722 T M mis40--------
    VAR_0113454
    ----see VAR_0113452 A T mis40--------
    VAR_0085714
    ----see VAR_0085712 L P mis40--------

    HapMap Linkage Disequilibrium report for MT-CO2 (7586 - 8269 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MT-CO2: --
    Human Gene Mutation Database (HGMD): MT-CO2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MT-CO2
    DNA2.0 Custom Variant and Variant Library Synthesis for MT-CO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 516040    OMIM disorders: --

    UniProtKB/Swiss-Prot: COX2_HUMAN, P00403
  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory
    chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease
    affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver
    dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and
    mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal
    death. A subset of patients manifest Leigh syndrome. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 10 diseases for MT-CO2:    
    About MalaCards
    osteoblastoma    cerebral aneurysms    melas syndrome    tongue cancer
    phaeochromocytoma    kearns-sayre syndrome    cytochrome-c oxidase deficiency disease    merrf syndrome
    leigh disease    mitochondrial disorders

    3 diseases from the University of Copenhagen DISEASES database for MT-CO2:
    Malaria     Mitochondrial myopathy     Chagas disease

    Find genes that share disorders with MT-CO2           About GenesLikeMe

    6 Novoseek inferred disease relationships for MT-CO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mitochondrial encephalomyopathies 40.3 1 10205264 (1)
    carcinoma squamous cell 0 2 10422566 (1), 15814624 (1)
    osteosarcoma 0 1 10194136 (1)
    tumors 0 3 18409190 (2), 16775426 (1)
    carcinoma 0 2 1334139 (2)
    cancer 0 1 16728594 (1)

    Genetic Association Database (GAD): MT-CO2

    Export disorders for MT-CO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MT-CO2 gene, integrated from 10 sources (see all 216):
    (articles sorted by number of sources associating them with MT-CO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PubMed id 17619138)1, 4, 9 Ahari S.E....Bahar M.A. (Cell. Mol. Neurobiol. 2007)
    2. Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. (PubMed id 15316498)1, 4 Szczeklik W....Szczeklik A. (J. Allergy Clin. Immunol. 2004)
    3. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 4 Goodman J.E.... Harris C.C. (Carcinogenesis 2004)
    4. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1, 4 Watanabe I....Koga T. (Clin. Pharmacol. Ther. 2003)
    5. Increased incidence of mitochondrial cytochrome c-oxidase gene mutations in patients with myelodysplastic syndromes. (PubMed id 11849212)1, 4 Reddy P.L....Raza A. (Br. J. Haematol. 2002)
    6. Sequence and organization of the human mitochondrial genome. (PubMed id 7219534)1, 2 Anderson S.... Young I.G. (Nature 1981)
    7. Mitochondrial COII sequences and modern human origins. (PubMed id 8277847)2, 9 Ruvolo M.... Lin J. (Mol. Biol. Evol. 1993)
    8. Altered expression of 12S/MT-RNR1, MT-CO2/COX2, and MT-ATP6 mitochondrial genes in prostate cancer. (PubMed id 18409190)1, 9 Abril J....Nunes V. (Prostate 2008)
    9. The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria. (PubMed id 10194136)1, 9 Kato M.V. (amp 1999)
    10. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications. (PubMed id 19771519)1, 9 Tripathy M.K. and Mitra D. (Apoptosis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4513 HGNC: 7421 Ensembl:ENSG00000198712 euGenes: HUgn4513 ECgene: MT-CO2 Kegg: 4513
    H-InvDB: MT-CO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MT-CO2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MT-CO2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MT-CO2 gene:
    Search GeneIP for patents involving MT-CO2

    GeneCards and IP:
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